<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8S6</accession>
    <name>A0A3Q8I8S6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LdCL_100011300</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8S6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0780"/>
    <dbReference type="OrthoDB" id="265814at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU76667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="641" mass="68905" checksum="61D66CBC8C7BF384" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8U8</accession>
    <name>A0A3Q8I8U8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140015300</name>
        <name evidence="3" type="ORF">LDHU3_14.1220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8U8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1220"/>
    <dbReference type="OrthoDB" id="272975at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8411" checksum="85FAB567AF6C799C" modified="2019-04-10" version="1">MPAVPPPLSWKARLHNFYASNKRDVFFGFVAFFALATVARAEMMRKGVLERPPPQEVHPKVSREFGKSKHKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I926</accession>
    <accession>E9BAN7</accession>
    <name>A0A3Q8I926_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cytochrome b5-like Heme/Steroid binding domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Cytochrome_b5_putative/GeneDB:LmjF.11.0580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_30850</name>
        <name evidence="11" type="ORF">CGC21_0950</name>
        <name evidence="9" type="ORF">LDBPK_110490</name>
        <name evidence="7" type="ORF">LdCL_110011300</name>
        <name evidence="8" type="ORF">LDHU3_11.0780</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859026.1">
        <property type="nucleotide sequence ID" value="XM_003858978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I926"/>
    <dbReference type="GeneID" id="13389522"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0780"/>
    <dbReference type="OMA" id="APKWSET"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF145">
        <property type="entry name" value="B5, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP39841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="142" mass="15884" checksum="B497B6D3531D9054" modified="2019-04-10" version="1">MSEGELRVYSWEEIAKHTNDDDCWVVMYDKVLDVSKWLQEHPGGLDPIKDMAGMDITNSFESIGHSSTALVKSKSFIIGCVDPEESKMRKEAAKKASAPAPKWSETKREELRRYKGGEGIIPLPVLIGAMVAILALLFYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I960</accession>
    <name>A0A3Q8I960_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_110019000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1620"/>
    <dbReference type="OrthoDB" id="272952at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="444" mass="46808" checksum="198E9B97F954EACD" modified="2019-04-10" version="1">MAPKARSVAPKAQAGASPPEAREPLIIAAAFLDSVVAVSGVPVMMAQAAYVSFPSGAHLVAYQLCFLVPQLITTLVAEQLTMHVSASALLLFTLMCSTGSAAIVALSLSQRALSLFFASHILNGVFRHTKTLFGVTAKTLHMPTTDVSAAARYGMMAGMLLSGIAGDIMRDAVQVAQLFIGVEAAAATLVLAHLLLRSRTVVVTARVSQEYAQWLPSLARAPAVVYRSVSALIAVMLAASVNQVVYPIAAPAYGLPYSFAGAHLCFGMVLQMVLMPSVVDVAKRMARQWKSNVLLTGSAEDKLSVIAGLLLLAGCTVVPCASDFGPFVFYPASLLLVDLPAGVLSTLAASAVQETFGHGSGDAPKVARLLAHITQLVKMFAAPLRICTTESLRGYKYPVRYISIPLMTYALMYARTHNVTYAVTGLATTLLLLTSTVSSFEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9D0</accession>
    <name>A0A3Q8I9D0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_120018200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9D0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1160"/>
    <dbReference type="OrthoDB" id="1877432at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF642">
        <property type="entry name" value="INACTIVE LEUCINE-RICH REPEAT RECEPTOR KINASE XIAO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018694183" evidence="10">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30720" checksum="9D9DBCAE6FB51E50" modified="2019-04-10" version="1">MALCVRRLVLAATLAAVVALLPCTSSAPVARATETGDFTAAQRTNTLAVLQAFARAIPELGRKWTGDDFCSWEYTECNRTGVFVSVIGAPYAGTLPEMPVDVDYKHVIIRGLDFQQIKRLVGTLPASWSRLELLTLVSFPGCGVSGTLPASWRSMKSLALLWLEDGDSITGTVPPEWSSMRRLAMLLLRRLPLRSTLPIQWSSMASLKVLSLEGTQVYGSLPPEWSGMSKAQSLQLENCDLSGSLPPRVGCDAEAAYGLTEGQPLLRVCAGLVGPEGRSRCGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA35</accession>
    <name>A0A3Q8IA35_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Raptor N-terminal CASPase like domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200017300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1590"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001965">
        <property type="entry name" value="Raptor_N-terminal_CASPase_like_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="271"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1444"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1611"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1760"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1947"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2176"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1450"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1781"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2182"/>
            <end position="2195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2757" mass="294079" checksum="6D2D723BF756361F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAZ9</accession>
    <accession>E9BJL8</accession>
    <name>A0A3Q8IAZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Haloacid dehalogenase-like hydrolase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Haloacid_dehalogenase-like_hydrolase-like_protein /GeneDB:LmjF.28.1360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_281470</name>
        <name evidence="6" type="ORF">LdCL_280019400</name>
        <name evidence="7" type="ORF">LDHU3_28.1850</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862246.1">
        <property type="nucleotide sequence ID" value="XM_003862198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAZ9"/>
    <dbReference type="SMR" id="A0A3Q8IAZ9"/>
    <dbReference type="GeneID" id="13386982"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1850"/>
    <dbReference type="OMA" id="MPHLTYK"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF5">
        <property type="entry name" value="DEHALOGENASE-LIKE HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31898" checksum="B5720518AB901A77" modified="2019-04-10" version="1">MMSPKIKAVFVDMDGTLFDSGHFISPRTAKVIHALEERGVAFVVATGRPFPDVFGNLAKAGLRPDFIITSNGARVHDAQHNIVFACDMDAESVCRLFQLSPHLREDGVVDPAVEARRILFNVNCGDRWLTNECIPEVRAAFHPSFIYERVDPMVHTAKTLKGTHSMWIRGAHADLVCVQKYVDRELSHEIGCTFALPHILDCFRKGVDKGAAMEKVCKHLRIDLRETIAFGDGMNDIRMLTAAGQGFVMANAAEMVKQAAPELPVIQSNNEEGVARKLEELLAADAFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB03</accession>
    <name>A0A3Q8IB03_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclosporin 16, putative</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Cyclosporin_16_putative/GeneDB:LmjF.18.0880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_180014000</name>
        <name evidence="6" type="ORF">LDHU3_18.1130</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB03"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1130"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000073">
        <property type="entry name" value="Putative cyclosporin 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="865"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="784"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1022" mass="108278" checksum="264487389C0A6CFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBC3</accession>
    <name>A0A3Q8IBC3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol uptake protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_190018500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBC3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1590"/>
    <dbReference type="OrthoDB" id="261651at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="605" mass="69516" checksum="E5E1F451C38541D8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBR8</accession>
    <accession>E9BGB8</accession>
    <name>A0A3Q8IBR8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SET domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_17210</name>
        <name evidence="3" type="ORF">LDBPK_230990</name>
        <name evidence="2" type="ORF">LdCL_230016500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860999.1">
        <property type="nucleotide sequence ID" value="XM_003860951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBR8"/>
    <dbReference type="GeneID" id="13390197"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1340"/>
    <dbReference type="OMA" id="NYFFTCH"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="315"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="455" mass="48727" checksum="1841DEE4CB3A9F4B" modified="2019-04-10" version="1">MDPAAKAASELNTIFGRLGVLCEVCVTSAEGKHVKATASLEEGFALFEELPIVSWPSPSLLALSTPFCFQCLSLSSHQQSASETDAESPSPASSAALPKSWSQCTHCASYFCSPECQQASSRVHRLLCSCLPVVRESHVGRDGSGDAEDVKLTATQSLSSAPSSLASSTTSSEITLEALARCVAWITHRLSYVIEQQQLAHEVLQADYVFQQKQQAGDSARGATWSTASLIYQLFTQVVAPFSRLISPPDNVEFDGASLASWMAKLRLLLAEQCATQLLVASGAPLSDVRRHTLVFDEHQQQQAVPAPTLLWAEALVQVIFSTDTLRTLVGQMVLNAHAINDYVLPPGEALSTGVFDWVLKGAGLYSLLSCFNHSCVPNAAVSTVDGTHEIVLKTTRPIRAGEPLTITYIPLTAGAASRAERQRRLRNYFFTCHCPRCDAEAAASAALTGGGNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC11</accession>
    <name>A0A3Q8IC11_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA uridylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3' terminal uridylyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_260009300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="4"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC11"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0490"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000016">
        <property type="entry name" value="Poly(A) polymerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041060">
        <property type="entry name" value="Ret2_MD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF50">
        <property type="entry name" value="RNA EDITING 3' TERMINAL URIDYLYL TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18528">
        <property type="entry name" value="Ret2_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="16">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RNA editing 3' terminal uridylyl transferase 2 middle" evidence="15">
        <location>
            <begin position="188"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="14">
        <location>
            <begin position="387"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU79638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="510" mass="57865" checksum="38C65F443F6F58A8" modified="2019-04-10" version="1">MHAPTPLYLYVAVTRGLRSSAVAAPSSADAASSPSAASSSASEGVSYASHLVASKDHYEQWGRALLEENSKRIGPEQMFRTAIRAQQQLQMLADKWTPDAKIYCCGSLVTHGQMEWGSDLDLACVFDDPYPDHSVQAKRTEKLWSVVKRYMPQFLRNNLLALTEARTPVVKLRYVNDDKVARGRYTVLTEEEDRKSRTTLWDIRNRHLDSKDLEYIATKMGRENIEGIWVERTTYGCRCAVQCTSREQAIEAVGFFPDGVIMTKGMREDYTRDMLDLRYVPEMFMYKWDISFVAYGVKNSYLLRHYLHNGPPATRHAAMAAKAWGKASGVGLGTAAMLTSYAVTVMFVHYLLATRQLAWIDPWSLAHPVHMPRFPDFSPLWDCDPVELGKLLHGFFIYYAAHFNYEKNIVSLSRPRLSLRSDLNWNFPQSKQGTFSYLLGIEDPYEDVGAGGLNLGRHLHPAKFNQVKQEFARAAATMERYVPSNAPEKTILGVRRGGTSNHHHHHNRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC86</accession>
    <accession>E9BFN5</accession>
    <name>A0A3Q8IC86_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_32840</name>
        <name evidence="4" type="ORF">LDBPK_220160</name>
        <name evidence="3" type="ORF">LdCL_220007700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860766.1">
        <property type="nucleotide sequence ID" value="XM_003860718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC86"/>
    <dbReference type="GeneID" id="13389331"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0430"/>
    <dbReference type="OMA" id="MIGDEHL"/>
    <dbReference type="OrthoDB" id="272226at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057205">
        <property type="entry name" value="DUF7883"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25367">
        <property type="entry name" value="DUF7883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7883" evidence="2">
        <location>
            <begin position="383"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="841" mass="92751" checksum="AD0DC9B7AE5A0911" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICD1</accession>
    <accession>E9BG05</accession>
    <name>A0A3Q8ICD1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_2005</name>
        <name evidence="3" type="ORF">LDBPK_221400</name>
        <name evidence="2" type="ORF">LdCL_220021200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860886.1">
        <property type="nucleotide sequence ID" value="XM_003860838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICD1"/>
    <dbReference type="GeneID" id="13389609"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2000"/>
    <dbReference type="OMA" id="YVYETYS"/>
    <dbReference type="OrthoDB" id="269394at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="616" mass="68210" checksum="1B5C6E5AB64C97A7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICQ4</accession>
    <name>A0A3Q8ICQ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C3HC4 type (RING finger)/Ring finger domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_240005700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICQ4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0100"/>
    <dbReference type="OrthoDB" id="6050183at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF2">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="300"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="537" mass="58005" checksum="9AE2F646223A4B0C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID12</accession>
    <name>A0A3Q8ID12_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_280012800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID12"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0990"/>
    <dbReference type="OrthoDB" id="271972at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="479" mass="53367" checksum="5FC4B62BD456E6E3" modified="2019-04-10" version="1">MALSPESPDLNIEEPAILAYHKQADFAAFLVNEYFIKPSKQLEEARQDDTNGLLPLVSLDCLLPSGDIDKIVGHICEETHLIDERHVQQRKPFRILEKPLLIPAMLAALLHRILFEKAGVFISSTTFDLWASTALGFPARSSRLWLDACAKVEEALEESSVKQLLRKRSASDTGIHAIKRQADSKGALFSLWCSACSMLCASLTSPLLSMETCQEHFTQAVGRSISFRKDIESKTSSVMYGRGAPGFNIHAAGEPELCSCLVFHSFFRQLETLFHRAIDSKVKMNVSAHISFAVFIGCLNAFTYYRYSANKAGPVCRLLDTVAHVADGKSLTHQFDLKSVEVRQLSRYVQRASVLSSDEVFSGISHRRARKESWASSASILPRFSEMNYSTIRMTDIYPFSMVAAMGPELDDMGGCSVSADVRVHPEDEDDENFVEMTTIYLDESGDERCTQYILSAEEAASKRQVQEKLYGGKQGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDD0</accession>
    <name>A0A3Q8IDD0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epsin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250012000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDD0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0800"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03571">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="552" mass="61304" checksum="CB53A3726978CCCB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IED8</accession>
    <name>A0A3Q8IED8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_220022000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2110"/>
    <dbReference type="OrthoDB" id="10060824at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:004842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:004865">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056343">
        <property type="entry name" value="CFAP47_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058952">
        <property type="entry name" value="Ig_CFAP47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24529">
        <property type="entry name" value="CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26579">
        <property type="entry name" value="Ig_CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="392"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Cilia- and flagella-associated protein 47" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP47-like immunoglobulin-like" evidence="9">
        <location>
            <begin position="2576"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1423"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1471"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2796" mass="303539" checksum="2043839EBF445841" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEE4</accession>
    <accession>E9BJB9</accession>
    <name>A0A3Q8IEE4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_271890</name>
        <name evidence="13" type="ORF">LdCL_270026100</name>
        <name evidence="14" type="ORF">LDHU3_27.2870</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862040.1">
        <property type="nucleotide sequence ID" value="XM_003861992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEE4"/>
    <dbReference type="SMR" id="A0A3Q8IEE4"/>
    <dbReference type="GeneID" id="13386775"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2870"/>
    <dbReference type="OMA" id="MLHNINR"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000049">
        <property type="entry name" value="Small nuclear ribonucleoprotein-associated protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU80089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5431316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11818" checksum="AA89359CC5B08952" modified="2019-04-10" version="1">MGKYTMLHNINKVLCVMLDDGRTVTGKLLVFDKHMNVVLGDAVEERPQSKKMAEEGVSPKRQLGLILLRGEHVVSVTVMKGSENGGSGAVANFGGAPKSAKATAVKRKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEV9</accession>
    <accession>E9BRT9</accession>
    <name>A0A3Q8IEV9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_5880</name>
        <name evidence="3" type="ORF">LDBPK_350620</name>
        <name evidence="2" type="ORF">LdCL_350011100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864650.1">
        <property type="nucleotide sequence ID" value="XM_003864602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEV9"/>
    <dbReference type="GeneID" id="13387528"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0760"/>
    <dbReference type="OMA" id="LPYGTLW"/>
    <dbReference type="OrthoDB" id="272841at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41263" checksum="99E8A5213FCBCF2F" modified="2019-04-10" version="1">MLPYGTLWKLDEMLHAAAPPPRRTAAMRRRQALFYFFWGISLVSVFLVPFHYASLRRLRIDSERELLGLVAPTVDLTQLHMRQDQALQRLRAWSTARWVDKHPDRCEDDNVGDADVTADFALAFYLHPLSRTRLDGVFAHPYVRAVAGGGVGVLWPRLGDAAEARDALQHVPRARTLSEVAVDAAKDPSNPAKCLIALRRDRLQAGAEGINYEEEKDDLIKALQETLSQEAGLYRINVGGPSDAAKVAVDAVDGQAATDNVLAALLLWLAGRHKCSHAQEEAISRALAACQAPLSRSLRMSFDWSAAPGAARAMTPIVATVQEEEAAPQYLCLCSKHGVQPPAALVEPSSGTATSLFLVDPARLEASTQTCADACLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEX7</accession>
    <name>A0A3Q8IEX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heat shock 70-related protein 1, mitochondrial, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Heat_shock_70-related_protein_1_mitochondrial_pre cursor_putative/GeneDB:LmjF.30.2460/GeneDB:LmjF.30.2470/Gen eDB:LmjF.30.2480/GeneDB:LmjF.30.2490/GeneDB:LmjF.30.2550</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_300030300</name>
        <name evidence="12" type="ORF">LdCL_300030400</name>
        <name evidence="13" type="ORF">LDHU3_30.3350</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEX7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3350"/>
    <dbReference type="OrthoDB" id="276171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000026">
        <property type="entry name" value="Heat shock 70-related protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="549"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="627"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU81048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5432273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="661" mass="71816" checksum="6C4862010FB09222" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEZ8</accession>
    <name>A0A3Q8IEZ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310029800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEZ8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3890"/>
    <dbReference type="OrthoDB" id="265592at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="763" mass="82359" checksum="CE5D554FFD25B802" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFA0</accession>
    <name>A0A3Q8IFA0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_310017700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFA0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310017700"/>
    <dbReference type="OrthoDB" id="10380202at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12223" checksum="43704348B4CCBA61" modified="2019-04-10" version="1">MPERIKAATLTDALPRTTTPAEATTMRPARCAAVKAPSSALAWCDRIAPSILSQVAAAEGVFVRFPASRYMYPLGYLLPASRPPSFSTLLLASRMGSIATHRPPCIPTCGCTSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG00</accession>
    <accession>E9BMI2</accession>
    <name>A0A3Q8IG00_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter aATP11, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_12015</name>
        <name evidence="8" type="ORF">LDBPK_310590</name>
        <name evidence="7" type="ORF">LdCL_310011400</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863149.1">
        <property type="nucleotide sequence ID" value="XM_003863101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG00"/>
    <dbReference type="GeneID" id="13385870"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0850"/>
    <dbReference type="OMA" id="INICAAM"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF690">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="75"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="472" mass="51140" checksum="98A52BA9AD7CDA8F" modified="2019-04-10" version="1">MKAVEATRVSSTVLAQDIPREVDADAEELAEMDVADGNKVPAHVCPDDSFHSKDRGNRDLSTIGRLLQVMIPYGGMLSSSFSMASTTIGAGILGLPAAFHSVGIIMATVYLVLITAETVYSMRLLVQVSEKTGLRSFEEMAKQLLHPRANIFVAIIRALHIFGGSVAYVVTIGDLLKPILSSSASTPPFLLTSIGLKLLTTGFWLVFMFPLVLLRRINSLRYVSAFGILFILYLALVVITHSAMNGMRARPRPTTRLISTGNMAIEGLGVFIFSYMCQINCLEVALEMRPRSLGRFTICAAVSMTICGILYYATGLFGYLDFGEMRGSILLRYNPLQQPHVFVGYVGVFIKICASFGLLNNACRSALFPLIGWDPYTVVYWKYLIGAVSLAVLVLMLGLFVPNVNIVFGFTGGVCGGFVGFILPALFVMYAGGWSFRSVGVINYCCTYLVLAAGVVAVVFGTAATIYSVATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG20</accession>
    <name>A0A3Q8IG20_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate aminotransferase, putative</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Glutamate-oxalacetate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">got</name>
        <name evidence="8" type="ORF">LdCL_350013200</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="Int. J." volume="50" first="1079" last="1088">
            <title>The Leishmania donovani species complex: A new insight into taxonomy.</title>
            <authorList>
                <person name="Fernandez-Arevalo A."/>
                <person name="El Baidouri F."/>
                <person name="Ravel C."/>
                <person name="Ballart C."/>
                <person name="Abras A."/>
                <person name="Lachaud L."/>
                <person name="Tebar S."/>
                <person name="Lami P."/>
                <person name="Pratlong F."/>
                <person name="Gallego M."/>
                <person name="Munoz C."/>
            </authorList>
            <dbReference type="PubMed" id="32889062"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">MHOM/LK/2002/L80</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN728716">
        <property type="protein sequence ID" value="QNM36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG20"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1020"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="38"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QNM36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="412" mass="46102" checksum="0121C83F96BE8D4C" modified="2019-04-10" version="1">MSTQAAMTTTERWQKIQGQAPDVIFDLAKRAAAAKGPKANLVIGAYRDEQGRPYPLRVVRKAERLLLDMNLDYEYLPISGYQPFIDEAVKMIYGDTVALENLVAVQTLSGTGAVSLGTKLLTRVFDAEKTPIYLSDPTWPNHYGIVKAAGWKNICTYAYYDPKTVSLDFEGMKKDILAAPDGSVFILHQCAHNPTGVDPSQEQWDEIASLMLAKRHQVFFDSAYQGYASGSLDTDAYAARLFARRGIEVLLAQSFSKNMGLYSERAGTLSLLLKDKTKRADVKSVMDSLIREEYTCPPAHGARLAHLILSNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGSWEHVINQIGMFSFLGLSKAQCEYCQNHNIFITLSGRANMAGLTHETALMLAQTINDAVRNVDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG86</accession>
    <name>A0A3Q8IG86_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360037900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG86"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4340"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002674">
        <property type="entry name" value="GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008956">
        <property type="entry name" value="PRK12299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="5">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="173"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="487" mass="53515" checksum="0AB08CF015CFBF23" modified="2019-04-10" version="1">MLRRRWGAHRAKHRFVDRVKVLLCSGAGGDGASIMAHEHGNEFAGPGGGNGGNGGNVMLQCVKQHTDLSHIEDLGSQISAGAGFCGFSREAHGKRGQDLWLQLPLGTQVVDMDTNEVQYDMDEEGMQIVLLEGGQGGKGNAAFANKWHHSPIESTKGLPGNTMLAQIELKTIADCGLIGYPNAGKSSLLSAISASKPTIAPYAFTTLRPYVGVLHDLYGNVCRVADIPGLIEGAYENRGLGHQFLRHVERTKCLALVVDMCDTYVPDTGSRNSSEVLQPWDVVELLLQELEYYLPDMSQRVIMTFANKMDIEKDSTGTDTQVKLSELKRRVSMPVFPISAALGIHLGPQHEQTGLAPALQFMCREVFARQSHEREMQQFRFSHERAQLERAFRAKHNGVFLPQVHALGAHGAEASQDLDDEAASRGGSLVDQQLDFLGNSGLGVEFDAYENSAARGQLHRYRDLTMKGKYWNLTRQDGEVMKGEKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGY0</accession>
    <name>A0A3Q8IGY0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_340008100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0440"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="489"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1552" mass="172297" checksum="522AB80B20BA6456" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH61</accession>
    <name>A0A3Q8IH61_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LdCL_100010900</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH61"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0710"/>
    <dbReference type="OrthoDB" id="264225at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU76663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="589" mass="62696" checksum="E9888325EBE91289" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHS3</accession>
    <accession>E9BPR5</accession>
    <name>A0A3Q8IHS3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like peptidase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Trypsin-like peptidase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_5585</name>
        <name evidence="2" type="ORF">LDBPK_333280</name>
        <name evidence="1" type="ORF">LdCL_330040400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000051">
        <property type="protein sequence ID" value="TPP42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864151.1">
        <property type="nucleotide sequence ID" value="XM_003864103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHS3"/>
    <dbReference type="GeneID" id="13392547"/>
    <dbReference type="KEGG" id="ldo:LDBPK_333280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330040400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4760"/>
    <dbReference type="OMA" id="ATCYHGM"/>
    <dbReference type="OrthoDB" id="240599at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="305" mass="32858" checksum="B9A73F23129D2BF7" modified="2019-04-10" version="1">MAEGAAAVGGAGVLAAASQWRGCCYPILTFLHVPGKMTKPLWLMMGTAFTFRTHEMVEATYGQPAAPSSLLLTAKHSFSPWDYTKDASQLKIPKEYQKPRFVIGRVYRTDADGRAVAADAVGLRLLAHHPIHDVALLAVDAASLKLLQCATYDSPAHALDLAHEALPLCKEPYPAASDGLLIGFRGAGRLGELDTLDPSVLQRLPPHEREALIKDLQDVEGKQRRATTTVSVLDARGMCKGVGDLATCYHGMSGGPLVTTNGQCAGVLYGHHPDAPGCIGYTPCADFAGWLEEEVQRYRKRCDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II14</accession>
    <accession>E9BBH4</accession>
    <name>A0A3Q8II14_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC21_33425</name>
        <name evidence="16" type="ORF">LDBPK_131000</name>
        <name evidence="15" type="ORF">LdCL_130015300</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859311.1">
        <property type="nucleotide sequence ID" value="XM_003859263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II14"/>
    <dbReference type="GeneID" id="13390501"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1220"/>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000075">
        <property type="entry name" value="Putative leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="686"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="807"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="14">
        <location>
            <begin position="949"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122151" checksum="D28D3C7BEBAA8346" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIL7</accession>
    <accession>E9BT75</accession>
    <name>A0A3Q8IIL7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_29840</name>
        <name evidence="4" type="ORF">LDBPK_360150</name>
        <name evidence="2" type="ORF">LdCL_360006300</name>
        <name evidence="3" type="ORF">LDHU3_36.0210</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865133.1">
        <property type="nucleotide sequence ID" value="XM_003865085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIL7"/>
    <dbReference type="GeneID" id="13388018"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0210"/>
    <dbReference type="OMA" id="WFVTERV"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="644" mass="69903" checksum="2F3370D3CBD86646" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIN3</accession>
    <name>A0A3Q8IIN3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340033000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIN3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4140"/>
    <dbReference type="OrthoDB" id="261850at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057608">
        <property type="entry name" value="PH_2_kinetoplastids"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25406">
        <property type="entry name" value="PH_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="2">
        <location>
            <begin position="259"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="451" mass="49863" checksum="5D7F83D89EC585D5" modified="2019-04-10" version="1">MSSRRGRQWQSPSGGDDNGLRRDSSARYSSSAHTKSLRYGNGGGFRSNDSRRTVDTSDRYCDMYTLQWGCASSSDGARTARIGEVQVGSTSRDCRRRDASRGSGVSGPGARGRSVRGGNRQYDAPSSWSTSSYTYSYSGSDANNGDSSSEERARDQNRVYAGSRARKRQETKSSRPTPLGSARSPIRVTPTGPPPLDAPPPGAIRWVDDGRRGREVYRGENESKAGSLSRQHTDADEQDAAMMKPAASLRPLLSARTPSLQPTGMLRRVIAAVAYYRGVPPPPSVPPEVILAFDEYVSRGSVMLKFASRGPPHQRFFAIRFLDVMAGSIRLGCGRAYDQRPSILHAVLSWYRSASSRRMIRFLPLHDLIEVKADGADHRYVRRRTVQPGLLRGPRSGLVTTYVRADFIVQFRFCSRLSRAEETLALMAENRTQYLAWLVVGSFISQIGEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIX7</accession>
    <accession>E9BT80</accession>
    <name>A0A3Q8IIX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Elongation factor Tu GTP binding domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Elongation_factor_2/GeneDB:LmjF.36.0180/GeneDB:Lm jF.36.0190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_29810</name>
        <name evidence="18" type="ORF">CGC20_29815</name>
        <name evidence="16" type="ORF">LDBPK_360210</name>
        <name evidence="8" type="ORF">LdCL_360006700</name>
        <name evidence="9" type="ORF">LdCL_360006800</name>
        <name evidence="10" type="ORF">LdCL_360006900</name>
        <name evidence="11" type="ORF">LdCL_360007000</name>
        <name evidence="12" type="ORF">LdCL_360007100</name>
        <name evidence="13" type="ORF">LDHU3_36.0280</name>
        <name evidence="14" type="ORF">LDHU3_36.0290</name>
        <name evidence="15" type="ORF">LDHU3_36.0310</name>
    </gene>
    <organism evidence="8 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865138.1">
        <property type="nucleotide sequence ID" value="XM_003865090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIX7"/>
    <dbReference type="SMR" id="A0A3Q8IIX7"/>
    <dbReference type="GeneID" id="13388023"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0310"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="274892at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5434587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5434589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ38459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="845" mass="94147" checksum="6B3DDE076B0CD337" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJG9</accession>
    <accession>E9BU21</accession>
    <name>A0A3Q8IJG9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_28420</name>
        <name evidence="4" type="ORF">LDBPK_363120</name>
        <name evidence="2" type="ORF">LdCL_360037600</name>
        <name evidence="3" type="ORF">LDHU3_36.4310</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865427.1">
        <property type="nucleotide sequence ID" value="XM_003865379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJG9"/>
    <dbReference type="SMR" id="A0A3Q8IJG9"/>
    <dbReference type="GeneID" id="13388313"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4310"/>
    <dbReference type="OMA" id="QAYCAGA"/>
    <dbReference type="OrthoDB" id="257896at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="171" mass="19324" checksum="1DB47DE308F54F26" modified="2019-04-10" version="1">MWGLSITRVFQVYCAGAALFEVPGIVRLLSGDMPLPKAGAWVDDKNYYTDNKPLVYVFVAILACLVVSRGMACALPKSRIIIVYLVVVHTFEAGLYLYCCSHKEDAPDSEVCIMGMLMVVNISLFAARLVQLKVQHTRVEIADLKRRQEQLAIIRKKRADYAKNREEKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKQ4</accession>
    <accession>E9BNG8</accession>
    <name>A0A3Q8IKQ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_33635</name>
        <name evidence="11" type="ORF">CGC21_19880</name>
        <name evidence="10" type="ORF">LDBPK_320640</name>
        <name evidence="9" type="ORF">LdCL_320011900</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863482.1">
        <property type="nucleotide sequence ID" value="XM_003863434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKQ4"/>
    <dbReference type="GeneID" id="13390294"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0790"/>
    <dbReference type="OMA" id="WAPCVGR"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP43577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP47072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="363" mass="39586" checksum="0220C3B93F176C56" modified="2019-04-10" version="1">MSSLVTQHKTYVHHVSLDPSGSLLASCSSDKTVEVFHRRTLTGGGAVWEPGCAMHDHSGPVLRMAWCQHREHGPLLATAGADRWIYIYRIIISSHEGRTLLHTVRWSPVRGYEKDVITDVAFVPPQQYHALLLSTASLDGCVRLYEVHQPQQFPCVCRISPEADAAAEGASDSAACAVGVSAGSAAAERREDASASQSASSVPLLRSGGVTAIGWFPGSAERTMTLAVGTVSGRFFLYRYIKDSNSFMTISLPQVEAGVLRCSAPVCNVSWASCVGRRFQLLSICSRSEVFILRLNCVSPSIDEKRSFELFRVPFGAVSASWGRSSTLLYLATDDQRTQVVVLQMANPLDHQSWRVVSRNAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILD3</accession>
    <accession>E9BV31</accession>
    <name>A0A3Q8ILD3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_366750</name>
        <name evidence="2" type="ORF">LdCL_360075800</name>
        <name evidence="3" type="ORF">LdCL_360076100</name>
        <name evidence="4" type="ORF">LdCL_360076400</name>
        <name evidence="5" type="ORF">LdCL_360076700</name>
        <name evidence="6" type="ORF">LdCL_360077000</name>
        <name evidence="7" type="ORF">LdCL_360077300</name>
        <name evidence="8" type="ORF">LdCL_360077600</name>
        <name evidence="9" type="ORF">LdCL_360077900</name>
        <name evidence="10" type="ORF">LdCL_360078200</name>
        <name evidence="11" type="ORF">LdCL_360078500</name>
        <name evidence="12" type="ORF">LdCL_360078800</name>
        <name evidence="13" type="ORF">LdCL_360079100</name>
        <name evidence="14" type="ORF">LdCL_360079400</name>
        <name evidence="15" type="ORF">LdCL_360079700</name>
        <name evidence="16" type="ORF">LdCL_360080000</name>
    </gene>
    <organism evidence="2 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 19">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865786.1">
        <property type="nucleotide sequence ID" value="XM_003865738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILD3"/>
    <dbReference type="GeneID" id="13386640"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360075800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360076100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360076400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360076700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360077000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360077300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360077600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360077900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360078200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360078500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360078800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360079100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360079400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360079700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360080000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8960"/>
    <dbReference type="OMA" id="GHQSHRD"/>
    <dbReference type="OrthoDB" id="267742at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU84044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU84059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU84071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU84080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="469" mass="50726" checksum="0E8D90578A27263D" modified="2019-04-10" version="1">MSSALQPSPPALQRSKLGVSGTTSDDSTHNGQLETFLRERLENWDKEAAEVIMVWGRLGGMCSSEYQSQLRKARTTLSETNKKEKRRDTSALQARDDSKTDGHQSHRDRLAAEYWARTQAKLNAAQQQRGRQLRRQQRLQANGQAPVSLSSVSQRTPPVFSGQVHTLRAASTSVSPRLTAARGQYVPLTPAPPTSPPCSSRRASGGGVAQRGAPSVRKVKQKARNSEDIHKHKELTAPLNERRDFTLSGAGSEGSDGSSSLILSTTDEEQVSAVASTPTAATSQPSSSFSGTFIVRRRLSVHGQPSSSSTVAFQHTVQRSHSMTSSPRSVAPPPPQPAHQTCQRSSSTTSDATQEDRADGKVNAPSSVSTVDPSLPFHSRTVTAIFTYSSRSREKTSGPRRRRSTQERRLDNSAHTEQPRGEPDAEAQESASNAPSQTVSPIKKDSHADDLSSVSSAASYLNRGVLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMQ9</accession>
    <name>A0A3Q8IMQ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_10015</name>
        <name evidence="10" type="ORF">LdCL_330036200</name>
        <name evidence="11" type="ORF">LDHU3_33.4060</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMQ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330036200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4060"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5433498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP55409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="241" mass="26058" checksum="F6C605F768B356F6" modified="2019-04-10" version="1">MPLTAAGMRTLMRQMQEVQEHPVDGVQVRPADSMNEYHFDLDGPEGTPFAAGRFHVALIFDEQYPEVPPKGFFRTKIFHPNISERGDICVNALKRDWAPTLGLRHILVVIRCLLIEPNPESALNEEAGRLILEEYAAYERKAAMYTTINAARPNGVPRFTLPEVQAEKASSLVTADASAPVAGESGASSTTAAASASSMANGSTPSTATRRLTLSEANCHPGAATAAEKAEKSKKKALRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IN13</accession>
    <name>A0A3Q8IN13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240029800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IN13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2980"/>
    <dbReference type="OrthoDB" id="266839at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="257" mass="30935" checksum="5D08BEB67D884C78" modified="2019-04-10" version="1">MEAHGTDERARGVSTFTRADLELREAAEDHRAFLAEKWASYAVRKGYSEGEEHTKWITETWEAFEKRKAAQKLYLERHDLLSEYKAAQLSEARRLSERKSAVVEKMMALEAARKCTLLQPRHFLFVNYYDYQQFLFRNQRSFVENEEKLLRCKLFETEDDLMCLLVTQWHLSSHLHAAREKERVEEETAAERLRELQYRQKLEEERLLEEQRIAQEKEAAQAEKEQAELEKRLERKRRDEERRAKVRAEREQRIAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IR44</accession>
    <name>A0A3Q8IR44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290010100</name>
        <name evidence="3" type="ORF">LDHU3_29.0760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IR44"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0760"/>
    <dbReference type="OrthoDB" id="263994at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="232" mass="24303" checksum="8505EE4DA8049F80" modified="2019-04-10" version="1">MQAAAPGQTLSSVLSFWADVSYGDAPPAALIDYPPLGFEEDSSRLTVEALQASRDAAAAEGRRQLGRKTQRASEDADGPAHPALLLGVEEESSTVTVTREGLEGEEGPAWLQPPLLLQMDDGLKDRQFAAATTAGRMAPVPHLRYEGAGLLAVVYVHSSGIAYVGYPHASDTASSAEPTDGLVRRPDDEPPVDPLAVAPPTPPSWQQLPPAPICSLPMSSSTGFVRGLLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4W2</accession>
    <name>A0A3S5H4W2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_010011500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4W2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0730"/>
    <dbReference type="OrthoDB" id="267989at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="706" mass="74244" checksum="6E82F6EA6D9E0C5C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Y5</accession>
    <name>A0A3S5H4Y5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_020006500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0210"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU75615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1969" mass="203836" checksum="704CCC918CCE1BFC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5E0</accession>
    <name>A0A3S5H5E0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5E0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1230"/>
    <dbReference type="OrthoDB" id="273342at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1241" mass="133014" checksum="07D51DA037E4FAB7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5R8</accession>
    <name>A0A3S5H5R8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060012000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0810"/>
    <dbReference type="OrthoDB" id="267542at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1303" mass="132772" checksum="63C7DB97EB28A271" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H686</accession>
    <accession>E9B9J9</accession>
    <name>A0A3S5H686_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_22940</name>
        <name evidence="15" type="ORF">CGC21_0100</name>
        <name evidence="14" type="ORF">LDBPK_081000</name>
        <name evidence="12" type="ORF">LdCL_080015500</name>
        <name evidence="13" type="ORF">LDHU3_08.1380</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858658.1">
        <property type="nucleotide sequence ID" value="XM_003858610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H686"/>
    <dbReference type="GeneID" id="13391939"/>
    <dbReference type="KEGG" id="ldo:LDBPK_081000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1380"/>
    <dbReference type="OMA" id="CFDARML"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09992">
        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="201"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU76407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5427757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP54920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="609" mass="66115" checksum="6AA0C5FECB96DD8A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H690</accession>
    <accession>E9B9K7</accession>
    <name>A0A3S5H690_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiopurine S-methyltransferase (TPMT) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Thiopurine S-methyltransferase (TPMT), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Thiopurine_S-methyltransferase_(TPMT)_putative/Pf am:PF05724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_22905</name>
        <name evidence="9" type="ORF">CGC21_0065</name>
        <name evidence="8" type="ORF">LDBPK_081070</name>
        <name evidence="6" type="ORF">LdCL_080016300</name>
        <name evidence="7" type="ORF">LDHU3_08.1520</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858666.1">
        <property type="nucleotide sequence ID" value="XM_003858618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H690"/>
    <dbReference type="SMR" id="A0A3S5H690"/>
    <dbReference type="GeneID" id="13391943"/>
    <dbReference type="KEGG" id="ldo:LDBPK_081070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1520"/>
    <dbReference type="OMA" id="FRQIHLH"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000436">
        <property type="entry name" value="Thiopurine S-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5427765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP49040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP54913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="426" mass="48112" checksum="53C9109A3A54B749" modified="2019-04-10" version="1">MLRTTRLRRIGVHIPSAKELDDQVLINRLRKSRPKSVFSLKALTTGRVQGFVAAGGIVLGTAMFLGPWLWEEVQELMGSRYVPLAPSQMPHTSPEWWENEWRKMNPLWRAGESMSDFFVGPYRFVKEQTGRDMSSAADFVRTSPSSSLSSFGAAGEQQRSFLHRLKQVFHRSASLTTSTCVTTASSGVGAASKGGHSRRATASAVMLPNPPQMLVPLCGDSPIMRTAALQGFEVDAVDSSQTAIQTAVGRTEEGLPQEFYSKIHLHWKNFFSPELWEGPLKGKKYDVIYERQGMTSLNREQRPDYAYLLKRAMKDDGLIYVEGVFRTGRVKGNKLMGPPYSLSKRELQQLFPLSEGYYVRCEEKTDAMQQLSRENRILKRVPKELYVTPFSCVVFRESTVNLRTRTEPLQHPEPPTLTPPQEGFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6B6</accession>
    <accession>E9B9Q8</accession>
    <name>A0A3S5H6B6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NRDE protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NRDE_protein_putative/Pfam:PF05742</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_090220</name>
        <name evidence="1" type="ORF">LdCL_090007300</name>
        <name evidence="2" type="ORF">LDHU3_09.0300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858701.1">
        <property type="nucleotide sequence ID" value="XM_003858653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6B6"/>
    <dbReference type="GeneID" id="13392030"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0300"/>
    <dbReference type="OMA" id="CERFPFI"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="503" mass="53631" checksum="59479E20856AB657" modified="2019-04-10" version="1">MCILAFITRHCERFPFILIGNRDEELARVTGGLTLDTSTGLVWALDRRAGGSWMGIEPRSGRFAILTNCRRSPAAPLTCSAKARDAGQCGGSERGEPAQRAGLFTAAAVWRGAAPLSHICAHTTVVPVTALPTVLATAKTAAEDSRCPQHSKQLRTVTLAYDPPTSRGLVIKNFLQTGILPGDTAQTPMGCTRSEDADASLGKDDALVAALPAVLRVPPYYAGFNLLSCDDLRRCGVDAVASEHGRHESGNTSAAAPEILYTTNRYTAEHRCPVAPGQVHCLQNSYLDNMHGEPITARLGQLFTDALHRVIDPIAAEQPPSSTSGITPAMVTEVATALADECLCDRCSFDLPKMEKTAFSAAAAAALHAQLHSNNPLLGFTEKELHEYFGNSAAGDEDDVSVRFCDGGAATREAYLQSSIFKLPFRGYGTQMQSMVLVERVAAVPSTLSNVVSSASATTVIHFCQRKVSFDVATQSVVAAPWIAYRILQDGSCLRDSAEIPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J3</accession>
    <name>A0A3S5H6J3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_0775</name>
        <name evidence="8" type="ORF">CGC21_0780</name>
        <name evidence="5" type="ORF">LdCL_110015400</name>
        <name evidence="6" type="ORF">LdCL_110015500</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J3"/>
    <dbReference type="SMR" id="A0A3S5H6J3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1200"/>
    <dbReference type="OrthoDB" id="256667at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP53004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="190" mass="21298" checksum="0BFE730148235E89" modified="2019-04-10" version="1">MSSKTPKLFNKWSFEGLETSELALRDHISTTAAYVPHTSGRWQKRRFYKARMPIVERLANGLMFKGRGNGRKLQAARLLKHTLEIIHLLTDENPLQVVVDAVSKGAPREDSTRVGSGGVVRRQAVDVSPMRRVNEAIYQMCKGAREAAFRNLKSMPECLADEIVNASKGSSNSYAIKKKDEVERVAKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6K1</accession>
    <name>A0A3S5H6K1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_120005200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6K1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0050"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000073">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 8 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="283" mass="30279" checksum="3FF06E8B1E06F23F" modified="2019-04-10" version="1">MLQRPDHTLLQDPSYPKDIEQKLTENGPAQAGKQLFQPDLAVIDPQLSEAVSLGTTILAVSYKGGVVLAADSRTSSGTYVVNRASNKLTKLTEKIYCCRSGSAADTQALAERVSNYLGSYQTDIGADVNVATAANLFHKMCYVNRWNISAGIIVAGYDPINGGSVYSIPSGGSCVKLDYALGGSGSIFLYSFFDANYKPGMSKSECVAFCQCAVAHAYSRDGSSGGLIRTITLDAEEAEDLTVPWKRSPYCMEKDPKYQVQAVQNPPFSSSAKVTGNRMSSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6P5</accession>
    <name>A0A3S5H6P5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="9">AMPSase</shortName>
            <shortName evidence="9">AdSS</shortName>
            <ecNumber evidence="9 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_130016200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="9 10"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6P5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1340"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000005">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000003">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="563"/>
            <end position="569"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="697"/>
            <end position="699"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="710" mass="78492" checksum="6D9355DF63CFCECA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7A1</accession>
    <accession>E9BFG6</accession>
    <name>A0A3S5H7A1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_34530</name>
        <name evidence="4" type="ORF">LDBPK_211800</name>
        <name evidence="3" type="ORF">LdCL_210023800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860697.1">
        <property type="nucleotide sequence ID" value="XM_003860649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7A1"/>
    <dbReference type="GeneID" id="13386534"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2130"/>
    <dbReference type="OMA" id="FETNTHE"/>
    <dbReference type="OrthoDB" id="273279at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="544" mass="59729" checksum="F13955178E604403" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7A9</accession>
    <name>A0A3S5H7A9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IQ motif and ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220014600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7A9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1180"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037695">
        <property type="entry name" value="IQUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057887">
        <property type="entry name" value="IQUB_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074:SF0">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25805">
        <property type="entry name" value="IQUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IQ motif and ubiquitin-like" evidence="2">
        <location>
            <begin position="703"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="IQ motif and ubiquitin-like" evidence="2">
        <location>
            <begin position="826"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="930" mass="100303" checksum="0B345C13D06862CC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7J2</accession>
    <accession>E9BJL0</accession>
    <name>A0A3S5H7J2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_22165</name>
        <name evidence="12" type="ORF">LDBPK_281390</name>
        <name evidence="10" type="ORF">LdCL_280018500</name>
        <name evidence="11" type="ORF">LDHU3_28.1750</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862238.1">
        <property type="nucleotide sequence ID" value="XM_003862190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7J2"/>
    <dbReference type="GeneID" id="13386974"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1750"/>
    <dbReference type="OMA" id="FHDEVYR"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000007">
        <property type="entry name" value="Phenylalanine-4-hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000115">
        <property type="entry name" value="Phenylalanine-4-hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="111"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5431520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP54274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="452" mass="51521" checksum="69F69ACC78B7EF38" modified="2019-04-10" version="1">MLLRSRLFLEAGMAAAATLKDQYASSGSNIKGADKKTRCRTSLQVSLSTDKPGELCHLLSVFKPYSINISQVANRPRAYENKAPLRTIFLDVDAYIEDESMKKVMTELHAKFPNVVVAGSWVIPWYPTEPKDLDELDQSTLAAGEELQEDPENPHPGFHDEVYRARRREIVGLAKNYKTGDQIPIVNYTEEENRVWTVVYDHLTRLYPTHACQQYNYVFPLLLENGVLSRTQTPQLRDVSEFLNEATGFTVRPVTGLLTSRDFLNALAFRVFYSTQYIRHAAQPLYTPEPDMVHDIIGHLPLLSDPDFANFTQTIGLASLGASDELLDKLAKVYWYSVEFGLCSEGGRRKAYGAGILSSCGELEYALSDKPECVPWDPTMASKTPFPITKYQPRYFVAESFSDAQRKLETWLSSQEKPLYTVYNSYSRRVQSYPKNTWNMLQEQMKRTNFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7L5</accession>
    <accession>E9BKZ1</accession>
    <name>A0A3S5H7L5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tob55, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Tob55_putative/GeneDB:LmjF.29.1820</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_291940</name>
        <name evidence="7" type="ORF">LdCL_290025100</name>
        <name evidence="8" type="ORF">LDHU3_29.2780</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862612.1">
        <property type="nucleotide sequence ID" value="XM_003862564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7L5"/>
    <dbReference type="SMR" id="A0A3S5H7L5"/>
    <dbReference type="GeneID" id="13385315"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2780"/>
    <dbReference type="OMA" id="WISMGIF"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000013">
        <property type="entry name" value="Putative Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="253"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5431905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="473" mass="52562" checksum="5986085BF240C161" modified="2019-04-10" version="1">MTDTTQQTVNICEDDLSAALKMPIRAHVRLVGIERTHPDVVARDLETIKRCRTMQEAVEAITEIRSRWISAGIFRNVKYNFEPTADGERNDICVRLDVIEEKPKKSIGVFTTDASIPEITVALENILGGRYSVKGNYIPPASRIHSISFSFLSNVPLIGQSAEYYIGRKTENKTYHLANSERVEEVKATTTNRKGKLASEFSVGLQRRTLLTKHMKNIPVEDAVDFSATDKGYARHQLTMTDVAHHANPFLYNMYPLPIYGSQISLCNEFAGGPMGGDFTFLKSEFQGSKYIPLGPFFSLQLSAKLAGIYPFFGSRIPLNDRLFLSNCHVRGFKSVGPSTFDWGGNASRFAATGGNALWATSLSLNFPFLFFPNNGIASMHLFANAGHVRMMESLDALKDGYRWLRDCACSVGAGIVITRIPIFGVAPSGRFELNMSIPLGIDKQGNIVCRNGPKSLFDRFRFGLVWSFSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7R4</accession>
    <name>A0A3S5H7R4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320012800</name>
        <name evidence="3" type="ORF">LDHU3_32.0900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7R4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0900"/>
    <dbReference type="OrthoDB" id="262635at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="186" mass="19513" checksum="B854F124CFBD8431" modified="2019-04-10" version="1">MGCEVSSIKGKEAKRAAPKKTKQRSGNAKAGPENASPSKMGETTLQTTGVTNLSSKDPLKTDVPCTSDSLIALMPGTCAGDMHQQPPATNADLSRSDSITNEDLNGSLCVDLSGSFRMPNSNKGDIALNTKAPEARRSRSVSQVLLKSVSPHPSDNDLVLICIDCGMEISENCESVLCPLTGKAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H802</accession>
    <name>A0A3S5H802_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RAD2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_350041400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H802"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4780"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000113">
        <property type="entry name" value="DNA repair protein RAD2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF59">
        <property type="entry name" value="FI23547P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="5">
        <location>
            <begin position="647"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="930" mass="98970" checksum="C7D4FDCC898725C4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNU5</accession>
    <name>A0A3S7WNU5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30-like ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_040014200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNU5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1080"/>
    <dbReference type="OrthoDB" id="9973389at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019111222" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="74"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU75866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24385" checksum="D888A2B1DE91A019" modified="2019-05-08" version="1">MLRLLRCITASPAVAASVAVAAAQTPTSLRPAAVCRRDVHLTPSVLAAAPASTATSTTTIAAGPYRRVGNVFIVTCIDHPFKFSWEVNRMLRELRLEFMGQTTVVPDIPSVRKRIWRVRHVVRIDQLDLDEAKALIGIPEHISFRDLAAQIPPTFGRGGSVANPHMRSKMNFMRLRRMRLRDVMHRDQLEKRLLEEKRHALQQQQQGGGGAAAAAAAATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNX4</accession>
    <name>A0A3S7WNX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040015900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNX4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040015900"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6931" checksum="2DE8470F3193CE81" modified="2019-05-08" version="1">MHGEGERTLKRQSAQAVATKHSRRPSVESRSVMERARGQRVPSPRASPPSGNVGCHRSPHHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR46</accession>
    <name>A0A3S7WR46_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LdCL_100011600</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR46"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0720"/>
    <dbReference type="OrthoDB" id="264225at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000003">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU76670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="599" mass="63870" checksum="1D71FEA34652944E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRX6</accession>
    <name>A0A3S7WRX6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCR4-NOT transcription complex subunit 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_120008600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRX6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0470"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000019">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="383"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="564" mass="60822" checksum="3C4D878CA187326D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WS99</accession>
    <name>A0A3S7WS99_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_130006300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WS99"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0170"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF4">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="31"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="14">
        <location>
            <begin position="429"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="9">
        <location>
            <begin position="429"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="563"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="122"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="726" mass="79139" checksum="325AD6023B9C2FD7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSB8</accession>
    <name>A0A3S7WSB8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase (Class 3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_130007000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSB8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0250"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47413">
        <property type="entry name" value="LIPASE-LIKE PAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47413:SF2">
        <property type="entry name" value="LIPASE-LIKE PAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="747" mass="81881" checksum="AC987611B9232283" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTI0</accession>
    <name>A0A3S7WTI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase/GDP dissociation inhibitor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150014200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTI0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1120"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000654">
        <property type="entry name" value="Rab geranylgeranyl transferase component A, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113670" checksum="6E70EC08FF0B62BD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTP8</accession>
    <name>A0A3S7WTP8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_160005500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTP8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0060"/>
    <dbReference type="OrthoDB" id="278079at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="399"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="657" mass="73577" checksum="BBC658FB3FDC1564" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU10</accession>
    <accession>E9BCX0</accession>
    <name>A0A3S7WU10_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_161160</name>
        <name evidence="2" type="ORF">LdCL_160016700</name>
        <name evidence="3" type="ORF">LDHU3_16.1430</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859803.1">
        <property type="nucleotide sequence ID" value="XM_003859755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU10"/>
    <dbReference type="GeneID" id="13393139"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1430"/>
    <dbReference type="OMA" id="ADVCSAY"/>
    <dbReference type="OrthoDB" id="240850at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="157" mass="16860" checksum="B1D7A17FA9EA1095" modified="2019-05-08" version="1">MRRLSGSPMASSAHEAADAGSGDVDMAGVQVLESSVDFMSLFYCHLTSCPPHGPFVYYAAMTLLRRAKRRYGASGSNSVTGADVCSAYASWSNDAMGSDGAAAVLRALTIPNVMALIEKRYDTSHLSNWPLLYVPAEIRSADVDALIQQRQQQPQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU82</accession>
    <name>A0A3S7WU82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160016400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1390"/>
    <dbReference type="OrthoDB" id="267484at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1726"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1886"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1924" mass="197821" checksum="27982ECE9A83446F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW37</accession>
    <name>A0A3S7WW37_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA editing endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW37"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1120"/>
    <dbReference type="OrthoDB" id="245613at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23728">
        <property type="entry name" value="ZF_RNaseIII_KREN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000028">
        <property type="entry name" value="RNA editing complex protein MP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39671:SF2">
        <property type="entry name" value="COMPLEX PROTEIN NUCLEASE, PUTATIVE KREPB1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39671">
        <property type="entry name" value="COMPLEX PROTEIN NUCLEASE, PUTATIVE KREPB1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="259"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="888" mass="95195" checksum="F9203AA2AB5A76A0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWD4</accession>
    <name>A0A3S7WWD4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210011500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWD4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0700"/>
    <dbReference type="OrthoDB" id="266780at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="388" mass="41011" checksum="66B4086FA8FF1413" modified="2019-05-08" version="1">MTSRVPFSAASLAAYAMPEADDSTYMSTVVVPPQPHTCNAAAATVGAASSTDVTNDDYARREGFSCYPLPVSTPDSGVASDAPSALLSAPLISVSHDCHLQSPRSIDPPQSVPSLSVRESEATGVVAPAEIDHGIVADAGAEEDEAAKQDEAQTERCGANRDVQRLYMHPLAAAAAEGSFGVTSPVDPITAALSRQQQQQNRGEPCSPLSSRTLQALYAAYAEGRYSSFITQLTADDVLAPPPLALTWYPSVPAGVTRFADRKRTADSLTVTAMRQHEKSMLAEEEAHGVAEMTSTGAVPPLRRPRTEELAIPGAGPQPPSASSSVPASMGTCIPPLGIYTEECATNRSDSADAARASAAADMHANPHRKRDRDERVYEYLSHGRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXA1</accession>
    <accession>E9BFZ0</accession>
    <name>A0A3S7WXA1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MORN repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MORN repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_2070</name>
        <name evidence="4" type="ORF">LDBPK_221250</name>
        <name evidence="3" type="ORF">LdCL_220019600</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860871.1">
        <property type="nucleotide sequence ID" value="XM_003860823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXA1"/>
    <dbReference type="SMR" id="A0A3S7WXA1"/>
    <dbReference type="GeneID" id="13389594"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1800"/>
    <dbReference type="OMA" id="YEAPCAN"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP46944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="526" mass="58063" checksum="46434304345A1EAF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYA4</accession>
    <name>A0A3S7WYA4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome 60S biogenesis N-terminal, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_240011100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0730"/>
    <dbReference type="OrthoDB" id="272231at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1705"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1754"/>
            <end position="1768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1775" mass="192016" checksum="FAC03D759DA1D704" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYP3</accession>
    <name>A0A3S7WYP3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SpoU rRNA Methylase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_240029900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYP3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2990"/>
    <dbReference type="OrthoDB" id="278013at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF2">
        <property type="entry name" value="TRNA (CYTIDINE_URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="468" mass="52945" checksum="377ECC1B5101288A" modified="2019-05-08" version="1">MFLHSLKRLAYKDFDAWGYHIQWPQNQILSPLTGKVNFVVEDIKFAYNAWSLLRLAMFFGVEHPKVLSDMTKTTPSMDIMLSGNRLFFMHSRVKANLSRSKVRIALTPNHPRAFPVQELVWKTQFRFRDHHSAGVELVLGMENGLSQEVADACNLCTYIPQYGSVGSLSMLSALAIAAHSTWRAAVREEGNTSDTSLAPHRALHGHMPLSNSPNRQRDSLPHEMDLLACSNAAIKDLLEERRRAYDLQVSVLIYNELGDRNIGAVIRNANVFNCEYVAIGNRRRFNRRGALGTHKVMNVLFFETVNDDAARQLFEGYEVWLLYPYYPNLVMYEAERKGDASNCSSTFVRHEDPVLQAWGATQHELTSEHPLVVRYPHLCQKAVFLDDDLSLASCVQDVKRRKLRGILLAVPEEGCSPHPSLCKLSHRVVHVISPSFLPHQTQRGLNPALSTAIALERLRCAVDTLCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZC1</accession>
    <accession>E9BHX3</accession>
    <name>A0A3S7WZC1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat/TPR repeat, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide_repeat/TPR_repeat_putative/Pfam:PF13181/Pfam:PF07719/Pfam:PF13414/Pfam:PF00515</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_26235</name>
        <name evidence="8" type="ORF">CGC21_9075</name>
        <name evidence="7" type="ORF">LDBPK_252190</name>
        <name evidence="5" type="ORF">LdCL_250027700</name>
        <name evidence="6" type="ORF">LDHU3_25.2660</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861549.1">
        <property type="nucleotide sequence ID" value="XM_003861501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZC1"/>
    <dbReference type="GeneID" id="13388795"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2660"/>
    <dbReference type="OMA" id="SAYSYCN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5430796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP40817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="334" mass="36586" checksum="1CD2E6DB48E36340" modified="2019-05-08" version="1">MSDEAEFKRAGALFSAGKYHEAISVYSVIEALDGATAEVRARALNNISACYAALKNYEMSSKVAREVISLQPGNAKAHGRVAAAEEGLKRYSEASFYYSVASRLDANNSTYVDGAQRCHALVQAGRGVASAEAKDAYYYEKSLERAMEAMQKTSYLEAIRHFGKALDLFPSTGTSREKATLLSNRSAAYFRAERIEESADDALEAIKADDTYARGFYRLGAAKAKLKKVGDAYDALTKCVKLDPKHVDAARLLAEVLPAALESRKTAEERARDHTRQVAHMTERLSEMQAAASSNAVPHATAHGSAYSYCNFCNETGHSRSECPLLRRKRSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X035</accession>
    <accession>E9BIL1</accession>
    <name>A0A3S7X035_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methyltransferase_domain_containing_protein_putat ive/Pfam:PF13489/Pfam:PF13649/Pfam:PF08242/Pfam:PF12847</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_5450</name>
        <name evidence="5" type="ORF">CGC21_32300</name>
        <name evidence="4" type="ORF">LDBPK_262000</name>
        <name evidence="2" type="ORF">LdCL_260025600</name>
        <name evidence="3" type="ORF">LDHU3_26.2630</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861785.1">
        <property type="nucleotide sequence ID" value="XM_003861737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X035"/>
    <dbReference type="GeneID" id="13389032"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260025600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2630"/>
    <dbReference type="OMA" id="SWWEDAT"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000934">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45445">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45445:SF2">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="349" mass="39403" checksum="71BF60386A24EBE0" modified="2019-05-08" version="1">MQQLQARLSDKLDELTKDWTAEQRKLYGAVALTAVVASGAALIGANVMQRCCGGRCRAGNDATRSESHSKSSDIYESEAAARQYMEFHYTPSRESYTQRLRSVSEAYDFPTRVAHKFRTYVQPGKRKLRGLDIGCATGASVLEMSKVFDGGVIGIDFSEVFIHLAKEVVNQPTSGKKVTYTAPVQGEITEKRELELPRAVRPERCEFYAGDAMNMFEEDSKITTTTSRLYPDVKYWQAKKGETFDGVLCLNLIDRVPDPQRLLNSVVRLLAKDGILILADPYSWWEDATEKSRWLGGRKDDGVRSEDAVKAALEGKLELLNESDEAFLIRDHIRHYQLGFSHCTVWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1Q2</accession>
    <name>A0A3S7X1Q2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin family/Cullin protein neddylation domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_280027700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1Q2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3070"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="408"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="766" mass="86953" checksum="06CD5C3B5FE32C12" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2C6</accession>
    <accession>E9BKT2</accession>
    <name>A0A3S7X2C6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent Clp protease subunit, heat shock protein 100 (HSP100), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Heat shock protein 100 kDa</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Heat_shock_protein_100_kDa/GeneDB:LmjF.29.1270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_291360</name>
        <name evidence="10" type="ORF">LdCL_290018700</name>
        <name evidence="11" type="ORF">LDHU3_29.1850</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862553.1">
        <property type="nucleotide sequence ID" value="XM_003862505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2C6"/>
    <dbReference type="SMR" id="A0A3S7X2C6"/>
    <dbReference type="GeneID" id="13387291"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1850"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="411"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5431845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="867" mass="96957" checksum="B6F307D9E678283D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2G4</accession>
    <name>A0A3S7X2G4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290017800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1750"/>
    <dbReference type="OrthoDB" id="267579at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2110"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2255"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2282"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2324"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2377"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2112"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2175"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2261"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2307"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2326"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2398"/>
            <end position="2414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2458" mass="252163" checksum="F6EF39F74E1E32F9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2S4</accession>
    <name>A0A3S7X2S4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Poly(A) polymerase, putative</fullName>
            <ecNumber evidence="1">2.7.7.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_290033200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.19" evidence="1"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2S4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3990"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29411" checksum="A106A78E162F3BE4" modified="2019-05-08" version="1">MERAAEVTLIKDAFPHFNFAADAAASTALRRATDAFSMENTDEVVRLVRQLLEKLLQAEPSAAAAWTQVYVFGSSGLDAAITGSDIDLYGEPLPSSHRFFPVALNFFPSPLPPSPRPPVLPALSSPLFPSSLASLLGHDRGQRARQRSCRCVGENRRERERARRESSCRSCVYSSICRLFISPALLTPLRLPSPPPTFLSRALRMLVHAPCVRMVMITWSATFFHIMLTNIATPPFFLTCLPTLPTVCISSYTPPMLHIHGAVILPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2T5</accession>
    <name>A0A3S7X2T5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_290034200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2T5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4130"/>
    <dbReference type="OrthoDB" id="245090at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="992" mass="108529" checksum="E285310958F70D2D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2U0</accession>
    <accession>E9BL83</accession>
    <name>A0A3S7X2U0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_292860</name>
        <name evidence="1" type="ORF">LdCL_290034700</name>
        <name evidence="2" type="ORF">LDHU3_29.4180</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5432003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ36011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862704.1">
        <property type="nucleotide sequence ID" value="XM_003862656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2U0"/>
    <dbReference type="GeneID" id="13385407"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4180"/>
    <dbReference type="OMA" id="YVCVGQM"/>
    <dbReference type="OrthoDB" id="275928at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8475" checksum="DD2B842132526ABB" modified="2019-05-08" version="1">MMKLLSVLKHRARARLELARARMQLRNVCDYEVIGRFCGLLLFPFTVYVCVGQTQGYSESQIRDRIASRKDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2X7</accession>
    <name>A0A3S7X2X7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 7">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300006400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 7"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2X7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0240"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000163">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF1">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="112"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="536" mass="60455" checksum="D01B0FB30738AEB3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X362</accession>
    <accession>E9BLG0</accession>
    <name>A0A3S7X362_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_35135</name>
        <name evidence="2" type="ORF">LDBPK_300660</name>
        <name evidence="1" type="ORF">LdCL_300011700</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862780.1">
        <property type="nucleotide sequence ID" value="XM_003862732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X362"/>
    <dbReference type="GeneID" id="13385487"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0850"/>
    <dbReference type="OMA" id="MKLHLAH"/>
    <dbReference type="OrthoDB" id="275766at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP45636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="198" mass="22682" checksum="F3551AA7A144E8F3" modified="2019-05-08" version="1">MLRVCSVWCSNALHNSTPFVDGALQLMKLHLAHRNATADKNKVACHAIEQEFFREVEVFRPCFTMSASLEVAQQYSRRLYAALKYFRMDDDPLIRQLDLLLGRRAMQDGRHEGQRGFFKGARTSNTSAFGKGGEITHETLAEHAETTLPTELPHAPKVDLTAPRRPGALRINQRYRGHWVLQEPDIAITRSERREDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3P8</accession>
    <accession>E9BLZ4</accession>
    <name>A0A3S7X3P8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_6565</name>
        <name evidence="6" type="ORF">CGC21_35990</name>
        <name evidence="4" type="ORF">LDBPK_302510</name>
        <name evidence="2" type="ORF">LdCL_300030800</name>
        <name evidence="3" type="ORF">LDHU3_30.3380</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862962.1">
        <property type="nucleotide sequence ID" value="XM_003862914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3P8"/>
    <dbReference type="GeneID" id="13385671"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3380"/>
    <dbReference type="OMA" id="KCFFAFG"/>
    <dbReference type="OrthoDB" id="275643at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="202" mass="22578" checksum="A7A4C50FE296C6CB" modified="2019-05-08" version="1">MSYIPYPSAASRCTTTQTSGDARGDAFGEYATYRRVIRTVLCGVLFATPLCAAAPMSPLLKLSQTQENKKSIIPRMMSDFFYVNFLASTAAYWVLVEPFIPNPRAKEGFVPYLGPVTAEIPAVSCLFVSHLFYPGLWAIVNEPTWKLRRREFVRLNAKCFVAFGPVHVPAAVGLGMAVGVVLYPFKYMKLRAQRRDERQHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4R1</accession>
    <accession>E9BMY1</accession>
    <name>A0A3S7X4R1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL/TRIO domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">CRAL/TRIO domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_11215</name>
        <name evidence="5" type="ORF">LDBPK_312100</name>
        <name evidence="4" type="ORF">LdCL_310029000</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863298.1">
        <property type="nucleotide sequence ID" value="XM_003863250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4R1"/>
    <dbReference type="GeneID" id="13389472"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3790"/>
    <dbReference type="OMA" id="KSWFTAK"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="142"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="371"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="491" mass="55138" checksum="5F7414442304071B" modified="2019-05-08" version="1">MVAKESTAKGGSRYPPLTADQEKEVTELIELMRKRYDPLPRQLLALQRYNSPMEGTASDGAAVGTFFSPIRNYCYYFLISREWDRQKSFEMMQLSVSYREKNELDSRAELPSAICCRGWDQEKVLIALDKPTRPTNQRLDRLSAGIEQYFTFGLHYWDKHGQPVVYLNLGSVDEPGLLKKLKQLANIGQTPNLVMWELVQHLIGVQEQLLFYQQMQYAAGALKAEADDGLIRSATIVIDLNGLTYKMLWKPALDLFMNTLQTLFQYYPKCVHQILLVNSPPMVMFAYKIVRGALPHGVQRKVCIVNVADTPATMQNFIDAQYVPDYLGGLCHCEGGCVRGYDPHQKGTMKESGTAKSDTSNVQSGGQDDEAGVVTEDITLKAGQELKRAFSLKKAESVLWEFVSANGHDVAFTTYFVPKKAAQSMDTSKLPTSMLEPYVVSKASPSEGSDKYTASDDGLFVIVWDNKKSWFTAKHLQLNVFKQTATFTNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6B5</accession>
    <accession>E9BPT3</accession>
    <name>A0A3S7X6B5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_38595</name>
        <name evidence="3" type="ORF">LDBPK_330040</name>
        <name evidence="2" type="ORF">LdCL_330005300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863828.1">
        <property type="nucleotide sequence ID" value="XM_003863780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6B5"/>
    <dbReference type="GeneID" id="13391593"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0050"/>
    <dbReference type="OMA" id="VPFDTNG"/>
    <dbReference type="OrthoDB" id="276577at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="55876" checksum="D20B439AD06283C7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6D8</accession>
    <name>A0A3S7X6D8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330006800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6D8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0210"/>
    <dbReference type="OrthoDB" id="271807at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019234348" evidence="2">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12459" checksum="2C3AC60AF6E15D59" modified="2019-05-08" version="1">MHFTTEHIVSLLLFHVAYLQLVPQPVTGEDATVLGSVFWFATVYAMLQHYTTFFLEDCRSPVRLLAALCALPSFKSDSDARSGPHSRPLFLGEPRPLRSRLVSGVAGQQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6I2</accession>
    <accession>E9BQ31</accession>
    <name>A0A3S7X6I2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_331020</name>
        <name evidence="2" type="ORF">LdCL_330016300</name>
        <name evidence="3" type="ORF">LDHU3_33.1580</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863926.1">
        <property type="nucleotide sequence ID" value="XM_003863878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6I2"/>
    <dbReference type="GeneID" id="13392323"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1580"/>
    <dbReference type="OMA" id="ECGAVFF"/>
    <dbReference type="OrthoDB" id="264008at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="594" mass="66029" checksum="7E618CF13E768A64" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X876</accession>
    <name>A0A3S7X876_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340037900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X876"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5030"/>
    <dbReference type="OrthoDB" id="246382at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="434" mass="48780" checksum="E4A38FF7C4E4D588" modified="2019-05-08" version="1">METPAVYCVSDAAASLTMADDWIRGLSRQRHKAMCEAGAVFPVARTGERTEDDEAQTASSYRDSIARVPTNRLHLHMMHRRRLYKQYAMDLSVRADTHSFYQLMMWCHDHHVFLHPTVEMTRHRSAFREHVFRVKEDVDAFTPLLAIPEDLIIGFKDANTESSDPSASTDDRNNLYDAKREAEFHKLNTGENSDADICQFFFASLGMIVSDLITAKSSPLTDPRHLFAKLLSKVPTLQNAPYFDEEVVFDSNETCLADVLLQMIRNYISGGPLVNKVPLHELRWAVSVSLSHSTPLSIGAVRSIGIVPVVHLFPHGGTATNAYVVARTSREKSAEKMATFFREKFGYDFQGQANGKWIYVVPERPLKAGEAINLQAMAPVCEKDSEAEQMWRLSCGTVPESYMLSAQASARQEAATRFIVEQGEALWKASKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8S2</accession>
    <name>A0A3S7X8S2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350010300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8S2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350010300"/>
    <dbReference type="OrthoDB" id="10693188at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="643" mass="71113" checksum="C8360C8F4A600D8A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAC8</accession>
    <accession>E9BT47</accession>
    <name>A0A3S7XAC8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ribosome-interacting GTPase 2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">TGS domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_8080</name>
        <name evidence="6" type="ORF">LDBPK_355280</name>
        <name evidence="5" type="ORF">LdCL_350058600</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865105.1">
        <property type="nucleotide sequence ID" value="XM_003865057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAC8"/>
    <dbReference type="GeneID" id="13387983"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350058600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7040"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="294"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="374" mass="42104" checksum="4993BCC26EC21F25" modified="2019-05-08" version="1">MGLLERRKAIEEEIARTQKNKKTEYHVGRLKGQLARIKTEMMENAARAAGAKGGDGFDVRKSGDVRCALVGFPSVGKSSFLSRVTQTESEAAGYEFTTLTCIPGKLMHKGTEIQILDLPGIIEGAAEGKGRGRQVIATARTADMIILMLDAAKAEAQRSKIESELESVGIRLNQRFPNVTFKKKASCSMNVVSYSSTVPQTRGVSEQMVKEVLKDYGIFNADVALREDITVDQFIDVIEGNRKYMPCLYVYNKIDTITMEEMDRLSRLPHSVVLSLHWDLNVDEVIDEVWEHLNIIRIYTKKHGEHPDFGKPFIVKRDASVEHICKRIHKDIASRFKYALVWGTSAKHQPQRVGISHELEDEDVLQIMLRTANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAP2</accession>
    <name>A0A3S7XAP2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase A, putative</fullName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360022900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAP2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2300"/>
    <dbReference type="OrthoDB" id="440619at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050343">
        <property type="entry name" value="RsuA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47683:SF3">
        <property type="entry name" value="RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="5">
        <location>
            <begin position="515"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="794"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="877" mass="96419" checksum="828AE7AC3041307E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBS7</accession>
    <name>A0A3S7XBS7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360062600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBS7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360062600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7360"/>
    <dbReference type="OrthoDB" id="243443at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
        <property type="entry name" value="PTX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="776"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1116" mass="119830" checksum="5CB2DE1576D931CF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC13</accession>
    <name>A0A3S7XC13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclease-related domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360066000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360066000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7760"/>
    <dbReference type="OrthoDB" id="242653at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35287">
        <property type="entry name" value="SI:ZFOS-911D5.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35287:SF1">
        <property type="entry name" value="SI:ZFOS-911D5.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018991357" evidence="2">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="3">
        <location>
            <begin position="143"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="518" mass="58511" checksum="3D66FD14923AE064" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJB4</accession>
    <accession>E9B7C5</accession>
    <name>A0A451EJB4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA-editing ligase 1, mitochondrial</fullName>
            <ecNumber evidence="2">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_010610</name>
        <name evidence="16" type="ORF">LdCL_010011100</name>
        <name evidence="17" type="ORF">LDHU3_01.0690</name>
    </gene>
    <organism evidence="16 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Essential for RNA editing. RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the RNA editing complex (editosome), a 1600 kDa complex composed of at least 20 proteins. Interacts with terminal uridylyltransferase MEAT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the RNA ligase 2 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812621">
        <property type="protein sequence ID" value="CAC5426935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857874.1">
        <property type="nucleotide sequence ID" value="XM_003857826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJB4"/>
    <dbReference type="SMR" id="A0A451EJB4"/>
    <dbReference type="GeneID" id="13389782"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0690"/>
    <dbReference type="OMA" id="AQEWVAC"/>
    <dbReference type="OrthoDB" id="6142248at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020023">
        <property type="term" value="C:kinetoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031019">
        <property type="term" value="C:mitochondrial mRNA editing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000019">
        <property type="entry name" value="Mitochondrial RNA ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1810:FF:000001">
        <property type="entry name" value="RNA-editing ligase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1810">
        <property type="entry name" value="RNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012647">
        <property type="entry name" value="RNA_lig_RNL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02307">
        <property type="entry name" value="RNA_lig_RNL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA ligase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU75572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAC5426935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="424" mass="47239" checksum="D36923D672463204" modified="2019-05-08" version="1">MPLPQNQEDFSAYAEIDLPTETRIDAIRRTGIASQEWVACEKVHGTNFAIYLINESEVRFAKRSGIMDPSENFFGYHLLIDDFTAQVRALCALLKRKYGVTGRMGRVVLHGELFGAKYKHPLVPKSTKWCTLPNKKRIPISGVEIQSEPFPQYSPELHYFAFDVKYSVSGAEEDVVLLPFDDFTEVCSQVPNLLYAKPLVRGTLDECLAFDVENFITPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVESSGVSTIIKLRCSSFMELKHPGKQQELKATFLDTVRAGALQRVRKGKKVTVLADSMLPKLEAAANALLLNNVSEGRLSNVLSKIGREPLLTGEVKQEDVVLMLAQDALKDFLKETDPVVLNTSLSFRKTLIRSVYFAAEELLQGEWKRVMDRLKASQTEIDAAIAAQEKAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-12-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>D0VWV0</accession>
    <accession>E9BAY0</accession>
    <name>D0VWV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isochorismatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative mar1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribonuclease mar1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ribonuclease_mar1/GeneDB:LmjF.12.0060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_23995</name>
        <name evidence="6" type="ORF">CGC21_10020</name>
        <name evidence="5" type="ORF">LDBPK_120060</name>
        <name evidence="3" type="ORF">LdCL_120005600</name>
        <name evidence="4" type="ORF">LDHU3_12.0090</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13" key="1">
        <citation type="journal article" date="2005" name="Protein Sci." volume="14" first="2887" last="2894">
            <title>Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.</title>
            <authorList>
                <person name="Caruthers J."/>
                <person name="Zucker F."/>
                <person name="Worthey E."/>
                <person name="Myler P.J."/>
                <person name="Buckner F."/>
                <person name="Van Voorhuis W."/>
                <person name="Mehlin C."/>
                <person name="Boni E."/>
                <person name="Feist T."/>
                <person name="Luft J."/>
                <person name="Gulde S."/>
                <person name="Lauricella A."/>
                <person name="Kaluzhniy O."/>
                <person name="Anderson L."/>
                <person name="Le Trong I."/>
                <person name="Holmes M.A."/>
                <person name="Earnest T."/>
                <person name="Soltis M."/>
                <person name="Hodgson K.O."/>
                <person name="Hol W.G."/>
                <person name="Merritt E.A."/>
            </authorList>
            <dbReference type="PubMed" id="16199669"/>
            <dbReference type="DOI" id="10.1110/ps.051783005"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS)</scope>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 10" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812632">
        <property type="protein sequence ID" value="CAC5428246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000044">
        <property type="protein sequence ID" value="TPP43151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000031">
        <property type="protein sequence ID" value="TPP44276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859117.1">
        <property type="nucleotide sequence ID" value="XM_003859069.1"/>
    </dbReference>
    <dbReference type="PDB" id="1X9G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.41 A"/>
        <property type="chains" value="A=1-192"/>
    </dbReference>
    <dbReference type="PDBsum" id="1X9G"/>
    <dbReference type="AlphaFoldDB" id="D0VWV0"/>
    <dbReference type="SMR" id="D0VWV0"/>
    <dbReference type="GeneID" id="13390425"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0090"/>
    <dbReference type="OMA" id="VFNNEAN"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="PDB" id="1X9G"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="1X9G"/>
        </source>
    </evidence>
    <sequence length="192" mass="21640" checksum="597F2A45CF7BF04F" modified="2009-12-15" version="1">MSRLMPHYSKGKTAFLCVDLQEAFSKRIENFANCVFVANRLARLHEVVPENTKYIVTEHYPKGLGRIVPEITLPKTAHLIEKTRFSCVVPQVEELLEDVDNAVVFGIEGHACILQTVADLLDMNKRVFLPKDGLGSQKKTDFKAAIKLMSSWGPNCEITTSESILLQMTKDAMDPNFKRISKLLKEEPPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-08-10" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>D7RTH9</accession>
    <accession>E9BBP9</accession>
    <name>D7RTH9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 8">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HAT1</name>
        <name evidence="14" type="ORF">CGC21_4475</name>
        <name evidence="13" type="ORF">LDBPK_140140</name>
        <name evidence="12" type="ORF">LdCL_140006300</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2011" name="FEBS Lett." volume="585" first="2635" last="2639">
            <title>Identification of substrates of an S-phase cell cycle kinase from Leishmania donovani.</title>
            <authorList>
                <person name="Maity A.K."/>
                <person name="Goswami A."/>
                <person name="Saha P."/>
            </authorList>
            <dbReference type="PubMed" id="21708149"/>
            <dbReference type="DOI" id="10.1016/j.febslet.2011.06.017"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MHOM/IN/83/AG83</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 8"/>
    <dbReference type="EMBL" id="HM120719">
        <property type="protein sequence ID" value="ADI55327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859386.1">
        <property type="nucleotide sequence ID" value="XM_003859338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D7RTH9"/>
    <dbReference type="SMR" id="D7RTH9"/>
    <dbReference type="IntAct" id="D7RTH9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="D7RTH9"/>
    <dbReference type="GeneID" id="13391383"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0180"/>
    <dbReference type="OMA" id="FKYMAEG"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000779">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000175">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="10">
        <location>
            <begin position="145"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ADI55327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP46196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="525" mass="57950" checksum="108BCD2BA76C724A" modified="2010-08-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7P1</accession>
    <accession>A0A451EJM8</accession>
    <name>E9B7P1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_030230</name>
        <name evidence="2" type="ORF">LdCL_030007300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857989.1">
        <property type="nucleotide sequence ID" value="XM_003857941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7P1"/>
    <dbReference type="GeneID" id="13390363"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0240"/>
    <dbReference type="OMA" id="NRQIDDP"/>
    <dbReference type="OrthoDB" id="271441at2759"/>
    <dbReference type="PhylomeDB" id="E9B7P1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17274" checksum="F2FE9ACC88D71567" modified="2011-04-05" version="1">MLRRTARRAMGNSRFSGSKERDRIEQERRRRRVYDAAGNLQLGGLLLMMYDDFKKPAAIGLGMVAFLYGYSRLVVHLSREEEAEGLRLDAQSEAVARQTGKLKADRYLVKPNRQIDDPDFLNIPAFGGRGVSSSKLLSDDSVSGGALHSERKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8Z8</accession>
    <accession>A0A3S5H5V5</accession>
    <name>E9B8Z8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isy1-like splicing family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_070020</name>
        <name evidence="5" type="ORF">LdCL_070005100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858444.1">
        <property type="nucleotide sequence ID" value="XM_003858396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8Z8"/>
    <dbReference type="GeneID" id="13391844"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0050"/>
    <dbReference type="OMA" id="SRKYQWE"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="PhylomeDB" id="E9B8Z8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000010">
        <property type="entry name" value="Isy1 splicing protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="269" mass="31146" checksum="7BB4F3A8CFBE0992" modified="2011-04-05" version="1">MQDRLREIEGTLARTKERKNTILYKLSKRRQEEERLARLGVERLPTNPSEVNDEKVIKYVLFRLKQEIGDKTAQLRDQKLLSIDRDGEAVIRAKNDEVNKLLSRKYQWEGRLSFLAGEEIAPRSRKKIFIGCAKYLPEASVARKRQRGESMQEVEEDEVADSSEEDELVPDQPETEQPATRDHDYLESVKWLGSSAADMDLVRFEREAEARMRAKGDNIVSRTGSSALILSYCKEGKVMIPDEDHFRQQLVNDRKKVLQERLNALRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BB15</accession>
    <accession>A0A3Q8IBF6</accession>
    <name>E9BB15_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3'-nucleotidase/nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_120350</name>
        <name evidence="10" type="ORF">LdCL_120009100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859152.1">
        <property type="nucleotide sequence ID" value="XM_003859104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BB15"/>
    <dbReference type="GeneID" id="13390174"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0530"/>
    <dbReference type="OMA" id="HYIDIPF"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="PhylomeDB" id="E9BB15"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.575.10:FF:000003">
        <property type="entry name" value="Single strand-specific nuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730274" evidence="9">
        <location>
            <begin position="29"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="381" mass="40921" checksum="CAAA43763EA20F65" modified="2011-04-05" version="1">MAAFAFSAHALLAAVIAMLLLLALPTQAWWDKGHMCIAEIARRNLKPNVQSKVQACADVLNKIGPFPKSTNIVELGPWADDLKSMGLYTMSTWHFIDTIYNPQDVKVTINPVEIVNVASVIPMLISAITSPAATSDIITTSVANLIHFVGDIHMPLHSADLFSPEYPLGDLGGNKQIVIVNESAGTSMKLHAFWDSMCEGPQNNAVRPLDKDAYAELSAFVDNLVKSYSFTEEQMMMTNSTIMAAESYELAVKNVYPGISDRTVLSETYKANGKILAAGRVTLAGYRLATILNTALAGVSLDTIMNGTKHMQDEVEVTHTGDTYNYYAFSGVESGAAAGIFLSSFAIGCLLATAVVLAALYMRRGSSKDERAAAASASHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD45</accession>
    <accession>A0A3Q8IAS7</accession>
    <name>E9BD45_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_170240</name>
        <name evidence="3" type="ORF">LdCL_170007900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859878.1">
        <property type="nucleotide sequence ID" value="XM_003859830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD45"/>
    <dbReference type="GeneID" id="13393337"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0460"/>
    <dbReference type="OMA" id="MWFHHHL"/>
    <dbReference type="OrthoDB" id="264762at2759"/>
    <dbReference type="PhylomeDB" id="E9BD45"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730279" evidence="2">
        <location>
            <begin position="32"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="867" mass="94075" checksum="7AB9B7B392E300B8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHS3</accession>
    <accession>A0A3S7WZ82</accession>
    <name>E9BHS3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_251690</name>
        <name evidence="17" type="ORF">LdCL_250022600</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861499.1">
        <property type="nucleotide sequence ID" value="XM_003861451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHS3"/>
    <dbReference type="GeneID" id="13388745"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2130"/>
    <dbReference type="OMA" id="WRQLAIW"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="PhylomeDB" id="E9BHS3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU79505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="611" mass="68245" checksum="CE847590D4365219" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9BND0</accession>
    <accession>A0A3S7X576</accession>
    <name>E9BND0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_320250</name>
        <name evidence="2" type="ORF">LdCL_320007400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863444.1">
        <property type="nucleotide sequence ID" value="XM_003863396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BND0"/>
    <dbReference type="GeneID" id="13390019"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0330"/>
    <dbReference type="OMA" id="LASNERC"/>
    <dbReference type="OrthoDB" id="10022853at2759"/>
    <dbReference type="PhylomeDB" id="E9BND0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1085" mass="116201" checksum="FBA180E31FCB8444" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BND5</accession>
    <accession>A0A3Q8IFN5</accession>
    <name>E9BND5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_320300</name>
        <name evidence="3" type="ORF">LdCL_320007900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863449.1">
        <property type="nucleotide sequence ID" value="XM_003863401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BND5"/>
    <dbReference type="GeneID" id="13390024"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0380"/>
    <dbReference type="OMA" id="CKRIEFR"/>
    <dbReference type="OrthoDB" id="272001at2759"/>
    <dbReference type="PhylomeDB" id="E9BND5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="343" mass="37850" checksum="A71D8D15410D05C0" modified="2011-04-05" version="1">MRLCTRDVNAQGRLSKSPCIPLSQMEVGLLCTSGEAWPPLLPSFSREAVEAINRFVQGFICKRIEYRCGQLSAEDYEDAFLPRWVRMAEHRTVLMEDFFAQHGSRLSEETFRELFGAFEKMQSALRDARQEPGGGVEWRHDKRISFARPVAHRLIRRSRDRFSLRSVADVDEGAALSHPSPSPGPSSAADAWRDSLQPGSSSPIPGGTVVSVSSVTDIADADDVRTFVLPVEESADGDHFTGRASGVYYGDLLRSAGSSARSSDQGSRAAEAASFALAEGRDSLDNGAGIAEAVLQAYSGPVRRAKAWRRLWIRCFYHCILPAVVVVSLAAYYWDTLQLYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBE4</accession>
    <name>A0A3Q8IBE4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Guanine deaminase</fullName>
            <shortName evidence="7">Guanase</shortName>
            <ecNumber evidence="3 7">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_290014000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 7"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBE4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1240"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000070">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="68"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="454" mass="49112" checksum="892F957D32D836BD" modified="2019-04-10" version="1">MPVQAFLGTVFETPDRHTLNIIQDALVVVQDGTIEQVINPATDAATYASVLEAASAGGHLTRLQKGQYLIPGLIDLHVHAPQWPQLGMALDKSLDTWLQQYSFPLEARYKDLEFAEKSYSSLVSALLANGTTTVAYFASIHLEASLLLARICLEKGQRAVVGRVAMDLADQCPEYYRDASPKESVAQSEAFVQQVRALKGNTEGLVLPAVIPRFIPSCSDAALRGLGELAKSYGCHVQTHCSESDWEHNHVIERCGKHDALALDDFGLLTRRTVLAHCNYLSTEDMQLVKARGAAVGHCPLSNFYFSGAVFPLKKALDMGVHVGMGTDISGGPSASLFDACRYALAAGRALESGTDPCLSATERSQHSGARVSSVEAFFVATANGGISLDLKVGRIAPGYMFDVLVIDTTLPNSSLMIFEGIDTLEDVFQKIVYNAAPHNILRTYVNGRLVSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC12</accession>
    <accession>E9BFE7</accession>
    <name>A0A3Q8IC12_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_211610</name>
        <name evidence="2" type="ORF">LdCL_210021600</name>
        <name evidence="3" type="ORF">LDHU3_21.1910</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860678.1">
        <property type="nucleotide sequence ID" value="XM_003860630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC12"/>
    <dbReference type="GeneID" id="13386523"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1910"/>
    <dbReference type="OMA" id="TEDEDVW"/>
    <dbReference type="OrthoDB" id="242263at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599592" evidence="1">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="356" mass="38406" checksum="71D21B2BF4372DD2" modified="2019-04-10" version="1">MLCTLIAAVLILVVAPPGAQAAPGPSSFRCLRPFSATGTFTNVAKAHPTQNCDYFYFSVEDAKAELKCASPSAATTAVSDEMSCNVTVRMSMRRASDVVPRLQRQVGTDKDYFTHEASTDSTTASPTRVGNTRASAVPFLTEDEDVWRYAVSLKAKGDSSIHYKGFNGGNGYSLCCAALEEADCAWMTPQKGDKDLDCDEDVDVRFAPQRGRVLRGCPLPFPAPRSAGDGVFGASAGARVLLTDLDEGEGSGVFHAVITKPLHRFVEGPWEVMVQMWRRRQHMPRVGREDSLSVPADHSIEAEVLGRIMVPFTLNLTELQKQGRITQMPSMALTVEDVADVAQAAGEKAADEAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICI4</accession>
    <name>A0A3Q8ICI4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_230015600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICI4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1220"/>
    <dbReference type="OrthoDB" id="267639at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001099">
        <property type="entry name" value="Putative RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="129"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="599" mass="60411" checksum="249F73E11C054DE9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICZ1</accession>
    <accession>E9BK77</accession>
    <name>A0A3Q8ICZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_21745</name>
        <name evidence="4" type="ORF">LDBPK_280380</name>
        <name evidence="3" type="ORF">LdCL_280008800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862138.1">
        <property type="nucleotide sequence ID" value="XM_003862090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICZ1"/>
    <dbReference type="GeneID" id="13386875"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0500"/>
    <dbReference type="OMA" id="ESSQWHR"/>
    <dbReference type="OrthoDB" id="272879at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="929" mass="106039" checksum="72B625C2AF51F357" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID01</accession>
    <accession>E9BDM4</accession>
    <name>A0A3Q8ID01_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2 superfamily, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">PAP2_superfamily_putative/Pfam:PF01569</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_180430</name>
        <name evidence="9" type="ORF">LdCL_180009200</name>
        <name evidence="10" type="ORF">LDHU3_18.0530</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860057.1">
        <property type="nucleotide sequence ID" value="XM_003860009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID01"/>
    <dbReference type="GeneID" id="13393410"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0530"/>
    <dbReference type="OMA" id="PDYLMII"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5429257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40346" checksum="38DEBD71874DAB35" modified="2019-04-10" version="1">MGTATPATTTETMMILKRPPHHFYLWRVPDYLAIVIIAVVAAVVGTKAQPHCRDVDWSDPAIGHPFATKEVFPTYSLVIASFVVMIYFAGELLTRWSRPAGKLNMWLHVNGWVLTQTWSITLTFAVVSLSKLYAGRLRPDFLSRLASEGITETSWATMTHDSQCRAAREGRLSFPSGHSSTAFSGYVPPCMYLMGLFRTLRGGRLWLVTLLLLPLILPITIAISRTTDYRHNFDDILAGSICGSALGVLSVVISFRPSMRGEWTLYDHPDDNVETQALLMRPVTEGGEAVNESESMAAGYDSPSPPLRAHSSLCCDRRELTGIAAPSPRNKHASGASALSDDEAHSCRSFASGVQPSEVNVPPLTSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID92</accession>
    <name>A0A3Q8ID92_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_320031300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID92"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3210"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000661">
        <property type="entry name" value="NOL1/NOP2/sun family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44700" checksum="80D6CD2215D2322A" modified="2019-04-10" version="1">MPPLRGTGRGRNKAGTVPTAHTKGGFKAKGSAKPRTFDEYYSEIYGKRWPTLRAAMIEAPRKVALWNRFSQVPFEEATRGLSRVEPNSLIQAFQPARKVNSTEAASTTDRGISADDEARLQEKALAAAAGDLLHPNGVIDKPPIDAFGIKAYYLLDYASAHVVEQLQVGAFDTVLDMCAAPGGKSVAVAQFLSPDGALTCNEARADRCARLRRNLQEHVPVNYVPWRTTQRDAQTWYDPGAFSRVLVDAPCSSERHLLQQSGGSPLSLREWSEETTAQLAALQRMLLQRAIETCRVGGRIVYSTCSISPLENDGVVSEVLQRTRCEVKVIKTSSAAAAALVAPPKTATDASESDASGAEACAPHTPTVLGEATAYGRLLLPDTCHGWGPMFFCVLEKTAEHKDVPSSSSEDDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDH9</accession>
    <name>A0A3Q8IDH9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_250029000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDH9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2800"/>
    <dbReference type="OrthoDB" id="276167at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058392">
        <property type="entry name" value="DUF8079"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057419">
        <property type="entry name" value="PH-like_2_kinetoplastida"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26290">
        <property type="entry name" value="DUF8079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25405">
        <property type="entry name" value="PH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH-like" evidence="3">
        <location>
            <begin position="269"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="637" mass="71689" checksum="DBB05543D2CD69DC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDM6</accession>
    <name>A0A3Q8IDM6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G1 cyclin CycE4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330013800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDM6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1200"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000164">
        <property type="entry name" value="CYC2-like cyclin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF112">
        <property type="entry name" value="CYCLIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="881" mass="93930" checksum="700468600699378A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDR5</accession>
    <name>A0A3Q8IDR5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_280009700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDR5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0590"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018564341" description="carbonic anhydrase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="53"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="628" mass="67594" checksum="D8B3FB78C2401C3B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDV7</accession>
    <accession>E9BPG7</accession>
    <name>A0A3Q8IDV7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acid Phosphatase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_37500</name>
        <name evidence="2" type="ORF">LDBPK_332280</name>
        <name evidence="1" type="ORF">LdCL_330029800</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864053.1">
        <property type="nucleotide sequence ID" value="XM_003864005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDV7"/>
    <dbReference type="GeneID" id="13392449"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3300"/>
    <dbReference type="OMA" id="MLFFDNQ"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="201" mass="22565" checksum="4C47BECC3FEDAD33" modified="2019-04-10" version="1">MSRVTAKADGDAATLLPRVIVFDLDGTLWTPEMYQLWGGAPFKPHKQNPSIMIDKSGTEVRLIGESRDVLQTLATNPKWANTYLAISSTCDVPSWARELLGTFEFTDCAGKTVPMHSLFGDRIEIYKANKAKQHEMILRKVNRVDPSVSEYAQMLFFDNQTDNVHHVSGIGVTSYYCPSGMTKGTFEKGLEVWRRAQLSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDW4</accession>
    <name>A0A3Q8IDW4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_32070</name>
        <name evidence="2" type="ORF">LdCL_260020400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDW4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1830"/>
    <dbReference type="OrthoDB" id="267910at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP41183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="104" mass="12048" checksum="4964CD3948779351" modified="2019-04-10" version="1">MPPSGQEDQKAVSEPNPVSPSDLERMRAESNEIWRNRPRAIPRESDGAFKLAEQRVCRLPNGGVSAGVLEQLQRNRAQREAEKREKEERERKAEEQQREQNKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEU6</accession>
    <accession>E9BJM0</accession>
    <name>A0A3Q8IEU6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Haloacid dehalogenase-like hydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Haloacid dehalogenase-like hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_22205</name>
        <name evidence="8" type="ORF">LDBPK_281490</name>
        <name evidence="7" type="ORF">LdCL_280019600</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. Cof family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862248.1">
        <property type="nucleotide sequence ID" value="XM_003862200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEU6"/>
    <dbReference type="GeneID" id="13386984"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1880"/>
    <dbReference type="OMA" id="CIYNEAN"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07516">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP54282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="402" mass="44484" checksum="5AC520F0C51BDB1A" modified="2019-04-10" version="1">MTSPDSMVAASVYARRPKGVRVPAGLNPYKLVACDMDGTLLNSKHSISDYTRTVLSQLLARGVHIIFATGRPFTDVYRIKRRLNIFAATKLIPTPGLQVVTPVEPSPTSRYPSGSPNSSSHSVLPPTPSSTCSGTGANETEKIVPRCFAITSNGACIYNEANERIYERTIDPRLVQELYSMFMDDPEVNINVFRGVDEADRQQQGYTNPSDQPDDKASEEWICRYPSDLEAALYKESRFTFRVVSNLEKTFPVDRVSEIFFLCYNPEKSSVVESDISKRMKELTDELKLETSVRVAPSATYCLDIVPSDVSKASALQHVLDKLDLTMNDCIAFGDGLNDVELLSSVGKGFIMGNGNPRLKKKLPHLEVIGRNDDDAVARKLSEIFDIRVEPGDIENPLSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEZ4</accession>
    <accession>E9BRZ4</accession>
    <name>A0A3Q8IEZ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Rhodanese-like domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_6120</name>
        <name evidence="4" type="ORF">LDBPK_351180</name>
        <name evidence="3" type="ORF">LdCL_350016600</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864703.1">
        <property type="nucleotide sequence ID" value="XM_003864655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEZ4"/>
    <dbReference type="GeneID" id="13387583"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1550"/>
    <dbReference type="OMA" id="PMQEARQ"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF5">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="333"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="609" mass="65921" checksum="37EF899B0DB254E5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF58</accession>
    <accession>E9BKU0</accession>
    <name>A0A3Q8IF58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_28220</name>
        <name evidence="6" type="ORF">LDBPK_291440</name>
        <name evidence="5" type="ORF">LdCL_290019400</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862561.1">
        <property type="nucleotide sequence ID" value="XM_003862513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF58"/>
    <dbReference type="GeneID" id="13387299"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1940"/>
    <dbReference type="OMA" id="RPISIQW"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001050">
        <property type="entry name" value="Putative RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001360">
        <property type="entry name" value="Putative RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="639" mass="67825" checksum="A7C3DC924355C074" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF91</accession>
    <name>A0A3Q8IF91_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310015300</name>
        <name evidence="4" type="ORF">LDHU3_31.1470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF91"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1470"/>
    <dbReference type="OrthoDB" id="263936at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599600" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8214" checksum="F1B7259C90AF6784" modified="2019-04-10" version="1">MSAMQLLIVALAACLSVAAAKSKEEFPLVWVCLGITVVGVIAALYVAYKRPDELHLPGSVVMTAVESDPGNGKSVAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFJ3</accession>
    <accession>E9BL72</accession>
    <name>A0A3Q8IFJ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_24745</name>
        <name evidence="5" type="ORF">CGC21_28855</name>
        <name evidence="3" type="ORF">LDBPK_292750</name>
        <name evidence="1" type="ORF">LdCL_290033600</name>
        <name evidence="2" type="ORF">LDHU3_29.4060</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ36000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862693.1">
        <property type="nucleotide sequence ID" value="XM_003862645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFJ3"/>
    <dbReference type="SMR" id="A0A3Q8IFJ3"/>
    <dbReference type="GeneID" id="13385396"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4060"/>
    <dbReference type="OMA" id="HFAMEVK"/>
    <dbReference type="OrthoDB" id="276144at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="441" mass="47953" checksum="28E9E20AA4713FB6" modified="2019-04-10" version="1">MSEAARTTRHYVSDCLEERYPYDACKGFAGIRQREAGRVFNGYGPAAVDDMMNSLTDPSVPTEEKTRAVHLLYARSASQETKIEMLTKGLVPLLVATLQQCPDLLLKHQCLLLLRSLGVLAQGCFAIVREGAIPVVAGALHTVLSPAGSSEAAQACCIAAAHVLFQVSSNMSGLRWMLSLAHDSAFEGIEAAWAGEPLAPKALVSFIADSLASEATPAKATTYLIQTLARLTSLARGVEAFLAVSDAVDVMVEHLRHLPRPPTQDSELCAATLEVMWNTTLGHAGAAVMEERGVPDILFQLLVDTSGSATQVPVCVQRQLTGALSAVSQLTSVKQRSTHAVSAAEARTRIVVLLDYVREWNKLIAKQYTNASRPIPNDAAAIVTNLIQCIRLASELKPVRDVTHAIVEAMEQEDTTEAFYFRRQLYFHTRWEAEYHASVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG06</accession>
    <name>A0A3Q8IG06_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_260026600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG06"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2760"/>
    <dbReference type="OrthoDB" id="272731at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="389"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="780"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="785"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1016" mass="110129" checksum="B69ABE3338FEE0EA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG43</accession>
    <accession>E9BMP6</accession>
    <name>A0A3Q8IG43_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Cytochrome b5-like Heme/Steroid binding domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_11640</name>
        <name evidence="8" type="ORF">LDBPK_311220</name>
        <name evidence="7" type="ORF">LdCL_310018900</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863213.1">
        <property type="nucleotide sequence ID" value="XM_003863165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG43"/>
    <dbReference type="GeneID" id="13385932"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1990"/>
    <dbReference type="OMA" id="EDMNHST"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF25">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="134" mass="15540" checksum="44FD10884453F0CC" modified="2019-04-10" version="1">MSDKETYVRLFYKGTSLVVPMSFVLNEHPGGAEYILQYANQDITSAFKDMNHSTDAHALLNTFEEVEAKEGFRDIYNPAEYQLKIKLSHSYDEERRCTTEVRRWRQRTTLITVMTTLAAMGVAAYALRRHLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGE3</accession>
    <accession>E9BSH1</accession>
    <name>A0A3Q8IGE3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DENN (AEX-3) domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Denn domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_6980</name>
        <name evidence="3" type="ORF">LDBPK_353010</name>
        <name evidence="2" type="ORF">LdCL_350035000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864880.1">
        <property type="nucleotide sequence ID" value="XM_003864832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGE3"/>
    <dbReference type="GeneID" id="13387758"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3880"/>
    <dbReference type="OMA" id="HSCINCF"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="47"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="559" mass="62552" checksum="389C313E75A70E75" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGH0</accession>
    <name>A0A3Q8IGH0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein transport protein SEC13, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_320005400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGH0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0090"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001024">
        <property type="entry name" value="Protein transport protein Sec13, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF5">
        <property type="entry name" value="TRANSPORT PROTEIN SEC13, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="333" mass="36393" checksum="F5FED66982348907" modified="2019-04-10" version="1">MVPHLANGAAAPAAPQVPAIHEHTDVIHDTQFDYYGLQLATASSDRTIGIHVARAGAPLNRVATLTGHEGPVWMVSWAHPRFGNLLASASYDQKAIIWKEIHQGAPKWTPVHVIDIHQGSVNAVQWAPEEYGPVVATASSDGTVAITTYRDGCWQPSVKLSNNSNQIAHAMGATSVTFAPFKSELVDHVVVASGGCDGHVRLWVSASSPERGLGFELHQVIEAHADWVRDVAFCPTSPASRFVILASCGQDKTVVMYRKPWDQLCAEISEGASQATEWERSVIEFAEPVWRLSWAPSGEMLVVTNAKSEVFVLREGVDFTEPWIKFPLKDFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGW6</accession>
    <accession>E9BI68</accession>
    <name>A0A3Q8IGW6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ApaG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_31670</name>
        <name evidence="4" type="ORF">LDBPK_260550</name>
        <name evidence="3" type="ORF">LdCL_260011200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861643.1">
        <property type="nucleotide sequence ID" value="XM_003861595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGW6"/>
    <dbReference type="GeneID" id="13388889"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0720"/>
    <dbReference type="OMA" id="NDMCFAL"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="2">
        <location>
            <begin position="379"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="578" mass="61877" checksum="217C9CFA76C2342A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGY1</accession>
    <accession>E9BV75</accession>
    <name>A0A3Q8IGY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calphotin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Calphotin-like_protein/GeneDB:LmjF.36.6860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_367190</name>
        <name evidence="1" type="ORF">LdCL_360084500</name>
        <name evidence="2" type="ORF">LDHU3_36.9560</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865829.1">
        <property type="nucleotide sequence ID" value="XM_003865781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGY1"/>
    <dbReference type="GeneID" id="13386684"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360084500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9560"/>
    <dbReference type="OMA" id="NIWTAAY"/>
    <dbReference type="OrthoDB" id="250537at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU84125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5435307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="429" mass="45437" checksum="6B8EBB0FECA4553D" modified="2019-04-10" version="1">MSSVPSPVAPASPAVAKKVTFALSGGATEAVAPSPPAVPMLVPSVPVVLPPTAVPLVAPSVPALPSPDLPLLRATEEEPPKAVVPVDEAAPKMEHAAYQRVPDYMKWLYPALLEGSSACSPPLEFPLAEATAPHVLSSAAVLRWSEAEVLAALPTTLPPEYVVFGGARYSGASLNLVRPPLTVTRGAKRTTHLHDAMEVQRLQFLVDQLEVARHYLKIEARCVTKEQRSSSSLTTAGCAAVPTDTVSDAIHKPEGAEDVTKANIWTAAYFGSPQQLGSVMEKRKFDGILDSAGYVHYKRRQWGLKRVGDTFVLGLGSRGTPLQFAAAAGKLDSVVLLLASGARDTTFPRLKEILSADSMQVIESVFKPRSHAPRQNHAPTAEAAFTSEAALPVTTPAFTSEHVVRIDECGRSPLVQIGDATTAAMATFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH68</accession>
    <accession>E9BQH2</accession>
    <name>A0A3Q8IH68_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 12 (25kDa) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Nucleolar protein 12 (25kDa), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_25430</name>
        <name evidence="7" type="ORF">LDBPK_340180</name>
        <name evidence="6" type="ORF">LdCL_340006900</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864183.1">
        <property type="nucleotide sequence ID" value="XM_003864135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH68"/>
    <dbReference type="GeneID" id="13392592"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0280"/>
    <dbReference type="OMA" id="RRAYNNY"/>
    <dbReference type="OrthoDB" id="273406at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP39932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="319" mass="36336" checksum="D7B5F80B035EB082" modified="2019-04-10" version="1">MVKYVDTGADTAAGGNKKMRKGFKSDRLENYKRMLAKKNGKTVRDAPTCTARPKALTFDDSSRRDYLLTLHKKKNERRVQAFVDAKRKQRKDSAKTRREQREEARRAYNNYARVPILPDYTYRLPRQQDDMFADDEENEEREGEDGYSSQSAEDGEEDADMPWISIDDPEASQRRRREKRLATLPHSAHAMPGAMLGQEAGTAADTHLPVGPSSSSKLDSEYVTVDVKPLFSTSSGDAVSTRKGGAASTKTLPCNNFDDLPLVVRQELHRLRQETKGPAKTKPRMRMMKELEKIRKIRKHSRKGHGKRKASGKRKNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH72</accession>
    <name>A0A3Q8IH72_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290015700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH72"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1480"/>
    <dbReference type="OrthoDB" id="273698at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="992" mass="104583" checksum="10215878B5609FFF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHH1</accession>
    <name>A0A3Q8IHH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tuzin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340024000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHH1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2690"/>
    <dbReference type="OrthoDB" id="269715at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157:SF2">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="730" mass="79327" checksum="B32CD841C1A114CF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHI5</accession>
    <name>A0A3Q8IHI5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GIPL galf transferase, putative</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_320047400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHI5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320047400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5340"/>
    <dbReference type="OrthoDB" id="259152at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="6">
        <location>
            <begin position="281"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="661" mass="75286" checksum="6EE3E234A9DA828F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIL2</accession>
    <accession>E9BKL2</accession>
    <name>A0A3Q8IIL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BET1-like protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Qc-SNARE protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">SNARE domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC21_27850</name>
        <name evidence="13" type="ORF">LDBPK_290660</name>
        <name evidence="12" type="ORF">LdCL_290011300</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862483.1">
        <property type="nucleotide sequence ID" value="XM_003862435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIL2"/>
    <dbReference type="GeneID" id="13387222"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0930"/>
    <dbReference type="OMA" id="MRRAKKS"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000089">
        <property type="entry name" value="Golgi vesicular membrane trafficking protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP52695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="139" mass="15811" checksum="03D9EFF9251B76D0" modified="2019-04-10" version="1">MIQPQSTLFRRREGVVGDDGALTSPSSSPAPYQARPGTAAAASVHTNALQEQENDALMQALLSDMRRAKKSFTKMGDEVREQNALLERLRTSFLNTQNSLRKTMRNLDKIGWGSFTHMWVLALFVIVFFMLLYLMLRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJI2</accession>
    <accession>E9BP47</accession>
    <name>A0A3Q8IJI2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome subunit RPN7 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory non-ATP-ase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_21010</name>
        <name evidence="5" type="ORF">LDBPK_322960</name>
        <name evidence="4" type="ORF">LdCL_320035600</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863709.1">
        <property type="nucleotide sequence ID" value="XM_003863661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJI2"/>
    <dbReference type="GeneID" id="13391234"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320035600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3740"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="214"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="408" mass="46382" checksum="67FF661A96286AB4" modified="2019-04-10" version="1">MSSPPPPRNIEEDLHKNEEEKPAPELDDADIPVDPLLTLLYIRHTLTSPWSSSEERETAKAAMMEEMEKHNMAPYIRLVCEALGVPLDESKLAEMDAINAKKVAAFDARLRDAVDNLGDTEVRDVLQAKCDHYARIGDLEMCMKTNEECAAKTLATGPKLDLYFQRIRLGIAFSDNDIAAKGITDAHRLMKDGDWERRNRLRVYEGIYHVFIRDFQRGSALLLDSITTFAAGELLTFQDFVFITVVASLPVLSRPELRKRIVYSPEVNRTGVDDVRELVNSIYDCQYNKVFPNLEVVCQHLRKVVYLSPHVSYFFREMRVLVFTQFLDSYSSVTLESMGAAFGIPVPALDSMLCTLISNERIACKVDRVDGSVETYRGDTTNFDYHRIVKSGDLLLNRIQKLSRLVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJL7</accession>
    <name>A0A3Q8IJL7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal subunit protein L31, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">60S_ribosomal_subunit_protein_L31_putative/GeneDB:LmjF.35.3280/GeneDB:LmjF.35.3290</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L31e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_15065</name>
        <name evidence="12" type="ORF">CGC20_15070</name>
        <name evidence="9" type="ORF">CGC21_7135</name>
        <name evidence="10" type="ORF">CGC21_7140</name>
        <name evidence="5" type="ORF">LdCL_350038300</name>
        <name evidence="6" type="ORF">LdCL_350038400</name>
        <name evidence="7" type="ORF">LDHU3_35.4380</name>
        <name evidence="8" type="ORF">LDHU3_35.4390</name>
    </gene>
    <organism evidence="5 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 69-187</scope>
    </reference>
    <reference evidence="5 13" key="2">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="e=69-187"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJL7"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3Q8IJL7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350038400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4390"/>
    <dbReference type="OrthoDB" id="276936at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000003">
        <property type="entry name" value="60S ribosomal subunit protein L31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5434354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="188" mass="21347" checksum="7971DDAF15F56DB1" modified="2019-04-10" version="1">MTRAGMKGKVLGKEKKAAIIDARKKDAESRKNRDDKRWKRVLANMDEEKRKKFHGVGNTAKNSRVRGATRASLRKRTGRKPDAVSMEATIHLSKLLKKKTFSKRAPLAIKRIKAFVGRLMKTKDNRIDASLNTYIWHKGVKGVPGRVRVLIQRKSETTEGNKHKHFYTVISNVPVASFKGLTTKTVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJR0</accession>
    <accession>E9BUF1</accession>
    <name>A0A3Q8IJR0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14495</name>
        <name evidence="3" type="ORF">LDBPK_364430</name>
        <name evidence="2" type="ORF">LdCL_360051400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865557.1">
        <property type="nucleotide sequence ID" value="XM_003865509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJR0"/>
    <dbReference type="GeneID" id="13388443"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360051400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6000"/>
    <dbReference type="OMA" id="LMRECTF"/>
    <dbReference type="OrthoDB" id="273382at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38150">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38150:SF1">
        <property type="entry name" value="PFU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="611" mass="65592" checksum="4FD97159D0494B6F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJS4</accession>
    <name>A0A3Q8IJS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360062700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJS4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360062700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7370"/>
    <dbReference type="OrthoDB" id="276396at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="371" mass="43435" checksum="39700E42FBFA93A0" modified="2019-04-10" version="1">MWTTSMALMSKRSMKYRTKLRHRFRNPSVLPLKQTKAQRDETIRSVLQVRNINPANQSSYRYVEQRLYSTGSRLDREGVKLNTTYALQGLGDLEPLRNSKSFGFSEREALKYDSLQQAAKYEAPPVPFTPLAARKLAEGKLWPRAPEPDGMLSKEVRYLRHRANMSPSAQTFADKIAYHLRRSLKACPAHIAEQIDFAQLIIEEVIASRRSKSVYIVWATVDPAARFAMEPQLHRLNHWVQRLIMERIRTRPNIPQIAWICNGGRLERELPRELTEEMHAYASDNSSTLEMRVRYLKEMDTVNQRMRNIPWFMPYLWSKEEKAVKTRRMRKDLEEYEQRRLAAKKNQRESERDMSGRSVAPQIGAPPAYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL40</accession>
    <name>A0A3Q8IL40_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyubiquitin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360043900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A3Q8IL40"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360043900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4980"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="49"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="457"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="533"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="609"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="685"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="761"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="837"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="913"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1445"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1521"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1597"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1673"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1749"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1825"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1901"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1977"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2053"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2129"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2205"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2281"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2357"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2433"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2509"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2585"/>
            <end position="2660"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2661"/>
            <end position="2736"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2737"/>
            <end position="2812"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2813"/>
            <end position="2888"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2889"/>
            <end position="2964"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2965"/>
            <end position="3040"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3041"/>
            <end position="3116"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3117"/>
            <end position="3192"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3193"/>
            <end position="3268"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3269"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3345"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3421"/>
            <end position="3496"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3497"/>
            <end position="3572"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3573"/>
            <end position="3648"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="3649"/>
            <end position="3724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3724" mass="418061" checksum="E549E3E70DC333C8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILG4</accession>
    <accession>E9BUK6</accession>
    <name>A0A3Q8ILG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PIG-P, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">PIG-P_putative/Pfam:PF08510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_14770</name>
        <name evidence="12" type="ORF">LDBPK_364980</name>
        <name evidence="10" type="ORF">LdCL_360057000</name>
        <name evidence="11" type="ORF">LDHU3_36.6700</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865612.1">
        <property type="nucleotide sequence ID" value="XM_003865564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILG4"/>
    <dbReference type="GeneID" id="13388498"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360057000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6700"/>
    <dbReference type="OMA" id="KGICNRN"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016542">
        <property type="entry name" value="PIG-P_GPI19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008765">
        <property type="entry name" value="PIG-P_GPI19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="9">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5435077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ38935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP48604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="156" mass="17430" checksum="1A8C77413E2E330F" modified="2019-04-10" version="1">MTEDSQGAQIAINGFIGSILIVVGSITYVLWAVLPDDVLHRLHLTYYPDRYWAVAIPAILVMFLFHYFTTSWLLVLVTTHPLTDGRCITDVDSKPDKEIEVGALADSSSSVPPWVDIPVSVASHLLFEPWNEKVRYNAPGPTEMMNGENGRRGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM24</accession>
    <name>A0A3Q8IM24_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_350020000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM24"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2000"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000303">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FCP1 homology" evidence="8">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="584" mass="64757" checksum="EA382AF84588D564" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMF9</accession>
    <name>A0A3Q8IMF9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase-associated protein LEO1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350033900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMF9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3740"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="554" mass="61508" checksum="F724E142BB28F2A5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPW3</accession>
    <name>A0A3Q8IPW3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclophilin 7, putative</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350041600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPW3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350041600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4800"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000072">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="247" mass="25641" checksum="6FC0AA849D71B343" modified="2019-04-10" version="1">MAVVLHTTVGDLPVLLHYQTCPLASFNFLALCASGYYDGCTFYRHFPGILLQTGDPTNTGKGGESIFAQLPFVANTADGDEGGDAVSSEAASVAAAGILPRRYFHDEGFGVTTHAQRGTLSMAHKGTRADTNASQFFITTSPQSSFDGFYTAFGVVDLNGVYSASEAAVVAEVASCPEGEVAGSSLAIAEPDAVGGAAPRCGDAVLTALEVASAKVDEKNVVQLASRARITNVTVLYNPFAEGKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H549</accession>
    <accession>E9B7S4</accession>
    <name>A0A3S5H549_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_27390</name>
        <name evidence="5" type="ORF">CGC21_30225</name>
        <name evidence="4" type="ORF">LDBPK_030560</name>
        <name evidence="2" type="ORF">LdCL_030010700</name>
        <name evidence="3" type="ORF">LDHU3_03.0590</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000043">
        <property type="protein sequence ID" value="TPP45067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000061">
        <property type="protein sequence ID" value="TPP52952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858021.1">
        <property type="nucleotide sequence ID" value="XM_003857973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H549"/>
    <dbReference type="SMR" id="A0A3S5H549"/>
    <dbReference type="GeneID" id="13390396"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0590"/>
    <dbReference type="OMA" id="GCYWLLD"/>
    <dbReference type="OrthoDB" id="272328at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="178" mass="19784" checksum="E6DE519F3F3B39FA" modified="2019-04-10" version="1">MKLLKFVNSDAPHTLVDVQLRNQRLWFPCRNGNAAVAAKSWTLNAASPTSLSGGYWLLDDDDKPICEITDVLLALPETAANAAGSSGTFAPRGVTDKDVDGIDFRSKMGRQMERERATYGATSKTATKSARTMMNAEEVTEKKHERMKREREAVAEAIEDNDASVMEPRKKERKHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F8</accession>
    <accession>E9B8A0</accession>
    <name>A0A3S5H5F8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_24540</name>
        <name evidence="7" type="ORF">CGC21_9300</name>
        <name evidence="6" type="ORF">LDBPK_050100</name>
        <name evidence="4" type="ORF">LdCL_050005900</name>
        <name evidence="5" type="ORF">LDHU3_05.0130</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858197.1">
        <property type="nucleotide sequence ID" value="XM_003858149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F8"/>
    <dbReference type="SMR" id="A0A3S5H5F8"/>
    <dbReference type="GeneID" id="13391040"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0130"/>
    <dbReference type="OMA" id="FADMAYF"/>
    <dbReference type="OrthoDB" id="256429at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000058">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF299">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="399"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5427267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="637" mass="71846" checksum="88EB76178EC8485F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5P2</accession>
    <name>A0A3S5H5P2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_060007900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5P2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0340"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="759"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="855" mass="89883" checksum="79FBF83ED621A194" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5P6</accession>
    <name>A0A3S5H5P6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-dependent steroid dehydrogenase protein, putative</fullName>
            <ecNumber evidence="6">1.1.1.170</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_060008600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.170" evidence="6"/>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5P6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0420"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="407" mass="46073" checksum="38446FF02E7744CB" modified="2019-04-10" version="1">MPPKELNPLLSPEQKRAASQSYPPVPKKCVVTGGTGFVGTRLVEMLVERGAEKVVCFDIVPKEKAIGVWDHPAIEYVVGDITSYSDVSAAIEGSDCVWHLAAAVGPFHPHDLYRRVNYGGTVNVIRACKEHGVKKMIFSSSPSTRFNGSLFHRPNVDGLTEDEMPKLPLERYMQMYAQTKAEGEMAMRESIDDDFWSIAVAPHQVYGPRDNLFLPNMLEAAGTGKLRVFGKGDNRICFTHVDNYCHGLIIAEKQLYKNSPYLGRFYIVTDADTHPEPAAYCIFWKELDKAIVRMGFGSIMKKVHYPFWFLYIAALFAELAGWVMGTTFKLNVFNVFVLTMNRWFRVDAAKRDLEFQPIIPFGDGWNDTIEWFQLNWLPKFKKQDHSSIAGISSGSQQKINIQARKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5V7</accession>
    <accession>E9B918</accession>
    <name>A0A3S5H5V7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_1490</name>
        <name evidence="6" type="ORF">CGC21_10080</name>
        <name evidence="4" type="ORF">LDBPK_070220</name>
        <name evidence="2" type="ORF">LdCL_070005700</name>
        <name evidence="3" type="ORF">LDHU3_07.0110</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000065">
        <property type="protein sequence ID" value="TPP40860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858464.1">
        <property type="nucleotide sequence ID" value="XM_003858416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5V7"/>
    <dbReference type="SMR" id="A0A3S5H5V7"/>
    <dbReference type="GeneID" id="13391787"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0110"/>
    <dbReference type="OMA" id="RMEHRKL"/>
    <dbReference type="OrthoDB" id="269892at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="192" mass="22308" checksum="65D7B998D0E9855D" modified="2019-04-10" version="1">MFRRTCTPRLLACTSALLKRSGKPGDLPDYKQVYLPYDTAPTKMELDRERRKFMHAYSGRMEHRKMVEVKDVPQNMYTYGKEGMSVPISIFKDQADPVIGPEWTYPGIFENKIVAQQWYMEELFDREKSNTFESPWQRQVLDNQVKRRLGKVAWRMSMLNIKTIDIFHKERGASKRPGAGDTKAPATPAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5X8</accession>
    <accession>E9B915</accession>
    <name>A0A3S5H5X8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_1010</name>
        <name evidence="5" type="ORF">CGC21_10250</name>
        <name evidence="3" type="ORF">LDBPK_070190</name>
        <name evidence="1" type="ORF">LdCL_070009500</name>
        <name evidence="2" type="ORF">LDHU3_07.0550</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000059">
        <property type="protein sequence ID" value="TPP45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858461.1">
        <property type="nucleotide sequence ID" value="XM_003858413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5X8"/>
    <dbReference type="SMR" id="A0A3S5H5X8"/>
    <dbReference type="GeneID" id="13391784"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0550"/>
    <dbReference type="OMA" id="LHYTYAM"/>
    <dbReference type="OrthoDB" id="270013at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="109" mass="13024" checksum="4853C8AD74CC365C" modified="2019-04-10" version="1">MRRTVRALYNSFERGWKDKTVHPLDRRGRFNLDEAAAELQLDEAYVASLYKPLHYTYSMKGQRYPAEQGRTSRPGSLAASRDRMFPLYRRNYKLDRELRVLDHRRISTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H613</accession>
    <accession>E9B9A2</accession>
    <name>A0A3S5H613_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_071190</name>
        <name evidence="1" type="ORF">LdCL_070016800</name>
        <name evidence="2" type="ORF">LDHU3_07.1410</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858547.1">
        <property type="nucleotide sequence ID" value="XM_003858499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H613"/>
    <dbReference type="GeneID" id="13391831"/>
    <dbReference type="KEGG" id="ldo:LDBPK_071190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_071190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1410"/>
    <dbReference type="OMA" id="MRCATRI"/>
    <dbReference type="OrthoDB" id="266105at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21650" checksum="91527C19AE1D63FF" modified="2019-04-10" version="1">MRCATRISRSLLNGADRGAGSPWRGTSIVRAVGAIHGLQVGTLDITGVSAGLQCTLSTSSFFSVDDGGGPAAPLLPSEPAELHAPGVVEQPGMPRKGCVYTVHVVGPAAFVAAVAEVLGDDVLVDLAGRYHVEPYAYWRSGKHQCPTVRLSYDRLRRTEDSLRILRAPDNTVARQRRLYHAIFAASQPGRWPSRHAGGRGTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H638</accession>
    <name>A0A3S5H638_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080007600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H638"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0330"/>
    <dbReference type="OrthoDB" id="267885at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="438" mass="45708" checksum="A0A7BF39726AE7B5" modified="2019-04-10" version="1">MRLTPMQSPSKASAASLTALTVSTSSERAELLSVPQSEHPIEPLGYRERPAPTASAASAASSGHPQHAGPMKVPSPQATRHHSDRCRHSRSLATATAAAGSNKSATYKPYSLSSYKTLMADVAARKSGGLGPSDTDEQRAAREKRERAKTYARHAVKVARAALAGVGSCADEGEVDPGTINISPVSSSARAARARGSSSARSSSSDASTTATTITTTSTSASRSASAEFPEHRRQPPRGTPCAAPPPHATPPQHAMLEPSSSATSPRQLSAAGVNGGEVAPSCSGAESTNAKSPKSVLPPLSAPPRTSPAVAAFAVAAAPRRQIMQARRRRERALTYAREVSQKRRRPTPADFEGDNSACAASGGAKSRTGPVVKSGDTDEDDMWLGRTAVISAPGAFRGADMPDPDRAQRLQRLLELEALHATKREAVEGIRRQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H646</accession>
    <name>A0A3S5H646_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080008800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0450"/>
    <dbReference type="OrthoDB" id="267475at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1910" mass="202140" checksum="3AF1F7D59276F7CF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6G5</accession>
    <name>A0A3S5H6G5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease 24, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_100014500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6G5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1110"/>
    <dbReference type="OrthoDB" id="276116at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="83"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="488" mass="53973" checksum="CB38A71FBC84F8CB" modified="2019-04-10" version="1">MSRLPSTASDNEPAHLTQMEDERYRKTLIEGFMSVPEVEGDEGASNGDPSCQQKDQKAQEYVEMDDDDDMTVVRLAAGELKENTNIYKSAFHVFKANVGTGVFLLPTFYPDAGYVVSVILGVLIGAAVVDCTRLLMDVKIKINRSDVTTYSQVCRYVCGAGLGWFLFVAMCLAQFGFCLMYTQLFGDTMVELANFKGSKYLWVSVVFFLCFPMTCFSDNLSLLAIASIIATVSVFYSLICCFVMSLLQLSQDGVHPGCDVAGNRIPVGWFNNLANNMMVLEGIAIILPVHAACTQKRLVPKMATLVITGVIAWYILFGLTGYLAYGNSMTTSLVAKMAHSPWGTSVRVFFALNLVFTYPVQFMSAMQLIDQTVRCKPRSWMGIGLRLLINLVIWALAMGMPTSAVNTVVAFVGALPSVCMVMIIPSILAMHVKYAVEHPDADRNTLQYWKKIFVTAPCFTFKRIRCYVYLVVAVLIMVIGTYSIAETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H701</accession>
    <accession>E9BD54</accession>
    <name>A0A3S5H701_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_170330</name>
        <name evidence="5" type="ORF">LdCL_170008800</name>
        <name evidence="6" type="ORF">LDHU3_17.0600</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859887.1">
        <property type="nucleotide sequence ID" value="XM_003859839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H701"/>
    <dbReference type="SMR" id="A0A3S5H701"/>
    <dbReference type="GeneID" id="13393304"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0600"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000089">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18696" checksum="BADB4A90179BEF1F" modified="2019-04-10" version="1">MSYTGEESTGMPPQPPMMGPGSATADQTSIVSGGKLGGKGKGKGKGKGKRGGKTGGKAGRRDRMSRAARAELNFPVGRIHSRLKDGLYRKQRCGASAAIYCAALLEYLTTEVIELSGAAAKAQKTERIKPRHLLLAIRGDEELNQVVKATISRGGVVPNVHKALEKKSKKKSAKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H731</accession>
    <name>A0A3S5H731_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dpy-30 motif containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Dpy-30_motif_containing_protein_putative/Pfam:PF0 5186</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_180011200</name>
        <name evidence="6" type="ORF">LDHU3_18.0810</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H731"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0810"/>
    <dbReference type="OrthoDB" id="263203at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="200" mass="20555" checksum="5D9C44F40F6CBCD2" modified="2019-04-10" version="1">MFSTTAADASLEAVDAETMHAFRMHLGDVPRGAMAATTQEAPSTPAGLKGTSSSAFLSSAFSGVTAGYSKDDAGADDEIPEYALPDAQYIERTILPLLLRGLEVVAQARPPDPLAFLGAYMICNNPQKPSSKNAPASANSLEKAKPTCVSAPADDSASPALAEAVKQAMSRFSASKSNTSAASKPTTAARCAPSVDTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7Y0</accession>
    <name>A0A3S5H7Y0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340048800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340048800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6250"/>
    <dbReference type="OrthoDB" id="68437at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057466">
        <property type="entry name" value="CFAP46_TPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25439">
        <property type="entry name" value="TPR_CFAP46_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2044"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2372"/>
            <end position="2391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2599" mass="282584" checksum="2EF236595CA9F178" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNS0</accession>
    <name>A0A3S7WNS0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine-threonine protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_040012100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNS0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0870"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="169"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="391"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1242" mass="133355" checksum="0DA995462A0620A3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNX9</accession>
    <name>A0A3S7WNX9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA nucleotidyltransferase, putative</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_040017700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNX9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1460"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3090.10:FF:000016">
        <property type="entry name" value="Putative tRNA nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="523" mass="58409" checksum="3F62E99775B277F4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPF9</accession>
    <accession>E9B8R1</accession>
    <name>A0A3S7WPF9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_060510</name>
        <name evidence="2" type="ORF">LdCL_060010200</name>
        <name evidence="3" type="ORF">LDHU3_06.0610</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858357.1">
        <property type="nucleotide sequence ID" value="XM_003858309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPF9"/>
    <dbReference type="GeneID" id="13391661"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0610"/>
    <dbReference type="OMA" id="NDMCDID"/>
    <dbReference type="OrthoDB" id="275344at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="486" mass="54216" checksum="4935F59899A22A9A" modified="2019-05-08" version="1">MAAGGRKGSALAADPHHPSTPHGSAHGRHALTAFGARRGGELAFYIQQGGDLTSQGRYLVIGDGLMAPFMALCLRVHGLECDLAHHPSQNDLDRGTIVLTPSVTQLMGDVLNVSVPSGSVVGRVLTFDHVGNDMCDIDLNEFREKGESPTFFCCDRLKVESALMSLCRIGAHSCMVLPKPQIDKGGLEPLESGGVRVRFTSGLQQDYLGVICTARNQELVPELTITNEELQARAENAEKYRDTFSKSVRWMELCVPPLPELGKFEKRFTPGSQEIVEILTPRDAKMTVRPTMMATKLFYNVTLTIPDGTADPRLKSTSTKLFWDDVVMHWTSGVPGYISHTMFRPMFTHLQQNFTKSSALVYRTPLFLMPHWSEGGGRVIKVAHAAHGSCFDAVDVSDAQSFTDCFTLARTIAGGEDVAAFLKERRLQVMEEMDHHSRLTYYGLKERGQMAYMMSRFNMKIMRKYKKSWRFILQNYVTLMPKSIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ85</accession>
    <name>A0A3S7WQ85_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Atg6 BARA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_080009000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ85"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0470"/>
    <dbReference type="OrthoDB" id="263940at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="963"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1188" mass="123490" checksum="2E209552827E6EC0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSK6</accession>
    <name>A0A3S7WSK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ACR, YagE family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized_ACR_YagE_family_COG1723_putative/ Pfam:PF02582</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_130015600</name>
        <name evidence="6" type="ORF">LDHU3_13.1250</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSK6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1250"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="340"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5428477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="592" mass="65449" checksum="4E18746417408F69" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSX7</accession>
    <name>A0A3S7WSX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_4605</name>
        <name evidence="1" type="ORF">LdCL_140008900</name>
        <name evidence="2" type="ORF">LdCL_140009000</name>
        <name evidence="3" type="ORF">LdCL_140009100</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSX7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0500"/>
    <dbReference type="OrthoDB" id="260068at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="310" mass="34559" checksum="BB4DA6451C1B2A27" modified="2019-05-08" version="1">MGLLGKERAGSFKATDTSGRHFLWTIDKFSQYTLGVTLDSDNVTCFTKVKFHLHMTLRTCGAVGIYIHYKKPPIPKYSYYLTNSKCEGTRQHTAHSLPDGTERCGHWNVCSHGDLKEFLGEDDTLLVHFCFDDDTLVVNQLGQSNISVTWSIPKLETQNLCPYSSRSFFVGDTVLIAQIDAKQKDGHTGRKYSYEDVVTYIIFVFCRKGNMPPHSIELVDSAGNAYFQLSKKEDESGLTALVDRSVVEKNIENTGALLVRINFSTSGNPLDLLNTISDDVNAEGERKGSTSNGCTVHLDDKKEVCTVMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTE7</accession>
    <accession>E9BCB3</accession>
    <name>A0A3S7WTE7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_150720</name>
        <name evidence="3" type="ORF">LdCL_150012300</name>
        <name evidence="4" type="ORF">LDHU3_15.0920</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859597.1">
        <property type="nucleotide sequence ID" value="XM_003859549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTE7"/>
    <dbReference type="GeneID" id="13392938"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0920"/>
    <dbReference type="OMA" id="CMHTSQH"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000019">
        <property type="entry name" value="tRNA synthetases class II (A)/Threonyl and Alanyl tRNA synthetase second additional domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="491" mass="53452" checksum="0F2D8610158BD3D5" modified="2019-05-08" version="1">MAAVFMRVGELACQKDSFLRELTATVVSCEPAKTAVAAAKKAKGASSDTVTYDVILSDSVLFPEGGGQPCDHGTLRVVSGDNDKADPSCGATAAPPLSITNVRRVGDTCVLTSPAALPVGATVHQMVDWPRRMDHMQHHTGQHLLTAVVEREDTLRLPTVSWSLTHPYCFIQVDVGGYASDPASPYHAYITKEKKISDEMVAKIEVLCNDAIAQSTAVQCDVFENREVYMREQDRRHQTAAASADGGTEAFRSRGIPEDVTGPIRIISLDAIDSCTCCGTHLRTLAELQAMYLLHQEVKGTLVKLYFITGKRAARQFHAMYHRERQLMPELGGSRPNDFVSVVQRRSKDATDLEKLMKRWTLELASVEAQRIAAAVPASHAATVTVPLRRDDVDLEFFNEVRARLDAAGLRRVVLVSAWAAERCTAGTLASAKDVAGQVFVTGGETPADMEKAVQLVKETLEGMKGGTSKLGFRGKGSLKEWDTLVARLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUP8</accession>
    <accession>E9BDH6</accession>
    <name>A0A3S7WUP8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_37360</name>
        <name evidence="5" type="ORF">CGC21_4380</name>
        <name evidence="4" type="ORF">LDBPK_171540</name>
        <name evidence="2" type="ORF">LdCL_170021800</name>
        <name evidence="3" type="ORF">LDHU3_17.2110</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000040">
        <property type="protein sequence ID" value="TPP55027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860009.1">
        <property type="nucleotide sequence ID" value="XM_003859961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUP8"/>
    <dbReference type="SMR" id="A0A3S7WUP8"/>
    <dbReference type="GeneID" id="13393287"/>
    <dbReference type="KEGG" id="ldo:LDBPK_171540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.2110"/>
    <dbReference type="OMA" id="DMSIDHD"/>
    <dbReference type="OrthoDB" id="249637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="257" mass="30037" checksum="3CA6853A69B75658" modified="2019-05-08" version="1">MTAPESKGFAELYHQLLQDGVQLQKELEAYYLRQEGYIRKRVAVLDEMQENIADERRCLELQHQECRAQISAARKQAASFLSDERKVSQAVRHAQPFLAAQEAEIDKRLEELQREKEREDTALLNVMARQEALGKQEALLASRERQRFLEEQDLQKALIEMRSLNREMEERRKSLLRKHGTVAEWDRKLESRERELLVCQDQLRENLKALEQEENALGIHPAQRTAVAPAVSQRTVMDDHDMSIEHDSACEEIDYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUT2</accession>
    <name>A0A3S7WUT2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60S ribosomal protein L7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180007200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUT2"/>
    <dbReference type="SMR" id="A0A3S7WUT2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0270"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF40">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="298" mass="34458" checksum="CFA73DA065C3D1BB" modified="2019-05-08" version="1">MGKNPPKWLPGERVKETILLQRKSVEQLRADRVLRKDKLQERRERHKNKLDAKRKRKLSTKKFISAQTILKHAQRKENQGRKFQKIGEKVEGRRRHVNFGELKKRLRESPVRLVVRAKGSQIPPEVAAAFRKLGLLKIYSARLISLTPRTEKLIEQLTPFSIVGQPDRAQVESLLRTRGSLYNEETQTKRLISGNLLLEQALGQYNVLCIEDLVETIATHGEHVEEVLRHIAPFDFHPPRQLFIERHRSVHQKLEIVNKHSFAAYLSDQLQQITVEKQRKTAAAAKKSTTVAVKRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW13</accession>
    <name>A0A3S7WW13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200017000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW13"/>
    <dbReference type="SMR" id="A0A3S7WW13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1560"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="457"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1105" mass="119745" checksum="06A21B08DFF040CD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX91</accession>
    <accession>E9BFY5</accession>
    <name>A0A3S7WX91_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_16185</name>
        <name evidence="13" type="ORF">CGC21_2095</name>
        <name evidence="12" type="ORF">LDBPK_221200</name>
        <name evidence="10" type="ORF">LdCL_220019100</name>
        <name evidence="11" type="ORF">LDHU3_22.1730</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860866.1">
        <property type="nucleotide sequence ID" value="XM_003860818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX91"/>
    <dbReference type="GeneID" id="13389589"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1730"/>
    <dbReference type="OMA" id="ICGFVEP"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="118"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5430098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP54025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="394" mass="44136" checksum="A2A9AB2EEE29A17F" modified="2019-05-08" version="1">MLFRCCRPQSEEGEWKDIYGDPVRPRRSGYEYPLDALQISAWAAIAVLAALHFMVQIPFFDGARFAVVLVISSVLMTSVVFTKVALELYPQQDPAVFRTDLPRLNQDELVPESAEPSTEPCVFCRRFVQVGCKHCSVCDKCVPGFDHHCRWLNSCVGAKNYRLFATFMGVAWAGMAWVTALSLYTIQLMLRDVDAFKRHMHTQAYHSPIRAFPALVVFNFVCLLIAVAGIGSLGKLICFHVYLDITHQSTYEHIVKRREKKRALGEYRSQHGEPESKGSLACFELRKRRNFKRHGADHANGPDMNEEDNRDGEADSSVSPQQPTLNDASGASAVCEEGSQESSGSRAEDIRRRAAYSSAGRQQYLPVPERGEGRSDAPVSDGISYTFEPVQQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX93</accession>
    <name>A0A3S7WX93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATG12/APG12, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_220018600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX93"/>
    <dbReference type="SMR" id="A0A3S7WX93"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1650"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="198" mass="20973" checksum="5D55BAEC1B488A0C" modified="2019-05-08" version="1">MHAPPKPPPPPRTHYQYMHSFECRCLLSKKMLRLYGAGTVPVIVEPTESHLRLSPSPPSLNGDSKSSAGSAGSFGGYARNGQLSSSGRSGAGVTASSAASAFTSPSAKSTLKCILPRSKSVAEVILTLRGRLALDSCQSLFLSVGENDVLVPGNSLLGDLYERYRNPDGFLYLGYLLENTFGGDVRSAAVEASVHTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXE9</accession>
    <name>A0A3S7WXE9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_230005900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXE9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0120"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="54"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="346" mass="36957" checksum="0C26BCE221B0D204" modified="2019-05-08" version="1">MTALADEVREKYSLSLSSDYIERCVQAKTSITSLELYQKSLWENLRDICGTSLLPYGIGAQVSATLPNAVVMQINASRDATQPLRPCADVSDDEVILNAAFQRNSSKRLLRLQLTDGNVEIPALELSTLRVFQGIPTPGEKVLIHKDAEVRNGCIILSESNVSLLGGEVHQLKQDFLAHRRRLEVGYQTSNGLDGAPRFAPLEVGHHYRSSVAHSGAPADIEYQGGASPYHANERSGMRGNYSHNGCGGGRAQQVGGNYGERGSAGEHGRGGGRRGRGGRGVDGSYGGDGWRGHERGGGGYGRRGGGGGGDSRGRAGGASYHVDTANFQPLAKFPEINEANFPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXG0</accession>
    <accession>E9BG27</accession>
    <name>A0A3S7WXG0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_18550</name>
        <name evidence="4" type="ORF">CGC21_17660</name>
        <name evidence="3" type="ORF">LDBPK_230070</name>
        <name evidence="1" type="ORF">LdCL_230005600</name>
        <name evidence="2" type="ORF">LDHU3_23.0090</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860908.1">
        <property type="nucleotide sequence ID" value="XM_003860860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXG0"/>
    <dbReference type="GeneID" id="13389632"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0090"/>
    <dbReference type="OMA" id="KRRHYHA"/>
    <dbReference type="OrthoDB" id="260795at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="173" mass="19968" checksum="A3C5734739D8E9B6" modified="2019-05-08" version="1">MLRCVSRRLWYQFKDLKSKVVLEKLRNSKLQEGVHPSDIDMEELARESGIAPSSSVNVQDFMHEKEAVLEMLQDQRLRRIARREAFLEWQAGQREKGAAHRLVRQSRKAEKYKRRHYHATSGRMLPISLSPDEAPPGRRMPVSMPKACVSSTEFLRGGPAEDRHAIHLSLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYR4</accession>
    <name>A0A3S7WYR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250006900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYR4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0240"/>
    <dbReference type="OrthoDB" id="246293at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113978" checksum="2F9CE4079A78570C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYU3</accession>
    <name>A0A3S7WYU3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LdCL_240029300</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYU3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2930"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002281">
        <property type="entry name" value="DNA repair helicase rad3/xp-D, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002858">
        <property type="entry name" value="DNA repair helicase rad3/xp-D, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU79322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="813" mass="91880" checksum="EB108AECA7C64171" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X123</accession>
    <accession>E9BJH1</accession>
    <name>A0A3S7X123_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Protein_kinase_putative/GeneDB:LmjF.27.2460</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_32120</name>
        <name evidence="11" type="ORF">CGC21_18570</name>
        <name evidence="9" type="ORF">LDBPK_272410</name>
        <name evidence="7" type="ORF">LdCL_270032500</name>
        <name evidence="8" type="ORF">LDHU3_27.3640</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000015">
        <property type="protein sequence ID" value="TPP53946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862092.1">
        <property type="nucleotide sequence ID" value="XM_003862044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X123"/>
    <dbReference type="GeneID" id="13386827"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270032500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3640"/>
    <dbReference type="OMA" id="QRYSHAG"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001638">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5431372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP45941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="299" mass="32193" checksum="5CB24B8C67A2E30B" modified="2019-05-08" version="1">MSLDADYEVESYAFVAGCRVKVYRCTHRSTGAKRAVKVYHTAAMDSRRAAMAVEEGTLAKSLPAAPQLVRVFDVYVEVERVSIVMEYMEHGSLYQRITTCGPLAETEARDVARHILTGLALLHANNVMHRDIKPENVLVRTTTGSSTGLGGAAAKTASAATTVVAIGDFGFATRRIPHDEFVGSPQYSAPELALVALQQRYGHAGAALPITTRPLYSEKCDIWSAGVVVFVALTGLLPFDGATPEDVFTAVIRNAVPFNRVPPGRMGPSARAFVDALLTPNPSKRPSAKEALRHAWLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1W1</accession>
    <accession>E9BJY7</accession>
    <name>A0A3S7X1W1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_22750</name>
        <name evidence="5" type="ORF">LDBPK_282670</name>
        <name evidence="4" type="ORF">LdCL_280031800</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862365.1">
        <property type="nucleotide sequence ID" value="XM_003862317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1W1"/>
    <dbReference type="GeneID" id="13387101"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3600"/>
    <dbReference type="OMA" id="CCTSAVC"/>
    <dbReference type="OrthoDB" id="266273at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600672" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31387" checksum="659B0ED132FB31C3" modified="2019-05-08" version="1">MTRHSKSVRAASAGVVLAMIVMAALCCTSAVCAPATARTSFENGRRFAAIPEMPAVVKQIWSVPPNSAAGAGRPSHVMVNAPPKYEWADQEYPPNSASQTELTLALAAERVHKDADHVRASSPGVVAMNTAAIAPADQPHIMPAALPAQLLRSPLANGEAAPSLEQLSKVLSLLPSHQRKQLVQPSYRAAGQLAVEQDGQKIAVEVAPAALTAYAGSSGSSEGSTSREDNRGAILSSGVIASFTVALTFAGLLLILVLAEACAMASAFMEDRRMRATRDAKGADNPVEPKNGDFRDTAVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1Y7</accession>
    <accession>E9BK28</accession>
    <name>A0A3S7X1Y7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_22960</name>
        <name evidence="3" type="ORF">LDBPK_283120</name>
        <name evidence="2" type="ORF">LdCL_280036500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862406.1">
        <property type="nucleotide sequence ID" value="XM_003862358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1Y7"/>
    <dbReference type="GeneID" id="13387142"/>
    <dbReference type="KEGG" id="ldo:LDBPK_283120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.4130"/>
    <dbReference type="OMA" id="CTHGPRR"/>
    <dbReference type="OrthoDB" id="272860at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="385" mass="42833" checksum="71595E6E288D86F0" modified="2019-05-08" version="1">MSIVVNTTSAKPPPREGESASSAESLVALMQQAYTQQYTEARNQYKASHARFTARLKRPPLSQLERYCTNVFRDLSFYTSAINAEETCAPSVCTHGPRRIGIHSVNHELRLRAQKRLRAAPAKPKRDADDVLTLLVAQEAAEYADLLELEAKFFMGVARAYYQTIFGPTDDLVWLEAQARRSFEDEYNRATMAFLAQLREEIWGAEQRLLLRALGMFPDALPHVGQLRLIAAERDALQQAKLSVLESREAAPLWQRVCAIRGETESEEDIIFRRILLACVVEAHGISEGYLRYDTVTGRLRHTYKEVPPFMRDVIDYSMQFEPFAAVLEEETQRMRIAEEAEGACASLAAALASGADAEGNVSSTPDAATAPIAPSHADQPAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2X3</accession>
    <name>A0A3S7X2X3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_290033800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2X3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290033800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4080"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001352">
        <property type="entry name" value="DNA repair helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002687">
        <property type="entry name" value="Helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="813"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="953" mass="104318" checksum="0A077CD0DD8D8C80" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3R0</accession>
    <name>A0A3S7X3R0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase associated with various cellular activities (AAA) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Replication factor C, subunit 2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Replication_factor_C_subunit_2_putative/GeneDB:Lm jF.30.2630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_6520</name>
        <name evidence="9" type="ORF">LdCL_300031800</name>
        <name evidence="10" type="ORF">LDHU3_30.3520</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3R0"/>
    <dbReference type="SMR" id="A0A3S7X3R0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3520"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5432286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="354" mass="38440" checksum="6E5542FB1F110012" modified="2019-05-08" version="1">MSSSSQPAQKRAKTEGASDTAGAAAPWVEKYRPRTLAEVEAQDEAVGALRACLKEGANMPHFLFHGPPGTGKTTSILAVAHELFGPDYIRSRVRELNASDDRGINVVREKVKIFAQGAVSSSGSSVTQSDGKVYPVPPFKLIILDEADALLPDAQAALRRMMEDFSDVTRFCILCNYVSRIIDPIASRCAKYRFKPLVKSALYHRIEYVAQAEGITLSPASLHALDTVSGGDLRLAIMHLQSAQKAKGDDLSKEDFVSVSGSVPADVMQRYLSALFSHRLEEVIQASRRLVAEGFAAAQVLLQMQHYLVSAECPLNSAQRGKIMLKLCQTERRLADGGDDYLQLLDIGSAVCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X459</accession>
    <accession>E9BMI1</accession>
    <name>A0A3S7X459_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mevalonate kinase</fullName>
            <shortName evidence="10">MK</shortName>
            <ecNumber evidence="10">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_12020</name>
        <name evidence="14" type="ORF">LDBPK_310580</name>
        <name evidence="13" type="ORF">LdCL_310011300</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="10"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863148.1">
        <property type="nucleotide sequence ID" value="XM_003863100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X459"/>
    <dbReference type="SMR" id="A0A3S7X459"/>
    <dbReference type="GeneID" id="13385869"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0830"/>
    <dbReference type="OMA" id="GPFFDAP"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000127">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000024">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="11">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="12">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="329" mass="35602" checksum="EF81351F5039CE00" modified="2019-05-08" version="1">MPKPVKRKTTGKNIGYGKVILFGEHFVVHGAEAIVAGISEYTECRLEINPGVPGLQVDDQRPAIPGYIAQKRDEQIKAHQLVLDHLKVDLSRDGLKMLIGGPLVPSSGIGASASDVVAFSRALSELYQLNLTDEEVNQSAFVGEGGYHGTPSGADNTAATYGGLISYRRHDGKSAFKPIAFQQRLYLVVVGTGINASTAKVVNDVHKMKKQQPAQFKRLYDNYTHIVSQAREALQKGDLQRLGQLMNANHDLCRQIDVSCRELESIVQTCRTYGALGAKLSGTGRGGIAVALAASSDQRDAIVKGLKAKCPEAKFIWRYTVQPSTASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4C6</accession>
    <accession>E9BMN3</accession>
    <name>A0A3S7X4C6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_11710</name>
        <name evidence="3" type="ORF">LDBPK_311080</name>
        <name evidence="2" type="ORF">LdCL_310017400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863200.1">
        <property type="nucleotide sequence ID" value="XM_003863152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4C6"/>
    <dbReference type="GeneID" id="13385919"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1800"/>
    <dbReference type="OMA" id="FMPATVD"/>
    <dbReference type="OrthoDB" id="268032at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="978" mass="94902" checksum="E542CAAA03A76F7C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4E5</accession>
    <accession>E9BMP4</accession>
    <name>A0A3S7X4E5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-like Heme/Steroid binding domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_3540</name>
        <name evidence="8" type="ORF">CGC21_11650</name>
        <name evidence="6" type="ORF">LDBPK_311200</name>
        <name evidence="4" type="ORF">LdCL_310018700</name>
        <name evidence="5" type="ORF">LDHU3_31.1960</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863211.1">
        <property type="nucleotide sequence ID" value="XM_003863163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4E5"/>
    <dbReference type="SMR" id="A0A3S7X4E5"/>
    <dbReference type="GeneID" id="13385930"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1960"/>
    <dbReference type="OMA" id="YIDHEHP"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="162" mass="17225" checksum="732C5AF927174669" modified="2019-05-08" version="1">MPENIRYRFFFKGKSYLIPKDYIDNEHPGGSDEIMPYVDKDMTDAFEDADHSLNAVDMLEEWLDEEYDLGIQPDPTAVASPAQEGAKTAGPATEASPPAAAATPAVRIATPTVSTAPAATAPTTASEPSKSKLFVPVAATAAAVAVLMASATLVYVRVPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4I7</accession>
    <name>A0A3S7X4I7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_310020800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2270"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="831"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="677"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1489" mass="157095" checksum="B00FB2A7ED8D743C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4P3</accession>
    <name>A0A3S7X4P3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannosyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_310027000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4P3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3440"/>
    <dbReference type="OrthoDB" id="263469at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46656">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46656:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="820"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="966" mass="105716" checksum="D21CAEE16F93C83E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X718</accession>
    <accession>E9BPL6</accession>
    <name>A0A3S7X718_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LIM domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">LIM domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">LIM_domain_containing_protein_putative/Pfam:PF004 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_10080</name>
        <name evidence="9" type="ORF">CGC21_37265</name>
        <name evidence="8" type="ORF">LDBPK_332780</name>
        <name evidence="6" type="ORF">LdCL_330034900</name>
        <name evidence="7" type="ORF">LDHU3_33.3920</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864102.1">
        <property type="nucleotide sequence ID" value="XM_003864054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X718"/>
    <dbReference type="GeneID" id="13392498"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3920"/>
    <dbReference type="OMA" id="FHEGCLH"/>
    <dbReference type="OrthoDB" id="249790at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5433484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP53602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP55422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="429" mass="45062" checksum="6A002586CF72CF89" modified="2019-05-08" version="1">MEQQGEAEAPPSPTQPTDAPTVKTSSADGASGAPPSAANAPAGTKGINSVLQQVDGPVVATGHAQEDGANAPTAVVRGKASAKAVKREVGSSRVDGTPSAIAASSTSLVFSQGSNKTDNHMPHSTAPVHLGDGVQYSSAIAVGSAHTAAPHQPRLSSSPRYSHSGRQVISDACKRSEPFLRGADGNYSTVYAASGLTVNAQYQTIPEEHAEYRQRNKVNLNYRGPLYVVEDVCVPCNACGGPVDPVRRVPVGSLFFHEGCLQCYLCGRRTGVAGLYMQVDRQAVCSECAGRGYEHWVPRQEVESRGMVYGATRGDVYAAMDAHDRGAAKHRQRRIGSLPITAGGGPSTLNKAIVPGALPPTLSIANVHNRRNTSARSFALMERQQYYTQSDNNVIMALPASAARPPSVTGGRKGSTAPLQYRLTSGRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X791</accession>
    <name>A0A3S7X791_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330038300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X791"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4500"/>
    <dbReference type="OrthoDB" id="277789at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000258">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="657" mass="69270" checksum="E34B1DF3C00891F5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X835</accession>
    <name>A0A3S7X835_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tuzin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340034200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X835"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4300"/>
    <dbReference type="OrthoDB" id="269909at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34157:SF2">
        <property type="entry name" value="TUZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="559" mass="62301" checksum="E697018EE0FDC4C1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8R5</accession>
    <accession>E9BRP7</accession>
    <name>A0A3S7X8R5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_0860</name>
        <name evidence="9" type="ORF">CGC21_5695</name>
        <name evidence="8" type="ORF">LDBPK_350150</name>
        <name evidence="6" type="ORF">LdCL_350006500</name>
        <name evidence="7" type="ORF">LDHU3_35.0220</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864608.1">
        <property type="nucleotide sequence ID" value="XM_003864560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8R5"/>
    <dbReference type="GeneID" id="13387486"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0220"/>
    <dbReference type="OMA" id="AHRMNGG"/>
    <dbReference type="OrthoDB" id="261678at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="4">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5434043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ37926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP46514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="290" mass="31293" checksum="B20C821B0C4AE0F0" modified="2019-05-08" version="1">MSSVLTGALAYGSSVFTIVALYPYRDFVKSADVRHLPCAKDLGDYCAKRYRGMLGSLSQPMLLAAPHAALYFGYVFAAGGAAGALLGGLLFGYTKTFVRAVAYRMNGGGSRYSKPVQRGYSGLLDCVVLSAKHYGVLSFFPGALAASVVGVLWYGISLAVLQQTYSRSFGEDLWNAFRVHALLTFLTAPVRNTMRSSMYPSERSGGVHAVRDYVATEAAVFREAGGVFLSMAREEGLRFFFNGTLRTTFKSSVPFAVTYALFKAIGGSIGLPTGGAYRGGRIGRHFSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9Z4</accession>
    <accession>E9BSR3</accession>
    <name>A0A3S7X9Z4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calmodulin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Calmodulin-like_protein/GeneDB:LmjF.35.3890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_353930</name>
        <name evidence="3" type="ORF">LdCL_350044400</name>
        <name evidence="4" type="ORF">LDHU3_35.5100</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864972.1">
        <property type="nucleotide sequence ID" value="XM_003864924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9Z4"/>
    <dbReference type="SMR" id="A0A3S7X9Z4"/>
    <dbReference type="GeneID" id="13387849"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350044400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5100"/>
    <dbReference type="OMA" id="NPTNEEM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5434415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15708" checksum="C679B6AA5B1C9C85" modified="2019-05-08" version="1">MKEAFELLQRDGKIPKASVPTALRAAGLNPSEEKIKEIMVTATDVDMAGYEALVEKHDDKMDTAEAVKEAFRVFDKDLDGTVSVAEFRHIMTTMGEKYHEEEFRELIQGFEDNGVIHYEKFVDKMLAPFTEHGSAEDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAH4</accession>
    <name>A0A3S7XAH4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HORMA domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_360016800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAH4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1510"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000019">
        <property type="entry name" value="Predicted HORMA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="539" mass="58665" checksum="6A590AFA7D95CBF2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJI4</accession>
    <name>A0A451EJI4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_020010000</name>
        <name evidence="3" type="ORF">LDHU3_02.0570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5427007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJI4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0570"/>
    <dbReference type="OrthoDB" id="253002at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21644" checksum="0099D0A4E94EDF93" modified="2019-05-08" version="1">MAGGKSSKRVKLRTKIARRQQTQHATDEHAPSSSGLSSSPPPVGGAGEATAAPPTEVDRQAALHIRDALRQRQGRTGRAPAMKVKEARGVRATAAPVGAKRKHAMNAKKDKPSSQRTAALRRATVLERRRLTLPRMSAAETRMTVAQEELQLFDAVQTVPAYAEDPFAAVMQHLSATMDVLQPQTPDVGIAARAVGARRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJT3</accession>
    <name>A0A451EJT3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_030013500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJT3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_013360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0920"/>
    <dbReference type="OrthoDB" id="277162at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="969" mass="103106" checksum="2B4A7A135895F34A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7T5</accession>
    <accession>A0A3S7WNN0</accession>
    <name>E9B7T5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase/Type III restriction enzyme, res subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_030670</name>
        <name evidence="8" type="ORF">LdCL_030011900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858032.1">
        <property type="nucleotide sequence ID" value="XM_003857984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13390408"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0760"/>
    <dbReference type="OMA" id="ISGCGDH"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="PhylomeDB" id="E9B7T5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1617"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1575"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1575"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1598"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2209" mass="246691" checksum="5B91AC04EE44E330" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7W5</accession>
    <accession>A0A451EJU5</accession>
    <name>E9B7W5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_030950</name>
        <name evidence="2" type="ORF">LdCL_030014800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858062.1">
        <property type="nucleotide sequence ID" value="XM_003858014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7W5"/>
    <dbReference type="GeneID" id="13390671"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.1060"/>
    <dbReference type="OMA" id="FVQGQWI"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="PhylomeDB" id="E9B7W5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36060" checksum="CF78AECA522724BA" modified="2011-04-05" version="1">MPSDGEGKVRQVNIDEIDAVTGFKKAELYVWNAYAAAFLAEGGEPETDVEAWIDDFCQRSEESGAVFDRNFVKSVCTLGIYAGPRDEFQQRSGCGKATYASGDTYEGEFFEGKKHGRGQYIFVSKGRSEADRVVSKEVELLTGAGKDAKAMVAEIANKLQLGRHVVEGVMQYGQRPCYHGDYVRGKRTGRGVMKNKDGTLYQGEFLENKRHGQGVYYYLNGDVYSGNWKAGAKDGYGTYHFADGSEYRGEWVRGNFVQGQWILQGGSYYEGKFDKKNRPLDDAASLHYPSIQMAQTGAFKRGVWAPTSALQVCSEVPVDGMAWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAB7</accession>
    <accession>A0A3S7WR67</accession>
    <name>E9BAB7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_100720</name>
        <name evidence="7" type="ORF">LdCL_100014000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858908.1">
        <property type="nucleotide sequence ID" value="XM_003858860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAB7"/>
    <dbReference type="GeneID" id="13392232"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1050"/>
    <dbReference type="OMA" id="PWTWLLH"/>
    <dbReference type="OrthoDB" id="238351at2759"/>
    <dbReference type="PhylomeDB" id="E9BAB7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="324" mass="36335" checksum="148824A04C35FD14" modified="2011-04-05" version="1">MALAATWNPQRQFRFPSVNLRTSPVSCGATPTPTFLRRARLSTPSLLSQNVIQYRWMRAKNQQQQDRNAEETGKEGEESNSKTEGGDQGSDQQSGSSAKGSKNKKGVKGQAKKKSLMDHVRGLRDDYANFPHIYNSVNAINFVVFTVFCLCSTGSNTEERWWLEKWGVDNSVRPWTWLLHSFLTNNFLAMTYAMMLLHTMCHHVLPTLGSRGLMMYCGGTAVFSGAIMWLSNYLYYGSAAAPEKQFGPWDVIAALFVMEYLYYGVTPMSILSSFSGWIKYACWVGGVCILYFDWQPTLIGTLVGLAFCKGVPRWQAVRPTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAJ0</accession>
    <accession>A0A3S5H6H6</accession>
    <name>E9BAJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_110020</name>
        <name evidence="8" type="ORF">LdCL_110005100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858980.1">
        <property type="nucleotide sequence ID" value="XM_003858932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAJ0"/>
    <dbReference type="GeneID" id="13389811"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0030"/>
    <dbReference type="OMA" id="ISGERHY"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="PhylomeDB" id="E9BAJ0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF27">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="150"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="368" mass="41383" checksum="F151653A1416AA20" modified="2011-04-05" version="1">MFPKPKEDYQREQTRWGALLSVFTVFFVIFLVLWEGAAYLRGRDAYDTDVSLDKGLSEDMPVHFDVLFPFMPCNRLSIDVVDTTGMAKFNYTGRLHKLPTALDGEVVYKGSLKDLDNEMETREGRAGKKCRPCPPSAFDGVPAEVRSAAELKCCDTCESVLDLYKELGKGIPGTEYIPQCLEQLYQRASGCTVMGSLDLKKVPVTVIFGPRRTGHFYSLKDVIRLDTSHFIRKLRIGDETVERFSKNGVAEPLSGHKSSSKTYSETRYLVKVVPTTYRKTKTKNAKASTYEYSAQWSRRTIVVGFAGAVPAVLFEFEPAPIQVNNVFERQPFSHFLVQLCGIVGGLFVVLGFIDNVVDWVGAFGKWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAJ4</accession>
    <accession>A0A3Q8IB58</accession>
    <name>E9BAJ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_110060</name>
        <name evidence="8" type="ORF">LdCL_110005500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858984.1">
        <property type="nucleotide sequence ID" value="XM_003858936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAJ4"/>
    <dbReference type="GeneID" id="13389492"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0070"/>
    <dbReference type="OMA" id="NIRACIR"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="PhylomeDB" id="E9BAJ4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001895">
        <property type="entry name" value="eIF-2 alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001010">
        <property type="entry name" value="eIF-2 alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="177"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124296" checksum="585E085B85199994" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCL4</accession>
    <accession>A0A3Q8ICF1</accession>
    <name>E9BCL4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypanosoma Tc-38 (p38) protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_160100</name>
        <name evidence="2" type="ORF">LdCL_160005900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859698.1">
        <property type="nucleotide sequence ID" value="XM_003859650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCL4"/>
    <dbReference type="GeneID" id="13393066"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0110"/>
    <dbReference type="OMA" id="SATEECM"/>
    <dbReference type="OrthoDB" id="245678at2759"/>
    <dbReference type="PhylomeDB" id="E9BCL4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="1">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="327" mass="36328" checksum="5DFBF58387CFA9BE" modified="2011-04-05" version="1">MAHPCLQQGGRTAAAKASQTLCGHTFSAEHHRFLCSIAQTRGWAGRVWVPVPVVERLSLRLADSPFTPARLVSSNGSVCVYHSSQFVEPLDVLRERWKAHVRGLENAEKDRNAALLASQAAPDALPLSTNGERFDSATEECMLRIMSSRANASRYWATEAEAKWLYRAPFTDAHLSDPGNRVVSHANELCRPMALYNVAGTADPSRFTPLTCRRYDPVNYAGRFYRPAVAVRMKAFALQYNCLHERQWITQRRAMGLGLSILPHIPLLAFSLDMPLFLINIGATHRRSAPAPRVSPAIAADCIVTSEDVLEAPERQCERRLLLPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEF0</accession>
    <accession>A0A3S7WVN6</accession>
    <name>E9BEF0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ELMO/CED-12 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_191600</name>
        <name evidence="2" type="ORF">LdCL_190021800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860333.1">
        <property type="nucleotide sequence ID" value="XM_003860285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEF0"/>
    <dbReference type="GeneID" id="13386144"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1940"/>
    <dbReference type="OMA" id="RLWNGHN"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="PhylomeDB" id="E9BEF0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="57"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="248" mass="28582" checksum="AE41751AF1C1C443" modified="2011-04-05" version="1">MERSLYYTPQLLWLQVMDRMPYELTHYFVSSPPPHHEAMLSGIREQYGRPYSAEKPFDVELLGRLWNGHSRVMFATDNLVFSAAAHSVSDRWKEMGFQGTDPSTDFRGAGIFGLAQLVYLVEHHPEQWSAILTPDFMAAAAGLNVTMRLATLLGINSSLNQFSSSVLSTYSAREARLRLCRFIFDPSVDVATQRLSEVYCFAMRLLHYRWMRSTRNIMELNQQLSNMYTELDRLLFLCNTLEELCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGP5</accession>
    <accession>A0A3Q8IBS9</accession>
    <name>E9BGP5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ethanolamine phosphotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_240330</name>
        <name evidence="12" type="ORF">LdCL_240008200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861123.1">
        <property type="nucleotide sequence ID" value="XM_003861075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGP5"/>
    <dbReference type="GeneID" id="13390573"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0380"/>
    <dbReference type="OMA" id="YRAHITH"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="PhylomeDB" id="E9BGP5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="902"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="977" mass="106041" checksum="982DCAD32B5CA85B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJI1</accession>
    <accession>A0A3Q8IDU9</accession>
    <name>E9BJI1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_281110</name>
        <name evidence="3" type="ORF">LdCL_280015700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862209.1">
        <property type="nucleotide sequence ID" value="XM_003862161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJI1"/>
    <dbReference type="GeneID" id="13386945"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1360"/>
    <dbReference type="OMA" id="MRFARFE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="E9BJI1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="70356" checksum="618AABEBFB9FF486" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKM3</accession>
    <accession>A0A3Q8IF18</accession>
    <name>E9BKM3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_290770</name>
        <name evidence="16" type="ORF">LdCL_290012400</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862494.1">
        <property type="nucleotide sequence ID" value="XM_003862446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKM3"/>
    <dbReference type="GeneID" id="13387233"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1050"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="PhylomeDB" id="E9BKM3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001161">
        <property type="entry name" value="Peroxisomal targeting signal 2 receptor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="15">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU80561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="373" mass="40723" checksum="B841BE97EFF94C3A" modified="2011-04-05" version="1">MPSFQMHPGFAGQSIRTNPWKPTQLIISTSQNFGIVGSGKVYVVEAAPGFQAGSPVSLVGCWGTPDGVFDACFSEADQNIVVTACGDGVKVYNLAMSLNRDGVIPLVQNAEHQAEVSCVAWNSGRRDTFYSASWDTTIKMYSAVKPEVSMVTMQEHFKEVYEVATTGHSPSSILSCSGDGSWKLWDNRSPQRSVLTQMAHQNQIVLSIDFCKSDPNIFASGGVDRTVRVWDARRPNQPLASFPGHDQACRRVRFSTSSPSMLASSGYDMRVCVWDLSKPQQPLTARYQHHREFVVGLEWSQAAPNALASASYDGSAFFWSVGQAATPSLPTQQLPPAVPPPRVPRPRTKVLAGLPQPSMPMPMTMTSLPRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BM84</accession>
    <accession>A0A3S7X3V3</accession>
    <name>E9BM84_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calmodulin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_303410</name>
        <name evidence="6" type="ORF">LdCL_300039700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863052.1">
        <property type="nucleotide sequence ID" value="XM_003863004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BM84"/>
    <dbReference type="GeneID" id="13385761"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300039700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4510"/>
    <dbReference type="OMA" id="CILMLQR"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="PhylomeDB" id="E9BM84"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000623">
        <property type="entry name" value="Putative calmodulin-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="725" mass="81130" checksum="FE27DD738D2A782C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMA6</accession>
    <accession>A0A3Q8IFW3</accession>
    <name>E9BMA6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger CCCH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Zinc finger-domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_303630</name>
        <name evidence="8" type="ORF">LdCL_300041700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863074.1">
        <property type="nucleotide sequence ID" value="XM_003863026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMA6"/>
    <dbReference type="GeneID" id="13385783"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4820"/>
    <dbReference type="OMA" id="WEQTGTC"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="PhylomeDB" id="E9BMA6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="269" mass="29841" checksum="3A892ACBA3CC3178" modified="2011-04-05" version="1">MTFSVKGGSYSSSHPSPAMHPYVSPSLPPQSHGQQAPPSFSLGDEQYVGVPKRVGVDPTKYKTTICRNWEQTGTCTFRGCTFAHGVEELRAPLRPDGHTPVLRPQHISPGSTPPLRASQPPPPPPPPSSGHYTLEQLLDMLYKEVLHQRELVTVHVEANTTLEGMLRREQAQHDLSKKQLEEKTQQCELLARELFARNQQLRKAADSSPEIKGLLDQWETQLASFSEADAKKDDVFYTATATSSTDDGGDSGKEYESARIEELLRALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BN12</accession>
    <accession>A0A3Q8IFQ8</accession>
    <name>E9BN12_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-nitrophenylphosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_312410</name>
        <name evidence="1" type="ORF">LdCL_310032200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863329.1">
        <property type="nucleotide sequence ID" value="XM_003863281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BN12"/>
    <dbReference type="SMR" id="E9BN12"/>
    <dbReference type="GeneID" id="13389661"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4300"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="PhylomeDB" id="E9BN12"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="413" mass="44031" checksum="8227C43081A5AD49" modified="2011-04-05" version="1">MKPASPPCAAVQASSLRSCFIPPHLSFPVTAPGPPYTDRNNVPRQILSAMPEQMTAALAARLVASPLKYVLLDIDGVIWCGGHVIDRVPETLQYLRGQGKQIRFLSNNASLSREQLLQSLKAKGIEGVTMEECYNSAYTAALRLRQLLGKADVPGEEPLVHGNVFVIGEQGLHDELQQVLAPGFITYGVELHDAERAGGYDTDALGSAWRVPCLPPPQKRLVVCNGKTCRMVQAGTNSAEKISLSDLNAAAVVVGLDKHFNILKLAYGSLALQGPPKDLREESHTPPLFVATNEDPQLPVGRDGTMIPGAGSMVSALCTAVGKRPDAVCGKPHKDMANILFAAEGITNPREECIMIGDRLTTDVAFGNAAGCQSMLVLSGVEGLADVEEAEKQGKTALMPKYVAESLACFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNJ1</accession>
    <accession>A0A3Q8IFC8</accession>
    <name>E9BNJ1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_320870</name>
        <name evidence="3" type="ORF">LdCL_320014200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863504.1">
        <property type="nucleotide sequence ID" value="XM_003863456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNJ1"/>
    <dbReference type="SMR" id="E9BNJ1"/>
    <dbReference type="GeneID" id="13390317"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1100"/>
    <dbReference type="OMA" id="DPVTIFH"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="PhylomeDB" id="E9BNJ1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012389">
        <property type="entry name" value="Cyclin_P/U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027110">
        <property type="entry name" value="PREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR027110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18911" checksum="A2A418D417A95A55" modified="2011-04-05" version="1">MPPLAQLCALALQYRCDLSQETDQNIRSCFHSSRVPSISLWDYVRRFAKYSVCSEECFILAMVLMDRYVCKTRIPITLRNVHRLYITAMTLSVKLRDDSYYSNAYYASIGGVVNAELNVLELELLDIVQWFTWVEKSVYDAYVARLEALFGDAMPKRLVASPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPP1</accession>
    <accession>A0A3S7X784</accession>
    <name>E9BPP1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_333030</name>
        <name evidence="2" type="ORF">LdCL_330037400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864127.1">
        <property type="nucleotide sequence ID" value="XM_003864079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPP1"/>
    <dbReference type="GeneID" id="13392523"/>
    <dbReference type="KEGG" id="ldo:LDBPK_333030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330037400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4220"/>
    <dbReference type="OMA" id="GIDRAGY"/>
    <dbReference type="OrthoDB" id="272689at2759"/>
    <dbReference type="PhylomeDB" id="E9BPP1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44279" checksum="2BF2D49B27C2EEA3" modified="2011-04-05" version="1">MASASAMGPSSSASPPRHWGSDLLLRKVPLYAQARQYAAVDPDDPQSEGNTLGYGPSSYPLLAAVRSCYDMLNRDEVAAETFSLGATTAVVDRSPFNGIDRAGYAHVPAQRKWAVADPLAADSASPNSEQSTALARRAAAAALLDDAIGPATLAQVLEPWFGVIEDRLCAGAQQQQVEELVRSENQKRGKEAAKRSSNGAAESLEDVENVENGSVRVADADASRMLGRKRLYDREEETHGAVYTRLESAILHYSAATQEEKEVLRSTRVANSDSSADAPVPGEGSTAAPPSQETWGSRMLLLVTSTVAAEAGSGAARRSDEEVEQQQKVLAYLKRVRWIATQWNSNANQVAFKDAGASAPSWGQMTEAQRVKAEMLHAQGQRRRFRRPRRGGDGGARGNGDDADAALENELGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BS31</accession>
    <accession>A0A3Q8IF12</accession>
    <name>E9BS31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_351550</name>
        <name evidence="2" type="ORF">LdCL_350020400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864740.1">
        <property type="nucleotide sequence ID" value="XM_003864692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BS31"/>
    <dbReference type="GeneID" id="13387620"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2070"/>
    <dbReference type="OMA" id="DWALMGQ"/>
    <dbReference type="OrthoDB" id="273058at2759"/>
    <dbReference type="PhylomeDB" id="E9BS31"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="679" mass="73728" checksum="83B383029A642A37" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUI2</accession>
    <accession>A0A3Q8IJK3</accession>
    <name>E9BUI2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_364740</name>
        <name evidence="2" type="ORF">LdCL_360054500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865588.1">
        <property type="nucleotide sequence ID" value="XM_003865540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUI2"/>
    <dbReference type="GeneID" id="13388474"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360054500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6370"/>
    <dbReference type="OMA" id="RPPYQWR"/>
    <dbReference type="OrthoDB" id="271870at2759"/>
    <dbReference type="PhylomeDB" id="E9BUI2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114136" checksum="9730FE0854E7AD41" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8P4</accession>
    <name>A0A3Q8I8P4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140006600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8P4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0230"/>
    <dbReference type="OrthoDB" id="264045at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="685" mass="73230" checksum="C167E1040B88918D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9D9</accession>
    <name>A0A3Q8I9D9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Surface antigen protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120012900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9D9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1260"/>
    <dbReference type="OrthoDB" id="509867at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018613613" description="Surface antigen protein 2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="66860" checksum="539C22934298CE3F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA38</accession>
    <name>A0A3Q8IA38_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAP/OAS1 substrate-binding-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_180019700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1820"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022108">
        <property type="entry name" value="DUF3648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058920">
        <property type="entry name" value="PAP-OAS1-bd-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058921">
        <property type="entry name" value="PAP/OAS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979:SF30">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979">
        <property type="entry name" value="PAP/OAS1 SUBSTRATE-BINDING DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12364">
        <property type="entry name" value="DUF3648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26180">
        <property type="entry name" value="PAP-OAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAP/OAS1 substrate-binding-related" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1673"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1987"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2023"/>
            <end position="2037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2046" mass="210540" checksum="B05E1FAECEA3382B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA85</accession>
    <accession>E9BF23</accession>
    <name>A0A3Q8IA85_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U1 small nuclear ribonucleoprotein C, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">U1 zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_33895</name>
        <name evidence="3" type="ORF">LDBPK_210380</name>
        <name evidence="2" type="ORF">LdCL_210008600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860555.1">
        <property type="nucleotide sequence ID" value="XM_003860507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA85"/>
    <dbReference type="GeneID" id="13386383"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0400"/>
    <dbReference type="OMA" id="MNCEVER"/>
    <dbReference type="OrthoDB" id="261448at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="237" mass="25836" checksum="7FB085EA28C5BCF0" modified="2019-04-10" version="1">MDPSAVAAHGTAAGADQRHPHNGSGNGALSGGQPSEAEMKRIRQRRRLACKTPEQRRKLQQYQRRHNEKDERLYYCDYCDLFISSRHRTWMTHLRSARHTVAFQSYYDLVAHVESVWVAEINREVELARSREVHRLQQRSAGKGAATPLTAQQVAPGIVVGGAPAPGRLPPPPPFPQPPHGSAQVGPTPTIRVGAKTILPSAAFVALPSAATPSPASPLADAERSRTSENEARLSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB18</accession>
    <accession>E9BF31</accession>
    <name>A0A3Q8IB18_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_33935</name>
        <name evidence="9" type="ORF">LDBPK_210460</name>
        <name evidence="8" type="ORF">LdCL_210009400</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860563.1">
        <property type="nucleotide sequence ID" value="XM_003860515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB18"/>
    <dbReference type="GeneID" id="13386391"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0490"/>
    <dbReference type="OMA" id="GHYFTCV"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="260"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP49279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="721" mass="78345" checksum="CF1E929318506EE7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB49</accession>
    <name>A0A3Q8IB49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180013700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB49"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1110"/>
    <dbReference type="OrthoDB" id="273126at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="870" mass="91446" checksum="F9F50BB64D207DFE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBL4</accession>
    <name>A0A3Q8IBL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanases superfamily/Beige/BEACH domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_230006200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0150"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="2028"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="2210"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1554"/>
            <end position="1564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2860" mass="312867" checksum="AFB1E175A7288178" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICB3</accession>
    <accession>E9BFZ5</accession>
    <name>A0A3Q8ICB3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_221300</name>
        <name evidence="5" type="ORF">LdCL_220020100</name>
        <name evidence="6" type="ORF">LDHU3_22.1870</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860876.1">
        <property type="nucleotide sequence ID" value="XM_003860828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICB3"/>
    <dbReference type="SMR" id="A0A3Q8ICB3"/>
    <dbReference type="GeneID" id="13389599"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1870"/>
    <dbReference type="OMA" id="VWIGDCG"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000049">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF480">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5430108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25223" checksum="F2A46036DCA5B699" modified="2019-04-10" version="1">MWCLSRVALQSNRAALYMPYTPVAANPVVYFDITAEGDALGRVSVELFRDVVPRTSENFRSLCTGERGYGQCLLYYKGTPFHRIIPGFVMQGGDILTKDGRSNVSVFGYPFPDESFEGKAGKHLPGTVGMAHSGPNQNGSQFFFNLGRNEQLDRKFVVVGQVLGGWEIVNQVVKLCGSRCGTPVSRAWISDCGQSGGYMAEETQEALQGERAQHVMPGKEVLDLIQPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICG9</accession>
    <accession>E9BIU6</accession>
    <name>A0A3Q8ICG9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_270110</name>
        <name evidence="2" type="ORF">LdCL_270006000</name>
        <name evidence="3" type="ORF">LDHU3_27.0140</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861869.1">
        <property type="nucleotide sequence ID" value="XM_003861821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICG9"/>
    <dbReference type="GeneID" id="13389130"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0140"/>
    <dbReference type="OMA" id="CVMPMKF"/>
    <dbReference type="OrthoDB" id="274898at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9288" checksum="6D0444EDD74DD8E4" modified="2019-04-10" version="1">MLRRTTARFYQSVTAPIGKGCVVPMKFDSLKPAYVPKSFTTQFFVLGTWSISNMITNFVIGFLIIASANGGLSGAWPPDPHSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICH3</accession>
    <name>A0A3Q8ICH3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250016500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICH3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1430"/>
    <dbReference type="OrthoDB" id="273403at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="858" mass="95199" checksum="1C40C5521570C77C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDQ2</accession>
    <name>A0A3Q8IDQ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260022600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDQ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2130"/>
    <dbReference type="OrthoDB" id="271993at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="706" mass="75515" checksum="D0C7EFE9994C5F3F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDT0</accession>
    <name>A0A3Q8IDT0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_210005200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDT0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0040"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF14">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="346" mass="38991" checksum="1DEE961F34B4E002" modified="2019-04-10" version="1">MERDPCIHVPRTRKGGTFRHSEDVELHANDFEWDEKVAELTIAERQLVDEYMSRCMAELSRTGSWESLDEVPEKPWEMHFSATKHHFPLKNYIVHAFPLLRTVMGRRGSPAWILECGCGTGSTLLPIMRECTSPDVHFVGFDISPSALSHFRSHEIAQGYLQRNQLTLLPLAIGTSSCVTSADPTAPLAKRQRIDENATLVVDALTAADKSLQHQKFDAILLVFVLSALPTVEKMLSTIKQLKNVLKQDGILLFRDYALPDHNFFRFLSKMDNKVGNIAFAKGDCTTQVFFYKEFAAKLFSAAGLVEVDDVPSNLTYHCNRIVNRKNGKKMDKIFINGTFKLAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDW6</accession>
    <accession>E9BF65</accession>
    <name>A0A3Q8IDW6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 7">60S ribosomal protein L36, Putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">60S_ribosomal_protein_L36_putative/GeneDB:LmjF.21.0730</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L36e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_34065</name>
        <name evidence="7" type="ORF">LDBPK_210800</name>
        <name evidence="5" type="ORF">LdCL_210012900</name>
        <name evidence="6" type="ORF">LDHU3_21.0900</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="5">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 3-99</scope>
    </reference>
    <reference evidence="5 10" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860597.1">
        <property type="nucleotide sequence ID" value="XM_003860549.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="i=1-105"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="i=3-99"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDW6"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3Q8IDW6"/>
    <dbReference type="GeneID" id="13386410"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0900"/>
    <dbReference type="OMA" id="WGINRGH"/>
    <dbReference type="OrthoDB" id="276730at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP49305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="105" mass="11972" checksum="A0DB2F3823F9F89D" modified="2019-04-10" version="1">MSAPTPRTGIIAGFNKGHVTTRRPRQPSPNDRFAVPHKHLRAVKAIIADLVGLSPLEKRVQEFLRVGKEKRALKYCKKRLGDFTAAKKKRSKMEEALRHTTKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK9</accession>
    <accession>E9BGE1</accession>
    <name>A0A3Q8IEK9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_17090</name>
        <name evidence="7" type="ORF">LDBPK_231270</name>
        <name evidence="6" type="ORF">LdCL_230019800</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861020.1">
        <property type="nucleotide sequence ID" value="XM_003860972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK9"/>
    <dbReference type="GeneID" id="13390220"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1670"/>
    <dbReference type="OMA" id="HEQNIHI"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP50235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="449" mass="48229" checksum="983D7D81F946516D" modified="2019-04-10" version="1">MQPIPTAHIKKVLRKEQLLRLRRWAKSEPAQVTAASQQICDHVYEYIIARYRPGATSAARGASSSSLGAAESRGAPLPAPLSPPPLLVLAYLPLYFEVDPVPLMQRLWSIAHEQNIHILTPVVLPETMTALLTARAAAVPAVELTPQPASSTVMSDPLPPQHPAPHTLKSAMVFVEVLNERELNTVFAPQGAYNIREFNASLLEPWLLGPSRTSTIGMPAPLHSPSTLEGVKGDDEDDHAMLASCHGRHRHMVLCDAYARLFPEPHAAGYRPSGLLEYRDASEDPRTRLSPAVHEGATHALGSLDDVSMLVLAPGVLFDVRTGSRLGKGGGFYDRFLDYHGSVHRRRLPADSVPSRVGGQEEGNTAESVEAAVGASTLAASGVPVPQWDVMALAFDDQVLRSSTTGTCAPAIGVSDSSMPSRIPADTHDRPVHSVVSPSGGVEQVCQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEP2</accession>
    <name>A0A3Q8IEP2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_300006200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEP2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0210"/>
    <dbReference type="OrthoDB" id="272779at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="427" mass="47046" checksum="FCC678A80727AAB4" modified="2019-04-10" version="1">MDTQGICAISEYVARGHDSGVVWAWCAASPAAFAAVISSPSRTRQAAHERSVHYLPSYEQKSGCVCTVRVDRMGITLNDFHHRVPPWLVTWHTQLLFRLFGPAGVAVHVTDLDSLVLDSLLSAWEGTPVQVTALTSRHRLSTCVSAHRRSTGRVFSALSGLQDLVLLPSPSVHGSLAVAKYAPLLRRVTASKCCVECLKPLSQLQHLQEVQLSQTLIRDAELRILAQLPLLTTLDVSSCPHLSSLEPLACAASLRILRASSCERLMLVAQLGTLATLRIVDLSGNVFLPTEFATFITQPTLHLQTGYFAHMRWPRDDPPPTQVLGSVKHLHLSYGTVPNIRWLCGAHSLEQLCLDHTNVTAVEMAVLVQHTPLLSVLSLSYCEHLHTNLDFTRSLRFLATLTITRSSLPYPFPELVELQQSLSLMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEQ8</accession>
    <accession>E9BJU1</accession>
    <name>A0A3Q8IEQ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">DNA-directed_RNA_polymerase-like_protein/GeneDB:L mjF.28.2060</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">RNA polymerase Rpb3/Rpb11 dimerization domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_13030</name>
        <name evidence="11" type="ORF">CGC21_22545</name>
        <name evidence="9" type="ORF">LDBPK_282200</name>
        <name evidence="7" type="ORF">LdCL_280027100</name>
        <name evidence="8" type="ORF">LDHU3_28.2980</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862319.1">
        <property type="nucleotide sequence ID" value="XM_003862271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEQ8"/>
    <dbReference type="SMR" id="A0A3Q8IEQ8"/>
    <dbReference type="GeneID" id="13387055"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2980"/>
    <dbReference type="OMA" id="HEMRCER"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5431603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP40421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP54350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="137" mass="15333" checksum="63AB25BE48341CD4" modified="2019-04-10" version="1">MASFHPRDAFILHQEHIQRMNEGDEVDTSEEQKVQIDLQRITDNESTAVVTFSHEDHTLGNPLRHVLMQNAAVTSAGYAIPHPLEPKMLLHVQASDYAVEAVAKGLERLAEICDDTISSFDNCMVEQHRMAAATQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IES8</accession>
    <name>A0A3Q8IES8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Subtilisin-like serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_280030500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3440"/>
    <dbReference type="OrthoDB" id="260818at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1634"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1669"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1696"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1734" mass="187555" checksum="5EE638658BCD5C07" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEU3</accession>
    <name>A0A3Q8IEU3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300015200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEU3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1310"/>
    <dbReference type="OrthoDB" id="271850at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000034">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="334"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="717"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="761" mass="82797" checksum="463DB8B540D87166" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFA5</accession>
    <accession>E9BFJ2</accession>
    <name>A0A3Q8IFA5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CGC20_21940</name>
        <name evidence="20" type="ORF">CGC21_34640</name>
        <name evidence="19" type="ORF">LDBPK_212060</name>
        <name evidence="17" type="ORF">LdCL_210026300</name>
        <name evidence="18" type="ORF">LDHU3_21.2450</name>
    </gene>
    <organism evidence="17 23">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 22" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 23" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 23">LdCL</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860723.1">
        <property type="nucleotide sequence ID" value="XM_003860675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFA5"/>
    <dbReference type="GeneID" id="13386474"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2450"/>
    <dbReference type="OMA" id="RTEHSYE"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAC5429940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP54595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="251" mass="28174" checksum="3DA0EE0EA1334BB0" modified="2019-04-10" version="1">MVTETFLRKALFARCAIDLCGKKILPKDAFVALLTQGKLTPSQYQMTDAEAVKYIDTLKRAKMIVEVDDYVYTDVKAVVDAVHLKSGLPLVPATSKTFENLYHALSESLAAFHRQSLPAAERAVRRQREFWAFTALGSGTQMLVLAYLTFQVYGWDVMEPVTFFVTTATALCSYAYFLYFRAEHSYESVDDSFLPHLLMRELGVLRVDADKAIRDMKAMQELQAAVSLDDERVSKLVEAAAKKKSTSACHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFM2</accession>
    <accession>E9BR23</accession>
    <name>A0A3Q8IFM2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_26420</name>
        <name evidence="4" type="ORF">LDBPK_342250</name>
        <name evidence="3" type="ORF">LdCL_340030200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864384.1">
        <property type="nucleotide sequence ID" value="XM_003864336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFM2"/>
    <dbReference type="GeneID" id="13392793"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3740"/>
    <dbReference type="OMA" id="SVINKWD"/>
    <dbReference type="OrthoDB" id="272020at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668">
        <property type="entry name" value="HYPOTHETICAL TRANSMEMBRANE PROTEIN L6586.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="138" mass="14890" checksum="E8FF6B825C15FD35" modified="2019-04-10" version="1">MGFGTRSCMVFCYLNGVCAVFISYLFKIGIDSMAITSVINKWDRQEKARACRNAGILYLILAVAVTVKDAIDTCRERRLSRGVDQRMAEYGVADAHAGAEETVPLLECSAYVHGDGTRRRSVAGRGGSGSGGYGGAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFP5</accession>
    <name>A0A3Q8IFP5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320009700</name>
        <name evidence="3" type="ORF">LdCL_320009900</name>
        <name evidence="4" type="ORF">LdCL_320010100</name>
        <name evidence="5" type="ORF">LdCL_320010300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFP5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0600"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114385" checksum="D6D226D43AA3D59C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFX2</accession>
    <accession>E9BTJ1</accession>
    <name>A0A3Q8IFX2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 8">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_12970</name>
        <name evidence="12" type="ORF">LDBPK_361320</name>
        <name evidence="10" type="ORF">LdCL_360018300</name>
        <name evidence="11" type="ORF">LDHU3_36.1660</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 8"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865248.1">
        <property type="nucleotide sequence ID" value="XM_003865200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFX2"/>
    <dbReference type="SMR" id="A0A3Q8IFX2"/>
    <dbReference type="GeneID" id="13388133"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1660"/>
    <dbReference type="OMA" id="WRAVITI"/>
    <dbReference type="OrthoDB" id="275758at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020015">
        <property type="term" value="C:glycosome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044164">
        <property type="term" value="C:host cell cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052553">
        <property type="term" value="P:symbiont-mediated perturbation of host immune response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052562">
        <property type="term" value="P:symbiont-mediated suppression of host immune response"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5434702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ38570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP48244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="371" mass="40720" checksum="806398420EC2E18D" modified="2019-04-10" version="1">MSRVTIFQSQLPACNRLKTPYESELIATVKKLTTPGKGLLAADESIGSCTKRFEPIGLSNTEEHRRQYRALMLEAEGFEQYISGVILHEETVGQKASNGQTFPEYLTARGVVPGIKTDMGLCPLLEGAEGEQMTEGLDGYVKRASAYYKKGCRFCKWRNVYKIQNGTVSESAVRFNAETLARYAILSQISGLVPIVEPEVMIDGKHDIDTCQRVSEHVWREVVAALQRHGVIWEGCLLKPNMVVPGAESGQTAAPAQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINNSPLPRPYFLSFSYARALQSSALKAWGGKDSGVAAGRRAFLHRARMNSMAQLGKYKRADDDASSSSLYVKGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG67</accession>
    <name>A0A3Q8IG67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketoacyl-CoA thiolase-like protein, putative</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_310023700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG67"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2870"/>
    <dbReference type="OrthoDB" id="241374at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050521">
        <property type="entry name" value="3-ketoacyl-CoA_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42689:SF1">
        <property type="entry name" value="ACETYL-COA ACYLTRANSFERASE FADA2 (3-KETOACYL-COA THIOLASE) (BETA-KETOTHIOLASE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="6">
        <location>
            <begin position="218"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="358" mass="38088" checksum="FAD32061063C8614" modified="2019-04-10" version="1">MPKKIIGNLTSMACASGLSSLSQACMLIEGGHADVVIAGGSDSVSNTEVPLPRSVTYGLMMAQRKGVMGFFKEAGYNPFKWFPGGIALTERSTGKTMGWHGDLIAELNSISREDQEALAVTSHANAARAEKAGYFKEEIVPVTIDKKGKKTEVTCDDVMQRDTEKMKAKMPSLKPVFRKEGGTITAATSSTLTDGGSAMLVMSEEKAKKLGYPTDVCVKSWYFSGIDPYPQLLLAPVLGWGPALKKAGLTPKDIDLYEIHEAFAAQVLATIKCLKSQEFFDRYANGAKPVLTEDIDLSKLNVNGGSLALGHPFAATGGRIVTSLANELRRSGKRHGLVSICAAGGLGGVAILEHTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG89</accession>
    <name>A0A3Q8IG89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320042100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG89"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320042100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4570"/>
    <dbReference type="OrthoDB" id="273743at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="401" mass="42940" checksum="0C21A2E9A385AD2A" modified="2019-04-10" version="1">MRLLVVYNRPWYAYALLVLFSLFFGLSYASVMYLEEDQSELRDRATSVAFVLFLFVGVGAVTLTAHLLLCRQLDSEEEPSFIEDAGQRRRLPKLWSYSVLFFSASVAAIALSHFISFTVAVVMVISLACHLVAELHNRGDGGDCVTRQDALGCATAGLGAALVVLGGLWQEMATYHASLGEALLSLLGWGSSVIVSGVCWACFTRQLREMSQRVSQQFLLSTSLVMCTVALGIGTYVANVALTSDETSSAALAGVAAQTTGGAEAASALQLLDLVLLPCHRFFPDVVVLLGGGLCSLLCWYAYHAVSFYVDHASSAACMVLGAVLSAVPLIVARVLRIGWADVTASALLQGSLAVMVVGVVAVEAGSAVVVWSGFRYRREVEIRIVLEKSRFSFPRANANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGU3</accession>
    <accession>E9BNX0</accession>
    <name>A0A3Q8IGU3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_322180</name>
        <name evidence="2" type="ORF">LdCL_320027200</name>
        <name evidence="3" type="ORF">LDHU3_32.2700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863632.1">
        <property type="nucleotide sequence ID" value="XM_003863584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGU3"/>
    <dbReference type="SMR" id="A0A3Q8IGU3"/>
    <dbReference type="GeneID" id="13390920"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2700"/>
    <dbReference type="OMA" id="FNPYYKQ"/>
    <dbReference type="OrthoDB" id="271360at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10323" checksum="35C6BA64455D51D4" modified="2019-04-10" version="1">MRLTAGKIYFWGSVAIIFLTAWNRRSTTQLRTVVDNLKEERMREAERLRQHQLGGQGGASGAPMMTSVSSMPKHFNPYHKQQEIESASADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIE6</accession>
    <name>A0A3Q8IIE6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350048800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIE6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350048800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5790"/>
    <dbReference type="OrthoDB" id="277434at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="249" mass="28748" checksum="BB1F9E4FF1670134" modified="2019-04-10" version="1">MKRFSSVLPAAVLGYGSATAVRAHRRYAAAVADADERVNAQQQQDEKPEAHRQQQQRTAAEENALGSTADEEPPRRRNIVVLSNTTKAVYVHPTNHIASWYWFITDFHKWFVGIVFLFVGTQVIARYRVSKLQTATQAQLGENLLDQRTRDLLSDIEVLRKKDPIRLEHEANIYHEQFWKRRALAVTSSRNEVRSLEIQRGKMQGEARGTDMTEWLGAKAKDDEEREVARRTQDYIQGFHQHLKSKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIY8</accession>
    <name>A0A3Q8IIY8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360007900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIY8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0410"/>
    <dbReference type="OrthoDB" id="272795at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="816" mass="88251" checksum="F25A791AEA741DA8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ37</accession>
    <accession>E9BTV7</accession>
    <name>A0A3Q8IJ37_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC21_13525</name>
        <name evidence="13" type="ORF">LDBPK_362480</name>
        <name evidence="12" type="ORF">LdCL_360030500</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="10"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865363.1">
        <property type="nucleotide sequence ID" value="XM_003865315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ37"/>
    <dbReference type="SMR" id="A0A3Q8IJ37"/>
    <dbReference type="GeneID" id="13388249"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3310"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="269391at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ38686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP48355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="331" mass="35493" checksum="0ED67022272C9439" modified="2019-04-10" version="1">MVKVGINGFGRIGRVVFRVAQTRPDIEIVGINDLLDAEYMAYSLKYDSTHGRFNGTVQVKDGALVVNGKTIRVTSERDPANLKWGEIGVEVVVESTGLFLTHETAHKHIEAGAKRVVMTGPPKDDTPMFVMGVNHTTYNGQPIISNASCTTNCLAPLAKVVNEKYGIAEGLMTTVHATTATQKTVDGPSLKDWRGGRGASQNIIPSSTGAAKAVGKVYPALNGKLTGMAFRVPTPNVSVVDLTVRLEKPATYKDICAAIKAAAEGEMKGILGYTDDEVVSSDFNGVALTSVFDAKAGISLNDHFVKLVSWYDNETGYSHKVLDLVLYTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK24</accession>
    <accession>E9BUW4</accession>
    <name>A0A3Q8IK24_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mkiaa0324 protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Mkiaa0324_protein-like_protein/GeneDB:LmjF.36.582 0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_15295</name>
        <name evidence="4" type="ORF">LDBPK_366070</name>
        <name evidence="2" type="ORF">LdCL_360068100</name>
        <name evidence="3" type="ORF">LDHU3_36.8000</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865719.1">
        <property type="nucleotide sequence ID" value="XM_003865671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK24"/>
    <dbReference type="GeneID" id="13388606"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360068100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8000"/>
    <dbReference type="OMA" id="WTETHSL"/>
    <dbReference type="OrthoDB" id="273779at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="500" mass="56431" checksum="BA1EE11AB0509E0E" modified="2019-04-10" version="1">MFSRSMRALVSKRPPFASFYKAVYSPLRNTEQARKMQTAAVLWHRTAPQYGIRFSAPRVAAALRIYRRKGKEITKELQKTAKPARKWKAAPSRSKLARATAPKRKAIHLKQRQQKGKKAITPFAAFQTEVMRRTKFPSTRANLKRVLRMWVMTGRQRSLSVPKRVEMAVRLLQKDRKRGKGFSRKMSNKITRRRSKRGTRKIAKSSAAGSSRKTAKSRKPRVTATGAKRARAARPSRSAVAQRLKRARRMRAVRQVPKRPASVKVRLARHLAAKRSAPKPVAASKPKARTMHAARKATASKRRTRKTSIAAVAKPRPRHTPTKRRASAARRRANPYIKFYRHMRMTGLIPNHPKILGTRQIKALWTETHSLNGLNRRIARATELLEERTGLKSKVNPPAVRTSARKRQNPKHGSPGPSPAPAAPKTSESLTIKQRDIKVPPYYSSNPFGATYAALLPLLRDIPSSTRMAHVAKAWTRTSVKDDKRSAKARIAAVAEAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK91</accession>
    <name>A0A3Q8IK91_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_360031200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK91"/>
    <dbReference type="SMR" id="A0A3Q8IK91"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3390"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000334">
        <property type="entry name" value="Methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39902" checksum="1DF383D282037457" modified="2019-04-10" version="1">MSAGGRETAPTNLIRRRNKDETNGDVSAAADRFRDRFEKATLEERKAATTTMVNEYYDLVTDFYEYGWGQNFHFAPRYAGETFFESLARHEYFLAARGGFMEGDHIVDVGCGVGGPARNMVRLTRCNVIGVNNNDYQISRARRHDALAGMSSKIDYVKTDFCNMSLADNTFDGAYAIEATCHAKDKVKCYSEVFRVIKPGTCFVLYEWCMTDKYNPNDEYHRTIKHRIELGDGLPEMETCKQVIEYMKQAGFVVEEAIDVISQFESSPIKSIPWYQPLVGNYSSLQGLRSTPIGRILTNVMCRVLEFVRLAPKGTYKATEILEEAAESLVVGGQLGIFTPSFYIRARKPSKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL79</accession>
    <accession>E9BFG2</accession>
    <name>A0A3Q8IL79_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_211760</name>
        <name evidence="2" type="ORF">LdCL_210023400</name>
        <name evidence="3" type="ORF">LDHU3_21.2070</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860693.1">
        <property type="nucleotide sequence ID" value="XM_003860645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL79"/>
    <dbReference type="GeneID" id="13386460"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2070"/>
    <dbReference type="OMA" id="KMCMREL"/>
    <dbReference type="OrthoDB" id="267536at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="283" mass="30266" checksum="3356200FB5178160" modified="2019-04-10" version="1">MERGRSCRCCGCTMQFCPCCGAALAGKRDGAVKGHSNGNDGGLLSCNSSLRPHSAAERAVGSGASVPWSHGTAAWRKRLPRRPVSAYEVYLAAVHGVVADEGGKEAAAASRTLADPRPAMAAAEGGQRSDEQVRAAALSWLRMTPAEKRVYEEEAHSWQTRLGALSTVPPSAHNLGEDSSSAAALPDALPSVERPLSQQQHSSHLVAQRSSKTPAPERLPRSKSSFALFRAHMKGRRKMCMRELCAVWRNMSAEEKAPYDAAAASKRTEQFLSQTLSAPDSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM07</accession>
    <name>A0A3Q8IM07_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_230011800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM07"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0870"/>
    <dbReference type="OrthoDB" id="277322at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46368:SF4">
        <property type="entry name" value="OS10G0403700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40475" checksum="1D9C485B9DC56E24" modified="2019-04-10" version="1">MSSDTIRVGFLGASTIAHKVWAAIEAAGNMQVTLVGSRSVKVAQKFIDECTESLHISEERKAAAATYDEVVGSSNVDVVYMSIPVTTRHEWVMKCAENNKHVVGEKPPASTPAQLQSWIEALSAKGLLYMDGTMFSHGPYVKKVVELLPEIGDIRRMTFIFSFRASPERLQSDIRCNPNLEPLGALGDIGWYGIRSFLHMVDFTMPTTVAGRILEELPNGAVTSFKGELTFPGAKPDTSIYSYFYCSFLSSLQQSFIVSGTKGRIVAEQLTSPLTDAGAACFKIVKPTFSGPDPSTDVTVEQTVTNVQVPEETGHMQETQMWRDVRDCLKKDESGRLIAEEDAVREWARKSWMTHCIAAKLMESARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IN66</accession>
    <name>A0A3Q8IN66_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD domain, G-beta repeat/Utp13 specific WD40 associated domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_250009500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IN66"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0510"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001656">
        <property type="entry name" value="WD_domain_-_G-beta_repeat /Utp13_specific_WD40_associated_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001660">
        <property type="entry name" value="WD_domain_-_G-beta_repeat /Utp13_specific_WD40_associated_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="557"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="708"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="9">
        <location>
            <begin position="849"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1017" mass="109746" checksum="A2267DAB0A367E15" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INC5</accession>
    <name>A0A3Q8INC5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_340026900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INC5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3260"/>
    <dbReference type="OrthoDB" id="277936at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018547031" evidence="3">
        <location>
            <begin position="25"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="491" mass="53246" checksum="B054547E8B00EDAB" modified="2019-04-10" version="1">MAANSQSSAVDLLRFLAISLAVHADAICCAVDDVEAAIVELSTNDELLEALENELAALLDRQRRLHVTRSMIALSQDERRRGMELRRCWRPSTQQHGNKRIQTSRTPSSRSASLKRGTPRHPGEALSMDLSADEPQQEYGASAVPTRGLSTATSSTAPCTESDADSVDAQVERLKARIMHLDRYSLRGKLLHLESQKNAVKEIDLEELVARVVDPFEFPASVRALWCSAASPRSTGSQASSCAPLTGASHRRSRSGDITLAQHATGKGGVVNHTNIDLLLARACQRLSGRAADALEALASTNVSEASAAAHLLGCMVYAAELDSSGSTDLAAVQQLQTMPRDTLSHLYDQCVRNSVCEAKLDGRCFGVRGTVLAAQDFNALPAEWATSQSLSHVPLDEILPPVRHLLSPRFSFVDVAELKQLQEKRVTLQEKLVKLLVDGQEKDAELLRDIAGSQRDRAVAAARLAVAEMSPASTSAHAWKTMVLVRDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IND2</accession>
    <accession>E9BHL7</accession>
    <name>A0A3Q8IND2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CorA-like Mg2+ transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">MGT2 magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_8620</name>
        <name evidence="8" type="ORF">LDBPK_251130</name>
        <name evidence="7" type="ORF">LdCL_250016700</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861443.1">
        <property type="nucleotide sequence ID" value="XM_003861395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IND2"/>
    <dbReference type="SMR" id="A0A3Q8IND2"/>
    <dbReference type="GeneID" id="13388689"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1450"/>
    <dbReference type="OMA" id="IFGMNCE"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000047">
        <property type="entry name" value="MGT2 magnesium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF95">
        <property type="entry name" value="MGT2 MAGNESIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP40726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="413" mass="46019" checksum="0C717B88342B2F35" modified="2019-04-10" version="1">MMRSKLDGVTSGVAEAHQLSPLVARQRYLTVNRSGGSFWFVRKDVMLKNLQVSQDSTLWLDVEGETPEERRAILNDLPWRVNIPSAVLDAVARPTESDVVELQPSLAQYAHGVLSCAINPLYDTTDETAAVDEDNFSGEAFDAARGFVWCSVLITDTLIVTMHDKRFLGLEEVVRALEMRMNPMDTTSLGNSVLTPSIVFATLVAYSSEMMLPDPTTLLSEVDCIDEMVLLIAPGVRDQPDLLRRIALLRRRISSFRGLLYMKEKLLRELVTPSMRGSFVACDMVHVMPIYKEALDKNTKMADRLDDARDILNQANLNFVTGVSMRMSQSSANMDFKMQILSQVAVICLPLNLLASIFGMNCKVAWQADDYPDLRAFWGIVALMVAWVLVCSIPTIRHILRGNAAKAIVPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISU5</accession>
    <accession>E9BN32</accession>
    <name>A0A3Q8ISU5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_10975</name>
        <name evidence="4" type="ORF">LDBPK_312620</name>
        <name evidence="3" type="ORF">LdCL_310034200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863349.1">
        <property type="nucleotide sequence ID" value="XM_003863301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISU5"/>
    <dbReference type="GeneID" id="13389681"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4670"/>
    <dbReference type="OMA" id="RGNMANR"/>
    <dbReference type="OrthoDB" id="264366at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="788" mass="86475" checksum="CC6DDDC976001694" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITG5</accession>
    <name>A0A3Q8ITG5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP deaminase, putative</fullName>
            <ecNumber evidence="3">3.5.4.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320032700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3360"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000005">
        <property type="entry name" value="Adenosine monophosphate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000003">
        <property type="entry name" value="Putative adenosine monophosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF6">
        <property type="entry name" value="DEAMINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1612" mass="179260" checksum="DCC69890EABBE0EE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4X0</accession>
    <accession>E9B7E3</accession>
    <name>A0A3S5H4X0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CGC20_4560</name>
        <name evidence="28" type="ORF">CGC20_4565</name>
        <name evidence="29" type="ORF">CGC21_17735</name>
        <name evidence="30" type="ORF">CGC21_17740</name>
        <name evidence="26" type="ORF">LDBPK_010790</name>
        <name evidence="21" type="ORF">LdCL_010012900</name>
        <name evidence="22" type="ORF">LdCL_010013000</name>
        <name evidence="23" type="ORF">LdCL_010013100</name>
        <name evidence="24" type="ORF">LDHU3_01.0890</name>
        <name evidence="25" type="ORF">LDHU3_01.0900</name>
    </gene>
    <organism evidence="22 32">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="26 31" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 31">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22 32" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 32">LdCL</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">FDAARGOS_360</strain>
            <strain evidence="29">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="33" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="34" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="24" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812621">
        <property type="protein sequence ID" value="CAC5426953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812621">
        <property type="protein sequence ID" value="CAC5426954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000060">
        <property type="protein sequence ID" value="TPP49230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000060">
        <property type="protein sequence ID" value="TPP49231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000041">
        <property type="protein sequence ID" value="TPP54505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000041">
        <property type="protein sequence ID" value="TPP54506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857892.1">
        <property type="nucleotide sequence ID" value="XM_003857844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4X0"/>
    <dbReference type="SMR" id="A0A3S5H4X0"/>
    <dbReference type="GeneID" id="13389738"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0900"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17939">
        <property type="entry name" value="DEADc_EIF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16 27" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 22" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="57"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU75590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AYU75591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AYU75592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAC5426953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAC5426954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CBZ31166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="TPP49230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="TPP49231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="TPP54505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="TPP54506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="403" mass="45327" checksum="97FB8FCE6AA92DCD" modified="2019-04-10" version="1">MAQNDKIAPQDQDSFLDDQPGVRPIPSFDDMPLHQNLLRGIYSYGFEKPSSIQQRAIAPFTRGGDIIAQAQSGTGKTGAFSIGLLQRLDFRHNLIQGLVLSPTRELALQTAEVISRIGEFLSNSSKFCETFVGGTRVQDDLRKLQAGVIVAVGTPGRVSDVIKRGALRTESLRVLVLDEADEMLSQGFADQIYEIFRFLPKDIQVALFSATMPEEVLELTKKFMRDPVRILVKRESLTLEGIKQFFIAVEEEHKLDTLMDLYETVSIAQSVIFANTRRKVDWIAEKLNQSNHTVSSMHAEMPKSDRERVMNTFRSGSSRVLVTTDLVARGIDVHHVNIVINFDLPTNKENYLHRIGRGGRYGRKGVAINFVTEKDVELLHEIEAHYHTQIDELPVDFAAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H529</accession>
    <name>A0A3S5H529_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030007500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H529"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0260"/>
    <dbReference type="OrthoDB" id="264739at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33524" checksum="B493BA6A69EC4504" modified="2019-04-10" version="1">MAAQPGRVCVSAELSQRYCCAVGHRITAATRGEVPLPASFTGSKQPTVEDLFASRFGTTTFGHRRDTSATDAPPPASPSAGVDALFTERFPALTAQATAERMHEVAASHVTTKTQSAMWDGLRRCFKFRGRLPSARINNSMGDRPSPAQPPARFSSQYPPVANEASGLSASRHQPPPPEVQRYWHSYQLWVSLQPHIQQEQQAVLQLRAQAHAAKIAQQKSLRQHLHRTMYWTLFVVCPLLGLLFLWLAIDAAAYGAELELLPFVKYDEALRDFAEAEGRHRQFIRGKSNNGVAKKKNIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H532</accession>
    <name>A0A3S5H532_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_030007800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H532"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0290"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16693" checksum="0A37AFD23727747C" modified="2019-04-10" version="1">MERDKVDATAGGLMRVNTGVFQACADALEKRYEAEVEASRHRRRCRRRACTSTRAACTMLPSSATLTRAALRSRGTTTARASTQVFHDECDLHAYTKSALNMLPRYRASSMLGPLGEYEKHQREMAYKDFTIRRDRGLVGQAMFLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5M1</accession>
    <name>A0A3S5H5M1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_050016400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5M1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_051110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1240"/>
    <dbReference type="OrthoDB" id="262747at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="928"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1243" mass="132432" checksum="5C673E06EE46BAA8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5S6</accession>
    <name>A0A3S5H5S6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060013200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0940"/>
    <dbReference type="OrthoDB" id="267971at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1705"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2049"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2147"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2225"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2330"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2703"/>
            <end position="2768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2804"/>
            <end position="2884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2930"/>
            <end position="2950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2969"/>
            <end position="3018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3064"/>
            <end position="3089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3229"/>
            <end position="3254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3299"/>
            <end position="3343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1721"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1943"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2008"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2067"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2156"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2330"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2341"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2439"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2751"/>
            <end position="2768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2868"/>
            <end position="2884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2930"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2969"/>
            <end position="2979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="3000"/>
            <end position="3011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3069"/>
            <end position="3089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3305"/>
            <end position="3319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3322"/>
            <end position="3334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3343" mass="337888" checksum="ED1AF8A850E351AF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5W8</accession>
    <name>A0A3S5H5W8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070007500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5W8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0310"/>
    <dbReference type="OrthoDB" id="271558at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="607" mass="67997" checksum="31D88E563292AECB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6G6</accession>
    <name>A0A3S5H6G6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_100015000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6G6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1180"/>
    <dbReference type="OrthoDB" id="265239at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018666571" evidence="2">
        <location>
            <begin position="23"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="551" mass="59931" checksum="C5C32D6156ECF4AC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7G2</accession>
    <name>A0A3S5H7G2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_260018400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7G2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1580"/>
    <dbReference type="OrthoDB" id="273492at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1191" mass="125614" checksum="17571C3F5222A6A6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7X5</accession>
    <name>A0A3S5H7X5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340038600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7X5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340038600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5100"/>
    <dbReference type="OrthoDB" id="272421at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118700" checksum="A14DC94E0AA537A4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNQ6</accession>
    <accession>E9B829</accession>
    <name>A0A3S7WNQ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Zinc finger, C3HC4 type (RING finger) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Zinc_finger_C3HC4_type_(RING_finger)_containing_p rotein_putative/Pfam:PF13920/Pfam:PF00097/Pfam:PF13923</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_9360</name>
        <name evidence="8" type="ORF">CGC21_2760</name>
        <name evidence="6" type="ORF">LDBPK_040640</name>
        <name evidence="4" type="ORF">LdCL_040012000</name>
        <name evidence="5" type="ORF">LDHU3_04.0860</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812624">
        <property type="protein sequence ID" value="CAC5427197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000063">
        <property type="protein sequence ID" value="TPP43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858126.1">
        <property type="nucleotide sequence ID" value="XM_003858078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNQ6"/>
    <dbReference type="GeneID" id="13390737"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0860"/>
    <dbReference type="OMA" id="YNGGFCG"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5427197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="328" mass="35889" checksum="4454A1E2E84CF906" modified="2019-05-08" version="1">MEHRPRPERTFAQARYVNKSHPATATFPAACNIFASVSSGGSMALNLLRVAVPALALVMLVLWIARFVVMHIEARRMRQQATHWRTLPSYTEVQAMAAALRPTRPTSSQEAAEDTTPAAAAEAGDEVHCIICFSTVVDHPVELLPCGHQQFCARCLVQIWQCSGIYRRLRCPLCRQPAELACPVPVANSKPSVDDVLLLQNYNGGFCGTKKVSLLDCCVLRLRVITHARLLPIVIGLRIAVLHATMFAYMLMPTSLTEVVDGAVQQQQAVKPNVPSSALAAAYASVVHVFTVVVYTAARYADDFFLVAVSIILTGHLLQSALFKDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNZ0</accession>
    <accession>E9B892</accession>
    <name>A0A3S7WNZ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_24575</name>
        <name evidence="5" type="ORF">CGC21_9265</name>
        <name evidence="4" type="ORF">LDBPK_050020</name>
        <name evidence="2" type="ORF">LdCL_050005100</name>
        <name evidence="3" type="ORF">LDHU3_05.0050</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858189.1">
        <property type="nucleotide sequence ID" value="XM_003858141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNZ0"/>
    <dbReference type="GeneID" id="13391038"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0050"/>
    <dbReference type="OMA" id="CCEGAVM"/>
    <dbReference type="OrthoDB" id="274767at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="139" mass="16346" checksum="42B7611BEE4167B1" modified="2019-05-08" version="1">MLKCGGTLLKARLTAFNPWKRRPGGLQLNGRPQMINPSYFRGRYKQQNPDDPCRLLKPSHVLLKRCPACKRTMFVQIKDKDTFHMCCEGVPMKVYSDMKTVMNIEHKILTLTRQWDVENERPWSNPHRPRPKGRSKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP15</accession>
    <name>A0A3S7WP15_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_050007500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP15"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0300"/>
    <dbReference type="OrthoDB" id="251458at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="386" mass="42231" checksum="3F395D7A98BA1F30" modified="2019-05-08" version="1">MSTRPRDICTAAFEGDTARVEQLVTAAGVYSGRWHSPFVVDTSAAARDALAHWEGVGNDEDDEGYGGAEEDIEEVLGEEEMAKLKAHPVLRGIVKAYSLDEQALGGAAEDGEGAGAYMQDDDAALLDEEAEEAAEVDRRAQQGDILLYKRLLAHQLHRDSVAEHIQQHGLLRMSTTPPVDMTLYGILFSCREVPTAAVGAAVSEESSVPLQVRWQPSKRSRYAGTPLHWAVLARAHDTVRFLVEHGADCSAGLKAGTNDGAAPDAQLAMCDQKVLGSLTPARMAADNESHGTLEVLERAVAAQEARRADEEAFFIMLEKRLRRRREEYLRRFEEARAQRLREAEEARRAEAEEGEEAEESDLSGEDKNDSGSENIDTGEEDEEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPM7</accession>
    <name>A0A3S7WPM7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060015400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPM7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_061030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1170"/>
    <dbReference type="OrthoDB" id="273012at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16561" checksum="58FC4DE3A1DB397D" modified="2019-05-08" version="1">MHYTTVLAVAAPLASIALCVCAGVKDGAAHSLFLAAATFFSGVVMWLRSRYIAALYLNELQARRQHFTDSLRRRFGDGGAAAAVREASAQRDDARAAEAYAAPSPLSRPPRTAARVSPVLPAFLACCLFLISILSTISAALHAILYVRSLETEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPR1</accession>
    <name>A0A3S7WPR1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPR1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070006700"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12378" checksum="FD3367B3FB94DA4E" modified="2019-05-08" version="1">MSALRRDRHSSTFSVNGSGTVPSPCHPSGHRTPTAFQPAPVRIFTVAVSEVPGEQLQSSGTAPSVANPVASPLDLAGGAATKSRLPVLLLAWMGEPESVVADTPQHLLSCARFCQCGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQS4</accession>
    <accession>E9B9Z3</accession>
    <name>A0A3S7WQS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_7995</name>
        <name evidence="5" type="ORF">CGC21_36835</name>
        <name evidence="4" type="ORF">LDBPK_091070</name>
        <name evidence="2" type="ORF">LdCL_090016700</name>
        <name evidence="3" type="ORF">LDHU3_09.1270</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858786.1">
        <property type="nucleotide sequence ID" value="XM_003858738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQS4"/>
    <dbReference type="SMR" id="A0A3S7WQS4"/>
    <dbReference type="GeneID" id="13392186"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1270"/>
    <dbReference type="OMA" id="WEMATGL"/>
    <dbReference type="OrthoDB" id="248381at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="615" mass="67252" checksum="8BFEEE2E8B76031A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSL2</accession>
    <name>A0A3S7WSL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sin-like protein conserved region containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sin-like protein conserved region family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sin-like_protein_conserved_region_containing_prot ein_putative/Pfam:PF04801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_16980</name>
        <name evidence="1" type="ORF">LdCL_130018200</name>
        <name evidence="2" type="ORF">LDHU3_13.1550</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSL2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1550"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5428502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP50049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="697" mass="76189" checksum="76734FE171EB3AC5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT35</accession>
    <accession>E9BBZ8</accession>
    <name>A0A3S7WT35_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_141160</name>
        <name evidence="10" type="ORF">LdCL_140017300</name>
        <name evidence="11" type="ORF">LDHU3_14.1460</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859483.1">
        <property type="nucleotide sequence ID" value="XM_003859435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT35"/>
    <dbReference type="GeneID" id="13391442"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1460"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5428655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25529" checksum="36F6A13973AEB9B4" modified="2019-05-08" version="1">MSVESIMRELVSNYLSYAVVVGSSILKVPQILKVWHNHKADGISLLSLLIELLSYIISTSWGVVQGLPFRDCGENIFITLQLVVLLLLVAKLQKSTRRASLALATELLALCAFASGQVPRTIHEYVLSGQVFFNMFSRVPQIYANYRTRCRGQLSFLTFFLAFGGGVARVLTTSLNVSWDKGKAVLLVQFGVAATLNAVILAQILYYGIADRRFKRAKWSHAKAKSLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU64</accession>
    <name>A0A3S7WU64_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin, putative</fullName>
            <ecNumber evidence="9">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_160020700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="9"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU64"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1860"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.30:FF:000001">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000133">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="12"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="826"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="513"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="863" mass="95694" checksum="D901FAF74593E218" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUT1</accession>
    <name>A0A3S7WUT1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_180009100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUT1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0510"/>
    <dbReference type="OrthoDB" id="247569at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15625" checksum="5EDDD315ABB93FAC" modified="2019-05-08" version="1">MQMQRSMYARMCHTASVNISASLSSPPCASASALFVTARHFVQGGPPVPKKDIDKKRKRYLISSHTEEMEAKYQSRQRELHEYFATHEPNCPEPLPENSFVKGQFGMRRRYYVDHRGKIDPHALGNAVDEGTNAMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUX8</accession>
    <accession>E9BDN9</accession>
    <name>A0A3S7WUX8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxisomal enoyl-coa hydratase, putative</fullName>
            <ecNumber evidence="7">4.2.1.17</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Peroxisomal_enoyl-coa_hydratase_putative/GeneDB:L mjF.18.0580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_180580</name>
        <name evidence="7" type="ORF">LdCL_180010700</name>
        <name evidence="8" type="ORF">LDHU3_18.0730</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="7"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860072.1">
        <property type="nucleotide sequence ID" value="XM_003860024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUX8"/>
    <dbReference type="GeneID" id="13393417"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0730"/>
    <dbReference type="OMA" id="FQEACWA"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000159">
        <property type="entry name" value="Peroxisomal enoyl-coa hydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34297" checksum="5829F154AEE655DB" modified="2019-05-08" version="1">MKRCCRLLSAVEAASLIRRVGPFAVHRGETKGVIEILSGDPNHPVKKLNLLGLAYAAALTELSELLSEELNAEARVAIFAARDGCSFSAGIDLKELSGMRPPSGSGAAATAAASSGSKAHAMLLQNQHRVVRAFQDGISSLARCRIPIIAAIDGHCIGGATSVASSCDVRYTTARATFSVKEAAVGLAADIGVLQRLPAIIGEGRTRELAFTCRDFSGVEAKAMGFVEEVCTDYPALLTHARKRAAQIAANSPLGVQNTKLVLNWERERAAQTSLEYQAAINAFSLHCNDIPEAARAFAEKRAPVFTDYMVNPRGGLPHSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW58</accession>
    <name>A0A3S7WW58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200021100</name>
        <name evidence="4" type="ORF">LDHU3_20.2000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW58"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2000"/>
    <dbReference type="OrthoDB" id="261603at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="403" mass="44796" checksum="E51B5E992535714A" modified="2019-05-08" version="1">MQLVSDLQQRPKKGRLSIEKNIVPFYDLCTTVQFVTFLIHTVTTMIGASRTFTRSIIVQNNFELTPSLVYKTRDCSFNTVRNIYAFSAVDMTFTQSSVNDVFVDQAIQMRLAIFVCAATLLVGGLNRMLVEANVFVIKFRNFYLWKDIISATELLLLAYVMQIVATVQYPARLLQDYLRHCGVTANSYLPFISTINLWVFAGVGYLTYVVGLILYLNNALPKYGVMTPQEIEEYKAWVRSRRAEQEQVRMLIDEAKKAHARLHMLNSTDYKHGENNTLALPPSMMGPNGPMYPYPYPYGPAYPGYAPIAPSMTSAMTDPRLPAPQLFGAGMMPTPGQTGMMPPSVYDGEQPPPVDPSPYEAMGPPGATAAVSSSPGGAVSLPANMPRRRIVPSPSQVNPPMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWH7</accession>
    <name>A0A3S7WWH7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCR4-Not complex component, Not1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_210013700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0990"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000012">
        <property type="entry name" value="Domain_of_uncharacterized_function_(DUF3819)/CCR4 -Not_complex_component_-_Not1_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000006">
        <property type="entry name" value="Domain_of_uncharacterized_function_(DUF3819)/CCR4 -Not_complex_component_-_Not1_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000007">
        <property type="entry name" value="Domain_of_uncharacterized_function_(DUF3819)/CCR4 -Not_complex_component_-_Not1_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="589"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="842"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1852"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2253" mass="249065" checksum="0B21157206F55C37" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWR8</accession>
    <accession>E9BFD7</accession>
    <name>A0A3S7WWR8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_34390</name>
        <name evidence="3" type="ORF">LDBPK_211510</name>
        <name evidence="2" type="ORF">LdCL_210020600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860668.1">
        <property type="nucleotide sequence ID" value="XM_003860620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWR8"/>
    <dbReference type="GeneID" id="13386516"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1790"/>
    <dbReference type="OMA" id="FAMLFNN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="835" mass="91246" checksum="63A2070CAD7B8F26" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWU1</accession>
    <name>A0A3S7WWU1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_210025000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWU1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2310"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73407" checksum="8B624C12BCCAA33F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWX1</accession>
    <name>A0A3S7WWX1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_220007600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWX1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0420"/>
    <dbReference type="OrthoDB" id="277602at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13127" checksum="2F035B443B61F668" modified="2019-05-08" version="1">MRRSVYYMGRSFTQRHLNACSSPLATGFVRPNAFSSTAHGLVASPLCGIGCIGSGVVGANGALVASTEASLSQLLAPIIVQGKSISMLASLLCIQNISTCVCACVRVLAGFRMSCSPPSQDCLATRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXN4</accession>
    <name>A0A3S7WXN4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosome-binding GTPase/Dynamin family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_230015700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXN4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1240"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649:SF77">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11649">
        <property type="entry name" value="MSS1/TRME-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="418"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="670" mass="74452" checksum="92393AE1E7592E35" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYH3</accession>
    <accession>E9BH53</accession>
    <name>A0A3S7WYH3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophospholipase, putative</fullName>
            <ecNumber evidence="4">3.1.1.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Lysophospholipase_putative/GeneDB:LmjF.24.1840</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Phospholipase/Carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_12320</name>
        <name evidence="8" type="ORF">CGC21_16550</name>
        <name evidence="6" type="ORF">LDBPK_241910</name>
        <name evidence="4" type="ORF">LdCL_240024700</name>
        <name evidence="5" type="ORF">LDHU3_24.2340</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861281.1">
        <property type="nucleotide sequence ID" value="XM_003861233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYH3"/>
    <dbReference type="SMR" id="A0A3S7WYH3"/>
    <dbReference type="GeneID" id="13391203"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2340"/>
    <dbReference type="OMA" id="WYDILAM"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000414">
        <property type="entry name" value="Lysophospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP52315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="278" mass="30179" checksum="78DAD625712E2D70" modified="2019-05-08" version="1">MTVPIDQLTNAQIKEELRTLYAVTDFADCIEHGDLQKKLQAIRDSTPITHGLRYGTLLEIGNKSPTGVVTLVHGLGDSAYGWESVGHELLRRLPHLLFLLPTAPSRSVTINGGMSMPAWYDIIDMCNSGLLSGRQDVASVRQSCDYVRSIAHVATKKYGIAPQRVVYSGFSQGAAVSLCTGLTAHIAPAGIACMSGYLAACTDVLPRIVQKAVPITMFHGRQDPVVPISAAKETKEILEKDGGVAPISFLEYDMDHSTLPQEINDLTSFLSRVLPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYY5</accession>
    <name>A0A3S7WYY5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_26780</name>
        <name evidence="6" type="ORF">LdCL_250014700</name>
        <name evidence="7" type="ORF">LDHU3_25.1210</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYY5"/>
    <dbReference type="SMR" id="A0A3S7WYY5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1210"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF580">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5430669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="177" mass="18771" checksum="E9F8EDB176A0B80F" modified="2019-05-08" version="1">MSYTPHYPVVESNPKVWMDIEIGGKPAGRVTMELFKDAVPQTAENFRALCTGEKGFGYANCPFHRVIPDFMCQGGDFTNGNGTGGKSIYGSKFADESFAGKAGKHFGPGTLSMANAGPNTNGSQFFLCTAPTSWLDGKHVVFGQVLEGYDVVKAMEAVGSRSGTTSKPVRVAACGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ42</accession>
    <name>A0A3S7WZ42_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAP42-like family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250019700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ42"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1750"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.540:FF:000006">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="473" mass="53028" checksum="46A7C6692AC5A95E" modified="2019-05-08" version="1">MSNSTDAARDFVTVKGHFNSLCDTYIAEVVNSSLASTDATLNAQIRSLVAEFELFWRHLSAVGAFSPNDEIDDYSTTALEMLWTPYILADLFQRVQGPMKRAQDSRAGNDGDSSNGTAQQQACSADERMRGEDVLRPSEQDSGVQQMETVAHSAANLTSRSLREEELRSLSRQEALARSHAWLKVFFEWMENIELVDKKTLDTHAVYRADQRSQRVELSRTIASLRAALKAEEEKVGYLRAKRRRMRELMAEEGEAAEETGGEEEETLRARALARLKWSIYEGCHQLQISSRELSMLEALNPEQRAAISKQYQDTMDSVRRGELSLGRHTYTILPGGMMAAGTVDHPRQVRTSDIVQSGGVTAPAATATAATSSSLAIRGSRNAQLYRQQIRNELMIDRNAPTMTLQEFAELEMAEIQRQVDEAQAKQQRQAEEDARLGPDGVEERQRQKDSAWADWKDDHPAYGLTNKGNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ67</accession>
    <name>A0A3S7WZ67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_250020400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ67"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1820"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06127">
        <property type="entry name" value="DEDDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000168">
        <property type="entry name" value="Exonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="89"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="509" mass="55756" checksum="21A2042016158D2C" modified="2019-05-08" version="1">MLRRSHATLRRKASVVLKGQLNPLEALTQIQLGMTPSLPIQRGFLLEHCERQLESLGITEGKLLAMDGRLCTQLTKRIVYELYLSVPFRVFTFDMEFTGPPVFTADGPTEDITELGLYSPLLNETFSCLVQPVCGRKQGPGVEELTHITDMMLEKEGIPFVEAWQQFLNFVQTPQPDEISGSEERILLLSHGGKLADVSLIKWTLEKFHMELPPSFVFGDTIHLIRDAHRRRPVTIDKHPPSWKLVDLVQWLHIPPTLPAHRAGNDARMTWDALYHTLLRYGDDEMAPREQLVPRFFDAEAKQLLREHTARQAQERAALSLDDTFLLADVSHSASAGHADSSSIGYSAYRSASDGSGKPCKSGAATDLLDLDFDDIFSEQNKVSASAPIEEFKLDDDDDLHSISAGASSFTASRTLSSTTTSRAAALSIDAAEDDDAVSDVNAASTPTVSPDRAAKKATSGGRKGKASGSSRSKEAAEKRNKRRGSAGDDDGEEASDPPAAATRAVFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZE2</accession>
    <name>A0A3S7WZE2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat/Leucine Rich repeats (2 copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_250029900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZE2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2890"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="663" mass="74913" checksum="0B8DC3E748DF8B72" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZI1</accession>
    <name>A0A3S7WZI1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylmalonyl-CoA epimerase, mitochondrial</fullName>
            <ecNumber evidence="7">5.1.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DL-methylmalonyl-CoA racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_260005200</name>
        <name evidence="12" type="ORF">LDHU3_26.0040</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Methylmalonyl-CoA epimerase involved in propionyl-CoA metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20553"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="EC" id="5.1.99.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:20555"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="7"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZI1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0040"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000003">
        <property type="entry name" value="Methylmalonyl-CoA epimerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13669">
        <property type="entry name" value="Glyoxalase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5430838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15306" checksum="C4344F7F9F742B40" modified="2019-05-08" version="1">MPAHLWRLNHVAIAVPASRSLVEAGEMYTRIFNAKVSEPVKQEAHGVITVFVELANTKIELLHPLGDNSPISAFLERNKDGGMHHICLEVPDIAAAMQICKEANIRCLGTAPKIGAHGNPVIFLHPKDCGGVLTELEEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZU9</accession>
    <name>A0A3S7WZU9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_260015800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZU9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1300"/>
    <dbReference type="OrthoDB" id="5913609at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000211">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019189822" description="Peptidase M28 domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="59609" checksum="3C0FBAC9C5CAF576" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X038</accession>
    <name>A0A3S7X038_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SUMO1/Ulp2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_260026300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2710"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="969"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1355" mass="143539" checksum="AF31163667C1FE68" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X089</accession>
    <accession>E9BIR9</accession>
    <name>A0A3S7X089_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_262580</name>
        <name evidence="1" type="ORF">LdCL_260031700</name>
        <name evidence="2" type="ORF">LDHU3_26.3330</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861842.1">
        <property type="nucleotide sequence ID" value="XM_003861794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X089"/>
    <dbReference type="SMR" id="A0A3S7X089"/>
    <dbReference type="GeneID" id="13389090"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260031700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3330"/>
    <dbReference type="OMA" id="TWILREA"/>
    <dbReference type="OrthoDB" id="248111at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048946">
        <property type="entry name" value="Q4D059-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21630">
        <property type="entry name" value="Q4D059-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10828" checksum="B0B84A7E2DD893E8" modified="2019-05-08" version="1">MVTTVKVEIPRESIMKPSYMDDVYLLNQFDGVNDNPQEDGLPLRKWILREVHEVLAKNPRKTEVVVKLKSDKSARTEFAVAIIGDYVPNYLHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0X4</accession>
    <accession>E9BJC8</accession>
    <name>A0A3S7X0X4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ICAM-like surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_30430</name>
        <name evidence="3" type="ORF">LDBPK_271980</name>
        <name evidence="2" type="ORF">LdCL_270027100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862049.1">
        <property type="nucleotide sequence ID" value="XM_003862001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0X4"/>
    <dbReference type="GeneID" id="13386784"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3050"/>
    <dbReference type="OMA" id="LQHGICA"/>
    <dbReference type="OrthoDB" id="273163at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="39939" checksum="A644F02CE239479A" modified="2019-05-08" version="1">MAQQRGKKAALSKAAVANASASAPDPPPFFSMRSATFTDAIVITKVISVVLPLRHLRDRNILHATLLKKLLHRPYEASAEDLAQQQLLQQEAEDGAKHSRGAHSALDNRAAPTSSSSSTPYVIVHIKSAEIHADTARQVNPRGDVQVNVMVTLVAARLQHGICAGVSEASPFTSCMQVRVPTVAVSAAVAARGSTDDAATLLLGDASEAGTDNVSQEGVKDEKAEPSGDDAALDASLPATTTAAAAKRRCCTGVPEDQQLRVTARCLEDEPIVPGQAVLLISEPAAMRCMGIRPPRAAPGPFYLTETTQPAAQFSSGEAEGGPEARPKKRARKPRASAGGTGGATPARRIVSIECAIPKREEDGEGGAAASTRKGPRKRPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X275</accession>
    <accession>E9BKI9</accession>
    <name>A0A3S7X275_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_27760</name>
        <name evidence="5" type="ORF">LDBPK_290430</name>
        <name evidence="4" type="ORF">LdCL_290009100</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862460.1">
        <property type="nucleotide sequence ID" value="XM_003862412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X275"/>
    <dbReference type="GeneID" id="13387199"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0580"/>
    <dbReference type="OMA" id="TTIAMRR"/>
    <dbReference type="OrthoDB" id="251319at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="404" mass="41045" checksum="E014D06B0C4FA108" modified="2019-05-08" version="1">MGRNKPRSKAVDVTKSLLQPTSITDHIAVQVAANNVIQVAEDDLSPTQGSEAAFALRREGKLDASMKLCLNWRQGNCHNHAACSFAHVIPYFGVSSDGGGTPGTPGKPAGLNADGSGGFTYSSAAAAGEAGGRGGNAASSSSWPQKVASPLYTATTVGQRGEEDKTMPAAASAQLSAASAASVKPEVADSTDTAELGSMAPSSNASAPPPAVVSAEGLRSILVSLTAALANKAALCAISDLAEPTDADDDVDFTQPHAAWLREMAERAEEEERATLTDGAYSWQQPLKASLAEFVEVAGKSLLGEPLWQDCSAVDLYHSLADRATAAAATSMRRLLEAAQSQAQEEAAGHVAAADPRAFSTAPTPADAGGVGARAAPLTLVDLLLDEAGGADAEADSTPAPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2D5</accession>
    <accession>E9BKP6</accession>
    <name>A0A3S7X2D5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LETM1 and EF-hand domain-containing protein 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">LETM1_and_EF-hand_domain-containing_protein_1_put ative/GeneDB:LmjF.29.0920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_291000</name>
        <name evidence="11" type="ORF">LdCL_290014800</name>
        <name evidence="12" type="ORF">LDHU3_29.1370</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862517.1">
        <property type="nucleotide sequence ID" value="XM_003862469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2D5"/>
    <dbReference type="GeneID" id="13387255"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1370"/>
    <dbReference type="OMA" id="PYNTLFW"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="129"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5431808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="502" mass="56730" checksum="0AA9E6EE72052E22" modified="2019-05-08" version="1">MLRNTLVRRANAQVAKSTAKVSSASAQRVAKKPPSKVKYYMGIAYEGLRHVYHGFRLFFINTRLAWKYSRQLKKGVALTRRERLLLESSTKDLLRLVPFSFFIVVPFAELLLPVALKMFPGLIPSTFESESQGRNRLYGDAMKTLRARQRAMDYLSATALATFDKEQQEVIRRAVMGDSIAPKDIRLVAPYFGRDGPFSVFKVPDNIVVGLGRSVGVYKWYHSLLPTRVLSPIMRRSIIRRYHEAREDDRLIRLEGLDGMNNDELVKANQTRGMRWTEGTETLRVQLEWWNSLAQDDSVPYNTLWWIKPTRYSIRKSMNNLPVEQRRQLLGIQNLPETVRASLETLCETVDTMSSISDEPNSADKLVEKIEKITSSAEKSDSDIGFEGLQEAVGAYLTEENVKRMFEKLSKKKLPEESVVVSDVIECIGQETHNSSHVVSTVFDAFDYGAGSKPITEKALLGIGARCRKAVRPPPAPKAAEEKPKSTSTEEKSIEAAPPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2K5</accession>
    <name>A0A3S7X2K5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nodulin-like/Major Facilitator Superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_290021900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2K5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2360"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="586" mass="64874" checksum="70594BF264393069" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3C0</accession>
    <accession>E9BLM4</accession>
    <name>A0A3S7X3C0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_35415</name>
        <name evidence="10" type="ORF">LDBPK_301310</name>
        <name evidence="8" type="ORF">LdCL_300018300</name>
        <name evidence="9" type="ORF">LDHU3_30.1690</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15 16 17" key="7">
        <citation type="journal article" date="2020" name="Int. J. Biol. Macromol." volume="152" first="812" last="827">
            <title>Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani.</title>
            <authorList>
                <person name="Are S."/>
                <person name="Gatreddi S."/>
                <person name="Jakkula P."/>
                <person name="Qureshi I.A."/>
            </authorList>
            <dbReference type="PubMed" id="32105687"/>
            <dbReference type="DOI" id="10.1016/j.ijbiomac.2020.02.257"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH ADP AND CA(2+)</scope>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862844.1">
        <property type="nucleotide sequence ID" value="XM_003862796.1"/>
    </dbReference>
    <dbReference type="PDB" id="6K8Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-302"/>
    </dbReference>
    <dbReference type="PDB" id="6K90">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-302"/>
    </dbReference>
    <dbReference type="PDB" id="6K91">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-302"/>
    </dbReference>
    <dbReference type="PDB" id="6K92">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B=1-302"/>
    </dbReference>
    <dbReference type="PDBsum" id="6K8Z"/>
    <dbReference type="PDBsum" id="6K90"/>
    <dbReference type="PDBsum" id="6K91"/>
    <dbReference type="PDBsum" id="6K92"/>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3C0"/>
    <dbReference type="SMR" id="A0A3S7X3C0"/>
    <dbReference type="GeneID" id="13385551"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1690"/>
    <dbReference type="OMA" id="AWTHQHP"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000090">
        <property type="entry name" value="Putative Pyridoxal kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15 16 17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17 18">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17 18">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16 17">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5432149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6K8Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6K90"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6K91"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6K92"/>
        </source>
    </evidence>
    <sequence length="302" mass="33128" checksum="6A678D45A4403B5E" modified="2019-05-08" version="1">MTDDKHVLSIQSHVTHGYVGNKAATFPLQLHGFDVDAINTVSLSNHSGYPVIKGHRMDLEEFTTIMEGLRANDFLSDYAYVLTGYINNRDIVRQVAATVAEIREARQKQGKKDAVFFCDPVMGDDGRLYCKEEVVEAYRELLTHADVATPNYFEASILSTVEVKDLASAIEAANWFHTQGTPTVVIKSFAMADDPTHLRFLLSCRDKATGSTKRYTGVVPYHEGRYTGTGDVFAASLVAFAHSDPMDLAVGKAMGVLQDLIKATIERGGSGKATLSSRELRVTSYPDRLQHPSSVALVTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X453</accession>
    <name>A0A3S7X453_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310009700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X453"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310009700"/>
    <dbReference type="OrthoDB" id="244479at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21578" checksum="FBCA64A2B8D6517B" modified="2019-05-08" version="1">MALKLGVIIYVVLQFIAFLCVLIGTGVDMFYIKPGAGGGAKICVTLWGAKLDCSGPKVTNPSDKRWELCPRIRNNFRVGQAFAVITIFVYGLALLFGFLLLYCCSGFRWLCLAPNIVGAVTACVVWAVMAVTYRIKEPKCEELSIAFVYGTGFGLFVFAWILGILDIIFLMVPLQIGESGEGAEPKEQEKESQKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4F6</accession>
    <name>A0A3S7X4F6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310016900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4F6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1730"/>
    <dbReference type="OrthoDB" id="272506at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="196"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="901" mass="96246" checksum="B808483EE3323A64" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4X9</accession>
    <name>A0A3S7X4X9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetoplast-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310036800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4970"/>
    <dbReference type="OrthoDB" id="273923at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056661">
        <property type="entry name" value="DUF7759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24945">
        <property type="entry name" value="DUF7759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7759" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1291" mass="132305" checksum="A6DEFF677D52C656" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X590</accession>
    <accession>E9BNH8</accession>
    <name>A0A3S7X590_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mut7-C RNAse domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Mut7-C RNAse domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_19940</name>
        <name evidence="3" type="ORF">LDBPK_320740</name>
        <name evidence="2" type="ORF">LdCL_320013000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863492.1">
        <property type="nucleotide sequence ID" value="XM_003863444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X590"/>
    <dbReference type="GeneID" id="13390304"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0940"/>
    <dbReference type="OMA" id="FIMDFSM"/>
    <dbReference type="OrthoDB" id="269563at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081">
        <property type="entry name" value="MUT7-C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081:SF1">
        <property type="entry name" value="MUT7-C RNASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C RNAse" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="296" mass="33923" checksum="5320B98C480D8407" modified="2019-05-08" version="1">MPCNVSCSTSQHSVTDEPRFIMDFSMNKVAKYFRLLGYDTLCSRDVPQADLIPAACAEGRILVTCSRPLARSVQLHNHRVRTMRLGTAKAMTGAARHVVAYDSDGESIYSHESGEVDVELRCLFTQQWRSSEFKRAMIELIQQAGVTYDLNRVFRRCVTCNELLVTAKKEEVRGRVVAKIHEIYDEFTECPACRKVFWGFDGIFAINYKSFRSLNLLRSLCICAGAPVEEERTRLTRLRCFRSFPRIAKVLIFSYLEDVDLANMIAVFPALRDLAEEVQESRQTGEPVQKMRLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5Z4</accession>
    <name>A0A3S7X5Z4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320039900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320039900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4280"/>
    <dbReference type="OrthoDB" id="241957at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1306" mass="141727" checksum="AE829FB1A1DF072C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X794</accession>
    <name>A0A3S7X794_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_330038400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X794"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330038400"/>
    <dbReference type="OrthoDB" id="10484043at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12556" checksum="F36E1BB009210B68" modified="2019-05-08" version="1">MPLHPFAPNPWRGQRGSPCVYRMANSWCCQVRPLLCLRCCDVPRCLTPSPRLLVLSASIVALAPLFRKETEKSLCVCVCVCMSSWRSCEPCTEGEGKGVTRRYANVRDCVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8J1</accession>
    <name>A0A3S7X8J1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340047200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8J1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340047200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6060"/>
    <dbReference type="OrthoDB" id="256063at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10789" checksum="CA5DB6DBE9718CD7" modified="2019-05-08" version="1">MLNIPDYRQQPLVRMVYAWPAFLGVLLFTLLTLVGMMRCVFRGLDGGSPRYIGPNTTTSVRQDIFYVVAAPLVFQGLCVSIYTTWVSWKLFRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X925</accession>
    <accession>E9BS05</accession>
    <name>A0A3S7X925_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe(II) oxygenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">2OG-Fe(II) oxygenase superfamily, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II)_oxygenase_superfamily_putative/Pfam:PF 13532/Pfam:PF03171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_0370</name>
        <name evidence="5" type="ORF">CGC21_6180</name>
        <name evidence="4" type="ORF">LDBPK_351290</name>
        <name evidence="2" type="ORF">LdCL_350017800</name>
        <name evidence="3" type="ORF">LDHU3_35.1710</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864714.1">
        <property type="nucleotide sequence ID" value="XM_003864666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X925"/>
    <dbReference type="SMR" id="A0A3S7X925"/>
    <dbReference type="GeneID" id="13387594"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1710"/>
    <dbReference type="OMA" id="CPFGEEF"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="318" mass="36586" checksum="BEABDD92F912BE78" modified="2019-05-08" version="1">MSIVSRFIGGAKHLLKGGSMKYLAAGEPYCPFGEAFGLTILPEYILEDDASNLRKGYVDVYTRASDRIILNDGRFQLPPLPPASFMPLLERLEQDNVVPKNWLNNQTANLYEPGDFIRAHIDNLFVYDDIFAICSLGSNCLLRFVHVQNGEELDVMVPDRSVYIMSGPARYVYFHMVLPVEAQRFSLVFRRSIMESDGGFRPVKTPFKEIMPYRATQILNALYSKQVGGVRVSVDDDFLESANIGAFDTSRWVKRLHPLRDWSLLRQLDEDEARVEELREKRFIDVDFSWRYRELRSYYKAMEESLVSPHVAHVTPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9I0</accession>
    <accession>E9BSI8</accession>
    <name>A0A3S7X9I0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain type 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Dynein_light_chain_type_1_putative/Pfam:PF01221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_353180</name>
        <name evidence="2" type="ORF">LdCL_350036700</name>
        <name evidence="3" type="ORF">LDHU3_35.4160</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864897.1">
        <property type="nucleotide sequence ID" value="XM_003864849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9I0"/>
    <dbReference type="GeneID" id="13387775"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350036700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4160"/>
    <dbReference type="OMA" id="MANIDTH"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21450">
        <property type="entry name" value="DLC-like_DYNLL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000014">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19535" checksum="6D88A3623D5DDCCB" modified="2019-05-08" version="1">MADIGTHDDVALDKTLRPSQRHSNADGDGSNSSVLSDMHLSDGFPHGDAEGEDEMDIRASHVHMEALYVDLPAKQLQVIMHSALRAYNTHVFIPTRTTWRKEEGARRELERDVERTALSRIAEYIKNDITAKLGGCWHVIYGHDFATFVTHKRLCFCHFQIEGADVVVWRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9M0</accession>
    <accession>E9BSI9</accession>
    <name>A0A3S7X9M0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_7070</name>
        <name evidence="6" type="ORF">LDBPK_353190</name>
        <name evidence="5" type="ORF">LdCL_350036800</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864898.1">
        <property type="nucleotide sequence ID" value="XM_003864850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9M0"/>
    <dbReference type="GeneID" id="13387776"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4180"/>
    <dbReference type="OMA" id="STWRKFN"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="376" mass="41662" checksum="E89F8B2EB6448DC1" modified="2019-05-08" version="1">MSGEGSPVPFDAVGGHKSSIFYGETAHGGRGTLRKKTTAWEIMYYLAMELAKEDALAQQPRTTHLRGDEARAKFVRAAGKMAAFASTLFSIRFPEKYMAKSAALKPYMENTDKWVIVEAGAPARSAVLAPLFNELFDGAEQLKGFDDRYDTGIWGLGLVDETSGMQRPCIMDVKIGFIRHSPLTPEDKVTRIVNKDQKALVRDTALRICGCRRYIHAAAGTEGARASLTCERFGKDIGYAMTHVRELSTCLKMFLSIGAPLAETNEDGQLAFHTEEMGAATSTERTRMKQRIRHVRAEIKSLLDFFEGTPDGAFMLQRMAFVSASVLLLYDAVASPATARLCLIDFARSTWRKFNFDESTIGFIQGLKNLDAYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9Q7</accession>
    <name>A0A3S7X9Q7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_350044300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9Q7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350044300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5090"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002053">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="359"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="444" mass="50259" checksum="AF1D0B9A970EE6D8" modified="2019-05-08" version="1">MVKIKTISRSELEWTKDRATEVPKVNRNYDPKFNPMAKQVEFTRAVVAAKMDRMFAKPFVAALSGHQDTIQSIATDIASLSTVATGSVDGGLIVWDAMTRKQRAVINAHRHSVDGVAISPDGVACFSASRDKTVKMWDLDFDPGEESIEPVAEFLGEFPFSSIDHHFHKSWFATSSDVVNIWDVNRTQPLQRFSWGDDTVSSCQFNKIETNLVACCMADRGVFLYDVRSQSAHSKIVMEMCSTSLSWNPMDPNVFVTGSDDRNCYLFDIRVPGRPRNVFQGHIRPVTCVDFSPTGTMFAAGSQDASLRIWDLHQTSKSDSIEMFHTKRMAGVYAVKWSPDNSYIYSGSEDAVLRVWKSDASKPIRPLRGPEKHKFNYMRSLKSKYSNFVEVKRISNQRNAPKAILRTSRRIKKAEKREAVKEMSRIHGDNVKPLAKRKTYGYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAE0</accession>
    <name>A0A3S7XAE0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_360013800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAE0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1150"/>
    <dbReference type="OrthoDB" id="14717at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22981">
        <property type="entry name" value="DD_TbAK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002851">
        <property type="entry name" value="ADP-ribosylation factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051995">
        <property type="entry name" value="Ciliary_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32574" checksum="47008F801B33BE2C" modified="2019-05-08" version="1">MSKDDASIAYAKKHKIHHLFELMATKVLLNRPENPFAYLRNLLKDVEESEKNRVPYDPTQVHFNDVGAAAPAAGSSGGSAAAAPAAALTSAKKEKRTVTLATFGLDRAGKTCALSVLESGEADKKYTPTVGFAPIKFPLDDYNLCVFDLGGAANFRGIWVHYYHDCFGIVYVIDSAASDERVAESLKVLHETLQHPYVKGKPLLVLANKKDLPESRGVGVVPQGFLEEAMGESGAPHRVLATCAIEDDPALVEGIEWLLEAVSKEYDALAKRVAKDSNEVKNEKARQRAARLAAIRGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBQ9</accession>
    <name>A0A3S7XBQ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">200 kDa antigen p200</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360057400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBQ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360057400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6740"/>
    <dbReference type="OrthoDB" id="273530at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF8">
        <property type="entry name" value="200 KDA ANTIGEN P200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="101776" checksum="585B61ECD926A9B2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-20" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A2CIN8</accession>
    <accession>E9BL05</accession>
    <name>A2CIN8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">fumarate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fh</name>
        <name evidence="22" type="ORF">LDBPK_292080</name>
        <name evidence="20" type="ORF">LdCL_290026700</name>
        <name evidence="21" type="ORF">LDHU3_29.2970</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2007" name="Int. J. Parasitol." volume="37" first="149" last="160">
            <title>The Leishmania donovani complex: genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH, and FH), new targets for multilocus sequence typing.</title>
            <authorList>
                <person name="Zemanova E."/>
                <person name="Jirku M."/>
                <person name="Mauricio I.L."/>
                <person name="Horak A."/>
                <person name="Miles M.A."/>
                <person name="Lukes J."/>
            </authorList>
            <dbReference type="PubMed" id="17027989"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2006.08.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MCAN/SD/2000/LEM3946</strain>
            <strain evidence="16">MHOM/ET/2000/HUSSEN</strain>
            <strain evidence="17">MHOM/IN/1954/SC23</strain>
            <strain evidence="19">MHOM/IN/1980/DD8</strain>
            <strain evidence="14">MHOM/IN/1996/THAK35</strain>
            <strain evidence="13">MHOM/IN/2000/DEVI</strain>
            <strain evidence="15">MHOM/SD/1982/GILANI</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20 24" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 24">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12461"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:12462"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="DQ449810">
        <property type="protein sequence ID" value="ABF20382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449811">
        <property type="protein sequence ID" value="ABF20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449813">
        <property type="protein sequence ID" value="ABF20385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449814">
        <property type="protein sequence ID" value="ABF20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449817">
        <property type="protein sequence ID" value="ABF20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449818">
        <property type="protein sequence ID" value="ABF20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449827">
        <property type="protein sequence ID" value="ABF20399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862626.1">
        <property type="nucleotide sequence ID" value="XM_003862578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A2CIN8"/>
    <dbReference type="SMR" id="A2CIN8"/>
    <dbReference type="GeneID" id="13385329"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2970"/>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.130.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF16">
        <property type="entry name" value="FUMARATE HYDRATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="11">
        <location>
            <begin position="79"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="12">
        <location>
            <begin position="360"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF20382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF20385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF20386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABF20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABF20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABF20399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAC5431919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBZ35933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="568" mass="62622" checksum="797DAB9015569AAC" modified="2007-02-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFI6</accession>
    <accession>A0A3S5H7A2</accession>
    <name>E9BFI6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_212000</name>
        <name evidence="1" type="ORF">LdCL_210025700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860717.1">
        <property type="nucleotide sequence ID" value="XM_003860669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFI6"/>
    <dbReference type="GeneID" id="13386473"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2390"/>
    <dbReference type="OMA" id="NLRDQWQ"/>
    <dbReference type="OrthoDB" id="272585at2759"/>
    <dbReference type="PhylomeDB" id="E9BFI6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24711" checksum="D3DAE01E7C9BC803" modified="2011-04-05" version="1">MHLLPKAATVTKRNMHGLITGDDCSMTKTLEPSAQLHPLVGYASAVSLPTVYSALVKVTGRVLSFAAAGGEGRLSREGFRELLALIGPAEVLSTKYADTMFTSLPSYNADSDTTEALAIFTLLIEHRHHPRLNSNVEALFGAFDTDVKGVVPAEALYPDVLAAWAVQRTYGNLRDQWQRFAAVISMESERSADAFPLLPPLASRTAIRAALCSAAAIYTAACSLDLDGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>E9BK24</accession>
    <accession>A0A3S7X213</accession>
    <name>E9BK24_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_283080</name>
        <name evidence="1" type="ORF">LdCL_280036100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862402.1">
        <property type="nucleotide sequence ID" value="XM_003862354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BK24"/>
    <dbReference type="GeneID" id="13387138"/>
    <dbReference type="KEGG" id="ldo:LDBPK_283080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.4090"/>
    <dbReference type="OMA" id="MRYWAPG"/>
    <dbReference type="OrthoDB" id="272830at2759"/>
    <dbReference type="PhylomeDB" id="E9BK24"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="439" mass="47103" checksum="DD43718921E6B130" modified="2011-04-05" version="1">MSASPLVTLTGSAAGRRKSCVTRFASFDALCRAQQKPDTHALLRTELQAKLPRPSPRNDVVAVGDAAIELVLQFLGPVSRNSAAFAQTCRSVRRALFHVMDLEVAVVIPAMVVASALSRETVRRALITFAATRGAQVRTLVLHEDGLNAVKRECDDGTPVAGLTLPAPWLLQLISQLPYLTELDVRHVQFTEAHHSQALHYLLSDLHLAAAGTLCTLKMDAELMRYWAPGWWRRLVNLSSLVVGSRYCPPEPTSDTTASGISPSSLELPADYFTLMCEEGRGWKLNLWVPIQAASLKRILMPASGIIYAGVAELLVNMRCNERTCEWSDAVGGHTLPLSSPAAAIASGTASELSPETRNSGASCKAGTGAATGIESGEVCIYPALTTMTIVDVQERPEVAAEVYQAMLDMAPALVHFNVCDTVSAGTASEATKKRRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKC6</accession>
    <accession>A0A3Q8IDQ0</accession>
    <name>E9BKC6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_280880</name>
        <name evidence="2" type="ORF">LdCL_280013400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862187.1">
        <property type="nucleotide sequence ID" value="XM_003862139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKC6"/>
    <dbReference type="GeneID" id="13386923"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1050"/>
    <dbReference type="OMA" id="DWTAKYF"/>
    <dbReference type="OrthoDB" id="272782at2759"/>
    <dbReference type="PhylomeDB" id="E9BKC6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="502" mass="55459" checksum="1E436AA1F2FFA113" modified="2011-04-05" version="1">MRSSCATGALLSSVIVQHSSSPTYATARLYTSNFGKAKADAEPLDAEQPSENSDRASKGPLSSSAPSQPQQRYRRRSSDPQTPRERADFRRDYKYAKHRPLPDAPWRQLKTKTYLDDAERLYGRKETWHTVEDATLREKLVAILQDYLRDTLAAARLEAKDARKYAFLCSTAAKHYRAHVSSGAFGLPEGLQEWARGVVAGRASSPSAAKLSTTLSTTPEMEEGDAHAEEVPQETGASFAPSHAAAADEHHDDSAAAFPSQEERDAARFREERRRRGAEANLANTVAMAGLPDADSRHSPHSAFPFLRQRAVEKEATLDPSLVDWTAKYFSEDDASTFAEPPRLRAGMVEDEEGSVSDREATGDGRQEEGASPLGILGAVKGRRPSGFAPPTLPVAHRSASMHARHRLGRTLRDHENRHRATFDAEGIYYKVRRQSEVEERAPKPQQVRASDLETLGRQVDVVKVPWSVAAKAKAQGYSSDTLRAKERLIRLTRGEDPETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKF2</accession>
    <accession>A0A3S7X214</accession>
    <name>E9BKF2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_290050</name>
        <name evidence="1" type="ORF">LdCL_290005400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862423.1">
        <property type="nucleotide sequence ID" value="XM_003862375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKF2"/>
    <dbReference type="GeneID" id="13387161"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0070"/>
    <dbReference type="OMA" id="WCTLLTH"/>
    <dbReference type="OrthoDB" id="272593at2759"/>
    <dbReference type="PhylomeDB" id="E9BKF2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="672" mass="73025" checksum="6B6D3A26851BF139" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPH2</accession>
    <accession>A0A3Q8IMI4</accession>
    <name>E9BPH2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_332330</name>
        <name evidence="2" type="ORF">LdCL_330030300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864058.1">
        <property type="nucleotide sequence ID" value="XM_003864010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPH2"/>
    <dbReference type="GeneID" id="13392454"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3370"/>
    <dbReference type="OMA" id="AWNSWAN"/>
    <dbReference type="OrthoDB" id="266653at2759"/>
    <dbReference type="PhylomeDB" id="E9BPH2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33200" checksum="4261C0172D4E2BED" modified="2011-04-05" version="1">MLLSAQGRPSRLLGSFRSFPFTSAALSVAARRCQARAHHLSKRSPLSSWSALRGTRGTPCAVLPTGRRWATNCETAAFEPNRGPMLVPRRTVHSAAASAAKPANEADDTAVVETVSASSATTLQRGESATARAATAAATGAAAAAESQNTDATGDQQPSKSTTAVAIATVATPAGQASMWRRAWRVFKSEGTDFSIFYLPFYGGTFVFFYFAFAMGLMRKEAILDYVLSWMGDRVDRAKLNARIAAWNSWANLGFAIAINELVEVARLPVVFALYYVMRPHSNHFARWLAGLARRMGRGNWTDGAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ67</accession>
    <accession>A0A3S7X6L2</accession>
    <name>E9BQ67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major Facilitator Superfamily/Nucleoside H+ symporter/LacY proton/sugar symporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_331360</name>
        <name evidence="9" type="ORF">LdCL_330019800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863962.1">
        <property type="nucleotide sequence ID" value="XM_003863914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ67"/>
    <dbReference type="GeneID" id="13392357"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2020"/>
    <dbReference type="OMA" id="PQFEVIT"/>
    <dbReference type="OrthoDB" id="261787at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ67"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="130"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ37279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="591" mass="64002" checksum="432C66D540DAEC35" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BTC0</accession>
    <accession>A0A3S7XAJ5</accession>
    <name>E9BTC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_360610</name>
        <name evidence="2" type="ORF">LdCL_360011000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865177.1">
        <property type="nucleotide sequence ID" value="XM_003865129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BTC0"/>
    <dbReference type="GeneID" id="13388063"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0770"/>
    <dbReference type="OMA" id="TSANDRM"/>
    <dbReference type="OrthoDB" id="277356at2759"/>
    <dbReference type="PhylomeDB" id="E9BTC0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="308" mass="35518" checksum="13AB8AA6B821E8A7" modified="2011-04-05" version="1">MKSDDALLGPPHSMLCKYTFRITPLFSSTCRFTTAVSQLVVLHAYFSCCPCIFLSAISSNMAATSYDRDAAVKVAEENYSLRKRLARMEWEEEKQRRAAEYESRFEGAVDTSANDRMRSRNSALQDEIAGLESQLKELQMINVTDLQHEYTRLDNRRAYLLNEIAGLRRILANQSKEVKRATRSVNSQHELRRQNNEQHAASIEDIQMFRKKRESLAEETQHLIAKERQLMSELETLPAPGEDQEVMASRLREDNEKKDHTIAQLEATLKEKQLKAGTQLAEANSAVDIQHLREEYVRLNDQLKRIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q71S86</accession>
    <accession>E9B9D5</accession>
    <name>Q71S86_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Superoxide dismutase</fullName>
            <ecNumber evidence="3 7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FeSODA</name>
        <name evidence="15" type="ORF">CGC20_23300</name>
        <name evidence="14" type="ORF">CGC21_0475</name>
        <name evidence="13" type="ORF">LDBPK_080300</name>
        <name evidence="11" type="ORF">LdCL_080007900</name>
        <name evidence="12" type="ORF">LDHU3_08.0360</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2000-10" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania donovani iron superoxide dismutase A.</title>
            <authorList>
                <person name="Plewes K.A."/>
                <person name="Gedamu L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 16" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 7"/>
    <dbReference type="EMBL" id="AF312587">
        <property type="protein sequence ID" value="AAQ14562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858595.1">
        <property type="nucleotide sequence ID" value="XM_003858547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q71S86"/>
    <dbReference type="SMR" id="Q71S86"/>
    <dbReference type="GeneID" id="13391914"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0360"/>
    <dbReference type="OMA" id="DHHGNVG"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000008">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF12">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAQ14562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5427679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ31874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP49122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP54992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="230" mass="26211" checksum="2A810B35A4F0583E" modified="2004-07-05" version="1">MFRRVSMKAATATAPVGFSFLCYHTLPHLRYPAELPTLGFNYKDGIQPVMSSRQLELHYKKHHSAYVDKLNTLGKGCEGKTIEEIILATSGSTESKVMFNQAAQHFNHSFFWKCLSPGGKPMPKTLENAIAKQFGSVDDFTVSFQQAGVNNFGSGWTWLCVDPRTKELRIDNTSNAGCPLTSGLRPIFTADVWEHAYYKDFENRRADYLKELWQIVDWEFVCQMYEKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-07-24" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>R4QWJ8</accession>
    <name>R4QWJ8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_30395</name>
        <name evidence="14" type="ORF">LdCL_150016900</name>
        <name evidence="15" type="ORF">LDHU3_15.1440</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Jaiswal A.K."/>
                <person name="Khare P."/>
                <person name="Joshi S."/>
                <person name="Dube A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 17" key="2">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KC595509">
        <property type="protein sequence ID" value="AGL80637.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000037">
        <property type="protein sequence ID" value="TPP53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="R4QWJ8"/>
    <dbReference type="SMR" id="R4QWJ8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1440"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AGL80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5428811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="199" mass="22196" checksum="E861AA0261DD311B" modified="2013-07-24" version="1">MSCGDAKINCPAPPFEEVALMPNGSFKKISLAAYKGKWVVLFFYPLDFTFVCPTEIIAFSENVSRFNELNCEVLACSMDSEYAHLQWTLQDRKKGGLGAMAIPMLADKTKSIARAYGVLEEKQGVAYRGLFIIDPNGMVRQITVNDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGAPTMKPEPKASVEGYFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8J2</accession>
    <accession>E9BBH0</accession>
    <name>A0A3Q8I8J2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="7">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_33410</name>
        <name evidence="11" type="ORF">LDBPK_130960</name>
        <name evidence="9" type="ORF">LdCL_130014900</name>
        <name evidence="10" type="ORF">LDHU3_13.1180</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859307.1">
        <property type="nucleotide sequence ID" value="XM_003859259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8J2"/>
    <dbReference type="GeneID" id="13390497"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1180"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000182">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000070">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5428470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ32595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP45191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="308" mass="34780" checksum="A10F60041E10F6A1" modified="2019-04-10" version="1">MVGVLVIIAFSMAAFFAFMFTRTTKVAMDPTMFKHFKLIKRTEVTHDTFIFRFALENETQTLGLPIGQHIVLRADCTTAGKTETVTHSYTPISSDDEKGYVDFMIKVYFAGVHPSFPHGGRLSQYMYHMKLGEKIEMRGPQGKFIYLGNGTSRIHKPGKGIVTEKVDAYAAIAGGTGITPILQIIHAIKKNKEDPTKVFLVYGNQTERDILLRKELDEAAANDSRFHVWYTIDREATPEWKYDIGYVREEMFRKHLPVPDMLGSDSVPQNAGIKKVMALMCGPPPMVQMAIKPNLERIGYTADNIFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8M6</accession>
    <name>A0A3Q8I8M6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoprotein phosphatase, putative</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_130019700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8M6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1740"/>
    <dbReference type="OrthoDB" id="273392at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF514">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="118"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="433" mass="48112" checksum="6514204FD7FD3F81" modified="2019-04-10" version="1">MAERPSTLAISEAKTSNRLPDPLRSPTDRTREHLLSNRSFSSVLEAVAGGTSLSSTPDFQEEEGVQHKRTFDFFGATPHSGEFLPLIEWLLRRGERGDVGAPTASQKDGDEYTQASFFNEDYIMKLCAAATAVLVKEPTLLELEVVAHDTLVVVGDIHGQFQDLYTSVLCQQYDRRRCNPDGRDRRFLFMGDYVDRGPHSLEVVLLLLALKVEYPTLVYLTRGNHEEEKTSRVYGFLTEATSSLGAAAGTAVWSAVNKVFLDLPLAAIVQTLYMRFFVTHGGLSPVLQNVEDICALERHNYSCGNITAAEDDLIAGLLWSDPTNEVAMYEQNPRGCGFLFGPSASNRFCADNNFDFICRAHQVAMEGHMWTHNDRVLTIFSAPNYCGVNGNKGAVLLIKGCSRRPIVQQYDSAEKNETAPARKTDFAYAHMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8M7</accession>
    <name>A0A3Q8I8M7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_090019400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1540"/>
    <dbReference type="OrthoDB" id="273495at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004503">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="1685"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="1924"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2104"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1807"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2107"/>
            <end position="2126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2283" mass="245025" checksum="CC9BAE20568635BC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8N3</accession>
    <name>A0A3Q8I8N3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LdCL_100010100</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8N3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100010100"/>
    <dbReference type="OrthoDB" id="265814at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU76655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="598" mass="63532" checksum="DAB079D674FC35DA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8S9</accession>
    <name>A0A3Q8I8S9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LdCL_100011100</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8S9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011100"/>
    <dbReference type="OrthoDB" id="264225at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000003">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU76665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="599" mass="63780" checksum="2A486994C124DC77" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9J9</accession>
    <accession>E9BD10</accession>
    <name>A0A3Q8I9J9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_36945</name>
        <name evidence="6" type="ORF">CGC21_24640</name>
        <name evidence="4" type="ORF">LDBPK_161590</name>
        <name evidence="2" type="ORF">LdCL_160020900</name>
        <name evidence="3" type="ORF">LDHU3_16.1890</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5429017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859843.1">
        <property type="nucleotide sequence ID" value="XM_003859795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9J9"/>
    <dbReference type="GeneID" id="13393163"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1890"/>
    <dbReference type="OMA" id="NDADLNM"/>
    <dbReference type="OrthoDB" id="276553at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="364" mass="40148" checksum="BA392500312E7F33" modified="2019-04-10" version="1">MSFMRNRFLRSAYDELVVVGSRWTRVLAVSVDAAEVGPPHVQSHLAHPIITVIPTLHVAGIKFYDRVLEYIDHAVKRNKDTLVLLEGICDSEAAEKQQMQEYQDIMRNDALRQTMLAKADDNTLYSPEVMREICQEMDIRYELLQSMESTVRLQECYLKPKLAAMCGLNLRNHADLHMHEVQRLLEEESVRLQTLGERLPSSIAVSQLGSFPVIRKHRERKVAQVARMHCIRWFEQETDGEVIIPWGYFHTEAIIHYILEGNKSVSAAVDTNGGGVASSTGTSSSAGAASPSDEASTRSSTGPGRLSAKAAAAGGVAGAAAAIEHAPPRLVFVEADELLAKVPFSVPKELIERTPEDADSSKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBJ6</accession>
    <name>A0A3Q8IBJ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230018000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1450"/>
    <dbReference type="OrthoDB" id="246010at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2079"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2222"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2393"/>
            <end position="2414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2599"/>
            <end position="2628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2079"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2099"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2395"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2518"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2599"/>
            <end position="2627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2874" mass="304680" checksum="66D535EEC83C14A7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBL2</accession>
    <name>A0A3Q8IBL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200006800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBL2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0210"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX NUP2_50_61 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39666">
        <property type="entry name" value="RANBP2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="862" mass="93144" checksum="D6B8BA2D0C5C6B3B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC17</accession>
    <name>A0A3Q8IC17_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase transmembrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_300025800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC17"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2780"/>
    <dbReference type="OrthoDB" id="261545at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18169" checksum="FB55D24733F3210A" modified="2019-04-10" version="1">MMLAFVMVMPDAVRDSKQLRQGHRRSPLEDRPPRHEIIMRHQLASFLMELAAAGGFAAVEYTKLKKHYPHLQSLHSIVGTFCGLTIVCQIVLGSILRYLLAPANPKRPIVRTVHSCVSATIAVTAMMAMAGGFLATEYAERMIPPSLIRTAIVLAAVATTVAGFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC47</accession>
    <accession>E9BH04</accession>
    <name>A0A3Q8IC47_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_16310</name>
        <name evidence="8" type="ORF">LDBPK_241410</name>
        <name evidence="7" type="ORF">LdCL_240019300</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861232.1">
        <property type="nucleotide sequence ID" value="XM_003861184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC47"/>
    <dbReference type="SMR" id="A0A3Q8IC47"/>
    <dbReference type="GeneID" id="13391154"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1720"/>
    <dbReference type="OMA" id="CYETSIC"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000029">
        <property type="entry name" value="Putative histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP52267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="536" mass="58145" checksum="2BED728575029B71" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICB2</accession>
    <name>A0A3Q8ICB2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_150015700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICB2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1310"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000008">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34351" checksum="4ADD5723CD07D3CC" modified="2019-04-10" version="1">MSDDDVHERLTTIPGACPTPLELGMSGWNILHSSAAVYPYKPSAVQQTAMKNFIESWAHVYACSWCAYHMREYVRDHPPDVRDKLTVSRYVCEMHNDVNVRLGKDVFDCSPSVVLRRWHPGYPNKMEDMPTIEEQLAASDREKSTAKEAKHSQQEEEQRFSRSGLHAHEAAPNEAVAWRTASEAASKKVDGGLWSWRIFRKPVLGTHAAKSNAPPGTSSSSPPPTTQHEPSISSSGALKAPSTGAVAAAASDVGAAHPRHSWSTSTSEAHNSFLTPTPSRGKAADDDTDIDAVLKRLKRCQVYCPEDEELKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICC4</accession>
    <accession>E9BHC8</accession>
    <name>A0A3Q8ICC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor of RES complex family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Pre-mRNA-splicing factor of RES complex, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_8220</name>
        <name evidence="3" type="ORF">LDBPK_250240</name>
        <name evidence="2" type="ORF">LdCL_250007500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861355.1">
        <property type="nucleotide sequence ID" value="XM_003861307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICC4"/>
    <dbReference type="GeneID" id="13391524"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0300"/>
    <dbReference type="OMA" id="QRSCTDK"/>
    <dbReference type="OrthoDB" id="272513at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="186" mass="20064" checksum="2DBD453271D8EBE0" modified="2019-04-10" version="1">MSGAPAKRRRLDSEDDEDEYVALRSSSPLLQHATSARFPTDEVPTLEDGEGASDVAETLASGRAPDPATYVEADDPAEVARSAADASAAGHLSGAIAPKSHLFFEEDEDVPAEYKGLFSAELLNVLFVPLDYICKQRSCTDKLLSQYAPTEDTPHSAAERQPYHNVYGIAPGFRWDGVVRGRGPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICE6</accession>
    <name>A0A3Q8ICE6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250021400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICE6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1940"/>
    <dbReference type="OrthoDB" id="273538at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="547" mass="58849" checksum="2F8E76B454826441" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICJ9</accession>
    <accession>E9BHR5</accession>
    <name>A0A3Q8ICJ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tim10/DDP family zinc finger containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Tim10/DDP zinc finger family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Tim10/DDP_family_zinc_finger_containing_protein_p utative/Pfam:PF02953</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_8850</name>
        <name evidence="3" type="ORF">LDBPK_251610</name>
        <name evidence="1" type="ORF">LdCL_250021800</name>
        <name evidence="2" type="ORF">LDHU3_25.2050</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861491.1">
        <property type="nucleotide sequence ID" value="XM_003861443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICJ9"/>
    <dbReference type="SMR" id="A0A3Q8ICJ9"/>
    <dbReference type="GeneID" id="13388737"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2050"/>
    <dbReference type="OMA" id="RRCITHY"/>
    <dbReference type="OrthoDB" id="268856at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="102" mass="11591" checksum="2C0CEF448C2C0967" modified="2019-04-10" version="1">MQPVQSNPSLMGLTQSEAVVLSEKLYHISNEGFMYCTKKCITHYGDDAIPYHPGEKACLDRCISKVRNGMYMAIDHKKEFEQKLRSGDLPYQWMKDAAAGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEA8</accession>
    <name>A0A3Q8IEA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290012000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEA8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1000"/>
    <dbReference type="OrthoDB" id="246474at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018724434" evidence="2">
        <location>
            <begin position="21"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="711" mass="75350" checksum="54B9312347432057" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK1</accession>
    <name>A0A3Q8IEK1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amastin surface glycofamily protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280016800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1530"/>
    <dbReference type="OrthoDB" id="264655at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28627" checksum="997399531BD0E6F6" modified="2019-04-10" version="1">MIQSARSLGDSSWDSHRQTNRMDSIVNRDIDIRGSLTAKQDDTVNVSDANGAANMYESSYLNEFEYTPTPFNPRRVSRCRIENFVALATLILMLVLSALALITPLFYYRSSTATVRVDSVNVWGTGVEGVRQRYNVHTIFCDNYAAKSDGYLALYILLFLIACVGLFLSLFPIICGRVLICNYLVHTLLFLCWFFVMVAMILGVQMYRENLCHSTSLKNIGFRYGPAFGVTAALFSLLSITMIFLALRAIRNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEQ6</accession>
    <name>A0A3Q8IEQ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280012500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEQ6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0960"/>
    <dbReference type="OrthoDB" id="240272at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="394" mass="44017" checksum="958E74B9991DCBEE" modified="2019-04-10" version="1">MEGFAASAYWGATGEVPPRAPDDVASKQPYPFQAEINRKLVPLPKDQTSYPRTLDYTNVGLHLILDDGNSNIGGFNASQLQKLGEGGAGGDGLGGTQGQGNTGSQKPRFLTLQTTNQAIPRTFDDGVLDVLRAGQAKEDALKKELDNLEATPYASGAAPDAFRLTSDDYCDFGKMDPSAYRQKDWKEDGDGVYVYKSRYNNVEREGPRRRERTFQTLQRGRTVDRTQLRSTLEDSHKQALPQGYEPYSAKDWMSTTHREHAAYDVAEARHMNNRDATVPLRNTHYALSPAQEMAVTQRDARFQTRHDGKWATTYSAGYQDRSAEADVCHKYGAKAVFDIEDGIYTINHEYHHPRREVRTGETYTPAEMVPGQYTTMYTEPLPAPNSVIGSTRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IES2</accession>
    <name>A0A3Q8IES2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200009500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0570"/>
    <dbReference type="OrthoDB" id="267632at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="782"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1332"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1343" mass="146104" checksum="F2E956EBBEF2825D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF48</accession>
    <name>A0A3Q8IF48_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF572 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290018200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF48"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1800"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="477" mass="52788" checksum="4E3DF5AEF189F761" modified="2019-04-10" version="1">MSKINATYSSGYYIAPDVDFRKLEEQQRQEQRGKRKHGGADHGGDDNVKRQTFAIPFDLICEHCHRRIARGSHVYANRRATDKRYLDSIRIWELEILCRFCKGKYYLRTDPETPKDTGGYICEKGCKRVEGDFYSLNKQNQAAREEWGKAKAEAELNPLAALERENEAARELEERNRQIEEAVEERAGHDDGNLLTMLRSRPRRTEVRAAALDDDGDEDADDSGKPGTAPSSTSAEPASSPPSSSSTAFPLPKAFTLGGDGDGSGDEDEEDADERAFREFNEDMERRWRTLERQQRARQRQQEQQSIVAETTMPADEDELRRVLARYGGDRRATAEAVTTTLVQAQEPNVLQAPASASCPTPMTTSAPAVAPKKSSIKQNKFFVCNNDNDDDIDDADAEESLLARLRGPPPPKPAFVSAARATSAVSITAGATPCAQPASRFATPAGASQPPPPPRKCGSSLLRRLVDDEDDEDRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGB7</accession>
    <accession>E9BMP5</accession>
    <name>A0A3Q8IGB7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cytochrome b5-like Heme/Steroid binding domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_11645</name>
        <name evidence="3" type="ORF">LDBPK_311210</name>
        <name evidence="2" type="ORF">LdCL_310018800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863212.1">
        <property type="nucleotide sequence ID" value="XM_003863164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGB7"/>
    <dbReference type="GeneID" id="13385931"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1970"/>
    <dbReference type="OMA" id="YRVPMSF"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="130" mass="14753" checksum="6F699522A1F43802" modified="2019-04-10" version="1">MTSIATHTVTPRTVTDGAGESIWHIYEGRTYRVPMSFVRRHPNGQKLLLPYANRDITQAYNEAGHSKKAMRTLLKFLDESISIEELQSLCEKACEGPDQYTWNWCVRAGSLLSVIAVMVAVYMRCKQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH05</accession>
    <accession>E9BK25</accession>
    <name>A0A3Q8IH05_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="2 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_12645</name>
        <name evidence="16" type="ORF">CGC21_22945</name>
        <name evidence="14" type="ORF">LDBPK_283090</name>
        <name evidence="12" type="ORF">LdCL_280036200</name>
        <name evidence="13" type="ORF">LDHU3_28.4100</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="2 9"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862403.1">
        <property type="nucleotide sequence ID" value="XM_003862355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH05"/>
    <dbReference type="SMR" id="A0A3Q8IH05"/>
    <dbReference type="GeneID" id="13387139"/>
    <dbReference type="KEGG" id="ldo:LDBPK_283090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280036200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.4100"/>
    <dbReference type="OMA" id="HTWVNGT"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="156"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5431691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP54430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="324" mass="34141" checksum="FC5C740056B5F030" modified="2019-04-10" version="1">MSAVKVAVTGAAGQIGYALVPLIARGVLLGPTTHVELRLLDIEPALKALAGVEAELEDCAFPLLEKVVITADPRAAFDGVAIAIMCGAFPRKAGMERKDLLEMNARIFKEQGEAIAAVAAPDCRVVVVGNPANTNALILLKSAQGKLNPRHVTAMTRLDHNRALSLLARKAGVPVSQVRNVIIWGNHSSTQVPDIDNAVIGTTPAREAIKGGALNDDFVQVVRGRGAEIIQLRGLSSAMSAAKAAVDHVHDWIHGTPEGVYVSMGVYSDGNPYDVPSGLIFSFPCTCHAGEWTVVSGKLNGDLGKQRLASTIAELQEERAQAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH29</accession>
    <name>A0A3Q8IH29_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_090022700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH29"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1900"/>
    <dbReference type="OrthoDB" id="272048at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="607" mass="69106" checksum="1496831962A07A25" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH32</accession>
    <name>A0A3Q8IH32_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">R-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_320028400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2870"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057236">
        <property type="entry name" value="DUF7914"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25501">
        <property type="entry name" value="DUF7914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1305" mass="140455" checksum="01BB55344E54F752" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHE6</accession>
    <name>A0A3Q8IHE6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330015800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHE6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1500"/>
    <dbReference type="OrthoDB" id="264750at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1056" mass="114437" checksum="029B822CAA16FC08" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHZ9</accession>
    <accession>E9BS87</accession>
    <name>A0A3Q8IHZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_6595</name>
        <name evidence="3" type="ORF">LDBPK_352170</name>
        <name evidence="2" type="ORF">LdCL_350026600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864796.1">
        <property type="nucleotide sequence ID" value="XM_003864748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHZ9"/>
    <dbReference type="GeneID" id="13387674"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2770"/>
    <dbReference type="OMA" id="VAMRVWC"/>
    <dbReference type="OrthoDB" id="271863at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="504" mass="54633" checksum="BC47F4673C4EFD4E" modified="2019-04-10" version="1">MPASTPSAPPLRPTSNSVRSPAALDDLKLQFATEEVRKRFSDISMADMLAVLSTLLTNPRIREYGGEQAGGVLNGIHGLPLAREPKQNCASTRARRNSTSRLQQQASASSSITASELSSRDWSTRNFEMDEVPMFKAPAASRLSPEWATIVASILDNARQYREPADEHSTVVDRVQLSIKDWLENTSVEAAESEKMHAAAGSAACDSPAWLATLTQVRRLAEDVCHSKYDAVYKRLCSEAAEEGGEGMAMPVYALHDEDSTMAPSSVVARQSVHRAATGQIGIPPFSLVIQCGRDGSGTEVPDLLLSIDLDASNGGTRGSGLESSSASFVVGCEWFQWVFLVQSPLACQSEPYPEVEDGAAGKDAEAVAAEQQKWRQRHCTVQLLYPSRAGFSEGSDESSGLRSAEAEYELSEPHVVLSSLLGVAMRVWCQSHPHIVAQVLQLEEDTYPWHIYDGSLFWSAWPLSGPATHGECECAAASDSMPIPLLPGECFAHESDLKDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II03</accession>
    <accession>E9BRT7</accession>
    <name>A0A3Q8II03_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_5870</name>
        <name evidence="7" type="ORF">LDBPK_350600</name>
        <name evidence="6" type="ORF">LdCL_350010900</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6 10" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864648.1">
        <property type="nucleotide sequence ID" value="XM_003864600.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="R=1-179"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="Q=1-179"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II03"/>
    <dbReference type="SMR" id="A0A3Q8II03"/>
    <dbReference type="GeneID" id="13387526"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0740"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="275759at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000013">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <sequence length="179" mass="20789" checksum="2A9E084475899604" modified="2019-04-10" version="1">MVKPHLRHYQVVGRESPSEKNPEPTVYKFEVFAPNFVVAKSRFWRMMRVKNKVKATHGDVLSCKVVKDAKLVARNYLVDIAYYSQRCGYTRMVKEFRDVSKTGAVSQAYHDLASRHRARYHNIEVLNVKSIPDHEVKHLSIAQYHAPNLSFPLLQRRLKAARKDRAIFVKKNTKRAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II57</accession>
    <accession>E9BQH7</accession>
    <name>A0A3Q8II57_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CS domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">CS domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_25455</name>
        <name evidence="5" type="ORF">LDBPK_340230</name>
        <name evidence="4" type="ORF">LdCL_340007400</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864188.1">
        <property type="nucleotide sequence ID" value="XM_003864140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II57"/>
    <dbReference type="SMR" id="A0A3Q8II57"/>
    <dbReference type="GeneID" id="13392597"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0360"/>
    <dbReference type="OMA" id="WSKWKDE"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000039">
        <property type="entry name" value="CS domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP39937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="209" mass="22911" checksum="98B3FFC1B12F16C2" modified="2019-04-10" version="1">MSTSGPLVPPISWAQRPEYVLITIPLQDTTGVSVEIKDEGRELCFACSSPEHKQYACTIHFYGVISSEESQHVVRPRQIELKLRKKFSKSLEDANDDEVEWPRLTKEKAKYPNISIDWSKWKDENDDECAADDLGDFGLSGGDAMDGQYSEMLSQLMQAQGQKDAEESAGLPPGTIPGFGSARGQEATHGACAVAGDDDGDMPPLEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IID2</accession>
    <name>A0A3Q8IID2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_12740</name>
        <name evidence="2" type="ORF">LdCL_280034100</name>
        <name evidence="3" type="ORF">LDHU3_28.3890</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IID2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3890"/>
    <dbReference type="OrthoDB" id="266015at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="463" mass="48967" checksum="8B353404A3EF97FE" modified="2019-04-10" version="1">MSAMVLSIGIPPQERVRLCAVAAADVCQRAAAHVKAAAQCEAHDAAAAPYIRAVYVHRADSVAPERVDVASGSECGSYLRETLRATVAGIGAPSVACWLTVMLEDTCILQHAVFAISPNSKGPLKMMSPVLAQSDGAALSGGARRWSLLPAHAPGRSTSDGNVYTPRNEQPAARVLTPPLAAEAGPPLSATRRRSLGTVPCSHSARTSSKAMATAVQQPQSYAQLAPPPETQQRQQQPARSVYEQIEKYQTDTARERASSSRRSSRAAPPPDEDAATPHLSQNSDAAAPRLGGPGRKASTSSHPSSSVRSRPQSAADHSAGVYSASNTSDAVALARRDSQQPPSRAQPQPGSHPPPSGVSAERPGCRPSAVSSTSVAENFGRPPAPPSNADDPTCGGPRTDLIVPSDRQQWGDWAFRTCYSPRREELWEIADAVMTHNYCDQMIESVGEPPCDGRVSSRRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIR8</accession>
    <accession>E9BSY3</accession>
    <name>A0A3Q8IIR8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_7735</name>
        <name evidence="3" type="ORF">LDBPK_354640</name>
        <name evidence="2" type="ORF">LdCL_350051500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865041.1">
        <property type="nucleotide sequence ID" value="XM_003864993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIR8"/>
    <dbReference type="SMR" id="A0A3Q8IIR8"/>
    <dbReference type="GeneID" id="13387919"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350051500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6120"/>
    <dbReference type="OMA" id="KLCAMSV"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000004">
        <property type="entry name" value="ragulator complex protein LAMTOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14675" checksum="7C3B83758BA77AA8" modified="2019-04-10" version="1">MLCASDLNGVVSSAVGDGVLMVLLLDASGNAIATAFAGSAAQKDMMYAPVVAATANMWRAYARSDLAVNKFNLELETESLEQMMVIFPDKKICAMSVADTAVVSLVSVDNSVTEGFLKLKTAALQRKLDRLLRPVMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIU6</accession>
    <accession>E9BRZ9</accession>
    <name>A0A3Q8IIU6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Short chain dehydrogenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Short_chain_dehydrogenase_putative/GeneDB:LmjF.35.1220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_0405</name>
        <name evidence="8" type="ORF">CGC21_6145</name>
        <name evidence="7" type="ORF">LDBPK_351230</name>
        <name evidence="5" type="ORF">LdCL_350017100</name>
        <name evidence="6" type="ORF">LDHU3_35.1630</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864708.1">
        <property type="nucleotide sequence ID" value="XM_003864660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIU6"/>
    <dbReference type="SMR" id="A0A3Q8IIU6"/>
    <dbReference type="GeneID" id="13387588"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1630"/>
    <dbReference type="OMA" id="MLTTQYA"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001215">
        <property type="entry name" value="Putative short chain dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU82921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="233" mass="24805" checksum="10F16FD1AF042E73" modified="2019-04-10" version="1">MKSVFITGGNRGIGLETARQMGKLGYYVIISCRDEEKAKTAIEKVSAEGVKADYVIMDVVDESSVAKAAAEVSKKVNGVLDALINNAGYAAPSGDMSRVNLDEMRRCYEVNVIGTVCVTNHFLEMVKKSSAGRIVNVGSIMGSCQLEVAALSHTPYNCSKAALNMYTVNLASSLKDTNVKANCAHPGWVKTDMGGAKAPLEVTEGAETSVYLATLPADGPTGGFFHKCDRLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ41</accession>
    <accession>E9BSD9</accession>
    <name>A0A3Q8IJ41_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_6835</name>
        <name evidence="4" type="ORF">LDBPK_352690</name>
        <name evidence="3" type="ORF">LdCL_350031800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864848.1">
        <property type="nucleotide sequence ID" value="XM_003864800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ41"/>
    <dbReference type="GeneID" id="13387726"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3440"/>
    <dbReference type="OMA" id="MRQVGWI"/>
    <dbReference type="OrthoDB" id="277426at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="267" mass="29389" checksum="7B6E99B1B53618CA" modified="2019-04-10" version="1">MALDKSRISILSSTKVDGEKLSSVGDTMDSLIPASRRLELKREKRCPLCCVAYGVLISSVAVFCITACGTAVSIFAESRINYTVNGAMRQTAWIAFPGILAGATLHYFMAEAMWSSKHNSWGQAWTKAIIANVGLWTGAICIGTLGWRKGLPLISAGRRLYHRYPIPSEPLEARLLRSSREFFTGMGTTYWLSGVASGHLGFVTCVSFCVSANRPYFMMAPHGGYAYRCMPPWRRQQLQAMALGSDSADQPTKPPPQEQTRKQPPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ57</accession>
    <name>A0A3Q8IJ57_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome recycling factor family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ribosome recycling factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_35040</name>
        <name evidence="4" type="ORF">LdCL_300009600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ57"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0630"/>
    <dbReference type="OrthoDB" id="278167at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.20:FF:000008">
        <property type="entry name" value="Ribosome_recycling_factor_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000029">
        <property type="entry name" value="Ribosome_recycling_factor_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="3">
        <location>
            <begin position="129"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="288" mass="31521" checksum="332CCA6CA26AA9F9" modified="2019-04-10" version="1">MLRCITHSRLPGSILLSGAAVPRLSQVTCTSTWASSSSLTTAKALWCSATAPLRKDIRKNDRGDARRLTFEERAERRMGKTKDQRESREQLAQEAQVMVSEDFPEELEAIYAKTSEKANISAMKVLNMAKCLELLEVEVAGGHTVLLVKVAQVVKTSTTTIEITPNSASFGNTILQRVSRFDSALQVSKEGTKIRVVIPPITTARRDKTVAEVNNLISTFRQRVKQSRTKAVKVLQDAGLADGVQQELTALVDSTANAFVEEKAAELELLSEEVMTMGIDESDVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ66</accession>
    <accession>E9BRX9</accession>
    <name>A0A3Q8IJ66_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_351030</name>
        <name evidence="11" type="ORF">LdCL_350015100</name>
        <name evidence="12" type="ORF">LDHU3_35.1290</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864688.1">
        <property type="nucleotide sequence ID" value="XM_003864640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ66"/>
    <dbReference type="SMR" id="A0A3Q8IJ66"/>
    <dbReference type="GeneID" id="13387568"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1290"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="10256129at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000635">
        <property type="entry name" value="Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ38008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39780" checksum="7098FBC2D0930A76" modified="2019-04-10" version="1">MNVELRVGNRYRIGQKIGSGSFGEIFRGTNIQTGDPVAIKLEQVKTRHPQLTYESRFYRILGSGGGAVGIPMMFYHGVEGEFNVMVIELLGPSLEDLFSFCGRRLSLKTTLMLADQMISRIEFVHSKSVLHRDIKPDNFLMGTGKKGHHVYIIDFGLAKKYRDPRTHAHIPYKEGKSLTGTARYCSINTHMGVEQGRRDDMEGIGYILMYFLRGSLPWQGLKAHTKQEKYNRISERKQTTPVELLCKGFPSEFAAYMNYVRALRFEDKPDYSYLKRMFRDLFVREGYHVDYVFDWTLKRIHESLQEQQSFPGGSNGGGAAGNGSPVNQSPAQGGNGGAPNSANNQESGAQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJU3</accession>
    <name>A0A3Q8IJU3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LdCL_350049400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350049400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5860"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000003">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000030">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="17">
        <location>
            <begin position="1642"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="686"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1311"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1315"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2302" mass="258837" checksum="7E12EEBBE45D64A0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJX3</accession>
    <name>A0A3Q8IJX3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VHS domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360060900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJX3"/>
    <dbReference type="SMR" id="A0A3Q8IJX3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360060900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7190"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03561">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000066">
        <property type="entry name" value="VHS domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898:SF4">
        <property type="entry name" value="TARGET OF MYB PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45898">
        <property type="entry name" value="TOM1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="518" mass="55619" checksum="93F05707B0328190" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK78</accession>
    <name>A0A3Q8IK78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain family cysteine protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_360013300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK78"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1100"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="393"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1071" mass="115856" checksum="3A4D625506086CCC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKW0</accession>
    <accession>E9BU11</accession>
    <name>A0A3Q8IKW0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_28470</name>
        <name evidence="13" type="ORF">CGC21_13790</name>
        <name evidence="14" type="ORF">CGC21_13795</name>
        <name evidence="15" type="ORF">CGC21_13800</name>
        <name evidence="11" type="ORF">LDBPK_363020</name>
        <name evidence="7" type="ORF">LdCL_360036500</name>
        <name evidence="8" type="ORF">LdCL_360036600</name>
        <name evidence="9" type="ORF">LDHU3_36.4170</name>
        <name evidence="10" type="ORF">LDHU3_36.4180</name>
    </gene>
    <organism evidence="7 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="7 17" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865417.1">
        <property type="nucleotide sequence ID" value="XM_003865369.1"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="Z=1-137"/>
    </dbReference>
    <dbReference type="PDBsum" id="6AZ1"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKW0"/>
    <dbReference type="EMDB" id="EMD-7024"/>
    <dbReference type="SMR" id="A0A3Q8IKW0"/>
    <dbReference type="GeneID" id="13388302"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4180"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="260791at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5434875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP48408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP48409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP48410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6AZ1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15770" checksum="BA9692933A2E5359" modified="2019-04-10" version="1">MVFQKKKAEVCIRTSQFKVNKLLNRKQFIVEVNHPHWCGTVPTQLIRKKLATLYKVPDASQVSLFGFKTKFGGGKTTGFGLIYDDLASLKRFEPNYRKTRMGFGKARLPARKSVKERRNRNKKLRGKAKGKQVAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL19</accession>
    <name>A0A3Q8IL19_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360041700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL19"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360041700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4750"/>
    <dbReference type="OrthoDB" id="275999at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17556" checksum="07C63ADEB72678BC" modified="2019-04-10" version="1">MLRRSADRYMKPFLHAFSPGARASEKGMLYRNSYMNAHAQVASIQSTHRTRRERTIFLLLLLPDQVFMCIIVFATGCVAVAVLFRQQPFSTNLNKDRWLSGGMNPHEQYERNATMSQIFEMHKEAIDNTRAELTRPQAFSAPSGYHSPSGVYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IRA6</accession>
    <name>A0A3Q8IRA6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290017700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IRA6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1740"/>
    <dbReference type="OrthoDB" id="248349at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="370" mass="40167" checksum="15CB19D81BBB8D88" modified="2019-04-10" version="1">MITATADAGSAAKAAATPPARLFDCLDAASKERVTMLLSHYQVLLPVEQASFMQELERYNQEQQTTALARNKAGEVWIRYTNPRLQAVQARDPAYVQRLISHTAASRGSKGDEASEEATAPCSLEDLVHTRGMFGEPEGVPIRVGKMSLYEKLHQNMRNRRSTAGGSLTNTTTSSIPTAADPGHGAARVSVPFGPFAEAEAKPAEGKREVGDNASPKTSAQSESGERAVALACADTFPSHTSSVRPSAPYRNNAYQAVRLAMNSPGYTATTQPTSVAELQTPLDGVKPVLNTTAFPITEEELRDWFDELDVHGRGVLSVEEFQRYMQSLERDLGVPTEYATLELDGAPLAKDGWLNFEAFSYLVLRFARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IT45</accession>
    <accession>E9BNI3</accession>
    <name>A0A3Q8IT45_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RNA_binding_protein_putative/GeneDB:LmjF.32.0750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_33720</name>
        <name evidence="8" type="ORF">CGC21_19965</name>
        <name evidence="7" type="ORF">LDBPK_320790</name>
        <name evidence="5" type="ORF">LdCL_320013500</name>
        <name evidence="6" type="ORF">LDHU3_32.0990</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="Structure" volume="25" first="1785" last="1794.e3">
            <title>The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.</title>
            <authorList>
                <person name="Brito Querido J."/>
                <person name="Mancera-Martinez E."/>
                <person name="Vicens Q."/>
                <person name="Bochler A."/>
                <person name="Chicher J."/>
                <person name="Simonetti A."/>
                <person name="Hashem Y."/>
            </authorList>
            <dbReference type="PubMed" id="29107485"/>
            <dbReference type="DOI" id="10.1016/j.str.2017.09.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="5 11" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863497.1">
        <property type="nucleotide sequence ID" value="XM_003863449.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OSG">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="h=1-235"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OSG"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IT45"/>
    <dbReference type="SMR" id="A0A3Q8IT45"/>
    <dbReference type="GeneID" id="13390309"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0990"/>
    <dbReference type="OMA" id="QRYAIVF"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21613">
        <property type="entry name" value="RRM1_KSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21614">
        <property type="entry name" value="RRM2_KSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="DisProt" id="DP04432"/>
    <dbReference type="FunFam" id="3.30.70.330:FF:000922">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF55">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5432836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP43594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP47089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5OSG"/>
        </source>
    </evidence>
    <sequence length="235" mass="25209" checksum="60FBF28275B9705A" modified="2019-04-10" version="1">MPAKAAAKPVKPATKAAPKPANKAPAPKAAAAKPVAKAAPKAAAPAVRPASGSSNGVYVKNWGTGSVADATNVFSAAGKVVKVQLRRQRYALVFFENSAAVKKAIDLFNEKEVLGQTVLVVPAKASPKPDAHENSSCVFVSPIFRPSTTKAQVMELFAGVKVQRLRMYRQNFAYAYLDSPAAAKKFVEEKNGTAFRGHTLRVALSARSLEKLRARQEVANVVIAAHRHYKVHERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IV20</accession>
    <name>A0A3Q8IV20_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350012700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IV20"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350012700"/>
    <dbReference type="OrthoDB" id="267260at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25681" checksum="40882B1BD0A4B798" modified="2019-04-10" version="1">MQRQRQDEEELICAIANINEQSLGRSHPRQSPHPGTTLTGSVLSSWQQQQQQQQQGAEDRPSYEQVLIERAEVFAALRQFKEKGDVIVHKLYSTVKAQQEQVLELGATVEALKKASKRLKDALGNGGGAAGGSLGSGAGAAATAGSFTRVPDTVAELQEKIITQRRVIEQMGQLMQNADRMLLAMRARVEAVEQRATGASVECRRLPPLPLTSGSGTSNASTPRQAPLGGDGDVATVSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IV65</accession>
    <accession>E9BS43</accession>
    <name>A0A3Q8IV65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_6350</name>
        <name evidence="4" type="ORF">LDBPK_351680</name>
        <name evidence="3" type="ORF">LdCL_350021700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864752.1">
        <property type="nucleotide sequence ID" value="XM_003864704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IV65"/>
    <dbReference type="GeneID" id="13387632"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2220"/>
    <dbReference type="OMA" id="IETRIVW"/>
    <dbReference type="OrthoDB" id="270285at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="278" mass="31437" checksum="B4E98011E3BBD880" modified="2019-04-10" version="1">MGLQIIEGLGGSSRCVTLLTFTIHFLHSLFSVVNFLSWVQTPGSRLTHSTQMAYLSLTVVCCLFYFFGASVFYMWAWRFPEPEEVAKRRRVYGVGIHLFFCDLPIFIIETRIVWRVQFPAAIMGFNYVLTCVSLSYSTLRVWFFLMVRLIKFHLPTARSIGANYTTRTSLAARRAMDESDYTGHGGATPPSAAAGHTIFLNRNAGLHSDDRVSATRLYYTPDTDRDRRDVYYGPSPSRYYSSSSDDLSISQRPSQHGCRRSPGANVYSPQSAAPPFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H563</accession>
    <name>A0A3S5H563_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_030013600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0930"/>
    <dbReference type="OrthoDB" id="267786at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472:SF28">
        <property type="entry name" value="BROMO AND FHA DOMAIN-CONTAINING PROTEIN DDB_G0267958"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33472">
        <property type="entry name" value="OS01G0106600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1848"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2072"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2159"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1603"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1800"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2073"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2101"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2159"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2234"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2297"/>
            <end position="2308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2322" mass="244863" checksum="D47599198FB71C71" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5H3</accession>
    <accession>E9B8C4</accession>
    <name>A0A3S5H5H3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_24440</name>
        <name evidence="6" type="ORF">LDBPK_050340</name>
        <name evidence="4" type="ORF">LdCL_050008400</name>
        <name evidence="5" type="ORF">LDHU3_05.0390</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858221.1">
        <property type="nucleotide sequence ID" value="XM_003858173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5H3"/>
    <dbReference type="SMR" id="A0A3S5H5H3"/>
    <dbReference type="GeneID" id="13391354"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0390"/>
    <dbReference type="OMA" id="QHQRVFN"/>
    <dbReference type="OrthoDB" id="270876at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5427291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP51867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="371" mass="40693" checksum="0F4DFD37C36AD917" modified="2019-04-10" version="1">MLKSSIVLLRRGKPRPRAGMFPEKYRRVPALLKPQQGGQQYFNEFLIRSANDALEAQQQGYGSAFRAGGSGAARTLADANATAAGGSNGGEISSVHPRLPQADIDGVLQRSRAETIQEELKQLVAQDGFVSQRGFNERMWYEQEHHRLRTHGDGVEASPSEAAATTAASSSTAEAGSATGEGRVLPERILGDDYFQSKFGYSLLKGRSPDASAAADIVKAYAQLDLWGEMPTYSRDFVFLYLVSRRRNTYAVAYDYDGKRLLPTYTAGNRGLKGGDRGFRGDGSTDNGHQVTSMYLNDLLPKIREARAASGRPLGRGEKIDLVVRVMGFYNGRQGAVRAVQDRSADFRVRYLEDVTPFPLNGPKMPRGVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5I7</accession>
    <name>A0A3S5H5I7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_050011300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5I7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0700"/>
    <dbReference type="OrthoDB" id="267927at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="892" mass="92599" checksum="C9389476F66C5FF7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5L5</accession>
    <accession>E9B8J5</accession>
    <name>A0A3S5H5L5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_9730</name>
        <name evidence="4" type="ORF">LDBPK_051050</name>
        <name evidence="3" type="ORF">LdCL_050015800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858292.1">
        <property type="nucleotide sequence ID" value="XM_003858244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5L5"/>
    <dbReference type="GeneID" id="13391334"/>
    <dbReference type="KEGG" id="ldo:LDBPK_051050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_051050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050015800"/>
    <dbReference type="OMA" id="RTCFYEK"/>
    <dbReference type="OrthoDB" id="259289at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="443" mass="50820" checksum="AABD4683FDD5B74E" modified="2019-04-10" version="1">MFHTSRLAVPRLATKTSALLTRPGKAEKSVAPPNPEARTENSTVSGVTERTTAPLQPPIIDSTKEGRTHILPQKVLKELLNSVSAGQQNFLFGSDKDAGDPTVGVLRATGSFFESINTAYEGRMLQEQQVEVENFVAKRRIHYMQRLNEETEEFRREQKEIHDEIQRLEAEKYKNDLNNDVIQFTKARETEYEARLHADVEKYHNALLAYRARAKKSDQLGANGETPLKQLNMNVIEIMQEMEMDDTLRDFGDAAGIGNDLSDQDIRSYVVQRTCFYEKVVQDEVHEFTKRRKSFYEDLLEARAVRHAAKVRADTEKFHSQRQSYYDERLTADGSWMAKCFQEHYNRCFLQSYARRAWIEHRRYQATLEGIKLFTENGEKVPAISNPADISISTLNAEIPLSTILDMYESENMAEVTRDVFLKAARRVAADYAPYSVDERPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5P0</accession>
    <name>A0A3S5H5P0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LdCL_060007700</name>
        <name evidence="19" type="ORF">LDHU3_06.0320</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0320"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000004">
        <property type="entry name" value="5'-3' exonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.750:FF:000003">
        <property type="entry name" value="Putative 5'-3' exonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF75">
        <property type="entry name" value="EXONUCLEASE XRNA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="14">
        <location>
            <begin position="406"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="16">
        <location>
            <begin position="620"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="17">
        <location>
            <begin position="992"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="15">
        <location>
            <begin position="1128"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1245"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1402"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1257"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1296"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1363"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1418"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1430"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU76056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAC5427407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1499" mass="167035" checksum="5AF78FEFDCFED942" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5V6</accession>
    <accession>E9B8Z9</accession>
    <name>A0A3S5H5V6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_070030</name>
        <name evidence="13" type="ORF">LdCL_070005200</name>
        <name evidence="14" type="ORF">LDHU3_07.0060</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858445.1">
        <property type="nucleotide sequence ID" value="XM_003858397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5V6"/>
    <dbReference type="SMR" id="A0A3S5H5V6"/>
    <dbReference type="GeneID" id="13391775"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0060"/>
    <dbReference type="OMA" id="SVEWCSM"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000333">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU76170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5427520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ31722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="299" mass="33746" checksum="5A979873896856C8" modified="2019-04-10" version="1">MPVVRARKARLDHGSKRSISRFLVSEAAIGKLVKDVSTGTDAAHPVTPRELGSGLPHDPIHLPLRRTPNGSGCYHCTTEECCCVEFEKILSNAYAKVSKKRVVEVSGSRQLCAKSLLTPFVTRLVRLMNITEKDTFYDFGCGNGSVLFQVAFMTGAKCVGVEISEHNADVAREAWQLLRQVLEKKYDRPMPRVEIITADLAELLSTPTYFDEEEGQTAILISNLLFPKPLTHFLSERLRSAPVGTRILCFDDLYPHARSVAPYRDPGAFELFEMKDYLWQEMSVEWCSMEGRFFIHTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H725</accession>
    <accession>E9BDK8</accession>
    <name>A0A3S5H725_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycogen synthase kinase 3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_39580</name>
        <name evidence="10" type="ORF">CGC21_3385</name>
        <name evidence="9" type="ORF">LDBPK_180270</name>
        <name evidence="8" type="ORF">LdCL_180007600</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860041.1">
        <property type="nucleotide sequence ID" value="XM_003859993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H725"/>
    <dbReference type="SMR" id="A0A3S5H725"/>
    <dbReference type="GeneID" id="13393480"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0340"/>
    <dbReference type="OMA" id="KMNDSVC"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000731">
        <property type="entry name" value="Glycogen synthase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP55315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="355" mass="40737" checksum="BD94054F3EC4A499" modified="2019-04-10" version="1">MSLNAADAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTSVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFCDHSLKDAKEAYDLLSALLQYLPEDRMKPYEALCHPYFDELHDSATKLPNNKDLPEDLFRFLPSEIEVMSEAQKAKLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7D9</accession>
    <name>A0A3S5H7D9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta galactofuranosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_250005000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7D9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0020"/>
    <dbReference type="OrthoDB" id="10267535at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179:SF12">
        <property type="entry name" value="GALACTOFURANOSYLTRANSFERASE GLFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43179">
        <property type="entry name" value="RHAMNOSYLTRANSFERASE WBBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="434" mass="50926" checksum="837F5AED935592E7" modified="2019-04-10" version="1">MAPPRWHHDRRRMAIFVRVGLYTLLFLMGYIVPLIIFYNRSRADTFEDTPRSGEAFISDENFFHCIAERLSYKEQHPARIPYVLIPVTMDYQDIKQLFCNITVPMTYIMFINNGMFRPLRSLLDRLAVDLRDYVDQNLFIIHHPENIGYASAVNEGLRHALNFSVAKVPWVFITNADVRFAPGLIDEFVSQANEKTQGQLERIRRLDQEIIAEARTLRNVPNPRFAFRSSQHPIITASSLPYRIRTMPPEEMKKQFADTYGIFYTDHKDFMATFALSRLAIATVGFFDENYYPAYGEDHDYVWRMAALGYQKYFSEPGKFVHFENANLNVGGSARNRGIFKNTAYFLQSVKFGRMNYQPFRLPYRRAKWFPDGVTIYQDTGRNPLPFNGTIPLDMWVLDTDRRRSIWEIGENIRCHRDYKPYSMKLLDFPVDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7P6</accession>
    <name>A0A3S5H7P6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310014800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7P6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310014800"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11335" checksum="CCEB1893BB7AB07E" modified="2019-04-10" version="1">MFHQAAPPLQQPQTTYAYLPAPQPPLPTTTVVVSEGPYGYEQGLFPPSPPPRPGLLDVLLDLTHHHHHGNPPGPPGGFGGPGVFGGPPDGLGSFGGAPGRPGCQQHGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7Q6</accession>
    <accession>E9BN40</accession>
    <name>A0A3S5H7Q6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC21_10940</name>
        <name evidence="13" type="ORF">LDBPK_312700</name>
        <name evidence="12" type="ORF">LdCL_310035000</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863357.1">
        <property type="nucleotide sequence ID" value="XM_003863309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7Q6"/>
    <dbReference type="SMR" id="A0A3S5H7Q6"/>
    <dbReference type="GeneID" id="13389689"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4780"/>
    <dbReference type="OMA" id="YLVMESR"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU81477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ36668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="365" mass="40758" checksum="56E8A28F3CCAD806" modified="2019-04-10" version="1">MVGLSKVEVIIGKLLLNPAHNTAAPKRDANSPLSSFARQSRLKAFQAETAAAAAAGAPKADSANRTGHTRGRSSSSISDPREFATGEMTEEEVVYLVMESRKLFMSQPMLIEIEAPVNVCGDVHGQYHDLLRLFELGGYPPDSNYIFLGDYVDRGEQSLETVCLLLAYKLNFPNNFFLLRGNHESSSINRIYGFFDECKRRYSVKLWKLFTDTFNCMPVAGLIDGRILCMHGGLSPELHNLDQIRRILRPSDVPDSGLICDLLWSDPADDPIIGFGENDRGVSWTFGENVVENITQALDLDLICRAHQVAEEGYKFFAKRKLLTVFSAPNYCGEFNNYGAFLCVDENLMCSVKQLVPLFEVDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7Z3</accession>
    <name>A0A3S5H7Z3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350026200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7Z3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2710"/>
    <dbReference type="OrthoDB" id="272613at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="723" mass="80336" checksum="E671B64F6167511A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP13</accession>
    <name>A0A3S7WP13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphate carrier protein, mitochondrial-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_050007900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0350"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000350">
        <property type="entry name" value="Phosphate carrier protein, mitochondrial-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF28">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="131"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="257"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="361"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU75935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="485" mass="51254" checksum="72DBFF918BCD23A8" modified="2019-05-08" version="1">MFPVPAGFAVHNRNTGSNNSEGDGHGSRVDERSTVLGLVAGVGGGSMTEADVVSAVITTSLLPPGGVNGVGAASFVSPIVGSRDRVCFQHFLIAAAASALAAVLVVTYVWQSTSAFNIDPVTGKVRPHSFQYFVYCFVGGIAAGMVHLVVAPIDILKCRVQVGEYRSFKDGFVHLFRVEAGGSVYRALPLFFRGWLPMLWGYCIQGSIKFSLYEIVKYVLLIAFLEPSVEAKAAAAAAGGVANSLASSSAAHVSGVYQFFVFLFSSCLAEVVADLGLAPWEAVKIRMQTSPSFPVHLRSALPRMWETEGLHGFYRGLVPLWGRQVPYTMMKFSSFEFVVVGLQSLFHSLGVMDAAEPGVLGKLVVSLLAGVLAGLLCGVVSHPADTVLSKMSQRSSAPTSSAVPALANTLADATCGSVGHGRAGAAHGGAMHGVLEVMHELGWRGMWKGLAPRLLMVVSLTALQWVTYDGFKVWAGLPTSGDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP55</accession>
    <name>A0A3S7WP55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinesin, putative</fullName>
            <ecNumber evidence="6">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_050011400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="6"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP55"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0710"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF67">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="9"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1225" mass="130677" checksum="107DD47289F31B72" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPA9</accession>
    <accession>E9B8L2</accession>
    <name>A0A3S7WPA9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_060010</name>
        <name evidence="11" type="ORF">LdCL_060005000</name>
        <name evidence="12" type="ORF">LDHU3_06.0020</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858309.1">
        <property type="nucleotide sequence ID" value="XM_003858261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPA9"/>
    <dbReference type="SMR" id="A0A3S7WPA9"/>
    <dbReference type="GeneID" id="13391774"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0020"/>
    <dbReference type="OMA" id="NTEHAGR"/>
    <dbReference type="OrthoDB" id="257350at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000058">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5427381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ31585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11424" checksum="7B502B40C147AA30" modified="2019-05-08" version="1">MAKGKRSADAKSSQKRQKKVLRDNIRGITRGCVRRMARRGGVKRISSDVYEEVRRVLKAYLEDIVRCSTAYTEYARKKTVTACDVVNALRKKGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPE9</accession>
    <name>A0A3S7WPE9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_060009700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPE9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0560"/>
    <dbReference type="OrthoDB" id="266971at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="994" mass="104398" checksum="9C3C3648EB7B18A9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPK3</accession>
    <accession>E9B8V0</accession>
    <name>A0A3S7WPK3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine N-methyltransferase, type III, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Arginine_N-methyltransferase_type_III_putative/Ge neDB:LmjF.06.0870</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Methyltransferase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_24145</name>
        <name evidence="6" type="ORF">LDBPK_060900</name>
        <name evidence="4" type="ORF">LdCL_060014100</name>
        <name evidence="5" type="ORF">LDHU3_06.1040</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858396.1">
        <property type="nucleotide sequence ID" value="XM_003858348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPK3"/>
    <dbReference type="SMR" id="A0A3S7WPK3"/>
    <dbReference type="GeneID" id="13391752"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1040"/>
    <dbReference type="OMA" id="AHAMLFY"/>
    <dbReference type="OrthoDB" id="412876at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000027">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000433">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5427471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="438" mass="48305" checksum="35B5A74B412F4CC2" modified="2019-05-08" version="1">MPSKKTSAGGAKKNTSTAATRSNRHAHPQADIGFLPPGAKYPAEASWNHHEHQQRNSASYGKQEGHDRNNDFDYRFEQHIFVPSRLRRVPAALVEAVNDFHYAMMNDLPRNEFYYNMLKKHIVPGESGVLEIGAGSGLLSMMAAKLNAKWVVAVEGSSEMASLARSNIATNGLQDKVKVLNMLSTELTPRDLPEPPSILVSEIFGTLLLGESALDYIADARQRLLPKTAKILPQHGVQYAVPIECETLGQICAVSSWNGIDLSHVMALQDTTSVVFTKQYGFRMSSVPFRRLADPIPLLTIDFAETKRSTFKKVFPVEVPATASGTAHAWLFYWISTDGEEVMSTAPEDTLHNFSRDMQWGQALQLIDAGTNSHTPTALSMSTGESYKFECALSSDRVVMSLKYTGSSSAAALLKADANEAEKRRETESEQQRRPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPW7</accession>
    <accession>E9B970</accession>
    <name>A0A3S7WPW7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Centrin_putative/GeneDB:LmjF.07.0710</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">EF hand family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_1170</name>
        <name evidence="11" type="ORF">CGC21_10410</name>
        <name evidence="9" type="ORF">LDBPK_070790</name>
        <name evidence="7" type="ORF">LdCL_070012700</name>
        <name evidence="8" type="ORF">LDHU3_07.0960</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000059">
        <property type="protein sequence ID" value="TPP45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858516.1">
        <property type="nucleotide sequence ID" value="XM_003858468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPW7"/>
    <dbReference type="SMR" id="A0A3S7WPW7"/>
    <dbReference type="GeneID" id="13391812"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0960"/>
    <dbReference type="OMA" id="HPGLTQQ"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5427593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP45292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP52491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="187" mass="20620" checksum="5F47615FE0491894" modified="2019-05-08" version="1">MSIASTTPLRPSTSASNANAELSKDQLEEIREAFDLFDTDGSGTIDVRELRIAMRALGFEPRKEELQQLINSVTGGSGCEGTPARLSGAGNVNASSDVITFSQFVQIMKHKVSQRDSREEMLKAFVLFDTEGTGKISFQNLKRVAVELGENMTDAELQEMIDEADRDGDGEVSEEEFLRLMKKTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ88</accession>
    <name>A0A3S7WQ88_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_23160</name>
        <name evidence="2" type="ORF">LdCL_080011500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ88"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0720"/>
    <dbReference type="OrthoDB" id="265295at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP54964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="300" mass="31685" checksum="3728C76CD9800543" modified="2019-05-08" version="1">MVSGNTHLTLLRSSVVVGAVAAALCLGATAMLPIFRLNIDALNSSITQSLWTTDIYTPAGEKHIPVKKFVKDCSDLALAFQVAQVCTLVGIGALALAFLCSVLHMSSTFTRSSYRVRAVCGAPICLLLTVAIAAAGLNCYIMRAMYENNWCEKNTTGCMEATQSAMGVIGRPSILLNRGLPLRKMSKIQHSFLTPAVNMKFAVSREADIFATPLTKAAATGSTGGLFGDCNPFDGCISSFHNMGFTGAEGWQTTWAALAATVTGFFAETLVVIIGGRRSSEAGLGESAVALLQGEDERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU26</accession>
    <name>A0A3S7WU26_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome c family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Cytochrome c, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Cytochrome_c_putative/GeneDB:LmjF.16.1310/GeneDB: LmjF.16.1320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_36840</name>
        <name evidence="16" type="ORF">CGC20_36845</name>
        <name evidence="12" type="ORF">LdCL_160018900</name>
        <name evidence="13" type="ORF">LDHU3_16.1650</name>
        <name evidence="14" type="ORF">LDHU3_16.1660</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP41017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP41018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU26"/>
    <dbReference type="SMR" id="A0A3S7WU26"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1660"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000014">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5428996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5428997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP41017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP41018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="113" mass="12181" checksum="A259C0493A64CA4C" modified="2019-05-08" version="1">MPPKARAPLPPGDVERGEKLFKGRAAQCHTATKGGANGVGPNLFGIVHRPSGKVEGFTYSKANAESGVVWTPEVLDVYLENPKKFMPGTKMSFAGIKKPQERADVIAYLETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU28</accession>
    <accession>E9BCZ1</accession>
    <name>A0A3S7WU28_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Cytochrome c, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC21_24730</name>
        <name evidence="15" type="ORF">CGC21_24735</name>
        <name evidence="13" type="ORF">LDBPK_161390</name>
        <name evidence="12" type="ORF">LdCL_160018800</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859824.1">
        <property type="nucleotide sequence ID" value="XM_003859776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU28"/>
    <dbReference type="GeneID" id="13393154"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1650"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000014">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP51114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="113" mass="12151" checksum="5759D55C3A64CA56" modified="2019-05-08" version="1">MPPKARAPLPPGDVERGEKLFKGRAAQCHTATKGGANGVGPNLFGIVHRPSGKVEGFAYSKANAESGVVWTPEVLDVYLENPKKFMPGTKMSFAGIKKPQERADVIAYLETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUB2</accession>
    <accession>E9BD58</accession>
    <name>A0A3S7WUB2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_170370</name>
        <name evidence="2" type="ORF">LdCL_170009200</name>
        <name evidence="3" type="ORF">LDHU3_17.0640</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859891.1">
        <property type="nucleotide sequence ID" value="XM_003859843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUB2"/>
    <dbReference type="GeneID" id="13393310"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0640"/>
    <dbReference type="OMA" id="RELERCY"/>
    <dbReference type="OrthoDB" id="273809at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="330" mass="35770" checksum="8B4C2DDF036117DA" modified="2019-05-08" version="1">MMGGRRGPPLDARPQALFAYAQTVTDTPMPRWQPPQTAAMGAGDKGSCHATPLTKAGASRFNVVFRRSSGSRQQRAKREGALSVAHDVSYLYDKDNRECVLRCKAVGQAPNKIFMCMQRAHRGADWVVGTELNLCGFDILVEEVMELHCIPYEEAVDAADAADNSSEAGAGGDLITCCGTSAHTASAASYAQTLSTAASVDPGRGHTTHAQPRFSFLPRQTSQHFVTTTPSRATRDNGPSSPTPLEDEEASSICAPQKWPTLKMDSVPVGTALTAHHPTDPPPPAPRDERGVDGSVCPNSCPPHERRQRRRRRSVASLARELERCYPEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUL8</accession>
    <name>A0A3S7WUL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170018900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUL8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1780"/>
    <dbReference type="OrthoDB" id="267728at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="598" mass="63805" checksum="DF0537E7E58D3EE9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUW0</accession>
    <name>A0A3S7WUW0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_180010300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUW0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0680"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57705" checksum="7B663C9ED46BA1DC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV68</accession>
    <name>A0A3S7WV68_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Plasma membrane ATPase</fullName>
            <ecNumber evidence="15">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LdCL_180020400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="15"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV68"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1900"/>
    <dbReference type="OrthoDB" id="258404at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU78080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="974" mass="107289" checksum="B3B3157AECD5A3A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVW6</accession>
    <name>A0A3S7WVW6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 16">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CGC20_31985</name>
        <name evidence="21" type="ORF">CGC21_29720</name>
        <name evidence="18" type="ORF">LdCL_200006100</name>
        <name evidence="19" type="ORF">LDHU3_20.0130</name>
    </gene>
    <organism evidence="18 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 22">LdCL</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 17">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVW6"/>
    <dbReference type="SMR" id="A0A3S7WVW6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0130"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000007">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000011">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027250">
        <property type="entry name" value="Pgk_euglenozoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500126">
        <property type="entry name" value="Pgk_euglenozoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAC5429571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP45560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="417" mass="44929" checksum="CCF50659C18F7FD2" modified="2019-05-08" version="1">MSLVLKKSIDDATFRDKKVLIRVDFNVPVKNGKITNDFRIRSALPTIQKVLKEGGSCILMSHLGRPKGARMSDPRPEKGVRGYEEAASLRPVAARIAELLGQKVEFAPDCLDAAVYASKLKSGDVLLLENVRFYAEEGSKKEEERDAMAKVLASYADLYVSDAFGTAHRDSATMTGIPKVLGAGYAGYLMEKEINYFSRVLNNPPRPLVAIVGGAKVSDKIELLDNMLGRINYLVIGGAMAYTFQKAQGRKIGISMCEEDKLDLAKSLLKKAQERGVQVFLPVDHVCNKEFKAADSPLVTENVDVPDGYMALDIGPKTIHLYEEVIGRCKSAIWNGPMGVFEMPCYSKGTFAVAKAMGTGTQKSGLLSIIGGGDSASAAELSGEAKNMSHVSTGGGASLELLEGKTLPGVAILTDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVZ7</accession>
    <accession>E9BEQ1</accession>
    <name>A0A3S7WVZ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glutaredoxin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glutaredoxin_putative/GeneDB:LmjF.20.1010</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_31590</name>
        <name evidence="6" type="ORF">CGC21_29345</name>
        <name evidence="4" type="ORF">LDBPK_201020</name>
        <name evidence="2" type="ORF">LdCL_200014900</name>
        <name evidence="3" type="ORF">LDHU3_20.1260</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860444.1">
        <property type="nucleotide sequence ID" value="XM_003860396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVZ7"/>
    <dbReference type="SMR" id="A0A3S7WVZ7"/>
    <dbReference type="GeneID" id="13386227"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1260"/>
    <dbReference type="OMA" id="YACYELD"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02066">
        <property type="entry name" value="GRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000317">
        <property type="entry name" value="Glutaredoxin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="107" mass="12389" checksum="D4B8ADADF009FAA1" modified="2019-05-08" version="1">MNQALDPARAPQFLDSMLRRNRIVLISATYCQFSTKLKMLLIELKHRFVSLEIDIIPNGREVFQEVVARTGVHTVPQVFLNGKYLGGYDDLIALYHKRELSETLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWU5</accession>
    <accession>E9BFK6</accession>
    <name>A0A3S7WWU5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_34710</name>
        <name evidence="14" type="ORF">LDBPK_212210</name>
        <name evidence="13" type="ORF">LdCL_210027800</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860737.1">
        <property type="nucleotide sequence ID" value="XM_003860689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWU5"/>
    <dbReference type="SMR" id="A0A3S7WWU5"/>
    <dbReference type="GeneID" id="13386556"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2620"/>
    <dbReference type="OMA" id="YSPYEFR"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001288">
        <property type="entry name" value="Putative peroxin 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP49434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="464" mass="48100" checksum="C1811EC0BF25CF0E" modified="2019-05-08" version="1">MAAEVPAQPQAALEAPLPEPEQPSSSELDADTTVQSAIRFLQDSRVRRSPVESQIRFLKGKGVPDEQIKYALAKVGRTVTAEKIASVRAPPANAAPTGATATACTTPLSAQLKTARQNAPVTMTPGPQYTQTLFPHSPPPPQVERQTKTVDWRDVVIGAGAAMLSGFSAYKLFNRYSPYEFRRKTDKKSRLYRGSSSRPRSANIASSGSETDASSTPQRGCVPPLPPPPPMAAAAEPSVSAASPAALTEEVKRLQTELDEAKEALANERKKCADLAVSAAKIRADKQQLSRANDRLTQQIDGLKKDIERLEREKSSAVGEATQTTAEGAVAAAPGPPSTYFPSVTTEGEQARNSPEVTSVTSASAPNSDVVPVLPVVPSPEAPATATAAPAMPDPITEAVQVAPASAAAVAPAPELPPVVVAASTPYADAAAPVATVTEVAAPLLPIGGAEPPKAGDGTPMSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY77</accession>
    <name>A0A3S7WY77_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inositol polyphosphate phosphatase, putative</fullName>
            <ecNumber evidence="6">3.1.3.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_240013400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="6"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0970"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="290"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1741"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1786"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2293"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2340"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2419"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2615"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1741"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2615"/>
            <end position="2624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2739" mass="291493" checksum="BA6CA4CD36232332" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZC0</accession>
    <accession>E9BHV0</accession>
    <name>A0A3S7WZC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting 55 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Vacuolar_protein_sorting_55_putative/Pfam:PF04133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_26325</name>
        <name evidence="10" type="ORF">CGC21_8995</name>
        <name evidence="9" type="ORF">LDBPK_251960</name>
        <name evidence="7" type="ORF">LdCL_250025400</name>
        <name evidence="8" type="ORF">LDHU3_25.2430</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861526.1">
        <property type="nucleotide sequence ID" value="XM_003861478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZC0"/>
    <dbReference type="GeneID" id="13388772"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2430"/>
    <dbReference type="OMA" id="KKRNAWP"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP40801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP48846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="139" mass="14725" checksum="3ED5E7CD11BDD0FF" modified="2019-05-08" version="1">MSGLRQLIISAFFLVMGFLFLILGCTVVRKRNAWPLMSLALYCFAPVPFFLCGRGADSDDFIDFDDEPLDAFSTVGLFMGGVLLISGPGLAVVLYHTSVICGLALFFTLLSGVCFIAAGVSLTVADGGDGDDAADGYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZF0</accession>
    <accession>E9BHY0</accession>
    <name>A0A3S7WZF0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-2 like Rad60 SUMO-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ubiquitin-2 like Rad60 SUMO-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_9105</name>
        <name evidence="5" type="ORF">LDBPK_252260</name>
        <name evidence="4" type="ORF">LdCL_250028400</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861556.1">
        <property type="nucleotide sequence ID" value="XM_003861508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZF0"/>
    <dbReference type="SMR" id="A0A3S7WZF0"/>
    <dbReference type="GeneID" id="13388802"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2730"/>
    <dbReference type="OMA" id="DRHYWRA"/>
    <dbReference type="OrthoDB" id="259087at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600664" evidence="2">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP40823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="236" mass="27433" checksum="47FAE7523A0D3A6A" modified="2019-05-08" version="1">MRRSQALFLHSTAACLLSAGKLSQYEQEAYEAHRRFAESQTYPGPIRAATPGDTRFYMGSAETILQENERHYWRAVVDDPHVQHLVPLRIRFKTFIWVTSGWEQRMQVVQVMAQRDSTIAELMQQVRIENQSPYLCTSSFKLCIDGKDLDELKTLADYDIDEYSRIDAIEENDHLLHTEAEKLKDWNVDEMPEDVLLRSPYKEMAMQPQPNLAPRYEAKPKGYYGKNDYSGMKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZP2</accession>
    <accession>E9BI76</accession>
    <name>A0A3S7WZP2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_4875</name>
        <name evidence="15" type="ORF">CGC21_31710</name>
        <name evidence="14" type="ORF">LDBPK_260630</name>
        <name evidence="12" type="ORF">LdCL_260012000</name>
        <name evidence="13" type="ORF">LDHU3_26.0840</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP51958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861651.1">
        <property type="nucleotide sequence ID" value="XM_003861603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZP2"/>
    <dbReference type="SMR" id="A0A3S7WZP2"/>
    <dbReference type="GeneID" id="13388897"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0840"/>
    <dbReference type="OMA" id="FINEHAG"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000003">
        <property type="entry name" value="Protein disulfide isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600670" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="126"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5430902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP41111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP51958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="377" mass="40794" checksum="122A88AEC72E095E" modified="2019-05-08" version="1">MNRRLSVVLALALVVFVLAGSCSSEDPGAVMPGIVQMSKDNFDQLVGKDKAALVEFYAPWCGHCKSMAPEYAALGAAYEASTNAKDLLLIGKVDATEDSDLGKRFGVTGFPTILYFASGSLEPEKYKGGRTAEDFAKYLSSAVAGLRLTIPNEPQFAMELVHTNFDAVVKDPSKAVLVMFYAPWCGHCKALKPIYNKLAKVFSNDKDVVIARINADDAANRKIATEYAVSGFPTLYFFPKGADEKPVEYKNGRNLEDFLTFVNENAGKHRLANGDLSWEYGVIAELAEAVARVATSSGESSKAAVEAVKAVASTLTESEDAAYYIKAAERIAAKGPAYVESESARLKRTLGGPVAGDRRDNMVMRLNILTSIQKHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZU4</accession>
    <accession>E9BIF5</accession>
    <name>A0A3S7WZU4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32050</name>
        <name evidence="3" type="ORF">LDBPK_261430</name>
        <name evidence="2" type="ORF">LdCL_260019900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861730.1">
        <property type="nucleotide sequence ID" value="XM_003861682.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13388976"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1740"/>
    <dbReference type="OMA" id="CEGPFLP"/>
    <dbReference type="OrthoDB" id="244021at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1374" mass="149705" checksum="36DC36C25C6CC237" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZV8</accession>
    <accession>E9BIA3</accession>
    <name>A0A3S7WZV8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_31810</name>
        <name evidence="5" type="ORF">LDBPK_260910</name>
        <name evidence="4" type="ORF">LdCL_260014700</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861678.1">
        <property type="nucleotide sequence ID" value="XM_003861630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZV8"/>
    <dbReference type="GeneID" id="13388924"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1160"/>
    <dbReference type="OMA" id="QFAVVNQ"/>
    <dbReference type="OrthoDB" id="18010at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000181">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP41131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="843" mass="92826" checksum="AE5BF8791A2F8FD2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1E1</accession>
    <name>A0A3S7X1E1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280016900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1E1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1550"/>
    <dbReference type="OrthoDB" id="271020at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="519" mass="57856" checksum="F78E675AFB35A8AF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1H9</accession>
    <accession>E9BJK6</accession>
    <name>A0A3S7X1H9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_22150</name>
        <name evidence="12" type="ORF">LDBPK_281350</name>
        <name evidence="11" type="ORF">LdCL_280018100</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862234.1">
        <property type="nucleotide sequence ID" value="XM_003862186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1H9"/>
    <dbReference type="GeneID" id="13386970"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1710"/>
    <dbReference type="OMA" id="CAPVNRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000067">
        <property type="entry name" value="Putative p450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="65"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="258"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP54271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="645" mass="72366" checksum="505F2473B68B63C9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1Q3</accession>
    <name>A0A3S7X1Q3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_280025100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1Q3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2630"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="278"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="457" mass="52134" checksum="1B0130A814854899" modified="2019-05-08" version="1">MSLSTHRPVKGITYGVVCPVCCNPMDFECISERMYGVRCPTCNAMIDLRNPAETLPDTDTGVYEGDTQRIKVVHYSAEVEPSTGMSASAQVNNLLSSVEAEKRKIMPTVMTGETKQAFSAQRQQALAQKFSLFFPVTHAIEYVVFGKKPYAKIGHVRIFRKRIPFYGYVNICAPQTTTSYSAPCSFTFLFIIPVRWLWAQLELEWIARYYHAELVLFFLFYTLLFRLAYSDPGYVKPGYMDDEGGDTAAAAAAEEMTLRDIERNQRESLWEDVNGVPMERKWCSTCNMHRPVRAAHCYICGLCCYDHDHHCGVLGICVGRRRVEMFSTFVSVATMMCALPTMTIICALWTHWEKFTAALLAVAFFLVVMLMPLSILLTMTAVSMWQSITQEASTRERIQHVYAHKRNPYNRGFFKNLYYHLVQRRVAASLFDDDFVKRCALRVQERELGTGVTVTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3B2</accession>
    <name>A0A3S7X3B2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300021100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2060"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001372">
        <property type="entry name" value="eIF-2 alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000704">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="548"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="813"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1296" mass="140797" checksum="C0C3451BA0423242" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X444</accession>
    <name>A0A3S7X444_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_310007300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X444"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0280"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000006">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF7">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="4">
        <location>
            <begin position="136"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="521" mass="56992" checksum="DD188D97ECAEE466" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6S0</accession>
    <accession>E9BQ85</accession>
    <name>A0A3S7X6S0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)/RNA_recognition_motif_(A.k.a._RRM_RBD_or_RNP_domain)_p utative/Pfam:PF00076/Pfam:PF14259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_10695</name>
        <name evidence="6" type="ORF">CGC21_37865</name>
        <name evidence="5" type="ORF">LDBPK_331540</name>
        <name evidence="3" type="ORF">LdCL_330022000</name>
        <name evidence="4" type="ORF">LDHU3_33.2310</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863980.1">
        <property type="nucleotide sequence ID" value="XM_003863932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6S0"/>
    <dbReference type="GeneID" id="13392375"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2310"/>
    <dbReference type="OMA" id="IGQPMGH"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000686">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP55545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="209" mass="23074" checksum="5A25B7C23A07E73B" modified="2019-05-08" version="1">MYMHPMGQPMGHPLVPPTIVSGAYQVNAIPVVQQQFVYTAQPMVAPQPMIQSVPAATPMYSVAPPRRQKNKGNAVLFVGQLNYDVTEKDVRDLFSYYGHVVNVVLLKDTKRNNGKGASTQPKNNKHVVGSSAFVTYPTTAEADLAIMSLHNRYCMDNRDKPVQVSYCQKTDIISDFGYRHALQLHSENPANPIPSITPTPSVAYAIKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X743</accession>
    <accession>E9BPN7</accession>
    <name>A0A3S7X743_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Tyrosine phosphatase family/Tyrosine phosphatase family C-terminal region containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_37160</name>
        <name evidence="2" type="ORF">LDBPK_332990</name>
        <name evidence="1" type="ORF">LdCL_330037000</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864123.1">
        <property type="nucleotide sequence ID" value="XM_003864075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X743"/>
    <dbReference type="SMR" id="A0A3S7X743"/>
    <dbReference type="GeneID" id="13392519"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330037000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4160"/>
    <dbReference type="OMA" id="ATAHRFM"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="258" mass="29348" checksum="EE8B348F54E927FE" modified="2019-05-08" version="1">MTSVIQRLRRVEVEGLENLRNLGGYHTNNSTKTKRRGVVYRSDQLFRIPACMAQRGLVDQLRIRHVYDLCDSTEVSEKRYSLLHMQHTSLPIDMSNANRFLKEGENLKQVATAHRFMQEIDREFVRSYALTVGLIIKGIIGSKASCDKAFLIHCTAGKDRTGWCCYVLLTLLDVTEKEKRADYLLTNTFVGIPADAWDYSGAEGMSEEAMAALWAAFNEYLDAALDELSKMGGIYKYAKSHMGLTDEDIDELRELMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7X4</accession>
    <name>A0A3S7X7X4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340026000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3150"/>
    <dbReference type="OrthoDB" id="263506at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1618"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1686"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1767"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1633"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1775"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1797"/>
            <end position="1815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1882" mass="205129" checksum="E100679F508C2B4D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X998</accession>
    <accession>E9BS69</accession>
    <name>A0A3S7X998_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">UBX domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">UBX_domain_containing_protein_putative/Pfam:PF007 89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_0065</name>
        <name evidence="7" type="ORF">CGC21_6500</name>
        <name evidence="6" type="ORF">LDBPK_351960</name>
        <name evidence="4" type="ORF">LdCL_350024800</name>
        <name evidence="5" type="ORF">LDHU3_35.2570</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864778.1">
        <property type="nucleotide sequence ID" value="XM_003864730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X998"/>
    <dbReference type="GeneID" id="13387657"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2570"/>
    <dbReference type="OMA" id="QISVRCP"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP46355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="332" mass="37473" checksum="8FDBB2532B15E688" modified="2019-05-08" version="1">MLVHEVETTYKLKVPFFQGTLEEAKRHAQQDSRYLVLYLHSPRHENTEAYLREVLATDEIIALLHESSVLFGVSVADTEGALLAEELGAHAFPFVAALVGNTVVLRLQGYHSRETFRREWRLCTDDWDGQLAEGVVLAAEREARERARIAEAEADSAMEAADRAILEELLRKDEEERRAAAEREAAARRAAEEFAAAERLKAEYKARQAAEEARQRALEEERQRQRESAKQAAKSKLHDEPSTDVATSETVQISVRCPSGKHYDRRFLRSDLVDQLAFFVLTLDEVADATDASTVRFVTGFPPAPLVWREGVTRFGDVKSLCPRAVVLLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA60</accession>
    <accession>E9BT76</accession>
    <name>A0A3S7XA60_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, putative</fullName>
            <ecNumber evidence="1">3.1.3.46</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">6-phosphofructo-2-kinase/fructose-26-bisphosphata s_putative/GeneDB:LmjF.36.0150</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Histidine phosphatase (Branch 1) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_29835</name>
        <name evidence="5" type="ORF">CGC21_12405</name>
        <name evidence="3" type="ORF">LDBPK_360160</name>
        <name evidence="1" type="ORF">LdCL_360006400</name>
        <name evidence="2" type="ORF">LDHU3_36.0230</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.46" evidence="1"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865134.1">
        <property type="nucleotide sequence ID" value="XM_003865086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA60"/>
    <dbReference type="SMR" id="A0A3S7XA60"/>
    <dbReference type="GeneID" id="13388019"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0230"/>
    <dbReference type="OMA" id="EAVHKPC"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000073">
        <property type="entry name" value="Fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF36">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="485" mass="55359" checksum="255A4595C47F6FEA" modified="2019-05-08" version="1">MVLVHLRASNVYDVGGMNEANTIDFRHMVGVEYHTQREVVRPPPSLTDTNANHVAMVSMGLYRFSNATSPVVIFVSSEERCSMPARFFCTRFVHYFRWIGESVQLFVASKSFQDHRPTPYATQRDTWLQENRRCVSAALDYFDSNPKLGFVATPVAVMFTDCDCADARAALVSLLPPERSFLIRHVRFAEEWESHRQNSYRFIDVSLQRQALRASRSSGSVVCSSLTSFLNSMLPTLYQLYSAEPLEGAPGETLKSFPPIFFTRHGQSEYNVEDRLGGDPDLTETGRIDAEDIAHFFERQVKTNVNLFDHRTTVWEEDGDFEVWCSQLRRTQRTAQPTADILSHGVLKPFKSLNEIHAGICEDMTNEEVKSLYPFIQRFRHTDKVGFRYPDGESYVDLVRRLTPLLNDLNNCMKCVVVVAHQAVLRTMLSFFGGRPVEEAVHVPCPQRTIWACTMNRLGEPQLAEIALSPRQTQDEGPEAHWQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB18</accession>
    <name>A0A3S7XB18_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360033900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3800"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="1611"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1250"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1464"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1478"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1735" mass="187493" checksum="AAA514FFA257D2A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB55</accession>
    <name>A0A3S7XB55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360040800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XB55"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360040800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4660"/>
    <dbReference type="OrthoDB" id="278656at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="853" mass="91984" checksum="8ED80BF28C7C10C9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJB5</accession>
    <name>A0A451EJB5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_010011200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0700"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000096">
        <property type="entry name" value="GTPase activating protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000044">
        <property type="entry name" value="TBC Kinase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="1785"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1819" mass="192888" checksum="0D27BAFF1274BB4A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJQ4</accession>
    <name>A0A451EJQ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_030010200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0530"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF23">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1825"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1825"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2044" mass="220202" checksum="B6FD3838E4B57C17" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8X8</accession>
    <accession>A0A3S5H5U2</accession>
    <name>E9B8X8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_061180</name>
        <name evidence="3" type="ORF">LdCL_060016900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858424.1">
        <property type="nucleotide sequence ID" value="XM_003858376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8X8"/>
    <dbReference type="GeneID" id="13391765"/>
    <dbReference type="KEGG" id="ldo:LDBPK_061180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_061180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1330"/>
    <dbReference type="OMA" id="QEPPMND"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="PhylomeDB" id="E9B8X8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="490"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="752" mass="79505" checksum="6B6EB804C95619E5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>E9B906</accession>
    <accession>A0A3S7WPU3</accession>
    <name>E9B906_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ring finger domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_070100</name>
        <name evidence="12" type="ORF">LdCL_070009000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858452.1">
        <property type="nucleotide sequence ID" value="XM_003858404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B906"/>
    <dbReference type="GeneID" id="13391848"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0480"/>
    <dbReference type="OMA" id="RFVWVIT"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="PhylomeDB" id="E9B906"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="11">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="803"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="7">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ31729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="922" mass="96402" checksum="739FED5CA8743A0B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAC0</accession>
    <accession>A0A3Q8I7R0</accession>
    <name>E9BAC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_100750</name>
        <name evidence="5" type="ORF">LdCL_100014300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858911.1">
        <property type="nucleotide sequence ID" value="XM_003858863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAC0"/>
    <dbReference type="GeneID" id="13389291"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1080"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="PhylomeDB" id="E9BAC0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001534">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001539">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="369"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="706"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="866"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="952" mass="102623" checksum="D2DA5CAF1A486DF8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBU7</accession>
    <accession>A0A3Q8I8S7</accession>
    <name>E9BBU7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_140620</name>
        <name evidence="2" type="ORF">LdCL_140011700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859433.1">
        <property type="nucleotide sequence ID" value="XM_003859385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBU7"/>
    <dbReference type="GeneID" id="13391103"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0850"/>
    <dbReference type="OMA" id="VEMIHQV"/>
    <dbReference type="OrthoDB" id="267634at2759"/>
    <dbReference type="PhylomeDB" id="E9BBU7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="463" mass="49988" checksum="09B8903BADADE98A" modified="2011-04-05" version="1">MRGLQLSHHAWRPRLSSAAAALRTSSSCTTSTSGAAVVITASRTNRATPAVYSTQRLYCTTQKKKGTSDAADSHSSTTAGISVGADATSDDAMDLIWSDMPDVHGPNHEATLASSPQEHRAATSTRAPKSSPHEESRASDASDTAASSPPAPPVSHVWVSMHNMPRNWLHEDIVEMIHQVAEHAGIATPEAPRLSESAAGREGEEGHTGEGTSSALNHMSSPFVRRLHIPFGRRTGLVYGSPKLLLTSRQLADYLIHQLSFDPDDFRSRVYFTHTKPEELPSGFQQQQQPHEGGVAGGDAANGDGVAQVTYTPIEETVEREQDEALRTLVLDRYLFAPDLLLDIAKSHQRRLVTKNEKVLLDAFVDGEEDSDDEEEDEDGGDVEDDDAVSGGSGADGDAESAAASLTRRQRPRHRHRATSKGGSDKRKSPLTRRVSAGTQKHLGRGSMHNMPIPKPYVAGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BC95</accession>
    <accession>A0A3S7WTD9</accession>
    <name>E9BC95_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecotin-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_150540</name>
        <name evidence="4" type="ORF">LdCL_150010500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I11 (ecotin) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859579.1">
        <property type="nucleotide sequence ID" value="XM_003859531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BC95"/>
    <dbReference type="GeneID" id="13393003"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0690"/>
    <dbReference type="OMA" id="PGRHENC"/>
    <dbReference type="OrthoDB" id="16445at2759"/>
    <dbReference type="PhylomeDB" id="E9BC95"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1230.10:FF:000002">
        <property type="entry name" value="Ecotin family (I11)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.550">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1230.10">
        <property type="entry name" value="Ecotin, trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027438">
        <property type="entry name" value="Ecotin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036198">
        <property type="entry name" value="Ecotin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005658">
        <property type="entry name" value="Prot_inh_ecotin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890:SF3">
        <property type="entry name" value="ECOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03974">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49772">
        <property type="entry name" value="Ecotin, trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="378" mass="41712" checksum="8B550C672BAF6B61" modified="2011-04-05" version="1">MPSLQDYHVPYPAAAPGQVRKVIYLPQQNPTVEQQHLRVQIIPGRHENCEDGRLYKLTGSVTEETLQGWGYSYYVVKLGDIYAAHRSSSDPARVTTFVALDENPVIAYNSKLPIVVYVPEGAELRYRIWTDDTSLVQSIQQQPEAPALPQPHLVPVTERQECPHELPRCGAPGEYVTQDCKTSMLSVEEVHRLSSSTPPLIPSAVRGSAHEAHAAPPLHSAELEERVCPVMEHLEVCPQNNGHEGREQPAEEASTLKRRSSSSSSSNPRHLSANEPSPSRPRLSSTEYWPQENSKTKRSPSATHKPRRSTDSATIEEAGVGAPKKNRSSSSSASSKKKAEDNVYEKTMKNFWNRARSDSPRKASASSKKSGNGSKADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJD6</accession>
    <accession>A0A3Q8IEF4</accession>
    <name>E9BJD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatidylinositol 3- and 4-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_272060</name>
        <name evidence="8" type="ORF">LdCL_270027900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862057.1">
        <property type="nucleotide sequence ID" value="XM_003862009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJD6"/>
    <dbReference type="GeneID" id="13386792"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3160"/>
    <dbReference type="OMA" id="KEMREEP"/>
    <dbReference type="OrthoDB" id="267514at2759"/>
    <dbReference type="PhylomeDB" id="E9BJD6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE-RELATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="414"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1008" mass="106020" checksum="910A80036F3BD5F8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMJ1</accession>
    <accession>A0A3S7X469</accession>
    <name>E9BMJ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FtsJ-like methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_310680</name>
        <name evidence="5" type="ORF">LdCL_310012500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863158.1">
        <property type="nucleotide sequence ID" value="XM_003863110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMJ1"/>
    <dbReference type="GeneID" id="13385879"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0980"/>
    <dbReference type="OMA" id="WNCLGCG"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="PhylomeDB" id="E9BMJ1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF19">
        <property type="entry name" value="METHYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="4">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="335" mass="36750" checksum="6C7A53A0F2C3E36F" modified="2011-04-05" version="1">MYRCQSALKLLEINDRYRIFHRLRPSTVVDLAAAPGGFAQVALELMHLPENAPQSVLPPMVVAVDQRSIDPMPGLVAVRGNILQHQRILQTVQGALSLMRAPTTSPPRVLSSAHTAPQTRCVDMVLHDGVSVVKGQRAFSVTYAQNHMALSTLLLASKLFQRRGLMPDLLTDAAPHRSSKPEGRISRSISAPRSSSAVLPVCFVSKVLQCDHSAQVLEATQALFRYVRIFKPVASRPESLERYVVATDFQLAAWQRLTAPHAPTVPRNWQWRHKHPRSTASVSLFSMPPALEDCGDAHHIAWNCLGCGRTCMGCQPCLQCGPYRPAVGAGARSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ93</accession>
    <accession>A0A3S7X6P1</accession>
    <name>E9BQ93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_331620</name>
        <name evidence="1" type="ORF">LdCL_330022800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863988.1">
        <property type="nucleotide sequence ID" value="XM_003863940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ93"/>
    <dbReference type="GeneID" id="13392383"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330022800"/>
    <dbReference type="OMA" id="HARACNS"/>
    <dbReference type="OrthoDB" id="10493984at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ93"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21446" checksum="51125C4986BFBC6F" modified="2011-04-05" version="1">MIPRHTNTEACAHARACNSIAQCPHSLYQCLFGLHIICSLDEGTREARTSVTVNRFVFLCSDCISIRVVASLGVYACFSVGVIQAVAYARNFPSFLAHLCGFSARSTSRVTLSGCLITDALILPPLLHHSHLLHCEHKSVSRALRSARDDALIFFFTLALTACSEGGIAEPQTRTHTHALLDADEGERSRSGASARSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BTD9</accession>
    <accession>A0A3S7XAD2</accession>
    <name>E9BTD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein family member, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_360800</name>
        <name evidence="7" type="ORF">LdCL_360012900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865196.1">
        <property type="nucleotide sequence ID" value="XM_003865148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BTD9"/>
    <dbReference type="GeneID" id="13388082"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1020"/>
    <dbReference type="OMA" id="RMQHCAH"/>
    <dbReference type="OrthoDB" id="277017at2759"/>
    <dbReference type="PhylomeDB" id="E9BTD9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562:SF2">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="542" mass="61077" checksum="B8730D6D440FC231" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BTN5</accession>
    <accession>A0A3S7XAQ0</accession>
    <name>E9BTN5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_361760</name>
        <name evidence="2" type="ORF">LdCL_360023100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865291.1">
        <property type="nucleotide sequence ID" value="XM_003865243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BTN5"/>
    <dbReference type="GeneID" id="13388177"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2320"/>
    <dbReference type="OMA" id="PRMWDAG"/>
    <dbReference type="OrthoDB" id="273572at2759"/>
    <dbReference type="PhylomeDB" id="E9BTN5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="782" mass="84154" checksum="AB553700735AFAA2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BV88</accession>
    <accession>A0A3Q8IWP7</accession>
    <name>E9BV88_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_367320</name>
        <name evidence="6" type="ORF">LdCL_360085800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865842.1">
        <property type="nucleotide sequence ID" value="XM_003865794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BV88"/>
    <dbReference type="GeneID" id="13386697"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360085800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9700"/>
    <dbReference type="OMA" id="HAEMEYR"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="PhylomeDB" id="E9BV88"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit C N-terminal" evidence="5">
        <location>
            <begin position="267"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ39167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="731" mass="81861" checksum="5DA60EFD949AA504" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8W5</accession>
    <name>A0A3Q8I8W5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_110006400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8W5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0170"/>
    <dbReference type="OrthoDB" id="267562at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF13">
        <property type="entry name" value="GH12359P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="880" mass="93669" checksum="8549231678BC8F72" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I921</accession>
    <accession>E9BAP8</accession>
    <name>A0A3Q8I921_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_110600</name>
        <name evidence="9" type="ORF">LdCL_110011400</name>
        <name evidence="10" type="ORF">LDHU3_11.0790</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859036.1">
        <property type="nucleotide sequence ID" value="XM_003858988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I921"/>
    <dbReference type="SMR" id="A0A3Q8I921"/>
    <dbReference type="GeneID" id="13389525"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0790"/>
    <dbReference type="OMA" id="HYKYERT"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000161">
        <property type="entry name" value="3-methylcrotonoyl-CoA carboxylase beta subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5428162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="536" mass="58440" checksum="AA318714A7D0A30D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9B4</accession>
    <name>A0A3Q8I9B4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Surface antigen protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120013300</name>
        <name evidence="6" type="ORF">LdCL_120013800</name>
        <name evidence="7" type="ORF">LdCL_120014300</name>
        <name evidence="8" type="ORF">LdCL_120014800</name>
        <name evidence="9" type="ORF">LdCL_120015300</name>
        <name evidence="10" type="ORF">LdCL_120016300</name>
        <name evidence="11" type="ORF">LdCL_120016800</name>
        <name evidence="12" type="ORF">LdCL_120017300</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9B4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1260"/>
    <dbReference type="OrthoDB" id="509867at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599582" description="Surface antigen protein 2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="65700" checksum="4CE3CABFFD44557D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA22</accession>
    <name>A0A3Q8IA22_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_140019900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA22"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1750"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="465" mass="50607" checksum="482FD1F25329EA1A" modified="2019-04-10" version="1">MASLIPTLAEQDPELSNMIELEMSRQFRGLEMIASENLTSKAVLECLGSALTNKYAEGEPGNRYYGGTVFVDMVENLAKKRALAAFGLDPGEWGVNVQPYSGSPANFAVYTALLEPHSRIMGLDLPSGGHLTHGFYTPKKKVSATSIYFESFPYHVKEDGLIDYDALESVALVFRPKMIITGASAYARDFDYERFRHICDEVGSLLFMDMAHTAGLIAGGVLKSPFGYADVVTTTTHKSLRGPRAGMIFYRKKDRQGKPTDHESRINQAVFPGCQGGPHEHQIAAIATQMREVCSPEWKAYAMQVQSNARALAAALSSKGHVFVSGGTDNHLLLWNVRVHGLTGSKVEKLLDAVSISVNKNTIPGDKSAMTPGGIRVGTLALTSRGMVEADMSTAAEFLDRAIVLAKQIQAAMNAMKLSDFVAALQTHAGVAALRKDVEAFATTFAMPSFDVERIKYKDSLPEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA66</accession>
    <name>A0A3Q8IA66_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_150020200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA66"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1810"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000037">
        <property type="entry name" value="Putative glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000038">
        <property type="entry name" value="Putative glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="51"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="354"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="12">
        <location>
            <begin position="465"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="570" mass="65993" checksum="BCBE4AA840E8E2C3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAH9</accession>
    <name>A0A3Q8IAH9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_160012500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0870"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000316">
        <property type="entry name" value="Putative cysteine peptidase, Clan CA, family C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="259"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="947"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1292"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1722"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1895" mass="200885" checksum="9D06A9A748DB4952" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAP3</accession>
    <name>A0A3Q8IAP3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_220013800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAP3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0940"/>
    <dbReference type="OrthoDB" id="268706at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="entry name" value="Nucleoid-associated protein YbaB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="YbaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="302" mass="35157" checksum="81B3DE1ACA0423EA" modified="2019-04-10" version="1">MEVYRRIAERVRGALWAHHRRLMPERQFHRILAYVYNNKYEYQIRFDRMSVVGRAWAGRVEVMTTPGGFLKRVRVHPAVEDLSPAQQHKLVLAAYADACQQGRALMEQAELKVYKQFLKDLKPIIFGIRDNPEFYTVPEDSMETIGGVLRRDQASLDGGAAANGAGAVHRTIPMARAHQPVDEVRRRHAWEDQWLASKQGQRWAHSLRGKEYFTRHGPQYRPRGAPGAKTRTLPFELLAPYTSMDEGRLLRKNWVAYMDSKHVAESLWTRAKVADREKQLRQLQERGQAWHRPINEDAVQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB80</accession>
    <name>A0A3Q8IB80_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heat shock 70 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_280034900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB80"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3970"/>
    <dbReference type="OrthoDB" id="242658at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="630" mass="69224" checksum="6F0044A9D1F451CC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB85</accession>
    <name>A0A3Q8IB85_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB85"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1320"/>
    <dbReference type="OrthoDB" id="276748at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133567" checksum="D4086DE5D5CF59C8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICJ0</accession>
    <name>A0A3Q8ICJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120006400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICJ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0190"/>
    <dbReference type="OrthoDB" id="272515at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="582" mass="64252" checksum="072F73ECAB0CD679" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICM4</accession>
    <accession>E9BJ27</accession>
    <name>A0A3Q8ICM4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_32850</name>
        <name evidence="15" type="ORF">CGC21_30940</name>
        <name evidence="13" type="ORF">LDBPK_270930</name>
        <name evidence="11" type="ORF">LdCL_270015900</name>
        <name evidence="12" type="ORF">LDHU3_27.1530</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861949.1">
        <property type="nucleotide sequence ID" value="XM_003861901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICM4"/>
    <dbReference type="GeneID" id="13389210"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1530"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="44"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5431219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP46086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="440" mass="47786" checksum="3F4B3E4015665A98" modified="2019-04-10" version="1">MRCVSRVFFCAAASTANSAGAASKAAAAVAAPPSTLPVFKTRPIYMDNQATTPLDPRVLDAMLPYMTEEYGNPNSRTHQYGWSAEEAVEKARKQVADLIGASPKEIFFTSGATECNNIAIKGVGNFLKAKKNHIITLQTEHKCVLDSCRYLEMEGFEVTYLPVQKNGILDLKVLEAAIKPTTCLVSCMAAHNEIGVLQPIREIGALCHSKKVLFHTDAAQALGKVKVDVNADNIDVMSMSSHKVYGPKGCGALYVRRRPRVRIRSPVSGGGQERGVRSGTVATALVVGMGAACEVAMKEWERDAAHTQRLQERLLNGLQSRLSHLVVNGDLKHRLPGNLNISFSCVEGESLLMGMKDVAVSSGSACTSASLEPSYVLRALGVDAENAHTSIRFGIGRFTTAKEVDLVIEECVKNVERLRELSPLWDLMQEGKTLADVQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICU7</accession>
    <accession>E9BBC8</accession>
    <name>A0A3Q8ICU7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_130540</name>
        <name evidence="11" type="ORF">LdCL_130010800</name>
        <name evidence="12" type="ORF">LDHU3_13.0730</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859265.1">
        <property type="nucleotide sequence ID" value="XM_003859217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICU7"/>
    <dbReference type="GeneID" id="13390455"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0730"/>
    <dbReference type="OMA" id="HFYYATS"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="288"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5428429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="607" mass="65853" checksum="A8A608124D2E052D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICZ4</accession>
    <accession>E9BH34</accession>
    <name>A0A3Q8ICZ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_241720</name>
        <name evidence="3" type="ORF">LdCL_240022800</name>
        <name evidence="4" type="ORF">LDHU3_24.2130</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861262.1">
        <property type="nucleotide sequence ID" value="XM_003861214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICZ4"/>
    <dbReference type="SMR" id="A0A3Q8ICZ4"/>
    <dbReference type="GeneID" id="13391496"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2130"/>
    <dbReference type="OMA" id="MEADKWT"/>
    <dbReference type="OrthoDB" id="441129at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF6">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="535" mass="59556" checksum="B0B34F6174E24DC5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID16</accession>
    <accession>E9BGZ3</accession>
    <name>A0A3Q8ID16_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Amastin-like_surface_protein-like_protein/GeneDB: LmjF.24.1270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_12030</name>
        <name evidence="6" type="ORF">CGC21_16260</name>
        <name evidence="4" type="ORF">LDBPK_241300</name>
        <name evidence="2" type="ORF">LdCL_240018100</name>
        <name evidence="3" type="ORF">LDHU3_24.1530</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861221.1">
        <property type="nucleotide sequence ID" value="XM_003861173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID16"/>
    <dbReference type="GeneID" id="13391143"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1530"/>
    <dbReference type="OMA" id="KMCGVKW"/>
    <dbReference type="OrthoDB" id="266442at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="174" mass="19118" checksum="F10E1D80951F7C2E" modified="2019-04-10" version="1">MGLLPPFVGALLFTVIQFLVLLFVVIATPISQIDSKTSRTCYTFWGMKSDCRKVHYTAKGKGAFGNCRQRLNNMSGGAAFAIVSVFTTLAALVFGILMLIRVSCAVVFPLIFTCISIFTIFISWACVAGAYTIKMCGMKWSNYSLEYGPGFGLMITAWCLQIVNVLVLVLISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID39</accession>
    <accession>E9BJL1</accession>
    <name>A0A3Q8ID39_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_22170</name>
        <name evidence="3" type="ORF">LDBPK_281400</name>
        <name evidence="2" type="ORF">LdCL_280018600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862239.1">
        <property type="nucleotide sequence ID" value="XM_003862191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID39"/>
    <dbReference type="GeneID" id="13386975"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1760"/>
    <dbReference type="OMA" id="HLREVRI"/>
    <dbReference type="OrthoDB" id="271923at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="439" mass="48235" checksum="2C379E3AEFE7D0D0" modified="2019-04-10" version="1">MTSRHPTRRLVDVLKQNSRKTLDRHAAQLAAAASSLPAEAIQTRFLRNQFLINPKSLQLLSTEEQLTRWHVFGVYKPPFCPMRRVEAADNYHNVSVESFVESALQSKDVYPVLKRVLKPSEVRVRVLYNLDSFASGPVLISVSDAHRYATSLQTTSMEYDLLVGGHLPVHGTGNHTVIDVAQLFPGASVPLSSSGVGADAEKASAVVPQAHYEVKENGYYSVHPVSLLHIVIRSPPTSQPPMLERFAREQLGTCVIGDPLVMGELMQLRANPAAPSSRISASSTKESSDSAQKCRGDAEDGCSGSKRDPAAQAAAMRLAANPHIVPWRGDCDFPRVFMHLREVRIDTSAETPSSVPECAYAQDSHSMLHGATMAFMGSHHSGSASREQMHAQQFAPSQEIQVHCRKCFDGLLQKQLNASFKSRRMGLLDGTWTPQTEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDA7</accession>
    <name>A0A3Q8IDA7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_190012900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDA7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0870"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="741" mass="80982" checksum="BE24EC87E784CD14" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDU2</accession>
    <name>A0A3Q8IDU2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT and BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280022500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDU2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2290"/>
    <dbReference type="OrthoDB" id="550012at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045902">
        <property type="entry name" value="SANBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021777">
        <property type="entry name" value="SANBR_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20946">
        <property type="entry name" value="SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20946:SF0">
        <property type="entry name" value="SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11822">
        <property type="entry name" value="BTB_SANBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT and BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="622" mass="66638" checksum="8CFA3F506EF97ABC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE10</accession>
    <accession>E9BK11</accession>
    <name>A0A3Q8IE10_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alkylated DNA repair protein alkB homolog 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_22850</name>
        <name evidence="14" type="ORF">LDBPK_282910</name>
        <name evidence="13" type="ORF">LdCL_280034200</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862389.1">
        <property type="nucleotide sequence ID" value="XM_003862341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE10"/>
    <dbReference type="GeneID" id="13387125"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3900"/>
    <dbReference type="OMA" id="IHHYKEF"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000009">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1210">Necrosis</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU80446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP54411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="286" mass="32143" checksum="2A877D1C5A29C07B" modified="2019-04-10" version="1">MRVVFRRLLPESTAVVAAPSSLLSMRGAPSFVHPPAEEAIGKDVRATPANWVTAYVLPEVITEQEEKTLLDFSEPWFERLSYNDGHMDGLIHHYKEFYRSYAAITQAAETGSDAGLNMPHANLEVDLPLVSGALARAHDLAQAYLPRIPIDDRVHFLRLAGSGFIRAHVDESRNSTGIVAGLCLNAGRVMTLTHPEYPGERVELMLAPRCLYILIGRARYDWAHSVDWIGDDDEHIRRIQKSLVVEGTPIRFDGAETPYRRFDRTAIIFRGVSPMTLLARRMRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE46</accession>
    <name>A0A3Q8IE46_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270017200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE46"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270017200"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="10652" checksum="9ED6700DB8508A00" modified="2019-04-10" version="1">MSSDSAVAALSAAMTSPQKSPRSSPKKTAAKKAGAKKAGAKKAGAKKAVRKVATPKKPAKKAAKKAAKKAAKKPAKKVAKKAAKKPAKKAAKKPAKKAAKKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEG6</accession>
    <accession>E9BJ96</accession>
    <name>A0A3Q8IEG6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tubulin cofactor C domain-containing protein 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Tubulin_cofactor_C_domain-containing_protein_1_pu tative/GeneDB:LmjF.27.1760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_271660</name>
        <name evidence="4" type="ORF">LdCL_270023600</name>
        <name evidence="5" type="ORF">LDHU3_27.2540</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862017.1">
        <property type="nucleotide sequence ID" value="XM_003861969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEG6"/>
    <dbReference type="SMR" id="A0A3Q8IEG6"/>
    <dbReference type="GeneID" id="13386752"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2540"/>
    <dbReference type="OMA" id="RCENCNI"/>
    <dbReference type="OrthoDB" id="427777at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="280"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5431291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="571" mass="60916" checksum="C00601566520E4CE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFT8</accession>
    <name>A0A3Q8IFT8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine esterase (DUF676), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_230016100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFT8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1300"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="359"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="931" mass="100760" checksum="78567D69F06E24CD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG34</accession>
    <name>A0A3Q8IG34_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300039300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG34"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4470"/>
    <dbReference type="OrthoDB" id="278603at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39238" checksum="1241C6D36146AF57" modified="2019-04-10" version="1">METLKGFARRTTQSLREMVSRTEVSPEEMRLTEVMAKVRIMETKGEMICEKVIQAARLMGELGTTLREIGEEYKGVPDLPKESRELADDVFEVGVKLVETSQEHQKGLKDNGFELLRSFAKQCAQLREVEDARRHHQLEYDFFKSKVQYLRSSPQRDFTRLPRNEQILENWRVELWRATERSKALCSELFVSGRQAIDRSVLTTIQVLHSFVEIASTGFSQTFQGVRLPTYPKTPVLPPTALPPAPAPAPPTPYAYSSQTAVAVPTGAIIPASPGTQAPMPGTAYASTSLPSPANPPGPVAAPQPAPLAPAIGTPYGGAPSYAVTPGAAGRGPAGYQPPPLDITTSTDNGTTTYQPPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGR3</accession>
    <name>A0A3Q8IGR3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Haloacid dehalogenase-like hydrolase/Sucrose-6F-phosphate phosphohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_280019100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGR3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1820"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47267:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE YIGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01228">
        <property type="entry name" value="COF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="335" mass="37175" checksum="D4E478F8150DE702" modified="2019-04-10" version="1">MGGAAAASDIPFRFVACDMDGTVLSPHHTLSEYTAETLRRLTQDHNVPCIFATGRVYADVAVINQNMQRFFQERRQQLPPVPATASAHTPTYIITSNGAVVHDAETGELVLEHALDPAVVREIYHLLPTSETRINTGIIQGEHWFYRMNWEEMLQFHKESGYRYQVLELIPDGDDTKGIEATSTPTVASSAAGGNLDHVHKIFFSSWNPTLLEKLEQALQQRYGDDLTVTFSAPHNVDITAKGVTKAWALERLYALMAPLPHETASTATPAQRLRATVAFGDDLNDAAMLSSVGRGFIMGNCSPKLRQQCPELEVIQTNTEDAVARKLREVFRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH50</accession>
    <name>A0A3Q8IH50_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pteridine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_100009500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH50"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0600"/>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17484">
        <property type="entry name" value="MFS_FBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="722" mass="79015" checksum="214BCB4574EF4BF5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ81</accession>
    <accession>E9BLG9</accession>
    <name>A0A3Q8IJ81_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_300760</name>
        <name evidence="6" type="ORF">LdCL_300012700</name>
        <name evidence="7" type="ORF">LDHU3_30.0970</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862789.1">
        <property type="nucleotide sequence ID" value="XM_003862741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ81"/>
    <dbReference type="SMR" id="A0A3Q8IJ81"/>
    <dbReference type="GeneID" id="13385496"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0970"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000018">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5432093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23784" checksum="0D8CD4179DD68FB6" modified="2019-04-10" version="1">MRALSLRTGLVARASAVAYTSQRWCSADAKSEKRAEEEKEAPSTGTEEVVSAAAVKQLEKELDASKAKIEELKKEILYRAADAENARRIGREDVEKAKLYGISSFGKDMLEVADTLEKGVEAFSAFSEAELNENKILCSIFTGVKLSHKVLLKNLSKHGIEKMGVTVGTKFDPNLHDALVSTSATETAPADTISNVLKDGYTLKSRVLRAAQVSVSQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJJ3</accession>
    <name>A0A3Q8IJJ3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_34885</name>
        <name evidence="7" type="ORF">CGC21_21115</name>
        <name evidence="5" type="ORF">LdCL_320037700</name>
        <name evidence="6" type="ORF">LDHU3_32.4040</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJJ3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320037700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4040"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5433076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="150" mass="16709" checksum="715EAC1CA94BEFC5" modified="2019-04-10" version="1">MAGLALCLFSLDATRLSGISHTGDPAEAERSRRLLSILEKLHWLLIALLTWNDFALEMLPLILRTLLPLVMIVTSVAVTLLFCEILSRAFFIQNAFEVSAFLSPFIRVLMCITAPVAWPISQLLGGVVGDKDAVFFQLRELRDVIRIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJK6</accession>
    <name>A0A3Q8IJK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RNA-binding_protein_putative/GeneDB:LmjF.30.2610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_300031600</name>
        <name evidence="6" type="ORF">LDHU3_30.3500</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJK6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3500"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5432284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23110" checksum="65D90B2151A93075" modified="2019-04-10" version="1">MSSNQDDHGGEMISAEDQFNVDMDAEAELEEMKRQVESLQEDMQLKALQESAAKDEGTRKTAAAAAASSGQTKTNTSIFVGDLDLRTTDADLRVFFASCGAITRVTVLKDRQGNPKGTAYVEFETEGQAHAAILKDGQSLHGKPLKVAMKRDNIPAFQRGISRGGAYALRGRGAGNPMQQQIAALAMMAGMMSQGFNPYNMGRGGGRGRGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJP8</accession>
    <name>A0A3Q8IJP8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stress-inducible protein STI1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360005600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJP8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0130"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000221">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="255" mass="29009" checksum="5F0188A550B55A5A" modified="2019-04-10" version="1">MEDYKAKGNDAFKAKRYQEAIDWYTKAIELDPNGEASGALYSNRAGSWQNLNNFEKAAVDSKQCIRLRPDWLKGYFRLGVAMESMGKYDEAQKAFQKALQLSPGNEEVMDKLHTVNTKVRERNEKTKSQQCKTPEEAKQLGNSFFKDGKYDQAAEFYTRAIELQTEPVKEKAVYYTNRAACHQQTHMYSLMVDDCNAAIEIDPANVKAYLRRGIAYEGVEKWKLALEDYTKAQSISPGVAGASQGILRCQRVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKW3</accession>
    <accession>E9BNK4</accession>
    <name>A0A3Q8IKW3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ubiquitin-conjugating_enzyme_protein_putative/Gen eDB:LmjF.32.0960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_33835</name>
        <name evidence="10" type="ORF">CGC21_20075</name>
        <name evidence="9" type="ORF">LDBPK_321010</name>
        <name evidence="7" type="ORF">LdCL_320015800</name>
        <name evidence="8" type="ORF">LDHU3_32.1350</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863517.1">
        <property type="nucleotide sequence ID" value="XM_003863469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKW3"/>
    <dbReference type="SMR" id="A0A3Q8IKW3"/>
    <dbReference type="GeneID" id="13390330"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1350"/>
    <dbReference type="OMA" id="WNPTQNI"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5432858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP43616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="271" mass="29945" checksum="EBAD282E79F30767" modified="2019-04-10" version="1">MSALPHIQKEFRNLTKDPPAGFRVELKDNSFFTWIVWFTGPEGTPYAGGQYKASLTFPKEFPMEPPTFRVISSFWHPNVYADGRVCISILHPPGVDEMNSEETAMMRWTPVQTIRSVLLSIVSLWSDPDPSDAGAPANVDALVQYRNRRAEFDAKCRSLAEKSLTELPEDFEPPCMEEKVEVTKAPGDTFDYMLSEDDLEDEDDFDDFSTPAPAASASAGAAASSDPAKKYAEELMQLRAMGVGEGKSDADLLNLLIKHRGELASVIGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INE3</accession>
    <accession>E9BR08</accession>
    <name>A0A3Q8INE3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_21410</name>
        <name evidence="15" type="ORF">CGC21_26345</name>
        <name evidence="14" type="ORF">LDBPK_342100</name>
        <name evidence="12" type="ORF">LdCL_340028700</name>
        <name evidence="13" type="ORF">LDHU3_34.3520</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864369.1">
        <property type="nucleotide sequence ID" value="XM_003864321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INE3"/>
    <dbReference type="SMR" id="A0A3Q8INE3"/>
    <dbReference type="GeneID" id="13392778"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3520"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000032">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5433794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ37687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="143" mass="16844" checksum="99F6B15A371FC5B0" modified="2019-04-10" version="1">MIHFILLQNRMGKTRLAKFYIPVDDAGQAQIKRQVHVIVNTRDTRATNFVSYESIKLVYRRYAGLFFILGIDQEDNDLMYVELIHLLVEVLDMFFKDVCELDLIFNFHKVFMIIDEMIMGGEIQEVSRPVILNRLQELEISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQ44</accession>
    <accession>E9BSX4</accession>
    <name>A0A3Q8IQ44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_14500</name>
        <name evidence="5" type="ORF">CGC21_7700</name>
        <name evidence="4" type="ORF">LDBPK_354550</name>
        <name evidence="2" type="ORF">LdCL_350050600</name>
        <name evidence="3" type="ORF">LDHU3_35.5990</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865032.1">
        <property type="nucleotide sequence ID" value="XM_003864984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQ44"/>
    <dbReference type="GeneID" id="13387910"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350050600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5990"/>
    <dbReference type="OMA" id="EWNSSEN"/>
    <dbReference type="OrthoDB" id="240947at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="190" mass="21213" checksum="65D9E34E4DFEC015" modified="2019-04-10" version="1">MSTKEDTPASLASAVDTPASLLDAKASALLEEFDTFFSQGKNTDRLRNFIEENDDTLALVASESEVNTNTEGSLRLYQLFQRYVALIEDIIEEFVATTEKSDESMLRFLASAIQEEWRSPSTAYRCVCTSYIAASMDYKDFLEFAEDLYSVTHYRMHVREEDSSEEEDGEEIVDNVGGGGGYGSDDPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQ96</accession>
    <accession>E9BK53</accession>
    <name>A0A3Q8IQ96_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_14005</name>
        <name evidence="6" type="ORF">CGC21_21615</name>
        <name evidence="4" type="ORF">LDBPK_280130</name>
        <name evidence="2" type="ORF">LdCL_280006200</name>
        <name evidence="3" type="ORF">LDHU3_28.0160</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862114.1">
        <property type="nucleotide sequence ID" value="XM_003862066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQ96"/>
    <dbReference type="GeneID" id="13386850"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0160"/>
    <dbReference type="OMA" id="YGACAGP"/>
    <dbReference type="OrthoDB" id="258750at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="182" mass="20664" checksum="7203B03756431A3B" modified="2019-04-10" version="1">MHIFRVSVPLMCLFYHFIVVIISFANYIIFVKLQGTPRALCDAYLALCVVETVAYGACAGPLFVYSYKYGKTSTARLGRLLGGIVVMFLLSSLPMVIIETALFLSFDLELRHSLDGTVFFLHATAAVFGGFTTWFAYMRVVARFLQRWRGPERQIADDSEIPPTKDVQLHLVRRSQWQPETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQV2</accession>
    <accession>E9BTP9</accession>
    <name>A0A3Q8IQV2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ras-like small GTPase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ras-like small GTPases, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_13255</name>
        <name evidence="5" type="ORF">LDBPK_361900</name>
        <name evidence="4" type="ORF">LdCL_360024500</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865305.1">
        <property type="nucleotide sequence ID" value="XM_003865257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQV2"/>
    <dbReference type="GeneID" id="13388191"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2470"/>
    <dbReference type="OMA" id="RQYLHHE"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="873" mass="92349" checksum="66457A4714BE8FBE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IV54</accession>
    <accession>E9BS30</accession>
    <name>A0A3Q8IV54_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Reiske iron-sulfur protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Rieske iron-sulfur protein, mitochondrial, putative</fullName>
            <ecNumber evidence="14">1.10.2.2</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Rieske_iron-sulfur_protein_mitochondrial_precurso r_putative/GeneDB:LmjF.35.1540</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Ubiquinol-cytochrome c reductase, iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_0260</name>
        <name evidence="17" type="ORF">CGC21_6290</name>
        <name evidence="16" type="ORF">LDBPK_351540</name>
        <name evidence="14" type="ORF">LdCL_350020300</name>
        <name evidence="15" type="ORF">LDHU3_35.2060</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.10.2.2" evidence="14"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864739.1">
        <property type="nucleotide sequence ID" value="XM_003864691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IV54"/>
    <dbReference type="SMR" id="A0A3Q8IV54"/>
    <dbReference type="GeneID" id="13387619"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2060"/>
    <dbReference type="OMA" id="DERQCTT"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU82953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5434176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ38059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP46394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="297" mass="33726" checksum="17D9F4DC75439B4B" modified="2019-04-10" version="1">MFRRSFISAFQATRAARVSLVFKQLEGNMPLTKKDKPVDSWSDEFMKPPQSAEMTKKYGRYAKYSDPALCDVDTSDEVVLNTYPEGAPQGRIEATAGVALKDYDASMWDEEFFRKHILKPKLADDMEDRARVTDYALNSAMLGFVILMARYAVLPLWYVGQPAMSMVGQMNIEAEIGELDERQCTTVVWRGKPVFVYRRSARQMKEVMETPLSALKDPETDEARFPDRRDKAVVIAICTHLGCVPIPNEGLFNGFFCPCHGSHYDPSGRIRQGPAPLNLEVPPYRWIDDNTIYMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5L3</accession>
    <accession>E9B8J3</accession>
    <name>A0A3S5H5L3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_9720</name>
        <name evidence="4" type="ORF">LDBPK_051030</name>
        <name evidence="2" type="ORF">LdCL_050015600</name>
        <name evidence="3" type="ORF">LDHU3_05.1150</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858290.1">
        <property type="nucleotide sequence ID" value="XM_003858242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5L3"/>
    <dbReference type="GeneID" id="13391622"/>
    <dbReference type="KEGG" id="ldo:LDBPK_051030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_051030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1150"/>
    <dbReference type="OMA" id="TWGIFYW"/>
    <dbReference type="OrthoDB" id="275586at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="145" mass="16289" checksum="64BC20F05D6A6372" modified="2019-04-10" version="1">MQCTFLKLSSRRGSAFATSLFLHASSQNMRAADAAQRIEVEEFAKSYQMKPMADHPRSSFEYKSSAKGAEVGARNEAAFMNYETFTPQTLSGRLVMPGDINLLTVSPLYCALLCIAAAAWGVFYWDMYCRKNYETVLIARPKDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H671</accession>
    <name>A0A3S5H671_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080013500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H671"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1160"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="649" mass="69966" checksum="A4544EA7AC52E673" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H697</accession>
    <name>A0A3S5H697_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_080017600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H697"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1660"/>
    <dbReference type="OrthoDB" id="257378at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU76428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="443" mass="49781" checksum="C0F4B577F60EAF95" modified="2019-04-10" version="1">MREIVSCQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDESTGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRISTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEQEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6C5</accession>
    <name>A0A3S5H6C5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring finger domain/RING-H2 zinc finger containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_090008900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6C5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0490"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="875" mass="89135" checksum="F24C20D0B78E9F43" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6T1</accession>
    <name>A0A3S5H6T1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_140020300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6T1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1800"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000040">
        <property type="entry name" value="Inositol 1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000888">
        <property type="entry name" value="Myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="16">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU77395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="526" mass="58353" checksum="2332A01B3FD73A68" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H738</accession>
    <name>A0A3S5H738_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_180015500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H738"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1290"/>
    <dbReference type="OrthoDB" id="266037at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018783351" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11506" checksum="44C04A7A4DA4A29F" modified="2019-04-10" version="1">MSAIRTLIAAVALAAIFFVSPAAAAPGDLVENVNNQTCSKGCVAGLLVMAAIISVVFASLMCFIFWPAAELTSRQEGRVIARKRIRDRRVAEEESRAKNEVLDGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H749</accession>
    <name>A0A3S5H749_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clathrin light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_190006000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H749"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0110"/>
    <dbReference type="OrthoDB" id="278062at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="395" mass="41762" checksum="D0022E97A6688FA5" modified="2019-04-10" version="1">MGLPVLHYICTCMHAGIPPRSVHADTCSFVHLSFSLFCLLPLFVSPFFASFCHFRRLHLSVHADVPALTHKADALLTTAAPFFCVCCCCGSFQRHYHHTTTSSVMDSGYPRPSGITVGSPGLPPGSLGSPFPEQMNSPHSSDAMQGSNASQVPLTMHADGGQHSKPHSPPLTSGAEVLSAPHHSHLAGVNAPWDEDDDWTTPGAPAQHSASAAAPAKLPLPPGNHAAPPVSIAEQTNPGSPAEPHPTPVAMSPPPSDGFIASSSPGGSPNRPPTPPEKPSAANVAKMDALKKQIASRTAAMDAATKEKETKIMTAAQEYLKALMAKREEEVMNAKASHKEEQQVGAEKINEYKRSGAVWSAVGLLVDLQKPNQYSKSTEQMRTVLSTLNAAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H762</accession>
    <name>A0A3S5H762_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_21820</name>
        <name evidence="9" type="ORF">CGC21_19170</name>
        <name evidence="7" type="ORF">LdCL_190013600</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000034">
        <property type="protein sequence ID" value="TPP44808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H762"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1060"/>
    <dbReference type="OrthoDB" id="261813at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000221">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP50983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="121" mass="12560" checksum="8E9F9DE978068CCD" modified="2019-04-10" version="1">MCAYHSSNPVEARRAECARLQAKYPGHVAVVVEAAEKAGSKAHFLALPRDATVAELEAAVRQALSTSVKKVTLAIEGSAPAVTAAVGDIADACKRDDGFLYVSVRTEQAMGAFASPCLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7D3</accession>
    <name>A0A3S5H7D3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_240019700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7D3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1760"/>
    <dbReference type="OrthoDB" id="272558at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018724878" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="36"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="917"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="99518" checksum="7353144CC9EECD2B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7S4</accession>
    <name>A0A3S5H7S4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Aquaporin-like_protein/GeneDB:LmjF.32.2370</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Major intrinsic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_34560</name>
        <name evidence="9" type="ORF">LdCL_320030500</name>
        <name evidence="10" type="ORF">LDHU3_32.3130</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7S4"/>
    <dbReference type="SMR" id="A0A3S5H7S4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3130"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019755">
        <property type="term" value="P:one-carbon compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000059">
        <property type="entry name" value="Aquaporin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45665:SF9">
        <property type="entry name" value="AQUAPORIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5433005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="278" mass="30156" checksum="CAD69A0E520B1560" modified="2019-04-10" version="1">MCALQRDAATRAEKQPYLARQIPMIRLSRYQAKFVCEGIGTFIFLMTTSLAEMNCGNLAVDGKTRTRNLAPIAEGFMLCVLIFMFGYISGGHFNPAVTFAVVMIRGMRVEEAISYWVAQVVGALVGAGLSILVHGSTQHLPAPQVVQNTAEYVFSAFVAEAVFTMLLVTVVLHAAYSQQRNNDFYGLAVGMCLLASQYAVGGVSGGAFNPAVATGLQVTKFIAAGYFTQLLYLWLYWAAPACGAVAAAFLFMMTHPVPKDEAGEVQQQRVARNLYSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNR5</accession>
    <name>A0A3S7WNR5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_040010400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0650"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF47">
        <property type="entry name" value="POLYMERASE SIGMA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2053"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2457"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2777"/>
            <end position="2804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2852"/>
            <end position="2882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2903"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2944"/>
            <end position="2997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1558"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2053"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2083"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2127"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2490"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2789"/>
            <end position="2804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2868"/>
            <end position="2882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2997" mass="307722" checksum="83A7A329C0397BD2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPK2</accession>
    <name>A0A3S7WPK2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_060014800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPK2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1110"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="81"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="588" mass="63034" checksum="830121E5CBB6F569" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ93</accession>
    <name>A0A3S7WQ93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080011400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0710"/>
    <dbReference type="OrthoDB" id="266995at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1809"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1963"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2040"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2161"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1694"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1809"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1831"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2161"/>
            <end position="2177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2194" mass="231610" checksum="0111A8FEDBA1134B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQJ5</accession>
    <name>A0A3S7WQJ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA photolyase, putative</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_090009000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQJ5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0500"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="228"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="739"/>
            <end position="741"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="932" mass="102243" checksum="B37DADB85F39C266" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR02</accession>
    <accession>E9BA75</accession>
    <name>A0A3S7WR02_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_100270</name>
        <name evidence="6" type="ORF">LdCL_100008000</name>
        <name evidence="7" type="ORF">LDHU3_10.0400</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5427981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858866.1">
        <property type="nucleotide sequence ID" value="XM_003858818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR02"/>
    <dbReference type="SMR" id="A0A3S7WR02"/>
    <dbReference type="GeneID" id="13389273"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0400"/>
    <dbReference type="OMA" id="LWAFCYG"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF16">
        <property type="entry name" value="4A-HYDROXYTETRAHYDROBIOPTERIN DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5427981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="259" mass="29229" checksum="65873C02A2D8B536" modified="2019-05-08" version="1">MRQRSSFSTVSSAAMFENTLTTQRAQKGDYGFNVFHNSNPQHGGSYARHERRMREDEVEDFLKSVKHWRPVYEDVADGDLVGDAQSSSSTSASAAEPPMPRLARMGEEAIMRTFHFETFREAYLFMGRVWAFCYGSDKYPHVTWEGTAITVYLYSPSFRGLSKREARVAAFLNDQYNMLRKSKWQQRRIVDGIVRQTAVEELLGEEVAAHLARREALRTAPLQEVKDGPRSWRSAIGSPLRSPNSGSDGAGSSMGVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WS93</accession>
    <name>A0A3S7WS93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_120020000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WS93"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120070r.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1580"/>
    <dbReference type="OrthoDB" id="267782at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1009" mass="103107" checksum="3F633FAF9A512259" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSA2</accession>
    <name>A0A3S7WSA2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_120020700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSA2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1660"/>
    <dbReference type="OrthoDB" id="267299at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="639" mass="67614" checksum="4808FB34BA81B9A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSP0</accession>
    <name>A0A3S7WSP0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPRY domain/HECT-domain (Ubiquitin-transferase), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_130019300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1670"/>
    <dbReference type="OrthoDB" id="239701at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="26"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="4271"/>
            <end position="4503"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="4554"/>
            <end position="4787"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="5104"/>
            <end position="5610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1535"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1685"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1773"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1938"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2089"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2423"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4113"/>
            <end position="4148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4196"/>
            <end position="4242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4255"/>
            <end position="4298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4667"/>
            <end position="4686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="5401"/>
            <end position="5554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1535"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1694"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1773"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2106"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4196"/>
            <end position="4207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4226"/>
            <end position="4242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="4264"/>
            <end position="4273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="5434"/>
            <end position="5447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="5455"/>
            <end position="5483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="5484"/>
            <end position="5509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="5540"/>
            <end position="5549"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="5574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="5641" mass="593551" checksum="4F82B4A1C03FDC9D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSX9</accession>
    <name>A0A3S7WSX9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SpoU rRNA Methylase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_140011600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSX9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0840"/>
    <dbReference type="OrthoDB" id="262525at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="TRNA/RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786:SF6">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="52501" checksum="FB87081D2196F1F0" modified="2019-05-08" version="1">MMPWVAGGNVASGAPLTAAAPSSSCTPPHGTTSPPCDAVTKAVCASPTSSTPALHGKPHKERKMQELDPLTRWRCRRCGVVLQPPLDAATGKPRYGVMMTEHLEGISSGGTTRLATGVVVCASGTMRYEKVLHEKDTLSHPQPSKRPRDDAGEGLARGRATEEDSVVAGTRESQSHEHDDIDKTTACEAIRRLLRQCQQGARQHGNANASPSPLLFIVVENPKTPANAGGILRAMRCYGLHGPAVAAATVAASTEEVTDSCMSVSASMHTTVEAVAESAEGSVRHRVGSFIYSGTRLQKAMAHSEYTHALRTDPTHAGRDIPQLCVPALDVLFDVLRDEYGYQQKEPRSPSPSSVCVVAVELVEGAIPLPFYEHPFSHPTQQGPLPRVEKDATSTVAHLPMVFYVLGAEDGTLSAHHVQHDVDDVVFIPTTGSMNLAATVNVLLYDRLSKECCGVHPGVAEALSTGSRWKDVFDTRNANNRMRWTRTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT30</accession>
    <accession>E9BBZ1</accession>
    <name>A0A3S7WT30_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_38395</name>
        <name evidence="4" type="ORF">CGC21_4955</name>
        <name evidence="3" type="ORF">LDBPK_141090</name>
        <name evidence="1" type="ORF">LdCL_140016600</name>
        <name evidence="2" type="ORF">LDHU3_14.1360</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859476.1">
        <property type="nucleotide sequence ID" value="XM_003859428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT30"/>
    <dbReference type="SMR" id="A0A3S7WT30"/>
    <dbReference type="GeneID" id="13391128"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1360"/>
    <dbReference type="OMA" id="LPRCNGH"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5428649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="505" mass="57055" checksum="E7930E4808C0D932" modified="2019-05-08" version="1">MIGLKSMAGVRDVVRGGSWPARLLDMFTSRAAQESFEFEAVVTDACAAANVAVPSEAHLPHARWWKKLCRACQDKTGTTKHGSQLLRSRLTNALAQRLAVEEVYRLNGGEIAKEPAVENPIVIMGLPRSNGHMAAHVLARSGLFLTPRQCDTLSPSLLLDVERRDAFRKKFRGFSYLHPDFLCVRVPQADQVDDDLTLHLMTPQSYAWGLLHGLDEYLLECLEEDQLPVYTEVRRVIELLQWYRKCGHFSEPVTREFDPIDNVMELQAYGTKNVLLRPQWLLYSPFAILSPDAVNTVFPKMKAIWVHRALSQCLPSLCSALCLHNTLYTGKPPSDSQLASMGEKVLGIFGSGTAYAIEYYGKFDQRRMAHWSNRDVKRHATRVATKTLDYFSIELDRYRRMQMISGQTEYVSVSRPLHDAQMPYFCLHDGVIGDVFQDYIYQFAEFAFERKFGITVKEYTPLAAPADAMAMRGIAHGSSEPRSAPALGAGQPMVGHFQQERRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUI0</accession>
    <name>A0A3S7WUI0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GMP reductase</fullName>
            <shortName evidence="13">GMPR</shortName>
            <ecNumber evidence="13">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="13">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GMPR</name>
        <name evidence="24" type="ORF">CGC20_37655</name>
        <name evidence="23" type="ORF">CGC21_4055</name>
        <name evidence="21" type="ORF">LdCL_170014700</name>
        <name evidence="22" type="ORF">LDHU3_17.1280</name>
    </gene>
    <organism evidence="21 25">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 25">LdCL</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">FDAARGOS_360</strain>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10 13">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="13"/>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000040">
        <property type="protein sequence ID" value="TPP55086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859941.1">
        <property type="nucleotide sequence ID" value="XM_003859893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUI0"/>
    <dbReference type="SMR" id="A0A3S7WUI0"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1280"/>
    <dbReference type="OMA" id="PGSHCTT"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000003">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF122">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="12" id="KW-0327">Glycosome</keyword>
    <keyword evidence="19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="5 13" id="KW-0521">NADP</keyword>
    <keyword evidence="7 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="2 13" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="99"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="352"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="454"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAC5429139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP51712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP55086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="492" mass="52011" checksum="852073775CB6C3B5" modified="2019-05-08" version="1">MAALGSLPTLPEGLTYDDVLLIPQRSPVRSRKAVNTSTRLSRNIHLKIPIVASNMDTVCEDKTAVTMAREGGIGILHRFCSIEEQCAMVRKVKRAQSFLIEDPRMILPSATKAEALEELNWSGRKGGVSCLMVVDDFTSRRLCGVLSKSDLIFATDSALVETLMTPVSRTVVSTNTAITLEEAREVMRTKRTSNIPLLGPKGELLYLITQSDILKLTGNRNATLDSRGRLIVGAAIGVKKEDHKRAAALVDAGADVLVVDIAHGHSDLCIDMVKALKVNPLTNKVDIIAGNIATAEAAQDLIDAGADGLKIGVGPGSICITRLVAGSGVPQLSAVMDCARVAKKHGVPCIADGGVKTAGDICKAIAAGADTVMLGNMLAGTDEAPGRVLVKDGKKVKIIRGMAGFGANISKAEREKRLDEDVFNDLVPEGVEGSVPCKGPLAPILKQLVGGLRSGISYCGSHSIADMQQRARFVRMSGAGLRESGSHDISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV17</accession>
    <accession>E9BDU1</accession>
    <name>A0A3S7WV17_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeats (Many copies)/Ankyrin repeats (3 copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ankyrin_repeats_(Many_copies)/Ankyrin_repeats_(3_ copies)/Ankyrin_repeat_putative/Pfam:PF13857/Pfam:PF12796/P fam:PF13606/Pfam:PF00023/Pfam:PF13637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_181110</name>
        <name evidence="3" type="ORF">LdCL_180016300</name>
        <name evidence="4" type="ORF">LDHU3_18.1410</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860124.1">
        <property type="nucleotide sequence ID" value="XM_003860076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV17"/>
    <dbReference type="GeneID" id="13385964"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1410"/>
    <dbReference type="OMA" id="CLHRAVN"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207:SF2">
        <property type="entry name" value="REPEAT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207">
        <property type="entry name" value="SURFACE ANTIGEN BSPA-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="231" mass="25283" checksum="CEE99FEC805C2BEE" modified="2019-05-08" version="1">MQAPYNSPVLTEDEEWSTPFATACSVGAPLDLLREILDRSVVELAAHMKQKEAQRNPTSEEQNGSSAALTEPAQGSNDGKPTKFLSGMPGISQPVDATPASISAVLVDAEDATGQTPLLLAVGRGHLSIVRFLLENGANLMHQNRRGQSCLHRAVNRGNMELVEFLVTTSEKNNAKSKAAHRAWMDLRDKHGDSALFYASMDNNEEIGRYLLRHGADRELRNADGKAFWEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV41</accession>
    <accession>E9BDY7</accession>
    <name>A0A3S7WV41_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Zinc finger, C3HC4 type (RING finger) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Zinc_finger_C3HC4_type_(RING_finger)_containing_p rotein_putative/Pfam:PF13920/Pfam:PF13923</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_39005</name>
        <name evidence="6" type="ORF">CGC21_5440</name>
        <name evidence="5" type="ORF">LDBPK_181560</name>
        <name evidence="3" type="ORF">LdCL_180020900</name>
        <name evidence="4" type="ORF">LDHU3_18.1980</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000025">
        <property type="protein sequence ID" value="TPP50598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860170.1">
        <property type="nucleotide sequence ID" value="XM_003860122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV41"/>
    <dbReference type="SMR" id="A0A3S7WV41"/>
    <dbReference type="GeneID" id="13393458"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1980"/>
    <dbReference type="OMA" id="IEAMQFV"/>
    <dbReference type="OrthoDB" id="271225at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP55200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="154" mass="16875" checksum="36D3BA6A4B55BFD4" modified="2019-05-08" version="1">MSGLELIALVPIGIAGWKLFQKLGDQQSLIAQHELTINSQKEMLESIVNADRAGPLSRLNLAVVAGTLVLAGTVTYKSWTLTKSFTVRPPPNYEPTPATFDAEQCVICLENCKDTVFLPCRHLCTCWSCASRIGNSACPTCRAPIQAMQFVYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVJ3</accession>
    <accession>E9BEB9</accession>
    <name>A0A3S7WVJ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPFH domain / Band 7 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SPFH domain / Band 7 family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SPFH_domain_/_Band_7_family_putative/Pfam:PF01145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_8690</name>
        <name evidence="6" type="ORF">CGC21_18980</name>
        <name evidence="4" type="ORF">LDBPK_191270</name>
        <name evidence="2" type="ORF">LdCL_190017800</name>
        <name evidence="3" type="ORF">LDHU3_19.1530</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860302.1">
        <property type="nucleotide sequence ID" value="XM_003860254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVJ3"/>
    <dbReference type="GeneID" id="13386114"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1530"/>
    <dbReference type="OMA" id="RVYTFDM"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="CDD" id="cd03407">
        <property type="entry name" value="SPFH_like_u4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="277" mass="30760" checksum="705608E9C853BF0C" modified="2019-05-08" version="1">MGTCPSISQSEVGIVETCGRFSYTADPGIHCLWCGSILVRRITLRLQEYELKVESKTKDNVFVTLSLVIQYQVAPDKLAEVYYACDSSLECMRDYVLNSIRAKIPLYKLEALYVERGTISQQLKDEVDAIINTYGIEIVSALISDIDPGAEITKAMNEVQKFQRLRVASVDAAETEKLKRVRAAEARCEARRLSGEGLAEQRKAIVAGLMQSIEDVQSEVRDLSSNDATNMLLMNQYYDTLQAIAANSSSSVIMLESNGGLEKVAAQLRQGVTHMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW07</accession>
    <name>A0A3S7WW07_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200015900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1380"/>
    <dbReference type="OrthoDB" id="266722at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1462"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1583"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1693"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1747"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1832"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1919"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1546"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1747"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1785"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1925"/>
            <end position="1936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1950" mass="203091" checksum="2D938159B5A2F478" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXY2</accession>
    <accession>E9BGG1</accession>
    <name>A0A3S7WXY2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_231470</name>
        <name evidence="2" type="ORF">LdCL_230021800</name>
        <name evidence="3" type="ORF">LDHU3_23.1970</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861040.1">
        <property type="nucleotide sequence ID" value="XM_003860992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXY2"/>
    <dbReference type="SMR" id="A0A3S7WXY2"/>
    <dbReference type="GeneID" id="13390240"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1970"/>
    <dbReference type="OrthoDB" id="277635at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="77" mass="9039" checksum="8FDEDCF66500E25E" modified="2019-05-08" version="1">MSAEREQEVLQMAERMQTKDTSTEVPVASFAYEILKAHPSVRDMGLRERMDFLLKRWNRLSKAQKLDYVNDPLRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY66</accession>
    <name>A0A3S7WY66_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calmodulin-binding family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Calmodulin-binding, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Calmodulin-binding_putative/Pfam:PF13864</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_11525</name>
        <name evidence="8" type="ORF">LdCL_240005900</name>
        <name evidence="9" type="ORF">LDHU3_24.0120</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY66"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0120"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF3">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5430341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP44827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="279" mass="30719" checksum="45C5693423D14CEE" modified="2019-05-08" version="1">MSGECVYDLVTASDSLGAGGTVVTVKPAATAKKSRRAPPPTASTFGIHGTSAVVANAGGEYTDASVHPSRKPIGTFGREVGSTVTPENFLRKNEGPLTASRGAPTVDNSAFKKSEYHREKAKPDVPLRNERPVMGLRTEKNFVVANAVENTMAVPTKVTPAPQPRATDREDFGKVPQYITEIKEDMNARKQMLEDHKAADRAAQERWSEISPSELAQLLEGLQRRWDALNKDYQTKGFSKLETPSQRAHQELVEKQLVAVEFSMQKLSRQHVFVFDDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYA6</accession>
    <name>A0A3S7WYA6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_240015700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYA6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1250"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="269"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="803"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1273" mass="139778" checksum="D255772B69A57144" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZG4</accession>
    <name>A0A3S7WZG4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_260005300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZG4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0050"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="476"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="795"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="973" mass="106434" checksum="F2EAB77697679991" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZQ3</accession>
    <accession>E9BI53</accession>
    <name>A0A3S7WZQ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_4775</name>
        <name evidence="4" type="ORF">CGC21_31610</name>
        <name evidence="3" type="ORF">LDBPK_260400</name>
        <name evidence="1" type="ORF">LdCL_260009500</name>
        <name evidence="2" type="ORF">LDHU3_26.0510</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP51938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861629.1">
        <property type="nucleotide sequence ID" value="XM_003861581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZQ3"/>
    <dbReference type="GeneID" id="13388874"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0510"/>
    <dbReference type="OMA" id="CVCPGCQ"/>
    <dbReference type="OrthoDB" id="257001at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="100" mass="11721" checksum="B8C1F352C7D09ACA" modified="2019-05-08" version="1">MTDHLSKHHVWRDYYREAKQATSAPMKCPYCKRQGRFAANTYEIAKRIPSVMSEGMALCHFCETPIGRQADVVLQLRSWYCGYCELCVCPACQKKQRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZV1</accession>
    <name>A0A3S7WZV1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260013700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZV1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1060"/>
    <dbReference type="OrthoDB" id="272571at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="945" mass="100343" checksum="B4CF7E73771D31C4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X117</accession>
    <accession>E9BJG1</accession>
    <name>A0A3S7X117_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_18620</name>
        <name evidence="2" type="ORF">LDBPK_272310</name>
        <name evidence="1" type="ORF">LdCL_270031500</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000015">
        <property type="protein sequence ID" value="TPP53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862082.1">
        <property type="nucleotide sequence ID" value="XM_003862034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X117"/>
    <dbReference type="GeneID" id="13386817"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3540"/>
    <dbReference type="OMA" id="CTRDSYA"/>
    <dbReference type="OrthoDB" id="276683at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="384" mass="41137" checksum="FCC93E6CB00156AC" modified="2019-05-08" version="1">MPSAATLSIDAHKWTETIEAAGTDCLCSAVSAKNVTHVLSTATVRAPQKHLCAAVSNFVPAMLENLHGVSILTALVRYGTTATVEQIASKLSAADEGVWSFMAAPKKELTKCLSHLLERMVYREDCTGESYNALLGRLKAVKKQSLMTSSFTLPAAARLALVDDAFATGLLSSSEAQKALGKSCQHAATAAAAEEFCRILFERPKDNAAGDFVWKALAASMKADAKAHPREAILALLAAHGPVPLVNKMADAMAQWSTVRELCTRDSYAHIVARLLERCDDERAGNRLVAAVIMQEADVTERVGARKAAQHHLLAVLAAKSSYAQTLEKRLGTSQTKRLAAAKVRFANATQSKATTTQQAILEKLKKLHSTTTSSVAGTKRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Z1</accession>
    <accession>E9BL98</accession>
    <name>A0A3S7X2Z1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_7680</name>
        <name evidence="5" type="ORF">CGC21_34835</name>
        <name evidence="3" type="ORF">LDBPK_300030</name>
        <name evidence="1" type="ORF">LdCL_300005300</name>
        <name evidence="2" type="ORF">LDHU3_30.0080</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862719.1">
        <property type="nucleotide sequence ID" value="XM_003862671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Z1"/>
    <dbReference type="GeneID" id="13385425"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0080"/>
    <dbReference type="OMA" id="DNWMNDK"/>
    <dbReference type="OrthoDB" id="274897at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="238" mass="28567" checksum="6AA1D8B6B43EAB26" modified="2019-05-08" version="1">MRRLQRRILSARTPVRLFDSDERFGKELGFGHKMRDIPVLTGNPRPVAREESWRCAYKLSDRMEFVVRDILTKNKWSPLEVDRELAHIFERKEVGSRSSLNTWSTVEEFQRTPWYRRYKPTDDTAAKFISYEAMKLLESALIPPSLRTDPYAHLRKRHMEDNWINDKFSEDTARYITRERLAQHTKGMPQYGQMSRRKYMEFERKFRNMHGSNMHVNEIYSAWLNSLDAKDGEKRQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3M0</accession>
    <name>A0A3S7X3M0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat shock 70-related protein 1, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_300031000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3M0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300031000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3400"/>
    <dbReference type="OrthoDB" id="276171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000026">
        <property type="entry name" value="Heat shock 70-related protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="549"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="654" mass="70951" checksum="0D361DD78730BA37" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4K3</accession>
    <accession>E9BMT8</accession>
    <name>A0A3S7X4K3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_3320</name>
        <name evidence="15" type="ORF">CGC21_11430</name>
        <name evidence="13" type="ORF">LDBPK_311640</name>
        <name evidence="11" type="ORF">LdCL_310023500</name>
        <name evidence="12" type="ORF">LDHU3_31.2850</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863255.1">
        <property type="nucleotide sequence ID" value="XM_003863207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4K3"/>
    <dbReference type="SMR" id="A0A3S7X4K3"/>
    <dbReference type="GeneID" id="13389429"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2850"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5432586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ36566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP41454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="271" mass="29460" checksum="E91D7000A8735807" modified="2019-05-08" version="1">MFTLVGVGLGDASDVTVKGMNAVKEADVVFLEAYTSFLINSNAEELAGIYGKPVILADREMVESGAVLDDAKVKKVVLLVVGDVFGATTHSDLIVRCNRQGIESKVVHNASIINAVGCCGLQLYRFGQVISLCFWTETWRPDSWYERLRSNRAAGIHTLVLLDIKVKEISDENLARGRKIYEPPRYMTIRQAVEQILEVEGYKQGGAVAADGSTFAVGLARVGSESQQVVAGTMKDLLSVDFGAPLHSLVIAGDVHDCEQEHVDLFRMAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5M8</accession>
    <accession>E9BNX7</accession>
    <name>A0A3S7X5M8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_322250</name>
        <name evidence="2" type="ORF">LdCL_320027900</name>
        <name evidence="3" type="ORF">LDHU3_32.2810</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863639.1">
        <property type="nucleotide sequence ID" value="XM_003863591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5M8"/>
    <dbReference type="GeneID" id="13390927"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2810"/>
    <dbReference type="OMA" id="MSIFAYY"/>
    <dbReference type="OrthoDB" id="271109at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="501" mass="56850" checksum="66B2308D311ECD81" modified="2019-05-08" version="1">MQTGSDVFMNIILATLKASNELVDGEIFELVSGSPALLKVFLDSGRVDIDDPRVQSVVQAKLDEVLAGDPYDGDVVSGDLLNYVRSLCSIRTSRITFQQMVLLRYSGFDYVELLIDYPYLLENLEKPSFCIFFVFDVLHYISIAISWIGVLVTLTFTAMVLWSVVFWFQQPEHRNNGYWIIITYVGGYVVSLVATMRAEEGKIKRYENQVWRYPDNLFRIVPIIPVYEIMLSYVLLRYEISANAKSFFIIRYDLRNGTLVQHITNGCFYALPQMILQTFLFISDIRRNHRYLHGACYWLLLGCSLTLITMSIFAYHRIAFFTHSCNGCGFAVLSSQSISAKDHTRVLARRVHPSDIVTKVFVFFTIYFFVAQTVTLVVLILNLHSCAGTAIIFPAIYMSVLGLSIIVIVVVCVNLPFSRGMGAIGIPVMLMQIAFLVYVNVGAASRECVIFKPSFSKWMIPSIAIFGLMCLSIVAWLTMLLVEFFRGVRITQRAVDHYVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X678</accession>
    <accession>E9BPC7</accession>
    <name>A0A3S7X678_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_21370</name>
        <name evidence="3" type="ORF">LDBPK_323770</name>
        <name evidence="2" type="ORF">LdCL_320043700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863788.1">
        <property type="nucleotide sequence ID" value="XM_003863740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X678"/>
    <dbReference type="GeneID" id="13391551"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320043700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4770"/>
    <dbReference type="OMA" id="IPMPQWA"/>
    <dbReference type="OrthoDB" id="238073at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="147" mass="16754" checksum="8092634CE5F89AEC" modified="2019-05-08" version="1">MAPPKASLPARIFAGDFMGINWNRVSWMAPYNNFYPITMCGGWGGRMWSSFIQYGRFDNRAGLIMVRNLIMGIPTALMALLMLGNMDWYQCMQCAFYLPGIAMPQWAQNEYAKEMEWASWNKPGAMAKHHYAGTVSIPGTEKYITEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6A1</accession>
    <name>A0A3S7X6A1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD domain, G-beta repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_320045700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6A1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320045700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5100"/>
    <dbReference type="OrthoDB" id="276661at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38806" checksum="F9FBBE0B2D259363" modified="2019-05-08" version="1">MFYTGINEPRPTAMNFSFDGLHFVSAHTDDAVRLIDVGNMTNTDVIICDAFGVHNVRYTHSSSVVCVAPRFHLDGHLHLLNTETSQFFGEMAYINDAESEMLPVANTPVYSTLAQCPATDVLGAVVVAKGRLALFHPLISGCIAATPERSIVGSRACLQFSQDGHRIAIGDDHRIVLFDRRSLFRAPLAVLENKHVFTTSTSLTRCKGLEFSADASRLLLTSSSGEVVVYDWLRGEAVANYFHGDARRHFVGSADAIGAQHAFPYQAASPILQLTSSMTGGRHLLVYAGCASNSAASTRQGRLLYELQSKDSDVPVAIAVNPRLQLAATAARSITWWAFHSSVVEAYATLTEAGTTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7I5</accession>
    <name>A0A3S7X7I5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340011800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7I5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1030"/>
    <dbReference type="OrthoDB" id="206339at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="91131" checksum="57BB0ECAB670A352" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X839</accession>
    <name>A0A3S7X839_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_340033900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X839"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4280"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000007">
        <property type="entry name" value="Signal recognition particle protein SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="602" mass="67037" checksum="0487BE124BFCCB13" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8N9</accession>
    <accession>E9BRM0</accession>
    <name>A0A3S7X8N9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_27385</name>
        <name evidence="2" type="ORF">LDBPK_344210</name>
        <name evidence="1" type="ORF">LdCL_340052200</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864581.1">
        <property type="nucleotide sequence ID" value="XM_003864533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8N9"/>
    <dbReference type="GeneID" id="13387459"/>
    <dbReference type="KEGG" id="ldo:LDBPK_344210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_344210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340052200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6590"/>
    <dbReference type="OMA" id="VHEIKLF"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="325" mass="34987" checksum="B9DAA6278301BD84" modified="2019-05-08" version="1">MSLDIATYQLLDADHHIHFCSQSPDTKFLACALGNGVVCLVNAITFNAVARGAPGKDFLDVPATCIRWAPEQCDSAWQLVSSSCAGGVMLWHWDRNEFSLRRGAAACEKHNEVMVVDVSPSGKQVLTAGSDRIVRLYDSKLTPLAQLTEGVNADGTSRPAHTNRIFSLRFLTEVAAVSAGWESPIQLWDLRACRSNRQVVGVQGVSDCLEPVPSTPIVLVASPKSTNTLQIFDTVTGRVLEENSNKMCSQLNVAERVLVCRIQGETGNAWCLTVSPPSVIVLCVSSGLIVARAALAHTPINMTMKDASVVVGCKNGVLLQVSLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8W0</accession>
    <accession>E9BRU8</accession>
    <name>A0A3S7X8W0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase subunit D family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Vacuolar ATP synthase subunit d, putative</fullName>
            <ecNumber evidence="4">3.6.3.14</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Vacuolar_ATP_synthase_subunit_d_putative/GeneDB:L mjF.35.0700</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_0630</name>
        <name evidence="7" type="ORF">CGC21_5910</name>
        <name evidence="6" type="ORF">LDBPK_350710</name>
        <name evidence="4" type="ORF">LdCL_350011800</name>
        <name evidence="5" type="ORF">LDHU3_35.0830</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="4"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864659.1">
        <property type="nucleotide sequence ID" value="XM_003864611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8W0"/>
    <dbReference type="SMR" id="A0A3S7X8W0"/>
    <dbReference type="GeneID" id="13387537"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0830"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000015">
        <property type="entry name" value="Vacuolar ATP synthase subunit d, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ37977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="276" mass="30569" checksum="5A1374A05BE0D8AC" modified="2019-05-08" version="1">MSSTSRYPALPSRMSLIAFKTRLKGAQKGHSLLKKKADALALRYRTVMGELRTAKLEMANQIKGSYFTITQAQFIAGDISLAVQESLKIPTYRMELQVENIAGVQVPSFHTQNDDAVDSQSDAATESRLKYGNPYSTGAVTGSLTAGLGKGGEQIKEAYSAFRHTLSLLVKIASLQTSWITLDIAQKVTNRRVNALEKVVIPRVQNTLSYITSELDEQEREEFFRLKMVQKKKVTAKIQQTARQAETAGIEAERTRKRNLLIAQRDGGVAEADMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8W7</accession>
    <accession>E9BRW7</accession>
    <name>A0A3S7X8W7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_0555</name>
        <name evidence="5" type="ORF">CGC21_5995</name>
        <name evidence="4" type="ORF">LDBPK_350910</name>
        <name evidence="2" type="ORF">LdCL_350013900</name>
        <name evidence="3" type="ORF">LDHU3_35.1100</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864677.1">
        <property type="nucleotide sequence ID" value="XM_003864629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8W7"/>
    <dbReference type="GeneID" id="13387556"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1100"/>
    <dbReference type="OMA" id="AVLQCYQ"/>
    <dbReference type="OrthoDB" id="241113at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="165" mass="17961" checksum="96BAE7F4B6701C0C" modified="2019-05-08" version="1">MFSSHKTPAKAQRDGYDDEQHLVAAVSEFKKVEASNQSMVDQLHQRLASPFQITTKPCEAGRAAVLQCYQQLQSSSAITTSKAASSASPAPPLGARSDSKSSNVAPAEAWLSIPYQQCYETALAYHQCVEDTLAKHLALVAVFEQRGTQQKIAHQSVMKAQDKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9K6</accession>
    <name>A0A3S7X9K6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_350039300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with poly(A) polymerase catalytic subunit OPG063. Interacts with OPG109 and OPG123; these interactions might help linking transcription to capping and polyadenylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="2"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9K6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4510"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20760">
        <property type="entry name" value="capping_2-OMTase_Mimiviridae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000176">
        <property type="entry name" value="mRNA_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025804">
        <property type="entry name" value="Pox/kineto_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01358">
        <property type="entry name" value="PARP_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51612">
        <property type="entry name" value="SAM_MT_2O_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="547" mass="61901" checksum="99EB288AC67532C8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAG9</accession>
    <name>A0A3S7XAG9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-repeat-containing chaperone protein DNAJ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360013100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAG9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1070"/>
    <dbReference type="OrthoDB" id="765884at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="774"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="850" mass="92009" checksum="7FB9A7D0F925D279" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAS0</accession>
    <name>A0A3S7XAS0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBF/Mak21 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_360025100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAS0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2560"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="340"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="633" mass="69987" checksum="6CD95114DEBE7CEC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB05</accession>
    <name>A0A3S7XB05_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar Member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360035700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4080"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2548"/>
            <end position="2567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2701" mass="295159" checksum="7DB577CC3F4DAFD0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBB1</accession>
    <name>A0A3S7XBB1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360044600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBB1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360044600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5070"/>
    <dbReference type="OrthoDB" id="272540at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="474" mass="52038" checksum="455C477D1777567B" modified="2019-05-08" version="1">MSIEKMFGTFCAMSALQQRRDGLLVPSETSHSFSYYQWLEVAKAKYADSQPRACSSPGQQRPPAKRAKTEDGVSDSGSALADGLAQQLVASLKSQTEFANSPAALRHAAQEEFPMPQASADMPAFLALAEAAIRLTLWTPEDERLAQLAARLRPNLRTLEERGIIRFYYGCFPSLQVLMDLLSWRIIVHRWERLTPEMRQIAVDGVLTLCGCLDSVATEALRAAVQELPVSAASSSSADTLELRTLDTLVRHVSAAVPFQFATCRDLAPLYPEPAGLLHVPGAPAASSESVLRDEQQSRPADEKRFDYDAEVQVGERLGVTCTPTLTVHASVEEESPARRTQAAPVAALPSRPILKAARRTSGGLRPSAGVTQIRHGIPTRTASGHIACMSQYHARYADPAKHASSECPYCATCHLMEIIFRGNKRSCLWGHWPTPRKIRLHLKQFPKVMKLAQERFAAIQRGVHLAATDEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC20</accession>
    <name>A0A3S7XC20_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_19125</name>
        <name evidence="2" type="ORF">LdCL_360070500</name>
        <name evidence="3" type="ORF">LDHU3_36.8360</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC20"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360070500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8360"/>
    <dbReference type="OrthoDB" id="247165at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="331" mass="38553" checksum="F318F271B1165505" modified="2019-05-08" version="1">MLQCTALVLKSQHKNVLRKGRPHMQKYKELNRWQREAQGITKWEQGHSHRPQPYVERFNPEGAGLTRGTSAYAWKWWHTQYPWLPNVAPADYVPPSPRGIRPAAWDDEFADVVLSMSDEEIQSYLLDKLTEVIFAETQRDGYELRRLDFEGKPLTELPERRIIENFVFEEETLRERVLDQVVEGVFRLVPTSADRLELKSVANIIDFVLTHVTVARKPVQLEIPEAARAVMRSHPLQPQLGFVHALPTDNRDAVVQEWERMHHLDWQFGKAVYEPRSVENERGNLTWLREVRHHEAREAFQADVDSGEARRRHMEKIKAAAQVPHTDTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC58</accession>
    <name>A0A3S7XC58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360072100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC58"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360072100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8560"/>
    <dbReference type="OrthoDB" id="273567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1093" mass="116480" checksum="02D8AFDC1F88B3A2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJI0</accession>
    <name>A0A451EJI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_020009600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJI0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020009600"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17000" checksum="72C36BF34BD73D5E" modified="2019-05-08" version="1">MTLKTQRDATALPQRDQPQRCTVPPPPSQQQQHFLIRSGIREDAAREVLDAAFLRGVPPSLPSTAVEHSNEHLSPDVPVVGVGSLTAARGDCLTAIIHHTESPSAVAHRKSKAEARAAPLHHGWGSRRDGGSDDDVAAMAEEMRRSEGGDPPNDEGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJQ6</accession>
    <name>A0A451EJQ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030010400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0550"/>
    <dbReference type="OrthoDB" id="267501at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF4">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1446" mass="154415" checksum="A348254C102482D8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7E1</accession>
    <accession>A0A3S5H4W9</accession>
    <name>E9B7E1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_010770</name>
        <name evidence="11" type="ORF">LdCL_010012700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857890.1">
        <property type="nucleotide sequence ID" value="XM_003857842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13389736"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0870"/>
    <dbReference type="OMA" id="THQCLVM"/>
    <dbReference type="OrthoDB" id="267011at2759"/>
    <dbReference type="PhylomeDB" id="E9B7E1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="385"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1269"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1391"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1395"/>
            <end position="1411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU75588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ31164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1411" mass="151863" checksum="5C80193F8F9A6F7E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9B984</accession>
    <accession>A0A3S5H601</accession>
    <name>E9B984_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="10">PAGM</shortName>
            <ecNumber evidence="4 10">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_070930</name>
        <name evidence="17" type="ORF">LdCL_070014200</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 10"/>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858529.1">
        <property type="nucleotide sequence ID" value="XM_003858481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B984"/>
    <dbReference type="SMR" id="E9B984"/>
    <dbReference type="GeneID" id="13391845"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1110"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="PhylomeDB" id="E9B984"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000051">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="16">
        <location>
            <begin position="364"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="14">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="438"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="561"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="597" mass="65395" checksum="F262DC695F366EFA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BA10</accession>
    <accession>A0A3S7WQU0</accession>
    <name>E9BA10_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_091250</name>
        <name evidence="2" type="ORF">LdCL_090018900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858803.1">
        <property type="nucleotide sequence ID" value="XM_003858755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BA10"/>
    <dbReference type="GeneID" id="13392152"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1490"/>
    <dbReference type="OMA" id="MCHRLEA"/>
    <dbReference type="OrthoDB" id="266679at2759"/>
    <dbReference type="PhylomeDB" id="E9BA10"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="598" mass="63519" checksum="631C7911FD9FFBF8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD31</accession>
    <accession>A0A3S7WU93</accession>
    <name>E9BD31_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_170040</name>
        <name evidence="10" type="ORF">LdCL_170005400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859864.1">
        <property type="nucleotide sequence ID" value="XM_003859816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD31"/>
    <dbReference type="GeneID" id="13393322"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0060"/>
    <dbReference type="OMA" id="CLEHFTL"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="PhylomeDB" id="E9BD31"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463:SF74">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23474" checksum="E088DE4DE8DAB397" modified="2011-04-05" version="1">MYFVSPVPTRAHLLQREAITRGSVMQGNPHTKAAAAASAASVPAGSHDASCSNLSDYLNEDSVVGDLETYDVGEYHLTTCPICLEHFTLDNPAILLKCEHGFHLQCLESWRQRSSMCPMCFAPVVGDEGRLMSSCDVRRRRRMQLKPPSAPHHAPERNALITPTAAQQTPQSNCEVEHASEQDEEIEVIEVTSRKGSVHWVWSWLRECCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD51</accession>
    <accession>A0A3S7WUC4</accession>
    <name>E9BD51_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_170300</name>
        <name evidence="8" type="ORF">LdCL_170008500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859884.1">
        <property type="nucleotide sequence ID" value="XM_003859836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD51"/>
    <dbReference type="GeneID" id="13393302"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0570"/>
    <dbReference type="OMA" id="CMTADTG"/>
    <dbReference type="OrthoDB" id="270224at2759"/>
    <dbReference type="PhylomeDB" id="E9BD51"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="16"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="359" mass="39129" checksum="01B2E6935E255337" modified="2011-04-05" version="1">MTSATPRGQILANALEAVGNTPCIRLNRVPQKHGIQCEVVAKCEFFNPGGSVKDRIGKQMILDAEKNGTLKPGSVIVEATSGNTGIGLSMAAAIRGYHMVITMPKKMSHEKETTLQSLGAEVIRTETSLPHDHPDSLIGVARRLRDEKGYVLLDQYTNLSNPGAHYEFTGQEIYDQCGGKVDMVVICAGTGGTITGVAKKLKELIPEVIVVGVDPVGSIIADPEHPGEPVMYHVEGIGYDFVPDVCERKYVDRWVKTRDQESFDLALELHREEGLLVGGSSGSAMAGVVEAAKDLRSDQRCVVLMADGIRNYMGKFADVNWMIEHGFRQGEVTRPTYDTLKKELEEVKAKLAKYESGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDE6</accession>
    <accession>A0A3Q8ICW1</accession>
    <name>E9BDE6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_171240</name>
        <name evidence="4" type="ORF">LdCL_170018600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859979.1">
        <property type="nucleotide sequence ID" value="XM_003859931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13393258"/>
    <dbReference type="KEGG" id="ldo:LDBPK_171240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1740"/>
    <dbReference type="OMA" id="EPELMWI"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="PhylomeDB" id="E9BDE6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="734"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="806"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1396" mass="149601" checksum="D7BBAEF0C77C8B1D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE05</accession>
    <accession>A0A3Q8ID71</accession>
    <name>E9BE05_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fibrillarin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_190090</name>
        <name evidence="11" type="ORF">LdCL_190005900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860188.1">
        <property type="nucleotide sequence ID" value="XM_003860140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BE05"/>
    <dbReference type="GeneID" id="13386000"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0100"/>
    <dbReference type="OMA" id="HARFNGC"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="PhylomeDB" id="E9BE05"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000677">
        <property type="entry name" value="Fibrillarin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="299" mass="31343" checksum="EE65A9FA13E7D7B7" modified="2011-04-05" version="1">MRGGRGGFGGRGGGGRGGGGRGGGGRGGGRGGGRGSGRGGGRGSGRGGGRGGRGGAGTPKGNIFHPHARFNGCYLLAGKDTLSTRSLVPGVSVYSEKRVNGTVAGESESHEFRVWNPYRSKLASAIYAGVASIYMEPGSAVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLEEMTKRRSNIVPILEDARYPQKYRMLIPRLVDCIFMDVAQPDQARILALNAQHFLKANGGFVISIKANCIDSTADPAAVFASEVQKLKDSGLRPKEQVSLEPFERDHCVVTGYYKNVPQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEG6</accession>
    <accession>A0A3S5H780</accession>
    <name>E9BEG6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_200190</name>
        <name evidence="1" type="ORF">LdCL_200006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860359.1">
        <property type="nucleotide sequence ID" value="XM_003860311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEG6"/>
    <dbReference type="GeneID" id="13386323"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0200"/>
    <dbReference type="OMA" id="EFLYVAY"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="PhylomeDB" id="E9BEG6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37761" checksum="201A38EC7DAB164E" modified="2011-04-05" version="1">MICRRLRCTPLSSAAVMFPDVAGTWDAVTTLDFSRTYVGSHGALSVIELCRCLPRLQSLVFCDNYLSNDTVWYLVQMALFHPSLERVDLSANEYISWSGAMCLVELVLRNPRIIYVGLRGSAVSTEIARCIEAQTRQNAVSRFRSEGMKRSPPVHPAAVYIRSLKHLFETHQQHGQVSASLLDSGFEELLRVSGRTGELHLFTEKHFSKLKARAPPGGLTCEAFLVLLLIDGSTYDETTVATLKRVFTMFNMDPSVPDPISDGYVLGRDMADMMTHVYGSRPSDTDVTALQRRLGATADTTTLDWEEFLYVAYPHGPKTGDRLCGLTCTPLASPIEAMHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BF38</accession>
    <accession>A0A3Q8IF27</accession>
    <name>E9BF38_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_210530</name>
        <name evidence="8" type="ORF">LdCL_210010100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860570.1">
        <property type="nucleotide sequence ID" value="XM_003860522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BF38"/>
    <dbReference type="GeneID" id="13386362"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0570"/>
    <dbReference type="OMA" id="YERVQFC"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="PhylomeDB" id="E9BF38"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000012">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1011" mass="111415" checksum="8DE52E29D3CC1493" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFA8</accession>
    <accession>A0A3S7WWJ9</accession>
    <name>E9BFA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Intraflagellar transport protein 172, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_211220</name>
        <name evidence="11" type="ORF">LdCL_210017300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860639.1">
        <property type="nucleotide sequence ID" value="XM_003860591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13386498"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1450"/>
    <dbReference type="OMA" id="LKRTIWQ"/>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="PhylomeDB" id="E9BFA8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000020">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000022">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001213">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003404">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="671"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1800" mass="199898" checksum="19C9BA4F71CBE464" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>E9BI96</accession>
    <accession>A0A3Q8IGZ0</accession>
    <name>E9BI96_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S16, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">40S_ribosomal_protein_S16_putative/GeneDB:LmjF.26.0880/GeneDB:LmjF.26.0890</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S9/S16 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_4945</name>
        <name evidence="10" type="ORF">CGC21_31780</name>
        <name evidence="11" type="ORF">CGC21_31785</name>
        <name evidence="8" type="ORF">LDBPK_260840</name>
        <name evidence="9" type="ORF">LDBPK_260850</name>
        <name evidence="5" type="ORF">LdCL_260014100</name>
        <name evidence="6" type="ORF">LdCL_260014200</name>
        <name evidence="7" type="ORF">LDHU3_26.1100</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="18" key="5">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="5 14" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="10">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861671.1">
        <property type="nucleotide sequence ID" value="XM_003861623.1"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="AK=1-149"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="L=1-149"/>
    </dbReference>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ1"/>
    <dbReference type="AlphaFoldDB" id="E9BI96"/>
    <dbReference type="EMDB" id="EMD-7024"/>
    <dbReference type="SMR" id="E9BI96"/>
    <dbReference type="GeneID" id="13388917"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260840"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1100"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="259783at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000093">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5430922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP41126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6AZ1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16688" checksum="73E8D22CE06D132A" modified="2011-04-05" version="1">MPADKSYALKQVQTFGKKKTAIAVATVTKAAQCNIKVNGVPLQQILPDTLRAKIMEAITVVGSKYYSRLRIDVAVHGGGQVSQAYAARQAIAKGLIAFFQKYHNEVEKAALKDKFLAYDKFLLIADPRRCEPKKWGRHSARTRFTKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJS4</accession>
    <accession>A0A3Q8IEX8</accession>
    <name>E9BJS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p21-C-terminal region-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_282030</name>
        <name evidence="3" type="ORF">LdCL_280025400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862302.1">
        <property type="nucleotide sequence ID" value="XM_003862254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJS4"/>
    <dbReference type="GeneID" id="13387038"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2680"/>
    <dbReference type="OMA" id="MPKRHRQ"/>
    <dbReference type="OrthoDB" id="278226at2759"/>
    <dbReference type="PhylomeDB" id="E9BJS4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="677" mass="73018" checksum="22869083FE3F1CA7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKM6</accession>
    <accession>A0A3S7X2B4</accession>
    <name>E9BKM6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_290800</name>
        <name evidence="3" type="ORF">LdCL_290012800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862497.1">
        <property type="nucleotide sequence ID" value="XM_003862449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKM6"/>
    <dbReference type="GeneID" id="13387236"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1090"/>
    <dbReference type="OMA" id="ACKARQF"/>
    <dbReference type="OrthoDB" id="264281at2759"/>
    <dbReference type="PhylomeDB" id="E9BKM6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21415" checksum="0283DBBBB2BD8061" modified="2011-04-05" version="1">MASHDGISDFSSSSAGDAVKSARVTTDSVQGLLRAARQNPEKELGIPLDELERRQREACKARQFVSESTSRKFDVKSSARAQQIMNQGVDKYQREKRQRDLRHNLSMLRKLQVVLCVFGAGLFGWLAVTYLLPRYFAVQDRQRRMQLRYERAQRSLEGIGDGGAAAAPVGPVVRVFRVEDGGEGSMKRTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ58</accession>
    <accession>A0A3Q8IGJ8</accession>
    <name>E9BQ58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_331270</name>
        <name evidence="2" type="ORF">LdCL_330018900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863953.1">
        <property type="nucleotide sequence ID" value="XM_003863905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ58"/>
    <dbReference type="GeneID" id="13392348"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1920"/>
    <dbReference type="OMA" id="LEHYNTV"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ58"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="346" mass="39247" checksum="313125EFBDCA8F4E" modified="2011-04-05" version="1">MSNTTSWQKAMIFASKGRMVGYRLTLEHYNTVLYSQSMWGRALEMIKVIRAMQQDGVQPNGATYYYIVNGMANAEHGYNYDFNINHRLEKLQHWRVALNALQACEANGFDSTDTMHNSVIVTMTIPGMNHWKEALQVLKKIIDEDRQLHPSMVRFLHDCLIRNYRPREASDLLRRAAERGVKGYESAWETDVYKGKPTDAQLEASQAEAAVTAAAGTECVAGSSGALSSLTSDCKEATRNSAQASAAATLMALQLRGDQALPPPQMRSALQEEMERNITAERQALRPFTAGLHYTEMRSVFRPRVHRQLWYQWHQIANRYRPTASLKRRQLAPRDSPTGIPAWNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9B7</accession>
    <name>A0A3Q8I9B7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_120013000</name>
        <name evidence="2" type="ORF">LdCL_120013400</name>
        <name evidence="3" type="ORF">LdCL_120013900</name>
        <name evidence="4" type="ORF">LdCL_120014400</name>
        <name evidence="5" type="ORF">LdCL_120014900</name>
        <name evidence="6" type="ORF">LdCL_120015400</name>
        <name evidence="7" type="ORF">LdCL_120015900</name>
        <name evidence="8" type="ORF">LdCL_120016400</name>
        <name evidence="9" type="ORF">LdCL_120016900</name>
        <name evidence="10" type="ORF">LdCL_120017400</name>
    </gene>
    <organism evidence="1 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9B7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120017400"/>
    <dbReference type="OrthoDB" id="267189at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16166" checksum="B33F6BE4193C5AD2" modified="2019-04-10" version="1">MGAGVVRLPHPRHGRALLCFVVRDPVVCAVARPRTPTLPCPAYASSPLLWEVRAHAPPSGFARSWLVKGRAVPSTVGAGELLAARSLDLTFSALHELLGDAQRCDRVARTFMPAAGLHRAGGMAFSARATATAAGCEAAAPVARTGGRRGPRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9K2</accession>
    <name>A0A3Q8I9K2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_130012200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9K2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0870"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="73573" checksum="56C99ED3A83C89C8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9P8</accession>
    <accession>E9BBR0</accession>
    <name>A0A3Q8I9P8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_38825</name>
        <name evidence="5" type="ORF">CGC21_4535</name>
        <name evidence="4" type="ORF">LDBPK_140250</name>
        <name evidence="2" type="ORF">LdCL_140007500</name>
        <name evidence="3" type="ORF">LDHU3_14.0330</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859397.1">
        <property type="nucleotide sequence ID" value="XM_003859349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9P8"/>
    <dbReference type="GeneID" id="13391089"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0330"/>
    <dbReference type="OMA" id="YTVMVES"/>
    <dbReference type="OrthoDB" id="269298at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="172" mass="19977" checksum="AD1A65915B0A6B24" modified="2019-04-10" version="1">MAPKAHSDEALLDACINANRLEYPEQSLIFVALIASFQPVYFSHAINGFDWRHVPNLVLYIVITGFTTYMLRQAYVVMVQSEFWGRQRHFAEVSDEKAKALRRLRLQVAVGYSLFFLNSVFFVVSTCLMAYIFRHSDPRASYILSPTLTAALLWLIAQKNEESRQRRMRLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBQ0</accession>
    <name>A0A3Q8IBQ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_200018500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBQ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200018500"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12971" checksum="F75F70E0DC6FB5E9" modified="2019-04-10" version="1">MASVLLQLQGIGEAPESALPSVSSRILQMRACRPDVMVAMYAVPHAAVGQAVRWHLRPGDTFLVKGEWEMWMKKLYARALTAQDRAVPSLNTVTTVAPRPCTADTETARTGVPRRCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBZ1</accession>
    <name>A0A3Q8IBZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210017100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1430"/>
    <dbReference type="OrthoDB" id="267521at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1443" mass="151420" checksum="638019260F4C3303" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICP8</accession>
    <name>A0A3Q8ICP8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260012600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICP8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0900"/>
    <dbReference type="OrthoDB" id="273435at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1090" mass="115868" checksum="43F63743E138BA7A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDE7</accession>
    <name>A0A3Q8IDE7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150013800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1080"/>
    <dbReference type="OrthoDB" id="273212at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2162"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2201"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2162"/>
            <end position="2172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2285" mass="240675" checksum="B062F8313D32F6BF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDJ8</accession>
    <accession>E9BI78</accession>
    <name>A0A3Q8IDJ8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_260650</name>
        <name evidence="10" type="ORF">LdCL_260012200</name>
        <name evidence="11" type="ORF">LDHU3_26.0860</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861653.1">
        <property type="nucleotide sequence ID" value="XM_003861605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDJ8"/>
    <dbReference type="GeneID" id="13388899"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0860"/>
    <dbReference type="OMA" id="KMSREWQ"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599595" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5430903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="225" mass="25669" checksum="A6F7B3419520B62B" modified="2019-04-10" version="1">MLRLTRLGLGAALLLVLFVVLSVSAEEGTVTYYGQLRLPPTYLRHPDCFEALNDIQPGSVLLYNGQHRFVVPTARDGSFSVYKLPYGTYILQAEYHYFMFPTVRVEVMYRDTGDDQKETFIRTSANDYPVRHLEGSGLDEESPAVIPFSGYHNYYIPRQQMDIVSLLKSPMVIMLLVSVSLMGLMKLFPEEEIRESQKMTREWQKKLVKSVSTDKTGAKLPTITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE06</accession>
    <name>A0A3Q8IE06_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330038200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330038200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4450"/>
    <dbReference type="OrthoDB" id="264159at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1480" mass="154802" checksum="10892D61A224B494" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE73</accession>
    <name>A0A3Q8IE73_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein, putative</fullName>
            <ecNumber evidence="3">3.6.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300019300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE73"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1790"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000123">
        <property type="entry name" value="GTPase activating protein, conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="93"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="607" mass="65324" checksum="095E2B3C279AEA4F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEH0</accession>
    <name>A0A3Q8IEH0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300035000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEH0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3900"/>
    <dbReference type="OrthoDB" id="273292at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="454" mass="49019" checksum="5B687F5158727B6A" modified="2019-04-10" version="1">MAALLLASRRHVFLYMDESMSAEEMLATTAEMQQVRESLFSFSTPLAVDAERARRTVGSSNGGASPLHMSCTLNALAHTDGEYEVLLAAVSREWAQQQERRSTQHPHGAATAPGDGEAGSVPLPGAFQRELEDARAAQRDAEDALADQRRAHRKEVLLLRAELESAQRSGDDTVVSEVPNGSTVNGRAVSQTFSHSLQQQQQHSHRHHSSDAESSAVVSQLQKALQDARKAQQFAEEKARLLELRQSLTSGSKGAPTGAGDASGAVTSPRPSLRLQPSRATSIAALSPSAAAPPAWEQNLLKQENAALVAEFQRKERAWQQQLLQASAEAAQLKQERATMKATLQLQSQAIAAAQQALVDSRVAQEQEMKQLLERVRVLSQESRSRRRSQTQSADTDKTRGSHAGGDVPDAGVLSPSVRLSRPLQRQATPEPSPVGSPRPKTTASICGIMSPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEZ1</accession>
    <accession>E9BKH2</accession>
    <name>A0A3Q8IEZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-heme dioxygenase in morphine synthesis N-terminal protein family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Thymine-7-hydroxylase, putative</fullName>
            <ecNumber evidence="6">1.14.11.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_27675</name>
        <name evidence="7" type="ORF">LDBPK_290260</name>
        <name evidence="6" type="ORF">LdCL_290007400</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.6" evidence="6"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862443.1">
        <property type="nucleotide sequence ID" value="XM_003862395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEZ1"/>
    <dbReference type="SMR" id="A0A3Q8IEZ1"/>
    <dbReference type="GeneID" id="13387181"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0350"/>
    <dbReference type="OMA" id="FWHVGRE"/>
    <dbReference type="OrthoDB" id="256265at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050341">
        <property type="term" value="F:thymine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP52660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="319" mass="36407" checksum="7693AB28CB46FFA2" modified="2019-04-10" version="1">MPLPVIDIAPLYNDNKADLLRVAHAIDEACRTWGFFYITGHQIPKDRSEQLTKMANKFFALPQEEKLRINIEKTSNHRGYGTCAAEQLDPSKPGDWKETFDMGFHLPLDHPSVVAGKPLRGPNNHPTWIEGWTELMEQHYSDMQRLALLLLRALALALDIDEDFFVSKFHEPLSVFRMIRYPALPEEKGRVVCGAHTDYGIVTLLYQDKVGGLQVQNLQGEWMDAPSLEGSYVVNIGDMMAMWSNGRYKSTPHRVLNQGVERISMPFFCEPNPETTISCLPNCFDEANPSKFPDVKAADWLLKRFQQTYAYRADDLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF35</accession>
    <name>A0A3Q8IF35_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C5orf34-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330036000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF35"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4040"/>
    <dbReference type="OrthoDB" id="273397at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027865">
        <property type="entry name" value="C5orf34-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15016">
        <property type="entry name" value="C5orf34_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C5orf34-like C-terminal" evidence="2">
        <location>
            <begin position="794"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1089" mass="116127" checksum="82F8FF4FBA865E9F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFM1</accession>
    <name>A0A3Q8IFM1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_300008700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFM1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0500"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF178">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="642" mass="71316" checksum="2A618BF706382E4F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFS7</accession>
    <accession>E9BRB3</accession>
    <name>A0A3Q8IFS7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_26890</name>
        <name evidence="2" type="ORF">LDBPK_343150</name>
        <name evidence="1" type="ORF">LdCL_340040400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864474.1">
        <property type="nucleotide sequence ID" value="XM_003864426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFS7"/>
    <dbReference type="SMR" id="A0A3Q8IFS7"/>
    <dbReference type="GeneID" id="13387353"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340040400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5320"/>
    <dbReference type="OMA" id="HDSWCKQ"/>
    <dbReference type="OrthoDB" id="275709at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="150" mass="17502" checksum="7C88EFACF0CD19DC" modified="2019-04-10" version="1">MALSSSGSAALGNRIARATAAAPQWTVQQRCFRQLMKSLRGAYFHDRSKLFWARHRVLVEFYKYSRVEEEKDVLLLVGIGNEIATFVAEYMKVDVGAIMEHNEKIQSLPVAKAKKYREEYLLHEKQHESWCKQKIRLMMDRRPPPPYPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFW1</accession>
    <accession>E9BLV0</accession>
    <name>A0A3Q8IFW1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_35800</name>
        <name evidence="3" type="ORF">LDBPK_302070</name>
        <name evidence="2" type="ORF">LdCL_300026000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862919.1">
        <property type="nucleotide sequence ID" value="XM_003862871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFW1"/>
    <dbReference type="GeneID" id="13385627"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2810"/>
    <dbReference type="OMA" id="THRGVRM"/>
    <dbReference type="OrthoDB" id="271369at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="313" mass="35120" checksum="4F3876B484578B47" modified="2019-04-10" version="1">MKFTHREIEDDRRKPVGSLFMHLIDRDSMPSRSHRNAAAQKMNTHSLPNTELSLYAQDAPQISSTPVRGRRHFPKQDRHVDCNKAEEVRPSRGVRRGATANGSIDHIGGDMTPRASTEVSMPRQRRYVPPPARSSTHRPFWLGDDEIVASARCRRGAGSAARSVSVGSQSFSRNSSTADHLTVGSLVPLPEKPVEKPVPPPLPIKPRRKGVRMFPGLRSRSADNARRGIRMVQPQPHWRSAADRQWDFLELGVGRRETPAPLYRNESHIDVGGPIIVREGPSTPIQRWRGGRRYGGTPVRRTFDIITGRPLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFZ9</accession>
    <name>A0A3Q8IFZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-tail PG-rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350009300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFZ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0580"/>
    <dbReference type="OrthoDB" id="429991at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF28">
        <property type="entry name" value="BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="491" mass="52795" checksum="13B20F6DCBCB2306" modified="2019-04-10" version="1">MSSDRSGPAAKASAGQCSSDRPLAVAADPKQYSMALCPDTPSYSLCGRLKSEWDKQSAAASPGPAAYDVPGYFDTLDPQQQQRHLWSGPVPGVHLGIRTVLPESREKAGMPGPGAYHLVRFGDELPRTREPLITRSSRRGRGAAADTPGPGAYDDPTSIAYRADQVRRKRLFTQCSTFGGRWCRREFHTAGPGPAAYNTVAATKLLEKNQRHAPRLVRRQPPLDRQSVAEAAAARMKVPGAPTPQAFPSLPSDFDFDFRKGKTIGGRLHEPLARTAPSHLTQAADDKPSGSRAFWESPPPPGGRFAATPFDPQSHSLAAEKAGTNAARLSEAANCKPGPGSYNVEVDPTARRVPASLFGRTLSAKSVSAENGVPGPGHYRIVDETGSGGTIFYKGDFHPRGCSGQGGSAAENLGVGPGAHYNDDTMYSNSINGDRAHNKGFTMGIRYPARATYQHCAPYDETTNINCVYDDELNWVVRPNQHLPLIRRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG97</accession>
    <accession>E9BMK9</accession>
    <name>A0A3Q8IG97_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase (Class 3) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Lipase, putative</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Triacylglycerol lipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_11875</name>
        <name evidence="4" type="ORF">LDBPK_310860</name>
        <name evidence="3" type="ORF">LdCL_310014500</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863176.1">
        <property type="nucleotide sequence ID" value="XM_003863128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG97"/>
    <dbReference type="GeneID" id="13385897"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1280"/>
    <dbReference type="OMA" id="ETDINGW"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599604" evidence="1">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="308" mass="33192" checksum="401002ACC8AA859E" modified="2019-04-10" version="1">MPHSSCSRIVVVAALLLLCGSARAVVLSREYSQTDARRSLQYANVTYADIDAIESWKCGGSCNANPSFKVTSIVKGDDAHSLLAYVGVDDGSAQVVVALRGSATQQEKLMRRPAEPVLYDITSGCGLECRVHTGFQRSYLAVRRTVRAAVVRDLTMHPGYNVLVTGHSVGAAVALLAAVDVQAHVNRMFFVSRPIVSLYTFGMPRVGNQAFAVWAAGMLSRGSHFRITSRHDPVPRMPSSGSADFQHVPYEVYCAAAAGTNCRVCEDSADGDDPTCIVQASKVDMRDHFFYFGERISGGAAGDAMLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGK7</accession>
    <accession>E9BPE2</accession>
    <name>A0A3Q8IGK7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetoplast-associated protein p18-2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Kinetoplast-associated_protein_p18-2_putative/Gen eDB:LmjF.32.3770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_35235</name>
        <name evidence="5" type="ORF">CGC21_21440</name>
        <name evidence="4" type="ORF">LDBPK_323920</name>
        <name evidence="2" type="ORF">LdCL_320045200</name>
        <name evidence="3" type="ORF">LDHU3_32.5050</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863803.1">
        <property type="nucleotide sequence ID" value="XM_003863755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGK7"/>
    <dbReference type="SMR" id="A0A3Q8IGK7"/>
    <dbReference type="GeneID" id="13391566"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320045200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5050"/>
    <dbReference type="OMA" id="AAKMYRR"/>
    <dbReference type="OrthoDB" id="272913at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052695">
        <property type="entry name" value="Kinetoplast-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564:SF4">
        <property type="entry name" value="DNA-ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564">
        <property type="entry name" value="KINETOPLAST DNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="132" mass="15005" checksum="987B7CF6A577C491" modified="2019-04-10" version="1">MLRRSHVLLRVSPFALFVQDVGKTGKLKGAKNACETAAKMYWKLSPAEKSALTRRAKKKTFPLQEAYQRMAKRKMRRLRDMPISKRQEHIRAKWTSMRGSQASKPTNTVPSAKAKVKATRKAGKKIAKGPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHC5</accession>
    <accession>E9BPX6</accession>
    <name>A0A3Q8IHC5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_38350</name>
        <name evidence="3" type="ORF">LDBPK_330470</name>
        <name evidence="2" type="ORF">LdCL_330010200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863871.1">
        <property type="nucleotide sequence ID" value="XM_003863823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHC5"/>
    <dbReference type="GeneID" id="13392268"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0720"/>
    <dbReference type="OMA" id="VFATHRC"/>
    <dbReference type="OrthoDB" id="264016at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="288" mass="32236" checksum="B9CCABA5E675C222" modified="2019-04-10" version="1">MHQLRTFNYVASELGHDEPVLHAVFATHRCLPPDPPEANFTTAIPQTVTAASRRESSDDASIGAAVHVEKTVALSVEDTLSAPLEVALTVEQELAQLSEKLDAWKVQRLADLQAPGGERSPSRLAQMEAAMERRLARRRIEEQDRAQKRVDALLSYLSPRIDKQLQLVAREHEGEEAPPSSNARVETTSDVKDSACADKSAASAATPSPPSPRARILCDQQHFAKRQEIALEERCARQAVLRNMWDARRLVHLVEDEVSFRHSIETREVLWRDRVHSELHASVEMDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIW9</accession>
    <name>A0A3Q8IIW9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_340046300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340046300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5940"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000006">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000884">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000008">
        <property type="entry name" value="Dynein heavy chain 10, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000025">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000013">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1937"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2216"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2565"/>
            <end position="2733"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2933"/>
            <end position="3090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3188"/>
            <end position="3269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3395"/>
            <end position="3461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3719"/>
            <end position="3753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU82736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4645" mass="528760" checksum="FD8222220095CEFB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ55</accession>
    <name>A0A3Q8IJ55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vps23 core domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_320016100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ55"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1380"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SB" evidence="8">
        <location>
            <begin position="274"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="409" mass="45098" checksum="55E13028380C2C74" modified="2019-04-10" version="1">MELTLHQAADISIVSQYYSPVAASAITYAISNFLPYANNFPNAKVRLTPGKDIAEPLHFECFLTIRKSPQDTQGTPLLVVISFADHYPQQTPSAVLVPPPGGEKIKHPYSVMSIDGRIQVECLSFLRGVVRPYSLLDMLLAISEQFELEYPLVGANYVPPTAAASDLLSAQSAELSDMDPARQSLVQEAAERVVIDVNQKASKYLDMREQALLYLQKLNESNRELQRAKEILTEHQDELQEYLPSVGNVSSLVRQLDGHEDTVEEHANCLVPADPLQARALELLAEIHAADDTLALLEEGLKRELMTCDDYVKNVSDVGREQFVSRHLYLKVSDKLGKTSSGAAATTPVSTPPPGQSPRSPPEVPQRLAPTEALRMEFPSADVDVIRDVLASVEGDLTIARQQLKMMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJE1</accession>
    <name>A0A3Q8IJE1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320029500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJE1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320029500"/>
    <dbReference type="OrthoDB" id="267976at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="930" mass="105502" checksum="A3016308526B2221" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJW8</accession>
    <name>A0A3Q8IJW8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">40S_ribosomal_protein_S18_putative/GeneDB:LmjF.36.0930</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">40S_ribosomal_protein_S18_putative/GeneDB:LmjF.36.0940</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S13/S18 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_29420</name>
        <name evidence="11" type="ORF">CGC20_29425</name>
        <name evidence="12" type="ORF">CGC21_12825</name>
        <name evidence="13" type="ORF">CGC21_12830</name>
        <name evidence="7" type="ORF">LdCL_360015100</name>
        <name evidence="8" type="ORF">LDHU3_36.1320</name>
        <name evidence="9" type="ORF">LDHU3_36.1330</name>
    </gene>
    <organism evidence="7 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJW8"/>
    <dbReference type="SMR" id="A0A3Q8IJW8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1330"/>
    <dbReference type="OrthoDB" id="256189at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP42343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP48215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP48216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="153" mass="17404" checksum="793CB20CFFAA1951" modified="2019-04-10" version="1">MSLTLIPDHFQHIVRLLNTNVEGKRKVPFALRMVKGVGIRFAYLVCKKAGIDVERRAGTLTAEELEKIAEIIADPAKFKIPDWFLNRQRDPKTGKTEHLSSSMVDTRLREDLERLKKIRAHRGVRHAYGLRVRGQHTCTTGRHGKTVGVSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL35</accession>
    <name>A0A3Q8IL35_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_320023500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL35"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2290"/>
    <dbReference type="OrthoDB" id="245242at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000013">
        <property type="entry name" value="DNA polymerase alpha/epsilon subunit B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="335"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="726" mass="77695" checksum="0BDB3B4B64B981DF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILI9</accession>
    <accession>E9BFS9</accession>
    <name>A0A3Q8ILI9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_16440</name>
        <name evidence="15" type="ORF">CGC21_2365</name>
        <name evidence="14" type="ORF">LDBPK_220600</name>
        <name evidence="12" type="ORF">LdCL_220013300</name>
        <name evidence="13" type="ORF">LDHU3_22.1030</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860810.1">
        <property type="nucleotide sequence ID" value="XM_003860762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILI9"/>
    <dbReference type="SMR" id="A0A3Q8ILI9"/>
    <dbReference type="GeneID" id="13389375"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1030"/>
    <dbReference type="OMA" id="KGPEMQK"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF131">
        <property type="entry name" value="B5 REDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="36"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5430041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP54076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="289" mass="32320" checksum="389C468D5FBB5BBE" modified="2019-04-10" version="1">MKAFIAVATGFVTSSWYNSVSSSSNCATPSSPFSQSEFRSFPLMDVYDESHNTKVFRFALPEADMPLNLEVASCVSFRFFDKDGKEVIRPYTPLNRSDQLGYFDVLVKKYQGSKMGTHLFSMKKGDTIDVKGPWMKLPIKANQYKMIGMIAGGTGITPMYQVARHVLHAPKNNTEITLIYANERKEDVLLGNELNELMETYPRFSPYFVLSKAPSDWMGGVGFVNKEMIKSLMPAPNRAGDSIILVCGPPPFMEAISGDKDFKSNPPSQGELKGCLKELGYMPKMVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INJ8</accession>
    <name>A0A3Q8INJ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340035600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INJ8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340035600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4740"/>
    <dbReference type="OrthoDB" id="271204at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="89" mass="10372" checksum="1F77D82A69794FE4" modified="2019-04-10" version="1">MLRLTRRSLMQRSRMTLEANFKSHSAAANPATDASVTGKVKAELKKMIKIQLVLIPICVVFMVWMYPTPTEEDERRMRLEYERNAGWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IP29</accession>
    <name>A0A3Q8IP29_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic cell cortex C-terminal pleckstrin homology, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_260014800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IP29"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1180"/>
    <dbReference type="OrthoDB" id="243853at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="444"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="613" mass="66873" checksum="B8845F008C57F488" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPM9</accession>
    <name>A0A3Q8IPM9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPM9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0230"/>
    <dbReference type="OrthoDB" id="238132at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20873" checksum="F171D7435E63A3BF" modified="2019-04-10" version="1">MLRSSLRYGVHKVGYTHPHHLPVPCAQRWDLRLARARIFQEYIEEKAPGAWQLEDERHMSPEFNTFTGYPMRNLRPGYGQNLPEFIMKKRLPNNTHYELFARRDIPNEDNAMYGKLLYDMTIHGTSLPSIYRMHKDINKAQRNDRKLSGNRFKVLNSSGAKSPPSGFEVIPDAVEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITD1</accession>
    <accession>E9BNX8</accession>
    <name>A0A3Q8ITD1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)_putative/Pfam:PF00076</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_34430</name>
        <name evidence="7" type="ORF">CGC21_20670</name>
        <name evidence="6" type="ORF">LDBPK_322260</name>
        <name evidence="4" type="ORF">LdCL_320028000</name>
        <name evidence="5" type="ORF">LDHU3_32.2820</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863640.1">
        <property type="nucleotide sequence ID" value="XM_003863592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITD1"/>
    <dbReference type="GeneID" id="13390928"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2820"/>
    <dbReference type="OMA" id="RETMQFP"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF13">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="404" mass="43828" checksum="C3CD0A6373B4747D" modified="2019-04-10" version="1">MEDRNSVASSVFFTGVSLVIEKEKLRQHFESVGHVVSFTIFGPAPGKDFRYGIAGYMDEKTAEEAIRRLDGTTFGERAMRVTAARSTTLHGPLRAGPGGGGSGPADHSTFRKRPREPYPSPNSSRPPYGSGMGRGGGMRAPMARVPFSSQPQQKQEQSQQLTTDKAGRETMQFPRFYTDPILGRDGSLVLDALRGMATEEAYSAVEQLRVLALERPNEAKRLLHNNPALKSAVIMTLQHAGRIPLGSLPRAAYQSRRAAEAEAELAQPLSPQQPTPSHQPPLPTPQQTPQQPPAESPTPAKKEAKSAAKSGEARGARKRDTATESASSSAAAPSGSQTSLVPPSTPMTEAERDEVLELIQSMSEEDVERVLTMSARDFAQVPDPAQRKQLEVLQKRLLEMSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IV00</accession>
    <name>A0A3Q8IV00_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_350007300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IV00"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0310"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39907" checksum="BA719CAB960B1AE5" modified="2019-04-10" version="1">MMPLSIHARTFVPSSTTYSPSGANEQTVHAADSKDCVCIAFYENGKCPYGSHCEHAHRFSELNTETQMKLLRSVPVESIPAHFFGASHSRDEMLAALNAVLPRTLTAEYGCFSPIHRGEAERTVSTRRRPPGKDRQLVVPHIGPQSPTLNAASLSSRTSSSSESLHVGGKHLSKCSSSPTAAAFAAAAAPTAADAAAFKMHLPLRCRYPHRSIPGTYYDVLALPRDASQDDIIAKYRSWQKDGFKRMRQVDPVGAEAVDRMIVEARNVLGNPILRSDYDQQLPSAPMKQQPWSAASCGAGLTSTSTTPSKHHTQGQSSTTSSTSEVHHRLGESHKLLGHSRSNSSVYYADYAAPVVTISSLHNGESIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVH8</accession>
    <accession>E9BST0</accession>
    <name>A0A3Q8IVH8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_354100</name>
        <name evidence="1" type="ORF">LdCL_350046100</name>
        <name evidence="2" type="ORF">LDHU3_35.5320</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864988.1">
        <property type="nucleotide sequence ID" value="XM_003864940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVH8"/>
    <dbReference type="GeneID" id="13387866"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350046100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5320"/>
    <dbReference type="OMA" id="NAVQVHY"/>
    <dbReference type="OrthoDB" id="271738at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12518" checksum="5968C8857D0FDD07" modified="2019-04-10" version="1">MTTSTPSAAAAGFKERTEADMALRFLNHCLSNAVQVHYLVISSLRGGDWKTSTLLEAEAQAYMRALLAVYAASSGFRRQLVSGDSLYYLQCLTDEATRTDFVRVAAAPSFPFACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4T2</accession>
    <accession>E9B776</accession>
    <name>A0A3S5H4T2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_18030</name>
        <name evidence="4" type="ORF">LDBPK_010120</name>
        <name evidence="2" type="ORF">LdCL_010006200</name>
        <name evidence="3" type="ORF">LDHU3_01.0140</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812621">
        <property type="protein sequence ID" value="CAC5426886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000041">
        <property type="protein sequence ID" value="TPP54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857825.1">
        <property type="nucleotide sequence ID" value="XM_003857777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4T2"/>
    <dbReference type="GeneID" id="13389749"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0140"/>
    <dbReference type="OMA" id="ANTYQYA"/>
    <dbReference type="OrthoDB" id="273915at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5426886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="657" mass="70092" checksum="05E81CAAC9583C11" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H514</accession>
    <name>A0A3S5H514_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="5">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_020012100</name>
        <name evidence="8" type="ORF">LDHU3_02.0820</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5427027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H514"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0820"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000705">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="6">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5427027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21550" checksum="5831BB82232422C3" modified="2019-04-10" version="1">MGTDNVPSSSVEAVQRCLQRLCQPIVFYSCDAAAPMTSAAGISPSFTTMPSTRALLVKPHSQSNFYAIDHVTAVHLLQEAVCERVVYSRYGVLGVRIMKLLLQHHFLEERTLAEQPIATYVKVREVLHQMFKDGFLLQQEVPRTSALVERSAKASVYLWGLSWSATLLPVVRERLAKTLTIAWAKLREAQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5D5</accession>
    <accession>E9B858</accession>
    <name>A0A3S5H5D5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase biogenesis protein Cmc1 like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase biogenesis protein Cmc1 like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_2895</name>
        <name evidence="2" type="ORF">LDBPK_040930</name>
        <name evidence="1" type="ORF">LdCL_040014900</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858155.1">
        <property type="nucleotide sequence ID" value="XM_003858107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5D5"/>
    <dbReference type="GeneID" id="13391003"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1170"/>
    <dbReference type="OMA" id="YIPRRAK"/>
    <dbReference type="OrthoDB" id="268516at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP51511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="148" mass="17234" checksum="750BD1C133F5C3BC" modified="2019-04-10" version="1">MSLYGARESGGDEMLTPGITGMSGNYRNESNCHRFWNRLMTCMRESQELDVLYDCRSRMLDMRECVVRHKQSTWVMRETMTSIRHEGELRKWLRDYDEKMGHPPLLEAVAAVRKKVDAEGGVDIMNPTVFKDPDMYIPRRVKVASADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5M0</accession>
    <accession>E9B8K0</accession>
    <name>A0A3S5H5M0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyltransferase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Nodulation protein S (NodS)/Methyltransferase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Nodulation_protein_S_(NodS)/Methyltransferase_dom ain_containing_protein_putative/Pfam:PF05401/Pfam:PF13847/P fam:PF12847/Pfam:PF08241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_24090</name>
        <name evidence="8" type="ORF">CGC21_9755</name>
        <name evidence="7" type="ORF">LDBPK_051100</name>
        <name evidence="5" type="ORF">LdCL_050016300</name>
        <name evidence="6" type="ORF">LDHU3_05.1230</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858297.1">
        <property type="nucleotide sequence ID" value="XM_003858249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5M0"/>
    <dbReference type="SMR" id="A0A3S5H5M0"/>
    <dbReference type="GeneID" id="13391626"/>
    <dbReference type="KEGG" id="ldo:LDBPK_051100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_051100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1230"/>
    <dbReference type="OMA" id="MSAFQTG"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000363">
        <property type="entry name" value="Methyltransferase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF74">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5427367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP51797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="245" mass="28132" checksum="7595B4A6E63B1970" modified="2019-04-10" version="1">MSKYANPEYWEDRYRSNDTTFDWFVTYDNLQTILRPLLQPAEQIRVLVVGCGNSRLSANLYEHLNIKKITNVDVSPTVISQMQRRYSEMNEMQWICADLLTTPIEKLMLELCPNDYLYDFIVDKGLVDSILGGSNSFHNLYTFNKNMSRLLKRGGRFVVVSYGSPETRMDHFRRKKLNFDVEHKLLEKPMLSSSTASPTGHYHVYIMVKVGAKQGVGVAVAAGDAESEDDDDFYDRFMTHNSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5N3</accession>
    <accession>E9B8M4</accession>
    <name>A0A3S5H5N3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_20285</name>
        <name evidence="6" type="ORF">CGC20_21700</name>
        <name evidence="8" type="ORF">CGC21_24490</name>
        <name evidence="5" type="ORF">LDBPK_060130</name>
        <name evidence="3" type="ORF">LdCL_060006200</name>
        <name evidence="4" type="ORF">LDHU3_06.0170</name>
    </gene>
    <organism evidence="3 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000055">
        <property type="protein sequence ID" value="TPP43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000054">
        <property type="protein sequence ID" value="TPP49815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858321.1">
        <property type="nucleotide sequence ID" value="XM_003858273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5N3"/>
    <dbReference type="SMR" id="A0A3S5H5N3"/>
    <dbReference type="GeneID" id="13391648"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0170"/>
    <dbReference type="OMA" id="WWPTSEH"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="186" mass="20848" checksum="186B02D3699E29C3" modified="2019-04-10" version="1">MPSSSKKQNVVTFSEVHDPLYGVLSPLSPSPLVVRHVQYPSLHHYFLCERFKGSPAEQWMAEATTVWSLERLVKTAEEEGYQRHNWNKVKVDVMLLGTYFKFKQNEAARAVLLSTQPSLLLYHTPTDDFWGDGGDGKGKNVLGVVNMAVRARLHSEEERQKQRPSASGRHSKSAAAKSTALPATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Z5</accession>
    <name>A0A3S5H5Z5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonyl-coa decarboxylase-like protein</fullName>
            <ecNumber evidence="3">4.1.1.9</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Malonyl-coa_decarboxylase-like_protein/GeneDB:Lmj F.07.0730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_070013000</name>
        <name evidence="4" type="ORF">LDHU3_07.0990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="4.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Z5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0990"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050080">
        <property type="term" value="F:malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.150">
        <property type="entry name" value="Malonyl-CoA decarboxylase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038917">
        <property type="entry name" value="Malonyl_CoA_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007956">
        <property type="entry name" value="Malonyl_CoA_deC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042303">
        <property type="entry name" value="Malonyl_CoA_deC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28641:SF1">
        <property type="entry name" value="MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05292">
        <property type="entry name" value="MCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="2">
        <location>
            <begin position="386"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA decarboxylase C-terminal" evidence="2">
        <location>
            <begin position="681"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="794" mass="85692" checksum="55A682254020B36A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7C4</accession>
    <accession>E9BGH9</accession>
    <name>A0A3S5H7C4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16910</name>
        <name evidence="4" type="ORF">LDBPK_231650</name>
        <name evidence="3" type="ORF">LdCL_230023700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861058.1">
        <property type="nucleotide sequence ID" value="XM_003861010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7C4"/>
    <dbReference type="GeneID" id="13390258"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2210"/>
    <dbReference type="OMA" id="YIHETAK"/>
    <dbReference type="OrthoDB" id="273237at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="165" mass="18210" checksum="FBE147D47413E5E3" modified="2019-04-10" version="1">MLSSASSASALWSACGIVALICAFATAVLCVTVWQLCGRVNVMQHGAVAIALIPISVFLGHVLCASYNALGETLQTFAKKNAQDLPQPLFYVIAAIRPLVAQVGLTDAMWMACLLFTAYSVTKVWHHLIDITRLLKASRRRLQLPEMRERRRQEEAANTKGQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7I3</accession>
    <name>A0A3S5H7I3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_270027600</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7I3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3110"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="465"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU80104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="791" mass="84893" checksum="E3AF9A3193C8F3C6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7M7</accession>
    <accession>E9BLK4</accession>
    <name>A0A3S5H7M7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carrier family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Mitochondrial_carrier_protein-like_protein/GeneDB:LmjF.30.1050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_7180</name>
        <name evidence="16" type="ORF">CGC21_35335</name>
        <name evidence="14" type="ORF">LDBPK_301110</name>
        <name evidence="12" type="ORF">LdCL_300016300</name>
        <name evidence="13" type="ORF">LDHU3_30.1440</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862824.1">
        <property type="nucleotide sequence ID" value="XM_003862776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7M7"/>
    <dbReference type="SMR" id="A0A3S5H7M7"/>
    <dbReference type="GeneID" id="13385531"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1440"/>
    <dbReference type="OMA" id="GFYDPMR"/>
    <dbReference type="OrthoDB" id="442325at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5432129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ36132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP45676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="338" mass="37275" checksum="0B8C3B675BF97EE7" modified="2019-04-10" version="1">MSTVDMYIDGAVASMCATIISNPFDVMRTRMQLQGELCKRGEYKVVYDNLGQGMIRVAREEGLRALQKGLVSSVMWQVMQNGIRVGLYPAARAEVSYVCGSDAVYISVIAGALCGLVGSYLSSPFQLVKTRLQSQRNTIVTMRGDVLSKATTGEQYDYAGVKDAFHKIYKTGGLRALWKGSHIAAQRTLVGSAAQLTAYDVAKPIICQRMGWPASDIRVHICAAIFSASCVMCVMNPLDVVMTRSFNHRIGEPMAYSTNLAVATWKIYRIEGVRGLYKGSMALFSRSAPHNIATFVMLEYLRKMRERYTNRAYTSGSSVDKSIGFNRVIDRKSGKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7N1</accession>
    <name>A0A3S5H7N1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300024800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7N1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2680"/>
    <dbReference type="OrthoDB" id="272086at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="440" mass="49431" checksum="9096EC930EECA9CA" modified="2019-04-10" version="1">MSTMSSPRSEMSVSTALPETDESRLMFYAEVLMANVPSLIADLSSAKYAFLSFSEKTRIEVKQKSALIQSIGRTFTSLQNSSKSLIAARQSLQECETKLVRAAPPTFVTSAEALHLSSARAHGDTTGAEQNGNASAEATAAEVRRLSAEAPDNVVILNEEDIRPVREAEEAYEKESAVYTEIAKACNKMEDAFDHAHDQCRVMTEHVQDLKWKFDEVYNGWKSAERERWVVRVMRDELEDRRAIMTEALLGIKAVEEECRAQEFRIIEGSIAHAQAEADVIKAELQAKRSRYELELATYQIAYKEQQAEVESLREHCKLLRSHQRDLEILAKKQQLEEMDRNCLRKLMMATLTLTPSKYGKAEDRTLTSEQQMEVRNDHLLVSVLAARISILEEQRKTVGGLLASARGMGKSNDVSATVEQIRTLLEPEVQLDEDALTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNS9</accession>
    <name>A0A3S7WNS9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040012600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNS9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0920"/>
    <dbReference type="OrthoDB" id="267013at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1091" mass="116962" checksum="D3A48E0928E214A9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP70</accession>
    <name>A0A3S7WP70_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger of a C2HC-type, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_050013600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP70"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0940"/>
    <dbReference type="OrthoDB" id="10255185at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF36">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="667" mass="68782" checksum="91DA9BC91EB1A67F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPB9</accession>
    <name>A0A3S7WPB9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-2 type transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette protein subfamily G, member 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_24505</name>
        <name evidence="11" type="ORF">LdCL_060005700</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPB9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0120"/>
    <dbReference type="OrthoDB" id="184675at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001495">
        <property type="entry name" value="ATP-binding cassette protein subfamily G, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF102">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="65"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP54894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="657" mass="73299" checksum="4DEF0E8FCDE0255D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ15</accession>
    <name>A0A3S7WQ15_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_070015500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_071070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070015500"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="257"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1550"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1728"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1558"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2320" mass="244703" checksum="07916B98B0F9F281" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQI7</accession>
    <name>A0A3S7WQI7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catalytic subunit of the vacuolar transporter chaperone 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_090007500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQI7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0320"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000003">
        <property type="entry name" value="Vacuolar transporter chaperone 4 catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="VTC" evidence="7">
        <location>
            <begin position="212"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="687"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="813" mass="93541" checksum="6C385AC5886B85BE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQK0</accession>
    <accession>E9B9R7</accession>
    <name>A0A3S7WQK0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_090310</name>
        <name evidence="2" type="ORF">LdCL_090008800</name>
        <name evidence="3" type="ORF">LDHU3_09.0480</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858710.1">
        <property type="nucleotide sequence ID" value="XM_003858662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQK0"/>
    <dbReference type="GeneID" id="13392073"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0480"/>
    <dbReference type="OMA" id="MQQTCHA"/>
    <dbReference type="OrthoDB" id="273727at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27288" checksum="FACA7486A755063E" modified="2019-05-08" version="1">MVRVGAKRERPCILVLHVALRAAQQPAREGPQRGREGGTSLSTSPRERFIWKTSATAEVYAKAVLRSIRAYWQLLGGVRYAGSDALTLISAVWQDIDDAALGATAAAQAGGIVEGDSPSASPLASTITTGVKRSKQQQQRRRQRMRATRRRSGVLRCAVHLSRSVYGDAGAAHVLRASCACVTEATVEVPVSQLVADDGSATVAADASNDDRRKRRRRRTEEDVEDVMPQTCHAAVHVTRVENVLPSRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR08</accession>
    <accession>E9BA71</accession>
    <name>A0A3S7WR08_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_23790</name>
        <name evidence="5" type="ORF">LDBPK_100230</name>
        <name evidence="4" type="ORF">LdCL_100007600</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858862.1">
        <property type="nucleotide sequence ID" value="XM_003858814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR08"/>
    <dbReference type="GeneID" id="13392202"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0360"/>
    <dbReference type="OMA" id="CGCCWPS"/>
    <dbReference type="OrthoDB" id="260546at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039964">
        <property type="entry name" value="KIAA0040-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40382">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40382:SF1">
        <property type="entry name" value="RIKEN CDNA 4930523C07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600650" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29542" checksum="13BD1937DF489372" modified="2019-05-08" version="1">MPTIRKLTAVAAVVAATVLLVATSATAQADQMCSDPANPLASIDYSDAAVQACVVARCTTTLNVTPTITADGFCDGVATSESSAPCNKLEMGYNAYYACLVHALQGTNTTGLAEFGAAAKEFFSTPGFPYRLSLLGCYACNHYRLTVFPSLDSKCSNWTCATVSSQSPSAPAYGQPDEGYNHRLCSTGCITGIIMIPFTVVTCAIFFACGCCWPSPSLKTTYEAMLQEERRKYRRHPAADDDDSHDLDNGCYSLAHEPAPVSDQKSHPEVAGQHSVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSG6</accession>
    <accession>E9BBA3</accession>
    <name>A0A3S7WSG6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fused homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC21_33125</name>
        <name evidence="16" type="ORF">LDBPK_130280</name>
        <name evidence="15" type="ORF">LdCL_130008700</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859240.1">
        <property type="nucleotide sequence ID" value="XM_003859192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSG6"/>
    <dbReference type="SMR" id="A0A3S7WSG6"/>
    <dbReference type="GeneID" id="13391064"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0460"/>
    <dbReference type="OMA" id="FARVMSC"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14002">
        <property type="entry name" value="STKc_STK36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000292">
        <property type="entry name" value="Serine/threonine-protein kinase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000223">
        <property type="entry name" value="Serine/threonine-protein kinase TIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120978" checksum="8771647B98A1E91C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT14</accession>
    <name>A0A3S7WT14_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_140014800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT14"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140014800"/>
    <dbReference type="OrthoDB" id="273475at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="227" mass="25814" checksum="00AF20DD6D1AD474" modified="2019-05-08" version="1">MLFGKGINALDANGFPHWLASADLAVMGEGHAMMQHRSGLSPEERLQITSTQKRSSQKIRRRMALAANPNSPYTAPEVLLDTILRYLPPTRHIGLRNLLQALPPAITDFLPTDPIRLLRNAPTKVQLFEFREQNNIRVMRPGLPLPDGRLRSTYSVDEWLHVLATELPPGRSRNSIDLFGRLRYGARETICLQHHHLINVVEQYPQYFVVVYAHAESAKKFARVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTV8</accession>
    <accession>E9BCQ7</accession>
    <name>A0A3S7WTV8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 16">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="7 16">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CGC21_25095</name>
        <name evidence="19" type="ORF">LDBPK_160540</name>
        <name evidence="18" type="ORF">LdCL_160010300</name>
    </gene>
    <organism evidence="18 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18 22" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 22">LdCL</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 16">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="7 16"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859741.1">
        <property type="nucleotide sequence ID" value="XM_003859693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTV8"/>
    <dbReference type="SMR" id="A0A3S7WTV8"/>
    <dbReference type="GeneID" id="13393108"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0640"/>
    <dbReference type="OMA" id="FDFAHFD"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002702">
        <property type="entry name" value="PRK02506.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 16" id="KW-0288">FMN</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="3"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU77631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP51187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="313" mass="33894" checksum="DCECC94473925808" modified="2019-05-08" version="1">MSLQVDLLNNTFANPFMNAAGVMCSTTEDLVAMTESASGSLVSKSCTPALREGNPTPRYRALPLGSINSMGLPNNGFDFYLAYAAEQHDYGRKPLFLSMSGLSVRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPQVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANVNAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALHEEGPAIFERLTSELLDVMAKKGYQTLDEFRGKVRTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTY9</accession>
    <name>A0A3S7WTY9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_160014700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTY9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1140"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000002">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="112" mass="13192" checksum="FA26B76A48A793AC" modified="2019-05-08" version="1">MDTKIKEPEGPCNLEYVRRYTHSLNYPLEKTSDMSEEMRADCKEIVVNALEKHEDNYEMAAKYVKEQMDKKFGPSWHCVIGEGFGFEITYEVKHLMYMFHRGFIAIVVFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUZ9</accession>
    <name>A0A3S7WUZ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="2 5">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_180015100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="2 5"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUZ9"/>
    <dbReference type="SMR" id="A0A3S7WUZ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1250"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="494" mass="54364" checksum="83B07F3B51D8A63A" modified="2019-05-08" version="1">MENDMKSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPVDSLDALDSLTIECDNAVLQSTVVLKLNGGLGTGMGLHDAKTLLEVKDGKTFLDFTALQVQYLRQHCSEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFDSEVELMQNQVPKILQDTLEPAAWAEDPGCEWAPPGHGDIYTALYGSGKLQELVKQGYRYMFVSNGDNLGATIDKRVLAYMEREKIDFLMEVCRRTESDKKGGHLARQTVYVEGKDGQPDAEKRGLLLRESAQCPKADMESFQDINKYSFFNTNNLWIRLPVLLEMMKEHGGTLPLPVIRNEKTVDPSNSASPKVYQLETAMGAAIAMFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDDRCHGHPPVVDLDSAHYKMMSGFEKLVQHGVPSLVECKSVTVKGLVQFGAGNVLAGTVKIENADSASAFVIPDGAKLNDTTASPPQSTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV78</accession>
    <accession>E9BDZ2</accession>
    <name>A0A3S7WV78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Got1/Sft2-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Got1/Sft2-like family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Got1/Sft2-like_family_putative/Pfam:PF04178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_38980</name>
        <name evidence="11" type="ORF">CGC21_5465</name>
        <name evidence="10" type="ORF">LDBPK_181610</name>
        <name evidence="8" type="ORF">LdCL_180021400</name>
        <name evidence="9" type="ORF">LDHU3_18.2050</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000025">
        <property type="protein sequence ID" value="TPP50603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860175.1">
        <property type="nucleotide sequence ID" value="XM_003860127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV78"/>
    <dbReference type="GeneID" id="13393463"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.2050"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5429378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP55195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="143" mass="15820" checksum="B921A0DF59C18F75" modified="2019-05-08" version="1">MDSLYNWNDSTKIGVAFTGLGMFFTFMGIVMLLDSILLTMGNFLFVAGVAMVMGPQRCKAFFIARQRASACFFVGILFVILRWCFIGLCIQGFGALNLFGNFFPVLVRVLESAPVIGPIILSAPVQKVLSLMHVNDVRNLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW39</accession>
    <name>A0A3S7WW39_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200019100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW39"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1810"/>
    <dbReference type="OrthoDB" id="267736at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="452" mass="48238" checksum="8B49F7361D2BC184" modified="2019-05-08" version="1">MRTTAGPAWTAGTGINRATGNGGAIEAAAGGDASYTAKAQHALSLFANLQANMRTSASPQSSEPAAHSTSETRASSATAHRTTAPSSHKHALDTHGRLTSSTPAATPNAGAARFSSLHSLQRVDSSDRADDAAALQTYTDAEIESLSPLQLRQQLRVAAAVTQRLRQRSRRLESEVEAWTHKYAELEAKAAGVRDADGEEGSAKERQAPSASRLNGDHSCRPTVVSSASKAAAPATPSAEGAAAHSRQLETEVRRLEAHKEELTRRLYAAEKTVRELREELRVAAAASPATTHSASSPPAAVNATTCENAPDKSRPETWKSGAAAAPPAQAPPSWRDAETKGERMDRCSNGTVEGDAAGENSVAHLRDTVRQLQRRLDLSEARAREAIQVHLDAVLLHRESTPSAVALVNAEVHKLFQLMQQQLLSNAVQHQAERARMNELLYHLQCQQHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW51</accession>
    <accession>E9BEW5</accession>
    <name>A0A3S7WW51_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_29040</name>
        <name evidence="3" type="ORF">LDBPK_201670</name>
        <name evidence="2" type="ORF">LdCL_200021500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860507.1">
        <property type="nucleotide sequence ID" value="XM_003860459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW51"/>
    <dbReference type="GeneID" id="13386293"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2040"/>
    <dbReference type="OMA" id="AQPYHPT"/>
    <dbReference type="OrthoDB" id="267792at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="274" mass="29440" checksum="DAFCB2C33BDB70FA" modified="2019-05-08" version="1">MSAWSSRNLAAMLKEQRASPATVVAPEDKKTNGDVPKRPAVSVEPKKPELPAPAAAGVLAAVSTPTPETVPTPGPASEPEVVYTSIGPVSMPQALAKLVTPSEFRFAGSVEAPKPVATLQPAVTHQPAEAAPKPVAIAPPIPVAAAPAPTVTSSSDLQQHQWNPPQPVYNPPVNDYMPRYQGALPYGGELGSVPRFYSTERQYNAQPYHPTYHTPYYRSGYSSSAIQYDGYSDMYHSHYPGQGAPHMGSRLQARPPYYPPRNPSLQQHPAAQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWF6</accession>
    <name>A0A3S7WWF6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PCI domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory non-ATP-ase subunit 5, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Proteasome_regulatory_non-ATP-ase_subunit_5_putat ive/GeneDB:LmjF.21.0760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_22505</name>
        <name evidence="4" type="ORF">LdCL_210013300</name>
        <name evidence="5" type="ORF">LDHU3_21.0940</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWF6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0940"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="244"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5429817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="474" mass="54244" checksum="DA5C821430FEF986" modified="2019-05-08" version="1">MADNEWKGASFKQDEDHSAETAKLLERVNATTIPVLLRSSNAKLGDIVAELLALEKVSRLGGDAASTKLLAVEVLRIYRTQNELDQMLETLDMLMKKRGQTKQAQSAMIAECAIVLTDDSLAKEKQEEVLERLAYVTENKIHVELEHARFTIELATLHEAAGRKRSACDMLRTLHIETITNMPRLEKLEALNQQIRLCLELEDYDHIPLVSRKINHRGLGRDEAQQQKLKYFELMRAYYAHKESFFNVGRCWYETYNTVKSTDDKLSALSNMVVHYLIAENATAKEIEDLAECTAFAPATKLHDRVAALSTISEKLRSDLEDIPQLYALLQRFNSIELIQERVSSEVEVLCQTHPELAPYPARQELLSNRCSEHDIMVIARFYTRIPLKRLAELVHLSPEHTEMFIMTMVTNKTLYAKMDRVDELVVFEARKNTTEVVASWNDSVERSVALLDKASHLITKERMLHNLASRKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWR4</accession>
    <name>A0A3S7WWR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxidase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peroxidase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Peroxidase_putative/Pfam:PF00141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_22015</name>
        <name evidence="5" type="ORF">LdCL_210024700</name>
        <name evidence="6" type="ORF">LDHU3_21.2270</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWR4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2270"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF15">
        <property type="entry name" value="PLANT HEME PEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="4">
        <location>
            <begin position="131"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="341" mass="38193" checksum="0F6F83E13C18E68F" modified="2019-05-08" version="1">MFKAPPEVGPGRKDTEEANPYKSWEHMNHTWLILMCLGCLCAGWLAGHFVEVDESKIKPKYAREDVVASACKQFEFRPDLAATSIRTAFVLAARRAGFPADTVDESCAVVRGLNDVAGIMNYLSNTYPASSTEDVASLAAIAGIKYLNGPYEAILDQWRWGRNDSDTAPKRNIPKDPDQKVFSIPTILHALGGLTEAECVALLACHSVGEFHEDVSGLEGATHTGKRYILNNRYYQFLLEHEKAFAPLTVARTQDNKEVAALPQTLKCVYVKEKANGKTKKRQCVVNAAELELLKNKTWRELVVRYAADEELWREQFQSAFTKMIESNFKRLRPYSDPNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX19</accession>
    <accession>E9BFR4</accession>
    <name>A0A3S7WX19_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_16580</name>
        <name evidence="11" type="ORF">CGC21_32710</name>
        <name evidence="10" type="ORF">LDBPK_220450</name>
        <name evidence="8" type="ORF">LdCL_220010800</name>
        <name evidence="9" type="ORF">LDHU3_22.0770</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860795.1">
        <property type="nucleotide sequence ID" value="XM_003860747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX19"/>
    <dbReference type="GeneID" id="13389360"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0770"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5430019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP54104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="183" mass="21079" checksum="F741761BBF28E6AC" modified="2019-05-08" version="1">MPPSNDLLGPSAGNPFLRKARVTYKRYLDASVPHRGLRWCFFAFLAILYVARVVTFGGFYVITYGLCIHLLYLLLLLITPLSDPDESEGTPLPTTHMDGDEYRPFMPKVQEFVVWKQMFTVLFVCLFLTMFSFLDIPVFWPILVLYFLMLFATQVGGRVRHMIKHGYVPWNTGKPKFVPKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY63</accession>
    <accession>E9BGP0</accession>
    <name>A0A3S7WY63_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_240280</name>
        <name evidence="3" type="ORF">LdCL_240007700</name>
        <name evidence="4" type="ORF">LDHU3_24.0320</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861118.1">
        <property type="nucleotide sequence ID" value="XM_003861070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY63"/>
    <dbReference type="SMR" id="A0A3S7WY63"/>
    <dbReference type="GeneID" id="13390568"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0320"/>
    <dbReference type="OMA" id="PVVDQLH"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000159">
        <property type="entry name" value="TFIIF-stimulated CTD phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="238" mass="27293" checksum="F2A802DC72B5165B" modified="2019-05-08" version="1">MVGLVKPLFPNTLLTEAQDERRLLTLVLDLDETLVSNRDSRQSAAVLRPYCLHVLNALRHMKELEIVLWTASTKETALPVVDQLHKTGIIFDDIIFRNSIWFTQPIHTKDLRLLGRDMNRVLIVDNSVGCCKLHPRNALLVEDFHGVRRREDAALVNVYYVVDALLRMMRERSIPVSEGLGRLMAEGQLCHPVSYDLPEFFKYIPLTEVPELKRPPVGCFVRANTAPPNTSIMQHWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZF1</accession>
    <accession>E9BHY4</accession>
    <name>A0A3S7WZF1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Parkin co-regulated family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Parkin co-regulated protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Parkin_co-regulated_protein_putative/Pfam:PF10274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_26190</name>
        <name evidence="5" type="ORF">CGC21_9125</name>
        <name evidence="4" type="ORF">LDBPK_252300</name>
        <name evidence="2" type="ORF">LdCL_250028800</name>
        <name evidence="3" type="ORF">LDHU3_25.2780</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861560.1">
        <property type="nucleotide sequence ID" value="XM_003861512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZF1"/>
    <dbReference type="SMR" id="A0A3S7WZF1"/>
    <dbReference type="GeneID" id="13388806"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2780"/>
    <dbReference type="OMA" id="INGPIHE"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="310" mass="34468" checksum="C1DCD36A987D1BBB" modified="2019-05-08" version="1">MSSYEIQPIVKGTKRDPSLRKYNKAAGAGPFGAAPASFRTKKPAPAQSAAAPPREAVDANTAVNAVRFPYTGTKRGYGGASSSLRKGRPRDAPDAAFSEKGCGKSAPPKAGAFKKRLIPPTEFRRAYDRGDLPIAICHGSRPTVDWKVEVEKLDYHHYLPIFFDGIRETEEPYMFLARQGCLDLLERGGPKILPTIPQLIIPIKTALNTRHPDIICATLRILQQLVVSDDLIGEALVPYYRQILPVLNLFKNVHKRRSRSDAMDYGQRNRDDVGDLVNETLQLLEQHGGEDAYINIKYMVPSYESCIYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZU2</accession>
    <accession>E9BIE2</accession>
    <name>A0A3S7WZU2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_31985</name>
        <name evidence="3" type="ORF">LDBPK_261300</name>
        <name evidence="2" type="ORF">LdCL_260018600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861717.1">
        <property type="nucleotide sequence ID" value="XM_003861669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZU2"/>
    <dbReference type="SMR" id="A0A3S7WZU2"/>
    <dbReference type="GeneID" id="13388963"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1600"/>
    <dbReference type="OMA" id="GRCGNFL"/>
    <dbReference type="OrthoDB" id="272326at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23652">
        <property type="entry name" value="mS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="278" mass="30097" checksum="FBD576B73EF4A07E" modified="2019-05-08" version="1">MKCSAALCRVASAVAAAVPKSCRNTPYTKKDEASATRPIKNITPKLADASNQSVRCGGGRCSNFLDVAPVPPPASVFRAAAANGSTFIDPSSSAVATSFNNNCHIKSFRQRVCTATDVSMRPLLLLLDDSQALNAMAANASIASAAAAAMKSGRSKYGDVLEQLSCRWAAKFYGKVTYGPRNYPYPSSRWLARRFQMKKHRILKRFRFRRYKLAAVANLPFAKMIRVGMLPELKSSKTKKGDTVDMGLSSQLVSAARSSAGATKTKGKRTRPKSKYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0P4</accession>
    <name>A0A3S7X0P4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_270019500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0P4"/>
    <dbReference type="SMR" id="A0A3S7X0P4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_072480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1990"/>
    <dbReference type="OrthoDB" id="246752at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34745" checksum="F577A0AC97413A89" modified="2019-05-08" version="1">MPSITTAKREYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAELIMGKKTLQAKIVEKRAQAKDASPEAKRFNDQCEEYNLLSGNTGLIFTNNAVQEITSVLDAHRVKAPARVGAISPCDVVVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTEKKVLSVGDKVDNSTATLLQKLNISPFYYQVNVLSVWDRGVLFTREDLMMTEDMVEKMLMEGLSNVAAMALGAGIPTSSTIGPMLVDAFKNLLAVSVATSYEFEEHNGKELREAAINGLLAGSGSAAAEPAAAAPAAPSAAAKEEPEESDEDDFGMGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0Z7</accession>
    <name>A0A3S7X0Z7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic cell cortex C-terminal pleckstrin homology, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_270029400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0Z7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3340"/>
    <dbReference type="OrthoDB" id="258005at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="451"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="571" mass="63240" checksum="FC81CD0F8999CEFB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Q8</accession>
    <accession>E9BL42</accession>
    <name>A0A3S7X2Q8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleosome assembly protein (NAP) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Nucleosome assembly protein (NAP), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nucleosome_assembly_protein_(NAP)_putative/Pfam:P F00956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_24880</name>
        <name evidence="6" type="ORF">CGC21_28715</name>
        <name evidence="4" type="ORF">LDBPK_292450</name>
        <name evidence="2" type="ORF">LdCL_290030500</name>
        <name evidence="3" type="ORF">LDHU3_29.3650</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862663.1">
        <property type="nucleotide sequence ID" value="XM_003862615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Q8"/>
    <dbReference type="SMR" id="A0A3S7X2Q8"/>
    <dbReference type="GeneID" id="13385366"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3650"/>
    <dbReference type="OMA" id="ISFRQNM"/>
    <dbReference type="OrthoDB" id="275780at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="184" mass="21038" checksum="4E8CF201C87E0BC3" modified="2019-05-08" version="1">MELSQCAAQAISKFTDDLVSIDRKCDEEATALRLEYRSKMEPLLMERRELLKGVTNFWSGVLSSPETPIATLLNGTIDPKIIRAVTDFQVVTRISENKLYRKIIFTFRQNMFVEEGEVSREVDTDMKTTSLHPVKWKSGTERARTDSFFAFFTENFSSDPEAVMEVTEALDTIYQDPFLAVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2U9</accession>
    <accession>E9BL85</accession>
    <name>A0A3S7X2U9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_24685</name>
        <name evidence="5" type="ORF">CGC21_28915</name>
        <name evidence="3" type="ORF">LDBPK_292880</name>
        <name evidence="1" type="ORF">LdCL_290034900</name>
        <name evidence="2" type="ORF">LDHU3_29.4200</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5432005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862706.1">
        <property type="nucleotide sequence ID" value="XM_003862658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2U9"/>
    <dbReference type="SMR" id="A0A3S7X2U9"/>
    <dbReference type="GeneID" id="13385409"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4200"/>
    <dbReference type="OMA" id="DHIVGMH"/>
    <dbReference type="OrthoDB" id="238486at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="204" mass="21919" checksum="D5D8C941EC244BC8" modified="2019-05-08" version="1">MKPHGLAVVPSIVQPSPFLTRAICALYWKDTFLGSCVAIAPSIVMTAGHHYNAVRDDVGDFSVLTRPGHWTAVEYASKDSTYDVVVFWLCEEVTTHTSLRGYLPAVGAQVATVWLSPKPPHDAIVSPGVVMESEAEKCVARGTVSMTGSSGAPVVDVFGEHIVGLHLTSNTRDGSRVSGFIPSRKLVSLFAEMWVEHARVLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X372</accession>
    <accession>E9BLK5</accession>
    <name>A0A3S7X372_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RF-1 domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">RF-1 domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RF-1_domain_containing_protein_putative/Pfam:PF00 472</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_7175</name>
        <name evidence="8" type="ORF">CGC21_35340</name>
        <name evidence="6" type="ORF">LDBPK_301120</name>
        <name evidence="4" type="ORF">LdCL_300016400</name>
        <name evidence="5" type="ORF">LDHU3_30.1450</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862825.1">
        <property type="nucleotide sequence ID" value="XM_003862777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X372"/>
    <dbReference type="GeneID" id="13385532"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1450"/>
    <dbReference type="OMA" id="SCHEHRS"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="202" mass="22170" checksum="19D777839ADBDC99" modified="2019-05-08" version="1">MSVRLLLGAGLAYARRLPLAPSPILSCCAPHLHTGVLWSLTEGARAAHTGSKEAGYYRLQNPKHINIDPCVYEIRTMRGSGPGGQGTNSSSNKVELRADMELLSEFFDDELLAALRRHEAGGALTSDGTTIVVSCHEHRSALQNKEGCLRKLQTLLHKASWVPPAEAGLVERPSFIVTEQKARRRKKSNMNRMTRSARSGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3D1</accession>
    <accession>E9BLR4</accession>
    <name>A0A3S7X3D1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Small GTP-binding protein Rab28, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_35650</name>
        <name evidence="4" type="ORF">LDBPK_301710</name>
        <name evidence="3" type="ORF">LdCL_300022400</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862883.1">
        <property type="nucleotide sequence ID" value="XM_003862835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3D1"/>
    <dbReference type="GeneID" id="13385591"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2390"/>
    <dbReference type="OMA" id="YKNVNLH"/>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04109">
        <property type="entry name" value="Rab28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001508">
        <property type="entry name" value="Small GTP-binding protein Rab28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="235" mass="25603" checksum="BFA6C94CB2119DA1" modified="2019-05-08" version="1">MESGSDSSEEGAMQFKVVVLGNGAVGKTSLIRHFCDSGFTKSYKQTIGVDFYSRKVQLPHSHPPVTLQLWDIGGQQIGGKMLANYIYGSHAVCLVYDITDLNSFKDLGDWKECVDKVFADAPAVDKPKMVLVGNKVDLPNRQVTDENQAAFSKNFSMPHCTVSAQSGERVNAMFTRIAATLAGVEMKQQDLDLADRVAANVVSRPEERQSAPRALVLQATSNSQGKRKNGDCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X498</accession>
    <accession>E9BMM0</accession>
    <name>A0A3S7X498_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_310960</name>
        <name evidence="3" type="ORF">LdCL_310016200</name>
        <name evidence="4" type="ORF">LDHU3_31.1640</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863187.1">
        <property type="nucleotide sequence ID" value="XM_003863139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X498"/>
    <dbReference type="SMR" id="A0A3S7X498"/>
    <dbReference type="GeneID" id="13385907"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1640"/>
    <dbReference type="OrthoDB" id="263936at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600684" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8183" checksum="E334059C8FBF6784" modified="2019-05-08" version="1">MSAMQLLIVALAACLSVAAAKSKEEFPLVWVCLGITVVGVIAALYVAYKRPDELHLPGSVVMTAVESDPGNGKSAAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5J8</accession>
    <name>A0A3S7X5J8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_20350</name>
        <name evidence="2" type="ORF">LdCL_320021600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5J8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2020"/>
    <dbReference type="OrthoDB" id="263978at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="516" mass="56706" checksum="2F7D4CAF4BBD9304" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6C3</accession>
    <name>A0A3S7X6C3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330005800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6C3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0100"/>
    <dbReference type="OrthoDB" id="259771at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="616" mass="66683" checksum="317FCEAFBF47F248" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6I6</accession>
    <name>A0A3S7X6I6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330016000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6I6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1520"/>
    <dbReference type="OrthoDB" id="16955at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1176" mass="122156" checksum="186D0885B95CF952" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7Y0</accession>
    <name>A0A3S7X7Y0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340024600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7Y0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2680"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21741" checksum="355A5AA79416AA7C" modified="2019-05-08" version="1">MKYGITLILYVVLQFVAFLLLLVGTPLDMFRKTKLTGYGTVKCITLWGVKENCASLDYDLTIYLFFSSCETRTALFRIAQSFAVISVLVYGAAFSLGFAMLFWCHFLRLVCLVLNVVGAITLCVVWAIVVTVFHRMDGPLCVSLRDFHFVFGTGFFFLVLAWCLDTLNIIILLLPCTVSATTDNEKTEPPTAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8H7</accession>
    <accession>E9BRD5</accession>
    <name>A0A3S7X8H7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_26995</name>
        <name evidence="8" type="ORF">LDBPK_343370</name>
        <name evidence="7" type="ORF">LdCL_340043100</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864496.1">
        <property type="nucleotide sequence ID" value="XM_003864448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8H7"/>
    <dbReference type="GeneID" id="13387375"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340043100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5560"/>
    <dbReference type="OMA" id="THVCITH"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="317"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ37814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP40245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="611" mass="68567" checksum="AE4AA79AD48E92CE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8X6</accession>
    <name>A0A3S7X8X6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350014900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8X6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1250"/>
    <dbReference type="OrthoDB" id="273699at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="836" mass="87948" checksum="47F64F3AA7BE906B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9I4</accession>
    <accession>E9BSG6</accession>
    <name>A0A3S7X9I4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein light chain, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Dynein_light_chain_putative/GeneDB:LmjF.35.2910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_352960</name>
        <name evidence="1" type="ORF">LdCL_350034500</name>
        <name evidence="2" type="ORF">LDHU3_35.3800</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864875.1">
        <property type="nucleotide sequence ID" value="XM_003864827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9I4"/>
    <dbReference type="SMR" id="A0A3S7X9I4"/>
    <dbReference type="GeneID" id="13387753"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3800"/>
    <dbReference type="OMA" id="YVIRPNF"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21459">
        <property type="entry name" value="DLC-like_TCTEX1D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF70">
        <property type="entry name" value="LIGHT CHAIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="123" mass="14439" checksum="233DBF562E67D57A" modified="2019-05-08" version="1">MQGEVDATTFSLRPDHHHKFRPNELKPIAKSVLESRLEDQEYNADEIQSISKEIADTVRDKIRSKDLERYKIIVHCMIGEQRGEGMRTGCKMFWDSDTDNYFEEVYVSKHLFATVTVFGVYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9I6</accession>
    <name>A0A3S7X9I6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand domain pair, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_350037600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9I6"/>
    <dbReference type="SMR" id="A0A3S7X9I6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4290"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000003">
        <property type="entry name" value="Phosphoprotein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000025">
        <property type="entry name" value="serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="664" mass="74010" checksum="71FDB343F9E3CD40" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9R4</accession>
    <name>A0A3S7X9R4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase A catalytic subunit isoform 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Protein kinase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_7475</name>
        <name evidence="11" type="ORF">LdCL_350045700</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9R4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350045700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5270"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF67">
        <property type="entry name" value="PROTEIN KINASE A CATALYTIC SUBUNIT ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="317"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP44662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="371" mass="42097" checksum="A369D0A2C7DC2D85" modified="2019-05-08" version="1">MSSAAKDSCPAESSGHLNNEKAQLSKIPSSHPDPSKVAVASKVKAAYSFERPDTSSWKLSDFELKNTLGTGSFGRVRIAHRKGTEEYYAIKCLRKREIIKMKQQQHVAQEKGILMELCHPFIVNMMCSFQDEKKVYFVLEFVMGGEMFTHLRTAGRFPNDVAKFYQAELVLAFEYLHSLDVIYRDLKPENLLLDNKGHVKVTDFGFAKKVPDRTFTLCGTPEYLAPEVIQSKGHGKAVDWWTMGVLLYEFIAGYPPFYDDTPFRIYEKILAGRLKFPNWFDGRARDLVKGLLQTDHTKRLGTLKGGPADVKSHPYFHGANWDKLYARYYPAPIPVRVKSPGDTSNFEKYPDSPVDRTPALTSAQQAEFNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9Y0</accession>
    <name>A0A3S7X9Y0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_350050000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9Y0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350050000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5930"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="125"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU83249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="317" mass="34744" checksum="1E0ED62A43CCFC58" modified="2019-05-08" version="1">MRSAIAAQPKGWDARYVNPNHPHDTSYYMKCIGGGILACGTTHTPLCPLDVVKCNMQVSPERFKSLGQGISLIMKEEGIGANGLMKGWLPTLCGYSAQGAFKFGLYEYFKDLYANMAGRENAKKYEGIIWLAGSASAEFFADMGLCPFEMTKVKVQTSPKGTFPTGMLAAMASMRADPSSGFPYKSLVPLWGRQIPYTMAKFFFFEKVVRMFYQYVFTKPKEQYNKATQLSITFASGYIAGVICAIVSHPADTLVSARGKASNAGKSYGQIAKEMGYINVCSKGLGTRILMIGTLTGLQWWIYDTYKTALGMGTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA86</accession>
    <accession>E9BT51</accession>
    <name>A0A3S7XA86_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_8100</name>
        <name evidence="8" type="ORF">LDBPK_355320</name>
        <name evidence="7" type="ORF">LdCL_350059000</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865109.1">
        <property type="nucleotide sequence ID" value="XM_003865061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA86"/>
    <dbReference type="SMR" id="A0A3S7XA86"/>
    <dbReference type="GeneID" id="13387987"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350059000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7080"/>
    <dbReference type="OMA" id="ETVRWIL"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="12"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="410" mass="45262" checksum="E819F475AA8A1960" modified="2019-05-08" version="1">MKFWDHVSGRGVVGAALNLSVTTIGAGVLVIPSTFQDGGICFVVGMLVLVGVMTVLSIDYLIRCIDCLHLKSYEDISRELLGRWFEEAVRWILIFYNIGMAAGYIVVIGEIFTPILPLLQPYLPFLTDSSHVMIMAWAFVMLPLSCIPKITKMNYICFVAITATFLISAIIVYRYLVPYDGKHNHAKVTYLSVSERALLAMPVMMFSFDCQSLVFQIYNNLRTVTRANMMRVASLSVSITGLVYLVVGLFGYLTHTPNITGNILANYDPFKDHLFAFGEAVYSFTVMAAYVLVLFPCRDAVFIFLYGHNTATHELAHAAITTRQNLVTSILLSALSIFLAMQVTGIVVVIALLGGLCSSTICFSYPAAFRIMLHIRGLDRCKPMELVTAISMLVFGVLGGSLGTFIAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA94</accession>
    <accession>E9BTA3</accession>
    <name>A0A3S7XA94_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_12550</name>
        <name evidence="3" type="ORF">LDBPK_360440</name>
        <name evidence="2" type="ORF">LdCL_360009300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865160.1">
        <property type="nucleotide sequence ID" value="XM_003865112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA94"/>
    <dbReference type="SMR" id="A0A3S7XA94"/>
    <dbReference type="GeneID" id="13388046"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0590"/>
    <dbReference type="OMA" id="CFMLEMM"/>
    <dbReference type="OrthoDB" id="275175at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="198" mass="22695" checksum="AFA34FB2E3BF577D" modified="2019-05-08" version="1">MYSDGERKTVSELQREAEATRKEIIEEAQRLERIKKATAKTQFSIDQLFRFFAREVETEKEKKMLIDLLVSNPPDLHIECVPVLPVVIAIANGRMTNARRIYTTDNAFLDDSAFILLVHTLRFLPQACKIDFLDISGTGVTERGMCFVLEMMIERNTPFTLVAKRLSIPSAEAEAVRARYTSLMSALRDKKCCRFIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAJ1</accession>
    <name>A0A3S7XAJ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360018900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAJ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1730"/>
    <dbReference type="OrthoDB" id="273032at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000262">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="175"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="452" mass="49572" checksum="E321DC955E268113" modified="2019-05-08" version="1">MHASALRYNFVSASFLIIFSHTWTTIYVTTYLSDDAPLQNTLFLVVGEVDNLSVTGDSPTTHPVSTLHIHTHRLLRTGTPFLFRHSVSMWKAVCRRKDAALAMLPVRCRPPMCCRALLRTRTSFVSGVVSTACPVLVMSARRWCATPPPHGTGSSGSQSIDEEAVVRAAKWSSSNFEERLGFRAGETITEERLKRHYRILAKHYHPDTSAGSGSSNGVGCEGETSAGRDGAFQSIKEAYDVVNAAVKQGGRRGGNASRGFSAEDFAGGFEFSDEARRRSQMRLLGDAVLLFVFMTVAFIGIVSSHNKSRMQSRYLWHLVGIFFIIQLFPRLFAAAILFAVHSMHLLEKATLQEQAAISLIVERTENACSVQLDGLRTEAQPNVVVQVTTTADADNEAAERVSSTLTFDKGVTAFTLPVPVNLSCVYHVKAVDEARKIVLVDRSLSARMPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBT5</accession>
    <accession>E9BUN7</accession>
    <name>A0A3S7XBT5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nin one binding (NOB1) Zn-ribbon like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Nin one binding (NOB1) Zn-ribbon like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_14925</name>
        <name evidence="14" type="ORF">LDBPK_365290</name>
        <name evidence="13" type="ORF">LdCL_360060100</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865643.1">
        <property type="nucleotide sequence ID" value="XM_003865595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBT5"/>
    <dbReference type="GeneID" id="13388529"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360060100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7070"/>
    <dbReference type="OMA" id="DYAMQNT"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000090">
        <property type="entry name" value="Nin one binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="288"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU83885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP48635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="440" mass="48071" checksum="D002896C3499DD50" modified="2019-05-08" version="1">MSWAALVKSIKPEEAANFTAKPRATVFAVDPSQNDAERQLRNPHHETAEVKLPSFSKGLLILDANAIIKGMDNFVSTADALVTTPQVIAEIKDRASRDLLERLPHQVTVLDPTPEAVAAVVACAELTGDFGAMSRTDIRLCALALDCCKVGGFLGEPIEPRPPQVNPGNADKVQVMTEDMNEDGSNDEREKSEPAHAQSAWLGAMPGSGGWSDEAKETDGEGGAGAAEEDDGEGEWITPENIQDVQSGTRGAGRAFEAGMACVTSDYAMQNTLMHLGVPIVGTNGIHIRELRLWMMRCTACFTLVVDTTRQFCPECGSGDTLRRVNYVVNDQGEKKLYINFRKRISTRGTIYNLPKPRGGTRGTNRNLVLREDQLAHVIRGTTSSKVKAHQVMQNDDCALATFGEAPKLKKKNLADPRAYSSYHRYNVNEKKKVRAAHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC31</accession>
    <accession>E9BV17</accession>
    <name>A0A3S7XC31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_366610</name>
        <name evidence="1" type="ORF">LdCL_360073800</name>
        <name evidence="2" type="ORF">LDHU3_36.8760</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865772.1">
        <property type="nucleotide sequence ID" value="XM_003865724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC31"/>
    <dbReference type="GeneID" id="13386626"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360073800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8760"/>
    <dbReference type="OMA" id="KCSRSIR"/>
    <dbReference type="OrthoDB" id="240179at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5435244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="194" mass="22029" checksum="B07155B6B2025B70" modified="2019-05-08" version="1">MCERIDSSRLERQSHPFHQLKCSRSIRNRAAVIYHLTRAKLHIKVPQDVLFSASLSYALNISRMSAKCPTLGQLRPVSNETDIVAVEMLIFEFVRPHVVLIEGCLRLELKRLVLHRPLPLKIRECVGRVAIALSDTLYACHYCLFPEAAARACLLNACERLSVDVDSATLPDEFRTPQVTEIRAFFSTPEAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJD8</accession>
    <name>A0A451EJD8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_010013800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJD8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010013800"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="739" mass="73423" checksum="1B1B3CE418303BB4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJP5</accession>
    <name>A0A451EJP5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S acidic ribosomal protein P2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_030009100</name>
        <name evidence="8" type="ORF">LdCL_030009200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJP5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0420"/>
    <dbReference type="OrthoDB" id="267775at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF6">
        <property type="entry name" value="ACIDIC RIBOSOMAL PROTEIN P2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11101" checksum="7520AB6E4B7D3217" modified="2019-05-08" version="1">MSAETLACTYAALMLSDAGLPTSAENIAAAVKAAGVEVRPTLPIIFARFLEKKSVETLMAAAAAQAPTAASAPSPAAGAASAAAAGGKVEDKKKDEPEEEGDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7F3</accession>
    <accession>A0A3S5H4Y0</accession>
    <name>E9B7F3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_020060</name>
        <name evidence="2" type="ORF">LdCL_020005800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857902.1">
        <property type="nucleotide sequence ID" value="XM_003857854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7F3"/>
    <dbReference type="GeneID" id="13390036"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0130"/>
    <dbReference type="OMA" id="TWRETCL"/>
    <dbReference type="OrthoDB" id="260172at2759"/>
    <dbReference type="PhylomeDB" id="E9B7F3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="314" mass="34033" checksum="3DA6590384449B24" modified="2011-04-05" version="1">MPPPYGQMTLRLGHSGACGSGMLRTTRNAVRRWLPLQPSWTRRPLATSSRISLDSSRCKATSGGGLWGTHPRHSPVRTSFVPSDISSAAAHKAKDAQLGESPQRSDTMRGPADAPPPTSFTLDPPFTRVTGEEELSPGPCAYVCRRCRALVFHSDRFADTSRVGWHASGWPTFLAPLTPSALRLSTVLQRSVIARLSDTPRDRPVSHISAGLTRPQRTLDIAVPPNSVAQRGLSVEGDLVRKRGNTISLQETRTWRETCLRDENHRADPVLVLAVCSACDTPLCHVTQSAALGTRYVSTAACIMAEAEGATPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BA94</accession>
    <accession>A0A3Q8I8R6</accession>
    <name>E9BA94_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_100460</name>
        <name evidence="4" type="ORF">LdCL_100009900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858885.1">
        <property type="nucleotide sequence ID" value="XM_003858837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BA94"/>
    <dbReference type="GeneID" id="13389280"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0640"/>
    <dbReference type="OMA" id="PCVCCLE"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="PhylomeDB" id="E9BA94"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730270" evidence="2">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17503" checksum="EDD5222C292507EE" modified="2011-04-05" version="1">MALAFSAGALVFAGASALYSWYAQEKAQRDQGYYCLPPRDGDIAVETGAAVAFKSSFLAASAAADGARETAAKDAPSHSPDALSEGCGVALSGEADGGHPCVCCLERHQSFMFVQCRHICLCEPCLIQLGRAYEDNKLRAHFDGPVRMPCPVCRTVGYIVKTYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAP9</accession>
    <accession>A0A3Q8I8Z7</accession>
    <name>E9BAP9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_110610</name>
        <name evidence="4" type="ORF">LdCL_110011500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859037.1">
        <property type="nucleotide sequence ID" value="XM_003858989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAP9"/>
    <dbReference type="GeneID" id="13389813"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0800"/>
    <dbReference type="OMA" id="AECCEMK"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="PhylomeDB" id="E9BAP9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="597" mass="63827" checksum="223DADA6D1D9EBE6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCW8</accession>
    <accession>A0A3Q8ICK9</accession>
    <name>E9BCW8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_161140</name>
        <name evidence="3" type="ORF">LdCL_160016500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859801.1">
        <property type="nucleotide sequence ID" value="XM_003859753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCW8"/>
    <dbReference type="GeneID" id="13393140"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1400"/>
    <dbReference type="OMA" id="AYLASWM"/>
    <dbReference type="OrthoDB" id="273901at2759"/>
    <dbReference type="PhylomeDB" id="E9BCW8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="559" mass="63557" checksum="55E8396EDD7B3562" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCY5</accession>
    <accession>A0A3S7WU36</accession>
    <name>E9BCY5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_161310</name>
        <name evidence="3" type="ORF">LdCL_160018300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859818.1">
        <property type="nucleotide sequence ID" value="XM_003859770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13393150"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1600"/>
    <dbReference type="OMA" id="LAHAWQC"/>
    <dbReference type="OrthoDB" id="247450at2759"/>
    <dbReference type="PhylomeDB" id="E9BCY5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1608"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1620"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1742" mass="187597" checksum="3EA8789B98697C61" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFK3</accession>
    <accession>A0A3S7WWY8</accession>
    <name>E9BFK3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component GAA1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_212180</name>
        <name evidence="2" type="ORF">LdCL_210027500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860734.1">
        <property type="nucleotide sequence ID" value="XM_003860686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFK3"/>
    <dbReference type="GeneID" id="13386479"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2590"/>
    <dbReference type="OMA" id="HHSTFVW"/>
    <dbReference type="OrthoDB" id="270864at2759"/>
    <dbReference type="PhylomeDB" id="E9BFK3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="464" mass="51266" checksum="D215E6252D6A68A5" modified="2011-04-05" version="1">MLRRAIFIGARHHGGKLAPFFLVLGIGLLCLLPVLRTRKIYIDENAIGQMFPSADAGSVTAYLDPTVRWPQQLVRGRRSPGSEIVAVYVNTDYPASVSLANALIEVIRRRKSLACDVQFYFVNSSEEWPVPQAYTRAALVLNLSTLYNRHICIDTLGANGIQPNQDYTNTAAQFAAANQFLPSYLCQRRHRSTDDAHAGFWHYWAYLEASVQLPTRPQPWHIIPSHSINTIAISSDPLYMASSMFPHSQLPDAFAQLVLQIIVSLNGLEEKFHHSTFVWLPVSLWHYVEYDHAQFCIILFVASIFSTTYSEYQLRGISITPLFVTLLLTPVAAAAVFQVAGWGAVAAASAAFSLLFRLLMGHVNSGMLLSFNAIALCLLIILQPACGLVAGAAAAIQVSFIHNALQNRPAMAVGAAVSSALAYYFIYHLRLPLFGVDGISELFVSFVIYPNAVWIGSRLLCLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFT0</accession>
    <accession>A0A3S5H7A8</accession>
    <name>E9BFT0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor SUI1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_220610</name>
        <name evidence="3" type="ORF">LdCL_220013400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860811.1">
        <property type="nucleotide sequence ID" value="XM_003860763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFT0"/>
    <dbReference type="GeneID" id="13389376"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1040"/>
    <dbReference type="OMA" id="MFKKKCT"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="PhylomeDB" id="E9BFT0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000014">
        <property type="entry name" value="Translation initiation factor SUI1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000012">
        <property type="entry name" value="Translation initiation factor SUI1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="571"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="664" mass="73700" checksum="FF5E8FB66002DA31" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHE6</accession>
    <accession>A0A3Q8ICD2</accession>
    <name>E9BHE6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation initiation factor SUI1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_250420</name>
        <name evidence="4" type="ORF">LdCL_250009300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861372.1">
        <property type="nucleotide sequence ID" value="XM_003861324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHE6"/>
    <dbReference type="GeneID" id="13388619"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0490"/>
    <dbReference type="OMA" id="WRKRFSC"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="PhylomeDB" id="E9BHE6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000024">
        <property type="entry name" value="Translation_initiation_factor_SUI1_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="295" mass="32997" checksum="F27D2D721A6438F9" modified="2011-04-05" version="1">MGRSKRSKATAHAQPCSDGEREEEHDSAPATVLPEQAEGCGDENGASAAADGAQATPDQHSGRCSERGRDSDDDAPKTKKKEYRGNRLKKLEVQRKKGKGKGANEDDKAEEAAREGDADEEPLIVTRQRAVEVLYCPICTFPAEMCEFSGIVEKCRPWLLEYAADLADAEERGRKRRILTEKDRLEAMLEGRGVKKALERIVVLEVEKRTGRRMITSVFGMDLFGFNLKDVSRDWRKRFSCGAGVRAAEEGKHQDCIDIQGNVVDQLADMLITKYRIPKESVYLMEGKKKVPYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHT5</accession>
    <accession>A0A3S7WZA0</accession>
    <name>E9BHT5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PORR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_251810</name>
        <name evidence="2" type="ORF">LdCL_250023800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861511.1">
        <property type="nucleotide sequence ID" value="XM_003861463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHT5"/>
    <dbReference type="GeneID" id="13388757"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2250"/>
    <dbReference type="OMA" id="VKMRCMG"/>
    <dbReference type="OrthoDB" id="263068at2759"/>
    <dbReference type="PhylomeDB" id="E9BHT5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34856" checksum="5FED2B2B37470C9D" modified="2011-04-05" version="1">MKPMRLCCPLWRAAPAHPAAQHTAQRMRIFTATAIFTFLPSSSAAATTGSLYPSPLLHQRRAVGQSSTLPGASLSLSEKSSTAGSSSPVARESSVGNRDAAKEGPPSLEPVIVELGTLVTRTMPVGELFRALSPASRKILVAHRLPLEELLLHFPNHFLVCRLGAKRTSQSATLHVAPPSCAKNNMHVMRLPPGTKPLPALEQWLGPQKAMEVAMPNSSIVGGSPCIGTGSGFVGNTTTLKERLEEVLTYIPNEWVAFSSLNISRDVKMRCMGYPLVRPCAFLLKYPQFFDVRVQDRNGNSFLVRRALSLQQQLNRTRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BP44</accession>
    <accession>A0A3S7X5Y8</accession>
    <name>E9BP44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase III epsilon subunit-like exonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Exonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_322930</name>
        <name evidence="5" type="ORF">LdCL_320035300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863706.1">
        <property type="nucleotide sequence ID" value="XM_003863658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BP44"/>
    <dbReference type="GeneID" id="13391231"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320035300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3710"/>
    <dbReference type="OMA" id="AVHGITW"/>
    <dbReference type="OrthoDB" id="242056at2759"/>
    <dbReference type="PhylomeDB" id="E9BP44"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000289">
        <property type="entry name" value="Exonuclease-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231">
        <property type="entry name" value="DNA POLYMERASE III SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30231:SF4">
        <property type="entry name" value="PROTEIN NEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20749" checksum="71C73BA5BE78462F" modified="2011-04-05" version="1">MCGVIEGLWIRGGRVFHRYVRPSDPRRISAAAAAVHGITWETVQHCSPWTVAASELVAYMTLVGADAPVSASAQLEAAQLGGDRAVRLPPLVAHNASFDARFLEHHLRRCGYQIFWHPQYPLTCTRQWAQVAYPHLANNLDALCAFLSIDGAADRVANGHGALTDATLTALLFLQMCRRWTERFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPC0</accession>
    <accession>A0A3Q8IH56</accession>
    <name>E9BPC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_323700</name>
        <name evidence="2" type="ORF">LdCL_320043000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863781.1">
        <property type="nucleotide sequence ID" value="XM_003863733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPC0"/>
    <dbReference type="GeneID" id="13391544"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320043000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4700"/>
    <dbReference type="OMA" id="MTLDMDP"/>
    <dbReference type="OrthoDB" id="259656at2759"/>
    <dbReference type="PhylomeDB" id="E9BPC0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="300" mass="33617" checksum="B0EAD8009D91489C" modified="2011-04-05" version="1">MGKTHDHEPPATMKPLEELTDADTREMRDLGIGEGMFNRILTSCMKFALSGGWSVRKRDAKYDIVWETKPSHNSNKQAMRFTAKVPNCNTGSLEAILADDEYLEDDPNVSYMYKYDGLLQQNHAEKRIAGNVTVQSTHYGAPVMFVAPRHIISYVTLGALLTPAQQKELGIRPTGLRDQPADAERTDNLMAFTQCCIDYTGDAVELRKGSERGHVYSYSLLGQEEPDGSMTVTMTLDMDPAGKLPAKVVDMSSDEQHKKMQRIVELLKAKGPQPHLCSVYQNTRDFPFRNPSKGEVEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUV1</accession>
    <accession>A0A3S7XBV5</accession>
    <name>E9BUV1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_365940</name>
        <name evidence="1" type="ORF">LdCL_360066800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865706.1">
        <property type="nucleotide sequence ID" value="XM_003865658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUV1"/>
    <dbReference type="GeneID" id="13388593"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360066800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7850"/>
    <dbReference type="OMA" id="YPHARYK"/>
    <dbReference type="OrthoDB" id="275703at2759"/>
    <dbReference type="PhylomeDB" id="E9BUV1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="322" mass="37181" checksum="731F018E0402CED7" modified="2011-04-05" version="1">MQRSSLGACTVAAAQLHACASLHSSTLMSCGCSPLTVQRRGLRNLHQYPHARYKSLVKDCHRFSRNWWLTAGNNYELVSEVGHEREATENFAVLRDDSDKDAYVLSTNRLEDLPPAERLNMLVALMTERWKVKDNNRGYDKAKMLLKALECFSEMRLSGQIKVFDELPEPDQDTFLQYVEGCAQFAQGCSHSHPDAVAMVLRAAEICDEMRCVDKREEMTHVAEVMAQRLDRACASARPLETKAQLTPPSITEIHSGLRVKQMRELRDRFKDKPWVLEPKKRIEYFYGPRSRKIFHTPMRRDDIHRNLLAIPHRPETRSWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUZ6</accession>
    <accession>A0A3Q8IK47</accession>
    <name>E9BUZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_366390</name>
        <name evidence="2" type="ORF">LdCL_360071400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865751.1">
        <property type="nucleotide sequence ID" value="XM_003865703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUZ6"/>
    <dbReference type="SMR" id="E9BUZ6"/>
    <dbReference type="GeneID" id="13386605"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360071400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8480"/>
    <dbReference type="OMA" id="RAHETPI"/>
    <dbReference type="OrthoDB" id="267050at2759"/>
    <dbReference type="PhylomeDB" id="E9BUZ6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34868" checksum="1C0C64A076181D7F" modified="2011-04-05" version="1">MSTRRAYETPIAVSSAASAVSSVTSSKRPTPQLSSFAIRLRGSKGSSCPAQKTAESDSCVPSMRLHDSDAVGDTQQATGNIYAASSLRSASTAMTQLKTSLSQMQRLVRLQQGQLSALLRAHGDLQRQVTVQHGAYNEMVQRSMSQRAEMEAALQKHTAQWRRQQAAMQESVAALWDIVSDIHQHLHNNGRLPAKILAASRQTEESAYYSDIASFVQADVAAPSLVSASLLARKDDPLLPAQASVSAFANGFTRPSAPSSACALGFASAAAGPSATAARGPSYTMDMQQQQQQQQRESMEDRVVAMLRKKPTVVVRHLAWRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I803</accession>
    <name>A0A3Q8I803_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin, putative</fullName>
            <ecNumber evidence="8">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_110014100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="8"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1070"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="894"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1147"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1417" mass="148509" checksum="CDC890B5FE4B7C8F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAK8</accession>
    <name>A0A3Q8IAK8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_160015500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAK8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1250"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="4">
        <location>
            <begin position="560"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="974" mass="106254" checksum="234F96F2812E2220" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAQ1</accession>
    <accession>E9BFU4</accession>
    <name>A0A3Q8IAQ1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_16355</name>
        <name evidence="16" type="ORF">CGC21_2270</name>
        <name evidence="15" type="ORF">LDBPK_220770</name>
        <name evidence="13" type="ORF">LdCL_220015100</name>
        <name evidence="14" type="ORF">LDHU3_22.1250</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860825.1">
        <property type="nucleotide sequence ID" value="XM_003860777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAQ1"/>
    <dbReference type="SMR" id="A0A3Q8IAQ1"/>
    <dbReference type="GeneID" id="13389390"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1250"/>
    <dbReference type="OMA" id="NICNAPA"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5430059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP54059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="358" mass="39883" checksum="CA441EFF01CEBD83" modified="2019-04-10" version="1">MQSSASLPEQQPVNGSSDPQNHHYVNPLVSSFPTVVGPKLPCKYRVRRAIGRGAFSTVWLLINNRTGETVVGKLSDASHSSSACKAFAEAEVENMRCCSHPNIISLIETFEAGEKSLYILEYANAGDLQAQVDTRAQPPPGANDGTPIPYREDEALVIFAQLSLAIRYLHDRRIMHRDLKTSNVLLTRSGLIKLGDFGFSRQYQESVSGEVGKTFCGTPYYLAPEMWQRQSYSYKADIWSLGVIMYELLALKKPFQATNLSELMETVTRQGSFDPLPADRYSSDMISLVNQMLRVDPSERPSINDILALPLFQQRGLTILKINVRRIKNLDAEVRTRLVEDVEAVLGDNNLSSEASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB98</accession>
    <name>A0A3Q8IB98_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_190010500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0610"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF8">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CH-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1384" mass="145362" checksum="4D5AE4C347324779" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBY9</accession>
    <name>A0A3Q8IBY9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_240020700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBY9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1890"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001582">
        <property type="entry name" value="WD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="434" mass="47350" checksum="979D3D444CE3D308" modified="2019-04-10" version="1">MKATPILSTDTAEQARLKLRHQHPEYIEEEQQQRDSKKTRATSEEAENEDDDIDDDDEDGLNANVDETLRVFAGGGPGALLEEVESDDEEELEDTTLKPTDLVFTVACADAQAPRLEMYVYDEPEDNMYVHHDMEIAAFPLCSSWLTDGTMSMLAVGTMLPFIEIWALDVMDSVEPAIILGGCERRSHNYSKRMLKRNLKADSHTEAVLSVKWNTVAQNIFASGSADRTIKLWDLNQGGVCLGTYSELEKVQSLDWHATEANLLLSGGFDASMVLRDCRQPDQTAQRYGLPGIIEHVEFVPSAGAAAASAPVVMASTSGGHWAAFDTRMASSNAGHSPVTSLWQLQPHQADMTFSCSRQVPGLFATGGKEGEIALWDGRDSSAAPKMVVSRSYKTGSVLSLSFHPNSPHILGAGGASGAPLVYTITSDIYDVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC20</accession>
    <name>A0A3Q8IC20_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 2, C-terminal putative domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_210017000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC20"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1420"/>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF2">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="435" mass="46935" checksum="2145979C9650DB35" modified="2019-04-10" version="1">MSHKRDRLTSETKLGGTPTYFPPLSDADKAQIRRWTSCGVCGHAMSLLTQAYSPLPTASASRPHHRMMYVFACNSGYCSRQPTSSMVAFSVQVDQEDEQALAENSEEEEKDEVIETGPLLPSELPEAVLPPCYVYIDAEPSKEVVVPTDIERELIKMAEENARSTVTDEELQQLEQTVDLKNKKTDYYYEKFRSRVARAPNQVLRYYERTVAAAAATSASLRAKDVKPIFMNPDKVKAMVTIPACACCGSAQTAELQVMPTSLYYLHVSEYTALARADAAAMAAPAGAPAAASTQGNAVDKQPPVASHSASTTACKASASSGAATGTEKAIPANVDDGCDFGTITVYVCAKDCAARQHGVVLRRETLCVEEAPTMRDEERAGKADAAKAVTDGVTHKLTLRELLHGNGEGDEDMEDDEGHIDDEGHIDDEAVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICC0</accession>
    <name>A0A3Q8ICC0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_110008700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICC0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0480"/>
    <dbReference type="OrthoDB" id="272066at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="3">
        <location>
            <begin position="761"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123131" checksum="AE5DA67F56F2ECE9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICG0</accession>
    <accession>E9BCM9</accession>
    <name>A0A3Q8ICG0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA carboxymethyluridine synthase</fullName>
            <ecNumber evidence="15">2.3.1.311</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CGC21_25230</name>
        <name evidence="20" type="ORF">LDBPK_160250</name>
        <name evidence="19" type="ORF">LdCL_160007400</name>
    </gene>
    <organism evidence="19 23">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19 23" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 23">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="15"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859713.1">
        <property type="nucleotide sequence ID" value="XM_003859665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICG0"/>
    <dbReference type="GeneID" id="13393078"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0300"/>
    <dbReference type="OMA" id="YLQADQW"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000011">
        <property type="entry name" value="Elongator complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF2">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="497"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU77602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBZ33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP51214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="759" mass="85082" checksum="694F49121CEF57E4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID73</accession>
    <accession>E9BIT5</accession>
    <name>A0A3Q8ID73_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_32640</name>
        <name evidence="9" type="ORF">LDBPK_262740</name>
        <name evidence="8" type="ORF">LdCL_260033500</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861858.1">
        <property type="nucleotide sequence ID" value="XM_003861810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID73"/>
    <dbReference type="SMR" id="A0A3Q8ID73"/>
    <dbReference type="GeneID" id="13389106"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3600"/>
    <dbReference type="OMA" id="SVTELMF"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000057">
        <property type="entry name" value="Glutamate 5-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="263" mass="29033" checksum="B8B0375C65F3B1F8" modified="2019-04-10" version="1">MADILKSVKRIVVKVGSSILVDNQEIAAHRIEALCQFIADLQTKYEVILVTSGAVAAGYTKKEMDKSYVPNKQALASMGQPLLMHMYYTELQKHGILCAQMLLAAYDLDSRKRTINAHNTIEVLISHKVIPIINENDATALDELVFGDNDRLSALVAHHFKADLLVILSDIDGYYTENPRTSTNATIRSVVHELSPDDLVAEATPNNRFATGGIVTKLQAAQFLLERGGKMYLSSGFHLEKARQFLLGGSHEIGTLFYSRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDC4</accession>
    <name>A0A3Q8IDC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Right handed beta helix region/Periplasmic copper-binding protein (NosD), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_270013300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1070"/>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000089">
        <property type="entry name" value="Right_handed_beta_helix_region /Periplasmic_copper-binding_protein_(NosD)_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000131">
        <property type="entry name" value="Right_handed_beta_helix_region /Periplasmic_copper-binding_protein_(NosD)_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000182">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000188">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF32">
        <property type="entry name" value="RIGHT HANDED BETA HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="516"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="660"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="792"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2407"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2864"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3153"/>
            <end position="3178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3211"/>
            <end position="3291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2879"/>
            <end position="2897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3168"/>
            <end position="3178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3230"/>
            <end position="3243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3274"/>
            <end position="3291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3291" mass="347054" checksum="6FEFA2D8C20E54D3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDG0</accession>
    <accession>E9BHM1</accession>
    <name>A0A3Q8IDG0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase VII, putative</fullName>
            <ecNumber evidence="2">1.9.3.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cytochrome_c_oxidase_VII_putative/GeneDB:LmjF.25. 1130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_26685</name>
        <name evidence="5" type="ORF">CGC21_8635</name>
        <name evidence="4" type="ORF">LDBPK_251170</name>
        <name evidence="2" type="ORF">LdCL_250017100</name>
        <name evidence="3" type="ORF">LDHU3_25.1490</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861447.1">
        <property type="nucleotide sequence ID" value="XM_003861399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDG0"/>
    <dbReference type="GeneID" id="13388693"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1490"/>
    <dbReference type="OMA" id="AYSFRWI"/>
    <dbReference type="OrthoDB" id="268402at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="165" mass="19056" checksum="5A05ECA82D409CFF" modified="2019-04-10" version="1">MPRPFGVWAPATTLAEYRARIPNPFAYSFKWVYAMKKEVFYPPEALAHFKDPQQFKDAVDTVIAMRVSDKIFGEGQKLPRHPVILMVMVLATHGFIIFSGLKYYYGTYMPANNPTWRKTVNKEWEEAINNSPWDHMSHVWQYSDEYAAALGDTAAPGQRKFYIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDK4</accession>
    <name>A0A3Q8IDK4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 33, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250028600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDK4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2760"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="597" mass="67520" checksum="AB2825176008DD0F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDT1</accession>
    <accession>E9BQ97</accession>
    <name>A0A3Q8IDT1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_10640</name>
        <name evidence="17" type="ORF">CGC21_37810</name>
        <name evidence="16" type="ORF">LDBPK_331660</name>
        <name evidence="14" type="ORF">LdCL_330023200</name>
        <name evidence="15" type="ORF">LDHU3_33.2500</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863992.1">
        <property type="nucleotide sequence ID" value="XM_003863944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDT1"/>
    <dbReference type="SMR" id="A0A3Q8IDT1"/>
    <dbReference type="GeneID" id="13392387"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2500"/>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU82144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5433368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ37309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP53711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP55534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="263" mass="28275" checksum="037D21CB80866E14" modified="2019-04-10" version="1">MTEFNRYNHEDKSTWLNAVEKPQAPLEAIIDPSILAADFCKLGDEVASVVSPAGGAAEWIHVDVMDGHMVPNISIGPGVVSSLRARFPNVFLDVHCMVSDPKQWVPSIAKAGGSGYTFHIEATNDSKDVAEYIRAHGMQVGVAVKPATNLTQELKDLIEGHYVDQVLVMTVEPGFGGQSFMHERLSFISELRRNYPHLNIGVDGGIGPSTAEQAADAGANILIAGTSVFRAGDRKAAIEELRASAKSGICKNSRIQRALPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE53</accession>
    <name>A0A3Q8IE53_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_270005400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE53"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0070"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="163"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="447"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="787" mass="88273" checksum="72BDC75F8B762757" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE99</accession>
    <accession>E9BIZ2</accession>
    <name>A0A3Q8IE99_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH-quinone oxidoreductase, B subunit family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase 20 kDa subunit, mitochondrial</fullName>
            <ecNumber evidence="12">1.6.99.3</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="13">NADH-ubiquinone_oxidoreductase_20_kDa_subunit_mit ochondrial_precursor/GeneDB:LmjF.27.0740</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_33005</name>
        <name evidence="16" type="ORF">CGC21_31095</name>
        <name evidence="14" type="ORF">LDBPK_270590</name>
        <name evidence="12" type="ORF">LdCL_270012400</name>
        <name evidence="13" type="ORF">LDHU3_27.0960</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="12"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861915.1">
        <property type="nucleotide sequence ID" value="XM_003861867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE99"/>
    <dbReference type="SMR" id="A0A3Q8IE99"/>
    <dbReference type="GeneID" id="13389175"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0960"/>
    <dbReference type="OMA" id="GCGGIEM"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000006">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 20 kDa subunit,mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="11">
        <location>
            <begin position="77"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5431184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP46117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP47577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="201" mass="22854" checksum="5CF165EFE82AA7DA" modified="2019-04-10" version="1">MLRFTRASFTGRAMISRGSPEWSHRLDLKKGKKTTLAHKLGTSKPNNALQYAQMTLHDLTEWVVAYSPWPLTFGLACCAVEMMHSYSSRYDLDRFGIVPRPSPRQAEIIIVSGTVTNKMAPLLRNIYVQMVNPKWVISMGSCANGGGYYHFSYAVLRGCERAIPVDFWIPGCPPSAESLVFCLHNLQKKIRWHEIQKYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEB2</accession>
    <accession>E9BJ71</accession>
    <name>A0A3Q8IEB2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_30720</name>
        <name evidence="3" type="ORF">LDBPK_271390</name>
        <name evidence="2" type="ORF">LdCL_270020700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861992.1">
        <property type="nucleotide sequence ID" value="XM_003861944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEB2"/>
    <dbReference type="GeneID" id="13386726"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2130"/>
    <dbReference type="OMA" id="YAGWHVW"/>
    <dbReference type="OrthoDB" id="313433at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40682:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_48, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40682">
        <property type="entry name" value="F5/8 TYPE C DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="697" mass="74310" checksum="32427FF6568D541F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEP9</accession>
    <name>A0A3Q8IEP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Divalent cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280025700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEP9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2730"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="678" mass="72351" checksum="DC75AC17AB4C01EC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFA9</accession>
    <name>A0A3Q8IFA9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR/MLP1/MLP2-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310007500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFA9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0300"/>
    <dbReference type="OrthoDB" id="10259720at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033290">
        <property type="entry name" value="CCDC39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24161">
        <property type="entry name" value="CCDC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="456"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="859" mass="99946" checksum="5B724ED13BC6D61C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFI8</accession>
    <name>A0A3Q8IFI8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Surface protein amastin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_35245</name>
        <name evidence="2" type="ORF">LdCL_300014400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFI8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1170"/>
    <dbReference type="OrthoDB" id="244479at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="198" mass="21243" checksum="381A187E51B047A1" modified="2019-04-10" version="1">MGFEALRGRMDVALSMLCSCIVFMFLVTSAPISQFRGRGINASATGGASKLSCVTVWGLKNDCNANNYDYRPTSIGCARSKQLFQVSEAFYILAVIVSFLSCLMSGLYFMGIKAKVLLVLLAVLEVVFALIPWVCMTAVWYGNYCGGSTVKINTSSGKADGVPHGSVLRESFKVSAGYGLTVAAWCTQVIGLVLLIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFJ8</accession>
    <accession>E9BSY8</accession>
    <name>A0A3Q8IFJ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Protein_kinase_putative/GeneDB:LmjF.35.4620</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_14440</name>
        <name evidence="11" type="ORF">CGC21_7760</name>
        <name evidence="10" type="ORF">LDBPK_354690</name>
        <name evidence="8" type="ORF">LdCL_350052000</name>
        <name evidence="9" type="ORF">LDHU3_35.6170</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865046.1">
        <property type="nucleotide sequence ID" value="XM_003864998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFJ8"/>
    <dbReference type="SMR" id="A0A3Q8IFJ8"/>
    <dbReference type="GeneID" id="13387924"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350052000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6170"/>
    <dbReference type="OMA" id="RCCAPEI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP44719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP47874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="288" mass="30720" checksum="9F3894041276E36C" modified="2019-04-10" version="1">MLATPSLPPLSSSGNQQGAWARRILKSDVYPSSLEAIRARVEALRGRWRDGGAAHIVPITRVVCTPLYLRLEVDESLALELLGPPWEYERHSAPMGERDAALCVLSVAQLLSRLHAVGVVHGHLQGGVVWHHTGDALRIVVTECELPITALVPYGGVGSEARQCAAPEILRGDPYAGAADVWGLGVLLVQLLLGSSKPVCTADLENSDLLSPFISSLGPSAASFVLPCVKSDPHARPLLLQVLQHPFLASALPVHGNEVGDEQRNDCSSEDSNTSEGEELEDSDTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH70</accession>
    <accession>E9BIL7</accession>
    <name>A0A3Q8IH70_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein tyrosine kinase/Protein kinase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_32325</name>
        <name evidence="4" type="ORF">LDBPK_262060</name>
        <name evidence="3" type="ORF">LdCL_260026200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861791.1">
        <property type="nucleotide sequence ID" value="XM_003861743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH70"/>
    <dbReference type="GeneID" id="13389038"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2690"/>
    <dbReference type="OMA" id="YFPAYIS"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="350"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1105" mass="118411" checksum="ADA199931202F5DA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II29</accession>
    <accession>E9BJL4</accession>
    <name>A0A3Q8II29_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="9">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="9">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="9">PHB:PPT</shortName>
            <shortName evidence="9">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_13410</name>
        <name evidence="12" type="ORF">LDBPK_281430</name>
        <name evidence="10" type="ORF">LdCL_280018900</name>
        <name evidence="11" type="ORF">LDHU3_28.1790</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="9"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862242.1">
        <property type="nucleotide sequence ID" value="XM_003862194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II29"/>
    <dbReference type="GeneID" id="13386978"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1790"/>
    <dbReference type="OMA" id="YDSWSCA"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5431524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP40497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="489" mass="54665" checksum="3A61F970BF41732F" modified="2019-04-10" version="1">MFRRTLFWPKVTRSWTTSSISAATAHFPDAVHADPASSRTGSTSAKESRSWKLGDDTVKAEALPKHLQLAVRKLQVYGDLVRFSRPVGWQLLLIPCYWGSSLAVTRALVWEGADPVVLCAPFIPLHLCVQFLLGAYLMRSVGCIVNDMWDRKFDRMVERTAQRPLACGAISMTEASAILLLHLSVAGVIALNLSPAALQACVAITPIWLIYPFMKRITYAPQLFLGLCFNWGIFVGYAAVLGRVDMAVCLPIYGGAVIWTILYDTIYAYQDRRDDLKCGVKSTAIWIGDRKYILNAMVAPIGASLLISGFLASQSLPYYIGIVLCMYHLHSIVDDVNIYDSWSCAQGFKRNVRVGMYVFMAMCLGNLCWAFASEHEAELDRNTDSAPKSSALSRFLFLDQETHGSMYTKGSFNWADRFMHPAFVQAESAKLAGATEAPPIPAWMRREYFWQNVSAILLFCGVAEDTVAAWSTFSYEWMDHYNMFSKVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ05</accession>
    <accession>E9BNF1</accession>
    <name>A0A3Q8IJ05_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">9,11-endoperoxide prostaglandin H2 reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prostaglandin F2-alpha synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CGC20_33550</name>
        <name evidence="26" type="ORF">CGC21_19795</name>
        <name evidence="25" type="ORF">LDBPK_320470</name>
        <name evidence="20" type="ORF">LdCL_320009600</name>
        <name evidence="21" type="ORF">LdCL_320009800</name>
        <name evidence="22" type="ORF">LdCL_320010000</name>
        <name evidence="23" type="ORF">LdCL_320010200</name>
        <name evidence="24" type="ORF">LDHU3_32.0580</name>
    </gene>
    <organism evidence="21 29">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="25 28" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 28">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21 29" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 29">LdCL</strain>
        </source>
    </reference>
    <reference evidence="30" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="31" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="26" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">FDAARGOS_360</strain>
            <strain evidence="26">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="24" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>prostaglandin F2alpha + NADP(+) = prostaglandin H2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863465.1">
        <property type="nucleotide sequence ID" value="XM_003863417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ05"/>
    <dbReference type="SMR" id="A0A3Q8IJ05"/>
    <dbReference type="GeneID" id="13390277"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0580"/>
    <dbReference type="OMA" id="VHWPSEG"/>
    <dbReference type="OrthoDB" id="276363at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="19">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="18">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU81589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AYU81591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AYU81593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAC5432803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CBZ36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="TPP43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="TPP47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="280" mass="31876" checksum="005C646905B0C898" modified="2019-04-10" version="1">MTGKCTHVTLGNGVQVPQLGIGTWEAKNGNEVVQNIKWAINAGYRHIDTAHYYKNEKGVGQGISECGVPRSDIFVTTKLWNYDHGYESALAAFEQSRQALGVEYVDLYLIHWPGPNRSYIETWRAFEKLYEMKKVRAIGVSNFEPHHLDDLLANCTVPPMVNQVEMHPHFQQKALRAYCAEKNIAVTAWRPLGKGALLTEPQLVELAEKHKRSAAQVIIRWLIQLGVIAIPKSSHEERIKQNFDVFDFELSPEDMRRLESMDKNSRIGPSPETFFPTECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ83</accession>
    <name>A0A3Q8IJ83_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360023200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ83"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2330"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="310" mass="33672" checksum="00019FAD3AC84111" modified="2019-04-10" version="1">MGLLSSSSSSSSSAGTGAGAAAAQTDAQEVKRVDSLYNPHDVCEAAVDYVLRHVNTVQYMIQSIEEITGKPFLRDRIKCLPAVPRGEASCNSAMGLTPDRVLAGYMWRSARPDCQAKDVVLLEDHIARLFNTKHAAAFLKKDKAVNERAASPPTTSDATAAAASLPSTTATQSQLLRLLEGSQLPVLEQVERNIRHELVHAFDDARGAIESSDCVHQACSEIRAARLSGDCFVGQEMRKGRFNFFEGGQKCVRRRAVMAVDRNPVCRGFSERAVDTVFQKCYSDYEPFAAPIYALGSYGDSQFANGTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJL4</accession>
    <name>A0A3Q8IJL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360045300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tectonic family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJL4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360045300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5160"/>
    <dbReference type="OrthoDB" id="2104337at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF2">
        <property type="entry name" value="TECTONIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018609925" evidence="5">
        <location>
            <begin position="18"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="6">
        <location>
            <begin position="160"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="585" mass="63049" checksum="08EEAB6753D21F6B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK02</accession>
    <name>A0A3Q8IK02_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310019500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2070"/>
    <dbReference type="OrthoDB" id="267146at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1293" mass="136655" checksum="E2E8652D88D2354A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL77</accession>
    <name>A0A3Q8IL77_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_340032400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL77"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4060"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF81">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="76"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="277"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67057" checksum="33DC3825F4F9EED8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPJ6</accession>
    <accession>E9BUL7</accession>
    <name>A0A3Q8IPJ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_27510</name>
        <name evidence="6" type="ORF">CGC21_14825</name>
        <name evidence="4" type="ORF">LDBPK_365090</name>
        <name evidence="2" type="ORF">LdCL_360058100</name>
        <name evidence="3" type="ORF">LDHU3_36.6810</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP41960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865623.1">
        <property type="nucleotide sequence ID" value="XM_003865575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPJ6"/>
    <dbReference type="GeneID" id="13388509"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360058100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6810"/>
    <dbReference type="OMA" id="RSPELMW"/>
    <dbReference type="OrthoDB" id="268916at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599618" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="235" mass="26346" checksum="00D953A146A6782A" modified="2019-04-10" version="1">MSLLALNVCLISSSFDVVALPLSSTLCPVEVDDDVEDTSLCYGLAPLTEKGRKGYGYAHCTVMQFCARALDLKAVREIVRETWLKFRKHVLESKESLVLTGVADGPIFATTEDGRAVRLPNITVERSPNLMWLHETIVRELGQYQVKVGSEDVAKSAFHRKFPADSNSTTPEWMLSFMSKYAHENYTPHITLGACTEKNVAAFSFLQKTEIPWRECRLVVSHMGNFCSCFELLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPM3</accession>
    <accession>E9BSE2</accession>
    <name>A0A3Q8IPM3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_352720</name>
        <name evidence="8" type="ORF">LdCL_350032100</name>
        <name evidence="9" type="ORF">LDHU3_35.3470</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864851.1">
        <property type="nucleotide sequence ID" value="XM_003864803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPM3"/>
    <dbReference type="SMR" id="A0A3Q8IPM3"/>
    <dbReference type="GeneID" id="13387729"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350032100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3470"/>
    <dbReference type="OMA" id="MERANMD"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8379" checksum="7FD874FD8B5DD935" modified="2019-04-10" version="1">MVASSVPQGGTQEVTSHVQALMQQMQARFDEMSKCIVTRIDEMSTRIDDLEHSIDDLMQQSGTEQSDKPAARPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IRZ9</accession>
    <name>A0A3Q8IRZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300024300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IRZ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2610"/>
    <dbReference type="OrthoDB" id="264963at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="605" mass="66325" checksum="A87A1DB1BEA1219D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITM5</accession>
    <accession>E9BPA1</accession>
    <name>A0A3Q8ITM5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_35035</name>
        <name evidence="17" type="ORF">CGC21_21260</name>
        <name evidence="16" type="ORF">LDBPK_323510</name>
        <name evidence="14" type="ORF">LdCL_320041000</name>
        <name evidence="15" type="ORF">LDHU3_32.4440</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863762.1">
        <property type="nucleotide sequence ID" value="XM_003863714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITM5"/>
    <dbReference type="SMR" id="A0A3Q8ITM5"/>
    <dbReference type="GeneID" id="13391288"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320041000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4440"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="357"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5433108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ37079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="476" mass="50618" checksum="2B3E2BACA6DB8127" modified="2019-04-10" version="1">MFRRNIAHLASYDVTVIGGGPGGYVAAIKAAQLGLKTACIEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFAQYGLRGGENVTMDVSAMQAQKAKGVKALTGGVEYLFKKNKVTYYKGEGSFVNPNTIKVKGLDGKDETLESKKTIVATGSEPTELPFLPFDEKVVMSSTGALDLDHVPKKMIVVGGGVIGLELGSVWARLGAEVTVVEFASRCAANTDADVSKALTDALVKHEKIKIMTNTKVVSGTNNGSSVTIEVEDKDGKHQTLEADALLCSVGRRPHTTGLNAEAINLQMERGFICINDHFETNVPNVYAIGDVVNKGPMLAHKAEEEGVACAEMLAGKPGHVNYNVIPGVIYTNPEVAQVGETEEQVKKRGIDYKVGKFPFSANSRAKAVGTEDGFVKVVTDKKTDRILGVQIVCTAAGEMIAEPTLAMEYGASSEDLGRTCHAHPTMSEAVKEACMACFAQTINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IUR5</accession>
    <name>A0A3Q8IUR5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Amastin_surface_glycoprotein_putative/Pfam:PF0734 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340034400</name>
        <name evidence="3" type="ORF">LdCL_340034500</name>
        <name evidence="4" type="ORF">LDHU3_34.4350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IUR5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_044340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4350"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="195" mass="22196" checksum="0C123227F51F49C2" modified="2019-04-10" version="1">MGCKFTFLVYAILQLIAFLSVLIGTPLEMFRGTTRDPYNVSLCITLWGTKYDFQCHFIMYAQTTDGQWARCTTRRQHFRMAEALVVISIILYALAALLGFIMLFCCSLLRWVCLALNVVGLLTLGITWGLMVTEFNKGDGPLCPPLKNNYKFGYGFFLLLVAWVLDLVDIVFLLFPLPTMRSDESEKSNESVEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVQ2</accession>
    <name>A0A3Q8IVQ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360008000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVQ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0420"/>
    <dbReference type="OrthoDB" id="277128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31452" checksum="175CC002640552BF" modified="2019-04-10" version="1">MGDKVAHYHRKRHGGEGCRLQPSTCLSELASVVRCFDSRRLSSLRSLALLLLPFLYSVAAVSCWLSSSRSVDTHTHTESLTFCHRAMALSATSSSSSDDKIVNLLAIALQKVDDFKGKSADARHYASQVVAAVRANNNTEEEFRDQIICIVANVKNLNGELGAVPQERKPGISAAELATMDANAMRSRLQKRTMAATFRKRAREQTNVDKTSLHCTKCGLVRRDRLNINELALDSEESGSHFDYNFDNSCACSHSSDDERSSSGDEEDDDTATSKGSCATASDRHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H541</accession>
    <accession>E9B7Q7</accession>
    <name>A0A3S5H541_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">MFS_transporter_putative/GeneDB:LmjF.03.0410</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_030390</name>
        <name evidence="8" type="ORF">LdCL_030008900</name>
        <name evidence="9" type="ORF">LDHU3_03.0400</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858004.1">
        <property type="nucleotide sequence ID" value="XM_003857956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H541"/>
    <dbReference type="GeneID" id="13390379"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0400"/>
    <dbReference type="OMA" id="GLCQNFM"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17334">
        <property type="entry name" value="MFS_SLC49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="91"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="680" mass="74718" checksum="44327A95A9986886" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5C7</accession>
    <name>A0A3S5H5C7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_040013500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5C7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1010"/>
    <dbReference type="OrthoDB" id="266186at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123144" checksum="1DD16FDBF63B85F1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5J4</accession>
    <name>A0A3S5H5J4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050012100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0790"/>
    <dbReference type="OrthoDB" id="249905at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1630"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1641"/>
            <end position="1653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1724" mass="177817" checksum="814FA8D5946C03E3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H654</accession>
    <name>A0A3S5H654_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080010000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H654"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0570"/>
    <dbReference type="OrthoDB" id="266885at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="366" mass="37775" checksum="B3C23EEFB8382B32" modified="2019-04-10" version="1">MPPSRKVRHAAAVHEPRIPAKQQRQQQQQQQQRSPSPDHAVGKGSSASTSTSTGATARAAPRLRKGSLSRTSVTSSPVGASNPRRHASAATSWRAQLLHLATQEAYTAATLLRLLPSTAPADARDGVQPNQLLLGTAAPPPAPCGAGAAGGARVQTAQTARMARRSAYDASAPTAPAATTEAASPPTHTIKWTSYGELWEGLLARLPLVNGANDAAKPTPATGGNSDGNGITGGGKRCGGESAGHRGDKKAAVAAALAHGGAKAGDMNSPATDVSSMLSNDWRSFFLHRRLSGTATAGGRTCTAAPPQGHQAAARPQRRRLDNLTCSPYMTHAEQRAIRRYTAAAIASVPSGVRRGLSTICVLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H656</accession>
    <name>A0A3S5H656_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_080010300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0600"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF103">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1334"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="955"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1400"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="899"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1347"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1698" mass="174435" checksum="1F87BE4146030C4D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6W9</accession>
    <accession>E9BCN4</accession>
    <name>A0A3S5H6W9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome 26S non-ATPase subunit 9, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Proteasome_26S_non-ATPase_subunit_9_putative/Gene DB:LmjF.16.0290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_36380</name>
        <name evidence="8" type="ORF">CGC21_25210</name>
        <name evidence="6" type="ORF">LDBPK_160300</name>
        <name evidence="4" type="ORF">LdCL_160007900</name>
        <name evidence="5" type="ORF">LDHU3_16.0360</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859718.1">
        <property type="nucleotide sequence ID" value="XM_003859670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6W9"/>
    <dbReference type="SMR" id="A0A3S5H6W9"/>
    <dbReference type="GeneID" id="13393088"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0360"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000342">
        <property type="entry name" value="Putative proteasome 26S non-ATPase subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5428888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="257" mass="28384" checksum="8FACCA1166A2B646" modified="2019-04-10" version="1">MNGHSIEDIVEIEDYRAPAVESTIGDMDKEALREELRRLDAQKAALEAKLTDALQYLASTPVGLRGRLLDDEGFPRNDCDLYAVRTARNTADSTRNDLRVLNEKIYSLLNELHLQTQEEAQLQMVQDAAARRQRQAAAEKRAQRMAEVQRVSRLKPCLVVAKVDANSPAEEAGLSVGMQILQYGAVTQTELIAEGLQALARETSTHEGAPIAVWVRKPGELQDDPSELVLVPQRWQGPGLLGCALDMVGDEALCESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7H8</accession>
    <name>A0A3S5H7H8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_32725</name>
        <name evidence="17" type="ORF">CGC21_30815</name>
        <name evidence="14" type="ORF">LdCL_270018700</name>
        <name evidence="15" type="ORF">LDHU3_27.1890</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7H8"/>
    <dbReference type="SMR" id="A0A3S5H7H8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1890"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002430">
        <property type="entry name" value="Zinc finger protein family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="331"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5431245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="529" mass="59993" checksum="CF1D1783A4E57155" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7K1</accession>
    <name>A0A3S5H7K1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280033400</name>
        <name evidence="3" type="ORF">LDHU3_28.3810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7K1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3810"/>
    <dbReference type="OrthoDB" id="263077at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="466" mass="49070" checksum="E4B21B280F80F450" modified="2019-04-10" version="1">MPSPPTAAAPLGVATATLCGVAVDAPPSHATRAPTSSSSWLAADPCRRLRSSGDDVECIPSYETLLGAIRGARMPQGPPPLEGARPCSRSSSSSDASLSKLFPPWTAGGEGRQSCLEPTCGGAGFQTEASTPPASNAKRRFRDVETEDGGSRAGPDSSWPRAKHQRGEEAAVGSLTGAHPAPPMQEGGMRDPSGADSICGGGDVDVRPTLHTLSSEDDGDPWSARGGVCGFLTPLSTKLLCLPPVALMPLPPSQHLHARACRPASLLDREHAVPAWQVLASASTAAEEEQREGVGRVASTSSNTTLYTPARGNVHLRSAVDDAIVYSPLTLDDISPILCLSEERLAHRRMRVVECDRRPSAEVDDEEHWADEAFAATSPSTPPRPFRALTPAESRGDEEDISGMAPDLPTQYPAGSVCFLHEEALRLLTFTCEDEHDHLLQRPGEGSGRGASCRCGSDLGKSPCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7W8</accession>
    <name>A0A3S5H7W8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_340026800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3250"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001177">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000704">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="911"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="783"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="878"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1235"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU82546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1467" mass="158357" checksum="27DB04BE648E5CE6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQK7</accession>
    <name>A0A3S7WQK7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinetoplastid kinetochore protein 10, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein kinase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_8280</name>
        <name evidence="11" type="ORF">CGC21_18340</name>
        <name evidence="10" type="ORF">LdCL_090009600</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000045">
        <property type="protein sequence ID" value="TPP41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQK7"/>
    <dbReference type="SMR" id="A0A3S7WQK7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090455.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0570"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF20">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="133"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="469" mass="53210" checksum="F4B3FBE1FDDFBE7B" modified="2019-05-08" version="1">MDSSSAAADAGGAAARSGLHVYSSAQANAAGSGTAALPNKALDHMKHMSRSKSDARRSGSKRTFDEATATDNVQLRRHDGTAVPNTAPNQVVEVVAPPPKKKKVTYALPHQNMEEGHFYVVLGEDIDVSTQRFKILSLLGEGTFGKVVESWDRKRKEYCAVKIVRNVPKYTRDAKIEIQFMEKVRQADPADRFPLMKIQRYFQNDSGHMCIVMPKYGPCLLDWIMKHGPFNHRHLAQIVFQTGVALDYFHSELHLMHTDLKPENILMETSDTTVDPATNRHLPPDPCRVRICDLGGCCDERHSRTAIVSTRHYRSPEVILGLGWMYSTDMWSMGCIIYELYTGKLLYDTHDNLEHLHLMEKTLGRLPSEWAARCGTEEARLLYNSAGQLRPCTDPKHLARIARARTVRDVIRDDLLCDLIYGLLHYDRQKRLNARQMTTHPYVLKYYPEARQAPSYPDNRAMLRPPPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQT5</accession>
    <accession>E9BA08</accession>
    <name>A0A3S7WQT5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_7920</name>
        <name evidence="5" type="ORF">CGC21_36770</name>
        <name evidence="4" type="ORF">LDBPK_091230</name>
        <name evidence="2" type="ORF">LdCL_090018700</name>
        <name evidence="3" type="ORF">LDHU3_09.1460</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858801.1">
        <property type="nucleotide sequence ID" value="XM_003858753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQT5"/>
    <dbReference type="SMR" id="A0A3S7WQT5"/>
    <dbReference type="GeneID" id="13392135"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1460"/>
    <dbReference type="OMA" id="IPANIAW"/>
    <dbReference type="OrthoDB" id="271800at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="196" mass="22169" checksum="3222FD2291F45910" modified="2019-05-08" version="1">MSNEEVFRISNVSGYSVEMPLATAKELLGMLNMDQVFRAARAGTDDTDESDVDDGDTEPVKAEGTDYSKEVLDVVRAYALLPPDERTSSIPRPLTQDLRSVVYAGEMELVEKAEREDYLVDLLNCALFLRFSQLSALCAAYMAVRIDEIAKAAPDIMEGAERIRKFLHMQNEWTEEEMGHLRREMEYAKSVDPNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR58</accession>
    <accession>E9BAA7</accession>
    <name>A0A3S7WR58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_23560</name>
        <name evidence="3" type="ORF">LDBPK_100620</name>
        <name evidence="2" type="ORF">LdCL_100013000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858898.1">
        <property type="nucleotide sequence ID" value="XM_003858850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR58"/>
    <dbReference type="GeneID" id="13392225"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0940"/>
    <dbReference type="OMA" id="QLAHYFG"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001131">
        <property type="entry name" value="Zinc-binding dehydrogenase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="59"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="478" mass="51055" checksum="10C7BF29C645BE11" modified="2019-05-08" version="1">MGHKNSSNISSAPVPPPFYVLPAVPVPSLKPSNLDFSETSGKPILCAGWIAPHGNRSWSRRNVVYSSEIEVPVPQPCQVRVKIYAAGVNPVDAHRTAVLTSFPEVGTSGKSRCASRHPRPPFKFPYVVGIEGAGVVESVGWAAASSGERDGSAGAPASANARDIRVGDRVAFLADFTQGSGGTFCQYAVVDSDVLWKLPEVVCAPPPSTDGLVPGRLIDFVEAASLPAAAATAYIALFDKLRIETQRAIFISGASGGVGSAAVQLAHYFGLYVIASCSTPNMRYVQSLGADYVVDYTRADVVKEILTYTDNYGVDYLLECAGASMAEAHSETVRFGGALCVLTGLLSPRSDMVFRRQLSVHYVCLGMQHQDPLARTQLQPLGELVMQLYIQGAFSVNAEQVPFVQAADALDVVALGHGRGKIVLTNFHTNEDKEERLRRRHVQLYEKAQRQYQLEETQKAAGAAAAAAASDAASREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRH5</accession>
    <accession>E9BAK9</accession>
    <name>A0A3S7WRH5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_30685</name>
        <name evidence="11" type="ORF">CGC21_1100</name>
        <name evidence="9" type="ORF">LDBPK_110210</name>
        <name evidence="7" type="ORF">LdCL_110007000</name>
        <name evidence="8" type="ORF">LDHU3_11.0240</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858999.1">
        <property type="nucleotide sequence ID" value="XM_003858951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRH5"/>
    <dbReference type="GeneID" id="13389505"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0240"/>
    <dbReference type="OMA" id="PSYRVKY"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000860">
        <property type="entry name" value="Acidocalcisomal pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000012">
        <property type="entry name" value="Acidocalcisomal pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP39808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="443" mass="51034" checksum="BB670B30FE7C5CED" modified="2019-05-08" version="1">MSDGTRYMYPARKAHAMDLGSSLNPEGDQKQTWGSVASIADVMSPTAEIKPSAPQVTHFGTGLGMQSSTGDLALQEADSDGDKTEVVNEFDLAAYSKEDLTQTLHKRIMSRMFSAFDVTQVGYLDINKLKELCVYVGRNMSQEASEKMFDELKGIDGHITFDVFWNWWTTYPDTKMTKDTFSLVSADFSVPYHQQQLKIKEEGEIFTPSYRVKYYFKDMETGLRRRVSPWHDVPLYVRDPVRTKPENIRANRYNFICEIPKWTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGAFPQTWESTEVIFEDGVSGDNDPIDGVEIGMRQMRVGEIHPVRILGVLGMIDDGQMDWKVICMSVNDPVARFIRDIDDIPKFLPGCLDALREWFRVYKICQGGVENKFAFNGEYKDKTYAMKVVDESHYMWENLRKIKKKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSE8</accession>
    <name>A0A3S7WSE8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_130010300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSE8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0660"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF46">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="12">
        <location>
            <begin position="157"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32147" checksum="99848B79EBDFE184" modified="2019-05-08" version="1">MPSALRCHSTTAADASAKAKLTSPGAPLTHVLKPIPTSGAASSFSVTPSAVVLHTSYASLSAVDEVGHDESRSRGADAGDGPTRTAHLTATPSYAVTNVAAFEQLIAEALRLSEVTLEAAATVAAPPAPSPSSPVLATSASRGSAREAPITLIADHTVRELQVLLAEAERTLAPFTARKARIDKFVYGVYLPLLKYGTFAFFAAQLVVYFNWIFFVFDWNLVEPTTYFLAYTGIFCSLVYHYYHCSGDGSTWKDMFQHLARRKAEKKYAQVQLDVVGMAQLQRRITLIEKELARMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTE4</accession>
    <name>A0A3S7WTE4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_150009800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTE4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150009800"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8025" checksum="91C95715872B45FC" modified="2019-05-08" version="1">MGAGLEVLPLVTSIENAGSSAGLSLVRGVAPKPEPEPEPSVVLPGACWVASCPATPAPAKAVALLATAVADDGSMASATEIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTM8</accession>
    <accession>E9BCJ0</accession>
    <name>A0A3S7WTM8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_1255</name>
        <name evidence="14" type="ORF">LDBPK_151510</name>
        <name evidence="13" type="ORF">LdCL_150020400</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859674.1">
        <property type="nucleotide sequence ID" value="XM_003859626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTM8"/>
    <dbReference type="GeneID" id="13392973"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1830"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP47669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="458" mass="48859" checksum="A4E868B10D83629E" modified="2019-05-08" version="1">MEASAPGKVLILGSYLIVESCTPANVGVSIGVNARFTTRIVKAESTTAGASGKTTMHMNSPQFRQSFCFVADTSAPGIVAVKQTEGSGSPFIFNAVLYSVAAAQSLGSSTDGEIWVELLADNNFYSQRNYLESQGKDVNVANLRALPPHLPLVGAVSKTGLGSSAAMTTSIVACLCHHFNADGCSHEYVHRIAQIAHSVTQGKIGSGFDVYTAVYGTCAYRRFPASRVSMMMDSAQPPSSVEVETLRRCVDMKEVWVPPEPFRLPPGVKLVLGDVHQGGSSTPGMVAKIVAWRRSVADTPDNLWEQLRRNNEAYIAALRRMIDEAAAKPDVYAASMAALQQVPSLPLFKADGESMQCIVEASRCAARSRALLRDMGLAAEVKVEPVELTDLLDDTATLPGVFAVGCPGAGGYDAVFALVLGDECAAAVEVFWEHYTKMNVCPLLVREDPSGLLVQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTR0</accession>
    <name>A0A3S7WTR0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160006500</name>
        <name evidence="3" type="ORF">LDHU3_16.0180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTR0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0180"/>
    <dbReference type="OrthoDB" id="272612at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="235" mass="25212" checksum="2C8E5C23EB66ED2E" modified="2019-05-08" version="1">MHSSTARNHPLATLGAFASYPLLRALLHGAMPLKKKEEVCGKPNQYNLNTLEYDWRELPDTHIQVPPPQPCVRDYSALAGYGAAGNRVNPITHQPLPSHGARFGGVGAVSPTPLPSPSRPVQEAMRRAPSPQAHHDNRDHVADLFGDGDGGAGQRPEREPQRRALPPPLVAGESPQALPYPSSGVNGRGDAVHGNAAASPSGPYGADAFNVVWSHEDIKRAVHTNSLEAHRSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU53</accession>
    <accession>E9BCZ6</accession>
    <name>A0A3S7WU53_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_36870</name>
        <name evidence="6" type="ORF">CGC21_24705</name>
        <name evidence="4" type="ORF">LDBPK_161440</name>
        <name evidence="2" type="ORF">LdCL_160019400</name>
        <name evidence="3" type="ORF">LDHU3_16.1720</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5429002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP41023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859829.1">
        <property type="nucleotide sequence ID" value="XM_003859781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU53"/>
    <dbReference type="SMR" id="A0A3S7WU53"/>
    <dbReference type="GeneID" id="13393156"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1720"/>
    <dbReference type="OMA" id="CEPISFI"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="108" mass="11643" checksum="EA8A8334C2F31601" modified="2019-05-08" version="1">MATNGNRHASDAGAAEGHPFLGRELRVELTDGRVIVGTLIAYEGSGDLLLQAAVEQRMYKDGEVTMRGLNLLAIPFKHVKGLHRRRPGLGPIVLTSGEAERETPALMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV49</accession>
    <name>A0A3S7WV49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_180022000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV49"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.2140"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12464" checksum="36AA24DB301BF819" modified="2019-05-08" version="1">MQSTIHFQEAYDAMPPALIGTSSYSFQRADWNLQRTVIKKSSLQVRVCRSNGETKTRKVPTTAMTTISTTPQRIHSCIASLVDTVKVITITNHHQVPCPGYYSCFWTVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWF0</accession>
    <name>A0A3S7WWF0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210011600</name>
        <name evidence="3" type="ORF">LDHU3_21.0710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWF0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0710"/>
    <dbReference type="OrthoDB" id="239498at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="CDD" id="cd23745">
        <property type="entry name" value="RESC17_18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="536" mass="57120" checksum="9C064F52E20989D8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWV6</accession>
    <accession>E9BFL0</accession>
    <name>A0A3S7WWV6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_16805</name>
        <name evidence="4" type="ORF">CGC21_32950</name>
        <name evidence="3" type="ORF">LDBPK_220003</name>
        <name evidence="1" type="ORF">LdCL_220005200</name>
        <name evidence="2" type="ORF">LDHU3_22.0060</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5429963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860741.1">
        <property type="nucleotide sequence ID" value="XM_003860693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWV6"/>
    <dbReference type="GeneID" id="13389626"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220003"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220003.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0060"/>
    <dbReference type="OMA" id="YNRVCAT"/>
    <dbReference type="OrthoDB" id="275105at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5429963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="144" mass="15804" checksum="B07AE96CA0190508" modified="2019-05-08" version="1">MSSTEPPAVPVKVVVDCKEVGVTIDLHSPPTASNFLAYNRVCSTLDSDYLMQPINEAQYDSETQACVDRLSNGPTSFYDHYVRKPTRKRGLAVGCESPMEHIGVSDDFLMPPTQRDLPAACVKGGIFSDPLTRRLATGRMPSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX60</accession>
    <accession>E9BFS3</accession>
    <name>A0A3S7WX60_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin 5-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Prefoldin, alpha subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Prefoldin_5-like_protein/GeneDB:LmjF.22.0670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_16535</name>
        <name evidence="4" type="ORF">LDBPK_220540</name>
        <name evidence="2" type="ORF">LdCL_220011700</name>
        <name evidence="3" type="ORF">LDHU3_22.0870</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860804.1">
        <property type="nucleotide sequence ID" value="XM_003860756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX60"/>
    <dbReference type="SMR" id="A0A3S7WX60"/>
    <dbReference type="GeneID" id="13389369"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0870"/>
    <dbReference type="OMA" id="RNTEQGQ"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000032">
        <property type="entry name" value="Prefoldin 5-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="157" mass="17900" checksum="28BDCA5F86691CD0" modified="2019-05-08" version="1">MSINVYQLPIEQLEGLKEQLDNDVRSLGTAYDGLYNGRTRYQDNHDVVAQYHAVCENAAKTEAAQEVLVCMTSSLFVRGTVVPSDKVLVDVGTGYFLEQSMEHAKKYFLSRAAQIKESMDQVEKTIVLKQRQQNQVIDALQQKTMAMQRYHEEHGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXH7</accession>
    <name>A0A3S7WXH7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_230005100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXH7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0040"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="383" mass="42784" checksum="941C6658DEBA730E" modified="2019-05-08" version="1">MCKEFVASAEATGLIASLYIVDYMRKQDNVAAKSTFYDVLIELEHAIRRDMFVVEQIKYTTKESKEGKKSLEATRAEVFRIHCAAKVFAFQLLGDTVADDEKVVSYASKKQDSIDEALNAWEKASIKIKEPMADIEHCWVAKHEKQQCGSLYETAAVFDEQPNKLFALLLPSVTAKLPMLPMQEGELQYLLPGKSAMLLLDSAPPSEGWMISKRLLVEARKSKLSKDDEQTLLGLLNESLVSRLGVSPQQLSELATHSPGVCASVLLKVPSGSAGAFIQFLLKGNIPEDNMQAILLRASSVLQQVNVRTFISTMLHKLKERCGLPSAAESLKSFAVTLHQLVMKAAKENREIFIADTFRADLEQLFQSSNIPEVKNRWEEMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0D8</accession>
    <name>A0A3S7X0D8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_270008200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0D8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0410"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306:SF0">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="4">
        <location>
            <begin position="123"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="171"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="736" mass="81977" checksum="4DD48978E12C8038" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X218</accession>
    <accession>E9BKG1</accession>
    <name>A0A3S7X218_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_25990</name>
        <name evidence="12" type="ORF">CGC21_27625</name>
        <name evidence="10" type="ORF">LDBPK_290140</name>
        <name evidence="8" type="ORF">LdCL_290006300</name>
        <name evidence="9" type="ORF">LDHU3_29.0200</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862432.1">
        <property type="nucleotide sequence ID" value="XM_003862384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X218"/>
    <dbReference type="SMR" id="A0A3S7X218"/>
    <dbReference type="GeneID" id="13387170"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0200"/>
    <dbReference type="OMA" id="DETKFHF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5431723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP52650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="337" mass="37566" checksum="161D7154563F466E" modified="2019-05-08" version="1">MKLEIVECVKNEHAAGETLTFQLSEVDSSFANALRRVMLAEIPTLAIEYVTIRQNTSVLPDEMIAHRLGLVPLFSEKAKRLNFPQDCGCGGSGCPDCQITGSLKVQCPPNQHSKQVFIGDSLQIDDAEVYPVSAEEHGIWLVTLGRSQVLDLHVVIRKNIAKTHAKFMPVATVAMRYAPEIILNPNGFQTLGKAKAREWVARCPRNVFRFVERTGQVEVQDEDACIFCRECTSQEPPFDRLPEPLVFVRQKKNKMGYFDFTFTVESTGVLPVLQIVYDAVTVVRRKLQRVSEGLMKDPNADGVKTRTIGQSTTAPVVPNADAVRKGAEEDNLDFTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2X5</accession>
    <name>A0A3S7X2X5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_300007100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2X5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0330"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.480:FF:000010">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="374" mass="41081" checksum="250E917AC07FAF6D" modified="2019-05-08" version="1">MPKEPRAVPMGIISAEPIHAASCKIKFGTKTITLGKSTPQGHRRGTAAEGLKEKRASSGVKTGGSQSGIVFNKGFGQHILKNPLVIAAIVEKAAIKPTDIVIEIGPGTGNLTEKLLQTAKKVIAFEIDPRMVAELNKRFQNTPLASKLQIIRGNCLEQDFPYFDKCVANVPYAISSALVFKLLKTPTFKCAVLMFQREFALRVCAQPGSEAYCRLSVNSQLLARCSHLMKISKNSFNPPPKVESSVIRLDPKHPRPDVDFEEWDGLVKMLFSRKNKKSSSIFRTKAAVQALYDKYVSYRKMEGGQPVGTATSGAKPLTSSSSADVGSSVSLEQFRVLLDSVIADPMFEKRSRMLDEEALMTMLAHFIKHGIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3U4</accession>
    <accession>E9BM74</accession>
    <name>A0A3S7X3U4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeats (3 copies) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_36340</name>
        <name evidence="6" type="ORF">LDBPK_303310</name>
        <name evidence="5" type="ORF">LdCL_300038700</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863042.1">
        <property type="nucleotide sequence ID" value="XM_003862994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3U4"/>
    <dbReference type="GeneID" id="13385751"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300038700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4400"/>
    <dbReference type="OMA" id="NDARMTY"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000482">
        <property type="entry name" value="Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000483">
        <property type="entry name" value="Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP45877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="411" mass="45509" checksum="79888CB315105BAA" modified="2019-05-08" version="1">MNFGVIGGQQGPKALLDAVQQAVRDGNLEALRRLSKEFLAISDNVEKCRDENGNTIVHLALGKNTTTLEYVIESLHANVNATNAQGRTPLHEAVTRDYIACCQVLLDHGADDTIQSTTQSTPFHTAAACGSIEGMEVILRHSDNPEVKVNELDRQRSSALHKCAFDGDVRVSRWLVEHGANVDATDSTDATPLLIAVKMGQTEVAEYLLRNGADCNRQDRQGNSGLHFCAVRGDVKAAQLLLAAGANPCLLNEEYDTPLHIIARNSRLDSGAWEMVGLLLMAGCDPLQVNASNKKPSDYVSRGLKKMFTKEEVEQRLRREAQLQEESDAELSRAWEQCAQWKTKVLENISSRRLVEAAEDARLAREKEERIRAANDARMTYDEALAKCQFLEAEIQRKKAMLEKTLTKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3Z2</accession>
    <accession>E9BM95</accession>
    <name>A0A3S7X3Z2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_36450</name>
        <name evidence="7" type="ORF">LDBPK_303520</name>
        <name evidence="6" type="ORF">LdCL_300040800</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863063.1">
        <property type="nucleotide sequence ID" value="XM_003863015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3Z2"/>
    <dbReference type="GeneID" id="13385772"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300040800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4680"/>
    <dbReference type="OMA" id="SSRIYGC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="144" mass="16333" checksum="E0872324769E0739" modified="2019-05-08" version="1">MVRRLRTRLAAPSGGEGGFGCAFCGAHLCIAEDIVSDNFRGRHGKAFLVSRCENTYYGHQEEKQLMTGLHRVRDVFCSNCDQYVGWGYDFAVDEREMYKMQRFVLERQLIRVITHGQLRGALGYSIPEGSITFALPVARSYTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4Q3</accession>
    <name>A0A3S7X4Q3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal tRNA ligase phosphodiesterase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_310029900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4Q3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3900"/>
    <dbReference type="OrthoDB" id="277779at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003049">
        <property type="entry name" value="Fungal_tRNA_ligase_phosphodiesterase_domain_conta ining_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057680">
        <property type="entry name" value="DUF7920"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25536">
        <property type="entry name" value="DUF7920"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7920" evidence="3">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7920" evidence="3">
        <location>
            <begin position="381"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="846"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="929" mass="103088" checksum="E521CF2AD4ACD022" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4W0</accession>
    <name>A0A3S7X4W0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310035800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4890"/>
    <dbReference type="OrthoDB" id="273222at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1316" mass="143132" checksum="B7B2DFADEC4F0443" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X692</accession>
    <accession>E9BPG0</accession>
    <name>A0A3S7X692_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_35330</name>
        <name evidence="4" type="ORF">CGC21_21535</name>
        <name evidence="3" type="ORF">LDBPK_324110</name>
        <name evidence="1" type="ORF">LdCL_320047100</name>
        <name evidence="2" type="ORF">LDHU3_32.5280</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863821.1">
        <property type="nucleotide sequence ID" value="XM_003863773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X692"/>
    <dbReference type="GeneID" id="13391584"/>
    <dbReference type="KEGG" id="ldo:LDBPK_324110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320047100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5280"/>
    <dbReference type="OMA" id="NTIIRAW"/>
    <dbReference type="OrthoDB" id="269275at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5433175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="185" mass="21766" checksum="3F5E43627F7E32DC" modified="2019-05-08" version="1">MLRQLSIRQAPKVELISPTPSAPIQNFDLRPIAASLLYRKLLKLYLRKFDTDTNTIIRAWKQTKYEFWVHRNVSKEEADLLNIKGQQVLEAIRAGLVPVYHNSKTNQTYYKYDADTLNAVHNHVDPVSAEEFLRRFHDRMDSRDVEEIKATLKKLGRWTGPDELRKEDLFRVKTKRKVKCTDPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7C5</accession>
    <accession>E9BPS4</accession>
    <name>A0A3S7X7C5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_9740</name>
        <name evidence="6" type="ORF">CGC21_5535</name>
        <name evidence="5" type="ORF">LDBPK_333370</name>
        <name evidence="3" type="ORF">LdCL_330041400</name>
        <name evidence="4" type="ORF">LDHU3_33.4880</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000051">
        <property type="protein sequence ID" value="TPP42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864160.1">
        <property type="nucleotide sequence ID" value="XM_003864112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7C5"/>
    <dbReference type="GeneID" id="13392556"/>
    <dbReference type="KEGG" id="ldo:LDBPK_333370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4880"/>
    <dbReference type="OMA" id="FMFMCDT"/>
    <dbReference type="OrthoDB" id="10265007at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000472">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF4">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="534" mass="60172" checksum="6B1B8161D0BBBEB4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7S0</accession>
    <accession>E9BQV7</accession>
    <name>A0A3S7X7S0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_26105</name>
        <name evidence="3" type="ORF">LDBPK_341560</name>
        <name evidence="2" type="ORF">LdCL_340021900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864318.1">
        <property type="nucleotide sequence ID" value="XM_003864270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7S0"/>
    <dbReference type="GeneID" id="13392727"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2390"/>
    <dbReference type="OMA" id="EIMMRMY"/>
    <dbReference type="OrthoDB" id="272249at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="705" mass="77132" checksum="D44183C67E1448F4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7X9</accession>
    <name>A0A3S7X7X9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340027500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7X9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3380"/>
    <dbReference type="OrthoDB" id="266850at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1079" mass="112323" checksum="920800B992CDEDCB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8K8</accession>
    <accession>E9BRL6</accession>
    <name>A0A3S7X8K8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sjogren s syndrome nuclear autoantigen 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sjogren_s_syndrome_nuclear_autoantigen_1_putative /GeneDB:LmjF.34.4540</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_344170</name>
        <name evidence="2" type="ORF">LdCL_340051800</name>
        <name evidence="3" type="ORF">LDHU3_34.6550</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5434018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864577.1">
        <property type="nucleotide sequence ID" value="XM_003864529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8K8"/>
    <dbReference type="SMR" id="A0A3S7X8K8"/>
    <dbReference type="GeneID" id="13387455"/>
    <dbReference type="KEGG" id="ldo:LDBPK_344170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_344170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340051800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6550"/>
    <dbReference type="OMA" id="ETKNEYD"/>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11875" checksum="D16909AA1DD1A804" modified="2019-05-08" version="1">MAALGSDVQATSVELVSVIEKMKERKTLLEEQIAAEEAEYEGVLAEVRAMQERLSALKDSLAKKQAVRADLERTISETYSAFKSILDASKKLLSTAKEESSVLKAQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8W5</accession>
    <name>A0A3S7X8W5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldose 1-epimerase, putative</fullName>
            <ecNumber evidence="4">5.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_350014700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8W5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1200"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000045">
        <property type="entry name" value="Putative aldose 1-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="371" mass="41604" checksum="4E7B382FA3C35B49" modified="2019-05-08" version="1">MQFGIRVEPYGYDKLVWLETDVLKVGLTNYAASVASIQVYHPADNKWIEVNCGYPKNPEEAYADPDYMGATVGRCAGRVAGGVFTLDRVKYYTQKNRGENTCHCGDDAYHKKHWGMKLIETANVIGVRFNYTSPHMESGFPGEVKNYCTFTIDRSNPNALKTIYDSYITDNSPCDASPINVFSHTSFNLNGIPGQQDGEKNWVQPESVRNHWLRVPASRVAEADRMAIPTGEFLSVEGTGLDFRQGRVIGDCIDDVALLDRDPCGYDHPLAIDGWEKGKLMLHAEAKSPVTNICMKVYSTFPCMWVYTANNKPLPASGGPGQRYARWTGLLVGPQNFSDVANYYPKYPSCIVRRGERQYSETTINEFTIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X926</accession>
    <name>A0A3S7X926_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350018500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X926"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1790"/>
    <dbReference type="OrthoDB" id="266207at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="317" mass="32698" checksum="CB3266DAAD734A75" modified="2019-05-08" version="1">MADSHSTSAAPAASSPCSVYRLKHNPSWTKFGMHPAMLADINARSGRPTSRRASSCGSSAANSAVPSASASLLSTASARQPASSGSLAAVGAQAALRHEHKQAHAASRSMSLRATAFNASGIRGVSQSLVSDSAFSTSRARGGSDVKARAPESASLSQPAATRGESPAASAPVSTTFRDKGGSCDHGTETPRTPNDTRSSDFTDSSWRAETTRDPSLQPSVLPLREASSSRAKDSHLMGSAALVEVAGPLDALYVPLRRPAPRGCVATRQHFSIFERTHCQGVPVRSATEARAAVAAHRVAHIGHRGVVGGSPETDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9A7</accession>
    <name>A0A3S7X9A7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350029200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9A7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3090"/>
    <dbReference type="OrthoDB" id="272537at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1276" mass="134968" checksum="941E54BA91732766" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9W3</accession>
    <name>A0A3S7X9W3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350050700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350050700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6000"/>
    <dbReference type="OrthoDB" id="266882at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1483" mass="156581" checksum="FB55C4738445397E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBD2</accession>
    <accession>E9BUA4</accession>
    <name>A0A3S7XBD2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_28025</name>
        <name evidence="9" type="ORF">CGC21_14255</name>
        <name evidence="7" type="ORF">LDBPK_363960</name>
        <name evidence="5" type="ORF">LdCL_360046600</name>
        <name evidence="6" type="ORF">LDHU3_36.5300</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865510.1">
        <property type="nucleotide sequence ID" value="XM_003865462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBD2"/>
    <dbReference type="SMR" id="A0A3S7XBD2"/>
    <dbReference type="GeneID" id="13388396"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360046600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5300"/>
    <dbReference type="OMA" id="GGQWIAS"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000005">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="103" mass="11636" checksum="B9CD19A717D7DEB1" modified="2019-05-08" version="1">MPITQEQLKRRAEMVRTGGKGSMRRTTKAHHKSTGDDKKVQVTLRRLGVTPFSDIDEAVFYRQDGSAYYFSKPKVQASMQTQCFVVSGDYDVKSADEVDAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBE7</accession>
    <accession>E9BUD5</accession>
    <name>A0A3S7XBE7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_14415</name>
        <name evidence="7" type="ORF">LDBPK_364270</name>
        <name evidence="6" type="ORF">LdCL_360049800</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865541.1">
        <property type="nucleotide sequence ID" value="XM_003865493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBE7"/>
    <dbReference type="GeneID" id="13388427"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360049800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5710"/>
    <dbReference type="OMA" id="ERIPCAV"/>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600703" description="Serine/threonine-protein phosphatase PGAM5, mitochondrial" evidence="5">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP48533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="347" mass="38724" checksum="DCEECD660D927233" modified="2019-05-08" version="1">MSFTFRRFLCSVGIGFAASPLLRGAAVALCETVKPAAPPGMGSAAHISANGLANHLFDEDPLPTKEELQYVKTWGVPWVEDWDRPGNRGIRADRSASHQRQVIMIRHGQYGNEGVNDDKIHRLTPLGERQARETGVYLRRLFEESDKRKKLNAIYRQARRAYKQAKNDGASEEQLTQLERKMDEARLVLCGAGGILVDAMPMAVHVSDMTRAKQTADLILEAFPEDVRLRKDVDPQLRERIPCAVQPVRPFTPSAEDMHVAEAVFERYFHRPVESGTSVEIIVGHANMIRYLTMRALQLPPEAWLRTSLPHCSVTTITIRGTGHVSLVGMGSYGHLPPDMVTVSNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBM8</accession>
    <name>A0A3S7XBM8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360054100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBM8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360054100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6320"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF682">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="277"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="789" mass="85501" checksum="EAB6D7E1E0DB19E9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBW4</accession>
    <name>A0A3S7XBW4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat protein (LRRP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360067800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBW4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360067800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7970"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF19">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="256" mass="27888" checksum="B493A9065F2BAC16" modified="2019-05-08" version="1">MLHKDAEHRLTEDDCLTSSQQYEPQLIFHVPLRRKGYQAIDANAFVRCGGLRVVDISGNRLSSLSGLESVAPQLTFINAAENCLHDISALVTCAALERCMLEGNKLASVGSLQPLVPLPCLAELVLQRHVPLDGTDTDLGSPQQSPDRLLLLDNPVCRDAVAYREHFLARVSHVRWVDGVSAYLRASSLAESTTAEAHDATANSTKAIVDAAIRSFQSIRVQMTATVSEETTLRRQLERAADRCKPSTATVAARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XCB2</accession>
    <name>A0A3S7XCB2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ESF1 RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360080600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XCB2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360080600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9080"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="2">
        <location>
            <begin position="54"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="622" mass="69588" checksum="E8DAB0C543825E35" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7C7</accession>
    <accession>A0A3S7WNK4</accession>
    <name>E9B7C7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-damage inducible protein DDI1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_010630</name>
        <name evidence="6" type="ORF">LdCL_010011300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857876.1">
        <property type="nucleotide sequence ID" value="XM_003857828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7C7"/>
    <dbReference type="GeneID" id="13389784"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0710"/>
    <dbReference type="OMA" id="VIEDQAM"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="PhylomeDB" id="E9B7C7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartic peptidase DDI1-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU75574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ31150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="243" mass="27002" checksum="290C1EA0A0AB01E4" modified="2011-04-05" version="1">MDERQLELQRRIYAQIQQQQIDENLANALEYTPEAFAKVAMLYVPCTINQVLVKAFVDSGAQNSIMNKRTAERCGLMRLVDVRMRGVAVGVGRQEICGRIHMTPVNLAGMYIPFAFYVIEDQAMDLIIGLDQLRRHQMMIDLKHNCLTIDNINVPFLPENDPPALTALDDDENAMHAPRHQDPAATAIPASIPAAPVLSEGERQARIEGFMTFSGITDPTQAAELLEAADWDPNVAAALLFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAS3</accession>
    <accession>A0A3S5H6J1</accession>
    <name>E9BAS3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_110850</name>
        <name evidence="4" type="ORF">LdCL_110013900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859061.1">
        <property type="nucleotide sequence ID" value="XM_003859013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAS3"/>
    <dbReference type="ESTHER" id="leiin-a4huz4">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="GeneID" id="13389539"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1050"/>
    <dbReference type="OMA" id="MMTTSWG"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="PhylomeDB" id="E9BAS3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="472" mass="52397" checksum="0A40D09181221724" modified="2011-04-05" version="1">MRFTDRVSFAVKHVVVHVFFYWLPRLVFGALSRWPRWLVSRLTRGKLVAEPPDEREVTLIANEKDPYRLRRRFGLPLTGQPPLRYHAPLYNGHIHTILAAMRSGPRVPYERELVESYEGQHVNMDYLYPPPSSDPTSSTPATAATSPFAGSTGSAKGRAPQAKGLIFIVPGLLNASTTNYVRHFAVKSVEAGFAVCVLNSRGMGTTPLEVPRLFSATFTEDIRYCLHHYLQQKQVQERLGTPRPVPLIAVGFSLGGVTLIKYLGEQGMAAAENELRSNLPPNSAAPDTPVSALVTVTCPYDLIEADRMSATLLYRCLYEKSFAVGLRKYAKHNREMLAKLPNVDSKMLFEGPSPVIDRLTSIRAFDKYINASHNGFNSPQEYYAAAQPLLWLPRCRTPILCIGDRNDVVAGGFVPDASWRALVSENPYTVYVCYPVGGHLGFLGTPAAEWRGDASEAEHLVLRAATKFCETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBD8</accession>
    <accession>A0A3S7WSJ5</accession>
    <name>E9BBD8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_130640</name>
        <name evidence="2" type="ORF">LdCL_130011800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859275.1">
        <property type="nucleotide sequence ID" value="XM_003859227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBD8"/>
    <dbReference type="GeneID" id="13390465"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0830"/>
    <dbReference type="OMA" id="HYEEGMH"/>
    <dbReference type="OrthoDB" id="247552at2759"/>
    <dbReference type="PhylomeDB" id="E9BBD8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24659" checksum="FB1D27FC0879B9A0" modified="2011-04-05" version="1">MFHRHSFYNKGSSAPRDGAGAGADGKQAHGNAAGGSWNNGSSSSSSTASSQQQREQDERLYGMGSATAQQRRQVRQQWEKSFFGRLHYEEGMHDRFAEALKSEDEEAFRQSIAGQSHADLFPHWPEEEEAPLSEFKRLRPSLQLHYIVNRLSSGERRIRYSVDFGGLLMMPQLNLGEMMVKEAGTLLRELGWMNDEVAARIEEVQALAFKIKFDFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBM0</accession>
    <accession>A0A3S7WSM9</accession>
    <name>E9BBM0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich repeats (2 copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_131470</name>
        <name evidence="4" type="ORF">LdCL_130018900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859357.1">
        <property type="nucleotide sequence ID" value="XM_003859309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBM0"/>
    <dbReference type="GeneID" id="13390793"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1630"/>
    <dbReference type="OMA" id="VVHHNQL"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="PhylomeDB" id="E9BBM0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="625" mass="66606" checksum="81B6A2D0DD997139" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E9BC93</accession>
    <accession>A0A3S5H6U4</accession>
    <name>E9BC93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Katanin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Metalloprotease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_150520</name>
        <name evidence="6" type="ORF">LdCL_150010300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859577.1">
        <property type="nucleotide sequence ID" value="XM_003859529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BC93"/>
    <dbReference type="GeneID" id="13392927"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0670"/>
    <dbReference type="OMA" id="SKAPPYE"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="PhylomeDB" id="E9BC93"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="711"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1002" mass="105876" checksum="5E8363567245035A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCI1</accession>
    <accession>A0A3S7WTN3</accession>
    <name>E9BCI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Papain-like cysteine peptidase (DUF1796), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_151420</name>
        <name evidence="1" type="ORF">LdCL_150019500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859665.1">
        <property type="nucleotide sequence ID" value="XM_003859617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCI1"/>
    <dbReference type="GeneID" id="13393046"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1740"/>
    <dbReference type="OMA" id="PECVGPW"/>
    <dbReference type="OrthoDB" id="433668at2759"/>
    <dbReference type="PhylomeDB" id="E9BCI1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014903">
        <property type="entry name" value="DUF1796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08795">
        <property type="entry name" value="DUF1796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="405" mass="44988" checksum="E9036CD626EC3869" modified="2011-04-05" version="1">MFCGSRRVYRAALFHGASLPRKYISLGGWCGPALMLGKLGLRTEAYPFDFSRVTLDGLMHFIRNGFAEGFYPPGPPPYRPECVGPWVLFRGQHTAFAHFDLNDPHVQAHFQVKMRRFDAVLDSPERPVTFFRTVTARYPQEELALALDLEEAVARRNPSLDFRIVFMVHDQGLRANAVQLAPLSPRVTLWTLQYRGLPGDTLFDRTHTAYRTVMMHSVAESNWPAVNVGAATPPPATVASAEARDFESGALRCDGAIRTDDVPLADLTVARFPWRGHDNLALINGVASVGGTCAGIGSTKMLEDTSAAPQVEERVRRKCRYCGDATYHAAGRPFRTERPFTDEEDQLVLIHLYQILTGGDKVAAVEKLAHEMQRGTYEVICRIQHLTNSSTKLMDSIDPASPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDV8</accession>
    <accession>A0A3Q8IEB7</accession>
    <name>E9BDV8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_081680</name>
        <name evidence="13" type="ORF">LDBPK_181280</name>
        <name evidence="11" type="ORF">LdCL_180018100</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860142.1">
        <property type="nucleotide sequence ID" value="XM_003860094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024329231.1">
        <property type="nucleotide sequence ID" value="XM_024473460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDV8"/>
    <dbReference type="GeneID" id="13393444"/>
    <dbReference type="KEGG" id="ldo:LDBPK_081680"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1620"/>
    <dbReference type="OMA" id="VWSNIIC"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000139">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="212"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="308" mass="33259" checksum="F9A7918703D0CED4" modified="2011-04-05" version="1">MSPQTASAPKAPAPPLPLWQTLCVSGFAGMFGWCFTHPFEMWKNTVMMAAPGTSQLDSLKATARKGFYTGLSSGLMRQLIYATARLGFYPSFRDGILEGEVALGLKKSADPAGATPFDRALAGASAGVFASFLSSPVEVCLVLQTTSKGKERLSMLQACDGVLKSRGVTGLWSGFGALASRAALVGVSQVAVHDQVLTMLRKRNVKRADPLGDNVVVNIASVITALFYSAVTMPVEVARVRMSAEAKLSAGAERRYHNVVQCIGRIFKEEGLLAMYGAFAPYFCRCAIHTMLCFFVIEYGTRTMRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEI8</accession>
    <accession>A0A3S7WVY7</accession>
    <name>E9BEI8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_200410</name>
        <name evidence="2" type="ORF">LdCL_200008800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860381.1">
        <property type="nucleotide sequence ID" value="XM_003860333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEI8"/>
    <dbReference type="GeneID" id="13386171"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0470"/>
    <dbReference type="OMA" id="CPRRYFE"/>
    <dbReference type="OrthoDB" id="266634at2759"/>
    <dbReference type="PhylomeDB" id="E9BEI8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="464" mass="50088" checksum="146251D799869E64" modified="2011-04-05" version="1">MVLAALQWCRARSRRTEDAARGEEIEESIRLVTTRLYRIQELWQAHQLRAVSQQHDSCTETLQHGPMSVKMQESRELSHQQLQVHISSCNASDENAEVLLTPKTAAPSSFHLHHCRPPPPPPPIYQQHLQNASVTSSYQPGIAGGSDLLAKLKPDSLMSLSSARGLKATVPLSPLIRSTGIIPSLRSAASTRVFAGISNAAALRRSLRAPQLDMEPPAFPLLPPPTQHPSSSSSTLTTWSEFEESPFYQVISTFQFPVDLSGEPSGGTDESVLETSSVETLVVHYRGGGGAQSPRGTADDCAEEGMAAMARHTGVAAAYRHVDLHIHLEVDEPDETPMPQRCRYGCAGEKHRGLLPSPTPHSCPRRYFEGDAAFMSNSPAVEDSRVNLAAGNNSAALPATRTERRAHETVAAAVAEGGDSSLDASVFADDAELQGRFTPSRLKSARESGGSRLLLVSLHPTALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEQ8</accession>
    <accession>A0A3S7WW27</accession>
    <name>E9BEQ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_201090</name>
        <name evidence="2" type="ORF">LdCL_200015600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860450.1">
        <property type="nucleotide sequence ID" value="XM_003860402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEQ8"/>
    <dbReference type="GeneID" id="13386236"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1350"/>
    <dbReference type="OMA" id="GRQSKMP"/>
    <dbReference type="OrthoDB" id="267978at2759"/>
    <dbReference type="PhylomeDB" id="E9BEQ8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30129" checksum="36C4553233D91909" modified="2011-04-05" version="1">MNNYAAGEETSSCQPSFSPSYLLTDAMPVRSRFMNPVDFLSSSEPLMLTPEEKAAEKAEKARMVALQEDARALAALFARELAKRKAKAITAGVIKARRPAAAAAVPASSKPARLGGQQQSPLFPPTHSIKLAPVAPKPQRSHHKASVKSEKLRVKALKRGRKLKTSRRPRALAAQRSSPISRKRGRQSKMPAATSVSMHQPHPPLQRRPSRPPLRLAAAARMRVAAASHKAGRRAARAPKSFVMRPLSKSTVKAWRLAQQQKRVIGKARHGKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFV7</accession>
    <accession>A0A3Q8IC90</accession>
    <name>E9BFV7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_220900</name>
        <name evidence="2" type="ORF">LdCL_220016400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860838.1">
        <property type="nucleotide sequence ID" value="XM_003860790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFV7"/>
    <dbReference type="GeneID" id="13389561"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1410"/>
    <dbReference type="OMA" id="KWCGYSS"/>
    <dbReference type="OrthoDB" id="239465at2759"/>
    <dbReference type="PhylomeDB" id="E9BFV7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27388" checksum="88AB6F848BF55CDE" modified="2011-04-05" version="1">MGWFRSSASGAAGTATAEAPAAATEHGAQYRQPQPEANSPAPLTEAEQLDLLVAGARLDGTEAQDTDRFLGSNRRHTYADGLLSCAAYTFSGLQHIQGQSSALTLLTMWTVGTTFLVDVAERKYLQESLQSTLCTTQTRSVAEKPLLLDQPPHNATPASTPGKAAVAPAMPTAYDSLSSAIKKSAPQDKEKLAEQQRKVFLTQAVASWLWMLASFQQFKVHKRLKWCGYSSWMGLGCAGYYTTRHLYNLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGY6</accession>
    <accession>A0A3Q8IBX0</accession>
    <name>E9BGY6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps72/YL1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_241230</name>
        <name evidence="3" type="ORF">LdCL_240017400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861214.1">
        <property type="nucleotide sequence ID" value="XM_003861166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGY6"/>
    <dbReference type="SMR" id="E9BGY6"/>
    <dbReference type="GeneID" id="13391136"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1450"/>
    <dbReference type="OMA" id="QRICYTS"/>
    <dbReference type="OrthoDB" id="273846at2759"/>
    <dbReference type="PhylomeDB" id="E9BGY6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="324" mass="35869" checksum="0C3776E702BEE527" modified="2011-04-05" version="1">MEWADDVVNRPRRANAGNRLQELLANGLDEEEEKALQALSDASSDTSFTLGSDEETVDEVESDFDAEEVGGTLEGEDVETEASVRRAERQERQLERRKKLQRSQNFSKVAARDRAQRLESTKRQEKRQRGTDDAERVPRQRQPRKDEAVAENDDEDGEEEDDEDGSDDVIDLRQRVRHRPVPTIPCSQRLAEAYARAAALRAAQAAAEAPRDGNAEGASFSGGAGVVYTHRGLNMLKARQRARRPQHSSNSTMPRSAWEAREALSAPVEGTISEPIPVCVSPRIALYEGIPQRVGYSSGASVLQRFRVPTVVSFSAALPPVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGZ8</accession>
    <accession>A0A3S7WYD9</accession>
    <name>E9BGZ8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_241350</name>
        <name evidence="5" type="ORF">LdCL_240018600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861226.1">
        <property type="nucleotide sequence ID" value="XM_003861178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGZ8"/>
    <dbReference type="SMR" id="E9BGZ8"/>
    <dbReference type="GeneID" id="13391148"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1630"/>
    <dbReference type="OMA" id="PKACELI"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="PhylomeDB" id="E9BGZ8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000083">
        <property type="entry name" value="Putative cyclophilin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26618" checksum="F00089D0B116F67B" modified="2011-04-05" version="1">MIALAFPRPLTTSFFLPVFVMDHRYSAFPESEERQLVVLPEPQLTMPPRKAITKVKLHSAESVDTDLQNCLLRIDKGTDVYGMLVIELDSGRSPKACELVAQNIPASNTTDKSRGKQGVYKNCRFTRLTKEGIQTGEVVPAAKPVPAAELEGEIGRVPHCYGAVSLCRSSTSFDGSQFFICLTSDSVELDHLNKKHVCFGRVVEGHDVLAALQSDLAEYSGDMGLVRKDCPYVMAELSYASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIS6</accession>
    <accession>A0A3S7X096</accession>
    <name>E9BIS6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_262650</name>
        <name evidence="1" type="ORF">LdCL_260032400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861849.1">
        <property type="nucleotide sequence ID" value="XM_003861801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIS6"/>
    <dbReference type="GeneID" id="13389097"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3440"/>
    <dbReference type="OMA" id="MCQQASL"/>
    <dbReference type="OrthoDB" id="261014at2759"/>
    <dbReference type="PhylomeDB" id="E9BIS6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="277" mass="30217" checksum="5522534A686DFF3F" modified="2011-04-05" version="1">MASTLEAEIAFLLSVAAHLGHSSEHIGENEDDASGAPPVSSLTTSEREVLAELLLLEKKEGDYVFATRADTAAAGGVEALLAESPLTAMYRGEAVSPYTRFILSFYSSTLYAQVPTKVNTIAIRLFQRFLCGCRGDALQQVHHGFGRRSMEVVLRECVNLAGNLSSTLQIAAPSEMTGLVIAELNYDVQEVSPLDYLDVILPHISYLSQMCQQASLLLLAHEEMVRQPSSLVALFTIVFTIRNMGAGDDAVALLLSSWPECRQAAFYRMNAFLNCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJE9</accession>
    <accession>A0A3S7X108</accession>
    <name>E9BJE9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_272190</name>
        <name evidence="2" type="ORF">LdCL_270029300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862070.1">
        <property type="nucleotide sequence ID" value="XM_003862022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJE9"/>
    <dbReference type="GeneID" id="13386805"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3330"/>
    <dbReference type="OMA" id="PAWNQRQ"/>
    <dbReference type="OrthoDB" id="265985at2759"/>
    <dbReference type="PhylomeDB" id="E9BJE9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="657" mass="69370" checksum="0FCE89C0A133CF75" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKN7</accession>
    <accession>A0A3Q8IR74</accession>
    <name>E9BKN7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_290900</name>
        <name evidence="2" type="ORF">LdCL_290013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862508.1">
        <property type="nucleotide sequence ID" value="XM_003862460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKN7"/>
    <dbReference type="GeneID" id="13387249"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1220"/>
    <dbReference type="OMA" id="QQLWCAQ"/>
    <dbReference type="OrthoDB" id="265002at2759"/>
    <dbReference type="PhylomeDB" id="E9BKN7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="459" mass="49309" checksum="53B78EC9668CC239" modified="2011-04-05" version="1">MQHDMENSMENEATLPLREVQAAVASSSPGVGKQYSDTSTIRCRGRCYTVPETSLSMPSSTQSVDALQTKPTTSPSPTEGETVCDLVRYHAELTLGLQQSMLWFISQLDSSLLTSSQEDGGVCGVLTHPRAAQLQWMFLDAVVQFVTHLQQRWSEGTASTGSVEAVGEASVVLNRLAQAAQELRHPSHSRQLQVFELSERGIARRSPPPFASWRSDSSAMRAFGGTSPLLCNTSPRAATSAPNPIDECLGVAGADYSAKLIAQQLWCAQQLLSQRFPGYAATWEVLEGARFFVESARSPTPTVPRSDSSQQVATQVAAPSPVTVVDLNCTQSSSHGGCTPPPCVVETQRKCERPHDLQRELRLPSRGLTFIEEQAADVTDDASTAMKGATASRNGFLTESPGAPPTPPARPLLLPVARCALWDNFLASKSFPPSALLLAIQNLAAGTISLQPEDIVQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKW5</accession>
    <accession>A0A3Q8IEG1</accession>
    <name>E9BKW5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase activator protein, putative</fullName>
            <ecNumber evidence="3">3.6.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_291670</name>
        <name evidence="3" type="ORF">LdCL_290022300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862586.1">
        <property type="nucleotide sequence ID" value="XM_003862538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKW5"/>
    <dbReference type="GeneID" id="13387322"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2420"/>
    <dbReference type="OMA" id="ENEYFCA"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="PhylomeDB" id="E9BKW5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000121">
        <property type="entry name" value="Putative GTPase activator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="224"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="529" mass="57687" checksum="0B7870F445B0B2A3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMX4</accession>
    <accession>A0A3Q8IEY9</accession>
    <name>E9BMX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_312020</name>
        <name evidence="1" type="ORF">LdCL_310028000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863291.1">
        <property type="nucleotide sequence ID" value="XM_003863243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMX4"/>
    <dbReference type="GeneID" id="13389465"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3640"/>
    <dbReference type="OMA" id="EMQANLH"/>
    <dbReference type="OrthoDB" id="10468487at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="70" mass="8023" checksum="4102CA0A9DC3AC6D" modified="2011-04-05" version="1">MELYKRTLDGLMAFTLTQLEGAAVEVKEVKEKRSKEFAAAWKRLEEMQANLHRRAASWDASCGRCLSAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNF7</accession>
    <accession>A0A3S7X585</accession>
    <name>E9BNF7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_320530</name>
        <name evidence="1" type="ORF">LdCL_320010800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863471.1">
        <property type="nucleotide sequence ID" value="XM_003863423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNF7"/>
    <dbReference type="GeneID" id="13390283"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0660"/>
    <dbReference type="OMA" id="QIVYHRI"/>
    <dbReference type="OrthoDB" id="264265at2759"/>
    <dbReference type="PhylomeDB" id="E9BNF7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="260" mass="29436" checksum="E628D0614AC0F948" modified="2011-04-05" version="1">MPAKVANSKTQTLRDGRKLGVEKLVELVFIGRPRTLSFSHRSLGSLRHPYSSLVCETSAARASTQDKITYLLEAFSEAKAEKKAWMRVERIFDSMLGDALMEKMKLGLLLSSELLQRFEVLWIRLGGASGDIISEDTYKQFHQQLYFTLFGIEQMTLLPATMQFILEDYQYDSQGKSGIEFGSFAHSMLELADNWAGSREVADYVAFMDKIVECYPDSTVQPRKAHAPDELTLSKEAFFRGGVVVPRVEGEQTVYHRITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BP43</accession>
    <accession>A0A3S7X5V5</accession>
    <name>E9BP43_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_322920</name>
        <name evidence="3" type="ORF">LdCL_320035200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863705.1">
        <property type="nucleotide sequence ID" value="XM_003863657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BP43"/>
    <dbReference type="GeneID" id="13391230"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3700"/>
    <dbReference type="OMA" id="WAFTCYA"/>
    <dbReference type="OrthoDB" id="272520at2759"/>
    <dbReference type="PhylomeDB" id="E9BP43"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1093" mass="115248" checksum="526955A44698FA7A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQP9</accession>
    <accession>A0A3Q8IE77</accession>
    <name>E9BQP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_340970</name>
        <name evidence="2" type="ORF">LdCL_340015200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864260.1">
        <property type="nucleotide sequence ID" value="XM_003864212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQP9"/>
    <dbReference type="GeneID" id="13392669"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1540"/>
    <dbReference type="OMA" id="FDGRTDC"/>
    <dbReference type="OrthoDB" id="273404at2759"/>
    <dbReference type="PhylomeDB" id="E9BQP9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="691" mass="74731" checksum="66A248BBD2AD8FC2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRY5</accession>
    <accession>A0A3S5H7Y7</accession>
    <name>E9BRY5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_351090</name>
        <name evidence="2" type="ORF">LdCL_350015700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864694.1">
        <property type="nucleotide sequence ID" value="XM_003864646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRY5"/>
    <dbReference type="GeneID" id="13387574"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1400"/>
    <dbReference type="OMA" id="MRRYAQW"/>
    <dbReference type="OrthoDB" id="266813at2759"/>
    <dbReference type="PhylomeDB" id="E9BRY5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="507" mass="55676" checksum="9C0E99F11C210A01" modified="2011-04-05" version="1">MRAKNMTRPAYLIDHVIHAVPVAIVHYCCELKRQLATLPLLRFSDLLPSPGTAKTRGGTCKSPAGAAAAAWLPTEGWFEKLPAPYVAHLLLMRWMLAATEAYIEKLFFDQSLVVRQLRSKRIRRRLLGWGLRLVSHTVFDPFLLSIVVPLLLSWGATPNAGDASSPLPSPPPRVLFTVAGAVRGLVISAAGVTIQQLLMPLASQLVDRAVLTVFESVEYLIMRRYAQWSDEDEDNDYNEDDEDDDDRASLASGASEGARSQQSVNMSIATTAPSGGGAGGTATLSAEKRVEHVQRRLRRERRERRKRRERRQAEREHAMRLAILRAIVYRVVASLVAQSLIDHPLSVLVELLRGRATLHLTGLLRPYAVMTDASDGLSWANLWRYALQLADTTVTVSDATNGGDADEEGVPPMVTVLRRAGRMITQEVVVLSSSVLTASGQTAAIAAVQQRAAQTVAQGGIPSAADSAHFMARTLSSLSPFYYGIQFTVIDKVLSFYMAVWTRLTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSD3</accession>
    <accession>A0A3Q8IIC8</accession>
    <name>E9BSD3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_352630</name>
        <name evidence="9" type="ORF">LdCL_350031200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864842.1">
        <property type="nucleotide sequence ID" value="XM_003864794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSD3"/>
    <dbReference type="GeneID" id="13387720"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3390"/>
    <dbReference type="OMA" id="LRIVWCC"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="PhylomeDB" id="E9BSD3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF478">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="107"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="279" mass="30936" checksum="28F26339853C1716" modified="2011-04-05" version="1">MPLPPGTTKRALGRLRIVWCCVVTAESWHSLFVGLPILFFTTLFVTVVVPRGEWFTYVFTALFTTISVTCLTLSVTLDPGVIPPAPQSQQPTQSTTVMVGGQPVLCKVCTTCHIIRPPRSTHCRFCDVCVEEFDHHCGIIGSCVGKRTFRFFGGFFVITSFLVLYILIRSFIILVSTDFKPANERPHLIWLAVSCTLCIVAAIIGAILVMPCAGRYIMLSASNSTVKETMRTQRQQTKSGEQPPGVVPVAETKSGNYCANLRRLFSPIGRSRIPYDYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUD9</accession>
    <accession>A0A3S7XBE1</accession>
    <name>E9BUD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_364310</name>
        <name evidence="2" type="ORF">LdCL_360050200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865545.1">
        <property type="nucleotide sequence ID" value="XM_003865497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUD9"/>
    <dbReference type="GeneID" id="13388431"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360050200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5830"/>
    <dbReference type="OMA" id="QYGLLCA"/>
    <dbReference type="OrthoDB" id="273516at2759"/>
    <dbReference type="PhylomeDB" id="E9BUD9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1021" mass="108422" checksum="4D89FF7B0E98697F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8P8</accession>
    <name>A0A3Q8I8P8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LdCL_100011200</name>
        <name evidence="21" type="ORF">LdCL_100011500</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8P8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011500"/>
    <dbReference type="OrthoDB" id="264225at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000003">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU76666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="599" mass="63810" checksum="1E5E44A347074E4E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I989</accession>
    <name>A0A3Q8I989_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_120011800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I989"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0940"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000127">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="961" mass="109603" checksum="5A139D3B351E4FEF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAB4</accession>
    <name>A0A3Q8IAB4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_36600</name>
        <name evidence="9" type="ORF">LdCL_160012800</name>
        <name evidence="10" type="ORF">LDHU3_16.0910</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAB4"/>
    <dbReference type="SMR" id="A0A3Q8IAB4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0910"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5428938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP40969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="330" mass="36972" checksum="1BF036B4E266DF33" modified="2019-04-10" version="1">MPNRLEQLREMTTVVADTANFSLMEKFRPEDATTNPSLVLAGSQMTEYANLLTEAIDYARANISRHSDHYTSDDNDENLVALALDKLTVSFGIQILKVVPGRVSTEVDAKLSFNEQKMIDKARLLIRMYEEAGISRNRIYIKLASTWEGIQAARTLEKEGICCNLTLLFSFAQAVACAQANVSLISPFVGRILDWYRKAEPAKADCFVGAADPGVVSVTKIYNYYKKHGYKTIVMGASFRNVEEILELAGCDKLTISPSLLEELAASEGNVVRKLHPDKVTEVEKLPELSREDFLFMHNEDPMAVEKLSEGIRNFHKDTVKLTNAIREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAD6</accession>
    <accession>E9BFB1</accession>
    <name>A0A3Q8IAD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epsilon tubulin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Tubulin/FtsZ family, GTPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_34275</name>
        <name evidence="9" type="ORF">LDBPK_211250</name>
        <name evidence="8" type="ORF">LdCL_210017600</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860642.1">
        <property type="nucleotide sequence ID" value="XM_003860594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAD6"/>
    <dbReference type="SMR" id="A0A3Q8IAD6"/>
    <dbReference type="GeneID" id="13386501"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1480"/>
    <dbReference type="OMA" id="KRAHLHH"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02190">
        <property type="entry name" value="epsilon_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000017">
        <property type="entry name" value="Tubulin epsilon chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="39"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="265"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP49347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="470" mass="51829" checksum="9AD380EFF7734B65" modified="2019-04-10" version="1">MPREIVTVQVGQCGNQLGQRWFDVMLQEHKAYSHFPEARDAVFLEDMNHPGRLKARCVAVDMEQGVLHAMLRGPLKDIFDANFFVSDVSGAGNNWAVGHMEYGDRYIDAIAESVRNQVEQCNCIQSFFLMHSLSGGTGSGLGTRVLGMLEDEFPHVFRICPVVMPSEVDDVVTAPYNSCFSLKELIEHADCVLPLDNDALARMADRALSSRPKGRGVMACSVPQPQAFSAAKPTDTKGLPYDSMNGLVAQLLSNLTCAMRFPGPLNMDINEITTNLVPFPRLHFLTAAIAPLSVSSKHAAVGPRTVDAMIAACLDPGHQFVDVRHGQGSAVTREAGKTLATSLIARGPQTTVGDLTRGVGRLREQMEMPYWNEDGFKTALCGVSPLGHKDSMLLLANNCSIRGKVESMLSKYERLYSVRSHVHHYDQYLSDAYFVHTVETLRTLVDDYAYLDTAAPPKDLPRSMKDLIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAF1</accession>
    <accession>E9BEY7</accession>
    <name>A0A3Q8IAF1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 16">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CGC21_29725</name>
        <name evidence="20" type="ORF">LDBPK_200110</name>
        <name evidence="19" type="ORF">LdCL_200006000</name>
    </gene>
    <organism evidence="19 23">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19 23" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 23">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="24" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 17">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860352.1">
        <property type="nucleotide sequence ID" value="XM_003860304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAF1"/>
    <dbReference type="SMR" id="A0A3Q8IAF1"/>
    <dbReference type="GeneID" id="13386313"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0120"/>
    <dbReference type="OMA" id="SCKFAFG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000007">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000011">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027250">
        <property type="entry name" value="Pgk_euglenozoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500126">
        <property type="entry name" value="Pgk_euglenozoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU78291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBZ33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP49979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="479" mass="51328" checksum="1C72757864A7CB1D" modified="2019-04-10" version="1">MSLVLKKSIDDATFRDKKVLIRVDFNVPVKNGKITNDFRIRSALPTIQKVLKEGGSCILMSHLGRPKGARMSDPRPEKGVRGYEEAASLRPVAARIAELLGQKVEFAPDCLDAAVYASKLKSGDVLLLENVRFYAEEGSKKEEERDAMAKVLASYADLYVSDAFGTAHRDSATMTGIPKVLGAGYAGYLMEKEINYFSRVLNNPPRPLVAIVGGAKVSDKIELLDNMLGRINYLVIGGAMAYTFQKAQGRKIGISMCEEDKLDLAKSLLKKAQERGVQVFLPVDHVCNKEFKAADSPLVTENVDVPDGYMALDIGPKTIHLYEEVIGRCKSAIWNGPMGVFEMPCYSKGTFAVAKAMGTGTQKSGLLSIIGGGDSASAAELSGEAKNMSHVSTGGGASLELLEGKTLPGVAILTDKNVKERGSSCKFAFGGGAPGREVCPRGSGHIFGGASIVTEIVKLVGALLIGIFIGRRMSTKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAQ3</accession>
    <accession>E9BDB8</accession>
    <name>A0A3Q8IAQ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">META domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_4105</name>
        <name evidence="4" type="ORF">LDBPK_170970</name>
        <name evidence="3" type="ORF">LdCL_170015700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859951.1">
        <property type="nucleotide sequence ID" value="XM_003859903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAQ3"/>
    <dbReference type="GeneID" id="13393388"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1390"/>
    <dbReference type="OMA" id="HEKKWAF"/>
    <dbReference type="OrthoDB" id="269925at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000055">
        <property type="entry name" value="META domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF8">
        <property type="entry name" value="CYSTEINE PEPTIDASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="225"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="2">
        <location>
            <begin position="340"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="444" mass="48383" checksum="8E604693C4734A3E" modified="2019-04-10" version="1">MTTADDVCGAYTLSHCDGRVAPTKAILTIHRCGETLTAHATVANDLRGTVQYENCHIVGSLHSTGNEASPAEESVEQALSKGFADGFNVVVEINQVLLKNANSSFVFARLSKLSDLNGEHAIIAINDQPPNQEMTMTFTPDGNGGSFVTANIANSLRGNCQIDAGLLRGDLATTQSEADESLMQVEKLISEGFHQGFHVCTNESGILLQSSEANIQLCRIVSHNDLEGEYMLKSFNGAAVPTRNQPSIVFKPVNTNEVEISIVVTNRIRGTAALNQNVLSSEEPLMSTRMMGTEEESQLENAFNVGFQYGLETISHGNELTLKNQDCKFVLVKAAAPAAQHGGPTYKGTYCNKCFKTEGNGLLFRIVNEHEKKWAFYNDTEDLRIRVRATFGARSKIEALGNANMCKDDDGRYVVEVTVDPQATEMFIQGDVNGFRVLYDAQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB82</accession>
    <name>A0A3Q8IB82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_240007900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB82"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0340"/>
    <dbReference type="OrthoDB" id="271385at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="319" mass="34895" checksum="B70AE331A48946BB" modified="2019-04-10" version="1">MKPYVWPTSDEAPPPSGRRTFPCQFKVNHGTLNLFSPAAPEPQQCSTRAVAGPFSITGQRGILHQRNHNRESTATREFPVNGLRRVSAPQRSETPHGIRHIRGAAGAQQHVQVVNITDAYKDPMQMGPRRTGVKCLPQKSESNDVSAALAFAGSRQQLSARVLAAPVGKPSRPSLYTIDYSDKERFAQAVRDHAQKRARGVAEFYVQLVRDTVGGVTSSTPKPAIVPWSLDQEPTRRVLTLERCRDQLVALTSMPISLSDLAQLLWGSSDGEAANSDGLTSDFDKDASLPLSCRPVPFRDFAAAFGQNSSDVRLARMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBR9</accession>
    <accession>E9BGN0</accession>
    <name>A0A3Q8IBR9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase 4 regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_15775</name>
        <name evidence="4" type="ORF">LDBPK_240180</name>
        <name evidence="3" type="ORF">LdCL_240006700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861108.1">
        <property type="nucleotide sequence ID" value="XM_003861060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBR9"/>
    <dbReference type="GeneID" id="13390558"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0210"/>
    <dbReference type="OMA" id="CLIDLVE"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000909">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039918">
        <property type="entry name" value="PPP4R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="90823" checksum="F013DD4E8F5D3790" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBY8</accession>
    <accession>E9BGN3</accession>
    <name>A0A3Q8IBY8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_15790</name>
        <name evidence="3" type="ORF">LDBPK_240210</name>
        <name evidence="2" type="ORF">LdCL_240007000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861111.1">
        <property type="nucleotide sequence ID" value="XM_003861063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBY8"/>
    <dbReference type="GeneID" id="13390561"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0250"/>
    <dbReference type="OMA" id="REAGCMY"/>
    <dbReference type="OrthoDB" id="270822at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37760" checksum="AFEE0770CA3D8EA4" modified="2019-04-10" version="1">MRVTVKWFLTGRYSVIEDSDAILSPDTTIAELKGLIQIRFGFSSNELLLVLDHLLENTVTLRSLSIMGQPCDPIMTAHVVRESVLEMSNLKHQDDTSKDDDLHEFSHADFILAMKMLGKDVPVPDDRLVAMRLNAPRQRPVFLDARREDEDDAAGPERVPQPPPGMPGLAGCEVPTYNPKKTEVYQIVSRVQYGPRKEGVDTEFAIQYPGVNEPFPFWDMRTPDPFVRIDGQCAPGEVCLELFYFGDFDAVKDQPGFLLVVQQSLQSKAGVRLRTPLPLREAGCMYPLIAVPIVLHEMDAMELGDIFFEDFGRVESARPLKGNNDGAEVAGSGGLGCAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICY0</accession>
    <name>A0A3Q8ICY0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_260018100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICY0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1550"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF9">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="523"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="977" mass="107478" checksum="AD4100193C586C8A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID22</accession>
    <accession>E9BKE4</accession>
    <name>A0A3Q8ID22_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_22020</name>
        <name evidence="3" type="ORF">LDBPK_281060</name>
        <name evidence="2" type="ORF">LdCL_280015200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862205.1">
        <property type="nucleotide sequence ID" value="XM_003862157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID22"/>
    <dbReference type="GeneID" id="13386941"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1270"/>
    <dbReference type="OMA" id="AKSKSHM"/>
    <dbReference type="OrthoDB" id="273307at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17575" checksum="31BAF12697C85197" modified="2019-04-10" version="1">MSANVNFSAGSRTTKTAPSGPAVSPSAKNKSHMILPYEVLFNLVGRRVTVLLTKGSQELEGTLQSVDSDKGDMLLSDVVRYTWAPSRSSDEEETAAAAAGNGQCTLGTVSEEEGCSKCFGGGQRRELSRCSQAMLNSAFVALVTPTLFIPEERHSALRAHEHTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID51</accession>
    <name>A0A3Q8ID51_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC21_4795</name>
        <name evidence="14" type="ORF">LdCL_140013200</name>
        <name evidence="15" type="ORF">LdCL_140013300</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID51"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1020"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="397" mass="45692" checksum="EDE7FB30902BC1C4" modified="2019-04-10" version="1">METLRAAWDWINYRPRRFSAENGRNFLDSYPDYPAYATVLYLLAVFYLPDLLARRQISLPIKHIVAAWNLFLSVVSTYGVFCIYGHIRDVFSVRTFHNSVCELLATSGANDIITLRAIHVHAHQKMLIEQRHLPVKWVRSTPEVAKEITSLYDGSAGFSVAMFMYLKTPELLDTLFLVLQRKPVSFLHWYHHIVTAIYVWLSSYMPMPSGIVFCAMNYFVHSFMYFYYFLVMMGLRKSIRPFAPVITLLQVLQMFIGMYITVYTYFQYWLGPEYSNTLFFKLFEVVLSNAYHAYCNAKSVVTTGALASQVPAFDMSDRFWGCDSDPTCMRMGMLMYGSYCVLFAVLFKELYLDKRVHENSLVLARKEQQAREGKFKGEMNGNGVTTPAVAGAKPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDD3</accession>
    <name>A0A3Q8IDD3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport protein 88, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_270016600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDD3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1630"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001044">
        <property type="entry name" value="Intraflagellar transport protein IFT88, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001672">
        <property type="entry name" value="Intraflagellar transport protein IFT88, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001048">
        <property type="entry name" value="Putative intraflagellar transport protein IFT88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001309">
        <property type="entry name" value="Putative intraflagellar transport protein IFT88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="811" mass="91104" checksum="C044DC8168406C56" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDI7</accession>
    <name>A0A3Q8IDI7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_26100</name>
        <name evidence="5" type="ORF">CGC21_9215</name>
        <name evidence="3" type="ORF">LdCL_250030700</name>
        <name evidence="4" type="ORF">LDHU3_25.2980</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDI7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2980"/>
    <dbReference type="OrthoDB" id="267731at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="129" mass="13906" checksum="F9105740AE859087" modified="2019-04-10" version="1">MPPRRKNASRSKSRSASQSSGKSSPRPSGRAPAKSPSLPPPDPVAVQRLIDEAIARARERRASNDAAAPPTSVSASSHQPVSACFSKRLFSASASEKMTDMIGAFLVTCITVYFTWAGYAFYREMTINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE79</accession>
    <accession>E9BJ21</accession>
    <name>A0A3Q8IE79_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exocyst complex component Sec6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_30970</name>
        <name evidence="6" type="ORF">LDBPK_270870</name>
        <name evidence="5" type="ORF">LdCL_270015300</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861943.1">
        <property type="nucleotide sequence ID" value="XM_003861895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE79"/>
    <dbReference type="GeneID" id="13389204"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1460"/>
    <dbReference type="OMA" id="LWEEQIM"/>
    <dbReference type="OrthoDB" id="277975at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000010">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="882"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="105187" checksum="BB838C78D05A7B1B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK8</accession>
    <name>A0A3Q8IEK8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320046000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320046000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5130"/>
    <dbReference type="OrthoDB" id="264823at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31792" checksum="6527ED86C5B1D2F6" modified="2019-04-10" version="1">MRTTAGSGAGAFDAAHAIPTAVPLTVADIDALARRDGAVSSGAVISQQSTVASSRSVAELEAVVQSLQQENAELRERLERDRRQMLRSAMDVRDLHASQKQIRQRDLDRIEWLHCDNQRLRKMLEMQGSAHELANAVPPQPQAAAPPTAPPPSSEGLRSLPEMPVELNAMEEDMPALEAEVVRLRGALALKTQHLDDLQGHAERAEGYVQDLLRKLEHVQGIVREERDNCARRSEHLASAEQPLEDIVSVVSLRDYSSATQLTGPNSTTQSPFATVGRREHIKRAAAVHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEU7</accession>
    <accession>E9BRR9</accession>
    <name>A0A3Q8IEU7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable eukaryotic initiation factor 4A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CGC20_0765</name>
        <name evidence="26" type="ORF">CGC21_5790</name>
        <name evidence="25" type="ORF">LDBPK_350370</name>
        <name evidence="24" type="ORF">LdCL_350008700</name>
    </gene>
    <organism evidence="24 29">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="25 28" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 28">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="24 29" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 29">LdCL</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">FDAARGOS_360</strain>
            <strain evidence="26">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="30" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="31" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864630.1">
        <property type="nucleotide sequence ID" value="XM_003864582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEU7"/>
    <dbReference type="SMR" id="A0A3Q8IEU7"/>
    <dbReference type="GeneID" id="13387508"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0890"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 19 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="23">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="61"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="242"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="AYU82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CBZ37948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="TPP44325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="TPP46495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="405" mass="46379" checksum="D36F93C824F89EFE" modified="2019-04-10" version="1">MSDSNWKAQLNAPQKSTRKKTEDVESRRNVNFEEYALRRELQMGIFEKGFEKPSPVQEEAIPVALQGKDVLARAKNGTGKTASFVIPVLEKVDTRESYVQALLMVPTRELALQTAQVTKELGKHIPGLEVMVTTGGTTLRDDILRLTSKVHILVATPGRVLDLASKKAVDLSHCHILVLDEADKLLSQEFMEIIDDLYTYLPSQLQSMLFSATFPVTVKTFAERHLHNPYEINLMDELTLKGVTQYYAFVEERQKIHCLNTLFNKLQINQSIIFCNSVNRVELLAKKITQLGYSCYYIHARMQQQHRNRVFHDFREGHCRNLVCSDLITRGIDIQAVNVVINFDFPKYAETYLHRIGRSGRFGHLGVAINFVTYDDRYNVYRIEQELDTEIKPIPAEIDPELYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEW3</accession>
    <name>A0A3Q8IEW3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P1/s1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300020400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEW3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1980"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.575.10:FF:000003">
        <property type="entry name" value="Single strand-specific nuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018619343" evidence="8">
        <location>
            <begin position="29"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="316" mass="35101" checksum="9157CF97005BC96C" modified="2019-04-10" version="1">MPALVGLRLPLTVLCLLVLSSALCVTEALGWGCVGHMLLAEIARRQLDDKNKEKIDAMAEVFAQSGPFPSSPDMVQAACWADDVKRWRQYAMATWHFFAAPYNPENINITDAIATVNAVTVSRNMISALKNTKAPLYMLNFAWANLVHIFGDLHQPLHTISRYSSEYPHGDKGGNAVEVRAGRRKVKLHALWDNICTGTPPRYQRPLSYTDLFALAATADRLLETYKFPEALRTLVDIREVHEESHMFAVNTSYPGVTPGATLSEAYLARCKRVAEARLTLGGYRLGYLLNTLLSSIHVDEATLEAYRAARPKRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF83</accession>
    <accession>E9BQJ4</accession>
    <name>A0A3Q8IF83_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_25535</name>
        <name evidence="3" type="ORF">LDBPK_340400</name>
        <name evidence="2" type="ORF">LdCL_340009100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864205.1">
        <property type="nucleotide sequence ID" value="XM_003864157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF83"/>
    <dbReference type="GeneID" id="13392614"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0570"/>
    <dbReference type="OMA" id="WDGCSPR"/>
    <dbReference type="OrthoDB" id="271148at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599598" evidence="1">
        <location>
            <begin position="34"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="572" mass="61279" checksum="2C41AF08B0E8BDFB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFA7</accession>
    <name>A0A3Q8IFA7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320011800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFA7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0780"/>
    <dbReference type="OrthoDB" id="239776at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="810" mass="90818" checksum="342316868CD2D879" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFE1</accession>
    <name>A0A3Q8IFE1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S19-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">40S_ribosomal_protein_S19-like_protein/GeneDB:Lmj F.29.2860</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S19e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_24635</name>
        <name evidence="7" type="ORF">CGC21_28965</name>
        <name evidence="4" type="ORF">LdCL_290035800</name>
        <name evidence="5" type="ORF">LDHU3_29.4330</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5432014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFE1"/>
    <dbReference type="SMR" id="A0A3Q8IFE1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4330"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000593">
        <property type="entry name" value="40S ribosomal protein S19 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="161" mass="18104" checksum="93C202F64528AD54" modified="2019-04-10" version="1">MTAPRNKIHRIGKRKGATLKDVSAWRWIKTAARHFKQEGKIFVPNCTEIMKSSHGRERAPQNPDWYYIRCAAVLRAIYLRPGVGYGGLSKRFGNKKNYGSRPEHTVTSSTGPLHWACKSLTKLGLVEPGAQAGQRLTRKGHKFADSLAFQVQIRKFGQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFI6</accession>
    <name>A0A3Q8IFI6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L13, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_290031800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFI6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3830"/>
    <dbReference type="OrthoDB" id="277928at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24779" checksum="6A9C4AF48CACB1BB" modified="2019-04-10" version="1">MPKGNNAIPHVHQKKHWNPCSSQKGNVKVFLNQPAQKHRRRRLRLLKAKKVFPRPLKALRPQVNCPTVRHNMKRRLGRGFSPAELKAAGLNPQYAATIGIRMDSRRKNKSEEGMNVNVQRLKTYMSKLVLFPMNHKKVQKGEASEEEVKAATQDRSRFGDAAVGAVVYPSAETPRAVSAEEKSMCVYAFLKKNHSAVRFFGARSARAARKEAAKEEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG78</accession>
    <accession>E9BS64</accession>
    <name>A0A3Q8IG78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_6475</name>
        <name evidence="3" type="ORF">LDBPK_351910</name>
        <name evidence="2" type="ORF">LdCL_350024300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864773.1">
        <property type="nucleotide sequence ID" value="XM_003864725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG78"/>
    <dbReference type="GeneID" id="13387652"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2510"/>
    <dbReference type="OMA" id="AEMHPIE"/>
    <dbReference type="OrthoDB" id="272706at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="326" mass="35690" checksum="0623E31FCE51C5F7" modified="2019-04-10" version="1">MLDPQAADLVDAVARLCVLRTEDYTLLRTVYRRAREHAHLQQQQETTPNPLQSTPESVSDAPDAKGCEGDASGAGNEAYIRYLTEEVRVREQRRGTEEGEWLGAVQQWAARFQARQVVATQDKARSAAPDGSASLAVPAIRWFWEQGREGAFQRVYAAVLQQAYELDRTDLVNTPFAYIDKSKCLYDHAEAAAAAVASAAMPSSQVECVHALFFPSSRAAEPSTSPSRILAEMHPIEADDASAVNEGGRSRLQASRHVWLVLFFLWCHIVAASMTTSAGAAAAAREVGAEPLFYESALLGPARDFLTSQSQQLQSLLTKLETTTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG81</accession>
    <name>A0A3Q8IG81_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division cycle protein 20, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_240023500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG81"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2200"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="411"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="836" mass="89824" checksum="733BCB385588DA68" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGU9</accession>
    <name>A0A3Q8IGU9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_330020700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGU9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2130"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="7">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20634" checksum="936713324DFC8FCA" modified="2019-04-10" version="1">MRSLTDDETKKLFDKLAQYIGVNTTHLLERKGEEEHVFRLHKNRIWYMPLRLAKLASCVSKTNLMGIGVLFAKVTHNGNVRIQVTALEYIAQYSLFKIWVKPNQEQKFLYGGNVSRAGLGRITESTPKYQKVAVFSMGDIPLGFGVAAQSTLECRKCEMNSQVLFHEADVGEYLRDEARMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH82</accession>
    <accession>E9BKR9</accession>
    <name>A0A3Q8IH82_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-disulfide reductase</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_25510</name>
        <name evidence="15" type="ORF">CGC21_28130</name>
        <name evidence="13" type="ORF">LDBPK_291230</name>
        <name evidence="11" type="ORF">LdCL_290017400</name>
        <name evidence="12" type="ORF">LDHU3_29.1700</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleoredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862540.1">
        <property type="nucleotide sequence ID" value="XM_003862492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH82"/>
    <dbReference type="SMR" id="A0A3Q8IH82"/>
    <dbReference type="GeneID" id="13387278"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1700"/>
    <dbReference type="OMA" id="EDSENMF"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052259">
        <property type="entry name" value="Nucleoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13871:SF96">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5431832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP50789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="275" mass="30415" checksum="4E60B9C7741A4EE8" modified="2019-04-10" version="1">MPLRHKGGPFLSQFPDLKVLRQDGTTVAASEAFKGKKYVLIYFSAHWCPPCQRFTPLLADFYDAHKDRYGFEVLFVSSDREEGRMMDFFQNRSSNYVRRPPAAASSSPPPVASSEALDESCPLSCDITHLLGNQTGAATVGGVGLSEGQQPQVPSSTAAAGGAPTAAGIAQSPRIPKASGHGNWLALPFKEHEVARFLSRAYSVVSIPKVVVVAVDTNCMVTREGKTMVMKDPDAVRFPWRFAEGDMRNRTEGWRESFVLLLLILCGIYYYFWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIG0</accession>
    <accession>E9BML8</accession>
    <name>A0A3Q8IIG0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_11840</name>
        <name evidence="3" type="ORF">LDBPK_310940</name>
        <name evidence="2" type="ORF">LdCL_310015400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863185.1">
        <property type="nucleotide sequence ID" value="XM_003863137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIG0"/>
    <dbReference type="GeneID" id="13385905"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1490"/>
    <dbReference type="OMA" id="TISHAQM"/>
    <dbReference type="OrthoDB" id="10436215at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744:SF1">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="119" mass="12944" checksum="C86AFC94E8A1BEE8" modified="2019-04-10" version="1">MGGLLEKSENRQSRNASKRLRSSSVPRGNDSNDGEPSSSAERLVAPPAGLLTSTVRRYLCLPTTHSRSSKGEKATSLAAQFYLMTVSQAQIPLLCLTLWKEAKLCDGGGFIQRAKVCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIP7</accession>
    <name>A0A3Q8IIP7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310030400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIP7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3960"/>
    <dbReference type="OrthoDB" id="266248at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="903" mass="96276" checksum="4641B3BD5F387166" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIT4</accession>
    <name>A0A3Q8IIT4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_310035600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIT4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310035600"/>
    <dbReference type="OrthoDB" id="268022at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21203" checksum="BCDA8179327B8C02" modified="2019-04-10" version="1">MLRDMLISEITVRVFDGLRESRSLARLGMRYGDAPLLKARSLVSSLTVLHAFSTTLTSVVALQHCTALEVADVSACAPLADLGTLDLAPCLREVDAAGSGVLHVSGLSRSCSLERFLLAQCVHLDEVGPLGQCVDLRELRPHWRWCSAVGRIGSRPLFESPRHQFLPPAAEFHIVAGSSAATLFVHKWLHSGPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIW3</accession>
    <name>A0A3Q8IIW3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diacylglycerol kinase</fullName>
            <shortName evidence="9">DAG kinase</shortName>
            <ecNumber evidence="9">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_350059200</name>
        <name evidence="13" type="ORF">LDHU3_35.7110</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="9"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIW3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350059200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7110"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000032">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="11">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="387" mass="42771" checksum="D5704276D8BD97AC" modified="2019-04-10" version="1">MTSLSHSPRTRGGARTFFALVNLRSGGRRSSEYVLHKLSDTLGADRVWVLFEGGTAERHRSQLELFLRKQAPKYVIVAGGDGTISFAMDVIKRLHDQNLLSPNRGVIAPFPLGTGNDFSFTLGFGSGFARWIVLGEKRFQRLMRDYETATVTNVDRWSLHVTTTTARHPSGLVHTHVFNNYFSIGFDAAVANRLNRFRGRHPNLFTTRPVVKLWYAAFAVMALFTEKKIGSSILLEVDGRRVPVPASAKSVAVCNMLTYAGGAVAWNGDAVDHYAKPSVWDGRVEIVCFYGIWHLALVRLGWCYGKKLGQGTTACIETDCHSCQFDGEEVLNVADSKGKSTFRILHFSTSECLTVPPRQETNVFVLLLALAAAVLAIVGILYRSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJR1</accession>
    <accession>E9BUP2</accession>
    <name>A0A3Q8IJR1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCDC81 HU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_19610</name>
        <name evidence="6" type="ORF">CGC21_14950</name>
        <name evidence="5" type="ORF">LDBPK_365340</name>
        <name evidence="3" type="ORF">LdCL_360060600</name>
        <name evidence="4" type="ORF">LDHU3_36.7120</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865648.1">
        <property type="nucleotide sequence ID" value="XM_003865600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJR1"/>
    <dbReference type="GeneID" id="13388534"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360060600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7120"/>
    <dbReference type="OMA" id="HYHATVP"/>
    <dbReference type="OrthoDB" id="269134at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040673">
        <property type="entry name" value="CCDC81_HU_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028034">
        <property type="entry name" value="HU-CCDC81"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14908">
        <property type="entry name" value="HU-CCDC81_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18289">
        <property type="entry name" value="HU-CCDC81_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC81 HU" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC81 HU" evidence="2">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5435113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29386" checksum="8A532C1BC9E2B27E" modified="2019-04-10" version="1">MEHSSSCSGRACRGCYGEIAEIVTLVDGVYMLQTKGQGTAHQLNVVWRVLGEQLEEMLIKKRSGIVLDFLHASIKVQRVMLFDKSVAIELKPQLVLLPDFTSKFHLKNVLEMHDAHYHATVASTVSYITIASIVGTDRFVVEAAVKDSVREIGKYLQRNAASTLTIDIGVGFLEFQDRTYRMKWSREFLARMRASVGAAEVVTPYDPPSRTIGGPAAPCRFQKGCTSENLLQTQVRETVLAESRLSAAELNDGMGSSSYRRTHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK34</accession>
    <name>A0A3Q8IK34_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330019000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK34"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1930"/>
    <dbReference type="OrthoDB" id="272823at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="803" mass="86801" checksum="BAD9352BBB146F66" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKB7</accession>
    <name>A0A3Q8IKB7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360016500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKB7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1480"/>
    <dbReference type="OrthoDB" id="273053at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="578" mass="62557" checksum="8EFB08CF0F5560FD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILD2</accession>
    <name>A0A3Q8ILD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-keto-acid decarboxylase, putative</fullName>
            <ecNumber evidence="14">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_340039100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILD2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340039100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5150"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="202"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="384"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="540"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU82669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="583" mass="63894" checksum="4F05F56B4F6A4CB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM39</accession>
    <name>A0A3Q8IM39_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_230016700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM39"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1360"/>
    <dbReference type="OrthoDB" id="267601at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018738720" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="44930" checksum="7CDB8091AC57240E" modified="2019-04-10" version="1">MFTNVLLKHLYSRAALLLLLSLLASILSPSSVPGITHVYAAPSPAMEVAPSGSTFSWQKMRNIMVTAAIAENVMTKTLPQNLPSTAVAGVVVTTSTSSLAASAMPLNDKHVLVPGISVSPEEVAAKVNGASFTQTDASVSSVGSQPPLEDANELLRNYAQPMTALYNSVSAPGTEEIYFIENVTYKVRILFSGPSARWSISLSKSRDNVSVTIVQAIEVFSNSRRMICTPTVDSMRVMEKDPELKQIGDGHGGLIVDITVNCGGTNFMIGRFLDSSEYASTLDFLNTTNITAAFQSSSRSSSRVDVYTTMVRGGENTFICDRVCKGMIAMGCLIVGLCAVCVAITLVAICCPCYCVRADWGNSTDNSTTFDYPDCSNADAESSRLDMLQEGMHVYGDQNASHYFATVPKRTMSFSKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPB5</accession>
    <name>A0A3Q8IPB5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260023800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2390"/>
    <dbReference type="OrthoDB" id="267537at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008507">
        <property type="entry name" value="DUF789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05623">
        <property type="entry name" value="DUF789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1881"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2115"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1890"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2123"/>
            <end position="2163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2317" mass="238092" checksum="C27EB79BCE22D927" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IU44</accession>
    <accession>E9BQF2</accession>
    <name>A0A3Q8IU44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerolphosphate mutase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Histidine phosphatase (Branch 1) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_37525</name>
        <name evidence="5" type="ORF">LDBPK_332220</name>
        <name evidence="4" type="ORF">LdCL_330029200</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864047.1">
        <property type="nucleotide sequence ID" value="XM_003863999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IU44"/>
    <dbReference type="GeneID" id="13392443"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3200"/>
    <dbReference type="OMA" id="FRVPMEV"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="502" mass="55447" checksum="0ABA418E6159E125" modified="2019-04-10" version="1">MWWTAARRRLYYPNQIFISKDNRRIENSWLPRRLLLVRHGESEANVNREVYSNTPDWKIPLTALGREQAYDCGKRLRNIIQGEKLYIYYSPYARTRQTLSEIRRSFDESQIQGEREDERLREQEMGNYQPLQDMDATWAARHAFGRLYYRFPFGESGADVGDRVSGFFDSLLRESIGLTVPNMNECVVQGAREGLGGLDLGLWSTGVDNVPGSSCGCSASSSQGGPAASSTGSESAPPSWTPSPHHATTSSTGLRRTIRRTSPHHPLPLSGLGEVEARGVLPLNDHGASAGEDQNVLIIAHGLLIRLFIGRWFRVPMEVFETMCNPPNCAIIVLERDDRLGRLVMTDISKSLFGSDPLLQMMRFDGHEDTRWYREKFLGIVDPTKAAEEAVAEDDDENHYSMSNAHNSGVGAPAPPPRQRKPSTSAATRSSPSTSAPASGTSTSSAESADASASTAGHAALAARDRTTQSKCPHPCMDCTPNRDYMKFCRDADDTPTMGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IW24</accession>
    <name>A0A3Q8IW24_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase superfamily domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360034400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IW24"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3900"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="366" mass="40003" checksum="F7E29E94A2415966" modified="2019-04-10" version="1">MPVGAAALCEYYGYLPRLVRHTGLLPSTRTSVTSSMAPTVLHSSLYEVDPSPPVRSGEVELPSTYSLDKPLVYDIAELPPKPVSSLRLVIISDTHERHREMSVPNGDVLVHCGDIQEGLNFVRDVKAMLTDFSAWFTDSALHPHPVKLIIAGNHDKAIAAMSTEDVRRLFEPAVYLCEDSVVVEPVGVRFYGSPRSISNSRWSPNTAFQDKKAWKPFMFASARQDDGPGAVSTASRCSSEQPLRARFEGATPGGSVDVLVVHQSPDIPRAHHSVEEQPICTYTQQVAPRRVLLCGHLHGAHGMHRLPVPELVRKSFRVATRGGGGQPEGVARLDEIPFLPCINAAMMVGRFGQNVLLPPSVVDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IW98</accession>
    <accession>E9BUC9</accession>
    <name>A0A3Q8IW98_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14385</name>
        <name evidence="3" type="ORF">LDBPK_364210</name>
        <name evidence="2" type="ORF">LdCL_360049200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865535.1">
        <property type="nucleotide sequence ID" value="XM_003865487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IW98"/>
    <dbReference type="GeneID" id="13388421"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360049200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5640"/>
    <dbReference type="OMA" id="ITGHMVQ"/>
    <dbReference type="OrthoDB" id="270755at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="526" mass="58296" checksum="8EC5D07701F6D7EB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H545</accession>
    <name>A0A3S5H545_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_030009900</name>
        <name evidence="10" type="ORF">LDHU3_03.0500</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H545"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0500"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF96">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5427080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="572" mass="60979" checksum="363D34E434D1FBD2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5G6</accession>
    <name>A0A3S5H5G6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050007000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0250"/>
    <dbReference type="OrthoDB" id="239796at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1495" mass="158552" checksum="09F07DB688424B4A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6K2</accession>
    <accession>E9BAX9</accession>
    <name>A0A3S5H6K2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_120050</name>
        <name evidence="3" type="ORF">LdCL_120005500</name>
        <name evidence="4" type="ORF">LDHU3_12.0080</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812632">
        <property type="protein sequence ID" value="CAC5428245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859116.1">
        <property type="nucleotide sequence ID" value="XM_003859068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6K2"/>
    <dbReference type="SMR" id="A0A3S5H6K2"/>
    <dbReference type="GeneID" id="13390187"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0080"/>
    <dbReference type="OMA" id="FVLNEPM"/>
    <dbReference type="OrthoDB" id="269317at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000171">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="2">
        <location>
            <begin position="30"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="423" mass="47449" checksum="571205E176402F8D" modified="2019-04-10" version="1">MAQPQDSASISSDELVVWRAAERVRQGASLQLSRVARCIASATKLLKVEAKVMERVCGDTIVFGPIRGHAADFANILLTKVLPNRCVKNIVFLGNYIDGAHQSLGVLFLIAALIVCSRFHIVPLIGKHEMMYPIQPETFGSLRNEMLLCCTRRRQPLEQYESIMKEFFSVLPIACVVENRFFCVAGGPSSKFRTLEEIELITLTQDASKEFALNKPMDEDEERIADGSAFVASQENELAFRYTFNAACNFLSRNKLAMLIVGMEYHMSLPDYDSFARPNHYKESIYFPGYMLGRIHPETQLPAVLSMFSAPSFCGVNRNNACIAEIADNRLVVQELGVYAKRPLVSPGTQDHAFSWAQPMLERAVVVIARDIIRGVVKEDAATDDDAHRKRLEEVAVSKMRRMCMLLRAHDLPLPDVPKLAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6K3</accession>
    <name>A0A3S5H6K3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plus-3 domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Plus-3_domain/Zinc_finger_C3HC4_type_(RING_finger )_containing_protein_putative/Pfam:PF03126/Pfam:PF13920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_120006100</name>
        <name evidence="5" type="ORF">LDHU3_12.0150</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812632">
        <property type="protein sequence ID" value="CAC5428251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6K3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0150"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000860">
        <property type="entry name" value="Plus-3 domain/Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000007">
        <property type="entry name" value="Plus-3 domain/Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Plus3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5428251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="275" mass="31987" checksum="710977CB42748F29" modified="2019-04-10" version="1">MLQRLQLFRSTLVNFLEWRNFSDVVHGCYVRVLLEMRSTEENRRESPDNYYIALVKGAQRGPVYSGFSADAVTTEWHIVIELPPCFRSTQNGNVVQLNSISNSPFRQAEYQNWVDMTNETRELSFPSLPQLQFRLGMLEEHKQQALAPEPRRHRNGEDAQAAALRERVLEEKRKRITEEIMATHVKLRRIDQLKALSLEDLQEVEREILDLITGVRISINERSKCMLCHNRICTEICYPCKHQVLCKDCAKSIRGRCPAPKCKTPVQYTFEAFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H712</accession>
    <accession>E9BDC0</accession>
    <name>A0A3S5H712_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">META domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">META domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_4115</name>
        <name evidence="3" type="ORF">LDBPK_170990</name>
        <name evidence="2" type="ORF">LdCL_170015900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859953.1">
        <property type="nucleotide sequence ID" value="XM_003859905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H712"/>
    <dbReference type="GeneID" id="13393232"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1420"/>
    <dbReference type="OMA" id="MMLGSDD"/>
    <dbReference type="OrthoDB" id="258733at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="112" mass="12076" checksum="797E0593A94D155D" modified="2019-04-10" version="1">MEMKNLLGKHKVVLVNGRPAPAGVTVEFKAGENSGSVHMHARVANIMNGQLRLENRKLSGALVSTMMLGSDDLMNIENALSQGFMEGMTYTVKDGGKLTLQSKTHIIKLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H769</accession>
    <name>A0A3S5H769_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol uptake protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_190018700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H769"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1620"/>
    <dbReference type="OrthoDB" id="261651at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="684" mass="77707" checksum="76BE9C32D7486507" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7N3</accession>
    <name>A0A3S5H7N3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_300028300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3080"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1605"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1665"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="645"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1672"/>
            <end position="1698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1698" mass="184260" checksum="88A45927BE7B229C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7Y3</accession>
    <accession>E9BRR3</accession>
    <name>A0A3S5H7Y3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeats (3 copies) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ankyrin repeats (3 copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_5760</name>
        <name evidence="4" type="ORF">LDBPK_350310</name>
        <name evidence="3" type="ORF">LdCL_350008100</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864624.1">
        <property type="nucleotide sequence ID" value="XM_003864576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7Y3"/>
    <dbReference type="GeneID" id="13387502"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0400"/>
    <dbReference type="OMA" id="CGCIDDM"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="427" mass="46457" checksum="2049E24CC6DB9CC2" modified="2019-04-10" version="1">MQRKYTNAQALAVYQALQQSGGLSALEDDTATALYLSQNAAATGELNFTPGLLERLTKRLDKGGMVLDPFCSYDYADRRHIRNFSMSIPIPFSAFDGIRRSKHQVQLTAAQEENVLKSFDKLLNGEDVKKSGATPAAKGAREISVALPFVSAFFDQRCPELHNSVLTGSREGATYLLLSVITGHKELCAKCLKAGANPNNMSFLRDESPAPGDMFHGYSPVFMAVLAEQVEILELLCSCGGSIHVYDRWGRTPLHAAMAVESTLTVQWLLAKGAPLYVPDGFGILPADSCVGTQYAEYSMPMLALQEPPKCPPPSYFAEAAKSWAAPERESKPTAEKESKEDAATTSSGASAAEGEIKMELCRCRSGRPVGFCGCIDDMLVRWARDRLNTEWSPGVNFSALAKKQAAVEEERKRTTYSADGGRVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPR4</accession>
    <name>A0A3S7WPR4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_070005500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPR4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0090"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="4"/>
            <end position="5"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="961" mass="107666" checksum="C99BDC45F7C04D7B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR69</accession>
    <name>A0A3S7WR69_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_100012400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR69"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100012400"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12051" checksum="3DCF478E1CDE5F06" modified="2019-05-08" version="1">MPLFTGFNFNTASFQKCVPEKTGDGGICIGHLIFRKDMEVLASKLIDEIREDQSWLRESGYFSVGGPCIGLPDQRCAPAERGGLSESLDMCELHQGAMGRTPRVPGCSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR98</accession>
    <name>A0A3S7WR98_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine/AMP deaminase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_100015700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR98"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1250"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="80222" checksum="72D19DD5416D84EA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRN0</accession>
    <name>A0A3S7WRN0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (Many copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_110012400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRN0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0900"/>
    <dbReference type="OrthoDB" id="269113at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="226" mass="25214" checksum="853D59428DC89AD6" modified="2019-05-08" version="1">MPNAKNGSETTYFTAIANRDVEALKALIAQNRNVNEVAQDPALYHRTPLHICVWENFVEGAKLLLDAGADVNALDDLHDSPYLLSAAEGRQEIMEHIYKNAERTMRYGSQTSLRMKTSVPDHSIVNRFGGSALIPACERGYVEMVRLLLQKGVDVNHYNYYHWTGLLEAIELGGDDREHVDIVRLLIENGADVNKVDGAGKTPLYLARKRKYKRIAALLEAAGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSC4</accession>
    <accession>E9BB90</accession>
    <name>A0A3S7WSC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_33025</name>
        <name evidence="3" type="ORF">LDBPK_130150</name>
        <name evidence="2" type="ORF">LdCL_130006500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859227.1">
        <property type="nucleotide sequence ID" value="XM_003859179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSC4"/>
    <dbReference type="GeneID" id="13390814"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0190"/>
    <dbReference type="OMA" id="WASRDSH"/>
    <dbReference type="OrthoDB" id="271704at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="473" mass="51803" checksum="7C50DD78552AF7D3" modified="2019-05-08" version="1">MIPKGCVVQGFREVFAPVSVRAYRHYGFLVAENFLPASLAHQLTTMCNMAVRQRGDNIFPGLDAQHRLGATVAPNSKLKPLKTPGGAADTGAKPLHPATPPLASSTSLGFGNAPLRPGRQKEDEAAVRDRHAGTRARKIHIMLRSRRAVDRVYRRLTKARERYNAHRRVGGYVTAEEEMAGNMTEERIQELQSKYTYEDFQRSLQHSRDSGLLETGFRRDHYINDAMTFMQDWPRTWCWLWRTSPELKALAVSAEGAVGQLVGEAAGYLAGEVVLRVYSDSATEATSLSNATPMGFAGVATNFAHPHALSAQLGLERPNSAHLDAATMVMPGSHHIVWRISLDGKELDRFQPGGIFDVGSMVRALPEVSHLPVVALPPLNPGAVLFFNNYLLMGTQANLYGAAQNATGTVAAGPVAHATSYALSLIPDRCVFDGKRNSWASRDSHGPLYSYKRGQLLTDDAAFPVIHRALDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU54</accession>
    <name>A0A3S7WU54_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_160020800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU54"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1880"/>
    <dbReference type="OrthoDB" id="271898at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019024591" evidence="2">
        <location>
            <begin position="39"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="640" mass="69525" checksum="F6158F102B209C50" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUJ3</accession>
    <name>A0A3S7WUJ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_170017100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUJ3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1550"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000771">
        <property type="entry name" value="Hydrolase, alpha/beta fold family-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF7">
        <property type="entry name" value="ALPHA_BETA FOLD FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="336" mass="37412" checksum="9ED8C4E86932E915" modified="2019-05-08" version="1">MMSPEITETDEAENMPRELRGKGKPMPCDKFVRVGRCHSTRKEVIICYRTLGDPSNPCLLLVIGLGGTLLHWPGEFLAELLKNGFYLVLFDNRDSGLSTHFDGYPTPCLPCMVFQSWSPLCGGAPPYTLYDMANDAWCLLTALGIGRAHILGTSMGGMIAQCMAIEYPKRVCSLTICYSHSSGPYVKPQACRVTLALLDKPASLSLKDVEDYVVRSDCLFRGDYPLDEAHVREVAAANFMRSPPYKSGLLRHVWAVQRASNRESALRRLRGFPVLVVHGRKDLMIPYENGLRLACVLCNAKLVLFPHMGHSIPRPLYVEIATEVGLQKLRMVNVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVD3</accession>
    <accession>E9BE68</accession>
    <name>A0A3S7WVD3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Methyltransferase_domain_containing_protein_putat ive/Pfam:PF13489/Pfam:PF08242/Pfam:PF08241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_190730</name>
        <name evidence="5" type="ORF">LdCL_190012300</name>
        <name evidence="6" type="ORF">LDHU3_19.0810</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860251.1">
        <property type="nucleotide sequence ID" value="XM_003860203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVD3"/>
    <dbReference type="SMR" id="A0A3S7WVD3"/>
    <dbReference type="GeneID" id="13386063"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0810"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="385" mass="43712" checksum="591AEF05B5C0829C" modified="2019-05-08" version="1">MPSPLVLTRAAPARGLNVKMFDRKVKGLQRSFVSSPACDIHKLCAQQMLDRRAFVKRDTPVVLEVGAHTGWYLRHMIERKELHGLKQYIQTDISEDRLNRNYEEIKDIIPPEVEFVQICCDEEQPSPFGIPDKSVDMVVSCLSMHWVNDLETSMVNVRKVLKRDGFFLNAMFGGNTLYELRGCFSMAQTETLGGVSPHVSPMIDGAGLSTLVLQAGFNIPTIDLDRHLLLYETPFHLMEHLAVMGESACHYMRQPMKRDVLLCACAIYDTMYKQNGLIPATFEVFHTIAWSPSPTQAKPLARGSGQIPLSSWNSKSRKQLQSVLDEYALNPNDEVLQNKAEDIFKKLREESAELMAKKGLDSRGFERDRDEEARRLDEKPVPPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVY3</accession>
    <name>A0A3S7WVY3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LdCL_200012500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0970"/>
    <dbReference type="OrthoDB" id="267132at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22961">
        <property type="entry name" value="DD_TEX55-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000805">
        <property type="entry name" value="Mitogen activated kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="9" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="1942"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="2063"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="2385"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="2773"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="3550"/>
            <end position="3813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="700"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1232"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1389"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1429"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1595"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1734"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2113"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2274"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2485"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2690"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3135"/>
            <end position="3227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3247"/>
            <end position="3301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3368"/>
            <end position="3394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3843"/>
            <end position="3960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3514"/>
            <end position="3541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1285"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1318"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1447"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1595"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1661"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1673"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2310"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2320"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2492"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2564"/>
            <end position="2583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="2606"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="3189"/>
            <end position="3199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="3255"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3281"/>
            <end position="3294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="3844"/>
            <end position="3867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="3903"/>
            <end position="3919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="3934"/>
            <end position="3944"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="3579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU78357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3960" mass="414518" checksum="1A6F547CBCD5378E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXL7</accession>
    <accession>E9BG41</accession>
    <name>A0A3S7WXL7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_18480</name>
        <name evidence="5" type="ORF">CGC21_17585</name>
        <name evidence="4" type="ORF">LDBPK_230210</name>
        <name evidence="2" type="ORF">LdCL_230007000</name>
        <name evidence="3" type="ORF">LDHU3_23.0260</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860922.1">
        <property type="nucleotide sequence ID" value="XM_003860874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXL7"/>
    <dbReference type="SMR" id="A0A3S7WXL7"/>
    <dbReference type="GeneID" id="13389883"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0260"/>
    <dbReference type="OMA" id="RRASMFV"/>
    <dbReference type="OrthoDB" id="277948at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="125" mass="13884" checksum="482E87B51E9A3EE6" modified="2019-05-08" version="1">MNSADALEPIPRSIAPDQELAILKLILDLRSLGDVDGSKKIRRRVREALLKSSDDSEAMSKVDDIIRRGKRTQSKLDGSYEERQRLKRKRREEDLAAASRLVDVEAGSGEDSEGSASTEEDGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXY4</accession>
    <name>A0A3S7WXY4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230025700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXY4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2440"/>
    <dbReference type="OrthoDB" id="257475at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019409512" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15592" checksum="E252587C241944E4" modified="2019-05-08" version="1">MRRNTFLADVAPAALLVCFLCGVVLNTAAHIEGPRMSPVLQCSEDFSLVCAGSTSTRNLWGCMMKNADKISNELCREYVIGFYACTRDAEKRGSCVYPAADYATSVRRCLRTIPGDRISEECRSSRFYSPIAELIAAKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0A9</accession>
    <name>A0A3S7X0A9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAAX prenyl protease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_270005300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0A9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0060"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000016">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="220"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="427" mass="49133" checksum="FCBC725B912DA3FE" modified="2019-05-08" version="1">MSSSPNLFLRAAVVSLNVIGMWDAYLVLRQRRANQTKEMPSYFRKDITDEEFAKAQAYEGEKSTFSFLQHLKGLVITNMGIFLRLPAFLYYLVAQRASLSTGSFSHNYAAAVAGELISVVLDIPFSFYENFHIEDRHGFNEMTKTEFVKDIVKTLLLRVTLLYPLQIKLIQFVVQRFGERFPLYLFLGMSVMLVVFLLAMPTVIQPLFNKFTPLDAESTLYKKIELLSKEMSFPLKKVFVVDGSRRSHHSNAYFYGFGSNKRIVLYDTILEQLRDDDESIIAVLCHELGHWKHNHIYVNLAMVLGQLMLISYGARLVVFDKRVYEAFGFGEVDPVIGLNIFAEMFYEPLSTFIGYGFCYVSRRHEFQADRFAVTHNRGEGMKKALLVISKENRASLTPDPLYSALHYTHPPVLERLQAIDAELKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0U4</accession>
    <name>A0A3S7X0U4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Frag1/DRAM/Sfk1 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_270023700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2550"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000122">
        <property type="entry name" value="Frag1/DRAM/Sfk1_family_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1390" mass="157108" checksum="3E55412E663BE4F0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X159</accession>
    <accession>E9BK52</accession>
    <name>A0A3S7X159_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-direcetd RNA polymerase II, subunit 9, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA-direcetd_RNA_polymerase_II_subunit_9_putative /GeneDB:LmjF.28.0120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_14010</name>
        <name evidence="5" type="ORF">CGC21_21610</name>
        <name evidence="3" type="ORF">LDBPK_280120</name>
        <name evidence="1" type="ORF">LdCL_280006100</name>
        <name evidence="2" type="ORF">LDHU3_28.0150</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862113.1">
        <property type="nucleotide sequence ID" value="XM_003862065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X159"/>
    <dbReference type="SMR" id="A0A3S7X159"/>
    <dbReference type="GeneID" id="13386849"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0150"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000040">
        <property type="entry name" value="Putative DNA-direcetd RNA polymerase II, subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="140" mass="15624" checksum="12997B16D525315E" modified="2019-05-08" version="1">MEAEEITQVSIGNATTAPMLFCSRCNNLLYPECDDDNYSMTWRCNYCKTTEQHDDCKLVHVMNLKMKADAIGGMDLIAEFANDPTAQRDPEKPCPKCGKKGVACFVNPLGQPQEDMTLYFACSDTVCRHVWKGAAAEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X253</accession>
    <accession>E9BKJ4</accession>
    <name>A0A3S7X253_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_25835</name>
        <name evidence="7" type="ORF">CGC21_27785</name>
        <name evidence="5" type="ORF">LDBPK_290480</name>
        <name evidence="3" type="ORF">LdCL_290009600</name>
        <name evidence="4" type="ORF">LDHU3_29.0680</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862465.1">
        <property type="nucleotide sequence ID" value="XM_003862417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X253"/>
    <dbReference type="GeneID" id="13387204"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0680"/>
    <dbReference type="OMA" id="MRSCLRF"/>
    <dbReference type="OrthoDB" id="263759at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="448" mass="46861" checksum="68030A17D4B00F58" modified="2019-05-08" version="1">MQTCISRHHTSKLTLVGTYVGSKVAKAVLMSAAAGKLTPEIVGEALMSSSTIRGHVQREAVRLLVVRISMRAPQQLQWLLNLIGDCAGSLSATDALSSLAKRSLFYQVTSFGLHGSAASAITTAALQIGMTTCTLLTSNAALWRDQDSRMSLRQYRYELLTSLYTSVGTVAGGAAGAAVGSMVMPGIGTAFGSVLCSVGGGYVPGYLRDKKGPDDRRRQQATALRRFTPLRMHDTQDGAVFMSMEELAEASPIAPASAAAQVSEALKAMQELQDTGDTSARDGGAAKATEVDSENGDAEVGDEPVWLDFVRSETPGTISLTESSADTKASIDGEDGSQAPLMRSCLRFSPSLAVLSKKGSIHGDCSSGAQSSGTSFQEADPVSADAAMITSLSSAPSSFCDAVDAETATTAAERFEGRAKYVTASTAEELQRELEKCGGDSDVLFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2B5</accession>
    <accession>E9BKM9</accession>
    <name>A0A3S7X2B5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_27930</name>
        <name evidence="4" type="ORF">LDBPK_290830</name>
        <name evidence="3" type="ORF">LdCL_290013100</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862500.1">
        <property type="nucleotide sequence ID" value="XM_003862452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2B5"/>
    <dbReference type="GeneID" id="13387239"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1130"/>
    <dbReference type="OMA" id="FGMAPGK"/>
    <dbReference type="OrthoDB" id="273765at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="62860" checksum="6601DFF632B3FDA1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2V4</accession>
    <name>A0A3S7X2V4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_290036000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2V4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4370"/>
    <dbReference type="OrthoDB" id="261218at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="773" mass="83693" checksum="AB90799A81C96AC5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Z5</accession>
    <name>A0A3S7X2Z5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290033300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Z5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290033300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4000"/>
    <dbReference type="OrthoDB" id="273514at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="719" mass="77470" checksum="9B848CE828946DF9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X384</accession>
    <name>A0A3S7X384_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300017800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X384"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1640"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="493"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110844" checksum="7FF0CAFDB442E547" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3V7</accession>
    <accession>E9BM87</accession>
    <name>A0A3S7X3V7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CAS/CSE protein, C-terminus family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">CAS/CSE/importin domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_36405</name>
        <name evidence="10" type="ORF">LDBPK_303440</name>
        <name evidence="9" type="ORF">LdCL_300040000</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863055.1">
        <property type="nucleotide sequence ID" value="XM_003863007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3V7"/>
    <dbReference type="GeneID" id="13385764"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300040000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4550"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001036">
        <property type="entry name" value="Putative CAS/CSE/importin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="975" mass="107995" checksum="7CF3278668A3F080" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X481</accession>
    <name>A0A3S7X481_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310010400</name>
        <name evidence="3" type="ORF">LDHU3_31.0720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X481"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0720"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9230" checksum="F69113087D60616B" modified="2019-05-08" version="1">MKRLLLFDPSPQAATSRVPQDAGNSGFAGIASWVRSTAPSGQESVEHRVGVIVRHSCALLAHIAEKRITYLLYPRPLKMRMTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4A3</accession>
    <name>A0A3S7X4A3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium stibogluconate resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310016100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4A3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_073400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310951.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1500"/>
    <dbReference type="OrthoDB" id="261177at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744:SF1">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="621" mass="68057" checksum="4317603A1D331959" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4R8</accession>
    <name>A0A3S7X4R8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310028800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4R8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3750"/>
    <dbReference type="OrthoDB" id="266252at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="500" mass="53231" checksum="0BBF3FC2AC36FF56" modified="2019-05-08" version="1">MPLYAPLGIRFSDDVNARARLERQRIARLNSILRHGSDEQRRQALKMKPLPLPEDSEALAVPGTAVLDLPGGADESLDSRNETGVFDPLDAVAQRYGGAPYNDDDRRAAARGVDYSVFMEVLCPNGSSLLESLPLEPRTLRPHFKGSSSESKKSQFESALSSPRCGLHTRLPSTAVAAAMPEASLSLGHNAFVARGPPSASFVNTSTVSEASVQSGLDEAYVDAPINLGSEAASLSAPSAENGFATPTHGVADPASDAARATAATHADDDDTAPDIFVSAGSFSLAPSHRSSRWHSLLSFRRSPSGSSKASHTDSGHRNARSVANLSLTRSLSQRALKSSSELSLPASGATSAQLTPLAAADGCDLGGRVIFTDRFVKAQSHTALPTMISAFKQYMRSASSATACSSLTHSQTLDIYTPYEHWSSLQHQQLQNAHQHLGPCHRGIPLKSDNTNKEIENCVLEAGKCVRPTFRRMDPADLYGTSHYISGAFIKVAKPSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5P3</accession>
    <name>A0A3S7X5P3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320026600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5P3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2630"/>
    <dbReference type="OrthoDB" id="252091at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13869" checksum="A99D75BB75680551" modified="2019-05-08" version="1">MADQAPPGVNMPKKRDPRLRQMQAPQQQKFFDSADYEVRKQQQQPSQQQQQPSQQQQQPSQQQQQPSQQQQQPSHGQMAPNGIPRRGPADGLHLGAADGGAPRGKNPPPPPLPDGYAVPGARRTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6J0</accession>
    <name>A0A3S7X6J0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta tubulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_330014400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6J0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2650"/>
    <dbReference type="OrthoDB" id="257378at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="244" mass="28048" checksum="BB1C0C72ECA662BE" modified="2019-05-08" version="1">MCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEEEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X748</accession>
    <name>A0A3S7X748_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_330034800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X748"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330034800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3910"/>
    <dbReference type="OrthoDB" id="10259804at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001622">
        <property type="entry name" value="Dynein intermediate chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="376"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1084" mass="114929" checksum="02096677F6621830" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X793</accession>
    <accession>E9BQF5</accession>
    <name>A0A3S7X793_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/Enoyl-(Acyl carrier protein) reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_340010</name>
        <name evidence="3" type="ORF">LdCL_340005000</name>
        <name evidence="4" type="ORF">LdCL_340005200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864166.1">
        <property type="nucleotide sequence ID" value="XM_003864118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X793"/>
    <dbReference type="GeneID" id="13387471"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0030"/>
    <dbReference type="OMA" id="GNMPIPN"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33497" checksum="4FEC5FA28B1FA44C" modified="2019-05-08" version="1">MPCFLSVLGAVALGAIFFKVIGFVKINYLTSLNMKKRYGHAGDWAVVTGASEGIGYAMALDLGRRGFNVCVIARTLSKLESVVADLKQLGVQGKAISFDFASATPKQYDDMFAELDKIEIAVLVNNVGVNYTYTNNFDEVDLETDLRLLKVNCESSVRMTKYVVPKMKAKRCGAILMLGSVSAVTPAPLLCTYAGTKAFNLSFGCGLHYELKEFGIDVLAVSPNMVVSKMTQGISSRKPRETFLMVNADNMAHQTLDKLGSVPQTPGHRNHAVLEAIVRALPTDYVSNKILQTHKSIKCKAERKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8I6</accession>
    <name>A0A3S7X8I6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Unc104-like kinesin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340050300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340050300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6400"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000242">
        <property type="entry name" value="Putative Unc104-like kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057607">
        <property type="entry name" value="PH_kinetoplastids"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25404">
        <property type="entry name" value="PH_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="2"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1488" mass="163803" checksum="183610CF8944365E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8M7</accession>
    <accession>E9BRN9</accession>
    <name>A0A3S7X8M7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_350070</name>
        <name evidence="9" type="ORF">LdCL_350005700</name>
        <name evidence="10" type="ORF">LDHU3_35.0130</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864600.1">
        <property type="nucleotide sequence ID" value="XM_003864552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8M7"/>
    <dbReference type="GeneID" id="13387478"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0130"/>
    <dbReference type="OMA" id="VPFIQNP"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="37"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5434035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ37918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="292" mass="32297" checksum="98A8BF892476A67D" modified="2019-05-08" version="1">MAAEARKKMNAYGGFGNIIGMSALVGVGCVSIYALYKSIFFVPGGFRAVKFNCITGLYNRTYGEGANFAIPFLETPVVFDIRNKPIEVPTASGSRDLQTVNMAVRVLYQPNVDNLYHIYRHIGVNYAETVLPSLINEIIRAVIAQFNASDLLIKRPEVSHRIGVMLAERAKRFNIDITDVSITQMSFGKEYTNAVEAKQVAQQMAERAKFRVEQAEQEKQAAILLAQGEAEAATLVGNAVKRNPAFLELRGLEAARTIAKTLRDHGNGRYYLDSDSLYVNVKDLKIDHSGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAY1</accession>
    <name>A0A3S7XAY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360032000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAY1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3550"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000087">
        <property type="entry name" value="Putative acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF137">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="445" mass="51388" checksum="3C1B4C7813497B9F" modified="2019-05-08" version="1">MNLARLVSAFGLHSARRNKPSTATETSDPVHPRVNINWTQQSLNSNITKAERKEILKSKLVLTKLVVLNRHGHRAPNAPFWKMCPNDIKSKKRYDVSAEDLTGLGMEEEYNFGQYVRNNYHAFIGDKFNRMLHYFRAVGEPRILQSAMAVAQGIFPDGFGPGGYLPSRPQFVPIFSDMDTHEYLLDDVPCFRRAENDSHRWIDKRYQNFIDDPNTGRVLKMIKEVCGEYIRPAEGYAYIKTVADGLTFNSDIGLKVAKGRLTPEMLFSIRNVSLQLLMQRLYDTDEQQTYMAVDLPRNILQTLNHTHVGDTPEQLNDFTDTRQESTFYFMHREALYAFAQFFGFQYNVAGLPPGELPVASSIIMEKLVPHRDQYSHNASRIYVRITLWTPYNGIYTIPISTCRIPELCELKELRYIHDTRVSRTGTWEQLCNYAPQEIDHTTDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB31</accession>
    <accession>E9BU19</accession>
    <name>A0A3S7XB31_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="7">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_28430</name>
        <name evidence="15" type="ORF">CGC21_13835</name>
        <name evidence="13" type="ORF">LDBPK_363100</name>
        <name evidence="11" type="ORF">LdCL_360037400</name>
        <name evidence="12" type="ORF">LDHU3_36.4290</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865425.1">
        <property type="nucleotide sequence ID" value="XM_003865377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XB31"/>
    <dbReference type="SMR" id="A0A3S7XB31"/>
    <dbReference type="GeneID" id="13388311"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360037400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4290"/>
    <dbReference type="OMA" id="DIGCMIN"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000041">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP48417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="413" mass="44070" checksum="7EB604AE54EFAE72" modified="2019-05-08" version="1">MFRFGRLCTPKAAGVQRRFLNIHEYQSKQIIKDNGGRVEFGIACKTIEEVEAACAKIKTEKKVVKSQILAGGRGKGVFKDGFQGGVHVCDSAAAAVEAAKHMLGNTLVTKQTGPKGQLVNTLYVTEAVAGIKRELYLSLILDRKSASPMFIGSAEGGMSIEELAKTHPEKIKTMKVNVAEGVDHDAAVAYAKELGFAGETAERAAEQIKALYNIGKSKDCTMVEINPFVELENGDVMEIDAKLSFDDNAAFRQRGIFALEDQTQIDSKEVLAKKHDLNYIALDGNVGCLVNGAGLAMATMDTISLHGGSAANFLDAGGSASEAQIVAAFKIITGDSNVKSILVNIFGGIMHCDVIAQGVVNASKALNTTIPIVVRLCGTNEQRGKEIIRNSGLVIHPVEDFDSAARKAVELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBB0</accession>
    <accession>E9BU62</accession>
    <name>A0A3S7XBB0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_28210</name>
        <name evidence="5" type="ORF">CGC21_14060</name>
        <name evidence="3" type="ORF">LDBPK_363530</name>
        <name evidence="1" type="ORF">LdCL_360042300</name>
        <name evidence="2" type="ORF">LDHU3_36.4810</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865468.1">
        <property type="nucleotide sequence ID" value="XM_003865420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBB0"/>
    <dbReference type="SMR" id="A0A3S7XBB0"/>
    <dbReference type="GeneID" id="13388354"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360042300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4810"/>
    <dbReference type="OMA" id="DRQDEPG"/>
    <dbReference type="OrthoDB" id="268840at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd23017">
        <property type="entry name" value="mt-LAF19-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="102" mass="11881" checksum="18DAE93117EF24C8" modified="2019-05-08" version="1">MGLKRLAKATKITSKHMLLLNRREPYKPVTSDRVMIENRRRLEDFEAKNAEGIVFVPDTALPPWQKSIATNLKQQATQMNFRGFRVRVADKQDEPGFPTHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBG7</accession>
    <accession>E9BUB8</accession>
    <name>A0A3S7XBG7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 9">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_27950</name>
        <name evidence="16" type="ORF">CGC21_14330</name>
        <name evidence="14" type="ORF">LDBPK_364100</name>
        <name evidence="12" type="ORF">LdCL_360048000</name>
        <name evidence="13" type="ORF">LDHU3_36.5490</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8 9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 9"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865524.1">
        <property type="nucleotide sequence ID" value="XM_003865476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBG7"/>
    <dbReference type="SMR" id="A0A3S7XBG7"/>
    <dbReference type="GeneID" id="13388410"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360048000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5490"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000012">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="190"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP42048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP48516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="437" mass="47768" checksum="1ADF7200EE84DB73" modified="2019-05-08" version="1">MADYKVKDISLAEWGRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLIETLKALGAELRWSSCNIFSTQDNAAAAIAKAGVPVFAWKGETDEEYEWCIAQTVKGFSGDGLPNMILDDGGDLTNLVIDHHPELVPKIFGISEETTTGVKNLYKRLSKGNLPISAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVTEVDPINALQASMEGYQVALVEDVMADAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHFDTEIQVGWLEANAKEHVEIKPQVDRYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSFTNQVLAQIELWSNRDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEYINCPVNGPFKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBS3</accession>
    <name>A0A3S7XBS3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_360061500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBS3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360061500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7250"/>
    <dbReference type="OrthoDB" id="273207at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="987" mass="107194" checksum="2D0B85D1092FF032" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBS4</accession>
    <name>A0A3S7XBS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial chaperone BCS1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360063800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBS4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360063800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7510"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="443" mass="48851" checksum="04C9A7CACF7CA2F0" modified="2019-05-08" version="1">MWHAIKNTFVTTLEVRSSSQEFAMIVDWMGRQPRGQRIRNLGLKPITVQDEQKTVWGDTPSPLSDDVAASADVDARVTLVPGYGSHLLRFGSTWVYITRAEDPSKQKAAAANRVDRENDKLTLTFFTRRRAVVQQFMTHVQESWRANVRNTVHIYLSEGYGPRWHLLSERIRRPLSTLYLPADTKTVVEEARLFLQLKDTYAALGIPWRRGYLLEGPPGTGKTSFVMALAGELGLPVHILSLRSDNMDDDALLSLTSSLPRRSILLIEDLENVLKTPPEIGRSALSSSASDTAAVAAAETSAASPASPYSTDIGGGPRSAMSLSALLNALDGVSSSEGRLLLITTNDTSRIPFAEVLLRPGRIDRRIRFQPLHAEQLREMEASFQQALQASPCSAVENLRLPSASLSAHEDDRSITCTPAQYQQRLLDAVYASLTSRSRPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBW7</accession>
    <name>A0A3S7XBW7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360066900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBW7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360066900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7860"/>
    <dbReference type="OrthoDB" id="277587at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="86099" checksum="25257B171DCABF81" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC04</accession>
    <name>A0A3S7XC04_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360069700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC04"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360069700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8270"/>
    <dbReference type="OrthoDB" id="264469at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="623" mass="70279" checksum="1049E128CE0DE992" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJI7</accession>
    <accession>E9B7J5</accession>
    <name>A0A451EJI7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_37100</name>
        <name evidence="5" type="ORF">CGC21_30025</name>
        <name evidence="4" type="ORF">LDBPK_020480</name>
        <name evidence="2" type="ORF">LdCL_020010300</name>
        <name evidence="3" type="ORF">LDHU3_02.0600</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5427010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000040">
        <property type="protein sequence ID" value="TPP43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000062">
        <property type="protein sequence ID" value="TPP43968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857943.1">
        <property type="nucleotide sequence ID" value="XM_003857895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJI7"/>
    <dbReference type="GeneID" id="13390078"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0600"/>
    <dbReference type="OMA" id="IDAYAMK"/>
    <dbReference type="OrthoDB" id="263943at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="170" mass="18538" checksum="52E8EBCEA7165981" modified="2019-05-08" version="1">MLRPSVRMTTRAQTSRVCSFHAGLASVTETPFSALAGGAVRPQPRSLAQSVRRGACLRRAETATTTRTSAFSPCCTSTAPLFTNAKNSYARGTEEEQQARQEAAVKEWRDFLDQPVDADGGNAPSARHVEARLPTMKQLNEELPTAAELEKALREGKIDAYATQPDRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9B932</accession>
    <accession>A0A3S5H5W6</accession>
    <name>E9B932_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_070370</name>
        <name evidence="2" type="ORF">LdCL_070007200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858478.1">
        <property type="nucleotide sequence ID" value="XM_003858430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B932"/>
    <dbReference type="GeneID" id="13391793"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0280"/>
    <dbReference type="OMA" id="HCVAERR"/>
    <dbReference type="OrthoDB" id="265179at2759"/>
    <dbReference type="PhylomeDB" id="E9B932"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="253" mass="26604" checksum="4C31131E436BD295" modified="2011-04-05" version="1">MPHFSLPAHEADTPPEPLDADSRRHSCGDDVELCCRLTAAEELHGHLRDCFSLFASRFEHTTVALACIQALFPSSPPPARSGALPGTPEASEAEADAPRSAGGAFDLSTVATVLFLHVEDKLGACLGAAAGSDDEAKTPLLGVVVAFQYWRGFHCVAERRYASAAEAQGEAAALERGNLTVSELLRMPQWELISEPAAEASLSPTPGSGHAKLNTSPGSTDLTSGFSGIEENTVAKHGAAYESLMALMVDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9P6</accession>
    <accession>A0A3S5H6A8</accession>
    <name>E9B9P6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein 5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_090100</name>
        <name evidence="4" type="ORF">LdCL_090005900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858689.1">
        <property type="nucleotide sequence ID" value="XM_003858641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9P6"/>
    <dbReference type="SMR" id="E9B9P6"/>
    <dbReference type="GeneID" id="13392021"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0130"/>
    <dbReference type="OMA" id="IMNSHVL"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="PhylomeDB" id="E9B9P6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF54">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26711" checksum="0844B3E010E12A7A" modified="2011-04-05" version="1">MMHPQPAAQFVNDDTLKQSRNVYVASLPLSFDDQQLQDLFSPYGRIVSARIMRAKKSHASKGYGFVMFREVSSAEKAIEGLHGRVVDGSRIQVRRANADASMTFSKVLHTPVCPRSTPSTQSNSTTSVLQYTIPDAPAQHVMYSAALPQAATGLYAAQPSTSPYAIVAPRAYQSHNPTPVSINPSYGAVMNPHVLQEQNGGIGATYFSHVQSHQVPVQAVQQQQPVYVVLLPNGQHIVQPNQFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9T9</accession>
    <accession>A0A3S5H6D4</accession>
    <name>E9B9T9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_090520</name>
        <name evidence="4" type="ORF">LdCL_090010300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858732.1">
        <property type="nucleotide sequence ID" value="XM_003858684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9T9"/>
    <dbReference type="GeneID" id="13392045"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0650"/>
    <dbReference type="OMA" id="RNGCEHS"/>
    <dbReference type="OrthoDB" id="256429at2759"/>
    <dbReference type="PhylomeDB" id="E9B9T9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000058">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF489">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="425"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="652" mass="70767" checksum="639058EC01AB07A7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCX5</accession>
    <accession>A0A3Q8IAM2</accession>
    <name>E9BCX5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_161210</name>
        <name evidence="2" type="ORF">LdCL_160017300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859808.1">
        <property type="nucleotide sequence ID" value="XM_003859760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCX5"/>
    <dbReference type="GeneID" id="13393145"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1480"/>
    <dbReference type="OMA" id="MAMSNMA"/>
    <dbReference type="OrthoDB" id="266365at2759"/>
    <dbReference type="PhylomeDB" id="E9BCX5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="486" mass="52528" checksum="23D7015EAB9A34B2" modified="2011-04-05" version="1">MSFPLPPSPPAPMSHVAQQQELMRVYREELQLQQRLKEQCRLLQCLAEAAAGMFSWWREGAAAAAAATTDNALLVAGRSPISEGSAGSDANTGEFALPSASSLLKLHSGMVFYSLGELLQLWAATTAPSDFGSNSEKGTDESASAAETMRQGGRDASRREVHASSYDPRRVNECSDQHPPPWSFPTSIAVPVPRIIGEAGHVPHTPPTSPPPLQLPTPAQLIRYRVLDAACPLPVTHRLLLGSVDADNFSLLLLWLMRLTKECAEAMLLWRPDRHMREAHMRSARIEGHRSSSAGADDNRRPLRAVPTPAVIENEAAETIGTKRSRPQDGGSLRCSDGSVVSESWNALCASLIRVLSYLVAAAAEASPRTGSERRQSTEPLLPSLVSCMASAATSVALRADLRLFLAEVAEVRDTVLEVKQYCRVVDAHRDDTERALKRPRGESAAAAVRPPPASVAGKEQPMAMSNMALLAHLAAIVDVQVRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCY8</accession>
    <accession>A0A3Q8IAN3</accession>
    <name>E9BCY8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="3">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_161340</name>
        <name evidence="12" type="ORF">LdCL_160018600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="3"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859821.1">
        <property type="nucleotide sequence ID" value="XM_003859773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCY8"/>
    <dbReference type="GeneID" id="13393152"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1630"/>
    <dbReference type="OMA" id="KLIPMIC"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="PhylomeDB" id="E9BCY8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DAGKc" evidence="11">
        <location>
            <begin position="235"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="732" mass="78155" checksum="2D38650E71B85E7A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEC2</accession>
    <accession>A0A3S5H768</accession>
    <name>E9BEC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_191300</name>
        <name evidence="2" type="ORF">LdCL_190018100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860305.1">
        <property type="nucleotide sequence ID" value="XM_003860257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEC2"/>
    <dbReference type="GeneID" id="13386117"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1570"/>
    <dbReference type="OMA" id="EWIATEV"/>
    <dbReference type="OrthoDB" id="265073at2759"/>
    <dbReference type="PhylomeDB" id="E9BEC2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="976" mass="103876" checksum="B1D9E9E48ED7859C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGX5</accession>
    <accession>A0A3S7WYA1</accession>
    <name>E9BGX5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_241120</name>
        <name evidence="11" type="ORF">LdCL_240016200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861203.1">
        <property type="nucleotide sequence ID" value="XM_003861155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGX5"/>
    <dbReference type="GeneID" id="13390888"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1300"/>
    <dbReference type="OMA" id="NAPCYEI"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="PhylomeDB" id="E9BGX5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001369">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="386"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="575"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119263" checksum="2D2874275FFEB956" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIW0</accession>
    <accession>A0A3Q8IDY8</accession>
    <name>E9BIW0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Flap endonuclease 1</fullName>
            <shortName evidence="16">FEN-1</shortName>
            <ecNumber evidence="16">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LDBPK_270260</name>
        <name evidence="19" type="ORF">LdCL_270007400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19 22" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 22">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
            <location evidence="16">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="16">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="16"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861883.1">
        <property type="nucleotide sequence ID" value="XM_003861835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIW0"/>
    <dbReference type="SMR" id="E9BIW0"/>
    <dbReference type="GeneID" id="13389144"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0340"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="PhylomeDB" id="E9BIW0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 16 20" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU79904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBZ35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="395" mass="44201" checksum="048F3533F151EA65" modified="2011-04-05" version="1">MGILGLSKLLYDKSPNAIREQELKNFFGRRIAIDASMSIYQFIIAMKGFQDGQGLELTNEKGDVTSHLNGLFARTLRMIDEGIKPIYVFDGKPPKLKADELEMRRQKAAEAEREFEKAKDAGDDEMMEKMSKRTVRVSRDQIDESKKLLRLMGIPVIQAPSEAEAQCAELVKKGKAWAVGTEDMDALTFGSTVMLRHLNISDAKKRPIAEIHLDEVLQITGLSMGQFVDLCILLGCDYVPKVPGIGPQKAWEGIQRYGSIESFLESLDTTKHPVPADFYYKEARAFFQNPEVTPAEEINIQFSEPDEVGLIQFLVKEKLFNPDRVNKGIARLRAALTRKTQGRLDSFFTVTKVPQQTAAARAPLAGTKRPRDGKYVHVSGTLRKATSGHKKAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLE2</accession>
    <accession>A0A3S7X313</accession>
    <name>E9BLE2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_300480</name>
        <name evidence="2" type="ORF">LdCL_300009900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862762.1">
        <property type="nucleotide sequence ID" value="XM_003862714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLE2"/>
    <dbReference type="GeneID" id="13385469"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0660"/>
    <dbReference type="OMA" id="NIESNGM"/>
    <dbReference type="OrthoDB" id="271594at2759"/>
    <dbReference type="PhylomeDB" id="E9BLE2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="548" mass="60428" checksum="D2E8631BDE62974B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNI9</accession>
    <accession>A0A3S5H7R5</accession>
    <name>E9BNI9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_320850</name>
        <name evidence="1" type="ORF">LdCL_320014000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863502.1">
        <property type="nucleotide sequence ID" value="XM_003863454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNI9"/>
    <dbReference type="GeneID" id="13390315"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1060"/>
    <dbReference type="OMA" id="LVWQEDH"/>
    <dbReference type="OrthoDB" id="273330at2759"/>
    <dbReference type="PhylomeDB" id="E9BNI9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125452" checksum="73072C9A0C0E0AC8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNR7</accession>
    <accession>A0A3S7X5I2</accession>
    <name>E9BNR7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF3 subunit 135, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_321640</name>
        <name evidence="3" type="ORF">LdCL_320022000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863580.1">
        <property type="nucleotide sequence ID" value="XM_003863532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNR7"/>
    <dbReference type="GeneID" id="13390630"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2070"/>
    <dbReference type="OMA" id="WWISTRC"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="PhylomeDB" id="E9BNR7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="2">
        <location>
            <begin position="205"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="918" mass="99263" checksum="0B94A00293F5370C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPW4</accession>
    <accession>A0A3S7X6B0</accession>
    <name>E9BPW4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12 23">Heat shock protein 83-1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Heat_shock_protein_83-17/GeneDB:LmjF.33.0365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LDBPK_330360</name>
        <name evidence="24" type="ORF">LDBPK_330370</name>
        <name evidence="12" type="ORF">LdCL_330008800</name>
        <name evidence="13" type="ORF">LdCL_330008900</name>
        <name evidence="14" type="ORF">LDHU3_33.0460</name>
        <name evidence="15" type="ORF">LDHU3_33.0480</name>
        <name evidence="16" type="ORF">LDHU3_33.0500</name>
        <name evidence="17" type="ORF">LDHU3_33.0520</name>
        <name evidence="18" type="ORF">LDHU3_33.0530</name>
        <name evidence="19" type="ORF">LDHU3_33.0540</name>
        <name evidence="20" type="ORF">LDHU3_33.0550</name>
        <name evidence="21" type="ORF">LDHU3_33.0560</name>
        <name evidence="22" type="ORF">LDHU3_33.0570</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="23 25" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 26" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 26">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863859.1">
        <property type="nucleotide sequence ID" value="XM_003863811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPW4"/>
    <dbReference type="SMR" id="E9BPW4"/>
    <dbReference type="GeneID" id="13392256"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330360"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0570"/>
    <dbReference type="OMA" id="TRMKAEQ"/>
    <dbReference type="OrthoDB" id="276124at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5433213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5433214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5433215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAC5433216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAC5433217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAC5433218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAC5433219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAC5433220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAC5433221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CBZ37176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CBZ37177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="700" mass="80551" checksum="576703C6646170E9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR91</accession>
    <accession>A0A3S7X898</accession>
    <name>E9BR91_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_342930</name>
        <name evidence="3" type="ORF">LdCL_340038100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864452.1">
        <property type="nucleotide sequence ID" value="XM_003864404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR91"/>
    <dbReference type="GeneID" id="13392861"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340038100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5050"/>
    <dbReference type="OMA" id="YYCSPRA"/>
    <dbReference type="OrthoDB" id="272452at2759"/>
    <dbReference type="PhylomeDB" id="E9BR91"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="425" mass="46809" checksum="543DB559F7BA4AE1" modified="2011-04-05" version="1">MEFVSASSPVQRRPVGVPPYRVPPLSGLYRMRYHPPTQDSTSSDRLRAESGVEGSGDAVSGTRTACRATTGPPAQAGANSAAARHAAVHQQLLRASSLLDDGIDLFALYSLCEVESVPCKLCTLHTQATLNTCSYRLRQSYELQKRGTDPSLHYLTRVTETRDEAAARSATESSPLIRILQQGWYVFFFPMSECGRLKDNLLVYVGEALIAGDVAECDLANDGCLRPLKTTTAVALPGAVNGPLGGTTTAGASKSTSANPQYWKSLFYYVVSPVPVHWGTRQSADVHLTILWRSIPAAYPEHRQRKKSVTLLYSYYCSPRAPDTFTCRAHFPSHTRLRLVRSPNCDTKVQLRSDVTEHMAKVHVETMDGKPLETHRHTRDYVFVLQFLLGDDTGILEESGVFAAAVVAIVFLLLLWLLLTKDLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRS5</accession>
    <accession>A0A3S5H7Y4</accession>
    <name>E9BRS5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin (Or S-antigen), N-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_350430</name>
        <name evidence="3" type="ORF">LdCL_350009400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864636.1">
        <property type="nucleotide sequence ID" value="XM_003864588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRS5"/>
    <dbReference type="GeneID" id="13387514"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0590"/>
    <dbReference type="OMA" id="WDDQGEF"/>
    <dbReference type="OrthoDB" id="271065at2759"/>
    <dbReference type="PhylomeDB" id="E9BRS5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="637" mass="69738" checksum="F35811ED6AC3B5CD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUS9</accession>
    <accession>A0A3Q8IJZ7</accession>
    <name>E9BUS9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_365720</name>
        <name evidence="2" type="ORF">LdCL_360064600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865685.1">
        <property type="nucleotide sequence ID" value="XM_003865637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUS9"/>
    <dbReference type="GeneID" id="13388571"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360064600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7600"/>
    <dbReference type="OMA" id="PGIYWAN"/>
    <dbReference type="OrthoDB" id="266118at2759"/>
    <dbReference type="PhylomeDB" id="E9BUS9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="668" mass="71794" checksum="17B0ACEB4CB2F6B3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I866</accession>
    <accession>E9BB28</accession>
    <name>A0A3Q8I866_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_27540</name>
        <name evidence="7" type="ORF">LDBPK_120480</name>
        <name evidence="6" type="ORF">LdCL_120010500</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000046">
        <property type="protein sequence ID" value="TPP53929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859165.1">
        <property type="nucleotide sequence ID" value="XM_003859117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I866"/>
    <dbReference type="GeneID" id="13390126"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0740"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP53929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="137" mass="15263" checksum="B5A84F28E540BD7C" modified="2019-04-10" version="1">MANSVRYRNGEQRIVGIIGDEDTVTGFLLAGVGDNRVMPNQRENPGEGQQSGLQPNYYVVTPSTPLSEIEEAFTTMCGRKDIGIIIICQHIANDIRHLVEEYNTVIPCILEIPSKGQKYDAEKDFVLEKITRALGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9F4</accession>
    <accession>E9BBA2</accession>
    <name>A0A3Q8I9F4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alba family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Alba, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Alba_putative/Pfam:PF01918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_17395</name>
        <name evidence="5" type="ORF">CGC21_33130</name>
        <name evidence="4" type="ORF">LDBPK_130270</name>
        <name evidence="2" type="ORF">LdCL_130008800</name>
        <name evidence="3" type="ORF">LDHU3_13.0480</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859239.1">
        <property type="nucleotide sequence ID" value="XM_003859191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9F4"/>
    <dbReference type="GeneID" id="13391063"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0480"/>
    <dbReference type="OMA" id="YVDYTKH"/>
    <dbReference type="OrthoDB" id="1699369at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.20:FF:000005">
        <property type="entry name" value="Uncharacterized protein At2g34160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014560">
        <property type="entry name" value="UCP030333_Alba"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31947">
        <property type="entry name" value="DNA/RNA-BINDING PROTEIN ALBA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31947:SF36">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN ALBA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030333">
        <property type="entry name" value="UCP030333_Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="121" mass="13360" checksum="703641A6EE9182BA" modified="2019-04-10" version="1">MSAENGGNAIVRVSSNKRKFGYVDYTKHRLHEGYPEVVISALGTAIADAVSVVELLKNQGVVEVKKICTSRAQFDDVRSTTTDKIEVVVVKSPDFDAIYDQQQKDREIAKARAEADEADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9K5</accession>
    <name>A0A3Q8I9K5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex1 LYR-like/Complex 1 protein (LYR family), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Complex1_LYR-like/Complex_1_protein_(LYR_family)_ putative/Pfam:PF13232/Pfam:PF05347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130017500</name>
        <name evidence="3" type="ORF">LDHU3_13.1480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9K5"/>
    <dbReference type="SMR" id="A0A3Q8I9K5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1480"/>
    <dbReference type="OrthoDB" id="268984at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13232">
        <property type="entry name" value="Complex1_LYR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="196" mass="23377" checksum="A1F976819E669D77" modified="2019-04-10" version="1">MLRTSLVARRTAAEATGAPVSYRHQEKIRLYRSLLKGAHGFPMRSRRDVITEEVRSTFRDPNNEMLSEKDIDYRLILGWERAKSIKTYAENMHWFHSRDEVTKEMMYFSEERDRKKAAEMRRFNQVGDIRCKTEEVTEFKSTYYNVHPDYHSKIGQKPLTHSRDVWRARGQYGSDVGGPRQKFFVRRFKAMFPQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB05</accession>
    <name>A0A3Q8IB05_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_39395</name>
        <name evidence="4" type="ORF">LdCL_180012100</name>
        <name evidence="5" type="ORF">LDHU3_18.0930</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB05"/>
    <dbReference type="SMR" id="A0A3Q8IB05"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0930"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5429286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="454" mass="50401" checksum="5E2463BEE05332F4" modified="2019-04-10" version="1">MASSVLDEMKEQMLRRCREDQKKIDDLRKKHGHEKLCDATIDAVYGGMRGITGLVYEPSLLDSAEGIRFRGLTILECQEMLPKAPGGKEPLPEAMFWLLMTGEVPTEEQARGLNAELHRRVDPEAIAAAQKAIAALPKNAHPMTAFSVGVLALQTYSKFAAAYAAGKSNKKTYWEYALEDSLDMLARTPAVVAMIYNRETKGQVELAAPSNSDLDWAANFANMLGFHDEEFRECMRLYLSVHADHEGGNVSAHTTTLVASALSDPYLAFSAGLNGLAGPLHGLANQEVLNYLLSMQERVKADGVNVHDEAALEKALTKYTWELLNSGQVVPGYGHAVLRKVDPRYTCLRNFCLRHNFQDDLFKLVNTIYMIMPGILKEHGKTKNPYPNVDAHSGVLLQHYGLTDQNCYPVLFGLSRQMGVLAGVVWDRLQGRPLERPKSTTTEMLAKKYLCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBN6</accession>
    <accession>E9BL53</accession>
    <name>A0A3Q8IBN6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 20, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Heat_shock_protein_20_putative/GeneDB:LmjF.29.245 0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_292560</name>
        <name evidence="5" type="ORF">LdCL_290031700</name>
        <name evidence="6" type="ORF">LDHU3_29.3810</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862674.1">
        <property type="nucleotide sequence ID" value="XM_003862626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBN6"/>
    <dbReference type="SMR" id="A0A3Q8IBN6"/>
    <dbReference type="GeneID" id="13385377"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290031700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3810"/>
    <dbReference type="OMA" id="TGRFERC"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000096">
        <property type="entry name" value="Heat shock protein 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5431973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17519" checksum="DB795552D68DE150" modified="2019-04-10" version="1">MWSPSNKRDSLINSDDALFPFLLHFPGLHPRQMFSSFFSSRSRGSWIPAVDISEQDDGYTLVADLPEVRKEDLRVYTESSSIICISGNRKHILKQDEHQLLVAERGAGRFERCFDLPTSVDSSKIKASFNDQQLNVSIPKLRNSRSGTSNTVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBS0</accession>
    <name>A0A3Q8IBS0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidohydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Amidohydrolase, putative</fullName>
            <ecNumber evidence="5">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_29010</name>
        <name evidence="5" type="ORF">LdCL_200022100</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBS0"/>
    <dbReference type="SMR" id="A0A3Q8IBS0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2110"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08021">
        <property type="entry name" value="M20_Acy1_YhaA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="401" mass="43557" checksum="2687BCCD172061F1" modified="2019-04-10" version="1">MSFVQTLITAVQPEVVQWRRHIHEYPYVAYEEQPTADYVADVLSSMPAPLDIRRLTPNSVVADLRGGAGEGPMYALRADMDALPLQEESGEPFSSKRPGVMHACGHDAHTAMLLGAVKVLCQMRDRIRGTVRFVFQHAEEVVPSGAKQLVGLGVLDGVSMIFGLHVDVMRPSGSIWCRMGTIMGACNDFDIVIRGAGGHASQPELCVDPILIASEVVANLQSVVSRRVSALKAPVLSITTFEGGRGSYNVIPDTVRMRGTLRCLDRDTQARVPSLMEEIIAGITKAHGAQYELSWLEPNIVTYNDPKAYEVAKAAAVRLVGEGNYHELSTPLLGVADFSEYQAVVPGCLCWLGVGNSALGDANNHNYSSRFRMNEAGMELGVKHHVLIIASLMMQTEGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICB4</accession>
    <name>A0A3Q8ICB4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_260026100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICB4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2680"/>
    <dbReference type="OrthoDB" id="266588at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018598406" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1018" mass="109023" checksum="AC862EC2D9DA0CDD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICJ1</accession>
    <name>A0A3Q8ICJ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310020600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICJ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2240"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="517" mass="52785" checksum="8C1CDAFA88D9D085" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID61</accession>
    <name>A0A3Q8ID61_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2C-like protein</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_140015200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID61"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1210"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF541">
        <property type="entry name" value="PHOSPHATASE 2C, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="434"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="851" mass="90661" checksum="46512AA36F4269B3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID88</accession>
    <accession>E9BC28</accession>
    <name>A0A3Q8ID88_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_5135</name>
        <name evidence="12" type="ORF">LDBPK_141460</name>
        <name evidence="11" type="ORF">LdCL_140020400</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="Biochimie" volume="138" first="124" last="136">
            <title>Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.</title>
            <authorList>
                <person name="Barros-Alvarez X."/>
                <person name="Kerchner K.M."/>
                <person name="Koh C.Y."/>
                <person name="Turley S."/>
                <person name="Pardon E."/>
                <person name="Steyaert J."/>
                <person name="Ranade R.M."/>
                <person name="Gillespie J.R."/>
                <person name="Zhang Z."/>
                <person name="Verlinde C.L.M.J."/>
                <person name="Fan E."/>
                <person name="Buckner F.S."/>
                <person name="Hol W.G.J."/>
            </authorList>
            <dbReference type="PubMed" id="28427904"/>
            <dbReference type="DOI" id="10.1016/j.biochi.2017.04.006"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS)</scope>
    </reference>
    <reference evidence="11 15" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859512.1">
        <property type="nucleotide sequence ID" value="XM_003859464.1"/>
    </dbReference>
    <dbReference type="PDB" id="5USF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.75 A"/>
        <property type="chains" value="A/B=1-682"/>
    </dbReference>
    <dbReference type="PDBsum" id="5USF"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID88"/>
    <dbReference type="SMR" id="A0A3Q8ID88"/>
    <dbReference type="GeneID" id="13392880"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1820"/>
    <dbReference type="OMA" id="TIMGKTE"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="BRENDA" id="6.1.1.1">
        <property type="organism ID" value="2947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP46328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5USF"/>
        </source>
    </evidence>
    <sequence length="682" mass="74938" checksum="1025492B9FD6229F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDM3</accession>
    <name>A0A3Q8IDM3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_290017000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDM3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1640"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000546">
        <property type="entry name" value="Ankyrin repeats (Many copies)/Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="360" mass="40018" checksum="BA1AB06F6D51E8F6" modified="2019-04-10" version="1">MTDFPKLNRIKSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQNRFGCTALHLACKFGCVDTAKYLASVGEVHSSWHGQKPIHLAVMANKTDLVVALVEGAKERGQMPESLLNECDEREVNEIGSHVKHCKGQTALHWCVGLGPEYLEMIKLLVQLGASPTAKDKADETPLMRAMEFRNREALDLMMDTVPSKSSLHLDYADKQGNSHLHWAILINWEDVAMRFVELGIDVNMEDNEHTVPLYLSVRAAMVLLTKELVQKTDVFLIQTCPYHNGTTVLPDRVVWLDFVPAAANPSKQEVLQLLQEKLDEVVRSLSSGAGGAVKRKKKAAPAVKRMKLAPSAPVRTRSRSRARSSAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDV0</accession>
    <name>A0A3Q8IDV0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330027400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDV0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2970"/>
    <dbReference type="OrthoDB" id="249280at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="73190" checksum="4025BC3E0C5A9666" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEH9</accession>
    <accession>E9BE71</accession>
    <name>A0A3Q8IEH9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane transport family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Transporter, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transporter_putative/GeneDB:LmjF.19.0760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_8945</name>
        <name evidence="11" type="ORF">CGC21_19210</name>
        <name evidence="9" type="ORF">LDBPK_190760</name>
        <name evidence="7" type="ORF">LdCL_190012600</name>
        <name evidence="8" type="ORF">LDHU3_19.0840</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860254.1">
        <property type="nucleotide sequence ID" value="XM_003860206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEH9"/>
    <dbReference type="GeneID" id="13386066"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0840"/>
    <dbReference type="OMA" id="FANLCVN"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039305">
        <property type="entry name" value="PILS2/6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31419">
        <property type="entry name" value="PROTEIN PIN-LIKES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31419:SF1">
        <property type="entry name" value="PROTEIN PIN-LIKES 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="491" mass="53630" checksum="5A0EA250FC6AA284" modified="2019-04-10" version="1">MGDLYLGMMLITATTVGKIILCALAGMLVSRYFSNPKETLTGLSYISARVFLPCLLFANLSMNVTWEQLSKFYWAPLFALLPMGIGFLSSMLVRAVLRREYHFVVILASSFQNGLTFPVSVLLNLKGIEWFTGAAVVDAQSYIFLYNVVCSIGLWALGDPMIAYAKTKEVESEEANDEELVARRRPYSMDGRVDGEAEGKEKAQSSPHTAAAAQQGHATAHEQLEWYRPAQASDKPIMLPPGSPGILLDDEMRITNSKLKPRDDRLKRLGRIALTSIQSPTVLSSIIALIISLTPPLQRLAKSPFGEPFVGGMALVGKGAIPLHLVVLGSSVAASRPKAHPTSSAKRAQVTISSPTTSAPLPTSADGTVFDVSASQPGTGVNALRYWITSRVQPQILFTCCAVVTRLVIIPCICFLALHILVKAGLMPSEKPFLLSMLVAIISPTAINSTLICTMREYHVRDYSHMMFFMYLSSIITSSVWLFCILLYLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFA3</accession>
    <accession>E9BQM1</accession>
    <name>A0A3Q8IFA3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">JAB1/Mov34/MPN/PAD-1 ubiquitin protease family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Proteasome regulatory non-ATP-ase subunit 11, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Proteasome regulatory non-ATPase subunit 11, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Proteasome_regulatory_non-ATPase_subunit_11_putat ive/GeneDB:LmjF.34.0650</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_2185</name>
        <name evidence="10" type="ORF">CGC21_25695</name>
        <name evidence="9" type="ORF">LDBPK_340670</name>
        <name evidence="7" type="ORF">LdCL_340012300</name>
        <name evidence="8" type="ORF">LDHU3_34.1110</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864232.1">
        <property type="nucleotide sequence ID" value="XM_003864184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFA3"/>
    <dbReference type="SMR" id="A0A3Q8IFA3"/>
    <dbReference type="MEROPS" id="M67.A11"/>
    <dbReference type="GeneID" id="13392641"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1110"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="527244at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5433629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="309" mass="34710" checksum="6631FBEF939337E7" modified="2019-04-10" version="1">MDPSAFGMMAGRGMGRQTEVRDARDTAETIQISSIALLKMLIHGRAGVPLEVMGLMIGEEIDDYTIRVADVFSMPQTATGQSVEAVDPEYQVHMLDKLKLVGRHENVVGWYHSHPGFGCWLSSEDVMTAAGYENLTPRSVSVVVDPIQSVRGKVVIDAFRTIPQEIMAMRAMGEYVEPRQVTSNIGFLSKPSAVALSHNLNRQYYNLPVTFRKKNHELRLLLNVYRKGWQEGFKLEKAKVYQRETRTSIRELISLSKQAEKYITQGRDEDDLGNVGQINAMSHLQMEAENVIHRNLNQSIGAMINAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFC2</accession>
    <name>A0A3Q8IFC2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Surface antigen protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_310021700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFC2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2540"/>
    <dbReference type="OrthoDB" id="266298at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018669311" description="Surface antigen protein 2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="45987" checksum="115321CB8AC81C05" modified="2019-04-10" version="1">MLRRLACAFLTAALGVFFVLLGSDAAMAHAAEDMPLSLQIEKARFSDAEPRYSFTTVQKLNTLKILQAFAEAIPSLGWAGTDFCKWPSVTCYQSTVLFTVSGISVKGTLPDLPDAVDYSHVMITTINLFNQKSSISGTLPSSWGKLQHLVTLNMGSTSVSGTLPASWGSLRAVTFISLPKTSISGSLPASWRSMSSLATLILYDTQLSGTLPPEWSSMASMGILQLHQNQFTGSLPASWAQMPALRRLSLIANNFCGCVPDSWRRASFRVTVDSQNSAANCATANSCDPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPTTTTTEAPSECEVPHCITCVRGNPTRCDVCASGYMVTAAQWCMKRPSADLASSPSSTALNAATSLGVLAAVLLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFE4</accession>
    <accession>E9BSP8</accession>
    <name>A0A3Q8IFE4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_7325</name>
        <name evidence="4" type="ORF">LDBPK_353770</name>
        <name evidence="3" type="ORF">LdCL_350042700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864957.1">
        <property type="nucleotide sequence ID" value="XM_003864909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFE4"/>
    <dbReference type="GeneID" id="13387834"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350042700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4930"/>
    <dbReference type="OMA" id="NDCRVRE"/>
    <dbReference type="OrthoDB" id="270350at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="440" mass="50651" checksum="2BB9F81DBCA151B2" modified="2019-04-10" version="1">MELATMDPVAQQELQRMTRAIEEYAARLDSLGAELETIEQQNRNDEVSRQIQQYNEATVAPQEIAAEDAMDNIVRLQNQLKIVQRRNQLLARENAMQEKLLRERANKLHSTHKELDMVMAATGWYGGKRDVQFSRIERERADIHDMSLVEASLRADIKSSKVTIARLEKTVLALSAKVLENEERRTRYMQLCNDCRVREKECNELQAKAQRMAADNNKLQLVVKTESDSTLVENSIACMESDREFLSDAVQDMKMACRRQENVIKAQLTREQQLQRRLDTVTKSLNEMRLAREFERNVAKSALVPSASREEPEDVSEVLPQDEYIPVDTFRLLYKNNEMMRTNVARKNMLVLEKESVVQSMEARLMQHVEKHNEVARFDDSIHISGEASVRAAKRNLDAEENKLVRQIEELRASNNQMRAAIAKKAAPTQARKAASGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFG7</accession>
    <accession>E9BLD2</accession>
    <name>A0A3Q8IFG7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase 2C, putative</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 2C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_35005</name>
        <name evidence="3" type="ORF">LDBPK_300380</name>
        <name evidence="2" type="ORF">LdCL_300008900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862752.1">
        <property type="nucleotide sequence ID" value="XM_003862704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFG7"/>
    <dbReference type="GeneID" id="13385459"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0530"/>
    <dbReference type="OMA" id="IDDQEAC"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000073">
        <property type="entry name" value="Putative phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="384" mass="41716" checksum="588598024D4C2277" modified="2019-04-10" version="1">MGLMLPKPILSKVVDRAGNSFVNAACASQNGFRNSMEDAHMLVATDDADVAYFGIFDGHSNAECSAYVARELPQRLKKLPETITAEMLEKVCIEVDEAYMKANTEGGTTGTFCVIRKDLTVTIANVGDSRILVCRGGKLIFATEDHKPYIPGETERIVACGGSVVSNRVDGDLAVSRAFGDASFKVKGTKDYRMQKVIAVPDVSVLQCEPNDFVILACDGVFEGNFSNEDVCQFVWEQQQNCWDDLAVVACRVCDEAIRCGSKDNISCLVVQLAEGASKVKLFGATSFVPGPPFPRNQQPCRAAYAQMAELGHTTTAAALQTRYQLLQAFSKNKLNSQPPVMRTAFEMSDEVDVETEWSFFGKGPAPGNEKSFFEALANTGNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFI0</accession>
    <accession>E9BNV5</accession>
    <name>A0A3Q8IFI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B6 photo-protection and homoeostasis, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Vitamin_B6_photo-protection_and_homoeostasis_puta tive/Pfam:PF04884</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_322030</name>
        <name evidence="8" type="ORF">LdCL_320025700</name>
        <name evidence="9" type="ORF">LDHU3_32.2520</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863618.1">
        <property type="nucleotide sequence ID" value="XM_003863570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFI0"/>
    <dbReference type="GeneID" id="13390905"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2520"/>
    <dbReference type="OMA" id="LAMWKPA"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5432957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="468" mass="53269" checksum="AF735818680FAA00" modified="2019-04-10" version="1">MTDYRWCAIPGTDTVCAPSVQHRETVSNRIRLFGMPKGFPDTTAAGFQRFFYLSLTSSFVSNFASSIGYQSLLSGFFLGSSPQLWMLKDLVPALFAAYMANKVVSYESRPKFWFVVSVFINNLTVISDMLIPSVLPNHLLAAAIITSTVKQSSALMYFVTRASALQHYAINNNLAELTKKFNSFGMVSYTVATALGILYCTYIASFTVQLITVAACCVTNMFLSSMSMMPITFRLLNFDTMKLLLRAFILEKRRILTPQEISNLLGVRMLPMQALKKVGIAMDVATHLVCVSPPVNKLLIRSDTLEEDVLYVNSDHMFMLAMWKPSPLPLTLRECWQRYEFPPLPRLFRKASWRRRSQEDLDMEKKFHGRRLVLLVHQKCTAKHLIAAYLIMYTAVLQHADTEEELRRFVRTCHGEQELWHLRGEEFGQMLLAADWDVHLPLLDHHNFRMSELILPPSMRSAAKGCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGT5</accession>
    <accession>E9BV28</accession>
    <name>A0A3Q8IGT5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_15665</name>
        <name evidence="3" type="ORF">LDBPK_366720</name>
        <name evidence="2" type="ORF">LdCL_360075500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865783.1">
        <property type="nucleotide sequence ID" value="XM_003865735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGT5"/>
    <dbReference type="GeneID" id="13386637"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360075500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8930"/>
    <dbReference type="OMA" id="QHAKEQW"/>
    <dbReference type="OrthoDB" id="263777at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="308" mass="32685" checksum="A063D003A2EC3278" modified="2019-04-10" version="1">MNREQIARRIDLVGPSTGAIVGVATWCALHGAEADAILNYVAEKMKHKDTTDAQRASLVYVIHELLLSCATRGVSENAKRSILKAVSLTLPSAVKDTLRQRASDHTAFLIALQKATEWWSMLNLFPAAWLTKLQCTVQDGQESAGHRTSVPSALMQVANLLQRYQHAKEQWVQNRNIKAEEGRSGSGAASGQDTAAPLAGGGAGASSAVVDDAARRCLIALRKAVESRFEKNAALLAWCEAERAELEGRTTTSSAGSGVVKMAHGTSPHVPTHGRSGSSYPVKEEGGHGGSQSGGPNDDDDVLGSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGV9</accession>
    <accession>E9BJV2</accession>
    <name>A0A3Q8IGV9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_12985</name>
        <name evidence="5" type="ORF">CGC21_22590</name>
        <name evidence="3" type="ORF">LDBPK_282310</name>
        <name evidence="2" type="ORF">LdCL_280028200</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862330.1">
        <property type="nucleotide sequence ID" value="XM_003862282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGV9"/>
    <dbReference type="SMR" id="A0A3Q8IGV9"/>
    <dbReference type="GeneID" id="13387066"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3140"/>
    <dbReference type="OMA" id="LTAGWYK"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="243" mass="27505" checksum="69FC9810CC22F1AD" modified="2019-04-10" version="1">MVPRQYRPKANMLALVSDQVKSLRSLVYDTCIVPMTSRWYREVLLECPTNSVMLDIGIGTAASLIANRDIIVSKKMTVTGVDYDLAYVRSAQMNVAACGGRLQDLVRIEQADIHDYNKSHTKKFDILYFSGSFMIIPSQVGALRHCVQMLRSPVPQVPGGCNIFFTQTFERRTFIGQYVTPLVKRVLKVITTIDFGEVTYEDEFRAALEEADVEIVGVKPIHASYYRTQALVMARPRVTMEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II36</accession>
    <name>A0A3Q8II36_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_5590</name>
        <name evidence="2" type="ORF">LdCL_330040300</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000051">
        <property type="protein sequence ID" value="TPP42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II36"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330040300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4750"/>
    <dbReference type="OrthoDB" id="263698at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1017" mass="109258" checksum="0894AD62C576821A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II43</accession>
    <name>A0A3Q8II43_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_130018500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II43"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1580"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="658" mass="70694" checksum="AB19154159611A61" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIK0</accession>
    <name>A0A3Q8IIK0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_290009300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIK0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0620"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="379" mass="41221" checksum="44CA1AF74EAF23AC" modified="2019-04-10" version="1">MASPRKVDLFVARAYSRKGVQSGLFFWIVLALVFAGTFVVSKIPLGLYTPTVGFQQGKHREPPKQSIPPTPTTPAGRGIIRAYNQRIIAIGDLHGDIDRLRSTLRAANVLEKDADAWRKGCNDVVVQLGNVVGYGPDVPEMLQLLSELKPQALASGGRLITLSGSQELLTLSGVLEYVHPRLLNLSAGYVGVRYLYGPGGRYGRMMAEENLAVVIVSDIVFVHGGLTAAYARRGVDQLNAEWYEGAALNLTRHPFHDEESPLWDHSVVRAAMGGNCGPLSAGMAALKAKENRDINLMVVGHTAMQDGKVGTWCAGKLMTIDVAMSRYVENGGYEAFVSFLPMLKKVKRKKLVRSTAERVQTHYPLGPGVRATLLTPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ00</accession>
    <accession>E9BTA9</accession>
    <name>A0A3Q8IJ00_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dihydrouridine synthase (Dus) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Dihydrouridine synthase domain protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Dihydrouridine_synthase_domain_protein-like_prote in/GeneDB:LmjF.36.0470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_29665</name>
        <name evidence="11" type="ORF">CGC21_12580</name>
        <name evidence="9" type="ORF">LDBPK_360500</name>
        <name evidence="7" type="ORF">LdCL_360009900</name>
        <name evidence="8" type="ORF">LDHU3_36.0650</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865166.1">
        <property type="nucleotide sequence ID" value="XM_003865118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ00"/>
    <dbReference type="SMR" id="A0A3Q8IJ00"/>
    <dbReference type="GeneID" id="13388052"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0650"/>
    <dbReference type="OMA" id="EDGEQAH"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP48166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="439" mass="47929" checksum="0AC577D97210C4AA" modified="2019-04-10" version="1">MKVEESMFYHKTILAPMVRVCSPGFRALCGAHGADVVFTEEVVAAKLATCQREVVHYPTVDTPMAEYVSYDPFKNTYKRTVVLSTPVLPDITCGGHKAERIAAPRIVLQLGVADPARGAAAALVCSNDIDGIDINMGCPKKFSVHNGFGAALMKRPEVGGAIVRAVHDAVNSDSNVEARGGKRVAMSLKTRLQDTAEATVGMLRAILAAAQHTPTNPILHAITIHARTPDQRSEQAPLYDRAAEVVRTCRADAAFEGICLVLNGSVLSRQDGEAKCALYGFDAAMIARAALEDARCFHRKGSELRFSSAAHDSEAQSTEDAEVYAMAIMKELFFYSVRYRTLFNNFKYHLTRAFPMVKALKPFMEEVQVELRSYADCYEFFRLTVEEKALADSCAHTVELLVEKSASTRKRAAVTAAASEEVGAQEHKLARVETTKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKD2</accession>
    <name>A0A3Q8IKD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360018400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKD2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360018400"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13451" checksum="80944CD9EA8E292C" modified="2019-04-10" version="1">MEILSLPSLRAYTYTSIYIDIYIYIYIYIYLRVTGGIAACAQGLFAGSPFFLFPSSFSFFSTVHCGDVSRRTSRQARACTHAHAHTRKRKETKLGFSSIYLSVYPQKQKNETQQQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMZ0</accession>
    <name>A0A3Q8IMZ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycan beta 1,2 arabinosyltransferase, (SCA like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340010900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMZ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0900"/>
    <dbReference type="OrthoDB" id="262657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="901" mass="100439" checksum="593D1D871CC23171" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ING8</accession>
    <name>A0A3Q8ING8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase delta subunit 2, putative</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_250020100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ING8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1790"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000012">
        <property type="entry name" value="DNA polymerase delta subunit 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="267"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="433"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="590" mass="64141" checksum="DB93288F4834A305" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQ17</accession>
    <accession>E9BJ93</accession>
    <name>A0A3Q8IQ17_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_32520</name>
        <name evidence="13" type="ORF">CGC21_30610</name>
        <name evidence="11" type="ORF">LDBPK_271610</name>
        <name evidence="9" type="ORF">LdCL_270023200</name>
        <name evidence="10" type="ORF">LDHU3_27.2470</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862014.1">
        <property type="nucleotide sequence ID" value="XM_003861966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQ17"/>
    <dbReference type="SMR" id="A0A3Q8IQ17"/>
    <dbReference type="GeneID" id="13386748"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2470"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5431288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP47480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="453" mass="50841" checksum="EB3A20C86005063F" modified="2019-04-10" version="1">MSGEKELTDAEKTIERYKVKKLIQMLESARGMGTSVISVYMTPKEQIAGMVAKLNNEYGTASNIKSHTNKLSVQSAITAALGRLKQIPRVPANGLLLYSGTVMTADNKEKKLTLDIEPFKAVSRSLYLCDNKFHTEELRRMLESDDKFGFIIMDGSGSTFATVCGDVKEKLGSFTVELPKKHGRGGQSKNRFARIRMERRHNYVRKVAETAVSYFITNDRPNVRGLVLAGSADFKEVLFQSDLFDPRLKEVVVKIVDVAHPGDVGLNQAIDLSADALSGVKLVQEKKLLQTFFDQIAMDTQQYCFGVNDTMRCLEAGAVETLICFEDLQVNRYVIIKNKGAEDEATEIHLLTEAEANKKNIHAHEAGKTQNEIESENFVDWLAQNYQKFGCTLELISDRSQEGTQLVRGFGGIGGILRYKMDVMALRDHEKKEEDDDRIAANNEEFDFDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQT2</accession>
    <name>A0A3Q8IQT2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_280030000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQT2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280030000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3370"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10194" checksum="1D51D2F3CF766533" modified="2019-04-10" version="1">MRPLRTASNYCAWDGVTCNSKSYAHVSSSGHMLVDEMPKVDGSDYGALPRVALIVLSNNSRIHGGLADSLTAPKRLRSLEVSRKSVHWNLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISA0</accession>
    <accession>E9BM96</accession>
    <name>A0A3Q8ISA0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_303530</name>
        <name evidence="7" type="ORF">LdCL_300040900</name>
        <name evidence="8" type="ORF">LDHU3_30.4690</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863064.1">
        <property type="nucleotide sequence ID" value="XM_003863016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISA0"/>
    <dbReference type="SMR" id="A0A3Q8ISA0"/>
    <dbReference type="GeneID" id="13385773"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4690"/>
    <dbReference type="OMA" id="HIPFKWG"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001835">
        <property type="entry name" value="Casein kinase 1 isoform 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5432377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="376" mass="42200" checksum="582C5245E9268F4D" modified="2019-04-10" version="1">MGTRSKRAQDVLIGGRFRIQERLGGGAFGEVFRGVELNSGHPVAMKMELTKDGHRSHLNLENRIYKKFNECPVTVGIPKSYYCGRVGDYTVMVMDLLGPCLDDLFEVCHRKFSFKTVCMIGIQLIQRLQYLHSVGYLHRDIKPENFVMGVGANSHIVYVIDVGLSKAWRDSTGKHILYAEGKSLTGTARYVSINTHRGIQQSRRDDLESVSYLLAYFARGNLPWQGLKSPKRDARFERIRDVKTATSPAELCKGYPRQLADYIEYTRSLGFEAEPDYSYCVGLFSSAMADMGEQYDYCYQWIDRSEAEVKAASDARGSAHSLRTSGAQTSVAVGGSNLMTSSVFVGDSAVNEMSKSLLNSNFMEEIQDYYGLNDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVD1</accession>
    <name>A0A3Q8IVD1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350036100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVD1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350036100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4050"/>
    <dbReference type="OrthoDB" id="278120at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17186">
        <property type="entry name" value="Lipocalin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="822" mass="92092" checksum="EF5BE98C602E459F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F0</accession>
    <accession>E9B880</accession>
    <name>A0A3S5H5F0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_2990</name>
        <name evidence="3" type="ORF">LDBPK_041150</name>
        <name evidence="2" type="ORF">LdCL_040017100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858177.1">
        <property type="nucleotide sequence ID" value="XM_003858129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F0"/>
    <dbReference type="GeneID" id="13391025"/>
    <dbReference type="KEGG" id="ldo:LDBPK_041150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1400"/>
    <dbReference type="OMA" id="NRHGRLN"/>
    <dbReference type="OrthoDB" id="261884at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="300" mass="31251" checksum="442B500397687752" modified="2019-04-10" version="1">MSSTPNAPRPVIAKRHHPPQYLAPGQHLKVASRKPAPKHGSAAGGDTFAGGPPRDPWEDFDESSEEPRPSSAGHSASQRHQHTTTGGGHPYSGRVSVSRSTERTSPHSKEGSIGGCAVPPKAAPPTDSRAGVGDEGIDRGAAVSSDEDDRYYTITSEPPKLSAAERAKQVLEAQHRALEAKQLKALTQQGVARRPTTLVRNRHGRLNAIAAQPASRAAEEGGPALLIAAAPVSASVQPEKSRVRYSKAPEARTAPSAPRGGEGGSDGAVESPRDSHDDLVGSCPSTTIQATTGSLEIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H605</accession>
    <name>A0A3S5H605_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070014800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_071010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1180"/>
    <dbReference type="OrthoDB" id="267770at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1473" mass="152138" checksum="E6D4B97B39F544DA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H628</accession>
    <name>A0A3S5H628_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_080005900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H628"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0120"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="451" mass="48956" checksum="878BB4D62A82B9EB" modified="2019-04-10" version="1">MGGGATPATAGSQVVDLRALDPSPCPSRGSRSPLRSCHVHERGSRCEDVPATQILEFLYLGSVKDAQDAAFLARHQIRYIINVSQEEYWSVDKKVQIFTFKVDDSATADIAALFQPTRDLINSIRGRYYRYARGESSTRPAVLVHCQKGRSRSATIVLAYLIYTNGWSVAEAMKYVGARRPCAEPNIGFMEELRKLQESLSFEERTRRYSELCWFMRNLNAETSQSHVRELFEKRIGMVRHVVTYVVAGGGAGNVADGGTAGNCGDGSRVTVQRDTRLSASWPAAPSTGYSDAADSLVAFDLGAALGKQNDGLDDQRAAKDSDTHAYKDASAAVSLLRGPSTEKTMLCFVFFTCREDVLHGIKSGQFQQLLLQLPSAAGKQIKYATGPKLKKIMTEHQSMSSSFVQDMAGFSDHATTRTGGESAAADADGAVQTQGVVAPASKEADVTRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Q5</accession>
    <accession>E9BBN8</accession>
    <name>A0A3S5H6Q5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_38930</name>
        <name evidence="6" type="ORF">CGC21_4430</name>
        <name evidence="5" type="ORF">LDBPK_140030</name>
        <name evidence="3" type="ORF">LdCL_140005200</name>
        <name evidence="4" type="ORF">LDHU3_14.0050</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859375.1">
        <property type="nucleotide sequence ID" value="XM_003859327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Q5"/>
    <dbReference type="GeneID" id="13391078"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0050"/>
    <dbReference type="OMA" id="INDGWHK"/>
    <dbReference type="OrthoDB" id="277699at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP53547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="270" mass="30068" checksum="254832DC464567A3" modified="2019-04-10" version="1">MVAWGPLQRRLFAYIARHPQFQQAVRNVGQRVAAHPTFQKAKQSAYSAFERAGTRAARGSSVSGGKGNGSTEESTLNAWRRRINNGWHKHKAGVMSFIAANFMAILIFVQVSPMLWHSVKRGIHYLTDAPSNVEGERKEKPRKRKAEAAEEQSSFKAEAPNDTMRGAVLRRVLPPQTPWGSYTEHGEPASRPSQSWQTSSTLFDDTVGTKQQPDAQQSFNEMHKDVFRTPDGSAQINFDTSFLVKMGDETTFTSSLERETLTGSVSSHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6U0</accession>
    <accession>E9BC69</accession>
    <name>A0A3S5H6U0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonspecific lipid-transfer protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sterol carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_1795</name>
        <name evidence="3" type="ORF">LDBPK_150280</name>
        <name evidence="2" type="ORF">LdCL_150007700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859553.1">
        <property type="nucleotide sequence ID" value="XM_003859505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6U0"/>
    <dbReference type="GeneID" id="13392996"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0370"/>
    <dbReference type="OMA" id="CFGAPWE"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF2">
        <property type="entry name" value="LIPID-TRANSFER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase C-terminal" evidence="1">
        <location>
            <begin position="264"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="405" mass="43450" checksum="6A7B45C2BC67276F" modified="2019-04-10" version="1">MQRIRLVGVGRTAVGALKRDAIDLAREALELAFAEANIAAKDVGALIATPSLSSGHFMQAHYLATKFQLTAANPAMLLKTIDTGGASPISSIGAALDFFRGMPRLNVAVVVSSDAVHTLPSSEFAKRSNESVPSPHLAEPYIPHGYDFYAQWQMKRYGLKREQLAMVPVLMSAMSVRHPDAMCRKRYSLEEVLGARQIAPVTNLPECARRADGAVAIVLAREEHYKQHLAAGPLDGRRPYVLGVGEASGPLYPPATHEEVTSETFSCHRAMRLAYEATGGLSTSDIDFFGLYDCFPICLIRALEAAGLCREGEGGQMVEEAYRRAAQRGGDVDPSEFPINTHGGLMCFGAPWEVPAMYNVAEAVAQLGGQAGPRQVHPTPRRALVYGNGGVFSASAVAILSTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6U3</accession>
    <name>A0A3S5H6U3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150009700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6U3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0580"/>
    <dbReference type="OrthoDB" id="273059at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="345" mass="34837" checksum="C3E5097146044EA7" modified="2019-04-10" version="1">MNVYTSDGLLVSRGADSGGLSTEQGQQLISIYRLFLQLHHAGTGAMRIKDMIKPETTDAVSEHGSGGAGGDKNADHRGGGAGRGGSGAVNATWSAIMPSMPENTAYTSSIAVVSTGTPYPMFLLSSNAIPETHRLRGFASAVAPQQQHHAAAAGTATTASTKNNNRSANGCEEIALRWSLLTKQPPSCPTAAAAAGSAVGAATGASAGTPASMTATVNATKATVMTAETAADVPVDRTGFPGARNFSMSSTKSAGHLPGASQRDRMAGEWSNAGNVAPAATSPARTAALAPCAYPSGWTAAELQVHTTKQMMVCTATELSLDLDGGAEDGNAPLLFCCSTLPISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7R7</accession>
    <accession>E9BNL7</accession>
    <name>A0A3S5H7R7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_321140</name>
        <name evidence="2" type="ORF">LdCL_320017100</name>
        <name evidence="3" type="ORF">LDHU3_32.1490</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863530.1">
        <property type="nucleotide sequence ID" value="XM_003863482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7R7"/>
    <dbReference type="SMR" id="A0A3S5H7R7"/>
    <dbReference type="GeneID" id="13390343"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1490"/>
    <dbReference type="OMA" id="GPFVFNW"/>
    <dbReference type="OrthoDB" id="275536at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="188" mass="22402" checksum="AFD9416349B58DE7" modified="2019-04-10" version="1">MAGLDVAWIPFTVMYLLYLIPPTLMEVYSYYSRGGLVRYEDLKYDDSFCPQYQWNRDTEVYYKRFLDRPTSEAGKAFFSWLDWSSESYDRTIYILRRNLAKQDGEVSPWWRYVYGPFIFNWPKKTWLRGDDAACRKAPAWGVGGEARARKEYEEAKAKGFNKNYHYQIMRKIRREQALKAAQVKAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7W0</accession>
    <name>A0A3S5H7W0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar attachment zone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_340012650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7W0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340012650"/>
    <dbReference type="OrthoDB" id="272636at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000019">
        <property type="entry name" value="Excreted/secreted protein 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="626"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="833" mass="91739" checksum="266AA49F094D1479" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP44</accession>
    <name>A0A3S7WP44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COG4 transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_050011100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP44"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0680"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="2">
        <location>
            <begin position="189"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="906" mass="96837" checksum="F3D93EA4FCBC7B26" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPD0</accession>
    <name>A0A3S7WPD0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060007000</name>
        <name evidence="3" type="ORF">LDHU3_06.0250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPD0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0250"/>
    <dbReference type="OrthoDB" id="262451at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8021" checksum="C91C951D771BBC37" modified="2019-05-08" version="1">MPSAPASSSPASPPQHVVLEDDGEYFDEDPTVGRGVPKDTAGEMAWKPMQPVAASDGFMAAIKQSLLGAKGPAPPTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPM1</accession>
    <name>A0A3S7WPM1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_060016600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPM1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_061150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1300"/>
    <dbReference type="OrthoDB" id="266401at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="890"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1107" mass="119091" checksum="4A9610A550F49972" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPP0</accession>
    <accession>E9B917</accession>
    <name>A0A3S7WPP0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome C1 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cytochrome c1, heme protein, mitochondrial, putative</fullName>
            <ecNumber evidence="10">1.10.2.2</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Cytochrome_c1_heme_protein_mitochondrial_putative /GeneDB:LmjF.07.0060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_1485</name>
        <name evidence="14" type="ORF">CGC21_10075</name>
        <name evidence="12" type="ORF">LDBPK_070210</name>
        <name evidence="10" type="ORF">LdCL_070005600</name>
        <name evidence="11" type="ORF">LDHU3_07.0100</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="8">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.10.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000065">
        <property type="protein sequence ID" value="TPP40859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858463.1">
        <property type="nucleotide sequence ID" value="XM_003858415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPP0"/>
    <dbReference type="SMR" id="A0A3S7WPP0"/>
    <dbReference type="GeneID" id="13391786"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0100"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000018">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5427524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ31740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP40859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP52424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="258" mass="29892" checksum="25F80D8B4096D1C2" modified="2019-05-08" version="1">MAGKKAHPIKRDWYWNHNDRFEIWHSLDWPSVRRGRQIYTEVFAPCHSLGRMTFTHFQGFMTREEIKQLASQYEMIDSEPDAEGNLNRRPGKPTDTLPTPYPNQRAAQFANNGAEPPDLQHAVFGKEGGSDYIFSLVTGYNWGNGELMEIPPFAPELKPGQFWNPYFKGCVLSMPPPLSDGLVDYEDGTPATISQMAKDVVNFLRWSAESEYDDRRVAFWKVITTVGLVNCLLLHYGQKNTNWRIYGRTTFRYWKKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPS5</accession>
    <accession>E9B926</accession>
    <name>A0A3S7WPS5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic membrane protein family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Eukaryotic_membrane_protein_family_putative/Pfam: PF05346</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_070310</name>
        <name evidence="8" type="ORF">LdCL_070006500</name>
        <name evidence="9" type="ORF">LDHU3_07.0200</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858472.1">
        <property type="nucleotide sequence ID" value="XM_003858424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPS5"/>
    <dbReference type="GeneID" id="13391859"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0200"/>
    <dbReference type="OMA" id="HMHERFT"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="617" mass="67209" checksum="3BED605AF325E8FE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRA2</accession>
    <name>A0A3S7WRA2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_100018300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRA2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1490"/>
    <dbReference type="OrthoDB" id="273872at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="322" mass="33332" checksum="111369D5757117CD" modified="2019-05-08" version="1">MKFHLHLVDGSAPARGGAAPFSSPPTAAEATQATALMLFAHMTLRCGHLSDVLAVSASTTPALARAAALQPQQNQLHSGAAQLGNADTSVSEDTQVLQMAGKLLSGVIDNDAAAGLPYMDMDGGDARITPYAYFNSSFSEAEQSLRRAVCILAEGGTAAPPPYFDLIATTDMATFDYIIEYYQQQRVRHGGAVTKGRGTKPVGVMHIVADDPSRAALVLQRVVELMLKRSGWTFSVDARAAAEEEALAAQTEEDDDGDDEDGGGGDAGTAGGRGSVVSAGTGGGGVQAGARSGSVDSWVNHIDEAVHLFAQLFGVDVLVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRN4</accession>
    <accession>E9BAQ9</accession>
    <name>A0A3S7WRN4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="8">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_0900</name>
        <name evidence="11" type="ORF">LDBPK_110710</name>
        <name evidence="10" type="ORF">LdCL_110012500</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859047.1">
        <property type="nucleotide sequence ID" value="XM_003858999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRN4"/>
    <dbReference type="GeneID" id="13389531"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0910"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="278"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="409" mass="44009" checksum="98BD0F6ADE45EC88" modified="2019-05-08" version="1">MDPTLTELLHANLEWIFVGGKGGVGKTTTSCALATLFATTPISDAASPGGTRPRRVLLISTDPAHNLSDAFNQRFGPHPTPVKGLEESLAAMEVDPKNFTHGALMSSLTGTKRDGSASSLPEEAAADAAQHTTTFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLSYDLLIFDTAPTGHTLRLLALPQTLNSTFDKLMSLEGLAPMIEAASHLIGSNLGDLGGACGDTAGSCEQATAAPSPSSAAPGAGSAAAASPQSRWCITADEVRSTALHWRQTMEEVQARFNDPNRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCSARQKIQAKYLEQIDLLYEDFHVVKMPLLSDEVRGVPALKKFARFLQEPYSPETHGYIDVQEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRU9</accession>
    <name>A0A3S7WRU9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette subfamily A, member 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_110018100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRU9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1510"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001592">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF262">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="658" mass="72681" checksum="6B0CCA80A9F9D68F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRZ2</accession>
    <name>A0A3S7WRZ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_120008100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0420"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000034">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="111"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1898" mass="204193" checksum="93CAEA2AD0240AC8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WS87</accession>
    <name>A0A3S7WS87_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Puromycin-sensitive aminopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_120020400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0400"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="13">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="333"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1372" mass="148937" checksum="7243AE0BCE415463" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU02</accession>
    <name>A0A3S7WU02_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160014300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU02"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1070"/>
    <dbReference type="OrthoDB" id="261212at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32378" checksum="152D0B2B53883B7A" modified="2019-05-08" version="1">MSQEMLAESLPLFRAAGHRSSDVIPAAAQRRNPFIVAIGSSCGVQRAADGTASPFISALVPSVCQRSTTCSVTTAHRHLFSKSAGPRRPSEQRCGGNRRLPWRTHFSQLLSEEQITRWRLRCEEQEERVEIALAKPSCRVLFSHADVTAARSARGQGDERLGCDAYSRPHLPRAELVCATANEAHSLRAGRRRIKTKKHCSSGRSGGLQEHPTSETQNTTSAPAPLYVRDSELLRALQRAEARIKQLEAGAVSQASAPWDKENTMNASSSTMAKPQASAFPGAIQPFSPLSSRLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUH9</accession>
    <name>A0A3S7WUH9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_170016300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1460"/>
    <dbReference type="OrthoDB" id="26518at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="685"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="964"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1288" mass="137171" checksum="EB0B9BF8BE3E615E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUS8</accession>
    <name>A0A3S7WUS8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180008800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0470"/>
    <dbReference type="OrthoDB" id="267750at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1694"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1746" mass="183281" checksum="C31D0D0EA61AF549" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVS2</accession>
    <accession>E9BEF1</accession>
    <name>A0A3S7WVS2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_8535</name>
        <name evidence="5" type="ORF">CGC21_18800</name>
        <name evidence="3" type="ORF">LDBPK_191610</name>
        <name evidence="1" type="ORF">LdCL_190021900</name>
        <name evidence="2" type="ORF">LDHU3_19.1950</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860334.1">
        <property type="nucleotide sequence ID" value="XM_003860286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVS2"/>
    <dbReference type="GeneID" id="13386145"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1950"/>
    <dbReference type="OMA" id="AVGWQKI"/>
    <dbReference type="OrthoDB" id="257482at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5429552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="373" mass="40261" checksum="9CA4E93ED3B130C8" modified="2019-05-08" version="1">MPLIGDCMRQLAEQLRGCDGVVAVDPLACASFHEETAARIALEALSLLLLDRPSERRTDGMCAHRRTWCGIGVLRGRESDVAYNSGEGASVLWNVVPVALTVVPWQVELPRRLQDLVLCQGHFASIDQLDYGSSDVGPVPDTFLTREAVALLCGLPRCRVQAVSGRFPLFGRVVPPSFSAAPRGVTATDATWSLVPSREVSPARSAAAAQRHARRLMPFLVSGLSSLMEPFSLRNDRSVPECWAVVSYPDGLPRAEAAREEVDGVSRDISDTAGAVSSHEANVHESDGSCEAAPFFILPSHLLCRSLRVAVGWQKISPSSRPLVSEVLQRLCCLVDRIALRTDRGVTLTSRTACSTGQETLSATMTIQKASSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVT3</accession>
    <accession>E9BEH2</accession>
    <name>A0A3S7WVT3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transmembrane_protein_putative/GeneDB:LmjF.20.023 0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_31930</name>
        <name evidence="7" type="ORF">CGC21_29670</name>
        <name evidence="5" type="ORF">LDBPK_200250</name>
        <name evidence="3" type="ORF">LdCL_200007300</name>
        <name evidence="4" type="ORF">LDHU3_20.0270</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860365.1">
        <property type="nucleotide sequence ID" value="XM_003860317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVT3"/>
    <dbReference type="GeneID" id="13386327"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0270"/>
    <dbReference type="OMA" id="PYYSPDR"/>
    <dbReference type="OrthoDB" id="271730at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="149" mass="17189" checksum="AE1DDE8C40A5AD6A" modified="2019-05-08" version="1">MRQSPTSLYVDSMHSNTLTDHPLTHRSSRDELAYRKRKLTERGQYEQAAKAEEEATQRDREGKAGAETREYYWAILCAVLGYLAAHALVFNYYYPDDLRPNYSPDRGYFDDVAARREELEAVDEMVGLSVLESVYSKRKAAVKRRLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVU0</accession>
    <accession>E9BEY6</accession>
    <name>A0A3S7WVU0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcium-activated BK potassium channel alpha subunit family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Ion channel/Calcium-activated BK potassium channel alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC21_29730</name>
        <name evidence="17" type="ORF">LDBPK_200100</name>
        <name evidence="16" type="ORF">LdCL_200005900</name>
    </gene>
    <organism evidence="16 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860351.1">
        <property type="nucleotide sequence ID" value="XM_003860303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVU0"/>
    <dbReference type="GeneID" id="13386309"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0110"/>
    <dbReference type="OMA" id="QCICAVH"/>
    <dbReference type="OrthoDB" id="257992at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000223">
        <property type="entry name" value="Ion channel/Calcium-activated BK potassium channel alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="13">
        <location>
            <begin position="480"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Ca2+-activated K+ channel Slowpoke-like C-terminal" evidence="15">
        <location>
            <begin position="1044"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU78290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP49980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1110" mass="127234" checksum="9BF9CEBB051F26A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVY1</accession>
    <name>A0A3S7WVY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine synthase TruD, putative</fullName>
            <ecNumber evidence="5">5.4.99.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200013300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="5"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1070"/>
    <dbReference type="OrthoDB" id="271869at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160150">
        <property type="term" value="F:tRNA pseudouridine(13) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000029">
        <property type="entry name" value="Pseudouridine_synthase_TruD_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000034">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF27">
        <property type="entry name" value="TRUD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="864"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1409"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1366"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1574" mass="171950" checksum="67D3F4F07D04D7FC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWD6</accession>
    <accession>E9BF48</accession>
    <name>A0A3S7WWD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_34005</name>
        <name evidence="3" type="ORF">LDBPK_210630</name>
        <name evidence="2" type="ORF">LdCL_210011300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860580.1">
        <property type="nucleotide sequence ID" value="XM_003860532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWD6"/>
    <dbReference type="GeneID" id="13386395"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0680"/>
    <dbReference type="OMA" id="WAIVPPR"/>
    <dbReference type="OrthoDB" id="246027at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="441" mass="47876" checksum="7E1D973EAFD72FF1" modified="2019-05-08" version="1">MRSSAYQLTKVACHAAAKPRSAAPVTGTSSAAGKQAVEELEVYLRVMKTAQRRWAREIVAHETHVRRLMIMEEHCRERLKQQVLKGTREHLKYLTNTDLMAASQLVSPPSVDVFLAYGILPEQVSGFTVYVMGCLVADPNRLNVPLPILIADLSSTWAIVPPRKKEAYNELAAIFRPHLPPRAADVEGNDARATEATTAVPKRRVGGTLKATRRNTASGDAGVRVRAHAPLPRHGRGFQPKPSAAATGKSPVPQVLRSAGKQLQVQRRTATASARAPVPPLTSLSSPTAAATQPSTLPRSAKREHSASKTAACVNNRAGSSVISRSRSQPVAPPPQPRRQPALRAADKAAVAALAEELQLPDAERDAFCQFAEASLHEMEMALNLPFVSPNSDRSSGSSKAKRSAKTPRGGVQLVVKEWLPIAAEEWARKTRRQKRFYMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWH4</accession>
    <accession>E9BF91</accession>
    <name>A0A3S7WWH4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_34185</name>
        <name evidence="3" type="ORF">LDBPK_211050</name>
        <name evidence="2" type="ORF">LdCL_210015500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860622.1">
        <property type="nucleotide sequence ID" value="XM_003860574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWH4"/>
    <dbReference type="GeneID" id="13386425"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1250"/>
    <dbReference type="OMA" id="NDTSWAG"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001570">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001091">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="88760" checksum="113E28CB4979FDDA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX44</accession>
    <name>A0A3S7WX44_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">A2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220012400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX44"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1110"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019082033" description="A2 protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="60679" checksum="4233D76CE7D76D38" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXC4</accession>
    <name>A0A3S7WXC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_16045</name>
        <name evidence="1" type="ORF">LdCL_220022200</name>
        <name evidence="2" type="ORF">LDHU3_22.2140</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP53997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXC4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2140"/>
    <dbReference type="OrthoDB" id="238138at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="103" mass="13060" checksum="EF7942C573A1BCA8" modified="2019-05-08" version="1">MSSEREPVLEVAETSDFWSNPVDHFRPNLKFLSVYVEHQYVVDKWLHIKEKWLKPWYLPWWTPMYQVMTWYSQRNRNLMLVENNLNYRPYRYRRNDEDRKNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXD5</accession>
    <name>A0A3S7WXD5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220022600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXD5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2180"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25251" checksum="DA8C35D9230FE6CB" modified="2019-05-08" version="1">MGVLCNTASNPEKRTATYIPALRALTDNYFATHHPNENESALFFASLRVALRSMLHCSREEVDEFLIDSCKRSVSTSAALDKFLSNKNTSKVAPDATAAKIMQVWMMYDKDNSGDLSYAEMKRLVEGLSFSKDLTERILKPFEDDNRHTIAFSEFAKVYSNAVSFRELGYVFQDLAGGASRPSLATPSPALYATSKARTGMPSFSTRSSLLWAASAPTASRRITSSDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZF4</accession>
    <name>A0A3S7WZF4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_250027100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZF4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2600"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="310"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="608"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113090" checksum="8643F7B4ECD63445" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0Z1</accession>
    <accession>E9BJE3</accession>
    <name>A0A3S7X0Z1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity phosphatase, catalytic domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Dual specificity protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_30370</name>
        <name evidence="10" type="ORF">LDBPK_272130</name>
        <name evidence="9" type="ORF">LdCL_270028600</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862064.1">
        <property type="nucleotide sequence ID" value="XM_003862016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0Z1"/>
    <dbReference type="GeneID" id="13386799"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3250"/>
    <dbReference type="OMA" id="QQHRPCA"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="185"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="352" mass="38573" checksum="873F8E31367CF182" modified="2019-05-08" version="1">MPPKVSELPQQRKNTVHHLPDDDISLFFRVLRFLSAHSHLATLDAATERLDDADRSPSTTPSAPVARRGVQCTQTGTSASVNNQIPTPPVLREPLEEFRMMATNLPIDQEGLEAARKTVCELLEGLCHKLADPAITKELRQKVLLTDGSELLGNSSSSSGALGISAVECGAIRSLSSFGIDSLNQMQEIVPGLWCGSYHPAIDRELMKRHGITHVCCCIGTPPSFPGDFIYMTLSADDRPDYDMTPHFAHTFEFIENALVTNHGGVLVHCGAGISRAPTVVSAYLMRKLRLCSSAAIHLVQQHRPCASPNTGFRQQLYEYGMKIGVREQEPAARRELASESAWRAANALRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1F3</accession>
    <accession>E9BJJ1</accession>
    <name>A0A3S7X1F3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ubiquitin_family_putative/Pfam:PF00240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_281200</name>
        <name evidence="3" type="ORF">LdCL_280016600</name>
        <name evidence="4" type="ORF">LDHU3_28.1510</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862219.1">
        <property type="nucleotide sequence ID" value="XM_003862171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1F3"/>
    <dbReference type="GeneID" id="13386955"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1510"/>
    <dbReference type="OMA" id="FSCGCRG"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="851" mass="93281" checksum="0980979970BE1A1A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1G5</accession>
    <accession>E9BJL2</accession>
    <name>A0A3S7X1G5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Zinc_finger_C3HC4_type_(RING_finger)_containing_p rotein_putative/Pfam:PF00097</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_281410</name>
        <name evidence="8" type="ORF">LdCL_280018700</name>
        <name evidence="9" type="ORF">LDHU3_28.1770</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862240.1">
        <property type="nucleotide sequence ID" value="XM_003862192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1G5"/>
    <dbReference type="SMR" id="A0A3S7X1G5"/>
    <dbReference type="GeneID" id="13386976"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1770"/>
    <dbReference type="OMA" id="YVQRINM"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5431522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="398" mass="45993" checksum="6C57D6BCC9AFD0CD" modified="2019-05-08" version="1">MNRNAKALRRRPPSTRKHGAQTHTERSADVRQHTEDVDQTTDHESSDADAIVIPDTAQLMQSKRLQILADQLERSLRVLGQKLDRMQMRMENAGRGALLPFQLRRAKQEKEELKREIMATQRTIKRLIFMSTQMKQMIALKNEVLQSTRARLLEEIKTLETQVHENAEQIRRGYVQRISMLQRYWPWRQLRELGDTTVGKTFEEELARGPRYRNIGIQNNIQTDYIVQQLHWLQELGNREGVFRGHLRLLEGMVEDLNDITDLLETTMTCTVCGMLYENPVILWPCGHSFCLPCVECLAIAPSLYRCPTCGSIGSEGFVHNLLLAETVAKWMFKDKGYGDTQAPLNAIRVHLPRFRQDSIQSRISQLKKDLRESAERAASPGKDPAERELIAISYRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1H6</accession>
    <accession>E9BJM1</accession>
    <name>A0A3S7X1H6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_22210</name>
        <name evidence="4" type="ORF">LDBPK_281500</name>
        <name evidence="3" type="ORF">LdCL_280019700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862249.1">
        <property type="nucleotide sequence ID" value="XM_003862201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1H6"/>
    <dbReference type="GeneID" id="13386985"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1910"/>
    <dbReference type="OMA" id="NCDTVSY"/>
    <dbReference type="OrthoDB" id="273596at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="342" mass="37142" checksum="C0A6E975AC3F7DDB" modified="2019-05-08" version="1">MTMQGQGNNVPQRHQQSQLDSDDESYTGSSGSYSEMVSEASKRQQQSAAVAERRLSPKVEQGNRTRGLQQTPSPVKRGDAQGTQQEEGGETAQKKGRAARGKAKARTMMNAALEAPVARVRAVTEAVSGRDSQRVTIYVFFCIAWVHLIFVILSSALSQIDVVGGGCYTFWGYKANCDTVSYTRRTVLLQRCSRVRSILQAGSAFSIISVLASAATLVTSWVLCCRLREADRHVRSPSGYANMDEVALAQEPGCNEGIENGSQADAPVYDAGDLKKVMMIVVAFSLACELTCWALIAAIITERYCDEIYLWSTTATYGVGFGLGLTAWLAELIAYIVFATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X240</accession>
    <accession>E9BKJ5</accession>
    <name>A0A3S7X240_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_25830</name>
        <name evidence="6" type="ORF">CGC21_27790</name>
        <name evidence="4" type="ORF">LDBPK_290490</name>
        <name evidence="2" type="ORF">LdCL_290009700</name>
        <name evidence="3" type="ORF">LDHU3_29.0690</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862466.1">
        <property type="nucleotide sequence ID" value="XM_003862418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X240"/>
    <dbReference type="GeneID" id="13387205"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0690"/>
    <dbReference type="OMA" id="QWKAYHH"/>
    <dbReference type="OrthoDB" id="271786at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="318" mass="35571" checksum="F0DE8872F681A9E9" modified="2019-05-08" version="1">MRNRVGDEARQRNGIAVQRIFDRSADQRARTAAQFHRDHGERATVRTGSDRYDGCESTGPSFRVSSTSAAALVGTVGRDDRGVRPAWCDPRCGRLLSRSSLDVPSRASSQMKPAEHTGALPPSHQQPLLAGAAPEQQPTGAVSLEDVNGASRSCFRLEVQKAQHARGIDTSLADAALTPYEARKAQRRAYHHQQAVLRHERTIPRRRVVDPYVHLTGAQADVCLVVPNTYTADRLVERNGGRWVLDNPHRQQLYKGEPIMTRLMQGEFYREGAARRAAGEPRHYLLAKNRRDVRVVSEINRAERQRRQSPSHHCVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2D4</accession>
    <name>A0A3S7X2D4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_290015100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2D4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1340"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="452" mass="50086" checksum="C7A87ADC1648E914" modified="2019-05-08" version="1">MAALASCGFGTVRELLKRIVLGQALAFLNSLTGVSTTKLVNSNASYPVLQSITAYAFIFAFYLPAFLFIIYKHRAQRFSNFRFLNRWWKYAILAVIDLEANYVVVLAYQYTNMISVQLLNCFTVPCVMVMSFFVLRMKFAVTHVVGGVIAIGGLVFLIALDADGLSRSERGSQEVLGDILCLISSSLYATSNVLTEWFVKPSKPAFIFNCCGGNGSGEAKDEVTQASPSTDIQEPSSIFPEEGEIYAAEDHTKVPVFIPVVENLAMMSSFALLFSTIQFFAVEWKMFKPNRSSWTGQDWLFQMVFGVTMLLVYTAMPIIFIISSAAFANISLLTANIYAIIWNVTIFKIYPTKLFFVSYVIIAVGILLYNLTDIVRIPFCARWNYPCGDPFKENGNETETDAEEQVHEAAEGLPQREAGSPSNESGGGKQGDATAKSTCGVSTQLHEQQREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3P6</accession>
    <accession>E9BM29</accession>
    <name>A0A3S7X3P6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_36130</name>
        <name evidence="4" type="ORF">LDBPK_302860</name>
        <name evidence="2" type="ORF">LdCL_300034200</name>
        <name evidence="3" type="ORF">LDHU3_30.3790</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862997.1">
        <property type="nucleotide sequence ID" value="XM_003862949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3P6"/>
    <dbReference type="GeneID" id="13385706"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3790"/>
    <dbReference type="OMA" id="DAINPMP"/>
    <dbReference type="OrthoDB" id="268860at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="104" mass="11780" checksum="06B5D687BE2417F4" modified="2019-05-08" version="1">MPATVKRPLWSLLLPQTYTSRVHALAFHAPTIVFMIAVCAIVSKQSYYRSSLADEDPKTYDRIDRRAYVALPDGRMALVYPIIDTQTSFTRTVISFLDAVNPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4A5</accession>
    <name>A0A3S7X4A5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310016500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4A5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1670"/>
    <dbReference type="OrthoDB" id="266356at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019220678" evidence="2">
        <location>
            <begin position="17"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="419" mass="44709" checksum="A4BD3F83AF8A1FB4" modified="2019-05-08" version="1">MLLRSLPLYAVRVVSASLIESMPSPGMGCPTTGSHATLTFHLHRLHNSESFGVDCDFQSVGGCDEQCFVRGMSADLVASSAALKSVLGDGKAARTSSVRVTSINGIARLTKAAVRELFDSGRDVVVQCAVSAVAGSPSDPRQFDTGLEREEDGAEATRTPKKRGRKPKAPVTGALGSDDTEIVGTSSKNAVKRPGRRARGLSLKKPKVSKKRLRYSGARSAVRQMTSKETDLPADDSVSADVEAVDPASASAADDIDAAAVETLHKLAPVKPVRTRGRRSTKREALLDAKWRSTAAGETSDDVWFAYAEATPAEGGEDDEARPEDAAVPTRRRRGRPAKMAAADAPTEAETVAAAKRGRRRPASRTFEPEKQKKTSGRRGRPRKMDKAVEILDTTQAAEVSSKEKPAEQSEAADAELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5D6</accession>
    <accession>E9BNK9</accession>
    <name>A0A3S7X5D6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_33865</name>
        <name evidence="16" type="ORF">CGC21_20100</name>
        <name evidence="15" type="ORF">LDBPK_321060</name>
        <name evidence="13" type="ORF">LdCL_320016300</name>
        <name evidence="14" type="ORF">LDHU3_32.1400</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863522.1">
        <property type="nucleotide sequence ID" value="XM_003863474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5D6"/>
    <dbReference type="SMR" id="A0A3S7X5D6"/>
    <dbReference type="GeneID" id="13390335"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1400"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5432863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ36837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP47118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="538" mass="59283" checksum="861284F95B142639" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5N2</accession>
    <accession>E9BNV3</accession>
    <name>A0A3S7X5N2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_20550</name>
        <name evidence="3" type="ORF">LDBPK_322010</name>
        <name evidence="2" type="ORF">LdCL_320025500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863616.1">
        <property type="nucleotide sequence ID" value="XM_003863568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5N2"/>
    <dbReference type="GeneID" id="13390903"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2500"/>
    <dbReference type="OMA" id="HDYQYNL"/>
    <dbReference type="OrthoDB" id="266081at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="605" mass="63423" checksum="BE9652911483CF82" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5X5</accession>
    <accession>E9BP63</accession>
    <name>A0A3S7X5X5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_34865</name>
        <name evidence="14" type="ORF">CGC21_21095</name>
        <name evidence="13" type="ORF">LDBPK_323130</name>
        <name evidence="11" type="ORF">LdCL_320037200</name>
        <name evidence="12" type="ORF">LDHU3_32.3910</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
            <location evidence="2 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863725.1">
        <property type="nucleotide sequence ID" value="XM_003863677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5X5"/>
    <dbReference type="SMR" id="A0A3S7X5X5"/>
    <dbReference type="GeneID" id="13391250"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320037200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3910"/>
    <dbReference type="OMA" id="HSENRIM"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000010">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5433072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP43820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP47318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="125" mass="14034" checksum="1C3D25097D275B18" modified="2019-05-08" version="1">MSDSTESTNRFAGNVRQAEAPNEKTLRIKVSALKRTIKDLEFAKREVERELQRLDTLRQSDPDRVPQQTKVVDEAQMMVPHSVNRIMASVKDLSDYLEKEGSTVSNEELLDLARATMADGQAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6R0</accession>
    <name>A0A3S7X6R0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330021000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6R0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330021000"/>
    <dbReference type="OrthoDB" id="274489at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13298" checksum="83ACB88118CDF018" modified="2019-05-08" version="1">MLHLTEFTESMSSFLLRSKSDLLVTMTRHFTAKWVTTTVEAAMADLDALTGGLLNFSHAEGGTRAAPSLRSPRSPARLQLFSPHPGSSHLGCSTEKRISGPVSRPMPPSRAAATAVGATVGLPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7U1</accession>
    <name>A0A3S7X7U1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340023500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7U1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2560"/>
    <dbReference type="OrthoDB" id="267567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23843" checksum="3904F077BF9C6FB3" modified="2019-05-08" version="1">MSALPLSPLYVHIGQKKYNVSLVVYVVVQFVAFLLVLVGTPLDMFRSKMETGYGTVRCITLWGVKENCASLDYDLTMYLFFSSCETHILRFRKSQRCAIISILVYMAGLIAGVVNLHGYTTLRWVCLALNIVGSVTLCVVWAAMAVTYNKNEDSRCTRLKALNYEFGVGFFLLVVAWILDIINIILLPLSFTYTYDKEHQMTELPTSEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X819</accession>
    <name>A0A3S7X819_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340031500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3950"/>
    <dbReference type="OrthoDB" id="268062at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026203">
        <property type="entry name" value="IHABP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956:SF6">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="901"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1829"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1945"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2061"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2177"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2293"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2409"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2525"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2641"/>
            <end position="2682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2757"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2873"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2989"/>
            <end position="3023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3105"/>
            <end position="3146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3221"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3337"/>
            <end position="3371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3453"/>
            <end position="3487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3689"/>
            <end position="3744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3760" mass="389674" checksum="367852FE316C828B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8E6</accession>
    <accession>E9BRA5</accession>
    <name>A0A3S7X8E6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_26850</name>
        <name evidence="2" type="ORF">LDBPK_343070</name>
        <name evidence="1" type="ORF">LdCL_340039600</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864466.1">
        <property type="nucleotide sequence ID" value="XM_003864418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8E6"/>
    <dbReference type="GeneID" id="13387345"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340039600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5230"/>
    <dbReference type="OMA" id="YARFRWA"/>
    <dbReference type="OrthoDB" id="262751at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="478" mass="51429" checksum="823AF69A33B51F92" modified="2019-05-08" version="1">MTAHNALLRGSRDDDVDISVRRGAHADTLTVDGAAARLLSAIASYTKFAAATDVEAESSGDAAQEAAALSLMAHMQRLSLLCNAARTPETSCTSAGQGNIHKCVDDWAKWLLGLESQPIVLASKVALCLPPLQACWRGGSAVDGAGSAHIDRIEEAIGSFFARAARRCVTEWTTHGTPLRTLLPPLALLATYARFRWAWSRFTELGHVGGDEHLGGAEGGIAVIGSADAMHRQESRYIDFLSIAGEVESCHADKLTREVLLHSLKTIDWRAGNAVPAVKEVAPLVWCVFLRCRSYALHSHSQNHSSFSDFFAHEASARLVAQVLRCTVDGVRLCIERQAADMHVARATQLCTCDIPCLVLLTRLWFSWIALATDAATVLLPRLERSLRKLVSSAVKLRGGAETKPPSSTVAAALAENSGEVSRTEQETLFVEVAWKVAPLSMSEIASATAAVPWADAFARAREVQAVLEKRTLVAPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8F5</accession>
    <accession>E9BRG8</accession>
    <name>A0A3S7X8F5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_20650</name>
        <name evidence="5" type="ORF">CGC21_27150</name>
        <name evidence="4" type="ORF">LDBPK_343700</name>
        <name evidence="2" type="ORF">LdCL_340046400</name>
        <name evidence="3" type="ORF">LDHU3_34.5950</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864529.1">
        <property type="nucleotide sequence ID" value="XM_003864481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8F5"/>
    <dbReference type="GeneID" id="13387408"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340046400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5950"/>
    <dbReference type="OMA" id="CQERAHE"/>
    <dbReference type="OrthoDB" id="270593at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="304" mass="34416" checksum="BAB0A4BDBA56963C" modified="2019-05-08" version="1">MGHHADPNKYVAYRDATVLQRRIATFVLVFSVMIIALVMTFSSVQHREAPCQDRAHEVEFDFMIRPDSTHEAIVTALQTILEKRRCWLDFAPQNDDAPTMVQLNVLDTTTGLIAGRGFRVVRRSDGSNYHYELRAVFDKLCGTYPPISMEVMANVDYERVTYNIKAASLMNSTVKYLQHSSLLTKEKNRVTTVTQLQSVFPGFHQLGPSTARLSTIQSAKYTVEGVSQVYFNGSPLDIRVRVQHWLSDKGTPDFWRVVLSTQNIMAERDLVSLQSSIREGLTKLNLLCNATSSSCANELDLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X978</accession>
    <accession>E9BS80</accession>
    <name>A0A3S7X978_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calcium_motive_p-type_ATPase_putative/GeneDB:LmjF.35.2080</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12 14">calcium motive P-type ATPase, Putative</fullName>
            <ecNumber evidence="12">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_352080</name>
        <name evidence="12" type="ORF">LdCL_350026000</name>
        <name evidence="13" type="ORF">LDHU3_35.2690</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="12"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864789.1">
        <property type="nucleotide sequence ID" value="XM_003864741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X978"/>
    <dbReference type="GeneID" id="13387668"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2690"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000123">
        <property type="entry name" value="Calcium motive P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1109" mass="121918" checksum="683573FC861099FD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9K3</accession>
    <accession>E9BSI6</accession>
    <name>A0A3S7X9K3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_7060</name>
        <name evidence="3" type="ORF">LDBPK_353160</name>
        <name evidence="2" type="ORF">LdCL_350036500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864895.1">
        <property type="nucleotide sequence ID" value="XM_003864847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9K3"/>
    <dbReference type="GeneID" id="13387773"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4130"/>
    <dbReference type="OMA" id="MTIEYVV"/>
    <dbReference type="OrthoDB" id="273232at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="598" mass="64790" checksum="254D6141B928F635" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9Z7</accession>
    <accession>E9BSZ8</accession>
    <name>A0A3S7X9Z7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_354790</name>
        <name evidence="7" type="ORF">LdCL_350053000</name>
        <name evidence="8" type="ORF">LDHU3_35.6300</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865056.1">
        <property type="nucleotide sequence ID" value="XM_003865008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9Z7"/>
    <dbReference type="SMR" id="A0A3S7X9Z7"/>
    <dbReference type="GeneID" id="13387934"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350053000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6300"/>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000066">
        <property type="entry name" value="Glycine cleavage system H protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11635" checksum="B5B1D83C91A3A56F" modified="2019-05-08" version="1">MQCEDEITIGISSYAQENLGDVVYVSLPQVGDTVKAKDVIGEVESVKATSNVYSPVDGTITAVNENLKDQPGLVNQSPEEKGWLIKVKCSEIPKGLMDEAAYKKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA28</accession>
    <accession>E9BT36</accession>
    <name>A0A3S7XA28_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger C-x8-C-x5-C-x3-H type (And similar) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_8025</name>
        <name evidence="7" type="ORF">LDBPK_355170</name>
        <name evidence="6" type="ORF">LdCL_350057500</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865094.1">
        <property type="nucleotide sequence ID" value="XM_003865046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA28"/>
    <dbReference type="GeneID" id="13387972"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350057500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6890"/>
    <dbReference type="OMA" id="WSVCTFF"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000017">
        <property type="entry name" value="Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="257" mass="28254" checksum="8D6FCF9B46EF0C7C" modified="2019-05-08" version="1">MSQQQWTPDQRRQQIAEMLRNKGVICRDFLFTGRCSRSPTCPYMHVANGETRPVPWSVCTFFTQGKCLRDGCSFFHGTQAQLEELHASGAPVYRPQDYMKVAVPPAEYLNPDGSIATHLSIAALPMTPALHVVHGPTVPHENAVNSLHPVLVMQPNSQAIAPTIFASQGHTAQPTPSHFAFYANAPIASQMPTHSAATVLQPALHAVQPTAFYQATNAPLTQPQQHFAPVPQLNTPQQHQPTQQALGSHVYFHIQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA33</accession>
    <name>A0A3S7XA33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350057900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA33"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350057900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6950"/>
    <dbReference type="OrthoDB" id="258686at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019537022" evidence="2">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="269" mass="29004" checksum="07D9EEEAD47510BC" modified="2019-05-08" version="1">MHLFALLLLLSLVIGLMLAVPGRGARKCFVTDAAPAVPFGLELCYMHSHNACCLPGNDKDIQTAYSALVPKGQGCVAGSQRIYTSLYALRQYLCLPCDPKEPLYRFESVKGDMVDGGLVPPSTNSVAGEQTWRICRSFLYGKEGTRKGLWGHDGSRYAECGVIVSSCMSTPVFNITAASFQSPSPSCVASNELIIPSITFRGFPNPALEMLSMVTQSIPDFQIVIVNDSDPNYDYDKTPCFGRDATAAVASATLSGWVSAVALVLLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA38</accession>
    <accession>E9BT46</accession>
    <name>A0A3S7XA38_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_355270</name>
        <name evidence="2" type="ORF">LdCL_350058500</name>
        <name evidence="3" type="ORF">LDHU3_35.7030</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865104.1">
        <property type="nucleotide sequence ID" value="XM_003865056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA38"/>
    <dbReference type="GeneID" id="13387982"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350058500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7030"/>
    <dbReference type="OMA" id="SHGTQPW"/>
    <dbReference type="OrthoDB" id="277060at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="316" mass="35287" checksum="615619F2467E855D" modified="2019-05-08" version="1">MKNILPPLTCDCCQTFSTLSAVLLSSLGFAAMLSECCSLSTVNYLLYISAWMHQLTLPCWPQKRVRPTIGDLNACLYLRDFFPSKANADEFEVVFYNQAHKAVDLLHAMRTPRKRTRSSDGAHPVYGYVIVSGDYTVSVFSVEHDIAKGSRSRYREAWSFYICDSHGTQPWSEDKASVSGLTFGHRSHDVDDTKVEEEASNGSGTASSAADLSVEDGIYYFSTILFTLLEEHRKGAQRTSQVPYMTWTPLRRRRSLAYTAQELKRIIDNHWIPKVLSNPTVQAEAKKFSFKPLECFWGIGPVTAAKTSPVSGASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAT8</accession>
    <accession>E9BTQ2</accession>
    <name>A0A3S7XAT8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable eukaryotic initiation factor 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CGC20_28980</name>
        <name evidence="21" type="ORF">CGC21_13265</name>
        <name evidence="19" type="ORF">LDBPK_361930</name>
        <name evidence="18" type="ORF">LdCL_360024800</name>
    </gene>
    <organism evidence="18 23">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 22" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18 23" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 23">LdCL</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="25" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865308.1">
        <property type="nucleotide sequence ID" value="XM_003865260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAT8"/>
    <dbReference type="SMR" id="A0A3S7XAT8"/>
    <dbReference type="GeneID" id="13388194"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2520"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000892">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="84"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="281"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ38631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP48303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="527" mass="59373" checksum="B7C64CE420C822B7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC16</accession>
    <name>A0A3S7XC16_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360070200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC16"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360070200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8330"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000021">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019042589" description="Ubiquitin thioesterase OTU" evidence="4">
        <location>
            <begin position="30"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="5">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="385" mass="43110" checksum="B05FD71AC399DDE5" modified="2019-05-08" version="1">MGCTAHTQTHTRSLCLTTFALLHWPVSHACATQCLYVFSLLRLQQSTHEVLRSRCAFSTFLFLFCIHRKASVPQPLTALSCGRCAPTVEPRFSVFSHRPANTQTHTQTQTERHLPCIMSISVRIRTPKSSTPEQVELNSSGTWGEAAALLSRKSEVALERLRVLAGFPPKAVDLAADSPLSALKLRANDMLIVQEGEAKVQLGNRGERYLPPAPERAHLTRRRCPADNSCLFHACAYVLRDKSRTEGPQLRQECVQAVLDHPEMFNVNTLGMDPLAYASWLSEKDTWGGAIELEILSFLYKTEIFALDLQSVTLQRFGTGMGYTVRAFLVYTGNHYDCIAMNPVYNPTSEREDQTLFSSRDENVLARAKRFVAEEGQKMKEGKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJM0</accession>
    <name>A0A451EJM0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_5860</name>
        <name evidence="1" type="ORF">LdCL_030006400</name>
        <name evidence="2" type="ORF">LDHU3_03.0140</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000066">
        <property type="protein sequence ID" value="TPP53883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJM0"/>
    <dbReference type="SMR" id="A0A451EJM0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0140"/>
    <dbReference type="OrthoDB" id="238481at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="311" mass="35449" checksum="43FC6F12C93F2EC1" modified="2019-05-08" version="1">MAAPASHYTFANLKKLGLCAPQVALSRQPRLRPHVGHLNGLVYPLPYYAMWRGNHDKYTYNQATPARWGEGNTNTMYHQHYAHAKCPTDYGRGGREFQFLSVQRGKLKRKPLPTVQYVGPNSKPQWVFKSWHNPLSAPSMWEREVQYPEHTPEHTGAKRPLAVVAPKTSHKHLFLMHMEKVTVTVSPLLFGYGHTLQKAALDFYRRGLSARSPFPNDKMFLYYSIDHITPKIEVTWLDGSVYVPPLIEGVKAQDLIQMVMEQAWLAADRMSAEGRVLNPIAIDDYKWEQLIAFKQKRAKGAEAAKGSAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJS2</accession>
    <name>A0A451EJS2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_030012300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJS2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0800"/>
    <dbReference type="OrthoDB" id="273730at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="404" mass="42840" checksum="24F7AAD77E251579" modified="2019-05-08" version="1">MAAPASSATLPSVLQLTANASAGGKRPTRGVTMSALKQASKAASAAPSPPSPSPSFHVFADLPDHLLCSPDNSVWVYGQYTLSFLTSEAAAQAKLERKVRCMMREAQRQYDISCAFFHSLTSEEQMAEVLRVGSGGGVLSLPPAMTAATGTSAKSDRKRLTGVHRALRDTWPTWRGPDMSDAANGLAAREVGGAGEGKSSANRYSAGLRVNLVLDIVASRKTLRTVPLRSRPYRLAEYLYQLVMRPSATQRATAAPAQGDMALHVRSLIIGISDADTTLVGCHVVCPYRHLTSPTPMMMRLRRAIEGAADQERARALAAAEAANTTVSGLDTQWQASSAAAAAEAAASDAAPSPLRSLVASQLARYRCVDALFPAPYVRVPPQSLEQIDQSRLILCTPGKLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7Q6</accession>
    <accession>A0A3S5H540</accession>
    <name>E9B7Q6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_030380</name>
        <name evidence="7" type="ORF">LdCL_030008800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858003.1">
        <property type="nucleotide sequence ID" value="XM_003857955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7Q6"/>
    <dbReference type="GeneID" id="13390378"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0390"/>
    <dbReference type="OMA" id="ELQEWEY"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="PhylomeDB" id="E9B7Q6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015360">
        <property type="term" value="F:acetate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="303" mass="32779" checksum="D0E80AE7F88231DC" modified="2011-04-05" version="1">MSTISGPNGKPAHEPVTSAAQTNADLYVFHEKYSCGNVSQTALGRQDALALNKNGKSLRESSRKLKRKRLCELQEWEYQAATAPRRCANPGPVGLLGFGLSTILLNLHNTGSFPLSTVIVAMGICLGGGAQFIAGLLEWVRGNTFAYVAFTSYGAFWLSLVCVWMLPNTAAGTSKLVDPASEYFVGVYLFLWGIFSFVMLLCTIRMNLAIFLVFLTVTLLFLMLGCSSMASSAVGLRAAGYEGIICGSLALYLAFAEILNEMWDRTILPVIPMTQVLGWLGASPEKASDSAELENHEQLPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBL8</accession>
    <accession>A0A3Q8I8N4</accession>
    <name>E9BBL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_131440</name>
        <name evidence="1" type="ORF">LdCL_130021700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859355.1">
        <property type="nucleotide sequence ID" value="XM_003859307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBL8"/>
    <dbReference type="GeneID" id="13390782"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1970"/>
    <dbReference type="OMA" id="ERIDMCG"/>
    <dbReference type="OrthoDB" id="261100at2759"/>
    <dbReference type="PhylomeDB" id="E9BBL8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="457" mass="49283" checksum="4ED8CE6A294D9ED9" modified="2011-04-05" version="1">MDIWTAELRRAHSWLLADDTYRNSAMKPQRLLGHLEGDAVVEMIKFAPGNSRLTLAAVSPKVRLLAELLESRLPTTLRLLLDDATVMHELVSDAAGASLLQQLDAVAWWIEKCGIPVSVRGDQTAVTLLTSSRVRPIVRGVSLSLLVRACPIPADLLLRLERIDMCGEAFASLPADPSQMVQLRELHVSRCTSAALLRLYQLPSLTTLSIESKIGVEPVGNENVAQNPQQNLGVDEIDMHLMTSARSLQHLRLSSSGLSMVSGFDCCESLATVTVVNCERLLSLSSLAHAVHLRSISISWSGVRDLGALAACPCLERITFDTCRAVESLTALAGAPRLREVDVFCSGVRDVNGLASCPYLETLCVTACRFVTDLSPLAGAPRLRIIDASFSAVSNLQGLGTCPSLEVVRLDACIAVHNLNPLADAPRLKYVFVRGLDHAALLYPSSLTPKIFPAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCU4</accession>
    <accession>A0A3S7WU61</accession>
    <name>E9BCU4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Flagellar calcium-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_160910</name>
        <name evidence="12" type="ORF">LDBPK_160920</name>
        <name evidence="10" type="ORF">LdCL_160014400</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859777.1">
        <property type="nucleotide sequence ID" value="XM_003859729.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024329228.1">
        <property type="nucleotide sequence ID" value="XM_024473456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13393188"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160910"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1080"/>
    <dbReference type="OMA" id="MECALSF"/>
    <dbReference type="OrthoDB" id="272063at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054322">
        <property type="entry name" value="FCABP_EF-hand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22592">
        <property type="entry name" value="FCaBP_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Flagellar calcium-binding protein EF-hand" evidence="9">
        <location>
            <begin position="1379"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1504"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1654" mass="184210" checksum="7115AB80FDC072F6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BED4</accession>
    <accession>A0A3Q8IEM2</accession>
    <name>E9BED4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_191450</name>
        <name evidence="10" type="ORF">LdCL_190020200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860317.1">
        <property type="nucleotide sequence ID" value="XM_003860269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BED4"/>
    <dbReference type="GeneID" id="13386129"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1760"/>
    <dbReference type="OMA" id="WAAVCTD"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="PhylomeDB" id="E9BED4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF98">
        <property type="entry name" value="RNA EDITING 3' TERMINAL URIDYLYL TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="478"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="933" mass="103983" checksum="24B83226DA6889F8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEW3</accession>
    <accession>A0A3Q8IDS1</accession>
    <name>E9BEW3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_201650</name>
        <name evidence="6" type="ORF">LdCL_200021300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860505.1">
        <property type="nucleotide sequence ID" value="XM_003860457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEW3"/>
    <dbReference type="GeneID" id="13386288"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2020"/>
    <dbReference type="OMA" id="PANVEEC"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="PhylomeDB" id="E9BEW3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1279" mass="138367" checksum="530D5F3F225EFA8C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEZ6</accession>
    <accession>A0A3Q8IA76</accession>
    <name>E9BEZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_210110</name>
        <name evidence="2" type="ORF">LdCL_210006000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860528.1">
        <property type="nucleotide sequence ID" value="XM_003860480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEZ6"/>
    <dbReference type="GeneID" id="13386372"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0120"/>
    <dbReference type="OMA" id="QIECAAQ"/>
    <dbReference type="OrthoDB" id="271900at2759"/>
    <dbReference type="PhylomeDB" id="E9BEZ6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="285" mass="31279" checksum="1EF2DBA90F6672D2" modified="2011-04-05" version="1">MESAVKCVDATSRCLRLFNPTRTITQSKGMTTLAKLYGTGAAPHERVITFLMHIRDAFDGVLPVEIALSGGHCLQRLDPSAADEYLLAFVTDWLALAAAADEQADPFRRRFRDRLSTDNAQKTFHLHFRAAVLLQIECAAQSGRKHVFAAYNTQVMDAILTPFTREELQKYEATCWQEAARHREVESVVAVPFVSAAPASTVSSALAAYKQQGTQRGTSTEARRGGAVAPSSSGMANWRHDAIRILAFLLLAVLLRFAWGPLARALKSVLQVTRAAPARQRTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BF66</accession>
    <accession>A0A3Q8IB36</accession>
    <name>E9BF66_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_210810</name>
        <name evidence="9" type="ORF">LdCL_210013000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860598.1">
        <property type="nucleotide sequence ID" value="XM_003860550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BF66"/>
    <dbReference type="GeneID" id="13386411"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0910"/>
    <dbReference type="OMA" id="VWTAEVV"/>
    <dbReference type="OrthoDB" id="263676at2759"/>
    <dbReference type="PhylomeDB" id="E9BF66"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11957" checksum="BB96E23B0AF51070" modified="2011-04-05" version="1">MKADCSLSSHQLKKLDKKMGDSTIIDRDALTESQKWSYITDNTLKMMSLGFLCGGAVSMVVFRSVASRAAVTAFGTGCGIGKSYVDTKYVLGHDVAAETVWSAQVAPPKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHR9</accession>
    <accession>A0A3Q8INI9</accession>
    <name>E9BHR9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_251650</name>
        <name evidence="3" type="ORF">LdCL_250022200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861495.1">
        <property type="nucleotide sequence ID" value="XM_003861447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHR9"/>
    <dbReference type="GeneID" id="13388741"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2090"/>
    <dbReference type="OMA" id="QDRMFYL"/>
    <dbReference type="OrthoDB" id="244235at2759"/>
    <dbReference type="PhylomeDB" id="E9BHR9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="677"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1169" mass="121805" checksum="FC77E8E3D01E64C4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJW5</accession>
    <accession>A0A3Q8II93</accession>
    <name>E9BJW5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_282450</name>
        <name evidence="17" type="ORF">LdCL_280029500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862343.1">
        <property type="nucleotide sequence ID" value="XM_003862295.1"/>
    </dbReference>
    <dbReference type="SMR" id="E9BJW5"/>
    <dbReference type="GeneID" id="13387079"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3310"/>
    <dbReference type="OMA" id="DVKPHMI"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="PhylomeDB" id="E9BJW5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000014">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000024">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000109">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000136">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="425"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="16">
        <location>
            <begin position="681"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1229"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1423"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1060"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1239"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1255"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1294"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1304"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1369"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1423"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1446"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1465"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1475"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU80399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1498" mass="168476" checksum="B7AA92E87B082775" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNJ8</accession>
    <accession>A0A3Q8ID08</accession>
    <name>E9BNJ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_320950</name>
        <name evidence="2" type="ORF">LdCL_320015100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863511.1">
        <property type="nucleotide sequence ID" value="XM_003863463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNJ8"/>
    <dbReference type="GeneID" id="13390324"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1240"/>
    <dbReference type="OMA" id="CALEEMQ"/>
    <dbReference type="OrthoDB" id="260006at2759"/>
    <dbReference type="PhylomeDB" id="E9BNJ8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14841" checksum="462AD8805596834B" modified="2011-04-05" version="1">MSSSTSVTDGMTQMVVSQASLDGVFLEALLGQELNLALWRSCGAPQEALQCALEEMQRLDQAACEEDAALRYLNTTRFAEQRTYKRRRAELQSQLQKTREKVFALEKLVRVETAGSSPREVGAGERLRACLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR56</accession>
    <accession>A0A3Q8IFP3</accession>
    <name>E9BR56_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase-like protein</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_342580</name>
        <name evidence="6" type="ORF">LdCL_340033400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864417.1">
        <property type="nucleotide sequence ID" value="XM_003864369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR56"/>
    <dbReference type="GeneID" id="13392826"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340033400"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="PhylomeDB" id="E9BR56"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000700">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000701">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="5">
        <location>
            <begin position="378"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="427" mass="46718" checksum="C34F039ABCDA37DB" modified="2011-04-05" version="1">MPAPRPELENPPEVFYNASEARRYTVSTRVRKIQRDMTLRALELLNLPKDDAAAATGVNCSALLLDIGSGSGLSGDVLTEQGHVWMGVDISRDMLRIAKEDELHYYDVGAAQKSAEAEEAYQTSSSNARFDTSHVKWGLITSEDDQEEVSESEGGKGVDGDDDDVASGDLASSAAAGNGAGGAASGPRMVEVLQNDIGVGLPFRPGTFDGCISISVLQWLCHSTKKGEVPQRRLMALFQSLYNALRRGAKAIFQFYPSNPEQVHIITRAAMKCGFDGGVVVDFPHSARAKKYYLVLQAGQVQGGFVPPAALTGEVEGDGDDDGSDGDSEYDGEEYYGSGEDGDDDDDDDGLHNPNSRKRVRVGGRDAHHGKRARASSEHGQKRRRKDNRPVTGTREWVLLKKEERRRRGYQTTADSKYTMRRRKPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRG6</accession>
    <accession>A0A3S7X8I0</accession>
    <name>E9BRG6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_343680</name>
        <name evidence="3" type="ORF">LdCL_340046200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864527.1">
        <property type="nucleotide sequence ID" value="XM_003864479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRG6"/>
    <dbReference type="GeneID" id="13387406"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340046200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5930"/>
    <dbReference type="OMA" id="FKECCED"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="E9BRG6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000190">
        <property type="entry name" value="DnaJ domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="706"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="780" mass="85514" checksum="1BEEB2DDFF774C0C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8Z5</accession>
    <accession>E9BC44</accession>
    <name>A0A3Q8I8Z5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP diphosphohydrolase</fullName>
            <ecNumber evidence="6">3.6.1.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">GDA1/CD39 (Nucleoside phosphatase) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_1925</name>
        <name evidence="7" type="ORF">LDBPK_150030</name>
        <name evidence="6" type="ORF">LdCL_150005200</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859528.1">
        <property type="nucleotide sequence ID" value="XM_003859480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8Z5"/>
    <dbReference type="SMR" id="A0A3Q8I8Z5"/>
    <dbReference type="GeneID" id="13392986"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0030"/>
    <dbReference type="OMA" id="ENPFHRH"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="425" mass="47204" checksum="510868675437132D" modified="2019-04-10" version="1">MRPYSSVRRMTQQSKRLRIAGTLVLSALVIFGFLVYYQSPLLSPCDSAYANVYDVVIDAGSTGSRVHVFQYERGRTGLVLLRERFKRVEPGLSSFATDPDGAKESLAGLLRFADKVVPQSYQKCTFVTLKATAGLRLLPESVQQVLLDAAQHTLNASPFQSRGASIISGAQEGVYGWLTVNYLLNRLDTDVATVATIDMGGASTQVVFETTPTSGEWLPFNYAHQLRTPKRTITMYQHSYLGLGMNEAKKKLMMSFAEANGTSSFPCFPRGYAKRLNDVELRNSDATDFDACAGLFHEHVITKTTCKFDACGARGVPQPLFPSRRHLIYAFSYFYDRLYHFSKEGSPVYVSSYKEVGQEVCHRESARRTTAPEETACMELAYMYSFLTYGLGLSDATALTVPNRIEGMAVSWSLGSSLSFLLKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9I3</accession>
    <accession>E9BBA5</accession>
    <name>A0A3Q8I9I3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-binding enzyme family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty acid-CoA ligase protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid-CoA ligase, putative</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_33115</name>
        <name evidence="5" type="ORF">LDBPK_130300</name>
        <name evidence="4" type="ORF">LdCL_130008500</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859242.1">
        <property type="nucleotide sequence ID" value="XM_003859194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9I3"/>
    <dbReference type="GeneID" id="13391066"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0430"/>
    <dbReference type="OMA" id="PNAMQGY"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="669" mass="74107" checksum="AA323BFC11162914" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9N9</accession>
    <accession>E9BBF6</accession>
    <name>A0A3Q8I9N9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase 25 (LPS biosynthesis protein) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase_family-like_protein/GeneDB:Lm jF.13.0930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_17185</name>
        <name evidence="8" type="ORF">CGC21_33345</name>
        <name evidence="7" type="ORF">LDBPK_130820</name>
        <name evidence="5" type="ORF">LdCL_130013600</name>
        <name evidence="6" type="ORF">LDHU3_13.1030</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859293.1">
        <property type="nucleotide sequence ID" value="XM_003859245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9N9"/>
    <dbReference type="GeneID" id="13390483"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1030"/>
    <dbReference type="OMA" id="EHRECAL"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="4">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5428457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP50090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="275" mass="31184" checksum="7DA9A1284378BB0B" modified="2019-04-10" version="1">MLRACRRRHTIFDACYVLNLDRRPDRWAHVQQQVKRAKLHKFLKPGVEVTRVSGIDGHELDVASLHRDGVLTDRGYQRYQLPTEQKLYGMDLTKGAIGCALSHRAVWQRVVAEHRECVLILEDDLEFHHQFSRQFAERWSRVPADWGIVHMGGLDLLASGKAPRPYIADGIRLAYEGHRELTAYVAHAASAQRCLDLSLPMTWQVDTHISSCLADDAAAQDKYIADPKMYVFQPSLVIQLMSFTTDVQKKPTDNPALADAARRLREFVGGGTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9U0</accession>
    <name>A0A3Q8I9U0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_140010800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9U0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0740"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="205"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="504" mass="55347" checksum="C16A67642D2F8270" modified="2019-04-10" version="1">MELRERVGKLSRAQAPTAVPPTSNPMTQRLVSLEHDEMSHLWFRGVMAFLAFLCFMLSILQVSGYAGNVVVHVLILALSLAGEVCIVVVYRIKARFAGVTNPASHAVNSLHSPHLSLMLCEMLVWIIMAPPGVKGTSSWARVLDSFIVLRSYVYVMYVTRLSTQSVFKRAVASLCGYRFNSLYMFRHTFIYRHAIATACGFIVAWLGMALLYSKGEEVSYADAVYFCSSTMGFVGYSDVVPSTWVGRFTAFLAWCLGLLVIAWCVSLMHALTRVTPAERNLHTLFRTNKLCAQVPGEAARTIQRAWKLYLAKLEKRNPLSIQFNALLLSSQACSFRSLRREFVESEMAFIRSTYTFDDALTALSRQSSLRTTPAGSPRSPMSTALSASSGTPKSTTGRRSFSLFKEVKLKSPQISPLPPGANVETGCSDGGAPPPASSSTSLPVLELRGLINQRQLTHSGTGASAMASDITRRLAHLDETLSILIRKAERMAPRMLASSTEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9U8</accession>
    <name>A0A3Q8I9U8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140007200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9U8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0300"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="106" mass="10691" checksum="08AFE7A7E0A9977A" modified="2019-04-10" version="1">MARVNSGIGCSATSAAEAAGYGAPLSVSSASRTDEKPEPPGTAPSSPSSHDGNACATFIEAVCPSADSVANSQLVPYIEFACCSNYSSTATLCGGMMRLMRSGKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9W7</accession>
    <name>A0A3Q8I9W7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Stearic acid desaturase, putative</fullName>
            <ecNumber evidence="15">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_140010600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="15"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9W7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0720"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000033">
        <property type="entry name" value="Stearic acid desaturase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="341"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="467" mass="52740" checksum="A7A339B40C517F88" modified="2019-04-10" version="1">MLQAVQNLFTCSVLSTDETKPKEEREVPQWSKGNFQYNWIGIYIIGVPLLFVLLGLCLRVPLSFSLLQWLAFFGVVTGMVGVTTGYHRLFSHGAFTGGQAMQWVCAFIGAGAFQGSIKWWARNHRVHHKYTDTSKDPYDARRGFIFTHFGWFVMRMDYDLLGDADVSDLKDSLVVEFQRKYFAAIATMTGILIPLMVAGATTGEWAGAFFWVVWLKIFLVHQFSFFINSLAHTDLFGATRPYADDKTPHDSVVFAIINLGEGYHNYHHQFPNDYRNGHLWYHIDMTKWYIFMCSFLGFCDNLQRAPRTVVDRAAAVQAVCTHGRKLQEAVEKVKQLEVPADKEYAWDDVRAEVEQGRKLLVMDGYVLDLERPIPVDPAWAQTDKKISWLNTHPGGRALLLAYVGKDATAAFNGGVYGHTTGARSYLPELRVGHMKERLASSASGKEGSAAVCKGQCITLPRRRDVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAD3</accession>
    <name>A0A3Q8IAD3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_160015900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAD3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1320"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="3">
        <location>
            <begin position="531"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="978" mass="107817" checksum="7065E63DB21B5847" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAN8</accession>
    <name>A0A3Q8IAN8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase T, putative, metallo-peptidase, ClanMH, family M20B</fullName>
            <ecNumber evidence="10">3.4.11.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_170008000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.14" evidence="10"/>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAN8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0480"/>
    <dbReference type="OrthoDB" id="25978at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03892">
        <property type="entry name" value="M20_peptT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003976">
        <property type="entry name" value="PRK05469.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009920">
        <property type="entry name" value="PRK13381.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994">
        <property type="entry name" value="PEPTIDASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PEPTIDASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="217"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="423" mass="46940" checksum="EB6C0BEF95F66B99" modified="2019-04-10" version="1">MSLAPIEHRLEQRFRRYSAITTQSDPRNLGKCIPSTPGQQVLAELLAKELQAMELQNVICDKYATVTAVKPGNVPGAPRIGFICHLDTFDCGLCPHVKAQKIRYTGGDVCLNKEKNIWMRLREHAVLNKYVGQDILFSDGTSVLGADDKAAIASVMEMVANLDSSKEKHGDIVICFVPDEEIGLVGAKHLDVKGRFNVDFAYTLDCCELGEMVYECFNAASATIKFTGVSAHPMSAKGVMVNPLLMAVDFISQFNREETPECTELREGYWWFAKMDANSTQARLEAMVREHDLAKYTARKTYMLDVAKKVQAKYPTGKVEIEIEDVYANIANSLKDDFTAIDLLLEAMRKASVKPNIIPMRGGTDGAALSVKGLLTPNFFTGAHNFHSCFEFLPIPSFVKAYEVCHNIVLLGADKRKRTPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB56</accession>
    <accession>E9BE16</accession>
    <name>A0A3Q8IB56_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CGC20_9220</name>
        <name evidence="22" type="ORF">CGC20_9225</name>
        <name evidence="23" type="ORF">CGC21_19490</name>
        <name evidence="24" type="ORF">CGC21_19495</name>
        <name evidence="20" type="ORF">LDBPK_190200</name>
        <name evidence="17" type="ORF">LdCL_190006900</name>
        <name evidence="18" type="ORF">LdCL_190007000</name>
        <name evidence="19" type="ORF">LDHU3_19.0210</name>
    </gene>
    <organism evidence="18 26">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 25" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18 26" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 26">LdCL</strain>
        </source>
    </reference>
    <reference evidence="27" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="28" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860199.1">
        <property type="nucleotide sequence ID" value="XM_003860151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB56"/>
    <dbReference type="SMR" id="A0A3Q8IB56"/>
    <dbReference type="GeneID" id="13386011"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0210"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="269142at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="126"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU78117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU78118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAC5429405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBZ33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP41859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TPP41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP51048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="317" mass="35154" checksum="DC740BF3967AEE78" modified="2019-04-10" version="1">MSANNNSAAAPRKARQDMPKLGFWEEFMISGVAAGAAKTAAAPIERVKLLVQNQGEMIKQGTLDRPYSGVMNCLTRTVKTEGLYALWRGNLSNVIRYFPTQALNFAFKDQFKRMFNYKKDRDGYMKWFMGNMASGGLAGAVSLCFVYSLDYVRTRLANDTKSAKKGGERQYSGMVDCYIKTFKTDGLVGLYRGFCVSCVGIVAYRGFYFGLYDTLQPMLPVDNFIVNFMLGWIVTIVSGLISYPLDTVRRRMMMTSGTGKNYRNSFECFMQCVKNEGAASLFRGAGANILRGVAGALVLSGVDAIKPYYISARAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB62</accession>
    <accession>E9BGK5</accession>
    <name>A0A3Q8IB62_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_231910</name>
        <name evidence="11" type="ORF">LdCL_230026300</name>
        <name evidence="12" type="ORF">LDHU3_23.2510</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861083.1">
        <property type="nucleotide sequence ID" value="XM_003861035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB62"/>
    <dbReference type="GeneID" id="13390521"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2510"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5430324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="775" mass="87702" checksum="775436337A446B0D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBP8</accession>
    <name>A0A3Q8IBP8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-3' exoribonuclease C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_230011500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBP8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0840"/>
    <dbReference type="OrthoDB" id="278118at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF29">
        <property type="entry name" value="EXONUCLEASE XRNC, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="952"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116254" checksum="3020A4727C0F10FF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBW0</accession>
    <name>A0A3Q8IBW0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240015000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1170"/>
    <dbReference type="OrthoDB" id="267051at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1577" mass="165547" checksum="6A7F3FED4C505DB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC46</accession>
    <accession>E9BH97</accession>
    <name>A0A3Q8IC46_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_16750</name>
        <name evidence="10" type="ORF">LDBPK_242360</name>
        <name evidence="9" type="ORF">LdCL_240029200</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861324.1">
        <property type="nucleotide sequence ID" value="XM_003861276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC46"/>
    <dbReference type="GeneID" id="13391484"/>
    <dbReference type="KEGG" id="ldo:LDBPK_242360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2920"/>
    <dbReference type="OMA" id="MDHHCYF"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF458">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="160"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP52355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="278" mass="31586" checksum="6040693233EA4199" modified="2019-04-10" version="1">MTTWEEALTSWGAVYAALFLPAILMLGNFVFGKCFVSEAMCMSQHAPQSVHTRSRILGRAHVALVTLSFAWQYYIVMFVARTKTGGNADARACNPLFFVWDLVDHLPYLRGVQLSLLVQCHSSDVAYLVLVGLFALFYASCVFSVPQVISRSASAEGHDGISYCRRCGSHIKQMDHHCYFIGNCVGDRNRRLFLCCLVTGVANLSYLLYKYALWTLAHGDAITNFGAILVFVFDVFLTALLGFQMFVLRRGWTTREFLRRRRHAKEPVVRFILWLCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICI6</accession>
    <name>A0A3Q8ICI6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250029400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICI6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2840"/>
    <dbReference type="OrthoDB" id="268896at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30234" checksum="D4D5A7F04FD1275C" modified="2019-04-10" version="1">MECLQPCSPVIPTSLFLSFTSLRYLLAPFAHKHIDLCTVTATTDFLPPSSEEWVHLCLLPSASLQLPSRYASFPRSLGAAAVSAALTALVRLFRRRFASRHGAAALPPPLLSQLFSTCLISHPPHRPCWHRQRHMENKAPGTAPRPEGYASAANAQGHENFFRPRQKLGTHNIQRAGLRSARRVGLWFTSSVLVFVVMPAYLGPAYVKYVAGSEWLERASKSIWQRRNEKDFELYMTQRKNTWAEWLGLKRYNISGEENDGDIQKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICL9</accession>
    <name>A0A3Q8ICL9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin family/Cullin protein neddylation domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_160017900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1540"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000035">
        <property type="entry name" value="Cullin_family /Cullin_protein_neddylation_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="727"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1423"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2076"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2200" mass="232942" checksum="9AC7CCA675B2EC78" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICR4</accession>
    <accession>E9BGN9</accession>
    <name>A0A3Q8ICR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dynein intermediate chain 1, axonemal</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Dynein intermediate-chain-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_15815</name>
        <name evidence="14" type="ORF">LDBPK_240270</name>
        <name evidence="13" type="ORF">LdCL_240007600</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861117.1">
        <property type="nucleotide sequence ID" value="XM_003861069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICR4"/>
    <dbReference type="GeneID" id="13390567"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0310"/>
    <dbReference type="OMA" id="VWEDMRA"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000893">
        <property type="entry name" value="Dynein intermediate chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001006">
        <property type="entry name" value="Dynein intermediate chain 1, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP52168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="686" mass="75145" checksum="6E6B4BA315B223D4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE23</accession>
    <accession>E9BIZ3</accession>
    <name>A0A3Q8IE23_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stress responsive A/B Barrel Domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B Barrel Domain, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Stress_responsive_A/B_Barrel_Domain_putative/Pfam:PF07876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_31090</name>
        <name evidence="4" type="ORF">LDBPK_270600</name>
        <name evidence="2" type="ORF">LdCL_270012500</name>
        <name evidence="3" type="ORF">LDHU3_27.0980</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861916.1">
        <property type="nucleotide sequence ID" value="XM_003861868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE23"/>
    <dbReference type="SMR" id="A0A3Q8IE23"/>
    <dbReference type="GeneID" id="13389176"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0980"/>
    <dbReference type="OMA" id="IMSAKNI"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832">
        <property type="entry name" value="BLL2683 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37832:SF1">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="110" mass="12312" checksum="FAE7F2A02861FE47" modified="2019-04-10" version="1">MLHVVLFKTDAKKLAKEFPGNSLEEAIESLRQAKIPGLVDFNIRPKNTSPWPGYQDDSQGYTHALMSSHVSASALRTYAEHPVHKVLQARLLKCVTAPPLRMDLDIHPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFG6</accession>
    <accession>E9BHZ1</accession>
    <name>A0A3Q8IFG6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_26155</name>
        <name evidence="6" type="ORF">CGC21_9155</name>
        <name evidence="5" type="ORF">LDBPK_252370</name>
        <name evidence="3" type="ORF">LdCL_250029500</name>
        <name evidence="4" type="ORF">LDHU3_25.2850</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861567.1">
        <property type="nucleotide sequence ID" value="XM_003861519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFG6"/>
    <dbReference type="SMR" id="A0A3Q8IFG6"/>
    <dbReference type="GeneID" id="13388813"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2850"/>
    <dbReference type="OMA" id="ASVWENW"/>
    <dbReference type="OrthoDB" id="269633at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP40833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP48812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="123" mass="13946" checksum="49AC58CDBB12A815" modified="2019-04-10" version="1">MERERKLAEREVREAVADAESPLAQRHVRESLKKNKFAVALYAVALFTPAFFLMFFYTAKAREIRANFRDPYALPEGFDPKTGEFSSKEAQPKSAQELPISRSLFVGEEPGSYGGRARKRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFU3</accession>
    <accession>E9BRF0</accession>
    <name>A0A3Q8IFU3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_27065</name>
        <name evidence="3" type="ORF">LDBPK_343520</name>
        <name evidence="2" type="ORF">LdCL_340044600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864511.1">
        <property type="nucleotide sequence ID" value="XM_003864463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFU3"/>
    <dbReference type="GeneID" id="13387390"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340044600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5760"/>
    <dbReference type="OMA" id="TLIRWRL"/>
    <dbReference type="OrthoDB" id="265928at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="348" mass="41234" checksum="DE4EF45FCD50C8BA" modified="2019-04-10" version="1">MHLAGTSCVRQRGAYFSTPELSSSSHNERSSSAWPTGSPPQRHTHASTPVATYMHAPSRDVAFGGRAHVATHRSRDTLTAELQRIRAEANTIVVERWFWRWGLYAVRRAALRRIQHRARLVLWSRVGARCFAWWRLVAQRRLCREVLYREAAARERATLIEGLCRVAWDKWRQWARVRARQCARAAHLGLVNRQRHALLRFRAWTCHPRRCHQLRSVEQIRFSAERSLARFTLIRWRLHALESYLAFPLQVRAAQQVATAAFRAWQRRALIGASMRLIRHEALLHVAERCFDRWRRWLRRRLQAALLREANEARLVLRIFSQWAWHHELHALDYEQYVAERHLPRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG26</accession>
    <name>A0A3Q8IG26_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360027500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG26"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2830"/>
    <dbReference type="OrthoDB" id="10267663at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="entry name" value="Protein of unknown function UPF0759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348:SF4">
        <property type="entry name" value="DUF72 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YECE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="TM1631-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="506" mass="55438" checksum="077D2A30213AC0FE" modified="2019-04-10" version="1">MLGAQSAPSFLPASALSSSAPQCPPPQQLIERRPHDSLVQHSPYGPSRNTTYGWGNPFRPPMTATVPSHPCIHIGISSLNGVPTVGQSDRSMRSLLTQYRKKFNCLEHCYPYHKVGDEGTWKTWADMVRNSNAADGGRIHSLKTVSAPPLHTVEGAAAADVASAGATPLCPLTVNANRFLYTIKANNLLTHVKQLQMDDADVLAHVQVFFQERCPLLEPFLGPVLVQLPPSFGYSPENVQRLTRLHQLLSQEEVLLLETRSVSPKAFSSSGTSSTTAPSSSAPRRQRRLRVAVEFRSRSWYRDETFALLRSFRWALVVAHHHDDPTYSQVVDTGAGFLYVRLHGPLGRNVGDYGPLAMRLWAEKMVQYLRSERSPAEGSPTSALPDETTREVFIFLNNSDSNVGGTTSSVVDATCLAEQMRNLLQCKSSRPPPAETAAASPSPRVSADPQLVMARVEAKTPMAVPEDDCRASCAQHVQDEADTPPPKRQCTAQRSSGTREDEVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG41</accession>
    <name>A0A3Q8IG41_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_240014900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG41"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1160"/>
    <dbReference type="OrthoDB" id="244690at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="764" mass="79824" checksum="89C7D8AFA894688D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG75</accession>
    <name>A0A3Q8IG75_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radial spoke protein 3 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Radial spoke protein 3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Radial_spoke_protein_3_putative/GeneDB:LmjF.27.05 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_33120</name>
        <name evidence="13" type="ORF">CGC21_31210</name>
        <name evidence="10" type="ORF">LdCL_270010100</name>
        <name evidence="11" type="ORF">LDHU3_27.0690</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG75"/>
    <dbReference type="SMR" id="A0A3Q8IG75"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0690"/>
    <dbReference type="OrthoDB" id="313308at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5431162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="358" mass="42119" checksum="7356D2D335A4DED8" modified="2019-04-10" version="1">MQRQVADSEVTVAAYTFRQPPQGFQEPKYRDPSSSRNASRYMHSGSQRYGNIMYDRRVYRGNTYASPIMSIAARAEMEKREMIDTQRRKQASQRAASIKRRKQLEAARRHMATPDPGEGRYNTQIQTDEYLEELTDKVDQQVQETQTDPLMDRPVTPKYVPIKSGRDAETQIHEGDLFRFDEAVEPILEVLVGKTLEQAMLEVMQEEELELLRQQQIEFEQRRKEELLETQKLEAEERRKFEEKERRKKQEMERIQREKETREKLQARQFAKVYMSNMENRVFSRLQDEGWFADRVLNEVELDFFPWLMTEVDRELAKKTKARALVDELIRDVVRLNASQLEKSRAAAAAAGEGPVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGC7</accession>
    <name>A0A3Q8IGC7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310020900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGC7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2280"/>
    <dbReference type="OrthoDB" id="265959at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129694" checksum="C95EA2DD5F0FD29F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGH8</accession>
    <name>A0A3Q8IGH8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin/FtsZ family, GTPase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_330014500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGH8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330014500"/>
    <dbReference type="OrthoDB" id="670568at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000015">
        <property type="entry name" value="Tubulin beta class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15938" checksum="3D60F124EB660910" modified="2019-04-10" version="1">MGTLLISKLREEYPDRIMMTFSVIPSPACRIPLWSPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYAACPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH92</accession>
    <name>A0A3Q8IH92_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_100016700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH92"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100016700"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30379" checksum="D68309A8C5B8AD9F" modified="2019-04-10" version="1">MQRGQHRRLAWVGILFFLVVSLIALCCAVYLRPLSRLTEFIYFPLLQAVVHMCSLVFLVAWNFGSAAVPLVVWVILPIALMGVPAIALVVVTVLSRHEERRRDDLLQRRLVLGVTAAYVMSGAWEQQAQSSSPTQLQPGDSEARVGRQRQRAAAVSADGKPEDAGGGQRWRSNAAMRLREHSTGPSLLQRQSPGVGSCSGHLDCHRCKGGGTPATRQPQYRLPRPHTRGHGIEPCRPVGSPPEAGSRKAPIAVVANPRRHRALVLAFDELRLQRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHB9</accession>
    <name>A0A3Q8IHB9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340032300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4050"/>
    <dbReference type="OrthoDB" id="264898at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1366" mass="144052" checksum="BC3D044E432A4DDD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHU8</accession>
    <name>A0A3Q8IHU8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_120019700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHU8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1540"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="877" mass="89469" checksum="B4830B4968D7EC1D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHY7</accession>
    <name>A0A3Q8IHY7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_340013700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHY7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1330"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="75"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="254" mass="29136" checksum="CA0933A4E67BDD24" modified="2019-04-10" version="1">MSQPMLLEIRPPVRVCGDTHGQYYDLLRIFEKCGFPPYSNYLFLGDYVDRGKQSVETIVLQFCYKIVYPENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLTDLTAINEILRPCDVPDRGILCDLLWADPENEVRGFLESDRGVSYLFGEDIVNDFLDMVDIDLIVRAHQVVQRGYEFFASRQLVTVFSAPNYCGEFDNDAAVMTIDDKLQCSFLIIPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIV0</accession>
    <accession>E9BKX8</accession>
    <name>A0A3Q8IIV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_28405</name>
        <name evidence="4" type="ORF">LDBPK_291800</name>
        <name evidence="3" type="ORF">LdCL_290023600</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862599.1">
        <property type="nucleotide sequence ID" value="XM_003862551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIV0"/>
    <dbReference type="GeneID" id="13387335"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2590"/>
    <dbReference type="OMA" id="VQWRELM"/>
    <dbReference type="OrthoDB" id="247938at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="269" mass="30044" checksum="9A08D5B44EB862D1" modified="2019-04-10" version="1">MATLTEDEIAPSAIAAERERLQEATQHVAQLERRLDALQRELEAARTRREQLLLSVQWRELMAAVNADEEVYAVAERMMDAFAAFRESLVEPENYLREQREEALNEDDIVPYSDTDDYADFSGVETVVEELLAAVKEQLESHAAAPPSSFRQSKHSSLGGSFASDEKPNHPAGESVEAHKVNADARRQALLKLLVITVLMGRVEQYCRFKSISDASNVPQSDAEEMRDGVASVWQWLFHEQPGVLTAEEGAEWKHIAGSFLGDSYTVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJB3</accession>
    <accession>E9BNW2</accession>
    <name>A0A3Q8IJB3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_34350</name>
        <name evidence="5" type="ORF">CGC21_20595</name>
        <name evidence="4" type="ORF">LDBPK_322100</name>
        <name evidence="2" type="ORF">LdCL_320026400</name>
        <name evidence="3" type="ORF">LDHU3_32.2610</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863624.1">
        <property type="nucleotide sequence ID" value="XM_003863576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJB3"/>
    <dbReference type="SMR" id="A0A3Q8IJB3"/>
    <dbReference type="GeneID" id="13390912"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2610"/>
    <dbReference type="OMA" id="CEEAMCE"/>
    <dbReference type="OrthoDB" id="267566at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="148" mass="16449" checksum="E164647A3902DBB7" modified="2019-04-10" version="1">MPKKHRVKRQNYVAHLRNLEKERETYLQKRRAHKRSRETGNEEVMGEARDRMEAGAPKKRRTEADASTAASARNEEGAAPHTHLSLTTSAKSAAAAETVPAKRRSFSTKSFAELVKASTATAQTTDAAPRDTSAITTTAKKTLKRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJS9</accession>
    <name>A0A3Q8IJS9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPRY domain/HECT-domain (Ubiquitin-transferase), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_320046800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5250"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000089">
        <property type="entry name" value="Dual specificity protein kinase splA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000067">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="1475"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="1847"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="3363"/>
            <end position="3570"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="3766"/>
            <end position="4087"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="4055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4087" mass="454273" checksum="33388692E0E6408D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK06</accession>
    <name>A0A3Q8IK06_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360020700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK06"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1950"/>
    <dbReference type="OrthoDB" id="267336at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="654" mass="68780" checksum="16A6EA2A76F11147" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL33</accession>
    <name>A0A3Q8IL33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">NADH dehydrogenase, putative</fullName>
            <ecNumber evidence="18">1.6.99.3</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="19">NADH_dehydrogenase_putative/GeneDB:LmjF.36.5380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LdCL_360063600</name>
        <name evidence="19" type="ORF">LDHU3_36.7490</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="18"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL33"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360063600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7490"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000009">
        <property type="entry name" value="Internal alternative NAD(P)H-ubiquinone oxidoreductase A1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="13"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="17">
        <location>
            <begin position="370"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="460"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAC5435141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="527" mass="57477" checksum="E64590A407EB5B13" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL95</accession>
    <accession>E9BFI4</accession>
    <name>A0A3Q8IL95_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial RNA binding complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_34605</name>
        <name evidence="3" type="ORF">LDBPK_211980</name>
        <name evidence="2" type="ORF">LdCL_210025500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860715.1">
        <property type="nucleotide sequence ID" value="XM_003860667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL95"/>
    <dbReference type="GeneID" id="13386471"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2370"/>
    <dbReference type="OMA" id="LKKGWTH"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001596">
        <property type="entry name" value="Mitochondrial RNA binding complex 1 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="340" mass="39611" checksum="6CDD86DAAAC6C16F" modified="2019-04-10" version="1">MLRRTEIALKKGWTHNPGRTRRGGKNLAWRPKISDAKLSQFVPLALVHPRRHPNNWQERQFNALGYTKWPKDIGFYNAGDNFEVTPEAAWRLYVHARDEPYWGKLHCEKTIITLLPVVEKAPKENMERVLDVFRHYLKRYGADHYIYNAVMQAAAFAKNYEQTEQLFKEMETLGLEPNAQSYVNMMLAAKLCGLPPEKSEAYFKRAVKDGAMQSVMRMDTEFRMWMDQLDRLGSFTASSGYLSVNEEGAKPMPRDMWAIWGWHRSESKFISRHDLIMQQVRARVHSGKELTGTVYTKTRRQPWAKFNGMLRHDYNGPSYRAPTTFPDAPEYTNEAGHKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILL5</accession>
    <name>A0A3Q8ILL5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear pore complex protein (NUP155), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_360084800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360084800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9600"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1780:FF:000013">
        <property type="entry name" value="Nuclear pore complex protein (NUP155), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.450:FF:000006">
        <property type="entry name" value="Putative nuclear pore complex protein (NUP155)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="763"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU84128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1306" mass="143696" checksum="864FD634B3267A32" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILV7</accession>
    <accession>E9BV02</accession>
    <name>A0A3Q8ILV7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_19055</name>
        <name evidence="4" type="ORF">CGC21_15480</name>
        <name evidence="3" type="ORF">LDBPK_366450</name>
        <name evidence="1" type="ORF">LdCL_360072000</name>
        <name evidence="2" type="ORF">LDHU3_36.8550</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865757.1">
        <property type="nucleotide sequence ID" value="XM_003865709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILV7"/>
    <dbReference type="SMR" id="A0A3Q8ILV7"/>
    <dbReference type="GeneID" id="13386611"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360072000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8550"/>
    <dbReference type="OMA" id="HLENRGM"/>
    <dbReference type="OrthoDB" id="275834at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5435225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="185" mass="21160" checksum="ADC28221FD3D3B8F" modified="2019-04-10" version="1">MVLNKWAAVTKSAPPAAGLRPLARTVSPNPKLRPADYKVPYVLRTFIKDRHSSEMQHIENRGMYREELAIERSRFPRMQKTLTIQTDGSLNEREFEFAVPPVVMLFQDRLSAHRQRQVALAKIGKLKRAKSWEMAVRGKESLNPVCNALVFPYCVPKKMLVRPRTVDPLSAKSMADNRKSRDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM89</accession>
    <accession>E9BS89</accession>
    <name>A0A3Q8IM89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_6605</name>
        <name evidence="4" type="ORF">LDBPK_352190</name>
        <name evidence="3" type="ORF">LdCL_350026800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864798.1">
        <property type="nucleotide sequence ID" value="XM_003864750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM89"/>
    <dbReference type="GeneID" id="13387676"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2800"/>
    <dbReference type="OMA" id="QTTSMLR"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF284">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="440" mass="48405" checksum="A3E67A53A8D61858" modified="2019-04-10" version="1">MKLGYKSETSAFFVGAATFAACFFIPRRFLAAAIPLWIVASRLLARGAVNHARPVTDADTADKQAQARFVMSRDMPLAKRPVAIVTGTNSGIGYWTAVGLAVEGYEVVVTCRSAVLTQQTAERIQQEAKRRRRAQPKLYEHSPASVLVEGHLPVECDDFDSVRAFAEWVARKYAQRNVQVLVNNAGGMRKALGFSRLHPNLELHTAMNFLGPFLLTELLLPVLERNGGRVVYVSSEAHRFAQSLLLPGRFSVWRSIRAFPTCNGLIAGKLLNALKEVNQGAGKSSGPLQTSSTQHAFGRYGISKLLNTYHAHMIARRYRDVKDEAHRVYACSLHPGCVATNFSRDIMGGFVRMILSWASLLFLKTAEEGAQTTLHCAMCPRTELELVSPSGEKPTTNADAVSPYFVECADQTTSMLRAYGWDVSEAAAILQWGRQQVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IU97</accession>
    <name>A0A3Q8IU97_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330037600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IU97"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330037600"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21763" checksum="896241B9A2FA539C" modified="2019-04-10" version="1">MVNHRHYYTYDASAKRLPCTYVFPTGYCYRRTPSASFCGITCKIIIGSVLGGLALLCLAVLVVYHFRRRKTTQQPSTEVAHISSTNQPGPAQTVPPPQQPMFGGRDYAGAAGYDRASLPMPPAFPGNGVAPLGHVSNTYVPAPTGYGYQPYPPQLGYPLATTQATDGVYVGGATYYARARAAEDTAAAFSASSSGYPHPEKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVZ2</accession>
    <accession>E9BTS3</accession>
    <name>A0A3Q8IVZ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperonin HSP60, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">groEL protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_28895</name>
        <name evidence="15" type="ORF">CGC21_13355</name>
        <name evidence="13" type="ORF">LDBPK_362140</name>
        <name evidence="11" type="ORF">LdCL_360027100</name>
        <name evidence="12" type="ORF">LDHU3_36.2780</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865329.1">
        <property type="nucleotide sequence ID" value="XM_003865281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVZ2"/>
    <dbReference type="GeneID" id="13388215"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2780"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ38652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="562" mass="59342" checksum="A8C1FDB2963A65CF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Y8</accession>
    <name>A0A3S5H4Y8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycan beta 1,2 arabinosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_020007300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4Y8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0290"/>
    <dbReference type="OrthoDB" id="262657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018536220" evidence="1">
        <location>
            <begin position="17"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="414" mass="45397" checksum="599F25C4B8BFF3D3" modified="2019-04-10" version="1">MLVSCITIMYLLCTLQFLIVEPDVSRENAAVSGHETRTNISSPAIRLMANELELPPIRVMAADHACAVCTNGVVYAQTGEEGGPAAAASRPDNVTAMVCRKVLKEQVDVLTSVEECVARLHRLGMLHAVATREEDVNASCVRVTVPAIVGRMSGGSDSCPAFLAEIRPGIDKHAKLQVWFPRMPSWPLPGSRALPYVGTAAVRDTDVDRDVAPPASLEITSDGSTIVLRFGRDTTSTVPEAFELRCPTHFFSVLVGRWGRQHNQLQELLHGLAFARASNRTYVLPSFTPDTSLPYVRYDASSLYGFNAIRREGRYCLVTNAEVKLIFAQLQAMGVVMDMRRVDYIGVVKPPLSPPHRWRRRESAGGGCCHRCATACASTTSRAGLPTRGRPRLRCTPWRTTALTRCCSASLWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H569</accession>
    <accession>E9B7W3</accession>
    <name>A0A3S5H569_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Multicopper oxidase, putative</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Multicopper_oxidase_putative/Pfam:PF07732/Pfam:PF 07731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_27245</name>
        <name evidence="11" type="ORF">CGC21_30075</name>
        <name evidence="10" type="ORF">LDBPK_030930</name>
        <name evidence="8" type="ORF">LdCL_030014600</name>
        <name evidence="9" type="ORF">LDHU3_03.1040</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000043">
        <property type="protein sequence ID" value="TPP45037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000061">
        <property type="protein sequence ID" value="TPP52923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858060.1">
        <property type="nucleotide sequence ID" value="XM_003858012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H569"/>
    <dbReference type="GeneID" id="13390669"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.1040"/>
    <dbReference type="OMA" id="RTRYERY"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13853">
        <property type="entry name" value="CuRO_1_Tth-MCO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF2">
        <property type="entry name" value="MULTICOPPER OXIDASE LPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600558" evidence="5">
        <location>
            <begin position="24"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="415"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP52923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="635" mass="71106" checksum="0C83A38236AC39B0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H581</accession>
    <name>A0A3S5H581_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040006800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H581"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0200"/>
    <dbReference type="OrthoDB" id="264685at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018761694" description="Surface antigen-like protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="53426" checksum="181F585B737642DF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5N6</accession>
    <accession>E9B8M9</accession>
    <name>A0A3S5H5N6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_060180</name>
        <name evidence="8" type="ORF">LdCL_060006700</name>
        <name evidence="9" type="ORF">LDHU3_06.0220</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858326.1">
        <property type="nucleotide sequence ID" value="XM_003858278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5N6"/>
    <dbReference type="GeneID" id="13391711"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0220"/>
    <dbReference type="OMA" id="QEEFFDM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="74"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="662" mass="69696" checksum="F7CCA5DEE424E3D4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5R9</accession>
    <accession>E9B8T0</accession>
    <name>A0A3S5H5R9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_24240</name>
        <name evidence="3" type="ORF">LDBPK_060700</name>
        <name evidence="2" type="ORF">LdCL_060012100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858376.1">
        <property type="nucleotide sequence ID" value="XM_003858328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5R9"/>
    <dbReference type="GeneID" id="13391669"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0820"/>
    <dbReference type="OMA" id="MLTSFRW"/>
    <dbReference type="OrthoDB" id="271070at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="243" mass="27439" checksum="2D6B74DE8A96451B" modified="2019-04-10" version="1">MGTKGSKAVSSSSAVPAAATTTGDNKGTSNWWDGAVSDASDADLGLTPDVSLSSDISTPEENAAKRKAYAHLKSPYARHRPAASMKGRGSSGNNGAEASANAHVNLIEQIYNEDFETIDHIQALRLPPMVARQLQNTVRDEAERHCAEVEKTMARCLQDKMWTSWKCQKERDTYYHCVEEIEQRNLRPDPTNPHWVDMLTSFRWKYNLGVFHGEIMGRNNIMKEIWREHYPDRELPHPWVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H622</accession>
    <accession>E9B9B8</accession>
    <name>A0A3S5H622_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_10620</name>
        <name evidence="3" type="ORF">LDBPK_071310</name>
        <name evidence="2" type="ORF">LdCL_070018100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858562.1">
        <property type="nucleotide sequence ID" value="XM_003858514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H622"/>
    <dbReference type="GeneID" id="13391896"/>
    <dbReference type="KEGG" id="ldo:LDBPK_071310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_071310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1550"/>
    <dbReference type="OMA" id="HAIQFFT"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63859" checksum="9986A3D8A8D2EADF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H624</accession>
    <name>A0A3S5H624_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_080005100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H624"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0030"/>
    <dbReference type="OrthoDB" id="270273at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30424" checksum="B2E72C2332FB248F" modified="2019-04-10" version="1">MSEFFWDVGREEGSLQGPLLNAPRKRCREENYAVDAYPRHLPPHVRVQVAWENITTLVSLRGHVLDAHGRFNSAEFPGLAFFYNPVVACVASGTVTLHFDNSTSVTERILREERPLPCPIHGPFRCPCHIMHEAAGGVAQLLGEIFCQHSPFDVSIDCHRPYPHICIDSQSRTWSVSLVGLPLPPKSFGPFPLGDITSPQSIKNYWFQYIEKSRAAEDACIMCGVVSGIHCSRCMCRLCKRCGEHCANCWSYVCRGCSTAGENGTTICYNCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H670</accession>
    <accession>E9B9I2</accession>
    <name>A0A3S5H670_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_23035</name>
        <name evidence="5" type="ORF">CGC21_0175</name>
        <name evidence="4" type="ORF">LDBPK_080800</name>
        <name evidence="2" type="ORF">LdCL_080013300</name>
        <name evidence="3" type="ORF">LDHU3_08.1140</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858642.1">
        <property type="nucleotide sequence ID" value="XM_003858594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H670"/>
    <dbReference type="GeneID" id="13391932"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1140"/>
    <dbReference type="OMA" id="ESPFRMM"/>
    <dbReference type="OrthoDB" id="273637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="290" mass="32619" checksum="F13033C0FE4D7ED5" modified="2019-04-10" version="1">MPDDRRRSSRTDGALVAHRPDDSASPVERRMRVDPRTHTKSLYQRGPDGSEMYASYYNSNDDPTFQERFNRHNNGNAFVQSAQFTYVSHGCGGGRNPGVVKERQRPVVVEEPVGADKHEASTDSGNNANVYANHRDKEKRRTSKQDPIVEEPDGENDYNDADSRAHRRSGKKGERSSHPDALEFWRDPWGMESMMAEMMQPPLGFGDAFPFTSRRAPAQGRQKSPSASDESKWQLSPYSRGGVMGGPFTGDFFGTGGPESPFRMMEAMQYHMHKQRAAMFGGVDPFARFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Y4</accession>
    <accession>E9BCX3</accession>
    <name>A0A3S5H6Y4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_36775</name>
        <name evidence="6" type="ORF">CGC21_24805</name>
        <name evidence="4" type="ORF">LDBPK_161190</name>
        <name evidence="2" type="ORF">LdCL_160017100</name>
        <name evidence="3" type="ORF">LDHU3_16.1460</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP41004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859806.1">
        <property type="nucleotide sequence ID" value="XM_003859758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Y4"/>
    <dbReference type="GeneID" id="13393204"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1460"/>
    <dbReference type="OMA" id="QMLFINE"/>
    <dbReference type="OrthoDB" id="264696at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="117" mass="12740" checksum="80698DDB226B89BF" modified="2019-04-10" version="1">MADVQLKALLTGVEAERGATVTCRDPSALEMLLRISNSDANRGSVSVFFQNTSAASSPAAQMLFINEKYAKSVEEEVQLWLDPFKTTAVEVTAGSERKRARADSESDDFESEMDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H719</accession>
    <accession>E9BDG9</accession>
    <name>A0A3S5H719_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-gulonolactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_171470</name>
        <name evidence="8" type="ORF">LdCL_170020900</name>
        <name evidence="9" type="ORF">LDHU3_17.2000</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32363"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17587"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="EC" id="1.1.3.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860002.1">
        <property type="nucleotide sequence ID" value="XM_003859954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H719"/>
    <dbReference type="GeneID" id="13393282"/>
    <dbReference type="KEGG" id="ldo:LDBPK_171470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.2000"/>
    <dbReference type="OMA" id="KQWANEW"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050105">
        <property type="term" value="F:L-gulonolactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000033">
        <property type="entry name" value="L-gulonolactone oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000027">
        <property type="entry name" value="L-gulonolactone oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2520:FF:000005">
        <property type="entry name" value="L-gulonolactone oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5429200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="495" mass="55410" checksum="338A7BE4BE1F1E5E" modified="2019-04-10" version="1">MSAQSAASRWTNLAGIGSCHPTHHHYPTSTEEVQDAVELVRSQNGKCRVAGAGKSPNTATFTNEHLIHMERMNRILSIDTVAHTITCEAGAVMEEVMRSVDKVGLMVRCVPSYVRTTVGGCIATATHSSGSQCHCLSDYVRGLKIVDGCAQIRTLVAGKDDAELRLAACHLGVIGIVTEVTLEVQPRVQWKLVSQPLPMKDATNAALVAEKVRSTEYYRWWWVPHTDGCYESYGRVESTTDISALPPLPDALTARDDAPVQPSPAALQEASSASDSSASLIVKSALKSIATDFVRHQVVEWSLWAACLYPAIQPYVNKAYQRVFFSAPQVQRGSALECFTFDCLFKQWANEWAIDASRAVEAFNRLRDMIDREGMLLHFPVEFRFTAPDVSDMSPAVGRPTCWIGVVMYRPYGQEARDTRRCYDGFCHVMEEMGGRPHWAKYYDWGHREITAAYGDHWERFLALRRRMDPDDIFVNRWFRNLMSSDRVNSTACTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H747</accession>
    <accession>E9BDZ0</accession>
    <name>A0A3S5H747_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinesin motor domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Kinesin, putative</fullName>
            <ecNumber evidence="4">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_5455</name>
        <name evidence="5" type="ORF">LDBPK_181590</name>
        <name evidence="4" type="ORF">LdCL_180021200</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000025">
        <property type="protein sequence ID" value="TPP50601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860173.1">
        <property type="nucleotide sequence ID" value="XM_003860125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H747"/>
    <dbReference type="GeneID" id="13393461"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.2030"/>
    <dbReference type="OMA" id="EYHPTAM"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000169">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF929">
        <property type="entry name" value="KINESIN-LIKE PROTEIN AT 31E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="796" mass="86398" checksum="E8A7BD0ACB629A42" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H791</accession>
    <accession>E9BEW8</accession>
    <name>A0A3S5H791_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_29025</name>
        <name evidence="9" type="ORF">LDBPK_201700</name>
        <name evidence="8" type="ORF">LdCL_200021800</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860510.1">
        <property type="nucleotide sequence ID" value="XM_003860462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H791"/>
    <dbReference type="GeneID" id="13386296"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2070"/>
    <dbReference type="OMA" id="KCTAFQE"/>
    <dbReference type="OrthoDB" id="6142248at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1810">
        <property type="entry name" value="RNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012647">
        <property type="entry name" value="RNA_lig_RNL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040609">
        <property type="entry name" value="Rnl2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02307">
        <property type="entry name" value="RNA_lig_RNL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18043">
        <property type="entry name" value="T4_Rnl2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RNA ligase 2 C-terminal" evidence="7">
        <location>
            <begin position="318"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP49839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="418" mass="47758" checksum="EDDB4A35AACF0BF6" modified="2019-04-10" version="1">MFRRCLLTRLVRRSLVLFSDEKEALFERYSEIENAHSRRIEALKDAGLFNDEWIATEKVHGANFGIYSTEHGKTIQYAKRSGIMPPYEHFFGYHILIPDLVRYVKQGRELLTEQLGMSPSTVIINGELFGGKYDHPSVPKRRQNVMVAGRPRTITAVQNNAFPQYCPDLHFYAFDIKYRRTEEEEYCTMTYDQALAIFEKISGLLYAKAIIRGPLSKVAAFDVENFVTTIPPLVGMGDYPLKGNWAEGLVVKHCRRGEPGFDAKGLTIMKFKCTAFQEISTDRRQGPRVDALEEVRRQSIKVSGVQLPDMESVIRDPEVRQATHHLLDHVCENRLQSVLSKIGTGPFETQSMTPTELSTLLAKDALKDFLKEADAKIVNTPLLVRREMARYVLFEARRYVASRWKDVVGQQREADGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7V1</accession>
    <name>A0A3S5H7V1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330033000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7V1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3690"/>
    <dbReference type="OrthoDB" id="272403at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1051" mass="114433" checksum="F169977CE56227A3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H809</accession>
    <accession>E9BT15</accession>
    <name>A0A3S5H809_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_14315</name>
        <name evidence="5" type="ORF">CGC21_7890</name>
        <name evidence="4" type="ORF">LDBPK_354960</name>
        <name evidence="2" type="ORF">LdCL_350054600</name>
        <name evidence="3" type="ORF">LDHU3_35.6490</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865073.1">
        <property type="nucleotide sequence ID" value="XM_003865025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H809"/>
    <dbReference type="SMR" id="A0A3S5H809"/>
    <dbReference type="GeneID" id="13387951"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350054600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6490"/>
    <dbReference type="OMA" id="HQGVKAM"/>
    <dbReference type="OrthoDB" id="271768at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="153" mass="17538" checksum="188873F0DAD39882" modified="2019-04-10" version="1">MMRSSEKHQSVKAMQLNRDRIKERIQEKHQLQRQRVRDRRLSGLRKAEDGETSGDATGAGILWAPVKGHEEVGSSSAYAPDTALCCNPGGTVTMPAVEDWSDIGHEFGVNIHDVDVMEYLLTLEEEIRQEQFFQFYDQTNGNEWEDYFRSLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP37</accession>
    <name>A0A3S7WP37_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050009400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP37"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0510"/>
    <dbReference type="OrthoDB" id="273355at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="846" mass="91210" checksum="67F5DBE02CE17AB5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ31</accession>
    <accession>E9B9M5</accession>
    <name>A0A3S7WQ31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_080050</name>
        <name evidence="2" type="ORF">LdCL_080005400</name>
        <name evidence="3" type="ORF">LDHU3_08.0060</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858570.1">
        <property type="nucleotide sequence ID" value="XM_003858522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ31"/>
    <dbReference type="SMR" id="A0A3S7WQ31"/>
    <dbReference type="GeneID" id="13391903"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0060"/>
    <dbReference type="OMA" id="RAKMQPI"/>
    <dbReference type="OrthoDB" id="270821at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8539" checksum="C023F7320D03C6F2" modified="2019-05-08" version="1">MASIKELNDRLTKQPYVSGYTPSADDAKLFNEIFGDNVNVVQWAARMATYYPSERSKMKPIPVESEDSSEIDYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQC4</accession>
    <accession>E9B9J5</accession>
    <name>A0A3S7WQC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DnaJ_domain_containing_protein_putative/Pfam:PF00 226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_080930</name>
        <name evidence="3" type="ORF">LdCL_080014800</name>
        <name evidence="4" type="ORF">LDHU3_08.1280</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858655.1">
        <property type="nucleotide sequence ID" value="XM_003858607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQC4"/>
    <dbReference type="GeneID" id="13391937"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1280"/>
    <dbReference type="OMA" id="RQRKEWN"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="326" mass="36399" checksum="E611A598B9A62EE0" modified="2019-05-08" version="1">MSEAQQAAEIARLMACEARKASPFEFLQLDIATCELTDVNRQYRKIALLLHPDKCQLANAADAFHVAEKVHKSLSQESIFYHLKRAYRKQQDRLAEEGTSGTGAGSRTIPAAGAAAGQKRAREAETALPPIAFGSLTQLAASGLSSDAQKAAEIRRVLQCKATDYFIILDVDPSNCTVADVDRRYRKMAQALHPDKCQLPHVQDAFTVFETAHKELADEKKLVRFKVAFEQQRKKEAALKAAAAQRGVSGSGGDADRFGSEESMTAEERLQKRRMEALRDQQLEAARLGEEAARRRKLKEEKEKEETALAAELERQRKEWNDLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR60</accession>
    <name>A0A3S7WR60_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LdCL_100011400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR60"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0740"/>
    <dbReference type="OrthoDB" id="265814at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000003">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="17">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="599" mass="63723" checksum="8222832D2DCEFC6C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRX5</accession>
    <accession>E9BB30</accession>
    <name>A0A3S7WRX5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_27530</name>
        <name evidence="2" type="ORF">LDBPK_120500</name>
        <name evidence="1" type="ORF">LdCL_120010700</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000046">
        <property type="protein sequence ID" value="TPP53927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859167.1">
        <property type="nucleotide sequence ID" value="XM_003859119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRX5"/>
    <dbReference type="GeneID" id="13390184"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0760"/>
    <dbReference type="OMA" id="MKWVQLP"/>
    <dbReference type="OrthoDB" id="271674at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="167" mass="17869" checksum="7EF35E882B8D8586" modified="2019-05-08" version="1">MHRTATRCFFSSFTRGFSKGFWKEFGGAPGGLGGSSGSGGASLFARKGGSSGSNGGNIFGGFGGGSGFPPGGPLGGFLNKALEWCSESHARDIAREMGVDLRDIRFDKTPEGGINVMVDAPKATPLQIEQLGKRVQEECPVARFRKTQVNSPKHEMKWVQLPPRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT03</accession>
    <name>A0A3S7WT03_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_140012600</name>
        <name evidence="15" type="ORF">LdCL_140012700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT03"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0960"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="299" mass="34692" checksum="0855B56547CDE7D5" modified="2019-05-08" version="1">MVQLLESFRGDNVCQWMADHIEVPVLIVGLYMVMVLYIPDAYMKNREPFNLRQLNMAWNLLLTVFSICGAYYCLPQLYRTIFVPEFTVHDYTNGGHIQWKGGVYNAFCYWNNNIFYDGPVGAFVCLFILSKIPEMLDTAFLVFQKKPVIFLHWYHHVTVMLYCWHAYMYNISGGLVFAGMNYGVHSIMYFYYFICSCGYRKYVRPFASFITFLQIAQMVVGMFTEVYTLSILYFTNRRCDSNAANARLGFMMYLSYFILFSKLFYDSYLKPAPPHSAAAKHNDATAVPNGEPAAVKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTA3</accession>
    <name>A0A3S7WTA3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_150006700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTA3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0250"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="362"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="745" mass="80402" checksum="DD0F3D780FE1FD54" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTR3</accession>
    <name>A0A3S7WTR3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Holliday junction DNA helicase ruvB N-terminus/Part of AAA domain/AAA domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_160005200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTR3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0030"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22981">
        <property type="entry name" value="DD_TbAK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="214" mass="22918" checksum="373796E08BD871DF" modified="2019-05-08" version="1">MSTGTISAAALQYFESKGIQSILDEAMHNLVLKMPADPLLFLEEAFRRPTPLHIIITGPPGSGKTTLAAKLAAHYGITHVAATSAAAGDMAMPAGVLGELKTLQKDGKGWVLDGFPQTRADAIQLQTSGIFPQQVFELQVPLAVALERAIFTAADPSKNTEEATAIAKNYEHYDVRRIEVTTSYQHCYRGIDATVSAEEVAAEALKAIDALQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVI1</accession>
    <name>A0A3S7WVI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_190015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVI1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1260"/>
    <dbReference type="OrthoDB" id="267993at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1234" mass="126734" checksum="EA1F535D410CF139" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW80</accession>
    <name>A0A3S7WW80_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase, putative</fullName>
            <ecNumber evidence="4">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_200022300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW80"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2130"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08021">
        <property type="entry name" value="M20_Acy1_YhaA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="337"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="542" mass="59561" checksum="949B3280BC9017C2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW83</accession>
    <name>A0A3S7WW83_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_210006600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW83"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0180"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01028">
        <property type="entry name" value="TOPRIM_TopoIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000005">
        <property type="entry name" value="DNA topoisomerase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000008">
        <property type="entry name" value="DNA topoisomerase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="DNA TOPOISOMERASE, TYPE IA, CORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="183"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="809" mass="89256" checksum="1FF2E9BAAA5C283D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXD4</accession>
    <name>A0A3S7WXD4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta propeller protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_230005300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXD4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0060"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002054">
        <property type="entry name" value="Putative beta propeller protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002061">
        <property type="entry name" value="Putative beta propeller protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="344"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="477" mass="53724" checksum="B282E8E161348BBC" modified="2019-05-08" version="1">MNADWTLPLRKVPVHATKDPSVAWNTVHLCYEQTFFGQITSLRYNHAGSLLGGTSTNQFALLRVPQTDGVVVNEQTERKNYSVRFREDDKLYIQAVDQRVILRSSETAFERQYLGHSRDVRSAIFIGRHNFASASDDTTVKLWDLMSDDDLGTARIHADYVRCLEPYAGGSFFSGSYDHRVNLWDPRTGMAAPLQTSGDVITQAVEALCFVPSEEIVAVGAGDRVVVFDPRKGLSTPLFQGSFHTKSVVAVAYSQKLRSLLTGSLDCRVKMFSLDGSELRCIANKRFENGVTSLAVHPGSMEYAVGSTTGELNVYRFRKADMDKEDASEELVLDKKTRSKEQVLQDKMKEVQFELGSYQYGKALKTALYSRHPDVLVSTFEELVRRGAVHVALNNQNDRTIVRVLRFATHYVEKPQFTDTMLVVFETVFDIYSAYVGKSAFFHREILNAQKKIGASLAVMQRMERSMGIMEMIVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXI2</accession>
    <name>A0A3S7WXI2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230007600</name>
        <name evidence="3" type="ORF">LdCL_230008100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXI2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0370"/>
    <dbReference type="OrthoDB" id="264675at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="185" mass="21585" checksum="57ED3D0454EF6E06" modified="2019-05-08" version="1">MAGQIRNSWRRRIYLWLITSTRDRRNRTDDVGTHLQAARRERNKVHRVNDLLHASGMWHHPHDTLEGIILQGMGKGLAWSFVIVPACFVLTFIVCITSYRGGDWRAQQQHAQEEWQHHLLEAAQKRAIADKELQSVCNYAMEAKSLLRPIPEERRWGAQLEANMAFINEKLQRHLGDDESTRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXX7</accession>
    <name>A0A3S7WXX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230019100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXX7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1570"/>
    <dbReference type="OrthoDB" id="273669at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1110" mass="113691" checksum="CC83EAEFB90B6574" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY82</accession>
    <accession>E9BGQ3</accession>
    <name>A0A3S7WY82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_15880</name>
        <name evidence="3" type="ORF">LDBPK_240410</name>
        <name evidence="2" type="ORF">LdCL_240009000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861131.1">
        <property type="nucleotide sequence ID" value="XM_003861083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY82"/>
    <dbReference type="GeneID" id="13390581"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0520"/>
    <dbReference type="OMA" id="VGMERPY"/>
    <dbReference type="OrthoDB" id="272514at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="756" mass="79659" checksum="162E75246A84CDC3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZD0</accession>
    <name>A0A3S7WZD0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250026400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2530"/>
    <dbReference type="OrthoDB" id="273148at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1481" mass="156652" checksum="BD0AB541A865AD4D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X037</accession>
    <name>A0A3S7X037_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar attachment zone protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_260027200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2840"/>
    <dbReference type="OrthoDB" id="267403at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="2135"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2074"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2235"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1623"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1813"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1977"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2241"/>
            <end position="2256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2256" mass="231544" checksum="B4DEFE63B61ACCCB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0H9</accession>
    <name>A0A3S7X0H9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA/TS-N domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_270012200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0H9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0940"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="363"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="411" mass="44484" checksum="B336771E08C6E22A" modified="2019-05-08" version="1">MEYQIISSKGDKFALCIDDDMTVGDVKGVAAAMLDAPDDVVMTVSLNGKLLKDDAETWGELRRRLFRSHQPHPMQRKLFCNVTDRPVVESQSAEMLRMLPSKEEKKLEQEKEREKVAAMDSMVDTLADNPAFLEGMLSMNPMIKRMQKKSPEVARMLKDPDTLRMLLKSSVDPQRRREMERNAELQLAHIAALPGGQQMINHYMDQLTEDEEETDAQRQLRIGRSTAEVSDEIAHPDPTKEANNDPLPNPWATPAATASGAASQTGGAFPFGDAEGFPFFSPFGFPPAAASSPNGAATDPVASSFVGGSAAASSSGPDQEVMNSMIQMMMQSMMTPPSAPTTATTDAQSPSTAAAPVPASPSVLSEETVQRGLSALREMGFEDEALCREALTACGGDAEAAVDYIAEHQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0V3</accession>
    <accession>E9BJA3</accession>
    <name>A0A3S7X0V3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_30550</name>
        <name evidence="8" type="ORF">LDBPK_271730</name>
        <name evidence="7" type="ORF">LdCL_270024500</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862024.1">
        <property type="nucleotide sequence ID" value="XM_003861976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0V3"/>
    <dbReference type="GeneID" id="13386759"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2670"/>
    <dbReference type="OMA" id="ARQWTIR"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000004">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="12"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP47468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="372" mass="41528" checksum="816F1183AB44055F" modified="2019-05-08" version="1">MLRLSVALWRRRAAGIVGLPNVGKSTLFNALTCSQIAKTGNFPFCTIDANTSKVPIVDPRLRQLAQFTQAEKIVDVEVDLTDVAGLIAGASKGAGLGNKFLADIRNCAVLLHTVRCFESSKEGFDTPHPLDDIHVILSELVLSDLEMVEKRMRKVQKTMKAQDVEYSFLKRLQQWLEEGKPAADMPAKAKLTVAEKGLLQSYDLLSHKPMMFVLNVDERGVKDGNAFSREVEAAFGAERTCRVSVAIEEQTAQLASREEQLMFLEEYGIDVPRGQVLMKQVYALLKLQSFFTVGPKMAHGWTVAQGSTARQAAGEIHSDFEKNFVRAKVMTWDTFIGRPNLESAEMQMRTVNDRYVMQDGEVFIVEHNTQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1I1</accession>
    <accession>E9BJP2</accession>
    <name>A0A3S7X1I1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonopyruvate decarboxylase-like protein</fullName>
            <ecNumber evidence="6">4.1.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Thiamine pyrophosphate enzyme, N-terminal TPP binding domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_22305</name>
        <name evidence="7" type="ORF">LDBPK_281710</name>
        <name evidence="6" type="ORF">LdCL_280022000</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862270.1">
        <property type="nucleotide sequence ID" value="XM_003862222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1I1"/>
    <dbReference type="GeneID" id="13387006"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2240"/>
    <dbReference type="OMA" id="RQCDGPA"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000126">
        <property type="entry name" value="Phosphonopyruvate decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000127">
        <property type="entry name" value="Phosphonopyruvate decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051818">
        <property type="entry name" value="TPP_dependent_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42818:SF1">
        <property type="entry name" value="SULFOPYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42818">
        <property type="entry name" value="SULFOPYRUVATE DECARBOXYLASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="4">
        <location>
            <begin position="259"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="415" mass="44580" checksum="B2255D4149D6FB49" modified="2019-05-08" version="1">MLRCCRRALEGNKQLSPEYLVRSLKEHGTSAFFGMPDYYLCPLTSYLADNTAAGEYVMATNCGNAVAMAAGYYLSTLRVPCVFMQNSGIGDSMNPLLTLFNQDAYRMPCLMLISWRGKLDTADEQAKPGLVAQGRLTEHCLAAVGIPYAIMGNSLDVAMNWDVTMDKAYHHLDSEKTPFAVLLEPGTIAPYMQRRPEADALPTAPLDHDAVANQVCRQFNATDAFVCSCGSVQESLRRARAMVSGDTAVQDLLLADSPGHATGVATGIALSRPSLQVVCIEGDGAALVHLNAMATNGGLKAMKDVTTGAGLLQNFKHIVVNDGCYSMEGGQMTAAFDASLTGVAKACGYFAVREEPVIELGDLVAALAELRQCDGPAFVEVVVSKTRTSPADGKVRRNLQAEKLRFSEFLNRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1M4</accession>
    <accession>E9BJS5</accession>
    <name>A0A3S7X1M4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Double-stranded DNA-binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Double-stranded DNA-binding domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Double-stranded_DNA-binding_domain_containing_pro tein_putative/Pfam:PF01984</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_13130</name>
        <name evidence="8" type="ORF">CGC21_22460</name>
        <name evidence="6" type="ORF">LDBPK_282040</name>
        <name evidence="4" type="ORF">LdCL_280025500</name>
        <name evidence="5" type="ORF">LDHU3_28.2690</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862303.1">
        <property type="nucleotide sequence ID" value="XM_003862255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1M4"/>
    <dbReference type="SMR" id="A0A3S7X1M4"/>
    <dbReference type="GeneID" id="13387039"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2690"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.140:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5431587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="113" mass="12995" checksum="FF80B57FF32EC875" modified="2019-05-08" version="1">MSRVPISEEQAQQMVAKQQAQQERMEAFEEQKENMLRAFVSAEGRERLKRIAQVKAGRAQAVEMHIIQAVQRGKMQPPVSDDTVRELLGQMANQEAESRSQITIARKRTDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X226</accession>
    <name>A0A3S7X226_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280037800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X226"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280037800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.4300"/>
    <dbReference type="OrthoDB" id="261398at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="234" mass="26216" checksum="50A0298A103E00B6" modified="2019-05-08" version="1">MGYGVRLSILPLLGGCRRWFSGCGTGSILGTATMAGSLLKTLQEDLRDETELRTKGIGETLQNYVHRAELSHMESPEADEAFSKSLDAKVDDLFARIPLPQDPMKVALALTDEEAKEEAAAELVKEAVREMYWRKLDAKQAEELRLKRAQEKLQTQGAIQYFEERREERLREHTNRRFAAQPLAVEPQSPAGKGVTASPLQNPDSTLSAEELCEELATLKANVSRLEELLRYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X262</accession>
    <accession>E9BKK1</accession>
    <name>A0A3S7X262_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exonuclease, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Exonuclease_putative/Pfam:PF00929</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_290550</name>
        <name evidence="6" type="ORF">LdCL_290010300</name>
        <name evidence="7" type="ORF">LDHU3_29.0780</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862472.1">
        <property type="nucleotide sequence ID" value="XM_003862424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X262"/>
    <dbReference type="GeneID" id="13387211"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0780"/>
    <dbReference type="OMA" id="PPVCYRY"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF65">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="222"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="502" mass="54749" checksum="E7CE226B7F8895DA" modified="2019-05-08" version="1">MGRIRSLAKELRQLELQKQTASPPPPRAASGDDVLDDATRSATSSRKPEAPSCSSSPRVGDILTNAAHAATTAEAEAVPSSSPASSTGAAAEPQPTSAFPLPRLSSSSRDGAHDRSRNSLYSLGGSRFDILMGGSHGDGGACRKSQVRKATKACASGGGKNGAATTTATQEPQLRGDAEGSSLLENGEDGEAATNPAPPLGTSSGIPTRPPFKRLLAQPFSHVLVCDFEATCASGSVHYPHEIIEFPVVVLDTATLRIVAEFHRYVRPLRNPKLTAFCTELTGITQEMVDVADPLPTVVAQFQDWLKTEVYPLCRMWARHYGPNRLSHNLKSEQRRFVYDEHTDAAKANTSAEAMICMATDGPWDMRRFMHECSVLRDGVDFPPVCYRYINVRHSYSDHFKCRQAKLTHMLKKMSMSFEGRRHSGIDDTRNIARVLAELFARGYRVHHVSTIKYAHRGDAFLESDRAAQELLSEFGETDETHTSKHATVHKGGGRQRGVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2R9</accession>
    <name>A0A3S7X2R9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290031500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2R9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3780"/>
    <dbReference type="OrthoDB" id="267326at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="764" mass="80773" checksum="FF47E0943AD4995A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3D7</accession>
    <name>A0A3S7X3D7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_300020000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3D7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300020000"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10375" checksum="06CEC81308FCA654" modified="2019-05-08" version="1">MPFPIVALDQGHASRLPMPSAHCAHQQCAKATRHPAASFAPHRVLRRPCTTPFKPLTMGGLEVAPREAYCGPAPGVAEIHCGSVEAAPMQVRSALLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5H5</accession>
    <accession>E9BNS6</accession>
    <name>A0A3S7X5H5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_20415</name>
        <name evidence="5" type="ORF">LDBPK_321730</name>
        <name evidence="4" type="ORF">LdCL_320022800</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863589.1">
        <property type="nucleotide sequence ID" value="XM_003863541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5H5"/>
    <dbReference type="GeneID" id="13390639"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2190"/>
    <dbReference type="OMA" id="YSGHIEY"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="98831" checksum="91FDF2CB3737A7F5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5R7</accession>
    <name>A0A3S7X5R7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320031200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5R7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3200"/>
    <dbReference type="OrthoDB" id="244874at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1016" mass="108596" checksum="180DA612230832EF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6Q6</accession>
    <name>A0A3S7X6Q6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330018500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1880"/>
    <dbReference type="OrthoDB" id="273467at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1381" mass="150456" checksum="23211C0088A23E73" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8Z5</accession>
    <accession>E9BRZ7</accession>
    <name>A0A3S7X8Z5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_6135</name>
        <name evidence="12" type="ORF">LDBPK_351210</name>
        <name evidence="11" type="ORF">LdCL_350016900</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864706.1">
        <property type="nucleotide sequence ID" value="XM_003864658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8Z5"/>
    <dbReference type="GeneID" id="13387586"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1610"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001682">
        <property type="entry name" value="Putative pre-mRNA splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF261">
        <property type="entry name" value="SPLICING FACTOR ATP-DEPENDENT RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="226"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ38026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP44394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="704" mass="79815" checksum="0B9E49DD415B00E2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB63</accession>
    <name>A0A3S7XB63_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase, putative</fullName>
            <ecNumber evidence="10">3.6.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="11">ATP-dependent_RNA_helicase_putative/GeneDB:LmjF.3 6.3000</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Putative ATP-dependent RNA helicase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_28400</name>
        <name evidence="10" type="ORF">LdCL_360038000</name>
        <name evidence="11" type="ORF">LDHU3_36.4350</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XB63"/>
    <dbReference type="SMR" id="A0A3S7XB63"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4350"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002225">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000005">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="311"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5434888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="954" mass="106670" checksum="88DEFA9DAED8E59D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBD5</accession>
    <accession>E9BU88</accession>
    <name>A0A3S7XBD5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_14185</name>
        <name evidence="2" type="ORF">LDBPK_363800</name>
        <name evidence="1" type="ORF">LdCL_360045000</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865494.1">
        <property type="nucleotide sequence ID" value="XM_003865446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBD5"/>
    <dbReference type="GeneID" id="13388380"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360045000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5130"/>
    <dbReference type="OMA" id="CTKEMVL"/>
    <dbReference type="OrthoDB" id="270164at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="121" mass="13339" checksum="75CC87EA96564F72" modified="2019-05-08" version="1">MALVISDEATREAERILACSNSFEVLELSPSNCTKEMVLEQYEAKVSLFKGLFRNKLAMQAKAKLGNAKVRLADAQLREKEAAALKGLQSDAHKNYAELQALEVRTRVLEMRAATVQGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBP3</accession>
    <accession>E9BUL3</accession>
    <name>A0A3S7XBP3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">WD_domain_G-beta_repeat_putative/Pfam:PF00400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_365050</name>
        <name evidence="7" type="ORF">LdCL_360057700</name>
        <name evidence="8" type="ORF">LDHU3_36.6770</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865619.1">
        <property type="nucleotide sequence ID" value="XM_003865571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBP3"/>
    <dbReference type="GeneID" id="13388505"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360057700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6770"/>
    <dbReference type="OMA" id="HSVKCWD"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000347">
        <property type="entry name" value="Pre-mRNA-splicing factor PRP46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5435084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="509" mass="55029" checksum="BCDEA9E7EB211E4B" modified="2019-05-08" version="1">MNQTSMEELLAANADAAQELRGVAVLDVPAFDPDGPPRTFISNRSSSSAMMSEAMRRRANVLWRALYPRTAPPTTAAVATSSKNGVGADAATQTDPPCHDVVRQGIVTVVSNTSGEATSKPSASASSGMLTHKRARDGDDIVSVNPEQLKARSALVVSKAAAEEAEARKYSPPPKWRLAKVLVGHQGWVWATAVEPGNKWFATGSFDAIIKVWDLETGVLKMNLTGHKEAVRSISLSKVSPYMFSGSDDHSVKCWDLERNEVVREFFGHKSAVHCVAAHPSLDVVISGGRDKTVRVFDLRSRAVVHTMLGHTDSVMSLVVQQEEPQVISGGSDGFIYLWDLASGKPLQRLTRHKKPVRGLAFTAAGDALVSCGADEVRVWKLPSGHFVTNASTRVLDGHKSRPATSASAGGADEVGEYSYRWSCCAVSPRNVLAVGSQDGELAFYDWNIPQPRRVAGRHYAPYQWAKTKSLPGTLHGEGGINALTYDVSGTRLITAESDKSVKIWRMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9B771</accession>
    <accession>A0A451EJ64</accession>
    <name>E9B771_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_010060</name>
        <name evidence="2" type="ORF">LdCL_010005600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857820.1">
        <property type="nucleotide sequence ID" value="XM_003857772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B771"/>
    <dbReference type="GeneID" id="13390031"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0080"/>
    <dbReference type="OMA" id="KERANIN"/>
    <dbReference type="OrthoDB" id="277830at2759"/>
    <dbReference type="PhylomeDB" id="E9B771"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23710">
        <property type="entry name" value="mL85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="249" mass="27322" checksum="8714BDFE0792F1D9" modified="2011-04-05" version="1">MRRLPLLCRRTSGCCGATASGSGSSSAAALAAVAAPSVLMLAARGIATNGRVTNEDRRWWLVHLECAPDVTPGTFVSWLDCCGTHTTKKLIERNIWTIEQVAELDSDRVDELKYKEGCLKMDVVWEHARTIITPLKQREVSGGVESQLQSRILELRKKRELERQRESLVKERATVSDKREETLRKLRESIAAKKAALRKKLDEKHGEAAPAAAESASTEAHRGTAEAAVEDEAVGNIVDRMSGGKPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7W9</accession>
    <accession>A0A3S5H572</accession>
    <name>E9B7W9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_040031</name>
        <name evidence="2" type="ORF">LdCL_040005400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858066.1">
        <property type="nucleotide sequence ID" value="XM_003858018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7W9"/>
    <dbReference type="SMR" id="E9B7W9"/>
    <dbReference type="GeneID" id="13390677"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040031"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040031.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0050"/>
    <dbReference type="OMA" id="QADMIVH"/>
    <dbReference type="OrthoDB" id="258193at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7959" checksum="CFB8DB25BE7689D8" modified="2011-04-05" version="1">MSPRVAGFLIGGFVTAMASAILLQYDVLRKQELTTRKTEEVAVQADMIVHRFHVVEAGLRTLSEGGEARPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9A0</accession>
    <accession>A0A3S7WPZ8</accession>
    <name>E9B9A0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome activator complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_071090</name>
        <name evidence="3" type="ORF">LdCL_070015700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858545.1">
        <property type="nucleotide sequence ID" value="XM_003858497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13391829"/>
    <dbReference type="KEGG" id="ldo:LDBPK_071090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_071090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1300"/>
    <dbReference type="OMA" id="WATHWPL"/>
    <dbReference type="OrthoDB" id="242645at2759"/>
    <dbReference type="PhylomeDB" id="E9B9A0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="2361"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1828"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2334"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2448" mass="261488" checksum="BD3AF973102AF16F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BA05</accession>
    <accession>A0A3S5H6E4</accession>
    <name>E9BA05_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_091200</name>
        <name evidence="2" type="ORF">LdCL_090018400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858798.1">
        <property type="nucleotide sequence ID" value="XM_003858750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BA05"/>
    <dbReference type="GeneID" id="13392132"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1430"/>
    <dbReference type="OMA" id="YSIDAWG"/>
    <dbReference type="OrthoDB" id="271080at2759"/>
    <dbReference type="PhylomeDB" id="E9BA05"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033558">
        <property type="entry name" value="IFT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24850" checksum="BC316F9130D3C4BF" modified="2011-04-05" version="1">MLTTCSGSPIHASPFPLPILPHPKRREPHRVTTQRTQTRRDLPEVQHAQTERKAKMAATNSRVFFDVHFISFHDDNLPGTAITDSKAPTSFVLTTGGFPQEVIVQTRAASAKISKLSVALNDAKDILVEKCCGETPTAFEVMAERTLARGSVGGSSSNPSAAAAAADGGVGGPQTETFDLDPEGAGRDIRFIRLTILSGYSEFVAVYSIDAWGEESQQRVAVLQSKPEVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAV5</accession>
    <accession>A0A3S7WRQ0</accession>
    <name>E9BAV5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60Kd inner membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_111170</name>
        <name evidence="8" type="ORF">LdCL_110017600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859092.1">
        <property type="nucleotide sequence ID" value="XM_003859044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAV5"/>
    <dbReference type="GeneID" id="13389865"/>
    <dbReference type="KEGG" id="ldo:LDBPK_111170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1400"/>
    <dbReference type="OMA" id="RDFFRFP"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="PhylomeDB" id="E9BAV5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF13">
        <property type="entry name" value="60KD INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="7">
        <location>
            <begin position="158"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="441" mass="49935" checksum="240242474507B9A8" modified="2011-04-05" version="1">MLLGSRLAGAPAGVSATALLHSCAPATPACRLLSIRRNGAPTFSSIACGHGVRGGRCSSGMVVALHVQQRRISWNPLKWGRTDVGRSTNPQLEEELPEIFAAQPIEVDDYICPDKSLFERLEDFWDWAVSFLQPVEKQVEIMRSLRHDGFMSFDLGGWGHVFFFYGLCMRVLTLIPSLYSHRNSLRMAHIGPQISEITNNQNKAKNDRTLSSAEKRVIKDGYNRMKYALCKKHNCSQWKSFLTTFTTPITMSAFLSIRRLAMYETDLEMAPFLWVKDLTMPDPTYALPAICAGMFLLNFEMNQRMQRGGRSASGLYVRWVVRASSVVGIYFFAGQPSAMFAYWIGLSTAGLLQPILLRWQPFRDFFQFPDPPQAAKSNIISEIKGPSLYERLFATQEEKTRLEAQRKADRIKNSAARIETVDDYEVVFDDDVKEKPSGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE46</accession>
    <accession>A0A3S7WVC3</accession>
    <name>E9BE46_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_190510</name>
        <name evidence="3" type="ORF">LdCL_190010100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860229.1">
        <property type="nucleotide sequence ID" value="XM_003860181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13386041"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0570"/>
    <dbReference type="OMA" id="CYDQILL"/>
    <dbReference type="OrthoDB" id="267603at2759"/>
    <dbReference type="PhylomeDB" id="E9BE46"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1509"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="714"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1509"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1605" mass="167789" checksum="5B974ED21281883C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BID8</accession>
    <accession>A0A3S7WZV6</accession>
    <name>E9BID8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_261260</name>
        <name evidence="2" type="ORF">LdCL_260018200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861713.1">
        <property type="nucleotide sequence ID" value="XM_003861665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BID8"/>
    <dbReference type="GeneID" id="13388959"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1560"/>
    <dbReference type="OMA" id="AYLLCVH"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="PhylomeDB" id="E9BID8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1096" mass="113898" checksum="4807CCDA894AA169" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIW9</accession>
    <accession>A0A3Q8ID52</accession>
    <name>E9BIW9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MP44, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_270350</name>
        <name evidence="1" type="ORF">LdCL_270008300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861892.1">
        <property type="nucleotide sequence ID" value="XM_003861844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIW9"/>
    <dbReference type="GeneID" id="13389153"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0420"/>
    <dbReference type="OMA" id="WFTARTK"/>
    <dbReference type="OrthoDB" id="278615at2759"/>
    <dbReference type="PhylomeDB" id="E9BIW9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23725">
        <property type="entry name" value="RNaseIII_KREPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="373" mass="42339" checksum="446EC752272C88B1" modified="2011-04-05" version="1">MAPPQTTLSLDANLRNTLRSLLIERLCSPTQPLPAKQLYDELTNRSRLVEEFHFSKTSRRITRQRLALQFLRRYNVLLHGLLFYSEGTRTWNTTTEFHRLAILGESVLLTEVRTRLLKLFPAMPYAAYVQSLPHMVGEEALAAAFDRYEMQNIVGAKPSNRRSGTPLTRMQKSHMLCAIVAEMYWFTARTKPTDLTHNNALFPPSDVLILHVLSTHLLENLPAELIYNVVEPIVADIKRVWVNEPMSLPSQLRLTPRTVCALSLNAVPVEPQYTAKEDAVMSLQKKHAEAHRRQHALTCEPDHSCVKSFMRPLCNYRIFEGPRYQILSSDNRVAPLPLAQERSSLPASAVCTVVGDAESAARAMELAKMAEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJS6</accession>
    <accession>A0A3S7X1N7</accession>
    <name>E9BJS6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter 3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Zinc transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_282050</name>
        <name evidence="7" type="ORF">LdCL_280025600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862304.1">
        <property type="nucleotide sequence ID" value="XM_003862256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJS6"/>
    <dbReference type="GeneID" id="13387040"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280025600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2710"/>
    <dbReference type="OMA" id="VGFMNAV"/>
    <dbReference type="OrthoDB" id="265977at2759"/>
    <dbReference type="PhylomeDB" id="E9BJS6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="464" mass="48469" checksum="E29FB7327B736357" modified="2011-04-05" version="1">MAQPTLAMLRQLVGDLVRAAVAVKAREPLEFQSAFASATKTMAYSPGCADIHSDTNGDGTRHRLSYAESGHDHGHSHGSGSDGGHGHSHGSGSDGGHGHGHSHGCASVEGDYMLGLHIAAIFIILAASVVGTLIPIVGKRVPALRLHAYVYAVGKAAATGVVLAVAMIHMINHASVVFGADCVPESFREMYEGWAFLFAMIAAIVMHAIDGTVGWIAERWTARAAGKVPPTDPCHGLLRNECFAVRKDGLAERPDEDVLKDMYGGAEDGQGGVSVPQMDAAKCVGHQHGVAVPEDMPPLQRVVAALCMELGVTLHSVFVGLALAVSNGADLRALIIALVFHQLFEGLAMGARLADASFKISLELALMLVFSLSAPIGIAAGTGTVMASRDALSGTTYALVSAILDSICGGIMLYIAFNLLFVDFSHDLHVHCGAKSKCGVAKRIGMYAGLWIGAAVMAIIGKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJZ2</accession>
    <accession>A0A3Q8IGY7</accession>
    <name>E9BJZ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_282720</name>
        <name evidence="17" type="ORF">LdCL_280032300</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862370.1">
        <property type="nucleotide sequence ID" value="XM_003862322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJZ2"/>
    <dbReference type="GeneID" id="13387106"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3690"/>
    <dbReference type="OMA" id="QLGGCTF"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="PhylomeDB" id="E9BJZ2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001824">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="16">
        <location>
            <begin position="283"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="937" mass="102174" checksum="BC3B891CF2BC696E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR16</accession>
    <accession>A0A3Q8IUN5</accession>
    <name>E9BR16_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class IV, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_342180</name>
        <name evidence="2" type="ORF">LdCL_340029500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864377.1">
        <property type="nucleotide sequence ID" value="XM_003864329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR16"/>
    <dbReference type="GeneID" id="13392786"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3640"/>
    <dbReference type="OMA" id="PTIMPVQ"/>
    <dbReference type="OrthoDB" id="277045at2759"/>
    <dbReference type="PhylomeDB" id="E9BR16"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000019">
        <property type="entry name" value="Aminotransferase class IV, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="385" mass="42130" checksum="01D805C81540EF95" modified="2011-04-05" version="1">MKCAYLSLLAGVSSLDKWTDTSLQRTRTKNTMERIPFVVRRMVATEQNCAFVHFFASFADVSAAPLAIETKAFRSAAAGGAADDAEPAYQLVYDVMRSRNGHILFKKSYAERFTHSLTLAAPALALPAELQSLVQARLQAYIESPGVYLDGVTEKNVKLLSWIPATGASTKQAEAFPIPVIIMLAKSSYPSESMYREGAKLGLLFNAHRINPNAKVAQMGLRDRAHAYLTENGVYEVLLVHDAADAYLVPEGSRSNYLLQKSDGTWWCSAEEDILVGITLKTTYRVLQACGLGSVQHAKLTLKDILESKLLFILGTSPTIMPVQSVLLYGDSETRRFYEEAVRALGATAGTVQQVSDVKAELLFPVNVELASALRTQYFAEAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRA3</accession>
    <accession>A0A3S7X894</accession>
    <name>E9BRA3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_343050</name>
        <name evidence="2" type="ORF">LdCL_340039400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864464.1">
        <property type="nucleotide sequence ID" value="XM_003864416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRA3"/>
    <dbReference type="GeneID" id="13392873"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340039400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5190"/>
    <dbReference type="OMA" id="KNPMHLY"/>
    <dbReference type="OrthoDB" id="276277at2759"/>
    <dbReference type="PhylomeDB" id="E9BRA3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF1">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20479" checksum="C4B17E0B93EED64D" modified="2011-04-05" version="1">MNGIACAASVRVTSAGPSVSGPLDHSTLAALRTPARHKASTIRIANRKKVEMFVGKRYHLPTRLRVAAPDIAAEWDHEKNPMHLYPDIVSIGYMHPVYWKCRGCATSYQMSVEKRVVRGGRCPVCEDRELSRSMAFNTAAMDVGSAHAREAGIECGSAMQPLLPGEENRSLRPKRTTMLNLRTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSV5</accession>
    <accession>A0A3S7X9W8</accession>
    <name>E9BSV5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_354350</name>
        <name evidence="10" type="ORF">LdCL_350048600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865013.1">
        <property type="nucleotide sequence ID" value="XM_003864965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSV5"/>
    <dbReference type="GeneID" id="13387891"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350048600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5760"/>
    <dbReference type="OMA" id="HHIIANQ"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="PhylomeDB" id="E9BSV5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.210.20:FF:000002">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053997">
        <property type="entry name" value="SAS-6_C_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22218">
        <property type="entry name" value="SAS-6_C_CC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="144"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SAS-6 C-terminal coiled coil" evidence="9">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="357"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="487"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="89681" checksum="14C73811C18C5703" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUK2</accession>
    <accession>A0A3S7XBM3</accession>
    <name>E9BUK2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_364940</name>
        <name evidence="7" type="ORF">LdCL_360056500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865608.1">
        <property type="nucleotide sequence ID" value="XM_003865560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUK2"/>
    <dbReference type="GeneID" id="13388494"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360056500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6650"/>
    <dbReference type="OMA" id="VRRNLCQ"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="PhylomeDB" id="E9BUK2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002613">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="727" mass="80263" checksum="3FC97F64D6930E14" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q9BIE1</accession>
    <accession>E9BED5</accession>
    <name>Q9BIE1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cysteine peptidase A (CBA)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Cysteine peptidase A (CPA)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Cysteine proteinase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Cysteine_peptidase_A_(CPA)/GeneDB:LmjF.19.1420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_191460</name>
        <name evidence="13" type="ORF">LdCL_190020300</name>
        <name evidence="14" type="ORF">LDHU3_19.1770</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2001" name="Nucleic Acids Res." volume="29" first="3231" last="3240">
            <title>Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania.</title>
            <authorList>
                <person name="Dubessay P."/>
                <person name="Ravel C."/>
                <person name="Bastien P."/>
                <person name="Lignon M.F."/>
                <person name="Ullman B."/>
                <person name="Pages M."/>
                <person name="Blaineau C."/>
            </authorList>
            <dbReference type="PubMed" id="11470881"/>
            <dbReference type="DOI" id="10.1093/nar/29.15.3231"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1S</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY028171">
        <property type="protein sequence ID" value="AAK27384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860318.1">
        <property type="nucleotide sequence ID" value="XM_003860270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9BIE1"/>
    <dbReference type="SMR" id="Q9BIE1"/>
    <dbReference type="MEROPS" id="C01.076"/>
    <dbReference type="GeneID" id="13386130"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1770"/>
    <dbReference type="OMA" id="AKPPYWI"/>
    <dbReference type="OrthoDB" id="251836at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000138">
        <property type="entry name" value="Cruzipain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2250:FF:000009">
        <property type="entry name" value="Cysteine peptidase A (CPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044738175" evidence="9">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="129"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAK27384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5429538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="354" mass="38903" checksum="C849061616AF0FDA" modified="2001-06-01" version="1">MARRNPFFFAIVVTILFVVCYGSALIAQTPLGVDDFIASAHYGRFKKRHGKPFGEDAEEGRRFNAFKQNMQTAYFLNAHNPHAHYDVSGKFADLTPQEFAKLYLNPNYYARHGKDYKEHVHVDDSVRSGVMSVDWREKGVVTPVKNQGMCGSCWAFATTGNIEGQWALKNHSLVSLSEQVLVSCDNIDDGCNGGLMEQAMQWIINDHNGTVPTEDSYPYTSAGGTRPPCHDNGTVGAKIAGYMSLPHDEEEIAAYVGKNGPVAVAVDATTWQLYFGGVVTLCFGLSLNHGVLVVGFNRQAKPPYWIVKNSWGSSWGEKGYIRLAMGSNQCLLKNYAVTATIDDSNTSHVPTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I910</accession>
    <accession>E9BAN4</accession>
    <name>A0A3Q8I910_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_110460</name>
        <name evidence="2" type="ORF">LdCL_110009500</name>
        <name evidence="3" type="ORF">LDHU3_11.0560</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859023.1">
        <property type="nucleotide sequence ID" value="XM_003858975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I910"/>
    <dbReference type="GeneID" id="13389830"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0560"/>
    <dbReference type="OMA" id="CVMAVIE"/>
    <dbReference type="OrthoDB" id="263975at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="643" mass="68888" checksum="59ACFE4E10D6B1E6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9F7</accession>
    <accession>E9BCV0</accession>
    <name>A0A3Q8I9F7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain/ubiE/COQ5 methyltransferase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_24890</name>
        <name evidence="3" type="ORF">LDBPK_160970</name>
        <name evidence="2" type="ORF">LdCL_160014900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859783.1">
        <property type="nucleotide sequence ID" value="XM_003859735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9F7"/>
    <dbReference type="GeneID" id="13393131"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1160"/>
    <dbReference type="OMA" id="SMEEWDR"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF80">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="488" mass="55416" checksum="1D9701C6965D7F69" modified="2019-04-10" version="1">MRLLSKVIVGTTCVTIFCGSAYVAAITLAPPPNYTVSNNDRLKSYDKLSIDNLYEKKTKCQEFYLGLSRWRRKMLRDEGLLRGRVLEVGAGCMGNYAYYPHKYFSDDSEVQRHLRGMLGRRDDTQAAGSGDNSTSYMLQHIEKENPCDEIVLCDRSAGMVQSCIAKIQSRLGYTPYRYPDYDIAGIRNSIEARVRAQHDAQRLGPDSADKAALRKRKIVREDGTVQEVLVTPLSGTEEEEFLEATSSQTNLAADAIIVPVLQALDTGDKLPLLSKEGEATLARREREVQARGEFRRRVESKLQREERLSMLKRGRADVSAADASTTEKNQLIEVPPELRGGNRELERQPLFAVANYAAEQLPFPDNSFDTVVDMFGLCSFDDPVRALRELSRVCKPGGKLLLIEHGKGHSTRVNNHLDKWAPRHAKSWGCWWNRDIRRVIRLSGLSVEKWESKHFGTSHYIIAKPYKSMEEWDRFELQRKQQARKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9Z0</accession>
    <accession>E9BDQ6</accession>
    <name>A0A3Q8I9Z0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-finger of C2H2 type/Zinc-finger double-stranded RNA-binding, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Zinc-finger_of_C2H2_type/Zinc-finger_double-stran ded_RNA-binding_putative/Pfam:PF12874/Pfam:PF12171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_180760</name>
        <name evidence="5" type="ORF">LdCL_180012700</name>
        <name evidence="6" type="ORF">LDHU3_18.1010</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860089.1">
        <property type="nucleotide sequence ID" value="XM_003860041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9Z0"/>
    <dbReference type="GeneID" id="13385946"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1010"/>
    <dbReference type="OMA" id="HKASRQH"/>
    <dbReference type="OrthoDB" id="248409at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10835" checksum="80F885DA31FA7553" modified="2019-04-10" version="1">MSSSAGASSSPMSTDRCSFYCPVCNIQFSDSHAAEAHKASRQHKRKSGELEWEAQQYKKDADVTPDDVWALVRRKQAELHVIPWSELKYSEEESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA65</accession>
    <accession>E9BCD5</accession>
    <name>A0A3Q8IA65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC-2 type transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette protein subfamily G, member 4, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">ATP-binding_cassette_protein_subfamily_G_member_4 _putative/GeneDB:LmjF.15.0890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_30315</name>
        <name evidence="14" type="ORF">CGC21_1500</name>
        <name evidence="13" type="ORF">LDBPK_150950</name>
        <name evidence="11" type="ORF">LdCL_150015000</name>
        <name evidence="12" type="ORF">LDHU3_15.1230</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000037">
        <property type="protein sequence ID" value="TPP53167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859619.1">
        <property type="nucleotide sequence ID" value="XM_003859571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA65"/>
    <dbReference type="GeneID" id="13392959"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1230"/>
    <dbReference type="OMA" id="WLAWEDY"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001495">
        <property type="entry name" value="ATP-binding cassette protein subfamily G, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF127">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="60"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5428792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP47718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP53167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="741" mass="83044" checksum="2C75CDAF2822D445" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAD7</accession>
    <name>A0A3Q8IAD7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_160012600</name>
        <name evidence="12" type="ORF">LDHU3_16.0890</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAD7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0890"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5428936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="740" mass="78429" checksum="99337E2DC8A8FB0B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAE8</accession>
    <name>A0A3Q8IAE8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5, putative</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_160013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAE8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1020"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000112">
        <property type="entry name" value="Mov34/MPN/PAD-1 metallopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="70"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="491" mass="53711" checksum="F27574441C004FF2" modified="2019-04-10" version="1">MSTSAASPAQRSPGQSQWSLSTPVSSRPQHKLRSSVPIVSDAYWTPDFAHMETARRQKPWRFDSLFFESVSVSLAATVKMFLHGTRGCPDMSQGRFNWFEVMGLLIGHFSHRELILTDSFSLPVAASEVECSMTEASQIYMANYLEYHRRLGKAEPGCLGWYHTHPGYSCFLSGIDVTTQRDSQQMQDPWVALVIDPVKTLRTGQFSMKAFRTYPEGDFQGQRPRSASHSAVDGAQPAASPASATASTMSDDYGLPPSNRVKEFGMHAHRYYELPVRIVQSARDAPLWELLQRHFWPLSLSLTFPFAPSTRICNCCSAELAKVVSALGARAQDSCTCERSPLACDSFSRRGSVGSMPLLYQSSKVVGSAQACSGGDGSADADDAAEMEQRLLAITGEVLRVRAESFSLIGASHPVHAELLAAMRAVAAAAGPATTDKRHGCTSLGTARNARNEASFSSLFTSRRDDPMEEEEEARKGGVCCRDGAFHARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAF8</accession>
    <name>A0A3Q8IAF8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_160015700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAF8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1290"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="4">
        <location>
            <begin position="548"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="962" mass="104726" checksum="44B8729272DF755A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBN5</accession>
    <name>A0A3Q8IBN5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetoplast ribosomal PPR-repeat containing protein 3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Kinetoplast_ribosomal_PPR-repeat_containing_prote in_3_putative/GeneDB:LmjF.20.0480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200010200</name>
        <name evidence="3" type="ORF">LDHU3_20.0650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBN5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0650"/>
    <dbReference type="OrthoDB" id="42736at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="552" mass="61606" checksum="1AF0C7E137F67450" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBT1</accession>
    <name>A0A3Q8IBT1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_210005800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBT1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0100"/>
    <dbReference type="OrthoDB" id="276706at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="493" mass="51951" checksum="C4163E87D716B859" modified="2019-04-10" version="1">MSVTTELAGLVRRLPPRAYERVLLLLHCLATSSEGSQGGSNPQTLSLQVICDVVLCACPGPVPRFLFALSCNDKLLRSADCGLTWRLCFARSSEPLKADTAGVQDLLDDVTSLLKSTEATDDVAGGEEASSVVCCADGYGDVVALCGRNGFLAVSGDKGVTFTTATNYLMGDFGEKAHLRHICVLDTDRILVSDDLRVVCVAVECTGCGPLALGKTHVALVCSTQICMLRACSFGGGARGAVVAENRKLHLSFDGSASFMEVRHSLGRIRGFNTASALRHCELPDFPHATLASSMGLQSTEASPSPPRSASVYDYVSGCKCDAAVGKGDSTAAVTQFEAGALRHGADVFYRFFFVAGCGTEVLPYDYTALLCVCTRQEGNHVVVMSTASYVSYIPFSQSRSHDRLLCTVTRSSGDGGSYLASRGSVVGTSVSRDLDRWSTPHGAAPVGLLAVGGGDILACGRNKVVSRVEGDAEAHTILHDMRVPVLSTAFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICP9</accession>
    <name>A0A3Q8ICP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310032500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICP9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310032500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4430"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="513" mass="55523" checksum="F9774FE4A9789E91" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICS4</accession>
    <name>A0A3Q8ICS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_170010600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICS4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0800"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000163">
        <property type="entry name" value="Chaperone protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="178"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="358" mass="39716" checksum="7E5A9862D6C09B02" modified="2019-04-10" version="1">MHARTHAHALQRPPPPSLCACAFFFLLGVSTVSTPLMLLRATAASTLASALLHRRGRAPRPVTAGVTASLASRCCCSPPSAALSSSYQPTSSLVLLRAATLCAPTTGSSSAWATARRWQSSGGPGYGTVPADIDSPRGAAKPTEEELHREQRRRTHGPAATAEDANKEAVSTHVSGYNPWEVLGLKPGASTQTIRLRYHELMKQVHPDMAADGTGDIPRLNQINKAYELITKSPTLDRRYRNLVSDTQYFYYKFLPEWMARNVDEMPRYWSWVKWRTPSGFHIFLLLCGFYVLGRFYAAFPMLTSVFFVSVALDVLLHTMLAPAALCMLFLYSIMAYRSYDMAWLTSPKGFLRRELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEU8</accession>
    <name>A0A3Q8IEU8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_280033300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEU8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280033300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3800"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="30"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="608"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="15">
        <location>
            <begin position="748"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="865" mass="95584" checksum="07E903176009EF09" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF67</accession>
    <name>A0A3Q8IF67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport protein Sec24A, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_290007100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF67"/>
    <dbReference type="SMR" id="A0A3Q8IF67"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0300"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="11">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="12">
        <location>
            <begin position="358"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="14">
        <location>
            <begin position="610"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="13">
        <location>
            <begin position="708"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="966" mass="106459" checksum="63FE8384CD337637" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFB7</accession>
    <name>A0A3Q8IFB7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_210028100</name>
        <name evidence="16" type="ORF">LdCL_210028200</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFB7"/>
    <dbReference type="SMR" id="A0A3Q8IFB7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1370"/>
    <dbReference type="OrthoDB" id="257378at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU78689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU78690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="443" mass="49799" checksum="C634B7B7F20EAF95" modified="2019-04-10" version="1">MREIVSCQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDESTGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRKEAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATVEEEGEYDEEQEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFI1</accession>
    <name>A0A3Q8IFI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220015300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1290"/>
    <dbReference type="OrthoDB" id="267732at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1512"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1705"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1781"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1708"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1804"/>
            <end position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1946" mass="198989" checksum="36BFE2F5F4167B41" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFW9</accession>
    <accession>E9BLW9</accession>
    <name>A0A3Q8IFW9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2H2 type zinc-finger (2 copies) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Zinc-finger protein, conserved</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Zinc-finger_protein_conserved/GeneDB:LmjF.30.2250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_6660</name>
        <name evidence="16" type="ORF">CGC21_35895</name>
        <name evidence="14" type="ORF">LDBPK_302260</name>
        <name evidence="12" type="ORF">LdCL_300028100</name>
        <name evidence="13" type="ORF">LDHU3_30.3060</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862938.1">
        <property type="nucleotide sequence ID" value="XM_003862890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFW9"/>
    <dbReference type="GeneID" id="13385646"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3060"/>
    <dbReference type="OMA" id="WTQTQQQ"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU81025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5432250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="371" mass="41989" checksum="6B79A5C3064A305F" modified="2019-04-10" version="1">MSRCGTCNVVLENGEVLRAHYGSEFHLTNVRRRVDGLRPLSQQDHRFSRNEMEGAVLGEKGTPVYSCTLCKKTFHSVQTLQTHIRSTAHLMRKEKRIIARDSETASMLTSTSLGSAAMGLHRRHNAKKSAAARGDAKPKTAPKVDAEEREEDASELRCMFCGFLSADVGSNVHHLECVHSFTIPLTAHCTNQAALLAYLARKINGLMCIVCNERTRSFSSLEALRDHMRETNHERLILSPEYQEFYDVVLEDPEAARPVQLEGVRGDELVLAHDKALGKRRVVLKRENDVPRARPRETEEHNEKRMAILAEEQETRALARQEQKELIMAQNKEAAWVAKRSGGDRHNLQLDVSMRTNRLHPKGYDGNMMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFZ0</accession>
    <name>A0A3Q8IFZ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter aATP11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_310008800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFZ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0450"/>
    <dbReference type="OrthoDB" id="277763at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF301">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="111"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="511" mass="55981" checksum="299FD917C697CDD9" modified="2019-04-10" version="1">MPTAATGKSAMPYPNESAHGHEWEYDSPNRDGAELLEEQAYAAEVEGHKKKAAATSEDSQKGVDPFDFSVNSPEQRIARMDRERAERVQRRRTELNFFQRWFSYILPYGGVVASGINLASSCIGAGIIALPSAFNAAGIIVAMIYMVVIAYLTIYSYILLAIVAKKTGLRNYEQIARTLMGPGAGYFLAFCLWFLSFGAEVSYAISLKDVLTAFLDASETAPAYLQTLSGQRVMTFVLWLVAMLPLCLPKEINSLRYFSCVAICFVVYFAIAMVIHSGVNGLQENPRPAVKLFNQGNTAIGGLATFLFAFISQLNAMEVAGEMHKFSVRRMSIASAIGVCICFVLYFFAGLFGYLDFGPKVTGSALKQYNPVKDTMMGVGYGGLMLKLCVGYGLHMIPVRDAIYYVCQTNVHNIAWWKNACVCGSMAVLSLICGLFVPRINVVFGLVGGFSGGFIGYIYPALMVMYSGNWTFSSAGFFHYVCTYLLLFVGVIAVVWGTSAAIFDEVMAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGQ4</accession>
    <name>A0A3Q8IGQ4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_250027800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGQ4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2670"/>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="601" mass="68852" checksum="340DCF8DBE2DEF84" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGT8</accession>
    <name>A0A3Q8IGT8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_280024800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGT8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2590"/>
    <dbReference type="OrthoDB" id="283553at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF8">
        <property type="entry name" value="CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="288" mass="33055" checksum="32B571530F1EB35A" modified="2019-04-10" version="1">MVFSIPSYLGVGDRYKKPIDARAQGATFLVSRPKTGTNPDALFDKELHHFWNGERGGDPEAMRRRQQLESAKKNLTPNGFVYSSPTPEPAGLGSYFGCFQATPYAHVPEYPEKHDQAIAKRELPPRGVYTSPAQKGTGYGYAHVALSDVGSNYIAIIYEQQLINERREREEWKKKMPAEPFRPAGREGFTFDESPATGTSRCYIMTVPFREKRPEPVLTHFRIDQPWRPAGYVEDKPTTIEYWEDPYRGYDPRKEPKEYVKKPSDAVFLPSSLNDNFWYTQSIVFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHG8</accession>
    <name>A0A3Q8IHG8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter aATP11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_270011600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHG8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0870"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF301">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="106"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="500" mass="55568" checksum="49F36633A0D9E185" modified="2019-04-10" version="1">MASKEPNPFHMHNSEPARRQGHGEPMDLRSELDMEVAQGYDAKDVRRVEDVSSAESSHPYNFSRYDPKRQIELQDKIRADRVARRLVPANVFQKYFNYLVPYGGLVSTGLNLASSSIGAGIIALPYAFNASGLVMAIIYMFMIAYLTIYSYYLLGQAGTKTGLRNYEQIVRTLLGPGADYFLAFCMWFLSFGGEVSYVISVKDVLTAFLEDADNTPAFLLNIWGQRLLTFLVWLVAMLPLCLPKEINSLRYFSCVAIVFIVYFVIAMVVHSAQNGLRADPRPEIRMFTTGNTAVSGMSTFIFAFLSQLNAYESYEEMSNPTPLRLTLGATIAVGIVFVLYFLSGLFGYLDFGAEMTGSALKKYNPVKDVMMGVGYVGILFKLCVGFGLHMIPVRDAIYHCVRVDVHTFAWWKNACVCAFMALLSLVAGLFIPSINVVFGLVGGFSGGFIGFIYPSFMVMYSGNWSLSSVGWFHYLSTYFLLIVGVVGVVWGTASSIYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHM9</accession>
    <name>A0A3Q8IHM9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350006800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHM9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0250"/>
    <dbReference type="OrthoDB" id="271812at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="750"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="862" mass="97762" checksum="15577AB00D25A544" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHP4</accession>
    <accession>E9BPK9</accession>
    <name>A0A3Q8IHP4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_10115</name>
        <name evidence="5" type="ORF">CGC21_37300</name>
        <name evidence="4" type="ORF">LDBPK_332710</name>
        <name evidence="2" type="ORF">LdCL_330034200</name>
        <name evidence="3" type="ORF">LDHU3_33.3850</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864095.1">
        <property type="nucleotide sequence ID" value="XM_003864047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHP4"/>
    <dbReference type="GeneID" id="13392491"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330034200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3850"/>
    <dbReference type="OMA" id="FKEQWYQ"/>
    <dbReference type="OrthoDB" id="268405at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="99" mass="11459" checksum="B12784FD351BE16B" modified="2019-04-10" version="1">MGLPGWMRRCEIYAICMVWPIATVVGLVGTYRLFMWSYGGRECFRYVAIQEPFKEEWYQANPKSALGMDTPLSHVPKYLETPGYTVDGATDDHPHHRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIA9</accession>
    <accession>E9BBV3</accession>
    <name>A0A3Q8IIA9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_38610</name>
        <name evidence="16" type="ORF">CGC21_4750</name>
        <name evidence="15" type="ORF">LDBPK_140680</name>
        <name evidence="13" type="ORF">LdCL_140012300</name>
        <name evidence="14" type="ORF">LDHU3_14.0910</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859439.1">
        <property type="nucleotide sequence ID" value="XM_003859391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIA9"/>
    <dbReference type="SMR" id="A0A3Q8IIA9"/>
    <dbReference type="GeneID" id="13391418"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0910"/>
    <dbReference type="OMA" id="IFGIQHF"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF105">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5428609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP53483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="284" mass="32346" checksum="98B5B66414F49DE3" modified="2019-04-10" version="1">MEALDNYLIAHYDGHAVQKWLASNVDISVYIAAAYLTFVFKGPQLVDLIFRGNPPTRLIKMCWTLWNIGLAVFSMYGVYHIVPLFINNLRKYGQKDALCRFREDEFYTGKNGVAMGLFSLSKLPEFGDTFFLIMGGKRKLPFLSWFHHVTIFLYAWMAYQQASSIWIVLASINYFVHSIMYTYFALAEAGFKKLVKPFAMYITLLQIAQMVVGLYFTFSFISYHKADPKGCNGSTMALARGQCMIYFFNLYLFSEMFIKGYVLPRKAAAGDSAAATAPAGKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIC0</accession>
    <name>A0A3Q8IIC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Mitochondrial_carrier_protein_putative/GeneDB:Lmj F.35.3990</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_350045500</name>
        <name evidence="12" type="ORF">LDHU3_35.5250</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIC0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350045500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5250"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF19">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="133"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25250" checksum="0EC994DAFA089A54" modified="2019-04-10" version="1">MNATLQSLRAAAAATPPSVRFFVCGLAAETVSCVVWVPIDVAKERLQSQPPSLKGRYTSSLDALQRILANEGVRGLYKGYASTLSSFGPFSAVYFVFYEYFTKVLAGLHTAASAAPKQGDRNGGNEREIFSLATFAVALGAGAGGNAVASLLTNPLELVKTRIQVQRAVLHRRDVGASTPALFSYHYRGLREGLGALAKEKGIRALWKGVGSRIAYTAPNAALTMGFFEFLKTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIC3</accession>
    <name>A0A3Q8IIC3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CGC20_3930</name>
        <name evidence="1" type="ORF">LdCL_310010300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIC3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0710"/>
    <dbReference type="OrthoDB" id="269552at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TPP41576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="242" mass="26122" checksum="A66A3B431D68F07F" modified="2019-04-10" version="1">MAAPSRDCASRPSLDAGIFFPEGSRPPQPLHGHGFLLHGARAVGKTSLAFQAAINTVQRAGGSVVVLCQESTLYAKVPQPFTPLSSLSESALGHIEFIYVEGWTAALREMMGFRTTRAVPALLIVDDDGFEVTVPADGRGKRSGQYLDFLVDTAAASCLSYLENLHDWMTRHDRPFFYILVTNHLPESATQLSLPYAAFPLVNVWVGASGTVQITTTQAGGTAEVVSPPAYLTWQNGLRMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIH2</accession>
    <name>A0A3Q8IIH2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase, putative</fullName>
            <ecNumber evidence="5">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_310018100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIH2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1870"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08021">
        <property type="entry name" value="M20_Acy1_YhaA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="197"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="405" mass="43982" checksum="30EDA86B068D491B" modified="2019-04-10" version="1">MPAINREELDRRVEQIYDQVVAWRRYIHENPDLSFEEQPTAAYIMGELQKMDAEGEWLHISQPESNCVVADLKGGGGDGPIIALRADIDALPVEELTDVPFASKKQGVMHACGHDTHAAMLLGATRLLLEDAGRIKGTVRLLFQPAEEVPPGGAQMMIEKGCMEGVAMVFAEHIVPMKEGPTGTVLVRKGPVLSSSDTLHAEIIGRGGHASMPESSIDPIAIACLAVTALQQVVSRRMPPSKCPIFTITTIASSSDSYNVIPDRVTLKGTLRTQDREVREDAKKAVAEVLHGICRSYGATCNLSWLPGYDVTVNTDSAYDVGMRVLAQVLPSKDQVVELSACMSPSEDFSEFAKVAPANYVGIGCYNPEKGCTAVNHNAKFRVDEEAMKVGVKVHYGTIHELLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIX3</accession>
    <name>A0A3Q8IIX3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290027100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIX3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3020"/>
    <dbReference type="OrthoDB" id="262539at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="369" mass="38410" checksum="4B16C2A21BD7C6A7" modified="2019-04-10" version="1">MPVSRTAGRCVAVQRRFLGLSALSPSNSNSALVHSARFTCTAEADRDQAFSGLPTDVCADTSFERFRGPDSGSGRGNRCNNSPKRGGGTAAGLGRSQGSSKVHVFSRPAQQLSAAQLAHFTHLRGLLRRLSSLRQASSNAVEAASRAAAAHHLLSREGESGSKSPQTRTSTAPVDSLHSELFVVSRVVASPHHHALSAESGAAACGDEVFTGVNHAFHKRINPAGATLRGILKGCAEQNALGAAAASGCIYADVADVFLLAVRCSPMTSYHALESGEKAAAPASATCSSCATACSDAGPAAAQAVAIFPCPECWNHLCHVARARLQEERTPLRLFVYAASPAVTVHLFAVAQQRVKMMEAPVDVCIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ47</accession>
    <name>A0A3Q8IJ47_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WW domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_160017000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ47"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1450"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000119">
        <property type="entry name" value="WW_domain_containing_protein_-_putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="646" mass="68081" checksum="DACA77632770B708" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJA1</accession>
    <name>A0A3Q8IJA1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_350040100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJA1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4590"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="369" mass="41688" checksum="12FD80844F7784C4" modified="2019-04-10" version="1">MLLHHALSNTQTPFGCPIVAPENYREEAEEIADFIWKLSTDQPMYTFPDLWAMFTAKAMARLGGPNVVPLRGRDDPPEFMTRDLLLAFPRSLVHEDDRDVLNMKRVLSRQGFSLEQVVALIGCNRCIGFHDAANFHTREEVKPKMKRRPGAIGPSDDEFHLPGTIQKTTMDPYVFGSEYFNLLLDYKWRQPGLFQQRRKGAYSCNAKERARQVTLLDPFSEKSYESQQRRMGPAEKARESSNATDKRIPATLGDGDSAPDRGRFDRSGEAQFIPGAHSANRSDSAESSNREPDIAGDPDYEAERGTVSVDPCEHVSMRGVDVMLLDDALTKGWLYQFGDNELEFYAAVSEVILNIQGRGYNPNKLAMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJQ2</accession>
    <name>A0A3Q8IJQ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_300040100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJQ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4580"/>
    <dbReference type="OrthoDB" id="272049at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="234" mass="26074" checksum="39D0A2F23104AB59" modified="2019-04-10" version="1">MKLHLEDAYEELCAEYNTTPLCTFRSSLRNTYASLDGEVFMDASYVEGDHFCVFAELLRRLLRRPIAFIQPTIVQLDTAAPQLEHSVLYAPEEQVGHAYYAVPPRLLRIKLLLSRNVNNADVERVCRLIVVQKVLDCVPFPASHSNSTKASVQATGTLPQLSWPERATIESIDLHNCVFVSLPGGRALRAAARRNVYVQNVFLEGCSVNAAVVAQIARATRGNREQFRLVGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILT6</accession>
    <accession>E9BUX9</accession>
    <name>A0A3Q8ILT6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerophosphoryl diester phosphodiesterase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase, putative</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl_diester_phosphodiesterase_putat ive/GeneDB:LmjF.36.5960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_15380</name>
        <name evidence="4" type="ORF">LDBPK_366220</name>
        <name evidence="2" type="ORF">LdCL_360069600</name>
        <name evidence="3" type="ORF">LDHU3_36.8260</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865734.1">
        <property type="nucleotide sequence ID" value="XM_003865686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILT6"/>
    <dbReference type="GeneID" id="13386588"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360069600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8260"/>
    <dbReference type="OMA" id="VAHRGCH"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08566">
        <property type="entry name" value="GDPD_AtGDE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032160">
        <property type="entry name" value="DUF4996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16387">
        <property type="entry name" value="DUF4996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="316" mass="35963" checksum="4A16B6512F718226" modified="2019-04-10" version="1">MRSASTMCQRWPQHTNIAQDNQAHHKPLIQRFVRDGANPRPQLRFLLHSPDSKFPVCVACHRGDWRNYVENTLEAVESCIQMGADIVEVDVWRTSDGALILMHDETLDRTTNGKGRVCDHTLAEVRALRLKDGLGNMTEFTVPTVEEVLLLAKDRVILNLDKADVYLDELYPLLVKTGMVEQTILKSEIPFDELCKRYSADLLNRVIFMPILNITDTTTYESIDRAFAANHALYEVNFEKENADMLQYIRKLAKNSGAALWINTIWPTTCGGYSDDHALRDKDANWGYVVEHIGAGIIQTDRPAMLLAYLQERGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPR2</accession>
    <name>A0A3Q8IPR2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_360066100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPR2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360066100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7770"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000133">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000069">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="38"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="729"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1100" mass="125978" checksum="EFD3977077DEC648" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IRG0</accession>
    <accession>E9BUE6</accession>
    <name>A0A3Q8IRG0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, putative</fullName>
            <ecNumber evidence="3">1.6.5.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Zinc-binding dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_14470</name>
        <name evidence="4" type="ORF">LDBPK_364380</name>
        <name evidence="3" type="ORF">LdCL_360050900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865552.1">
        <property type="nucleotide sequence ID" value="XM_003865504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IRG0"/>
    <dbReference type="GeneID" id="13388438"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360050900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5920"/>
    <dbReference type="OMA" id="VDMSYSR"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="340" mass="36182" checksum="58AB1851E1804D43" modified="2019-04-10" version="1">MSSPSSFKKLQVVSLSKDFRSSTSVVEAQLPEEVPEGMVRVSVKYAGVNASDLNFTNGSYLKNARPPFDCGFEAAGTVVKIGAGVANVKEGDPVVLMQYGCFAEFLDAPAEICIPVPELKPEYIVLPVSALTAAVALGEVGRVKKGDVALVTAAAGGTGQIAVQLLKHVYGCTVIGTCSSEEKARFLKSIGCDHVINYKTESLDSRLHMLCPKGVDVVYECVGGQTFNDAVRHVAVHGRVVIIGSISSYKSGEAVPFSHPSGTSMTMLLLTKSASLNGFFLPQFYDVIPKYMASLLQYLKAGQVKLFVDEKVFHGLSSVADAVDHLYSGTSCGKVLVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IUU0</accession>
    <name>A0A3Q8IUU0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340039300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IUU0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5180"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8517" checksum="6762A214E5DABC57" modified="2019-04-10" version="1">MASSFEPMPNIPSFWLAGSPNGELCGDVTVLHGLQGALLDPTVGKNGMAMRLLFRGVVETHKASRELQNGAVHRSQRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IWM4</accession>
    <accession>E9BV34</accession>
    <name>A0A3Q8IWM4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin fusion degradation protein UFD1 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ubiquitin_fusion_degradation_protein_putative/Gen eDB:LmjF.36.6490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_18860</name>
        <name evidence="10" type="ORF">CGC21_38615</name>
        <name evidence="8" type="ORF">LDBPK_366780</name>
        <name evidence="6" type="ORF">LdCL_360080300</name>
        <name evidence="7" type="ORF">LDHU3_36.9040</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865789.1">
        <property type="nucleotide sequence ID" value="XM_003865741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IWM4"/>
    <dbReference type="GeneID" id="13386643"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360080300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9040"/>
    <dbReference type="OMA" id="KPRFQGA"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU84083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5435266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP49495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="325" mass="34658" checksum="4EAD9628389ADD32" modified="2019-04-10" version="1">MAALPQPYETRLVAVSASSVHQQRINYGSRVLLPSSVLDDLCRITMVYPLQFEIITPAKKRVYAAVLEFNAQAGSVVLPDWMFQHLGLCGTMVVKVQSCSLPPGSLVKLRPHQKALVMFENPRHLLELRLAQYPVLTKGTTIVISYVDREFQLDLVDIIDMKQERVNGILTVRADGAPVELKVDFERPLDMPPSPPETPTSAVASPTGANVIGASSPTGVQFQPFNFRPPSLTDATKVAAGTPPLKHLPGQSSSPSSGPKGSNSAAEPEQPTFAGAGRTLRGILSSENQTNEASASAPAAPPAARPSAEELRAIRLKALGGGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Z0</accession>
    <name>A0A3S5H5Z0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070012200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Z0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0890"/>
    <dbReference type="OrthoDB" id="273174at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="519" mass="54793" checksum="974AAE723D4244DE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H607</accession>
    <name>A0A3S5H607_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_070015400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H607"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1270"/>
    <dbReference type="OrthoDB" id="263268at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="336" mass="35175" checksum="C77BCAC04B0A3E1B" modified="2019-04-10" version="1">MDEYVCTSCGTPACLVLSVSPALPSSSTVLADKARIPPQEGGLLGALPPLMRFCIVCGHELAPRSRVPPHKKPAGSAAVPRPKQRPVAAPNSSSEPLVAPTAMVSVATMHAAVVALTRQHQAERMTLQQEMDQLKAVLAAVLERHPSLSESERAPAKAVVPAPHSGDAPSFESDCGCGAHHGRSDSCFSSGHCRTRSPSIVLPASCLAGPGISPGEAAGTLATTAGNASMPLQQCAPPRCSRTLPRHSCSYDSDIAVSEWAAAAAVAPTQLEARLNSGCSASLLDSERTRRSALLTQQVPFPVAPLRRSSDDGELDSHQPQQDEHARLREALLQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H667</accession>
    <name>A0A3S5H667_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_080012100</name>
        <name evidence="4" type="ORF">LdCL_080012700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H667"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0990"/>
    <dbReference type="OrthoDB" id="244479at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22731" checksum="1E6C97DA698D1CD4" modified="2019-04-10" version="1">MACKLGVIIYVVLQFIAFFSVLIGTGVDMFYIKPEHSFGIRVCITLWGGKTDCRKANVTISSDTRWKFCPIRRNNFRIGQAFAVISIFVYGAAFLFGFLLLYCCAGFRWLCLALNIVGAVTACVVWAVMVVTYRLPEPKCLELSDGYDFGTGFGLFVLAWILDIIDVIFLMLPWQIGESGKGDEPNVQEEEEEEVGSKEATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6N0</accession>
    <name>A0A3S5H6N0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_130007400</name>
        <name evidence="5" type="ORF">LDHU3_13.0290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6N0"/>
    <dbReference type="SMR" id="A0A3S5H6N0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0290"/>
    <dbReference type="OrthoDB" id="10264298at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5428393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="307" mass="35718" checksum="E9B5EB4E9F21D4E7" modified="2019-04-10" version="1">MSSALDSITAATKLRRAEIDVQRELEAKREEYNRRMAQVKEGEAQLAADRAELQDTLVQYYKFIQENEIKRSRAMKKVAIEEKQRKEREAYIAQLTQRLQGLEQKRDEMKTQYEDIEKYQTFLEEVLSRNDGDEYQEPRDIMKRWMTLCDNTSVLQARKTQLEEDLLRTRSSLNLARQRRGTENIALQNQLNEMQMSFESLQKAIKAKQDKLDRMIKQKSSTTRTVSHVSMATANLYDRCVSWVRDYSGRGKVETLHSNVLHQLHVICDCLEDFQNIIMQHQEQQRQVAAQQVAAAAAQQAAVAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6S6</accession>
    <name>A0A3S5H6S6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">LdCL_140017000</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1430"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000022">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="17">
        <location>
            <begin position="692"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1243"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="22">
        <location>
            <begin position="1907"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="23">
        <location>
            <begin position="2201"/>
            <end position="2289"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="20">
        <location>
            <begin position="2362"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="19">
        <location>
            <begin position="2637"/>
            <end position="2967"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="21">
        <location>
            <begin position="2994"/>
            <end position="3220"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="3558"/>
            <end position="3671"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="3732"/>
            <end position="3830"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="3939"/>
            <end position="4264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1605"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3828"/>
            <end position="3847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3866"/>
            <end position="3890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3920"/>
            <end position="3944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2638"/>
            <end position="2693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2851"/>
            <end position="2934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1609"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3829"/>
            <end position="3841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3929"/>
            <end position="3942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="AYU77362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4268" mass="472840" checksum="F2C437F07D0147FC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6X9</accession>
    <accession>E9BCU0</accession>
    <name>A0A3S5H6X9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_24930</name>
        <name evidence="8" type="ORF">LDBPK_160870</name>
        <name evidence="7" type="ORF">LdCL_160014000</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859774.1">
        <property type="nucleotide sequence ID" value="XM_003859726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6X9"/>
    <dbReference type="GeneID" id="13393128"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1040"/>
    <dbReference type="OMA" id="EYGVFTD"/>
    <dbReference type="OrthoDB" id="1924919at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002921">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF103">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="348"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP51154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="687" mass="75227" checksum="BD31ECFE6A355D75" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H756</accession>
    <accession>E9BE45</accession>
    <name>A0A3S5H756_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_19340</name>
        <name evidence="4" type="ORF">LDBPK_190500</name>
        <name evidence="3" type="ORF">LdCL_190010000</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860228.1">
        <property type="nucleotide sequence ID" value="XM_003860180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H756"/>
    <dbReference type="GeneID" id="13386040"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0550"/>
    <dbReference type="OMA" id="RCYVAPS"/>
    <dbReference type="OrthoDB" id="272083at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33049" checksum="70361BA74B737EDE" modified="2019-04-10" version="1">MEDTINVFGRGTPAGEAIYRCYVAPSKPSTLDPQLAALLARRRQEREAAEAVQAHPKPIPKSKAPVRRPRVGLGRRPTEEEYARWRLQHIPHRRSKAAIEAEEEAHRWVPQPVSDRFARPAITDAEKDRLADVMAYGAELPKPKEFTGAQRVRLHRLEPRAELEDRFAKLRQTAQEVQSELAQLRQSAPGIVASLPSGGRVAESVLDPQTRLSQRRSCEGGSDSATTSPCPLVSAASPGAAAARDVLSIGGTRVSHQGDSKMSTIERCRQERELQSHLGTVIAEMEAVDRELNRLPIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7D0</accession>
    <name>A0A3S5H7D0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_16080</name>
        <name evidence="2" type="ORF">LdCL_240014000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7D0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1060"/>
    <dbReference type="OrthoDB" id="247796at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP52221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="117" mass="13040" checksum="5BB896714C2C09B5" modified="2019-04-10" version="1">MNGWLIALIVMGCLSTLYLAIGIAVRYHSGLHHCPEVLPNYRFWCSILNVFLRVATCGRCRVSIDRSNRASGIFVLPSRPGAAASPRRVQFELLASDADDDYNINRAMQPAEVVVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7G0</accession>
    <name>A0A3S5H7G0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260014900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1190"/>
    <dbReference type="OrthoDB" id="264118at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1709" mass="184877" checksum="13C6D05E01177417" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7Y8</accession>
    <name>A0A3S5H7Y8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350017400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7Y8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1660"/>
    <dbReference type="OrthoDB" id="271974at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="847" mass="96148" checksum="F641D5DCE27D2B2A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNY1</accession>
    <accession>E9B872</accession>
    <name>A0A3S7WNY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_2955</name>
        <name evidence="2" type="ORF">LDBPK_041070</name>
        <name evidence="1" type="ORF">LdCL_040016400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858169.1">
        <property type="nucleotide sequence ID" value="XM_003858121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNY1"/>
    <dbReference type="GeneID" id="13391017"/>
    <dbReference type="KEGG" id="ldo:LDBPK_041070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1330"/>
    <dbReference type="OMA" id="CFATITR"/>
    <dbReference type="OrthoDB" id="272803at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP51523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="129" mass="14118" checksum="F4E39FD0169B8E95" modified="2019-05-08" version="1">MWPFSSAAANTRSSSSIEASLPLERRLIRVSKADISRVTADDIKRVSARLTNDELTTSLRLLVETNRLGDVLASASSSAWAEAVAEVTEARMGLSSNVMRDRMSLLYNILPYVSDNFLSAMGSSYSRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPS2</accession>
    <name>A0A3S7WPS2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_070007400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPS2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0300"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="15">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU76192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12187" checksum="0294A4315FB4D8FD" modified="2019-05-08" version="1">MSSSATSTQAFSLKTRQPIPDEDALLTEEDRILKQATKGEDCTTRRRACKNCVCGRAELERKLEAEALAMPPGGCGNCSKGDAFRCANCPFLGQPAFDATEDGKVKLNLTDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQJ9</accession>
    <name>A0A3S7WQJ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CHASE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_18380</name>
        <name evidence="3" type="ORF">LdCL_090008700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000045">
        <property type="protein sequence ID" value="TPP41909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQJ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0470"/>
    <dbReference type="OrthoDB" id="272956at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="114535" checksum="0A7A3ECB4448C804" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSI1</accession>
    <name>A0A3S7WSI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130014000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSI1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1080"/>
    <dbReference type="OrthoDB" id="267037at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="643" mass="67867" checksum="A0E03EB312AAFA70" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSK5</accession>
    <name>A0A3S7WSK5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130012800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSK5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0940"/>
    <dbReference type="OrthoDB" id="267867at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1085" mass="111966" checksum="82419AB5E0C4B073" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT13</accession>
    <accession>E9BBW5</accession>
    <name>A0A3S7WT13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_4820</name>
        <name evidence="5" type="ORF">LDBPK_140820</name>
        <name evidence="4" type="ORF">LdCL_140013700</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859450.1">
        <property type="nucleotide sequence ID" value="XM_003859402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT13"/>
    <dbReference type="GeneID" id="13391115"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1060"/>
    <dbReference type="OMA" id="ISHAMGM"/>
    <dbReference type="OrthoDB" id="251992at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002139">
        <property type="entry name" value="GTP-binding protein YPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="417" mass="42870" checksum="0482A5847C2C5699" modified="2019-05-08" version="1">MDKQDDARDAGHLQDMESVATAHRASVIGAPSSSLVTASHAAASSIVSVGGPSTSFDAGAIAPPASSTHVASPRPLSISIGSDAFANAGGALLMPSAVGRHNEFLRTYKVLIVGEAGVGKSNLMHRYCYNEYDPALPSTIGVEFCSREVGIPSGPVGVTETVVLQLWDTAGQERNAGVISNAFYRNAVGAIIVYDVTRHESLLSVPRWAAQVTQLARDNCVCVVVGAKLDLLDANAAATSTTAGSLEALQQEADRISHAMGMRNFMTSALSGQGVLEAFTHLILAVDAVQAASLHNNGIFSGRYQTRCSSHVSGASVREAQMQTAAAVASASSADLTDGAEGRRGWPDGDGASLSLSRVVSTPLVSGYTGASPSAGRLQRQPSSQAKKTLDLRGFGSSEAGSGAYEASPTCSGGWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT21</accession>
    <name>A0A3S7WT21_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial DNA polymerase I protein C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_140015500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1250"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF23">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1548" mass="170126" checksum="84F01089AC250AA2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV76</accession>
    <accession>E9BDY6</accession>
    <name>A0A3S7WV76_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_181550</name>
        <name evidence="1" type="ORF">LdCL_180020800</name>
        <name evidence="2" type="ORF">LDHU3_18.1960</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860169.1">
        <property type="nucleotide sequence ID" value="XM_003860121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV76"/>
    <dbReference type="GeneID" id="13393457"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1960"/>
    <dbReference type="OMA" id="MSPFEEH"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5429372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="563" mass="62932" checksum="D70BF3D68E0FAD7D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVI6</accession>
    <name>A0A3S7WVI6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transport system ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_190013000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVI6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0880"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002099">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="75"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="389"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="612" mass="68336" checksum="2EEA412A5C0FB418" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVX4</accession>
    <accession>E9BEN4</accession>
    <name>A0A3S7WVX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_31650</name>
        <name evidence="6" type="ORF">CGC21_29395</name>
        <name evidence="4" type="ORF">LDBPK_200870</name>
        <name evidence="2" type="ORF">LdCL_200013400</name>
        <name evidence="3" type="ORF">LDHU3_20.1080</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860427.1">
        <property type="nucleotide sequence ID" value="XM_003860379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVX4"/>
    <dbReference type="GeneID" id="13386213"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1080"/>
    <dbReference type="OMA" id="IHQPHFM"/>
    <dbReference type="OrthoDB" id="270953at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="346" mass="38302" checksum="288C21F258C564D7" modified="2019-05-08" version="1">MQRDSYATIVRYPNRRKFPVRVLQMNGAVFHENLIEDFFIGYRNRRLALMTHTPGQDPRLPRLPKDIIVPNYKTFLQIHQPHFMYRLLPLLSSDVEAFAAMQAICASPGSPFTIEDRLESQLLNYRLSKLCAGRDKICEFFKDYTTQEELRMPSATRALPIQGIFFQGLMLRDGCVATTSHTRALTPAATAEAAAASSSTSTGDSGRKPSGAAGPIDDGAVVAGSTDGGLNGGLQTSYKKRVKASIAALLTTHDVLSEAVITQRALMAKFFESDLYNQFGTASTIAAKVRSVDERMHFMAVKRLCAGRTNTAENVRTRAHLLELARKQNLHVYEKISEGEYAYAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW32</accession>
    <name>A0A3S7WW32_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_31365</name>
        <name evidence="5" type="ORF">CGC21_29120</name>
        <name evidence="2" type="ORF">LdCL_200019500</name>
        <name evidence="3" type="ORF">LDHU3_20.1850</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW32"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1850"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF136">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600655" evidence="1">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="340" mass="37413" checksum="EBA65A92703874E4" modified="2019-05-08" version="1">MLHRSFWRLTAAAAASSAASGETLAPFTARVGALCKQMRAAGAEFGCVAVDPSEEQCRGLVAKCALREGTTVMSVPLQSCGISSEQLIKDNAFVQAMKPPSLNVVRHLMNTRSIRDPVMHEQFYLALLIAADHMNPASPRSDYYNLLPHPAIDDALVIQRHKDVLDPLLLVEWDDYQKEMLSVLHHLLRRWGSPLAPPIQVAYWALRTVLSRMHMLPKAGLAPQQVGSALSYTALYAVDQADLQTRWRRRFKSILSSLTGNPADAEEYHLVPTLVPLLDMTPHIPSSNVQVEVNTRGAAVGGCAELRAVRDIDAGETIGLRFNASQAPAFLLFRFGFIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW41</accession>
    <name>A0A3S7WW41_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200016900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW41"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1550"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="187"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="743" mass="82458" checksum="A7E1FB96CD834873" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX62</accession>
    <accession>E9BFU2</accession>
    <name>A0A3S7WX62_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CGC21_2295</name>
        <name evidence="18" type="ORF">LDBPK_220750</name>
        <name evidence="17" type="ORF">LdCL_220014800</name>
    </gene>
    <organism evidence="17 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 21" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860823.1">
        <property type="nucleotide sequence ID" value="XM_003860775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX62"/>
    <dbReference type="GeneID" id="13389388"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1210"/>
    <dbReference type="OMA" id="LEGFVRC"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600662" description="EF-hand domain-containing protein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="754"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU78791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP46989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="884" mass="94037" checksum="89E83BFD49F6AAC6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY34</accession>
    <name>A0A3S7WY34_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rtr1/RPAP2 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240009200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240009200"/>
    <dbReference type="OrthoDB" id="265640at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1429" mass="153462" checksum="D7FB7851A039E774" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYX4</accession>
    <name>A0A3S7WYX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250012200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYX4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0850"/>
    <dbReference type="OrthoDB" id="273579at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1058" mass="112741" checksum="92FC5118BEA33A13" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ63</accession>
    <name>A0A3S7WZ63_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial RNA binding complex 1 subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_250021700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ63"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1980"/>
    <dbReference type="OrthoDB" id="189459at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046834">
        <property type="entry name" value="ABC_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046833">
        <property type="entry name" value="ABC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049069">
        <property type="entry name" value="MRB1590-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149:SF1">
        <property type="entry name" value="ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20446">
        <property type="entry name" value="ABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21117">
        <property type="entry name" value="MRB1590_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase of the ABC class N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase of the ABC class C-terminal" evidence="2">
        <location>
            <begin position="282"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="MRB1590-like C-terminal" evidence="4">
        <location>
            <begin position="607"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="747" mass="80425" checksum="01212302123F1B5B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ87</accession>
    <name>A0A3S7WZ87_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250024500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ87"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2320"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1032" mass="106179" checksum="80531E2A678E89C7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0X5</accession>
    <accession>E9BJD1</accession>
    <name>A0A3S7X0X5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_32315</name>
        <name evidence="5" type="ORF">CGC21_30420</name>
        <name evidence="3" type="ORF">LDBPK_272010</name>
        <name evidence="2" type="ORF">LdCL_270027400</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862052.1">
        <property type="nucleotide sequence ID" value="XM_003862004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0X5"/>
    <dbReference type="GeneID" id="13386787"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3090"/>
    <dbReference type="OMA" id="ADLPMMY"/>
    <dbReference type="OrthoDB" id="269191at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="148" mass="17434" checksum="341087AA780D5675" modified="2019-05-08" version="1">MNPNESNTGHKVLIADLPMMWPSDMRRFEKEGGVWGRQFRQRRRQLTFALTVSAATTLLGSWYVVMRRRNTYFVLFSTFSGFSVLGFCVGMSLAPLWYENVANNKETSMMRRVWWAKECAKHWDYSQVNKERWIASYPKAAYPCKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1P6</accession>
    <name>A0A3S7X1P6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280026600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1P6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2930"/>
    <dbReference type="OrthoDB" id="272389at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="550" mass="60014" checksum="3956EA05A088F329" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1W2</accession>
    <name>A0A3S7X1W2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SelR domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_280033700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1W2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280033700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3850"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="7">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16526" checksum="C906AF972ABBD7E1" modified="2019-05-08" version="1">MTTPLTNCAGPKEKDGSKDMSDEEWRRILTAQEYHILREKGTDPVGGKYDDVFDEGEYVCAGCKTPLYLSSMKFACGCGWPGFYDCIPKRVREQPDKDGRRVEIVCNACNSHLGHVFRKEGFRNPPPNERHCVNSTSIILRPTQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1X0</accession>
    <name>A0A3S7X1X0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280032800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1X0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280032800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3750"/>
    <dbReference type="OrthoDB" id="273192at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="226" mass="23881" checksum="E6D1759F77DEFC6D" modified="2019-05-08" version="1">MHDDQLRFFRRYTRVFPATAYARHTPRVGCSVATDARSTTCTSLSSAASRTSCVKILALLCSKEPSQATTADTTPEKCSALPTSAHSLAVSHKRTRGGCVDSRDASALEQTSTASPEPPRGGEVKRVRSDTDGVSAPAESSGSPTTAASSAAIKQEAETRTTVTNAAEGNAAAAASCDTTEPTPTASLYVRVQYDKAVITTLPIEVMRVQHPQVLIDYLLSMSVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2U5</accession>
    <name>A0A3S7X2U5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine-adenosine-guanosine-nucleosidehydrolase, putative</fullName>
            <ecNumber evidence="5">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_290035200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2U5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4250"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF46">
        <property type="entry name" value="INOSINE-ADENOSINE-GUANOSINE-NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="333" mass="36600" checksum="21DDB6BF9926467F" modified="2019-05-08" version="1">MPPKPVIIDHDGGHDDLVALALLLGNPEAVKVIGCIVTDADCFVDQAFNVSGKLMAMMHAREATELFPVAKTSFKGVNPFPSDWRWSAKNMDDLPCVNIPEHVAIWEAVRDENDKLVGEEAMAQLVMSSPEKVTICVTGPLSCVAWCIGRYGEEFCKNVEECIIMGGAVDVKGNVFIEGRTDGSAEWNIFWDPAAAKTVLMCPHLKKIVFSLDSTNSVPVTSEVVQKFGAQNKYLLSQFIGSAWASCTHFELIRPSDGYYAWDVLTAAYAIERRLVELEAVPLEVVVEANAPNEGQTRRAFEGAALDHTYVAKNTKTDLFYRMVMDSARCCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3Q6</accession>
    <accession>E9BM39</accession>
    <name>A0A3S7X3Q6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_36185</name>
        <name evidence="3" type="ORF">LDBPK_302960</name>
        <name evidence="2" type="ORF">LdCL_300035200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863007.1">
        <property type="nucleotide sequence ID" value="XM_003862959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3Q6"/>
    <dbReference type="GeneID" id="13385716"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3930"/>
    <dbReference type="OMA" id="RMNLRFM"/>
    <dbReference type="OrthoDB" id="271973at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600673" evidence="1">
        <location>
            <begin position="30"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="340" mass="36508" checksum="2584ED805C42E22D" modified="2019-05-08" version="1">MLQPCVPQLSAALCVMAVVVLLGCVTAQAQENCGTTALCKPYDTNGPACARKKRMNLRFMLQTSRENNFTVGTQVHHLATYSFCPIVDQLSSFTLISAPFMTSCYITKDETSGAVTDHLSMDMGPRYLSVYGFGASNSTLYPQKGVSTGTVLIAVNGTDHTGVSNSVGIVTMLSLEIGLHNGLFNYVGAAAASETTVANPNYDSVLCKNGTVPPAGINYCDKNITIPVAATVVQPAKVGFAPTCNAEDVCTLGDPSVYTCIGEVPGQKNCGVYRTDPTDIRKLQMTVWVSYYGTDWRRNVLTSGGRNPLNYLTFVKENALQTLANKIDSLFHGNFSDRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3U9</accession>
    <accession>E9BM76</accession>
    <name>A0A3S7X3U9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Serine/threonine phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_36350</name>
        <name evidence="4" type="ORF">LDBPK_303330</name>
        <name evidence="3" type="ORF">LdCL_300038900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863044.1">
        <property type="nucleotide sequence ID" value="XM_003862996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3U9"/>
    <dbReference type="GeneID" id="13385753"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4420"/>
    <dbReference type="OMA" id="ATWHVQL"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF6">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="371" mass="40139" checksum="F7B0A4E8F728C23F" modified="2019-05-08" version="1">MASLWKKSLSLLLSAALIIAAFAVALSAEARRLVAVGDLHGDYEQSVSVLRLARLIDNRNHWIGEDALLVQLGDILDVGPDDILIVRLLMRLQQEAHAKGGDVIELLGNHELRNFRGDYKAVDKASLAASGGQKGRDVLLSNATDLGRYLRTRKAIFHYGPFLFMHGGFSTATAGMITSLSKVEEFNSELTKALMNGTISPLARGGLDLTEDDVDDVANPILVRSILNVKCNALSKVLDKKFPGIQSVVVGHVPHDPRDFDGWRLCGGRIIDIDFGMSRWKKGDPGHVAALEIEEATWHVQLIETSTASSSVSGTHAPFQDSVAAYYLVSFSALIVVCVASVLLAAYYLPLCSGAAREPLLKVGTNYYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X505</accession>
    <name>A0A3S7X505_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310039500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X505"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310039500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5330"/>
    <dbReference type="OrthoDB" id="266168at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="521" mass="57195" checksum="5BC5C13A0660F4C9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5P2</accession>
    <name>A0A3S7X5P2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320028500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5P2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2880"/>
    <dbReference type="OrthoDB" id="244074at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="611" mass="65921" checksum="F3AC63282CA8FF3E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6A8</accession>
    <name>A0A3S7X6A8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330009700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6A8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0660"/>
    <dbReference type="OrthoDB" id="259617at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="231" mass="24063" checksum="5A454987C8009C11" modified="2019-05-08" version="1">MHQQQQGAALSSSHDAAPLQPHLPDGSVEDSTSAVRIADGVSVMRANSMNSLFSFSPSGDFTWWSGTIPGLLACCALASMIIIGVCSSQRRAPAVLALMSAQQCSFLSSLQPPVAYMAWMNTCGAAHRGYAYPCMSQVDCVVLGPRCAPPSVLPQLLCVNTGARADHHPVCAYPTPSPTDAPKHSGFCTEPGTSCAICAAETCRSTTTLSGLVGCPPTSACNNDSWLCNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6B6</accession>
    <name>A0A3S7X6B6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heat shock protein 83-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_330009000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6B6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0550"/>
    <dbReference type="OrthoDB" id="276124at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="700" mass="80481" checksum="58E8279D6FD170A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6K5</accession>
    <name>A0A3S7X6K5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330015900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6K5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1510"/>
    <dbReference type="OrthoDB" id="267658at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="549" mass="58366" checksum="204DB3F3ABC18D20" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6T0</accession>
    <name>A0A3S7X6T0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_330022700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6T0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2450"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF47">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20537" checksum="6724D16072FFB7FD" modified="2019-05-08" version="1">MSDISIAAKVQQLYHVSRQHVMRNFMALRPWSEFFDTTFFHSPSGVTDTVNRLNRNLPYFYANYLVLSLLCSSYILLINLPFAVYAVLMVTWYLFIRSRSAMVAALAAQGASEEEQMVYIANRAFTISQLYLMLIVFAVVGFYLTSGSSVIFWLLLTSFGVSVGHASMRRPPIQDSAFDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X721</accession>
    <name>A0A3S7X721_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_330033600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X721"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3770"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000376">
        <property type="entry name" value="Putative UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="571" mass="59961" checksum="9B9D4DAD21B74E40" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8Y2</accession>
    <name>A0A3S7X8Y2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8Y2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1090"/>
    <dbReference type="OrthoDB" id="263350at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="520" mass="58612" checksum="E4FF2A59FBD601FB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9D5</accession>
    <name>A0A3S7X9D5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-protein ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_350029900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3240"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="1922"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1716"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2185"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1744"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2185"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="2277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2310" mass="250907" checksum="3891B21FFB5FF29A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9T6</accession>
    <accession>E9BSQ7</accession>
    <name>A0A3S7X9T6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_14815</name>
        <name evidence="4" type="ORF">CGC21_7385</name>
        <name evidence="3" type="ORF">LDBPK_353870</name>
        <name evidence="1" type="ORF">LdCL_350043800</name>
        <name evidence="2" type="ORF">LDHU3_35.5040</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864966.1">
        <property type="nucleotide sequence ID" value="XM_003864918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9T6"/>
    <dbReference type="GeneID" id="13387843"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350043800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5040"/>
    <dbReference type="OMA" id="FRHAYCL"/>
    <dbReference type="OrthoDB" id="268709at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="316" mass="34899" checksum="D4CA5D22BEA655CC" modified="2019-05-08" version="1">MGGVRIARCNPKLLDFVTWAVMKGCRLFQRVHVTPLGLVATERIPEFDFVAVVPVEATQSLLSIADDPSFALKVSAERHGEPVPFWEDLTRGSFVFLGFLTKALLTGHPRGVQTYLDVLPFDPAMPIGKVADAAQTTKGYKEWAAPLVAQCKVEESDFDAAFRHVYCLFRRHAIPFWSTSDVGGSGHPYFRQFPYARRGQGELMGMVPVMDLALHSPQPNAMIGYPDEEMLQWLSLHKKAAVQQEKGYFVMQAFRDIEEGEVISVNKNAYFNFDDDAFEAWFGYPNVSQVSAEGSGELGSGSKSNGGEGAAVNCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA80</accession>
    <accession>E9BT93</accession>
    <name>A0A3S7XA80_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_29745</name>
        <name evidence="7" type="ORF">LDBPK_360340</name>
        <name evidence="5" type="ORF">LdCL_360008400</name>
        <name evidence="6" type="ORF">LDHU3_36.0460</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865151.1">
        <property type="nucleotide sequence ID" value="XM_003865103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA80"/>
    <dbReference type="SMR" id="A0A3S7XA80"/>
    <dbReference type="GeneID" id="13388036"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0460"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000100">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="206" mass="23017" checksum="107A5F559C2611D5" modified="2019-05-08" version="1">MAETAIAFRCQDYVMVAAAGLNAFYYIKITDAEDKITQLDTHQLIACTGENGPRVNFTEYVKCNLMLNRMRQHGRHSSCDSTANFMRNCLASAIRSREGAYQVNCLFAGYDMPVSEDDDGAVGPQLFYLDYLGTLQAVPYGCHGYGACFVTALLDCLWRPDLTQQEGLELMQKCCDEVKRRVVISNSYFFVKAVTKNGVEVITAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7I6</accession>
    <accession>A0A3S5H500</accession>
    <name>E9B7I6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_020390</name>
        <name evidence="3" type="ORF">LdCL_020009300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857935.1">
        <property type="nucleotide sequence ID" value="XM_003857887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7I6"/>
    <dbReference type="GeneID" id="13390069"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0490"/>
    <dbReference type="OMA" id="FWCNVAR"/>
    <dbReference type="OrthoDB" id="273797at2759"/>
    <dbReference type="PhylomeDB" id="E9B7I6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110152" checksum="03CA68A7BFBD1FA3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8C6</accession>
    <accession>A0A3S5H5H4</accession>
    <name>E9B8C6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable eukaryotic initiation factor 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LDBPK_050360</name>
        <name evidence="18" type="ORF">LdCL_050008600</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858223.1">
        <property type="nucleotide sequence ID" value="XM_003858175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8C6"/>
    <dbReference type="GeneID" id="13391355"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0410"/>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="PhylomeDB" id="E9B8C6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001515">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003117">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="308"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU75941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ31499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="625" mass="66488" checksum="74EFA11FD1181A50" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAS2</accession>
    <accession>A0A3S7WRR1</accession>
    <name>E9BAS2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha/beta hydrolase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_110840</name>
        <name evidence="2" type="ORF">LdCL_110013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859060.1">
        <property type="nucleotide sequence ID" value="XM_003859012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAS2"/>
    <dbReference type="GeneID" id="13389538"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1040"/>
    <dbReference type="OMA" id="RANMATC"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="PhylomeDB" id="E9BAS2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22618" checksum="D185FC98D24061B4" modified="2011-04-05" version="1">MRGRLGVTEAQLSNPVLHRDRASRPRYNGPLCNGHVLTIRGAFRPPIDLRAPERETAPSYDGNPTCLDWWLPTDAEAADATADGDAAAMRVRALVIILPGLTGSLKEFYVRRMARRLLRANMATCVLNARGMADTPLERSQIFSALFTKDLPHIMQAHMTREKVQERLLRRIPSLQSSGHHKGAAPIIGVAFSLGGLILTNYVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAY1</accession>
    <accession>A0A3Q8I971</accession>
    <name>E9BAY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_120070</name>
        <name evidence="4" type="ORF">LdCL_120005700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859118.1">
        <property type="nucleotide sequence ID" value="XM_003859070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAY1"/>
    <dbReference type="GeneID" id="13390109"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0100"/>
    <dbReference type="OMA" id="QHPPSKC"/>
    <dbReference type="OrthoDB" id="267907at2759"/>
    <dbReference type="PhylomeDB" id="E9BAY1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730272" evidence="3">
        <location>
            <begin position="32"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="499"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="621" mass="71388" checksum="8F1081AC59B6F33B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BB66</accession>
    <accession>A0A3S7WS83</accession>
    <name>E9BB66_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_120840</name>
        <name evidence="2" type="ORF">LdCL_120020500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859203.1">
        <property type="nucleotide sequence ID" value="XM_003859155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BB66"/>
    <dbReference type="GeneID" id="13390138"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1640"/>
    <dbReference type="OMA" id="IHRAECH"/>
    <dbReference type="OrthoDB" id="271917at2759"/>
    <dbReference type="PhylomeDB" id="E9BB66"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48475" checksum="20E6509520BDC1F4" modified="2011-04-05" version="1">MLHLTSEPQKKKGPAVPECSRFLLGLALLLTIISDGAMNSQFTALSTIITANSDPSALQQLATFAAMEDVAEEEHLDWGSTARLVQAQPTSPAKPRNAVPPDPTTLGSVSAHAHSRTDSENMLSDGLSKSLTDISTNGVVGNSSAASSSSSRRRPHRRHHRRSGTVSDVPSKDDATAALSASRPVHSYHMWTQFHVMEMAYSTGSNNFVHITERFLEYQQMFPIVYCCDVNKVDCPYEAELLASPKVGLAASSRWSCENCGKRHNVVRESCLRCRAPGMYSKLFIGQAVKEVGCTESLVRFFYATHPDIVIHRAECHHDTDADALQRGKGCASIYVRREDAALLQQKLHRNAFFDVDSVTEQLLVYYVYAEQQQWLHSYAQQRNAGMRKRPLFLPLSPLVVEESASSSAPARRVTGHGQGRRRQSIPDSTSLPSERAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BC81</accession>
    <accession>A0A3S5H6U2</accession>
    <name>E9BC81_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_150400</name>
        <name evidence="2" type="ORF">LdCL_150008900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859565.1">
        <property type="nucleotide sequence ID" value="XM_003859517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BC81"/>
    <dbReference type="GeneID" id="13392917"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0500"/>
    <dbReference type="OMA" id="YSCDMEN"/>
    <dbReference type="OrthoDB" id="272876at2759"/>
    <dbReference type="PhylomeDB" id="E9BC81"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="654" mass="69226" checksum="180F5614924BDBC4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCX6</accession>
    <accession>A0A3Q8IAG7</accession>
    <name>E9BCX6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L39, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">60S_ribosomal_protein_L39_putative/GeneDB:LmjF.16.1170/GeneDB:LmjF.29.2370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_161220</name>
        <name evidence="9" type="ORF">LDBPK_292480</name>
        <name evidence="4" type="ORF">LdCL_160017400</name>
        <name evidence="5" type="ORF">LdCL_290030800</name>
        <name evidence="6" type="ORF">LDHU3_16.1490</name>
        <name evidence="7" type="ORF">LDHU3_29.3680</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="13" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="14" key="6">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 2-51</scope>
    </reference>
    <reference evidence="4 11" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859809.1">
        <property type="nucleotide sequence ID" value="XM_003859761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862666.1">
        <property type="nucleotide sequence ID" value="XM_003862618.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="l=1-51"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="o=1-51"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="l=2-51"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="E9BCX6"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="E9BCX6"/>
    <dbReference type="GeneID" id="13385369"/>
    <dbReference type="GeneID" id="13393147"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161220"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3680"/>
    <dbReference type="OMA" id="RRTKMNI"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5428982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="51" mass="6486" checksum="6E3038043A4AAC18" modified="2011-04-05" version="1">MGRFKPLAVKKKYAKKMNQNKPVPYWIRLRTGNRIKWNEKRRHWRRTKLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEL3</accession>
    <accession>A0A3S7WVW3</accession>
    <name>E9BEL3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_200660</name>
        <name evidence="2" type="ORF">LdCL_200011300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860406.1">
        <property type="nucleotide sequence ID" value="XM_003860358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEL3"/>
    <dbReference type="GeneID" id="13386193"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0800"/>
    <dbReference type="OMA" id="THIPRRH"/>
    <dbReference type="OrthoDB" id="273789at2759"/>
    <dbReference type="PhylomeDB" id="E9BEL3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="615" mass="63221" checksum="B48DF9D19F999B05" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>E9BF59</accession>
    <accession>A0A3S7WWE6</accession>
    <name>E9BF59_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_210740</name>
        <name evidence="9" type="ORF">LdCL_210012300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860591.1">
        <property type="nucleotide sequence ID" value="XM_003860543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BF59"/>
    <dbReference type="SMR" id="E9BF59"/>
    <dbReference type="GeneID" id="13386404"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0800"/>
    <dbReference type="OMA" id="ITDFYYL"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="PhylomeDB" id="E9BF59"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000017">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="430" mass="47389" checksum="0E5EA4D37A4C8459" modified="2011-04-05" version="1">MHAVHKDDARAPLLNTESRCRVALIDTSGYASDMNISAFVPQHAMKPYRVLAAMEIVRSLKIDAHCRTVVPPLVKVEELMAYHTDTYLANLGLHSCRSWLWNAETSKVFFSGDCPPVEGLMEHSIATASGTLMGAVLLNSGQVDVAVHWGGGMHHSKCGECSGFCYVNDIVLGILELLKCHDRVLYVDIDMHHGDGVDEAFCTSDRVFTLSLHKFGESFFPGTGHPRDVGYGRGRYYSMNLAVWDGITDFYYLGVFEHALHSIVRRYSPDVIVLQCGADSLAGDRLGLLNLSSFGHGQCVQAVRDLGIPMLALGGGGYTIRNVAKLWAYETSILTGHPLPPNTVLPVAEMPLSGWLFQDSPLLIVAQDRSNHVLPGLHCQRAYQMMTEQIDRHVPHIQPHPRLQKASTEAAAVDKQVEDGTTAVEDFKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BH47</accession>
    <accession>A0A3S7WYI8</accession>
    <name>E9BH47_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid transporter protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_241850</name>
        <name evidence="6" type="ORF">LdCL_240024100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861275.1">
        <property type="nucleotide sequence ID" value="XM_003861227.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13391197"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2260"/>
    <dbReference type="OMA" id="QDIWLEC"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="PhylomeDB" id="E9BH47"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1316" mass="144080" checksum="23DA4555174585E5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BL33</accession>
    <accession>A0A3S7X2P1</accession>
    <name>E9BL33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_292360</name>
        <name evidence="3" type="ORF">LdCL_290029700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862654.1">
        <property type="nucleotide sequence ID" value="XM_003862606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BL33"/>
    <dbReference type="GeneID" id="13385357"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3490"/>
    <dbReference type="OMA" id="DFCRHFF"/>
    <dbReference type="OrthoDB" id="250182at2759"/>
    <dbReference type="PhylomeDB" id="E9BL33"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="707" mass="76573" checksum="033B461DC8402F84" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLX8</accession>
    <accession>A0A3Q8IF13</accession>
    <name>E9BLX8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-finger protein, conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_302350</name>
        <name evidence="4" type="ORF">LdCL_300029000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862947.1">
        <property type="nucleotide sequence ID" value="XM_003862899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLX8"/>
    <dbReference type="GeneID" id="13385655"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3180"/>
    <dbReference type="OMA" id="HIRKRHK"/>
    <dbReference type="OrthoDB" id="267058at2759"/>
    <dbReference type="PhylomeDB" id="E9BLX8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF3">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1154" mass="122430" checksum="34F2C0806A8CECEB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E9BME2</accession>
    <accession>A0A3Q8IJS8</accession>
    <name>E9BME2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleolar protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_310200</name>
        <name evidence="12" type="ORF">LdCL_310007000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863110.1">
        <property type="nucleotide sequence ID" value="XM_003863062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BME2"/>
    <dbReference type="GeneID" id="13385832"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0240"/>
    <dbReference type="OMA" id="FTKYRHH"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="PhylomeDB" id="E9BME2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000609">
        <property type="entry name" value="Putative nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="252"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="344"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ36420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="628" mass="70215" checksum="2A220AE012444074" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQI6</accession>
    <accession>A0A3S7X7G1</accession>
    <name>E9BQI6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_340320</name>
        <name evidence="7" type="ORF">LdCL_340008300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864197.1">
        <property type="nucleotide sequence ID" value="XM_003864149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQI6"/>
    <dbReference type="GeneID" id="13392606"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0470"/>
    <dbReference type="OMA" id="IAHNCNS"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="PhylomeDB" id="E9BQI6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001734">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="762" mass="81257" checksum="1E42B007E9099544" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSN9</accession>
    <accession>A0A3Q8II95</accession>
    <name>E9BSN9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane transporter protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_353680</name>
        <name evidence="4" type="ORF">LdCL_350041800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864948.1">
        <property type="nucleotide sequence ID" value="XM_003864900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSN9"/>
    <dbReference type="GeneID" id="13387825"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350041800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4830"/>
    <dbReference type="OMA" id="GMMLSEW"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="PhylomeDB" id="E9BSN9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="620" mass="66807" checksum="A6E83B506283BE8E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSQ1</accession>
    <accession>A0A3S7X9N5</accession>
    <name>E9BSQ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cullin family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_353800</name>
        <name evidence="4" type="ORF">LdCL_350043000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864960.1">
        <property type="nucleotide sequence ID" value="XM_003864912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSQ1"/>
    <dbReference type="GeneID" id="13387837"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350043000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4960"/>
    <dbReference type="OMA" id="CAFGEDV"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="PhylomeDB" id="E9BSQ1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="488"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="875" mass="95409" checksum="A4187CB51B2911F8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSS5</accession>
    <accession>A0A3S7X9U1</accession>
    <name>E9BSS5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LDBPK_354050</name>
        <name evidence="15" type="ORF">LdCL_350045600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864983.1">
        <property type="nucleotide sequence ID" value="XM_003864935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13387861"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350045600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5260"/>
    <dbReference type="OMA" id="WKSMANG"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="PhylomeDB" id="E9BSS5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="647"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="545"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU83205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ38304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1343" mass="147064" checksum="AC0C7BD474F4D7D2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BTB4</accession>
    <accession>A0A3Q8IFS3</accession>
    <name>E9BTB4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_360550</name>
        <name evidence="1" type="ORF">LdCL_360010400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865171.1">
        <property type="nucleotide sequence ID" value="XM_003865123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BTB4"/>
    <dbReference type="GeneID" id="13388057"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0710"/>
    <dbReference type="OMA" id="DMFSIAN"/>
    <dbReference type="OrthoDB" id="258081at2759"/>
    <dbReference type="PhylomeDB" id="E9BTB4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="444" mass="49463" checksum="AC036F023AF5D80B" modified="2011-04-05" version="1">MENIKEEICLVANIIDRLLAANGSLRADELEPLTNRLRVAAGELSRIDQESQSGPVLSPFSRNIDDAEGIGGGGRRGPSKLQLSKSLTPLTATRKQIRGCRTFSATCKKMGDPKVFVSSEISQSVCCSLYNLLEGTTRLLRGSHGHIFVKRGVDMFSIANVSRKLAFPPPQVHHRCLGSADAEVLGSSIALNRNVDEVGRKSAVLIFPVHKLLPEGGPGEPIATIHVERREHVFFPFSESDEYTLYFASLFCGELMSRIPQINFLETFYDPSTQLIIAPFEPHCPVVLPPIERGMVPMRGETGKQASENPEYAARAVSQLSRKISARAPEILIHRESRPTHNTKPFAPGVTHMPSLLEIKAYVENLQSCWKKNMLDNVDLLELDRGTQQDLKVARSELAATRRELAATADRLRLYELDAWDYKREYGAMKSELDAYMDSLERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUR4</accession>
    <accession>A0A3S7XBY8</accession>
    <name>E9BUR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_365570</name>
        <name evidence="3" type="ORF">LdCL_360063000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865670.1">
        <property type="nucleotide sequence ID" value="XM_003865622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUR4"/>
    <dbReference type="GeneID" id="13388556"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360063000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7400"/>
    <dbReference type="OMA" id="TERYKAT"/>
    <dbReference type="OrthoDB" id="248410at2759"/>
    <dbReference type="PhylomeDB" id="E9BUR4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="592"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="863" mass="97940" checksum="9A11095AC79164CC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-08-02" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JGM1</accession>
    <accession>E9BS90</accession>
    <name>Q4JGM1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <ecNumber evidence="8">3.5.4.2</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Adenine_aminohydrolase/GeneDB:LmjF.35.2160</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH</name>
        <name evidence="12" type="ORF">CGC20_15595</name>
        <name evidence="11" type="ORF">CGC21_6610</name>
        <name evidence="10" type="ORF">LDBPK_352200</name>
        <name evidence="8" type="ORF">LdCL_350026900</name>
        <name evidence="9" type="ORF">LDHU3_35.2810</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2005-06" db="EMBL/GenBank/DDBJ databases">
            <title>Leishmania donovani adenine aminohydrolase.</title>
            <authorList>
                <person name="Zarella-Boitz J.M."/>
                <person name="Hartman C.U."/>
                <person name="Ullman B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1S2D</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="8"/>
    <dbReference type="EMBL" id="DQ093583">
        <property type="protein sequence ID" value="AAY98748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP48105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864799.1">
        <property type="nucleotide sequence ID" value="XM_003864751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4JGM1"/>
    <dbReference type="SMR" id="Q4JGM1"/>
    <dbReference type="GeneID" id="13387677"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2810"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAY98748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP44489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP48105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="362" mass="40859" checksum="8852A6B5CF2D0652" modified="2005-08-02" version="1">MADATLLHRLIEALPKAELHVHIEGTLSPELLFELAKRNGVQIPYKTVEEVRAAYNFTDLQSFLDLYYEGMSVLITEDDFADLAYAYTRVMHESRVTHAEPFFDPQGHLCRGITFRVLYDGLMKGFRRGEAEFGVSVALIFSFLRHLSEEECFALVRDDMHPDNGQYIRELFAAKAFVAVGLDSSELDNPPEKFARLYRYCHEELKVPFLVAHAGEEGPPGYMRDAMSMLAVDRIDHGVAARLDQALCKDLREKRIPLTVCPTSNVALKVFQDRATCGAVVMDLVLTEGLCITINSDDPAYFGGDIRESFRILAETGRLTPATLKQLVLNSFCSSFIAEDRKRAYEERVEKVFKDVCGGTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8T5</accession>
    <name>A0A3Q8I8T5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endonuclease G, putative</fullName>
            <ecNumber evidence="7">3.1.30.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_100013400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8T5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0990"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="6">
        <location>
            <begin position="116"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="5">
        <location>
            <begin position="117"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="507" mass="54155" checksum="0912A9203574868C" modified="2019-04-10" version="1">MSASAAIARLLGAASLALFGVTAYWAYSTQASKRTQLVVQPGRSLVTTANATPSIVSAGSDSSSQGSVRGDAALAFPVVLPPHTPPAQASTLTADFLQQCNEAAAHGLPSTAEVRCYGGYLASLNYERRIPNWVMEVVDYRKLHSGRRPSSPAAAAANRDDDAAQAADDEGSDGSRGGGDVSRNRSNFYADDTVPAAFRVGPNSYTSRGMSRGHLAAAQLHKASQAEMDATFNMNANIVPQDMTLNAVDWLRLEGLTRKLSKEVSVGLQQQQPGRVRQRGDSPPAGNTAKAEDAGSSGKLYVVTGPAFVPRLMRVEHRSDGTEVHVPLSSADANAAPWKSAAPVKLMMTYELTGHPARGTPVAVPSHLFKVFLAEENGGRSHSVAAFMMPNGPIIEELPLTAYQVPIERLQRITGLQFFPGMDATRLPDLCKTHKCDARPSALFQRYRQVAQLRAADSVPQLRQTYAALQASAAGGKLDEAVVHEFQNRMEELVAAAVGLIDQAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I908</accession>
    <name>A0A3Q8I908_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_110013500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I908"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1010"/>
    <dbReference type="OrthoDB" id="272072at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052603">
        <property type="entry name" value="EFCB6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20875:SF0">
        <property type="entry name" value="GH12158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="903"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="976" mass="104446" checksum="56756611E34EE8D4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I949</accession>
    <accession>E9BAY2</accession>
    <name>A0A3Q8I949_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_120075</name>
        <name evidence="2" type="ORF">LdCL_120005800</name>
        <name evidence="3" type="ORF">LDHU3_12.0110</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812632">
        <property type="protein sequence ID" value="CAC5428248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859119.1">
        <property type="nucleotide sequence ID" value="XM_003859071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I949"/>
    <dbReference type="GeneID" id="13390110"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120075"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120075.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0110"/>
    <dbReference type="OMA" id="ACCFADP"/>
    <dbReference type="OrthoDB" id="264109at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10038" checksum="3DAA15A4A12BA066" modified="2019-04-10" version="1">MDLCGTDVVPFQGVRLGTTPTEDFYLTTLEKKLLRMSAMEQLRACCFADPPLPTARDGGEQSLLWCVLSESVRVFLSLMLFLCLVAHLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBB3</accession>
    <accession>E9BGV9</accession>
    <name>A0A3Q8IBB3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Archaic Translocase of outer membrane 14 kDa subunit, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Archaic_Translocase_of_outer_membrane_14_kDa_subu nit_putative/GeneDB:LmjF.24.0940</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_11875</name>
        <name evidence="5" type="ORF">CGC21_16100</name>
        <name evidence="3" type="ORF">LDBPK_240960</name>
        <name evidence="1" type="ORF">LdCL_240014600</name>
        <name evidence="2" type="ORF">LDHU3_24.1130</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861187.1">
        <property type="nucleotide sequence ID" value="XM_003861139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBB3"/>
    <dbReference type="GeneID" id="13390872"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1130"/>
    <dbReference type="OMA" id="VKQVVWM"/>
    <dbReference type="OrthoDB" id="270989at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="115" mass="13304" checksum="904779E11A646CE0" modified="2019-04-10" version="1">MSAFMEKYHINKALGTTLRAVQSVWDWTRERLWPIYSAAVVISLFQMIAVASEKQILADHYYGDVDGKFEEHKDELVRDAKKLFNEEVAVAVKEHVWQLSPAAFRREYSSRLGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBC4</accession>
    <name>A0A3Q8IBC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/thr protein phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220021800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBC4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2080"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000085">
        <property type="entry name" value="Putative ser/thr protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF12">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="339"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="811" mass="85663" checksum="B27E3E5210A2E39B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICD9</accession>
    <name>A0A3Q8ICD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase, putative</fullName>
            <ecNumber evidence="6">3.4.11.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase family, catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_30870</name>
        <name evidence="8" type="ORF">CGC21_0930</name>
        <name evidence="6" type="ORF">LdCL_110011700</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICD9"/>
    <dbReference type="SMR" id="A0A3Q8ICD9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0830"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF49">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="140"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP39845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="284" mass="30334" checksum="08B56AB42DFE0C6E" modified="2019-04-10" version="1">MTVLKGEELREKGYGGIYAVGKCAQYPPHLVTLRYRNPNAAEGAKNIAMVGKGIVYDCGGLALKPAAHMTNMKTDMGGSAGVFCAFIAVVRSMKMQRTHFSHIANISVTLCLAENAIGPHSYRNDDVVVMKSGKSVEVMNTDAEGRIVLGDGVCYATGEQDFVPDVLIDMATLTGAQGVATGSKHAGVYASDAEAEKDMINAGLRSGDLCYPVLYCPEYHEEVYKSPCADMRNTANSPSSAGSSCGGYFVEQHLSERFRGPFVHVDMAYPSSNMTAADVVMMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICK5</accession>
    <name>A0A3Q8ICK5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230019200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICK5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1590"/>
    <dbReference type="OrthoDB" id="268016at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10890" checksum="AD3430B6ECD79D89" modified="2019-04-10" version="1">MGSFCAKPDAAPKDDVHEGEKNYQEEGEKSFNDANVEATSKPQQCDKDDAAKDVEAADDAAKCAEVEDMEEKQEKFEVDPKNESDDMERQADEKREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID13</accession>
    <name>A0A3Q8ID13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_240026400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2520"/>
    <dbReference type="OrthoDB" id="273050at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37425" checksum="370F9A81C1ACC94A" modified="2019-04-10" version="1">MGYGGPRVEFYTANQYSNFAAAIDRENAARVRSIVHRRKLPGEQEAQRQREEAFRAYERARADEVARVHAEEAEALERRLATKTCRRSLTAAEVASRRSRHACLCRLAEPRKYQEAMYGSGMIGGAMPHQRGRDGKLPTVGRNGAVYCAGVDRDRIVPSRPALEGTVPPWRGSYSTHHGPHKLDAQMAKEAAAYYCAHPAPQRSASQQDMRQKTLQSIAAEHSMEAQQDGADVGMADASGEKGRSSAADAEQRHRMGSDNVDDETGSIFSHGSSNGPIVATGNMHLSTTSTKNSVQLHLSRYGGAMTAPRPRRPSKAASENLTLPELADRLVCIQMSKSVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID95</accession>
    <name>A0A3Q8ID95_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250017200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID95"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1500"/>
    <dbReference type="OrthoDB" id="273589at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="56810" checksum="AA8311543AAE6F09" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDD4</accession>
    <accession>E9BHQ8</accession>
    <name>A0A3Q8IDD4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain cysteine protease family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Calpain family cysteine protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_8815</name>
        <name evidence="6" type="ORF">LDBPK_251540</name>
        <name evidence="5" type="ORF">LdCL_250021100</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861484.1">
        <property type="nucleotide sequence ID" value="XM_003861436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDD4"/>
    <dbReference type="GeneID" id="13388730"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1910"/>
    <dbReference type="OMA" id="DCYYLCA"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000105">
        <property type="entry name" value="Calpain family cysteine protease-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000323">
        <property type="entry name" value="Calpain family cysteine protease-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="165"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="706" mass="80468" checksum="4B3B3921DE738E3F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDK8</accession>
    <accession>E9BJH2</accession>
    <name>A0A3Q8IDK8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Protein_kinase_putative/GeneDB:LmjF.27.2470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_32115</name>
        <name evidence="10" type="ORF">CGC21_18565</name>
        <name evidence="8" type="ORF">LDBPK_272420</name>
        <name evidence="6" type="ORF">LdCL_270032600</name>
        <name evidence="7" type="ORF">LDHU3_27.3650</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000015">
        <property type="protein sequence ID" value="TPP53945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862093.1">
        <property type="nucleotide sequence ID" value="XM_003862045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDK8"/>
    <dbReference type="GeneID" id="13386828"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270032600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3650"/>
    <dbReference type="OMA" id="IQNVHEY"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000651">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP45940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="560" mass="62800" checksum="A77F7D6CCC7650AA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDL2</accession>
    <name>A0A3Q8IDL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal-dependent decarboxylase conserved domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_160009200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDL2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0510"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="568" mass="59791" checksum="DBE13344B6A53261" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDV4</accession>
    <accession>E9BIE4</accession>
    <name>A0A3Q8IDV4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA ligase OB-like domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">DNA ligase k alpha, putative</fullName>
            <ecNumber evidence="8">6.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_31995</name>
        <name evidence="9" type="ORF">LDBPK_261320</name>
        <name evidence="8" type="ORF">LdCL_260018800</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861719.1">
        <property type="nucleotide sequence ID" value="XM_003861671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDV4"/>
    <dbReference type="GeneID" id="13388965"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1630"/>
    <dbReference type="OMA" id="FECCDDA"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000375">
        <property type="entry name" value="DNA ligase k alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="382"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="630" mass="67832" checksum="421E74BA0A85D2BD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE55</accession>
    <accession>E9BDK3</accession>
    <name>A0A3Q8IE55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA-binding protein 29, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_3410</name>
        <name evidence="5" type="ORF">LDBPK_180220</name>
        <name evidence="4" type="ORF">LdCL_180007100</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860036.1">
        <property type="nucleotide sequence ID" value="XM_003859988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE55"/>
    <dbReference type="GeneID" id="13393479"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0260"/>
    <dbReference type="OMA" id="FCQCGTI"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000851">
        <property type="entry name" value="RNA-binding protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="409" mass="43476" checksum="F30764EF4F0F09D3" modified="2019-04-10" version="1">MSGTPMQTRFGCYIGNIDRSVTIDMLKQVFCQCGTIIDCSLNGREGDPYRFGFIDFATEDDRARAMKYNGFTLVGRKLKVGVSKGNVNKPEGYATGNGAGGGHSRMGGNRHYNNDGGMMMSVNGLSPQQQMEARLLLQFLQEGKMDPRQLSPAQQQLLITCLGHGNSGNAVNGSSTNSDSSTPASAQQLQMGVMGSSAMQSSLPLPTMHNSGNMMGDAAAFMPNPNTGNAAPGAGVPMMGGGAPQGIHINMGPSMMDPMSGGYGMMPPRQPQPQQWGDMPINGPGMYPPKMCGPPLRQQPQVPMQAGQQQPYGLGGGAASISGPGAADQNRGGFINPPPAAETLKLREKQREQFFEVVRKDAEKYERKLQEKKAQSTAGGDAERSADSSASDDDEDKKPAKRSKKESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEV6</accession>
    <name>A0A3Q8IEV6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330021800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEV6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2280"/>
    <dbReference type="OrthoDB" id="273646at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="583" mass="63501" checksum="64040A1CB0B07AE3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEY8</accession>
    <name>A0A3Q8IEY8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme/AMP-binding enzyme C-terminal domain/Ankyrin repeat/Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280027000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEY8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2970"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000085">
        <property type="entry name" value="AMP-binding_enzyme/AMP-binding_enzyme_C-terminal_ domain/Ankyrin_repeats_(3_copies)/Ankyrin_repeat/Ankyrin_re peats_(Many_copies)_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="863"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1003" mass="108966" checksum="B66BE108956C880E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGH5</accession>
    <name>A0A3Q8IGH5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Thioredoxin/Thioredoxin-like, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Thioredoxin/Thioredoxin-like_putative/Pfam:PF0008 5/Pfam:PF13905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_26885</name>
        <name evidence="5" type="ORF">CGC21_8440</name>
        <name evidence="3" type="ORF">LdCL_250012500</name>
        <name evidence="4" type="ORF">LDHU3_25.0900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGH5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0900"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="154" mass="17602" checksum="FE80F1A068542606" modified="2019-04-10" version="1">MAIRVISTLAELQVLTRQPKLTVVDFFATWCGPCKVIAPLLENLASRKQHVNFAKVDVDRTPDVIRDYPVRAMPTFYFFRDGNVVATFEGADINSVTQLVQQHEVIPPPAIPSDKELDAMKPRDLLSLMRQHHISTTGLMEKSELIEEIRKYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGM2</accession>
    <accession>E9BSV2</accession>
    <name>A0A3Q8IGM2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_354320</name>
        <name evidence="7" type="ORF">LdCL_350048300</name>
        <name evidence="8" type="ORF">LDHU3_35.5730</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865010.1">
        <property type="nucleotide sequence ID" value="XM_003864962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGM2"/>
    <dbReference type="GeneID" id="13387888"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350048300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5730"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000615">
        <property type="entry name" value="Ubiquinone biosynthesis O-methyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="321" mass="35058" checksum="728C018A813422EB" modified="2019-04-10" version="1">MKGVAADEVAKFASLQKHWWDPTGPLRSLHLLNPIRVRYVNNIVRSFGNVGGSSCDTSIGFSRDSGLTPQHQVLDVGCGGGILAESLARIGGTVTGIDACAESIEVAEKRRQQLEANFIASSQAFNWPQRLSYRHVSLFDVVEQEKRQFDVVVASEVIEHVSDARAFLQALCEATKPGGLLFLSTMDKSLKTAIAYIGVAEMLTGLVEPGTHDWRKFIPPDDVTKFAQRFGVRKVDQHYIVTYPDVCQSFVSCNFQVNFCLSKHVNTGHYLWAGRKSSPEAGMQASVPPGEGCVPHAPECNENEFSLQPRGNGSADATESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGR1</accession>
    <name>A0A3Q8IGR1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_320020800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGR1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1910"/>
    <dbReference type="OrthoDB" id="275848at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="161" mass="18876" checksum="2FEB7BB5FC48D513" modified="2019-04-10" version="1">MKWLSRLMLRKKRTPLPPKPYVDTASTGRHMLDARLYDSDDLAQIDPEKPHWQDMRFESRERVPFFDVFGYNRDWSWSLFKVSSLFFVMIFYWEMRSFAYMKNDPIKITSTTTVSPVPDYARDEKATEEELREAGFAYVGLEKLDNLGISAASSCEANHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH44</accession>
    <accession>E9BNZ9</accession>
    <name>A0A3Q8IH44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EamA-like transporter family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">EamA-like_transporter_family_putative/Pfam:PF0089 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_322480</name>
        <name evidence="2" type="ORF">LdCL_320030100</name>
        <name evidence="3" type="ORF">LDHU3_32.3070</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863661.1">
        <property type="nucleotide sequence ID" value="XM_003863613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH44"/>
    <dbReference type="GeneID" id="13390949"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3070"/>
    <dbReference type="OMA" id="QWMFFAV"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14692" checksum="4912F6596C318FA3" modified="2019-04-10" version="1">MFLVNASVAGACGALSGVVGKLAVESARVPSLVRSGGLYLQLDLATMEMVQAVVPWLLRIFFFLMNAILTGSMWRFYLKALSQGPTPVCQILNTGTNFVVSALAGLVFFEEEVTPMWGAGALLIVLGLALVVSDPQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH62</accession>
    <name>A0A3Q8IH62_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290013600</name>
        <name evidence="3" type="ORF">LDHU3_29.1190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH62"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1190"/>
    <dbReference type="OrthoDB" id="271018at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="391" mass="43281" checksum="5004BE47C8BF5C74" modified="2019-04-10" version="1">MSCERIDPKDFHSPAANQYTLNCLDELARSPKFKSYVRHVEYKERFYLTWFLAPFTLFGILYYHLKMFGEEGVSLFMGSPTSSFASLPAPPAGMVCATVILLLFAVPCIVIAPFAGFFEEPRRWQSLITLAFLTLVNIAVVSFGGSPLHYPPFVTTMPPVTELIVSWNPVDVAAILVRDIFVRRALCLQGFLLAGYTVAFWRSRFWDRVWHPPLPLVTVPIAVGLSGIGWWVVVQKGVPLFFTADGCPTLVAEALYWSAVKSDPAGAASLCFTVGKEIYRQVVRDAASLWQQRQLPMVLQNPSACMSLYLATASMALVHVFVLLVKPVADFVFGVFFFVLPTDPTLWGLTLIGTIGGAVTLWRMNDGLVYTPHIAGLCAVAFSLLLNGFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHG2</accession>
    <name>A0A3Q8IHG2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340022100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHG2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2410"/>
    <dbReference type="OrthoDB" id="264277at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1001" mass="106334" checksum="650E41920695437E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHJ6</accession>
    <accession>E9BQB7</accession>
    <name>A0A3Q8IHJ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deaminase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">OTT_1508-like deaminase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">OTT_1508-like_deaminase_putative/Pfam:PF14441</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_10530</name>
        <name evidence="4" type="ORF">CGC21_37705</name>
        <name evidence="3" type="ORF">LDBPK_331860</name>
        <name evidence="1" type="ORF">LdCL_330025400</name>
        <name evidence="2" type="ORF">LDHU3_33.2750</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864012.1">
        <property type="nucleotide sequence ID" value="XM_003863964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHJ6"/>
    <dbReference type="GeneID" id="13392407"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2750"/>
    <dbReference type="OMA" id="HNYLQCH"/>
    <dbReference type="OrthoDB" id="278553at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5433389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP55512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="271" mass="29271" checksum="377946678C2481FB" modified="2019-04-10" version="1">MPFDRYDLAGTANINELVLRHGTMKTSDLKTTRHPALYQRVGRPHDCSSSPFMLDRYLSNLVRALVHPLHNYLQCHHSLHNADEVQVMLMPKDGPIALADRAAVPSCSSSSHGGSGALRRCYVATNNETLTQESLQAAVADWGVAGVFQIGEFVLVTGEKGCHAEKKLLEHLKTQVLSHAAPPVLPTADQKALIVGERLPCVACRLFAIAFESVAVLLPSHGHLYLSTIAAGVETHAAAKSGKTKDINAMFASPAEAAALLLAPKHRRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II89</accession>
    <name>A0A3Q8II89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340012000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1070"/>
    <dbReference type="OrthoDB" id="266612at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1658"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1698"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1888"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2074"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2183"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2242"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="899"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1501"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1741"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1934"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2046"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2147"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2295"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2358"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2368"/>
            <end position="2385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2393" mass="251434" checksum="3FD73DCEADB66D45" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIK6</accession>
    <name>A0A3Q8IIK6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150007200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIK6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0320"/>
    <dbReference type="OrthoDB" id="10261083at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="55768" checksum="3D17BE3DE3EF287D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ99</accession>
    <name>A0A3Q8IJ99_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_360068700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ99"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360068700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8090"/>
    <dbReference type="OrthoDB" id="272564at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="795" mass="86249" checksum="88518D6488F02E2E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJJ1</accession>
    <name>A0A3Q8IJJ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360041400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJJ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360041400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4720"/>
    <dbReference type="OrthoDB" id="267962at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18088" checksum="325E99C5B5700AD2" modified="2019-04-10" version="1">MEEDRASGQRLAERDASDPSELPGGVQRVAPASAPTSSFANIQMRPEGQRYGHADLVPGGSLSGNGGMLMNERNFRGPGMPCVPLRGPGEGQPDLGSADGYARFDPIFPGQMPPGRGRGRFDVGGSWGQGAPNLPGEPDNDLFLPPQGGPGEPFGGPGGGQFGPRHSWGGNSPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK49</accession>
    <accession>E9BTR4</accession>
    <name>A0A3Q8IK49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein MSH6, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Mismatch repair protein MSH8, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">MutS domain V family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_13320</name>
        <name evidence="8" type="ORF">LDBPK_362050</name>
        <name evidence="7" type="ORF">LdCL_360026000</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865320.1">
        <property type="nucleotide sequence ID" value="XM_003865272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK49"/>
    <dbReference type="GeneID" id="13388206"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360026000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2670"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000014">
        <property type="entry name" value="Mismatch repair protein MSH8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003151">
        <property type="entry name" value="Mismatch repair protein MSH8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000068">
        <property type="entry name" value="Putative mismatch repair protein MSH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111198" checksum="F5889EB3CA0B6DA4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL89</accession>
    <name>A0A3Q8IL89_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_360070300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360070300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8340"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="744"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1354"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1525"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1354"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1373"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1543"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2337" mass="260152" checksum="179388E11C40AFC5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILB8</accession>
    <name>A0A3Q8ILB8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320032100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILB8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320032100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3300"/>
    <dbReference type="OrthoDB" id="238279at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="162" mass="19163" checksum="280D3FC3D17473D4" modified="2019-04-10" version="1">MAGAPPVSFVHTATRTLLHDIRTFTHWDPAANKLQCAIRDAAYLVIDLPRFFMYSHSNYGAMRRYIRQSRINKGKVNPEDFKDVDTNVLRESLIKYAQAKGPLQKIDFRWFYWVYAIMIIYVGWQGMYLQSLLDARVDRMGASLEQRRDMYDDDYLEEVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILQ1</accession>
    <accession>E9BUV3</accession>
    <name>A0A3Q8ILQ1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_365960</name>
        <name evidence="3" type="ORF">LdCL_360067000</name>
        <name evidence="4" type="ORF">LDHU3_36.7880</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865708.1">
        <property type="nucleotide sequence ID" value="XM_003865660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILQ1"/>
    <dbReference type="SMR" id="A0A3Q8ILQ1"/>
    <dbReference type="GeneID" id="13388595"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360067000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7880"/>
    <dbReference type="OMA" id="MYRLAWS"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5435175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ39032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="265" mass="30127" checksum="0453B49852A1ECA2" modified="2019-04-10" version="1">MGFLTVYKGGEPPKSNVAQEAFDYIYEQIPAPVEVDVERFLEIGHFESLATATCLSLEDLSLYLLAFAVDESAKRIYRISEKHFVAWMAGLISKLPRNAAPPTRENAYAPLFAAAHGAIVDLNNTIRNNEDKRSKFYQFLYNWCLKGNDASDRVDSAKELWSCFFSASPVSFTAEEARRKFTAYVCFPRINQWLDFITILGEKATESKSARAAVEQSGVSFDTWTQLLLFAQFDNYDAYDDEDSWPVTMDDFVEYVRKLEASKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPX1</accession>
    <accession>E9BJ53</accession>
    <name>A0A3Q8IPX1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_271210</name>
        <name evidence="1" type="ORF">LdCL_270018600</name>
        <name evidence="2" type="ORF">LDHU3_27.1880</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861974.1">
        <property type="nucleotide sequence ID" value="XM_003861926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPX1"/>
    <dbReference type="GeneID" id="13389236"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1880"/>
    <dbReference type="OMA" id="NAFHYAH"/>
    <dbReference type="OrthoDB" id="270509at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17915" checksum="002B723D87048B62" modified="2019-04-10" version="1">MTHGALNAVSGFLSTISSRSAQSRRTHRPCIPYVLVAMTHHLPEMDILFGGAVTPSALTMNDEGGKFVAQRGSVQILVDAFHYAHCMETSKERAEEAKQKRCSAARCCQRAPGLDHWRSRPFSAATLKSGVVTRFSRCAARVRIRCRLPRSRQTSTPTDAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISW8</accession>
    <name>A0A3Q8ISW8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_310038200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISW8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310038200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5160"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="580"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1090"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1204"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1240" mass="134335" checksum="3CB2E4490ECB1DD3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITN7</accession>
    <name>A0A3Q8ITN7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger of a C2HC-type, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_320042400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITN7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320042400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4610"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF68">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="558" mass="58132" checksum="5E04389C25482924" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IU86</accession>
    <accession>E9BPM3</accession>
    <name>A0A3Q8IU86_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Complex 1 protein (LYR family) protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Complex 1 protein (LYR family), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_37235</name>
        <name evidence="2" type="ORF">LDBPK_332850</name>
        <name evidence="1" type="ORF">LdCL_330035600</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864109.1">
        <property type="nucleotide sequence ID" value="XM_003864061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IU86"/>
    <dbReference type="GeneID" id="13392505"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330035600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3990"/>
    <dbReference type="OMA" id="FLQLIYH"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="166" mass="18968" checksum="E1F64A4FB7A257D6" modified="2019-04-10" version="1">MLRGGLQTSPRLMARGIAGPQVLGAEVPSFRSFPYRAQDTLYLYRHFLQLIYHHYGPEERKDLLFRLRNEFSSKRHLRGPRAVSAALKRGEGMLALQRQLLQSREVRRGTSRDGGAQSVDTLWDQFQMVSGNVLPGLRNYEKSLPVSSGSYVTQASTNNVYSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVD9</accession>
    <accession>E9BSK1</accession>
    <name>A0A3Q8IVD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase associated with various cellular activities (AAA) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Replication factor C, subunit 3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Replication_factor_C_subunit_3_putative/GeneDB:Lm jF.35.3250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_15085</name>
        <name evidence="10" type="ORF">LDBPK_353300</name>
        <name evidence="8" type="ORF">LdCL_350038000</name>
        <name evidence="9" type="ORF">LDHU3_35.4350</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP48003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864910.1">
        <property type="nucleotide sequence ID" value="XM_003864862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVD9"/>
    <dbReference type="SMR" id="A0A3Q8IVD9"/>
    <dbReference type="GeneID" id="13387787"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350038000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4350"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP48003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="364" mass="39746" checksum="0E169FFFB38C3DFC" modified="2019-04-10" version="1">MYAGRQGEEAKAAASHLPWVEKYRPSTLESVVAHEDILSTLRHLMDSGNMPHLLLYGPPGTGKTTTIKACAYYLYGKDRVRANVLEMNASDDRGIDVVRQQTREFASTSSIFSMMGSGSSTGGGSGGPAAKFKLVILDEADQMSHDAQAALRRVIEKYTRNVRFCILCNHINKIIPALQSRCTRFRFAPVKKSAMMPRLRFVAEQEGVKYTTDGLAAAFRLSHGDLRRCLNTMQASALSANEVTEESVYRVTGNPTPADVTAIVSDMLSSDFATSWIKVEESVVQKGISIADLTREIHPVMMAMDLPQDCKCFLLMKLSDLEYYAAGGARESAGLGGLLGAFQLVKEAVTQRKPIKDVAGECAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IWC9</accession>
    <accession>E9BUL9</accession>
    <name>A0A3Q8IWC9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_14835</name>
        <name evidence="4" type="ORF">LDBPK_365110</name>
        <name evidence="3" type="ORF">LdCL_360058300</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865625.1">
        <property type="nucleotide sequence ID" value="XM_003865577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IWC9"/>
    <dbReference type="GeneID" id="13388511"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360058300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6830"/>
    <dbReference type="OMA" id="HNCIEDE"/>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF29">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="313" mass="34213" checksum="22296ECE6306472C" modified="2019-04-10" version="1">METCDGVDGVAGAPKMTESLILQQCRTHQGYSTPELNEKLYLHHLGFTQLDGLAAFTGCVVLYLDHNALSDLAGLAALTRLDSLYLSCNALSHLDSMPRLPLLRTLDVAQNQIVTLNGLDEAAPQLQTLLAGRNKLQSLDGVQGLSGLLSLDVSHNCIEDEEATSACLCGNRATLRTLLLHGNELCRRTPHHRKRWIAAFPALRFLDEYPVFDDERARAEAFAGGGAAAEAEIRSAQRTRALAEAREQFAYYGDIREAQRAARLRNGAETQATPYFLAHTPSINKTVLQDAEDEPIYIPATRGAAVHQDPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Y4</accession>
    <accession>E9B7F8</accession>
    <name>A0A3S5H4Y4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc-finger of C2H2 type family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Zinc-finger of C2H2 type, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Zinc-finger_of_C2H2_type_putative/Pfam:PF12874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_37255</name>
        <name evidence="13" type="ORF">CGC21_29850</name>
        <name evidence="12" type="ORF">LDBPK_020110</name>
        <name evidence="10" type="ORF">LdCL_020006300</name>
        <name evidence="11" type="ORF">LDHU3_02.0190</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5426973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000040">
        <property type="protein sequence ID" value="TPP43072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000062">
        <property type="protein sequence ID" value="TPP43999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857907.1">
        <property type="nucleotide sequence ID" value="XM_003857859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4Y4"/>
    <dbReference type="GeneID" id="13390041"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0190"/>
    <dbReference type="OMA" id="PFIRIVS"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000007">
        <property type="entry name" value="Zinc-finger of C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5426973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ31181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP43072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP43999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="239" mass="26943" checksum="909660035DB29157" modified="2019-04-10" version="1">MTSGPNSVTNIYDPIEVARANPYFKRNHMGQVTCTLCGIYCPEENNFLKHIAGKTHALQLQRRQHKELRHLRLQEEERLNTEAEERARKEEALLALSGGQTGNGAAGGAGALSSAAAAAANARFGTPLYSFRTEHDEVAYRTKVWIEVMFTQAEEGTRPLHRWLSAREQHVEKPADDYFVYLLFACEGYATIALKFPAKANRSQPRDVLEEADGSTSEAYWCSWDPLQKVYTLFFVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H502</accession>
    <accession>E9B7I9</accession>
    <name>A0A3S5H502_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Voltage-dependent anion-selective channel, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Voltage-dependent_anion-selective_channel_putativ e/GeneDB:LmjF.02.0450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_37125</name>
        <name evidence="4" type="ORF">CGC21_30005</name>
        <name evidence="3" type="ORF">LDBPK_020420</name>
        <name evidence="1" type="ORF">LdCL_020009700</name>
        <name evidence="2" type="ORF">LDHU3_02.0530</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5427004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000040">
        <property type="protein sequence ID" value="TPP43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000062">
        <property type="protein sequence ID" value="TPP43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857937.1">
        <property type="nucleotide sequence ID" value="XM_003857889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H502"/>
    <dbReference type="GeneID" id="13390072"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0530"/>
    <dbReference type="OMA" id="KFQPCVA"/>
    <dbReference type="OrthoDB" id="270618at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000040">
        <property type="entry name" value="Voltage-dependent anion-selective channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="277" mass="30113" checksum="EE44D2C01DEE3E0C" modified="2019-04-10" version="1">MTTLFKDYNKGTTDLLTKNFSSCGEWKVESKGKAPRGAYALTTTSNTHGSVNVDIEGLTDSGAYYGKLTFASRDLTDVKVTVRAEDFDNHRVEAIIGHKGPALCDISVEVNHQTMRPIAGGRLSINDKFTQKAVELALSMATVDGVQVGCGTKYDLKSQTIDWTAACRLEAKNGLVLTAQTNRLLDLTASMVSKAPLHPKFQPCVAATMTMNPQSMTWDGSMAVEWGCQVILGNTAKVRVNKNLDWIASYIANLRGGWTLVLSIDKTMKAGLTLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F7</accession>
    <accession>E9B899</accession>
    <name>A0A3S5H5F7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Nudix hydrolase 2, putative</fullName>
            <ecNumber evidence="2">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_9295</name>
        <name evidence="3" type="ORF">LDBPK_050090</name>
        <name evidence="2" type="ORF">LdCL_050005800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858196.1">
        <property type="nucleotide sequence ID" value="XM_003858148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F7"/>
    <dbReference type="GeneID" id="13391039"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0120"/>
    <dbReference type="OMA" id="FLGCQRM"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000112">
        <property type="entry name" value="NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="179" mass="20269" checksum="624BE9A9AA727429" modified="2019-04-10" version="1">MYRPNVCVFLFNEKVEFLGCQRMKTDHFQCVQGGIEACDVDIRLAALREVEEEIGLKPQDLIFVQEIPPPNGDPMKFAYTLASNANLRRFGYVGQKQRILLFFTPSENISKVVLIPPPELHASQEFRKVEWMPIEQLIAKSLPEKVHIFKAVGEVAPGIARAFLKKRGLLAEPQGAAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5G3</accession>
    <name>A0A3S5H5G3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_050006700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5G3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0220"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000015">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU75923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="477" mass="50045" checksum="897ACD7AB2312098" modified="2019-04-10" version="1">MRAASCMAHRCIGAAAGAVTVARAPGWPYTASQRHFFATACALLGRSIPYKLADIGEGITEVQVLGVRVKAGDTINEFDPICEVQSDKATVDITSRYTGVVKAVYLQPGATAKVGSVMLDIVPEGADDAPEAASPSRGAPSSSSASHSALQAAYSAPQPSSVPSAGKVLATPATRYLAREHKLDLAHVPATGKGGRVTKEDVLQFMDASMSAAAAPSTPSTASVAATAPPGTVVSGVQTEAGDTVMPITGVRRGMVKTMSQAASIPTFTFSEECELTRLMAVRGSLKDMVKDRSKGKAKLSFMPFFLKAASIALQHHPDINAHCPADCSALVRKAAHNIGFAMDTPNGLIVPVVKHVERKSILDIANDMQVLIERGKSNKLTTQDMTGGTFTLSNIGVIGATVTAPVLLPPQVAIGAIGRLQKLPRFDANGSLYAANLICVSFTADHRVIDGASMVRFANTYKRLLEHPENMLVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H665</accession>
    <name>A0A3S5H665_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_080012200</name>
        <name evidence="4" type="ORF">LdCL_080012600</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H665"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0990"/>
    <dbReference type="OrthoDB" id="244479at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22601" checksum="2E12761F4D0A4989" modified="2019-04-10" version="1">MACKLGVIIYVVLQFIAFFSVLIGTGVDMFYIKPEHSFGIRVCITLWGGKTDCRKANVTISSDTRWKFCPIRRNNFRIGQAFAVISIFVYGAAFLFGFLLLYCCAGFRWLCLALNIVGAVTACVVWAVMVVTYRLPEPKCLELSDGYDFGTGFGLFVLAWILDIIDVIFLMLPWQIGESGKGDEPNVQEEEEEVGSKKATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6E8</accession>
    <name>A0A3S5H6E8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090020800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6E8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1690"/>
    <dbReference type="OrthoDB" id="273701at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28607" checksum="80571959A79BA463" modified="2019-04-10" version="1">MMMPMTGSRNSPVRPSGVVRHAHETDKPVIENCAQSNPLLDAPPDPPHKAGKRSVVSCAPSGTSSAARASDVAALLRHAVVRDLIRENEGMLMEIAGLQETKRLWCATQLRLVTLEESAARAALKAAESIARGVWATRAHASLAAHVQRLEQQLSDEAEEAAELRGFAELAQAQLATSPRLQTEGATPEKEKYASPPAKGRRGSGMGDVDGNSQRASLEEITNVRGSVKRLRSVESSDSSGTPRGQARRTSSSQKSPGALTKVCKTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H792</accession>
    <accession>E9BEZ2</accession>
    <name>A0A3S5H792_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAR domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">BAR domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">BAR_domain_containing_protein_putative/Pfam:PF031 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_22835</name>
        <name evidence="5" type="ORF">CGC21_33750</name>
        <name evidence="4" type="ORF">LDBPK_210070</name>
        <name evidence="2" type="ORF">LdCL_210005600</name>
        <name evidence="3" type="ORF">LDHU3_21.0080</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860524.1">
        <property type="nucleotide sequence ID" value="XM_003860476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H792"/>
    <dbReference type="GeneID" id="13386337"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0080"/>
    <dbReference type="OMA" id="CDEDYNR"/>
    <dbReference type="OrthoDB" id="262066at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="245" mass="28060" checksum="DCE18464481C8945" modified="2019-04-10" version="1">METMMKIKTALKLAPSTCDEDYNRRKREMKDLCSAIRSYNTAMEKAKVSVRRLVEALTEASKVFETLCNYPNIPDCTKDCALALVASMNRIEGTAFPEFNVAMDSTVLTATNGLKALYDECERLECKRNKVMHEYDTYREEVSKKETEYLRKSKSLLKSKYYSTEVARRDELEAAFDSADQKFKDTHDQLMQSRSVTCTDALNAFVSCMSRFMEEISGELEGLKGSSEYVLPILRNIMRAEHESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ09</accession>
    <name>A0A3S7WQ09_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070016700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ09"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1400"/>
    <dbReference type="OrthoDB" id="265718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="374" mass="40113" checksum="023E1823C8A62ED2" modified="2019-05-08" version="1">MRSTAAATPTAAQAARILSLKQKLQALPTEQDHYRRHYEEPEGVCWDVLDDLAENEGRCAHDSTGIGPPSAEDGAPLLDASSSPPSRLASLATAPRASAGRHGLGYPVSASHDGPHSHPSLCSDATPAGVSSRRATQRHLSDHPPPSRRTTISSSRPDPRLRCSGEADVLSPQETQLLLRRLRRLHQWMGDLVTGVSAATSSGCADVGCRGDGALRDPSATATEVIANVCPCSDSSAACSAFPLSARESPLKRVTALRLHRVVDDLFMLFTQLQATLTDVVWCTSHPPALSTPVRTHLAHDVEVERLRAINQQLRRTLRGYEQSHQTASEAPAPRPYDSIKAPRRAAPPLSSPPPPAGYAASHESGLFIALRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRL3</accession>
    <accession>E9BAP6</accession>
    <name>A0A3S7WRL3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat (TPR) protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Tetratricopeptide_repeat_(TPR)_protein/GeneDB:Lmj F.11.0490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_30800</name>
        <name evidence="10" type="ORF">CGC21_0995</name>
        <name evidence="8" type="ORF">LDBPK_110580</name>
        <name evidence="6" type="ORF">LdCL_110010500</name>
        <name evidence="7" type="ORF">LDHU3_11.0630</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859034.1">
        <property type="nucleotide sequence ID" value="XM_003858986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRL3"/>
    <dbReference type="SMR" id="A0A3S7WRL3"/>
    <dbReference type="GeneID" id="13389838"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0630"/>
    <dbReference type="OMA" id="ANYHAMA"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF18">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="407" mass="44953" checksum="985F07FA13C2F325" modified="2019-05-08" version="1">MPPKGLFKSAAKAQRAKAKKERQLLEARMRECYEKCAEARGYLEPTGRSAEPNFTKAKTALDAAIEAYDASSLAFFLLGQWNRMQGMYKEAIECYSHALDLEPTNVQALEWRANCFQTLHDYLHAIEDNTSIISLDPENDHAYNMRGLCVLQSSVPGLRLRSVHFESCVRDFSAAVRLNEANYYAMANLGKAYEVQGHLEKAIECYGKALDSSEGYAYARFRRGCTALHMAERSILRREESEGSSDSDAPEASADAAKAVHGSSTQHMTEAASSTISRVPGGATTLKEVKAEVRQQIEEEEEAQKAAKLLKLADGDFTMLLDRSPEAKILTADATVVLNIGICALLSKNINRAEEHLKLAQEIVAKRPGLVEEGEAPPLENMDTFNSVLAIRLNELQKLKDMARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRP9</accession>
    <name>A0A3S7WRP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_110014400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRP9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1110"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1004" mass="105736" checksum="2CB393DAB66B5DE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSB2</accession>
    <name>A0A3S7WSB2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cis-prenyltransferase-like protein</fullName>
            <ecNumber evidence="5">2.5.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_130005200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSB2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0040"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008834">
        <property type="term" value="F:ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000019">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="391" mass="43982" checksum="99442CC87FEC8880" modified="2019-05-08" version="1">MLTGTLPQLQHGTTPAQRGASSALNDSHDILALRTACGKFGVVCFSLLVFAFLGHIALALLKLSSRGGVPRTSKAITVNKLHHIAHSVRHLGIIMDGNRRYGRRHSTAARCPDPSALREIREELCSATELTATHSATEQSCWLAARYKRFASVIQHSSLDGHRVGGEKLLEVIKHSMEAGIDMVTVYAFSTDNWNRPAAEVDALMSLFFFFFDRIRKEALERHIFVRFISTELFRLPPRAVEFMRSVERETRAVQPRRLVLNICVSYSGQSEVVAACNRLVARRLRDSTDPASAAAVATEVTKKELDREMLRSITQDEHEAEDAHLFGGDVSVEPELILRTSGEQRISNFLLYECAYSEFVFLDKAWPEVTQEDIRQALSDFTRREKRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSP4</accession>
    <name>A0A3S7WSP4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130018550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSP4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130018550"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17770" checksum="269995BCF418B5D1" modified="2019-05-08" version="1">MSSSAADELQPMNGRDNYLPHISSPSRRRSSIPSANQPSKYGDMRHPQQQQSQVLSHVPPQLRNPSEGSNSNNVGYAQASAVRGTGAMSGTVAQGASLSGASLLNNDTGKTAAALSLYPYDGRPTKPAREAWEKAEVGRAGPRAVPSNIKALGTGAPTTQQRRHPQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTZ9</accession>
    <accession>E9BCU2</accession>
    <name>A0A3S7WTZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleolar protein, Nop52 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Nucleolar protein,Nop52, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_24920</name>
        <name evidence="8" type="ORF">LDBPK_160890</name>
        <name evidence="7" type="ORF">LdCL_160014200</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859775.1">
        <property type="nucleotide sequence ID" value="XM_003859727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTZ9"/>
    <dbReference type="GeneID" id="13393190"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1060"/>
    <dbReference type="OMA" id="AWCDLEL"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP51152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="662" mass="74614" checksum="EC7D636BA937CF1C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUB3</accession>
    <name>A0A3S7WUB3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170009100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0630"/>
    <dbReference type="OrthoDB" id="266986at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1378" mass="141127" checksum="EB67ACFA78854D54" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV40</accession>
    <accession>E9BDQ4</accession>
    <name>A0A3S7WV40_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Elongation factor Tu GTP binding domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Elongation factor Tu, mitochondrial, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Elongation factor Tu, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Elongation_factor_Tu_mitochondrial_putative/GeneD B:LmjF.18.0740</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_39375</name>
        <name evidence="15" type="ORF">CGC21_3180</name>
        <name evidence="14" type="ORF">LDBPK_180740</name>
        <name evidence="12" type="ORF">LdCL_180012500</name>
        <name evidence="13" type="ORF">LDHU3_18.0990</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860087.1">
        <property type="nucleotide sequence ID" value="XM_003860039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV40"/>
    <dbReference type="SMR" id="A0A3S7WV40"/>
    <dbReference type="GeneID" id="13385945"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0990"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF22">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5429290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP53259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP55274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="466" mass="51523" checksum="8F45D2F116271CCB" modified="2019-05-08" version="1">MFRSCVHRLAPKAKEAFVRGKPHLIIGTIGHVDHGKTTLTSAITTVLAKRGQAQALDYFAIDKSPEEKSRKITINATHVEYESEKRHYGHIDCPGHMDFVKNMITGAAQMDGGIIVVAATDGVMPQTREHLLICSQIGLPALVGFINKVDMTDEDTCDLVDMELREQLEKYKFPAEETPIVRGSALKAVEGDAKYEENILELVRKCDEWIPDPPRNTDKPFLMAIEHVYEIGKDKKSVVVTGRVDQGILKLNTDAELAGFSSKKSTVRVTGIEMYHKTLSECMPGDSVGVSIVGTGDTTSLSKGNVERGMVMAATGSTNLYNKVKAQVYVLTKDEGGRHTGFSPHYRPQLFFHCADVTADMSFPEAEKHREELNKKFGRGPEEDKKKEAAMKEFESKLVCMPGDNRELILTLAYPMPIEKGLKFTIREGKITVGWGAVVETMGLDTKVNIEGKRIGAKPVTGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV66</accession>
    <name>A0A3S7WV66_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BTB/POZ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_180020700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV66"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1950"/>
    <dbReference type="OrthoDB" id="265657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="419" mass="44313" checksum="FD39F6E15559CC82" modified="2019-05-08" version="1">MAAPDTSVSRTADTASDVDNGDDVVAFVVGDGQHKLYFSKRALMRHAPFFRAYFTEHAAEVAAASGGGSGATTVVLRHVKPRSAEAALRLCHSAHHSDDGLFWLLQRECEKADEAHKPEALQAVLSLYAACVKFELYEHAKAASATAAGAVTAHTVYDVLKTCARYATTLLPETRRAVGLDVLLAACYAFMRTSGAWQGERRWRRLYEQYPELSEIVAAASAATATSSAHGESSASAAAGGSPSPLRRVLLSPQKDPATAGSSATVMPESAAPLPDVFAGHLRQTEGLALAAQWRCRTMSAEVTALRESCAALEVTAHRDEAAAAEVALYLGEVRVYVQALGCAEAEMQQLCAAAATMCAAPSSSAAAASTLHELRHALQRASAWAAERKAAVDELLAMEQDAVCELDAELARLRAVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXL6</accession>
    <accession>E9BGA5</accession>
    <name>A0A3S7WXL6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_17275</name>
        <name evidence="10" type="ORF">LDBPK_230860</name>
        <name evidence="9" type="ORF">LdCL_230015200</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.176" evidence="1"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860986.1">
        <property type="nucleotide sequence ID" value="XM_003860938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXL6"/>
    <dbReference type="GeneID" id="13389947"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1160"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="309"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="441" mass="47351" checksum="18317D35DDD7759D" modified="2019-05-08" version="1">MFRSSLTHRQAAPRVFIVGGHITPFVGKGSKLFIDKKHPDFGKKQNMTLEEILATTVQHTIGNTGLNGKEDIVDQVVVGNFLGELFSSQGHLGPAAIGSLTYGQAAAKNPLMYKPAMRVEGACASGGLAVISATNALKAGSADIALAVGVEVQTTATARVGGDYLARAADYQRQRKLDDFTFPCLFAKRMKYIAEHNHFTMEDTARVAAKAYANGNRNPLAHMHTRKLSFEQCNGEDPSNVKFLGNETYKEYLRMTDCSQVSDGGAGVVLANEEGLKKMGLSPNDSRLVEIKSIACAVSNLYEDPDDACCMFTSRQAAQKALSMANVKPSDLNVAEVHDCFTIAEMLMYEALGIAEYGHAKDLIRNGETTLEGRIPVNTGGGLLSFGHPVGATGIKQVMEVYRQMKGQCGAYQMKKIPALGATLNMGGDDKTAVSAVLQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY35</accession>
    <name>A0A3S7WY35_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_240005000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY35"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0030"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000007">
        <property type="entry name" value="Pyruvate dehydrogenase (Lipoamide) kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000205">
        <property type="entry name" value="Pyruvate dehydrogenase (Lipoamide) kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF40">
        <property type="entry name" value="PROTEIN-SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019341166" description="Protein-serine/threonine kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="134"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="483" mass="55168" checksum="690A82FE72B811D9" modified="2019-05-08" version="1">MSRPCLLLLGIDVVFAHVSGSCINHVGRADLVMLRRGFCRSIPLLGPTFTELVERLDSFEKEFIEWKAFRKAVESTSPKVTEAAKEIIAESMKEVKTSKVNLENPLTPEEFTELNQFYAKQKVKDIFFENLLYINTPNDLMQHSETVFRQYLVRIARRVRHLNHAPYGLSQMPGIQMLKKWYQWSFHDVRSTPVPTTRDECYRCDRMVRRVFLRHYNVSSLITDGMVEFASREGWTHVDEEVMRTYDELQNFFEAFCLGRVRLRFLVGNYMYLSTKILGVSKEEYAVNDRDGLTVPIFFDHNAEDFVGQICKKCSLLVLTKCAIKEAQASYDAEIELKLAGDPNLVFVGIPYITYDIICAMLEDAVSANVDRQERTGKACTKIEVTLAQWPTNKRFVLRISDTAGGMTLRQASKQLSCWSLYRNIQGHNQDTISTWTSSPIRLPYAYNAARVIGGNITLASIEGYGTDRQLYLPSTGLAGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYU5</accession>
    <name>A0A3S7WYU5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_250010500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYU5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0650"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000261">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001797">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000355">
        <property type="entry name" value="Putative ATP-binding cassette protein subfamily B,member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="76"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="394"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="656" mass="71728" checksum="D9A55F2A0D60C27E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ91</accession>
    <accession>E9BHT3</accession>
    <name>A0A3S7WZ91_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC21_8920</name>
        <name evidence="15" type="ORF">LDBPK_251790</name>
        <name evidence="13" type="ORF">LdCL_250023600</name>
        <name evidence="14" type="ORF">LDHU3_25.2230</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861509.1">
        <property type="nucleotide sequence ID" value="XM_003861461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ91"/>
    <dbReference type="GeneID" id="13388755"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2230"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600666" description="Pyruvate dehydrogenase E1 component subunit beta" evidence="11">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5430755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP40786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="350" mass="37880" checksum="1E2BF72E959C7883" modified="2019-05-08" version="1">MRRFASRALFSASAAMAARCATTNMTVRDAIHSALDEELAREEKVFVIGEEVGQYQGAYKVTKGLVDKYGKDRIIDMPITEHGFAGMAVGAALSGLRPVCEFMTFNFAMQAIDQIVNSAGKSLYMSGGQMKCPIVFRGPNGASAGVGAQHSQCFGPWYASVPGLKVIAPYNCEDARGMIKAAIRDDNAVVVLEHELLYSESFPVTDEVADKNFVIPFGKAKIEREGKDITLIGFSRGVDLCLKAAEKLAAEGVQAEVINLRSLRPLDRHTILSSIKKTHRAVTVDESFPVCNIGAEICACVMESDTFDYLDAPIERVSCADCPTPYSKDIEMASQPQVADVMAAAKRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZA4</accession>
    <name>A0A3S7WZA4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_250024600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZA4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2330"/>
    <dbReference type="OrthoDB" id="275551at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="282" mass="32674" checksum="5DD21141C190FDDB" modified="2019-05-08" version="1">MRGSGDDIFRAPESGEKDLVDKIKNRRKKLELYQSESHKMKSLMMNSAGVRSDLVTGNGMALNPIWATFPTRCVKPITSVEEMREKLDYFSKTDDVMVVRYHQNNCTACNAVDKVFEMLCHQAATRTPGLKFYDVNRNDVPDLTKGLVRFPQIKGYSGGQWADIDFKPPTAFREELYAAIEEEVKRLKNEGKPVTALQAEEMYFSGAGPAMLEVTEEQLMKFYCKAQVRLHNYWRQVSMRRTWFYRKFIEPEVEERVMDEWRARSVFGEKVVYGPQPSDEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0F9</accession>
    <name>A0A3S7X0F9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_31205</name>
        <name evidence="2" type="ORF">LdCL_270010200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0F9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0700"/>
    <dbReference type="OrthoDB" id="244442at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="594" mass="64992" checksum="7EB0681E144C170E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1N8</accession>
    <name>A0A3S7X1N8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280023400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1N8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2440"/>
    <dbReference type="OrthoDB" id="266423at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="62018" checksum="1A47A48446371ECC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1P5</accession>
    <accession>E9BJU5</accession>
    <name>A0A3S7X1P5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein family (UPF0220), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Uncharacterized_protein_family_(UPF0220)_putative /Pfam:PF05255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_13010</name>
        <name evidence="11" type="ORF">CGC21_22565</name>
        <name evidence="9" type="ORF">LDBPK_282240</name>
        <name evidence="7" type="ORF">LdCL_280027500</name>
        <name evidence="8" type="ORF">LDHU3_28.3030</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862323.1">
        <property type="nucleotide sequence ID" value="XM_003862275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1P5"/>
    <dbReference type="GeneID" id="13387059"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3030"/>
    <dbReference type="OMA" id="NFLMWLP"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5431607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP40417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP54354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="142" mass="15531" checksum="8CAE2527D3C3654E" modified="2019-05-08" version="1">MSRRRSTIIIASGGVFGCALLVFMDGAVMASKAKLPYNFLMWLPTLVALLGTFVLSLVKPVYILGTDSDLDDDDDGIKKAKSMFFVGALLLFTSICLSIWKTVDPYGNKGVAWPGAALLVHSLLLMLMNYALFIARAQYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X266</accession>
    <accession>E9BKL3</accession>
    <name>A0A3S7X266_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scavenger mRNA decapping enzyme C-term binding family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Scavenger mRNA decapping enzyme C-term binding/HIT domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_27855</name>
        <name evidence="3" type="ORF">LDBPK_290670</name>
        <name evidence="2" type="ORF">LdCL_290011400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862484.1">
        <property type="nucleotide sequence ID" value="XM_003862436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X266"/>
    <dbReference type="GeneID" id="13387223"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0940"/>
    <dbReference type="OMA" id="KSHIQSC"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000004">
        <property type="entry name" value="aprataxin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="1">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="264" mass="29146" checksum="90E86EAA34893D1F" modified="2019-05-08" version="1">MQASPVLAGAAVRRTAAASVGSEPRTRLPFLINVVKKAQKSANTVVAPTPALSSTLSTTEPPIQAAAFKPYPLLSPGETKQAAGSSLLYKDDVCVLVNDAFPKSMVHCLVMPLDLRLQSLNALTKKDIPLLRHMLHVGDEYVRYLKTVVPHTYTARRFIAGFHALPSLPMLHLHVLSTDLDSPCLKNKKHYNSFATFFFLTGYRVLEDLEQHGRVTLNQDVTRLRQMEEQDMKCLWCGTALPSVPAMKSHIQSCPQNKAVEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2H6</accession>
    <accession>E9BKW9</accession>
    <name>A0A3S7X2H6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_28375</name>
        <name evidence="2" type="ORF">LDBPK_291710</name>
        <name evidence="1" type="ORF">LdCL_290022700</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862590.1">
        <property type="nucleotide sequence ID" value="XM_003862542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2H6"/>
    <dbReference type="GeneID" id="13387326"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2460"/>
    <dbReference type="OMA" id="VELWCGS"/>
    <dbReference type="OrthoDB" id="270836at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP52800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="122" mass="13308" checksum="F3A0FA7A5BFE352B" modified="2019-05-08" version="1">MRGTNDTPTANSGGKLQIRTALLESVRRYNEDCLNTSTAAAAEEPLATPTQRGDRFPDALPRMIAQLYPSLTNPSWAMEECVRLCPAAEVWCGTALPKDVWAPPGTAECPFGTEPMDFNAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2I2</accession>
    <name>A0A3S7X2I2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290023500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2I2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2570"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000516">
        <property type="entry name" value="Thioredoxin_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="357"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="451" mass="46638" checksum="C9234B3B2A5451C5" modified="2019-05-08" version="1">MYTGAFSMFAAWAAVGAHRGNWRTRVANSWVAAPSNDLRTPSSVCLISYPQAERTTSTDIGRRGGAVLGATAPDIEGPRYRQRSLSVQRLLSPTEAPSPLRVKTTLTEQRMTAVASSVAATAAAASLATRMRVCAALDAAAKSDETPADTGSAPSFDCASQHTKDGAPAAASPDDSAAFTEMAGQKQSSPAADHTCDSPPLPPSGTEPLAATPPAPVFSFHGNPQELQDRLRGAKALVFFYKASCAPCAVIRSKLLHAVAGAGGGGSGATAAPPTSAEHATEAAGVDGLPSPLLDYLQQNQREPDSPTGVSAAAPIAAYAEAKDAKAAGATTASLPATTMTLEDQKSCDVACRFLGDATKSFAHSVILITVDTNANAEVTALHDIRSLPTFMAYRNGCIVGRFEGSQEDEINKLVDLLAENSTERSPTTDNRTPSPLPQQEGATSKRVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2K3</accession>
    <accession>E9BL00</accession>
    <name>A0A3S7X2K3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_25100</name>
        <name evidence="5" type="ORF">CGC21_28525</name>
        <name evidence="3" type="ORF">LDBPK_292030</name>
        <name evidence="2" type="ORF">LdCL_290026200</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862621.1">
        <property type="nucleotide sequence ID" value="XM_003862573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2K3"/>
    <dbReference type="GeneID" id="13385324"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2900"/>
    <dbReference type="OMA" id="CPQRIPK"/>
    <dbReference type="OrthoDB" id="273211at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="459" mass="49540" checksum="5297F6561F696492" modified="2019-05-08" version="1">MSPVAAQQFKSNALFRVLAFLDNTGAQAFALDAEVDEAGSFRNPESVFAADAAITGVLTAALDALRANVRRLFTDAAEQHALLAVLGTGAPEQSKKASLWITATPAPLPLEEGGTAPAGLSSDEALQQQESSSIPLSSAPVSTAWSEAVLHPTSLAHYADDVENEIPIHLLVRLREVLGIPAAPLCCCNCSPFVEQFLIDGLDEWLRRCRVDEVKRMILACGVQPTVLNSTFMRQQQAADAQDAALPDALADFVVDVVFPVPAHAGKVSANASSAAAAEALQDWLILSFEKNHEAVDIDDENASANGQSGSSDNSGTNSQGERKRTRTDDTRPSADNRDGLGSWEPAKGEEVLTAENIDRYLLECPRRIPKEILREKRKRISDASITEFELDHHYTAAELKKLVKEGLGAMTASEATDFMECPVTEAQVQQAARMTRKAQFVAWILSVHKAAVQQQSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Q3</accession>
    <accession>E9BL11</accession>
    <name>A0A3S7X2Q3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-AMP-activated protein kinase catalytic subunit alpha, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_28565</name>
        <name evidence="10" type="ORF">LDBPK_292140</name>
        <name evidence="9" type="ORF">LdCL_290027400</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862632.1">
        <property type="nucleotide sequence ID" value="XM_003862584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Q3"/>
    <dbReference type="SMR" id="A0A3S7X2Q3"/>
    <dbReference type="GeneID" id="13385335"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3050"/>
    <dbReference type="OMA" id="FEMEWKV"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000929">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP52838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="815" mass="88322" checksum="D92FC1BEE460C066" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X374</accession>
    <name>A0A3S7X374_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin conjugation factor E4 B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_300015900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X374"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1390"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114587" checksum="05813C6A72C8D3F4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3B4</accession>
    <name>A0A3S7X3B4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WW domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_300016700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3B4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1480"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000034">
        <property type="entry name" value="syntaxin-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="996" mass="104623" checksum="438E95D8833B387B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4G0</accession>
    <name>A0A3S7X4G0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310022400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4G0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2660"/>
    <dbReference type="OrthoDB" id="273231at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1148" mass="120187" checksum="1E8D8D37C5A51379" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4I0</accession>
    <name>A0A3S7X4I0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pentamidine resistance protein 1</fullName>
            <ecNumber evidence="13">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_310021500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="13"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2360"/>
    <dbReference type="OrthoDB" id="272196at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1356"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="295"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="704"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1498"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1759"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1768"/>
            <end position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1806" mass="193640" checksum="5A57C01F271B12D8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4Q4</accession>
    <name>A0A3S7X4Q4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310030200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4Q4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3930"/>
    <dbReference type="OrthoDB" id="265030at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="825" mass="88339" checksum="DF15804EB7F90661" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5X6</accession>
    <name>A0A3S7X5X6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine nucleotide exchange factor in Golgi transport N-terminal/Sec7 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320034800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320034800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3660"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000019">
        <property type="entry name" value="Guanine_nucleotide_exchange_factor_in_Golgi_transport_N-terminal/Sec7_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF391">
        <property type="entry name" value="SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1523" mass="166143" checksum="3CA8B87B7B248D3E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6U9</accession>
    <name>A0A3S7X6U9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitogen-activated protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_330028900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6U9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3170"/>
    <dbReference type="OrthoDB" id="272152at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000966">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="864"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109971" checksum="033FECD5E95BAE95" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6Z1</accession>
    <name>A0A3S7X6Z1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diphthamide synthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_330032500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6Z1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330032500"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="667" mass="71176" checksum="F342B69D8D25A613" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8M8</accession>
    <accession>E9BRP8</accession>
    <name>A0A3S7X8M8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_0855</name>
        <name evidence="3" type="ORF">CGC21_5700</name>
        <name evidence="2" type="ORF">LDBPK_350160</name>
        <name evidence="1" type="ORF">LdCL_350006600</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864609.1">
        <property type="nucleotide sequence ID" value="XM_003864561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8M8"/>
    <dbReference type="GeneID" id="13387487"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0230"/>
    <dbReference type="OMA" id="QSHNAMS"/>
    <dbReference type="OrthoDB" id="239978at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="315" mass="34747" checksum="AAF3089CB469CEAD" modified="2019-05-08" version="1">MSYRRKAPASKTLTPSQQLGKLCNARSGNLVFQSHNAIALLAQLHKLDRAYYDQFAKNATVQRFVPAWAVRTSQEGGTPTRYTLPLPSHFINTGESADDFEPRAFFLEKALSADMGIDGKVPAFPRCGRSGLFFAREEVVDNLQAAAADLKFSSPFWLHKNHPGLESGYLQLKEGNEAIVISLTASIIGLGDVETVEAAKLYPLLRKEIKSDVNSASGFSVSDEIPLGMNALTGAVTKNPFVCSLPNRGLWLSQDQLLHHNIRLSRRITQAARAFTLVEIDQWELFNADQLQVPGRLGLRQSLNLAPNETVFQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X983</accession>
    <accession>E9BS66</accession>
    <name>A0A3S7X983_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_6485</name>
        <name evidence="4" type="ORF">LDBPK_351930</name>
        <name evidence="2" type="ORF">LdCL_350024500</name>
        <name evidence="3" type="ORF">LDHU3_35.2530</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864775.1">
        <property type="nucleotide sequence ID" value="XM_003864727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X983"/>
    <dbReference type="GeneID" id="13387654"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2530"/>
    <dbReference type="OMA" id="RMHQTPK"/>
    <dbReference type="OrthoDB" id="278352at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="619" mass="66506" checksum="BD36EA8392E119AF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAB2</accession>
    <name>A0A3S7XAB2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360010800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAB2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0750"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000109">
        <property type="entry name" value="Ubiquitin-like protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000402">
        <property type="entry name" value="Ubiquitin-like protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="317" mass="33119" checksum="CB024D9769475439" modified="2019-05-08" version="1">MAVTIKLANGSQHTVEVPDFSVTVAEFKKQIAEMLEIPASEQRIIMRGKVLKDDAVLSAIGMEDGSVIHVVRSKKSGASASSTNASSTLAASDPTSSPNVQPSTTTPAQPVPAQTAANPYAALMSNFGAPQTQQPVPGAAGFPAAGNPFAGMGMGMGMGGGMGGAVNPTPQQAMELMQNPMMQQMMQQALSNPQFMQYIIQNSPQLAGLQQDQQQAIIEMMRNPYMMQQAMAMMGSLGGTGGAPLATAQAPSTPAVGGGFNPAMFAPPVPQGNPREVYREQLQLLRDMGFPNEEANIAALQQAQGNVQFALERLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAB8</accession>
    <accession>E9BT37</accession>
    <name>A0A3S7XAB8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">50S ribosome-binding GTPase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">GTP-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GTP-binding_protein_putative/GeneDB:LmjF.35.5210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_14180</name>
        <name evidence="8" type="ORF">CGC21_8035</name>
        <name evidence="7" type="ORF">LDBPK_355180</name>
        <name evidence="5" type="ORF">LdCL_350057600</name>
        <name evidence="6" type="ORF">LDHU3_35.6910</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865095.1">
        <property type="nucleotide sequence ID" value="XM_003865047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAB8"/>
    <dbReference type="GeneID" id="13387973"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350057600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6910"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001924">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="464" mass="51534" checksum="60E7E108398F8A93" modified="2019-05-08" version="1">MRVTVRQCNVFDPAFMRKVKRTLSAYKESMETSAKKSMSREAFVDIDEKGAAWYLGHMHSAANMLADKVKDADFILEIRDARLPFTTENPNIRKLTAGKPRLIIFNKAELSNEDSNRAIQEYYERNGAFALFTSARRCWRDVVEAVQRFTTHILPPLPYKTVAHVGLVVGMPNVGKSTLINSLRLAHEYQFHREDFRRSRSPETVSITPGTTRGMKLVPLSKDPPVVLYDTPGLTLPGCFTKESGLKLAACGIIPTNDVSLPQGMVARYIYDILVASGSSEHMAECLHLPRMPISFDDCVAMICERSGTSGQTEMGNLDPVRAHRFFVHDFTMGNLGKITLDVLPRRVLRSAQSSTPLLEGGSSTAATDGAQAAAGDDDGYVWTHHVETSDVVERYPDHMRDVLQSLKGPLHHDGVPRRRGTPSVKSVNSPSDCTVISRKKGPISRATAFDEQLKRHTRLAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAQ6</accession>
    <name>A0A3S7XAQ6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_360023600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAQ6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2370"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="133"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="446"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="816"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="893"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="951" mass="102957" checksum="E54D8F954F5A8AF1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAT7</accession>
    <name>A0A3S7XAT7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">T-lymphocyte triggering factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_360025500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAT7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2600"/>
    <dbReference type="OrthoDB" id="767661at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039308">
        <property type="entry name" value="GAS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025593">
        <property type="entry name" value="GAS8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13851">
        <property type="entry name" value="GAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Growth arrest-specific protein 8" evidence="13">
        <location>
            <begin position="223"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="67"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="270"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="459" mass="53977" checksum="E0D57249936E98E7" modified="2019-05-08" version="1">MPPKTATAAAGGQQREKGKKDGAAAADPVKELRNMEDIHEVLAKAQQLRNYFQAERDKVNGMWDITKKELENEQFSLQNAESELEELEREHQVEMKVYQQKVRHLLYDQKVAVKQLRDESDAALRQAEAAHTQRMHQLEVERQRRMTGMQSAREAQESRIVDQRDGHQYMLTVTKRRNHEKELARLQAAYEAKLSTLREDLELRRRAEVQDAEERYNLHINHLIQQHEDKFNEMKAYYNHITHNNLEIIQSLKDEIATMKKNDEHNEGLMFEIEKENENLVAPLEQLEKEVAELQVKKQQHIQDKQSLRSFRTRYKLLQQQLCALRQEKEMLEDQYKNVYDEREDLRAKFESALREAMDVVADRNNSLQQNLIEAHARLEQRDAQLEGVLRAMGLEPAAMELISNEIDAEVQAKNQVIKDLHFEMRRLEKKVNAMVEEYERRCRAVGVPPLDRASVMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJW4</accession>
    <name>A0A451EJW4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040007100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJW4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0200"/>
    <dbReference type="OrthoDB" id="264685at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019318607" description="Surface antigen-like protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="53453" checksum="41E25C096C005312" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7V1</accession>
    <accession>A0A451EJT2</accession>
    <name>E9B7V1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_013370</name>
        <name evidence="1" type="ORF">LdCL_030013400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858048.1">
        <property type="nucleotide sequence ID" value="XM_003858000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7V1"/>
    <dbReference type="GeneID" id="13390423"/>
    <dbReference type="KEGG" id="ldo:LDBPK_013370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_013370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0910"/>
    <dbReference type="OMA" id="QEMWHAV"/>
    <dbReference type="OrthoDB" id="275730at2759"/>
    <dbReference type="PhylomeDB" id="E9B7V1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="395" mass="45115" checksum="84057A987F6B84E6" modified="2011-04-05" version="1">MWQRIRLLQTLASQKAAATAAAGAASSSPSAAAAAAPPSVAADNERSFLRNLIPMRVYSSGPPSIYLRHAFLNQDRLIRRFLGALETVPLPSLPRMLLAEGFQRMLEGDVPQRELRELFEDAEVECRKMLLHMDVSKGGHRRYHDSHADPRDQETWHAVRHDPLRRLLAHELRAACSHYARLMAVSSSPYVPAAVIVRTIIASDVRTDNFLVKMTLAFERHPRNVETGERVGEAMPPVVEELMKELLLLERDAFGCFRFDPRGDNHHLVHSLKLADMTKTPRSFSIMRDPLMKRYGNYRVECEEVHKGRWNQYKVHCGPEDHRIDPALPLFESVVATDPITGGALNMLVHYDEPICLRHKHSSREEKGNFGHTEVFELAMDVTNRTFWERYFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9B815</accession>
    <accession>A0A3S7WNQ9</accession>
    <name>E9B815_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_040500</name>
        <name evidence="3" type="ORF">LdCL_040010500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858112.1">
        <property type="nucleotide sequence ID" value="XM_003858064.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13390723"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0660"/>
    <dbReference type="OMA" id="NAALWFW"/>
    <dbReference type="OrthoDB" id="267932at2759"/>
    <dbReference type="PhylomeDB" id="E9B815"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1526"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1580" mass="165497" checksum="7B980E0B1FB996D3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9R2</accession>
    <accession>A0A3S7WQM1</accession>
    <name>E9B9R2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_090260</name>
        <name evidence="2" type="ORF">LdCL_090008300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858705.1">
        <property type="nucleotide sequence ID" value="XM_003858657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9R2"/>
    <dbReference type="SMR" id="E9B9R2"/>
    <dbReference type="GeneID" id="13392068"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0430"/>
    <dbReference type="OMA" id="WDRCMLA"/>
    <dbReference type="OrthoDB" id="273663at2759"/>
    <dbReference type="PhylomeDB" id="E9B9R2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25020" checksum="E338E66BB71833EB" modified="2011-04-05" version="1">MTLVFEARRLPFGSISEAYAAPIQPIVALHALDELPLWDRCMLVAVLPVVQQRHSAGAAAAPPSTVAQPPLTGSSGDNADAAAAASWSSATIRAANHEERVNASPELAGAPSLEDVTLALTIVRALDELEVVYDSSISTRAELEQQQQQPSLHAASLAEAPRRAFKQPKKTSEELLMEQLLQERLADTAPYLLESSDEDGEKSAEAAVDVAMCFTVKGESLGIGTANIFGGHGYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCC0</accession>
    <accession>A0A3S7WTF8</accession>
    <name>E9BCC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette protein subfamily A, member 7, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette subfamily A, member 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_150800</name>
        <name evidence="12" type="ORF">LdCL_150013400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859604.1">
        <property type="nucleotide sequence ID" value="XM_003859556.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13393011"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1030"/>
    <dbReference type="OMA" id="SWNMYRG"/>
    <dbReference type="OrthoDB" id="261977at2759"/>
    <dbReference type="PhylomeDB" id="E9BCC0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004027">
        <property type="entry name" value="ATP-binding cassette subfamily A, member 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF262">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1460"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1600"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1641"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1685"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1724"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1757"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1792"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1833"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="810"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="2129"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1262"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1320"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1971"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2094"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2369"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2612"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2660"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1325"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2372"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2612"/>
            <end position="2621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2668"/>
            <end position="2679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2679" mass="292325" checksum="026B46B06887D62D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE17</accession>
    <accession>A0A3S7WV99</accession>
    <name>E9BE17_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprenyl synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_190210</name>
        <name evidence="4" type="ORF">LdCL_190007100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860200.1">
        <property type="nucleotide sequence ID" value="XM_003860152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BE17"/>
    <dbReference type="SMR" id="E9BE17"/>
    <dbReference type="GeneID" id="13386012"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0240"/>
    <dbReference type="OMA" id="VNGMYYY"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="PhylomeDB" id="E9BE17"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
        <property type="entry name" value="AttH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07143">
        <property type="entry name" value="CrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17186">
        <property type="entry name" value="Lipocalin_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AttH" evidence="3">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="742" mass="82436" checksum="D0159D961ED0068F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE54</accession>
    <accession>A0A3S5H757</accession>
    <name>E9BE54_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_190590</name>
        <name evidence="9" type="ORF">LdCL_190010900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860237.1">
        <property type="nucleotide sequence ID" value="XM_003860189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13386049"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0650"/>
    <dbReference type="OMA" id="VMYDYEL"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="PhylomeDB" id="E9BE54"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001657">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001843">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="731"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="954"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="954"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1328"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1564"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1674" mass="174341" checksum="A186277FF6C356A0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEN0</accession>
    <accession>A0A3S7WW35</accession>
    <name>E9BEN0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_200830</name>
        <name evidence="2" type="ORF">LdCL_200013000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860423.1">
        <property type="nucleotide sequence ID" value="XM_003860375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEN0"/>
    <dbReference type="GeneID" id="13386210"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1040"/>
    <dbReference type="OMA" id="ATNCGLY"/>
    <dbReference type="OrthoDB" id="263013at2759"/>
    <dbReference type="PhylomeDB" id="E9BEN0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="333" mass="35635" checksum="BE1DAF2AE3649F77" modified="2011-04-05" version="1">MPLFSSGNTPVMPPTPTSAAKDAPQGPSGFSRAAALTYRTAPHPSDSTDGVFEALLMLAADRLNPNGEAMKENSSSGASHSKKGSWFGRAWRHVVDYATNNLLKMRQADFLNAFSRQLEVNPAEESSTVMVSCQCFIVSGGKLRFGSLFATNCGLYFCSCAPEAAPAAAAAAESDAGATSSAGLRGAEDEVEYIKERILFTDVASLLPSIFLEQNGTATPFIQGIPNGVVAPTALQVFTVQLSTVLQFLHLHNVGVKRPKRSAAEAEKGGAGAVQEAPCIDVVQKHEFNLVCELPPSLDTLKFCALLWRLWAQRLHDLGRPLEHPAVHYAEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGN4</accession>
    <accession>A0A3S7WY10</accession>
    <name>E9BGN4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_240220</name>
        <name evidence="9" type="ORF">LdCL_240007100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861112.1">
        <property type="nucleotide sequence ID" value="XM_003861064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGN4"/>
    <dbReference type="GeneID" id="13390562"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0260"/>
    <dbReference type="OMA" id="FVHDNSF"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="PhylomeDB" id="E9BGN4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001689">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001690">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000124">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="196"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="543" mass="57987" checksum="ACFF00C195D53053" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGR7</accession>
    <accession>A0A3Q8IG18</accession>
    <name>E9BGR7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="1">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_240550</name>
        <name evidence="3" type="ORF">LdCL_240010300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="1"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861145.1">
        <property type="nucleotide sequence ID" value="XM_003861097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGR7"/>
    <dbReference type="GeneID" id="13390831"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0660"/>
    <dbReference type="OMA" id="GYQKCLL"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="PhylomeDB" id="E9BGR7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF1">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Methyltransferase TRM13" evidence="2">
        <location>
            <begin position="218"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="462" mass="50823" checksum="F7C5BC5A207698A8" modified="2011-04-05" version="1">MTDAMKNLATALEGSPVSLEHEGPLQDAHLIAIRDLATSATVTDLRSRLLNGSLCPRGATSLTAALWNKTSVRDYQKCLLAARQARLDAGHSFNGYDHLAEAGAAMRSAMCSDVAEPKTCAEWARLIDLYTSFLPDRSHIHELENLPQEIAIGELLRETVERVRRAEDHAGGDGFALDCVVDVGGGNGFLAAQVAERLQCDSVVIDPFFPAHSIDCCPRLWPDTAHRARPATRRQRTLHRTVALFRDVRWSDAVPATPARTALIAKHLCGSGVDEVLRHLEAQESLPRILVLAPCCFNKITVDRYCDAAYLRQVMGIGSEEALARVNRLTDWNMSCYQSTHERMLARVEAARRSSATSGRGCACEVQIAMEASASQALPAVDGSSAATAPLFCYQRRSGPRSIANSITCTHDFALLVEALLNYGRMQWLQQRHYDVHLVQYVPDVVTPKNKCWLAIRQAHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIK0</accession>
    <accession>A0A3S7WZZ9</accession>
    <name>E9BIK0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_261890</name>
        <name evidence="3" type="ORF">LdCL_260024400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861774.1">
        <property type="nucleotide sequence ID" value="XM_003861726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIK0"/>
    <dbReference type="GeneID" id="13389021"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2450"/>
    <dbReference type="OMA" id="CTYAQRL"/>
    <dbReference type="OrthoDB" id="275980at2759"/>
    <dbReference type="PhylomeDB" id="E9BIK0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="2">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="734" mass="82623" checksum="B7C3CAEBF1329AD0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIZ7</accession>
    <accession>A0A3Q8IHI0</accession>
    <name>E9BIZ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium uniporter protein, mitochondrial, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_270640</name>
        <name evidence="12" type="ORF">LdCL_270012900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861920.1">
        <property type="nucleotide sequence ID" value="XM_003861872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIZ7"/>
    <dbReference type="GeneID" id="13389180"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1020"/>
    <dbReference type="OMA" id="DWDIMEP"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="PhylomeDB" id="E9BIZ7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF54">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="11">
        <location>
            <begin position="118"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35860" checksum="E579BFEF5808FAC0" modified="2011-04-05" version="1">MQPVSGTIFRRSGGLLPSAQSTSTLSHWRRRLSTLGRRFATARAAHASAPTSSALSAHDFAAITPLLLLRQMLQQHTQLDGIDLGAQLHPGKQHIVISRTKFCHFCAASHVEDPDAALADLEAAGVVVVLDGGSMVHLRPVLYLETLEMICNVARPSSSGNETSETNSKPSVAVRSFMVEEAERRVATLTEREKAMRNRLQPAIARAARWRRTVWGAALLYAGAQLAIISRLTYFDLDWDIMEPVSYMITVANTLFFFLYYLRFNEEHSYTAFDQRFLPRKVRQYAPRDFDWAAYADVCQQLVEERAMLDSMSKWSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>E9BK82</accession>
    <accession>A0A3Q8IQB2</accession>
    <name>E9BK82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HIT zinc finger/Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_280440</name>
        <name evidence="12" type="ORF">LdCL_280007900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862143.1">
        <property type="nucleotide sequence ID" value="XM_003862095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BK82"/>
    <dbReference type="GeneID" id="13386879"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0390"/>
    <dbReference type="OMA" id="TIVWRCE"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="PhylomeDB" id="E9BK82"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="11">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="633" mass="71045" checksum="90E1DC0636CF8B9A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKM5</accession>
    <accession>A0A3Q8IDK9</accession>
    <name>E9BKM5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucose-regulated protein 94</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Lipophosphoglycan biosynthetic protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LDBPK_290790</name>
        <name evidence="18" type="ORF">LdCL_290012700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Molecular chaperone that functions in the processing and transport of secreted proteins. Required for the synthesis of lipophosphoglycan (LPG), a cell surface glycoconjugate. Necessary for the attachment of the galactosyl residue to the mannose within the phosphoglycan repeats of the nascent LPG chain. Also required for addition of phosphoglycan to acid phosphatase. Not required for normal growth. Has ATPase activity. Binds heparin with micromolar affinity which may facilitate infection of host cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862496.1">
        <property type="nucleotide sequence ID" value="XM_003862448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKM5"/>
    <dbReference type="SMR" id="E9BKM5"/>
    <dbReference type="GeneID" id="13387235"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1080"/>
    <dbReference type="OMA" id="QFGKHIR"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="PhylomeDB" id="E9BKM5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000054">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000014">
        <property type="entry name" value="Lipophosphoglycan biosynthetic protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730288" description="Endoplasmin homolog" evidence="17">
        <location>
            <begin position="25"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="727"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="155"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU80564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="771" mass="86956" checksum="E898560520EC5F21" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLN5</accession>
    <accession>A0A3S7X3A2</accession>
    <name>E9BLN5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_301420</name>
        <name evidence="17" type="ORF">LdCL_300019400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862855.1">
        <property type="nucleotide sequence ID" value="XM_003862807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLN5"/>
    <dbReference type="GeneID" id="13385562"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1800"/>
    <dbReference type="OMA" id="MIHHENT"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="PhylomeDB" id="E9BLN5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000601">
        <property type="entry name" value="Atypical/RIO/RIO2 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="327"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU80939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ36163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="486" mass="55474" checksum="23B1F89B13EB96F9" modified="2011-04-05" version="1">MVKLNVTLLRFMEDEDFRVLTALEMAMRNHDVAPTALVERIAQLPHGGCRKRLNNLLKHKMIHHENTMYDGYAMKYGAYDYLALRTLSKRGTCTGVGHRIGCGKESDIILVRDEAGHECVLKLQRLGRCSFRSVARNRDYKGNGRARHGESWFYLSRLASQKEYSFMKLLYDEGFPVPKPIDQNRHALLMELVPGTLLNNITELGDASKVYRRALELMVKLAESGLIHGDFNEFNLMITDDQRVIMIDFPQMISINHPNASELFDRDVQNLANFFHRRFKVDTTWFPSLEKDVVRKGELDKQVYASGHFTRKQQEDLERLMLEGFQRSEKSDDEAGSQVLDSDASDDDGDENASQRSDIGNADVDAGVAGKFTSIPGGARGGESDEEREDSSDDDASEGRLLDEAMGAARERREGEVYARNPDRNANFLPDGKINEDHVKHQIRKNIRRKDNHDFNRHLHRNVQKGRQKQKIQRQLKSSNGGGFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQN0</accession>
    <accession>A0A3Q8IHA9</accession>
    <name>E9BQN0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_340760</name>
        <name evidence="2" type="ORF">LdCL_340013100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864241.1">
        <property type="nucleotide sequence ID" value="XM_003864193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQN0"/>
    <dbReference type="GeneID" id="13392650"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1240"/>
    <dbReference type="OMA" id="LFEYPNN"/>
    <dbReference type="OrthoDB" id="272609at2759"/>
    <dbReference type="PhylomeDB" id="E9BQN0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF1">
        <property type="entry name" value="MANGANESE_IRON SUPEROXIDE DISMUTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="486" mass="51583" checksum="E4F2BCEB9AD82D7B" modified="2011-04-05" version="1">MRPEAAAAELRRLLPLLSFTGRRTGAATHSVASLVVSTAYSATAARSVTNHSRDCPVLSKKLPLSLIGKESSFAARPCLSCVRERVHYVSSVSFCHYFEKKCAEAQHHQNGASSNGVVGTAALPNLLLEAIERSYGSVNAFKDSVALHSTGAMSPGRLWIVYTPPISGSEHGAVSLLNLPACRVPLVHGLWPLAVINMTEKRLCEQIACRSGKGGDAVDADNAPAWCHAARTPKTLGALATTEEGNDRAGSVAQVRLSSIQSAIAEEALSAMNWKFVEMQLTSALAYYSSKVRKQTQREHRKEREHVAAVRAMSQLKDSGAVIHATDWVTITSSNSFVASPASEPSLSAAAAVTSSSSAKTENSALGEANTQTAAVAVPSAEATATNTASNSAQPADNTAAGAAAAEPRIVQQADGTWEYHYNNGSVTKAYPDGTKVFQTESWTTTVFVNGDTLFEYPNNTSILDRADGVRVTTYADGTKKEERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BT22</accession>
    <accession>A0A3S7XA07</accession>
    <name>E9BT22_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional</fullName>
            <ecNumber evidence="13">2.7.8.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_355030</name>
        <name evidence="13" type="ORF">LdCL_350055400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.27" evidence="13"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865080.1">
        <property type="nucleotide sequence ID" value="XM_003865032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BT22"/>
    <dbReference type="GeneID" id="13387958"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350055400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6600"/>
    <dbReference type="OMA" id="SGAIHCG"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="PhylomeDB" id="E9BT22"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="12">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="385" mass="42645" checksum="25B754C92F6DAAAF" modified="2011-04-05" version="1">MTSHVTVHDVDGDEDIETDLVPWYKQPLPLGTQVMRFILLLLLTVMFLGVAILVANARMPDPKKVRPLPDLLLEWIPKVTLVENGSNVIIFLLNATTVVVGFKVFLLERHMNGLPSVTFLVGIPKIGSFLNRIAFGVVDSGRRPFPLKNVFPIMTIRFLTSYAVVMVFRTFVIMGTSYPATDNHCQNPQVIEHPVLNVILTLVTLSSGAIHCGDLMFSGHTMILSLAFILAWDYSPFLHPWAVRVWVSALLPISYYCILASRSHYTDDILVAMYVMIATYKLIDHAETGAPWQMQLLIRWMPWPGTNAIEEKWAAEEVVVVVQTPAEDSTDASAAVPEHENPIKETLPAQTATGGSSSSGTPLLRMHDSPSIGHLHSGVRETTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9BV59</accession>
    <accession>A0A3Q8ILJ6</accession>
    <name>E9BV59_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_367030</name>
        <name evidence="11" type="ORF">LdCL_360082900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865814.1">
        <property type="nucleotide sequence ID" value="XM_003865766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BV59"/>
    <dbReference type="SMR" id="E9BV59"/>
    <dbReference type="GeneID" id="13386668"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360082900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9390"/>
    <dbReference type="OMA" id="AGMCFWT"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="PhylomeDB" id="E9BV59"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU84109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21798" checksum="3EF7AEA9CF37D75B" modified="2011-04-05" version="1">MALPEQGPHTPPPLWCTAVAAQLTTPLYVLTVAPVEKVKVQLQMLGQGGKESSTVAGPVSCLLHIIRVEGYRGIFSGYTPTLMSHLIGLPFYFMGCQTARTTLLDTPLASMAAGREVVVPMLSGMVAGMCFWTSNYPCDFLKTCVQASKKKVSISDIICTTYAAGGVSAFYRGYTACFLRSLPANASGWLGIELVTTFIIGRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-02-22" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G9CU80</accession>
    <name>G9CU80_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Core histone H2A/H2B/H3/H4 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Core histone H2A/H2B/H3/H4/Histone-like transcription factor (CBF/NF-Y) and archaeal histone, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Histone H3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Histone_H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">H3</name>
        <name evidence="13" type="ORF">CGC20_36510</name>
        <name evidence="14" type="ORF">CGC20_36515</name>
        <name evidence="15" type="ORF">CGC20_36530</name>
        <name evidence="16" type="ORF">CGC20_36535</name>
        <name evidence="17" type="ORF">CGC21_25050</name>
        <name evidence="18" type="ORF">CGC21_25055</name>
        <name evidence="19" type="ORF">CGC21_25070</name>
        <name evidence="20" type="ORF">CGC21_25075</name>
        <name evidence="5" type="ORF">LdCL_160010700</name>
        <name evidence="6" type="ORF">LdCL_160010800</name>
        <name evidence="7" type="ORF">LdCL_160011100</name>
        <name evidence="8" type="ORF">LdCL_160011200</name>
        <name evidence="9" type="ORF">LDHU3_16.0690</name>
        <name evidence="10" type="ORF">LDHU3_16.0700</name>
        <name evidence="11" type="ORF">LDHU3_16.0730</name>
        <name evidence="12" type="ORF">LDHU3_16.0740</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2012" name="Microbiology" volume="158" first="328" last="337">
            <title>The histone H4 lysine 14 acetylation in Leishmania donovani is mediated by the MYST-family protein HAT4.</title>
            <authorList>
                <person name="Kumar D."/>
                <person name="Rajanala K."/>
                <person name="Minocha N."/>
                <person name="Saha S."/>
            </authorList>
            <dbReference type="PubMed" id="22016570"/>
            <dbReference type="DOI" id="10.1099/mic.0.050211-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1S</strain>
        </source>
    </reference>
    <reference evidence="5 21" key="2">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="JF742060">
        <property type="protein sequence ID" value="AEV56638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G9CU80"/>
    <dbReference type="SMR" id="G9CU80"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0740"/>
    <dbReference type="OrthoDB" id="262106at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000077">
        <property type="entry name" value="Histone H3 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AEV56638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5428917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5428918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5428921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5428922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP40952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP40956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP51178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP51179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP51182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP51183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="130" mass="14623" checksum="34C21558D49A25CA" modified="2012-02-22" version="1">MSRTKETARAKRTITSKKSKKASSGASGVKKSHRRWRPGTCAIREIRKFQKSTSLLIQCAPFQRLVREVSSAQKEGLRFQSSAIMALQEATEAYIVSLMADTNLACIHAKRVTIQPKDIQLALRLRGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-08-02" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q4JHM7</accession>
    <accession>A0A0R4J6X0</accession>
    <accession>E9BA26</accession>
    <name>Q4JHM7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_7835</name>
        <name evidence="17" type="ORF">CGC21_36690</name>
        <name evidence="16" type="ORF">LDBPK_091410</name>
        <name evidence="14" type="ORF">LdCL_090020500</name>
        <name evidence="15" type="ORF">LDHU3_09.1660</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2000" name="Infect. Immun." volume="68" first="5595" last="5602">
            <title>Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library.</title>
            <authorList>
                <person name="Melby P.C."/>
                <person name="Ogden G.B."/>
                <person name="Flores H.A."/>
                <person name="Zhao W."/>
                <person name="Geldmacher C."/>
                <person name="Biediger N.M."/>
                <person name="Ahuja S.K."/>
                <person name="Uranga J."/>
                <person name="Melendez M."/>
            </authorList>
            <dbReference type="PubMed" id="10992459"/>
            <dbReference type="DOI" id="10.1128/IAI.68.10.5595-5602.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2005-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Flores H.A."/>
                <person name="Ogden G.B."/>
                <person name="Zhao W."/>
                <person name="Park W."/>
                <person name="Melby P.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="10">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="DQ087966">
        <property type="protein sequence ID" value="AAY88232.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858819.1">
        <property type="nucleotide sequence ID" value="XM_003858771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q4JHM7"/>
    <dbReference type="SMR" id="Q4JHM7"/>
    <dbReference type="GeneID" id="13392167"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1660"/>
    <dbReference type="OMA" id="RITIEAC"/>
    <dbReference type="OrthoDB" id="3360192at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000043">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAY88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5427930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP41653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="111" mass="12272" checksum="8947FC9F7960FC43" modified="2005-08-02" version="1">MASSRSAPRKASNPHKSHRKPKRTWNVYVGRSLKAINAQMSMSHRTMKIVNSYVNDVMERICTEAASIVRANKKRTLGAREVQTAVRIVLPAELAKHAMAEGTKAVSSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9A6</accession>
    <name>A0A3Q8I9A6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Surface antigen protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_120012600</name>
        <name evidence="12" type="ORF">LdCL_120013100</name>
        <name evidence="13" type="ORF">LdCL_120013500</name>
        <name evidence="14" type="ORF">LdCL_120014000</name>
        <name evidence="15" type="ORF">LdCL_120014500</name>
        <name evidence="16" type="ORF">LdCL_120015000</name>
        <name evidence="17" type="ORF">LdCL_120015500</name>
        <name evidence="18" type="ORF">LdCL_120016000</name>
        <name evidence="19" type="ORF">LdCL_120016500</name>
        <name evidence="20" type="ORF">LdCL_120017000</name>
        <name evidence="21" type="ORF">LdCL_120017500</name>
    </gene>
    <organism evidence="12 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 22">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9A6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1240"/>
    <dbReference type="OrthoDB" id="267901at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF642">
        <property type="entry name" value="INACTIVE LEUCINE-RICH REPEAT RECEPTOR KINASE XIAO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599580" evidence="10">
        <location>
            <begin position="33"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU76991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU76995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU77015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU77020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU77025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU77030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU77035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="386" mass="40958" checksum="4E83BBBFBA52B8DE" modified="2019-04-10" version="1">MALCVRRLVLAATLAAVVALLLCTSSAPVARAVKEDNLTETQKSNTLKVLQAFARAIPEVKKLWTGEDFCSWKYVYCYPSAVGVLMDSVDYAGTLPEMPADVDYTNVVITQLDFSAKGQRLSGTLPASWSSMTSLMSLWLEGCERVTGTLPASWSSMKALSSLNLHGTQVSGSLPPQWSSMTSLATLYLRLTKVSGSLPPQWSSMASLTLLDLQGAKVSGSLPSEWREMKSAEVLQLQDCDLSGSLPSSWSAMPKLREVLLSGNHFCGCVPESWTSTQRIAVTIEDEHKGSKCKLENKCRQAAPTTTATPTATPTPAPETECEVDGCEVCEGDSAARCARCREGYFLTSEKTCRANGDGGVAAVSSGAAAAAAVCMAVLLSVGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA12</accession>
    <name>A0A3Q8IA12_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150006000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA12"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0140"/>
    <dbReference type="OrthoDB" id="272412at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="797" mass="84770" checksum="8D1D3194E3EBD3E7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB75</accession>
    <accession>E9BJZ8</accession>
    <name>A0A3Q8IB75_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Splicing factor 3B subunit 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Splicing_factor_3B_subunit_1_putative/GeneDB:LmjF.28.2570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_282780</name>
        <name evidence="5" type="ORF">LdCL_280032900</name>
        <name evidence="6" type="ORF">LDHU3_28.3760</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862376.1">
        <property type="nucleotide sequence ID" value="XM_003862328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB75"/>
    <dbReference type="GeneID" id="13387112"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3760"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000682">
        <property type="entry name" value="Putative splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000987">
        <property type="entry name" value="Putative splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000737">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="4">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5431660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113875" checksum="AB0B2B8F388147BB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBW5</accession>
    <name>A0A3Q8IBW5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_210012000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBW5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0770"/>
    <dbReference type="OrthoDB" id="272656at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="639" mass="70218" checksum="AD434CA2EA92D2D1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC60</accession>
    <name>A0A3Q8IC60_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3'a2rel-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_220012100</name>
        <name evidence="5" type="ORF">LdCL_220012300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC60"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0910"/>
    <dbReference type="OrthoDB" id="249924at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599590" evidence="3">
        <location>
            <begin position="42"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="360" mass="37070" checksum="5DEB84C371BD3555" modified="2019-04-10" version="1">MCPVPHQGLQRNRSPRGSTARMLQRALLLVALLCSFSLMTAVVTTPRGDGVHGTLCVSALHGAVLGRGKGLRAPPLTVPLLQPVALPHHTGSAVVVAAARADGDVDDIVTFSQAGDVFALEESASASVPSSSSSGVSPGANGRGSKAARAPETPASSSLSVEPLPRGSSAVSSLRRSLLLPSAADIVVVLVGEGDAGTELPPSSSAPPPDNFGTRRAPAMRLALLGLIALVVPAAIIALAMWCVCRRTRYKRKVKGLRLNGTRQPGEVDDVDMGNIVRGGDWLNLGAATPGRTKIGANGARFSILAPSTAACVRMDATFDPIGQQAAETRQRKRARRVARSGGGVPPSLRQHARGSLLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDA8</accession>
    <accession>E9BC56</accession>
    <name>A0A3Q8IDA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_1860</name>
        <name evidence="2" type="ORF">LDBPK_150150</name>
        <name evidence="1" type="ORF">LdCL_150006400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859540.1">
        <property type="nucleotide sequence ID" value="XM_003859492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDA8"/>
    <dbReference type="GeneID" id="13392902"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0210"/>
    <dbReference type="OMA" id="AHCICGQ"/>
    <dbReference type="OrthoDB" id="263245at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP47790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="182" mass="19370" checksum="5C8F13A25AFD8B2F" modified="2019-04-10" version="1">MAFATCHYIVEEDCEDFSDVPLKLHSFLEFLDAGLPSTDGSNTEQHVSSNISEKSEGEWLESDIRHSLRGAPLKAAADRPRRCYCLDDAHCICGQFFLPPLLTRNAAGALPPLTHGLATSGSEADAVDAAHTSSTATMSSFGEPMYISLCPNPVKVATPVPVISLTTMSMASASTTTTGCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IED5</accession>
    <name>A0A3Q8IED5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_190005500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IED5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0060"/>
    <dbReference type="OrthoDB" id="260777at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000067">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="265" mass="28725" checksum="C38DD38050652934" modified="2019-04-10" version="1">MADTQPAQEAPAADVPRAERNFGRGRGGRGGRGRGRGGPGEEKEWVPCTKLGRLVKAQKVTSLEEIFLFSMPIKEHQIVDTLIAEGQLHDEMMKIYPVQKATSAGQRTRFKAFNVVGDCDGHIGIGARVGKEVSLAIRASMIAAKLNIVPVRRGYWGNKIGEPHTIPMKVTGKCGSVAVRLVPAPRGTGIVAAPVPKKILELAGVEDVYTSSRGKTRTHGNLIMATFYALRKTYGFLTPDLWAETEPSRDPTDEHAELLAEMTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK2</accession>
    <name>A0A3Q8IEK2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Treble clef zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290029000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3380"/>
    <dbReference type="OrthoDB" id="248294at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317">
        <property type="entry name" value="BLR8090 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37317:SF6">
        <property type="entry name" value="ZINC-RIBBON DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="322"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Treble clef zinc finger" evidence="2">
        <location>
            <begin position="395"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="463" mass="49818" checksum="B0D57BABC452443E" modified="2019-04-10" version="1">MGRVGQARGARGAAKAKKEAGAVYSKGAASLSRRAQPIAASAQQRSASSLPTSINADEQLEESVAFSIRGSSSQEEAAESVEQESKRAGGNLCPSPPAQRKRASLRSARGRGSARRLEATEARDAVDETDATMGGDSDEFSEPPTEDPMGTTLEEAFGGDDEPKRESGERCSGSGTETRLDGVTQAEEGDGTAVTRRARRYNLKTSIVDADAGEADATSTSSPEDSEECAADTAAVDEDTANRYLALAFPELAAEYAAAGDGANAIPVNEVMTDSAVVAAWRCVKCDHVWRSGVFVRCILKSGCPQCAANRTSTLAKARPELLQLWDYNRNNPFLKPEEISADSRESVFWKCPMCRESYAARVKDRALDKVRCPSCALLRSQSAAVLASEESVVLQEWHPLKNGDLHIEQLSPTDTKTKVWWLCAGCGHEWEASLAARLARWRRSRRSLCPVCHGKGVTELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEN8</accession>
    <name>A0A3Q8IEN8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein grpe</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_300012800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEN8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0980"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000028">
        <property type="entry name" value="Putative co-chaperone, GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="256" mass="28555" checksum="AACD0D51BF78EC4A" modified="2019-04-10" version="1">MAARFDHRVRLHDILVRYSRGSVCTLTSISLVCGFLFFFASEKTPKDLHERMYRRVGANVAPLLCSHCVAQRKCCTEENTAGLSVAELKGKYEVLRAELCDSKRQIQKLRSENLYAAASCENIRKTTQEQSKQAHNDAVRSFARDMLDVCDALQVVTKKAVKYTQRNSSIPKSEAAVLAGVMLTEEVALKVLKRYGVTQMHTEVGATFDEEKEEKLFTVPSTPSLKEGSVAEIVKNGYDMNGSVLRRAQVGLSEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF07</accession>
    <name>A0A3Q8IF07_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_280030400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF07"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3420"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="474" mass="52320" checksum="C5225A10FAF7CC4B" modified="2019-04-10" version="1">MILRAAPASTHCRRSSSLPGNASLRDHDPEVHQLIHREMRRQIEGLELIASENFTSRAVLDCLGSVLTNKYAEGLPGNRYYGGTEVVDELEKLCVRRALAAFCLDAAVWGVSVQPYSGSPANLAVYTALLRPHDRMMGLSLQAGGHLTHGFYTATKRLSASSIFFESLPYPITPKGLVDYDQLAYLADIYKPRLIIAGGSAYPRDWDYKRYRQICDSVGAYFMVDMSHFSGLVAAREHNDPFEYADVVTTTTHKTLRGPRSGMIFFKKSIKQGKENVHLEDSISSAVFPALQGGPHLHQIAGIATQLKEVASPEWRTYIKQVKANAKALAATLTEGGETLVSDGTDNHLLLWNLRPHGLTGSKLEKLLDMVNITVNKNTIFGDKSAQAPYGIRLGTPALTTRALQEEDFRRVGQFLIRSVQLSKEVQKSAGSTKLADFVKAAETSKALQEMAEEVKAYARQFPYPGLESAYPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF33</accession>
    <accession>E9BM07</accession>
    <name>A0A3Q8IF33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_302640</name>
        <name evidence="1" type="ORF">LdCL_300032000</name>
        <name evidence="2" type="ORF">LDHU3_30.3540</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862975.1">
        <property type="nucleotide sequence ID" value="XM_003862927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF33"/>
    <dbReference type="GeneID" id="13385684"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3540"/>
    <dbReference type="OMA" id="EMTYLAP"/>
    <dbReference type="OrthoDB" id="270934at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12331" checksum="251A9626B9C6C543" modified="2019-04-10" version="1">MMQCPWDDVMTEAFRRAQMAGRVFPQLCDFPPSVPRDVAELKYLMPLRAFSEVGHGGTPTHTAPLWCGPLESTGFSDSMEGEEESLFMTYGGDAWSAALFVASNTRSGDSGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF64</accession>
    <name>A0A3Q8IF64_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340006100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF64"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0150"/>
    <dbReference type="OrthoDB" id="272349at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="596" mass="64776" checksum="9CC75B8D680EC56E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFL3</accession>
    <name>A0A3Q8IFL3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220018700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFL3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1680"/>
    <dbReference type="OrthoDB" id="267876at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="920"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1142" mass="120596" checksum="C9E835E14D4B76AB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGD6</accession>
    <name>A0A3Q8IGD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310023400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGD6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2840"/>
    <dbReference type="OrthoDB" id="988231at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="811" mass="88137" checksum="7C68BE59D2208F7F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGN6</accession>
    <accession>E9BQC2</accession>
    <name>A0A3Q8IGN6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_37680</name>
        <name evidence="2" type="ORF">LDBPK_331920</name>
        <name evidence="1" type="ORF">LdCL_330025900</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864017.1">
        <property type="nucleotide sequence ID" value="XM_003863969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGN6"/>
    <dbReference type="GeneID" id="13392413"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2820"/>
    <dbReference type="OMA" id="IYNEAMC"/>
    <dbReference type="OrthoDB" id="271206at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP53685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="430" mass="48393" checksum="196AE99A80EF9C88" modified="2019-04-10" version="1">MTEFKKLTTLADTLAQDVSTLKACCADDGDCDCNGSAASGVDSRLFACDAEHLHILSTRIREAVADGIPRLRKIVLKARETDPDRQIYNEAMCAKIEALFLVFCEALRPLAPDYFDTLTERDVSLPENAKERNVLDGLLDADFDPNVLLEESASLQAADNVHNHYILHRAKAEAWQSRVAQGLAEAVAFESQNRAFILAEEKVSRVAVLEAKRADKVCVTKIMEMRAELKWQTELQRRDAEQSLLKTAAAAISDIDAIPFFLASSISDEALRVTTAGHALQLIKALLSTPENMNIRRLRNNNEHLLCDYGHPCLSACDPETGERCVCHTVVSTAEVLWRRIGYTIRYTKVPNRSLDVLRSEAKARSLRLPCGRSLSVHNYEPMGFEDYSERLFELAEPDAMVRADEWMEWYAMMQRMESTLSSMIPRSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHZ8</accession>
    <name>A0A3Q8IHZ8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_280013000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="3"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHZ8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1010"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000044">
        <property type="entry name" value="RNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1970:FF:000002">
        <property type="entry name" value="RNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF36">
        <property type="entry name" value="PAP-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="275"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="455" mass="50694" checksum="386645178B0A0F08" modified="2019-04-10" version="1">MGYDMSIYIFGGLVTTGLLEVGGDVDFVGILDVEPGFAEAGEILRRSSSELRRLGLRSRAYPKARVPVLKADRVSRSLPGSPFHSLSCDGIFQFSRQVNAAEAESFRNRVESNYNATSVEWNSSYQFATVQFATTSSLIYGLANLKAHNEVEIPLRLPVDVRYGPEVYRFPFDFCLSSTGLRSSHVLGEALAQYPFSRHLLLVLKKWGRACGIINSIDGLLASYALTVMVVHFLSLVKAIPKVAAAKLNEGPKTLSPNPQYRPLEDARPDAMAEVGYLLATFLEYFGCAFDYQKSVVCTTNMTLTKATMGWDRDNGAIGKPPFFHFAIKDPYGLDNIARNLDLESTAYVQKAHDLAVKMVMEEFNDPMFLVSALTKDPRKPPRVVRSLSDRGIHSECIPSDQLEARHVLNKIQFQQRKRSMEDFGERAVKNKKNQSTASDVTKNVLGWIRNDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II42</accession>
    <name>A0A3Q8II42_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major Facilitator Superfamily/Sugar (And other) transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_350033600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II42"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3710"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="647" mass="69665" checksum="DFDA2A1D6A97A9C6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIH5</accession>
    <name>A0A3Q8IIH5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_38195</name>
        <name evidence="12" type="ORF">LdCL_140021000</name>
        <name evidence="13" type="ORF">LDHU3_14.1890</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIH5"/>
    <dbReference type="SMR" id="A0A3Q8IIH5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1890"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001301">
        <property type="entry name" value="NIMA-related kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000631">
        <property type="entry name" value="Serine/threonine-protein kinase NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5428689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP53400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="555" mass="61812" checksum="8E13B11067DD220C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ75</accession>
    <accession>E9BUT8</accession>
    <name>A0A3Q8IJ75_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Emp24/gp25L/p24 family/GOLD, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Emp24/gp25L/p24_family/GOLD_putative/Pfam:PF01105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_365810</name>
        <name evidence="4" type="ORF">LdCL_360065500</name>
        <name evidence="5" type="ORF">LDHU3_36.7710</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865694.1">
        <property type="nucleotide sequence ID" value="XM_003865646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ75"/>
    <dbReference type="GeneID" id="13388580"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360065500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7710"/>
    <dbReference type="OMA" id="KYLERFF"/>
    <dbReference type="OrthoDB" id="269988at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599610" evidence="2">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="32"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5435160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ39017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="235" mass="26425" checksum="B10876B44A8CAE0B" modified="2019-04-10" version="1">MMAASRVLVLVTVCLLCALCARVVAATSVHAGVYAKLLPGKEFCADYHAYRDPQSDPVPVTFHHRCIDPRLAGITTKLYGPSSEPLKRGPEIPLSETIDTFGDISQILFYAEKTGIYKMCFLLPLKKPAMRFEMSFSAANDIVEPPKVEDGAFVVDKPPEMADYADRLRMLNLSVETTVDELRMYQTRRYFFDKTVNSAFCVCVFSVLLNIAIAVGLTLWSEKYLKRYFVKQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJE9</accession>
    <name>A0A3Q8IJE9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_320030900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJE9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320030900"/>
    <dbReference type="OrthoDB" id="271578at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17048" checksum="EEF5AC0D6C0C87EE" modified="2019-04-10" version="1">MPARRGKQRRSRICYSFDTVQMRFDYAHALPAPGLTAHCVVLVPSAGMPSAAAALHSTVKAGEDRQTVAEGATLLSAYQTALRVLRERCGAWPLCCGGNEDWSDAEQNSLGKPVGWLYLLAPRKIPLAEGSRVEMGRLCIQSTVLTMDRDGLLGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJN8</accession>
    <accession>E9BUB2</accession>
    <name>A0A3Q8IJN8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Snf7 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Snf7, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Snf7_putative/Pfam:PF03357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_27980</name>
        <name evidence="10" type="ORF">CGC21_14300</name>
        <name evidence="8" type="ORF">LDBPK_364040</name>
        <name evidence="6" type="ORF">LdCL_360047400</name>
        <name evidence="7" type="ORF">LDHU3_36.5420</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865518.1">
        <property type="nucleotide sequence ID" value="XM_003865470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJN8"/>
    <dbReference type="SMR" id="A0A3Q8IJN8"/>
    <dbReference type="GeneID" id="13388404"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360047400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5420"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5434982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP42054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="225" mass="25592" checksum="8159DE495A74A16F" modified="2019-04-10" version="1">MFNRLFGKEKQVQPSRSSGGGNTNTAKTMEDMDAAIELLEKREAALEKRMESELAKAKQLYAKKNTQGALQCMKRKKMYEEQLLNIGAQKQNLETLKFTVQNQSMNHEVLRAQIRAKDELKRSNKQMKAEKIEDNMDDLMEEMDKANQVSEALRQPLDNNFVDEDELMNELEMELDGMNLEETQVADAKLPEMPAVPSQKLPAQPVKTKTQEDEDALAALEAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKM7</accession>
    <accession>E9BQI7</accession>
    <name>A0A3Q8IKM7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA pseudouridine synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">tRNA pseudouridine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_25495</name>
        <name evidence="9" type="ORF">LDBPK_340330</name>
        <name evidence="8" type="ORF">LdCL_340008400</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864198.1">
        <property type="nucleotide sequence ID" value="XM_003864150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKM7"/>
    <dbReference type="GeneID" id="13392607"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0480"/>
    <dbReference type="OMA" id="GRRYEYY"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000035">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF9">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="545"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP39945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="701" mass="77757" checksum="9C463ABA935436D1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKR9</accession>
    <accession>E9BTX6</accession>
    <name>A0A3Q8IKR9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-4 sterol methyl oxidase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Fatty acid hydroxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_13625</name>
        <name evidence="9" type="ORF">LDBPK_362670</name>
        <name evidence="8" type="ORF">LdCL_360032700</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865382.1">
        <property type="nucleotide sequence ID" value="XM_003865334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKR9"/>
    <dbReference type="GeneID" id="13388268"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3630"/>
    <dbReference type="OMA" id="TWMWARL"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="206"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP48375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="402" mass="46202" checksum="4B0E435DE35A26A1" modified="2019-04-10" version="1">MELTKKRVKIPPIHKLRPGWSAVALHTVIYLLRHDFVTAIVATFVVQPLYHRLILQSTYLQRLSDPALFTLVFAVLCHCVPWAFFNGIFLFFDSLHPQYGIEGLRNNALLAPLGRRMAVYKLPRKPQQLPSAALIFSTMLHTAFNHYLVIPVVLYAYLVHTNSCALRAPPPETVIVGFTPEDVVNYMSGRNLKQIPISLVTITSHFLIANVINEMGFYIVHSILHSSPTLYRLFHKKHHMYTGTISIAAEYATPLEEILANAIPTTAYFAFMFFHYTREEASKSSFVTSARAWPLFITWMWARLWETYEVHSGYCFSDTWLGKLGLLHGHRARFHDFHHTHNVCNYGSGLFMDALLNTMDPYLIYRYPDKHPRTTTLREEDLKEPRDLEAGSEAMDEVRACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL67</accession>
    <accession>E9BNX3</accession>
    <name>A0A3Q8IL67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytidine and deoxycytidylate deaminase zinc-binding region containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cytidine and deoxycytidylate deaminase zinc-binding region family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_20645</name>
        <name evidence="6" type="ORF">LDBPK_322210</name>
        <name evidence="5" type="ORF">LdCL_320027500</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863635.1">
        <property type="nucleotide sequence ID" value="XM_003863587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL67"/>
    <dbReference type="GeneID" id="13390923"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320027500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2750"/>
    <dbReference type="OMA" id="PVMYALK"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="410"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="542" mass="57596" checksum="1BDFE634C0AFEDFA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILH7</accession>
    <name>A0A3Q8ILH7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_27485</name>
        <name evidence="3" type="ORF">LdCL_360058600</name>
        <name evidence="4" type="ORF">LDHU3_36.6860</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILH7"/>
    <dbReference type="SMR" id="A0A3Q8ILH7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360058600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6860"/>
    <dbReference type="OrthoDB" id="273522at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5435093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="360" mass="42933" checksum="C40694A056656F9E" modified="2019-04-10" version="1">MPLPPVESGPAAMTRRNFLVEMNRLRVSQYMPTRKQLEEEDLRIATIRQEEKRAKHAEWAESRRKAADSYNAAGTNSGRPLPGSVSRSMRASGKGQPAENTYKLEKEEEAAKKREYNRLYEQEAKHQLAIRQATLKQMHDDEVRQMEALRKVNEEEDRKVAEAHAQAMEEERQYMERLKQSNKRELAARKAEQQAKEARDRQLQELVNENNRHRAEMDERRLKNVTRMLHLQNEQFHREAMLNKKASEAKHYEEVAAIEERNRLLTKEEQEAAQRKKEQFRQEFEDCIARDKEFRRTHNYDEPMEVTRQRNELAAQSYRLVLEEERLQNAERRQQYRKDLMDQIMAKQTYRMTHLDEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM95</accession>
    <name>A0A3Q8IM95_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome oxidase subunit IX, putative</fullName>
            <ecNumber evidence="2">1.9.3.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cytochrome_oxidase_subunit_IX_putative/GeneDB:Lmj F.36.6995</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360086200</name>
        <name evidence="3" type="ORF">LDHU3_36.9740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM95"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360086200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9740"/>
    <dbReference type="OrthoDB" id="275540at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13750" checksum="6CF1B0E6DD29B173" modified="2019-04-10" version="1">MFRQALSVSKRTYMLAFNSKAKARPNFGLRGVGYWTSEVYHKPGQNYWMVVCCTGPFLLVGAIMMDGFWSKLDDISGGGPSALDYGWRSQDRKPWDFSFDIGEGYAAGPAVYRPASGAVDLGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INY0</accession>
    <name>A0A3Q8INY0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_260010100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INY0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0590"/>
    <dbReference type="OrthoDB" id="246407at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="105506" checksum="C437AA2C650353BB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQ36</accession>
    <accession>E9BJB4</accession>
    <name>A0A3Q8IQ36_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_32410</name>
        <name evidence="7" type="ORF">CGC21_30505</name>
        <name evidence="5" type="ORF">LDBPK_271840</name>
        <name evidence="3" type="ORF">LdCL_270025600</name>
        <name evidence="4" type="ORF">LDHU3_27.2810</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862035.1">
        <property type="nucleotide sequence ID" value="XM_003861987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQ36"/>
    <dbReference type="GeneID" id="13386770"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270025600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2810"/>
    <dbReference type="OMA" id="VYNMRWM"/>
    <dbReference type="OrthoDB" id="261530at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="354" mass="38710" checksum="BC0470BB51D02A12" modified="2019-04-10" version="1">MSAYDTEAVAAIPVAVLPPGIRHATLSMEAHEQNHLAIGMGGEKYLVVHPTYSLAPHLYSRRMLGAVLLVLLEVAVFLFTLLGLCTPCITVHKRKYFALLGGHGGSMTDPPGRNLSLIACSVLIIVLFVFSFIFSVVVACCVRCDQRARVSEELFNRELLELYGAQVHDDGRVYSAGGEPSALKDEGMWGPCCGFEANERSRRSRNTGISCLQCIVVTASLILEGAAVYNMKWMHRTAVASGETATYEKGFSVTVFALVLRLFQLLFYCYMAFHMLYIGSHRSMPRCQLIHTSSTRAAGVLSTHGEAASSGDQLAKIDSESGYPSKPRHSAADREGDREMELIPNSRTTLHSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISG1</accession>
    <name>A0A3Q8ISG1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310012900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISG1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310012900"/>
    <dbReference type="OrthoDB" id="265702at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="482" mass="49230" checksum="E8C0FF98B9F3760D" modified="2019-04-10" version="1">MSQPYSAVADATGKAYVDIRVCDLLVQQGSMPKGLDSDFQIDGLYVVLRCQGDVRRTSCLWSSASGASPAALRGSATQRGAAAGACEAQSDDALVWNEMFRVVVPPALPLSTPATSPRGPHSPSSADGGDPQGGFSAPYTPPLHRSGSASGAGGGLRDMSGGIALPMSTAASGGMRAAGSSGFPVSYAPQPSSLVISTPSLHSAAAQQQSSGDGNGARATEVGASHAPLFYPAIELELWRSAPLSENLLGRYTYHVPMELMQGGYALSNLDAVVERVVLLRTKEAPSIMGNLYGWSGHRLSLRLRVQAVGLAPLMAAWSPQQGSEATMTAASTIGSAAYPVPFPTGMLGNTVTGGPPYVAAGVYGAPLGTLNPVLVNLLAPLGVPTGGSGAGQLAPTMMMSMPGGMGGDNLHKPGQPPFFSMFPPASEAAANVGGRMFHPDVPGVLPATPQSSGQGILGDGDLTWQSGTTQPTVYPSYRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISP6</accession>
    <name>A0A3Q8ISP6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING-variant domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_310027400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3530"/>
    <dbReference type="OrthoDB" id="266286at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000912">
        <property type="entry name" value="RING-variant_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="913"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1224"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1257"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1292" mass="140306" checksum="BCB19FBBD478A5E0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISR1</accession>
    <accession>E9BMW6</accession>
    <name>A0A3Q8ISR1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CGC20_3125</name>
        <name evidence="23" type="ORF">CGC20_3180</name>
        <name evidence="25" type="ORF">CGC21_11230</name>
        <name evidence="26" type="ORF">CGC21_11280</name>
        <name evidence="24" type="ORF">CGC21_36880</name>
        <name evidence="21" type="ORF">LDBPK_311930</name>
        <name evidence="16" type="ORF">LdCL_090014900</name>
        <name evidence="17" type="ORF">LdCL_310027200</name>
        <name evidence="18" type="ORF">LdCL_310028700</name>
        <name evidence="19" type="ORF">LDHU3_31.3500</name>
        <name evidence="20" type="ORF">LDHU3_31.3730</name>
    </gene>
    <organism evidence="18 28">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 27" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 27">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="31" key="4">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="32" key="5">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 78-127</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="18 28" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 28">LdCL</strain>
        </source>
    </reference>
    <reference evidence="29" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="30" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="22" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="10">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863283.1">
        <property type="nucleotide sequence ID" value="XM_003863235.1"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="q=1-128"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="m=78-127"/>
    </dbReference>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISR1"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3Q8ISR1"/>
    <dbReference type="GeneID" id="13389457"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3730"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="31 32" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31 32">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="31 32">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU76535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU81399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU81414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAC5432619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAC5432632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CBZ36594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TPP41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP41426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP41691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TPP42561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="TPP42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="31">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="32">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="128" mass="14682" checksum="4B46DF6563C3E7FF" modified="2019-04-10" version="1">MQIFVKTLTGKTIALEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEEGRTLSDYNIQKESTLHLVLRLRGGVMEPTLVALAKKYNWEKKVCRRCYARLPVRATNCRKKACGHCSNLRMKKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITR1</accession>
    <accession>E9BPE3</accession>
    <name>A0A3Q8ITR1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetoplast DNA-associated protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Kinetoplast-associated protein 3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Kinetoplast-associated_protein_3_putative/GeneDB: LmjF.32.3780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_35240</name>
        <name evidence="5" type="ORF">CGC21_21445</name>
        <name evidence="4" type="ORF">LDBPK_323930</name>
        <name evidence="2" type="ORF">LdCL_320045300</name>
        <name evidence="3" type="ORF">LDHU3_32.5060</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863804.1">
        <property type="nucleotide sequence ID" value="XM_003863756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITR1"/>
    <dbReference type="SMR" id="A0A3Q8ITR1"/>
    <dbReference type="GeneID" id="13391567"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320045300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5060"/>
    <dbReference type="OMA" id="NAYRLTH"/>
    <dbReference type="OrthoDB" id="272590at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052695">
        <property type="entry name" value="Kinetoplast-DNA-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564:SF4">
        <property type="entry name" value="DNA-ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37564">
        <property type="entry name" value="KINETOPLAST DNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="136" mass="15988" checksum="9F6127192FBD1424" modified="2019-04-10" version="1">MLRRSFTLRRASPFSLFQKHLGETGVLKGVKNPTRKSAQMYSKLSTPERKMFEERARRVTYPALDAYNRFQKEYAPRFLHLPMKQRQRKVAQLWAELKKNGTVKIPKSAKRKIRKVAKKTKPRRSVTKTAKKKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IW63</accession>
    <accession>E9BU55</accession>
    <name>A0A3Q8IW63_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14020</name>
        <name evidence="3" type="ORF">LDBPK_363460</name>
        <name evidence="2" type="ORF">LdCL_360041500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865461.1">
        <property type="nucleotide sequence ID" value="XM_003865413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IW63"/>
    <dbReference type="GeneID" id="13388347"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360041500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4730"/>
    <dbReference type="OMA" id="EHRRAYV"/>
    <dbReference type="OrthoDB" id="267746at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019">
        <property type="entry name" value="KDA ANTIGEN P200, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="815" mass="92283" checksum="33A05766D25573AE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4X8</accession>
    <accession>E9B7F1</accession>
    <name>A0A3S5H4X8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_37290</name>
        <name evidence="5" type="ORF">CGC21_29815</name>
        <name evidence="4" type="ORF">LDBPK_020040</name>
        <name evidence="2" type="ORF">LdCL_020005600</name>
        <name evidence="3" type="ORF">LDHU3_02.0100</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5426966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000040">
        <property type="protein sequence ID" value="TPP43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000062">
        <property type="protein sequence ID" value="TPP44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857900.1">
        <property type="nucleotide sequence ID" value="XM_003857852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4X8"/>
    <dbReference type="GeneID" id="13390035"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0100"/>
    <dbReference type="OMA" id="FVECFYG"/>
    <dbReference type="OrthoDB" id="272807at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5426966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="397" mass="43143" checksum="E53BACAE30CF1FDD" modified="2019-04-10" version="1">MLKKVLKIKGVESRTALVEFAVNKRVKYLEYLKELHSEEGTLWMNTVHLDLHEIGKYFNIADACLPTDRDGVSKEGLIQLPAEKPVAVAASATGALASSSSSASAEPGATGADFINVSIANAPAAIRQRSSSAADWARYYLPCYAALAISLSEILVIPIGGEEFVECFYGLLLELEVAYASGAASKALAQRNLRQFRQHVSPGLKSLLQTSTDAETLDATPAFPVVTTSSDLDAQIKYLFLNQRHLEYMAASPSYDAVIPALCSVLMLAYRKLCDYELMREDECVRRILSIDKRLERLFFAHVSHEVGKIAKQKLLREAYILSTGALFADLVDASGRSGASGASGIDGGADFVADLLIQQQQRRGSSSPTTAEKKGFDSSDDDENDGTVWFGPEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H561</accession>
    <name>A0A3S5H561_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030013100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H561"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0880"/>
    <dbReference type="OrthoDB" id="267274at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="966"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1093" mass="114326" checksum="686E133C3B35C153" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5B9</accession>
    <name>A0A3S5H5B9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_040012300</name>
        <name evidence="5" type="ORF">LDHU3_04.0890</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812624">
        <property type="protein sequence ID" value="CAC5427200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5B9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0890"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5427200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="152" mass="15910" checksum="8F3F19404750E284" modified="2019-04-10" version="1">MARSRAAPRASGGSSHHAAASPPPKKAEPLHQSTPHAHPQQPNGVTNIYVQRPMAGGGGGGILGTMAAVAGGSVLGHGISNYLYGHSNQAPTQPAEAQQLAQAAQQEGHVCTPQLVGYSKCLEANPESADSCKWAWDYFTQCQREHPMQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Q7</accession>
    <accession>E9B8R0</accession>
    <name>A0A3S5H5Q7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_24315</name>
        <name evidence="3" type="ORF">LDBPK_060500</name>
        <name evidence="2" type="ORF">LdCL_060010100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858356.1">
        <property type="nucleotide sequence ID" value="XM_003858308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Q7"/>
    <dbReference type="GeneID" id="13391660"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0600"/>
    <dbReference type="OMA" id="PRNHYLV"/>
    <dbReference type="OrthoDB" id="275837at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="325" mass="35809" checksum="A3BAAD32B1C489B2" modified="2019-04-10" version="1">MPHIPRNHYLVVHDAIRKLLGPDAQLAAFVKAQHAFQCDMLVNDARTDPEELMRAGARHSGGGIGDDAAAKAGVGEFARRLQGVLGICDVVPHTRRVDVIFRDRSLIQLALGAAKRDLPYALETGADVNQEPDWRLRNRLRISLGYDEELFLAQCTRSMNVAARILEKCAFDSARYSALMSTNAAMAAMYEASGQRWQAVLPPVTYWQAHCYSLMKAYPCRHYQQIVATVEHNYAAYYGEFPMTNPYCDGEDLNTIQVVKWLCEAFNAGAAVSQVTSAASSPATSNEWQTVDCSMPAAMEDGDAEKGAAVMDNMTDGRSSQEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H634</accession>
    <name>A0A3S5H634_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Inositol phosphosphingolipid phospholipase C-Like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_080007000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H634"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0270"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU76322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="653" mass="71611" checksum="C9AA62353B676173" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H693</accession>
    <name>A0A3S5H693_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MIX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080016700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H693"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1560"/>
    <dbReference type="OrthoDB" id="268637at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.690:FF:000001">
        <property type="entry name" value="MIX protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040571">
        <property type="entry name" value="MIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18529">
        <property type="entry name" value="MIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial membrane-anchored protein" evidence="1">
        <location>
            <begin position="44"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="195" mass="22280" checksum="8F7A300902975754" modified="2019-04-10" version="1">MFRHTARRMSSLSSFTGIEVDPYTAKSMFLFGFIASVGFLSVYSVKETKKAGPIELPEELEAQRQRHNDPRRPPWPLLHQRVVLLREGKGAPEDIALMWEQTKHYYPADWLIPLELTQVLKYSSGKYLQTYVADPDEMRKEVLMQLLNVKYGRASDLKGGRVNKDVEEIISMAVDDLENMDLNPSADAVLIPTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H698</accession>
    <accession>E9B9L6</accession>
    <name>A0A3S5H698_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_081191</name>
        <name evidence="1" type="ORF">LdCL_080017300</name>
        <name evidence="2" type="ORF">LdCL_080018000</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858675.1">
        <property type="nucleotide sequence ID" value="XM_003858627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H698"/>
    <dbReference type="GeneID" id="13392010"/>
    <dbReference type="KEGG" id="ldo:LDBPK_081191"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081191.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1630"/>
    <dbReference type="OMA" id="YVIVWVE"/>
    <dbReference type="OrthoDB" id="267217at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="432" mass="43389" checksum="6FB636EAA94ADC34" modified="2019-04-10" version="1">MPLPLTSLARAMASPCAVAGSTTTGTAVAAGNSSGTDCYVIVWVEGRERPVYACTAPLPSSGSSASLPSAASAGAAAVPAVNVVTLRRFFGALVLLSSPPPAARARAGGHCAALSCAASFTRETAPVLCATLPLGLVGAFGASPPYYYVAVLAPGTAAVVGNQLLAWLASSVLAALHPDSWATAALPTGQACGTALLSLAADAPDLCSQLALYGAAEVGRARAGAAAMEDYGAREVLADSAGQSTLAAVLQEFEPCRDSPVAVAISTLLRRCWVPFTVSPATTAASLHISLAGYFTLPFPSCLRASSSAASPPAPTLYACSAGCWEALRLLASFCSRRTPDLQQTSSADAAPLAVLPLGGSSSGGAVALIAASVGYVHPDTALYQAVLVHGERPSRGGAVNCAAPYVRYLTTSEVAACGTPWHPDALRSVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6E7</accession>
    <accession>E9BA25</accession>
    <name>A0A3S5H6E7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_36695</name>
        <name evidence="4" type="ORF">LDBPK_091400</name>
        <name evidence="3" type="ORF">LdCL_090020400</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858818.1">
        <property type="nucleotide sequence ID" value="XM_003858770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6E7"/>
    <dbReference type="GeneID" id="13392166"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1650"/>
    <dbReference type="OMA" id="VEGNQMY"/>
    <dbReference type="OrthoDB" id="273375at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600567" evidence="2">
        <location>
            <begin position="31"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="607" mass="65622" checksum="24C091B2369D7903" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J8</accession>
    <name>A0A3S5H6J8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette subfamily A, member 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_110018400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1510"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001592">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF262">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="662" mass="73274" checksum="385F6AE942B026F5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6M4</accession>
    <name>A0A3S5H6M4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surface antigen protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_120018700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6M4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1320"/>
    <dbReference type="OrthoDB" id="1877432at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052592">
        <property type="entry name" value="LRR-RLK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054:SF82">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018621808" evidence="6">
        <location>
            <begin position="27"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="529"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="657" mass="69950" checksum="10F1089043E6DDC3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6V4</accession>
    <accession>E9BCE4</accession>
    <name>A0A3S5H6V4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S dicluster domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_1455</name>
        <name evidence="3" type="ORF">LDBPK_151050</name>
        <name evidence="2" type="ORF">LdCL_150016000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859628.1">
        <property type="nucleotide sequence ID" value="XM_003859580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6V4"/>
    <dbReference type="SMR" id="A0A3S5H6V4"/>
    <dbReference type="GeneID" id="13393015"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1340"/>
    <dbReference type="OMA" id="FNCTITC"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000017">
        <property type="entry name" value="Putative succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF45">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="197" mass="22428" checksum="F3499A8EE69F24F2" modified="2019-04-10" version="1">MPSAPLPGQLANYSSPLYMYRHLIKNSTAKTPQLYTAKDNSKTAMHLLTRRAANANYTVNRWYLKEKVDSSNRMRLEGLYECVLCASCTGSCPQYWWNREHFLGPAVLLQSYRWLVEPLDRDFDERVRMFETGNLVNMCHNIFNCSITCPKFLNPGLASKEIKRLSSPSAKRVGPAIEMEPVTSGKEAGKRSLAQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Y0</accession>
    <name>A0A3S5H6Y0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_160015200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Y0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1200"/>
    <dbReference type="OrthoDB" id="276735at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000737">
        <property type="entry name" value="Protein kinase putative (CRK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF552">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 2 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="472" mass="52596" checksum="A088A55CD2458F73" modified="2019-04-10" version="1">MSTAGRYKHVVKLGEGTYGSVYKGTEIQTGKVVAFKRMVVTSDDEGVPGAAIREICLLKELRHDNVVDLFEVLFEPPKITMIFELCDCDLKRFMESRPKRLLDAEAEMRPILKQIFIGLEYLHSRSVVHRDMKPQNIFVNVRAPDFAALTASPSPRQDHLQPPPFSGVPTAVGGDVQSAAGSDGRPNPFAGADSVPPWEAAAAAPSNTPNQLIVKIGDFGLARVEEIPVKKYSHEVVTLWYRSPDVLMGSALYSYPVDIWSMGAIFFEMATSKVLFSGRHEDEQLLRMFWLLGSPTRETWPSMLSYPGAMERLERASRAAAERPDLRFGSEVYVQQQQQQQQPPSSQSHSGSRAPDLLTQIAHKRFYHSLKAIQQREESARSSSNTYQLPVELWFDRPLFGEYMSATGFDSCVTAEGVNLLRQCLLYEPNHRITAAAAVRHAYLHAVSVPTAGALDVLMTSLLQTMEACHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H713</accession>
    <name>A0A3S5H713_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_170016800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H713"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1510"/>
    <dbReference type="OrthoDB" id="269747at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8261" checksum="FD33BE17D094FC2C" modified="2019-04-10" version="1">MSGVRVAAFSKYFAIGALCAALVCARHSAFLVADDSLQFQRVCTSVARYADEAAALEEYVESQGLSIAKIQSKMNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7F2</accession>
    <name>A0A3S5H7F2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin guanine dinucleotide synthesis protein B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_250028500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7F2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2750"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01983">
        <property type="entry name" value="SIMIBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003901">
        <property type="entry name" value="Molybdopterin_guanine_dinucleotide_synthesis_protein_B_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF4">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="4">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="445" mass="47839" checksum="B1539CDE4352DC95" modified="2019-04-10" version="1">MTNFIQPGGGSSTKSISVTIPSDGELIITVPSNEPKCSASIKLEPSTGATDSRVDVAGSPLVTDISYYLLPGVTLNVFAWTTSVIRIEGSEQLLRGVIRSSTKSITRPLVEYHFVLHTQRIAAEKTQCGGPVTLICGGQLTGKTVVARTLANYAARAGWKPMLVDLDPGVQQTIGLPGSIGAAILDYPLPLDEVMALSLVSTTYFVGTTEVESFSKLGEALMGAAYVHFSKLLLTCVRERLSTHANDLHGFSGAIIAVPEVHGSSGINFVSELIQQYDVSNVLCLGDDDLFHTLYLRHDRGNAAQPDYVKIDRISHNFSTVPPANADSVMPSRYSDYFLGTGVVDLHPSQWSKPFNSIDVLILKEEQGQVVLSPVPKEELQGIVGCIGALYSSKSGNALQSSPMAYARVQTIDPAGIYFLTSTHFTFPSEKLTLLVGTVRWITST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7P3</accession>
    <accession>E9BMG2</accession>
    <name>A0A3S5H7P3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRAL/TRIO domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">CRAL/TRIO domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_12155</name>
        <name evidence="3" type="ORF">LDBPK_310380</name>
        <name evidence="2" type="ORF">LdCL_310008900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863130.1">
        <property type="nucleotide sequence ID" value="XM_003863082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7P3"/>
    <dbReference type="GeneID" id="13385850"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0460"/>
    <dbReference type="OMA" id="YFNTARD"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055777">
        <property type="entry name" value="DUF7353"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF2">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24044">
        <property type="entry name" value="DUF7353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="992" mass="109933" checksum="A1C199463B00ABDD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPU2</accession>
    <name>A0A3S7WPU2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX family hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_070008500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPU2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0420"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="781" mass="84328" checksum="DF7CC883F5018053" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPW6</accession>
    <name>A0A3S7WPW6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_1055</name>
        <name evidence="12" type="ORF">CGC20_1060</name>
        <name evidence="13" type="ORF">CGC21_10295</name>
        <name evidence="14" type="ORF">CGC21_10300</name>
        <name evidence="7" type="ORF">LdCL_070010500</name>
        <name evidence="8" type="ORF">LdCL_070010600</name>
        <name evidence="9" type="ORF">LDHU3_07.0680</name>
        <name evidence="10" type="ORF">LDHU3_07.0690</name>
    </gene>
    <organism evidence="7 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000059">
        <property type="protein sequence ID" value="TPP45269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000059">
        <property type="protein sequence ID" value="TPP45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPW6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0690"/>
    <dbReference type="OrthoDB" id="270219at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000036">
        <property type="entry name" value="Putative 60s ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5427572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP52469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="264" mass="29745" checksum="517B4EB33C6B5071" modified="2019-05-08" version="1">MPGKEVKKATQPAKAASPYKKPAVASHFAARPKNFGIGQDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVPPALNQFTKVLDRASRNEALKLIKKYAPETRKARRERLHKAAEEKKKDPKKTVSTRAPLAVVTGLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLGDAIGRKTATCVAITDVNAEDEATLKNLIRSVNARFLSRSDVIRRQWGGLQLSLRSRAELRKKHARNAGVDAAAIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQS8</accession>
    <name>A0A3S7WQS8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase, putative</fullName>
            <ecNumber evidence="3">2.3.1.158</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090017600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.158" evidence="3"/>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQS8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1340"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="685" mass="77222" checksum="6558C8B92F866B39" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRD8</accession>
    <accession>E9BAG8</accession>
    <name>A0A3S7WRD8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_35535</name>
        <name evidence="14" type="ORF">CGC21_23295</name>
        <name evidence="13" type="ORF">LDBPK_101240</name>
        <name evidence="11" type="ORF">LdCL_100019400</name>
        <name evidence="12" type="ORF">LDHU3_10.1600</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000051">
        <property type="protein sequence ID" value="TPP52571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858958.1">
        <property type="nucleotide sequence ID" value="XM_003858910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRD8"/>
    <dbReference type="SMR" id="A0A3S7WRD8"/>
    <dbReference type="GeneID" id="13389254"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1600"/>
    <dbReference type="OMA" id="WGHKPET"/>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033253">
        <property type="entry name" value="CFAP45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504">
        <property type="entry name" value="NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="10">
        <location>
            <begin position="121"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5428082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP52571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="480" mass="57032" checksum="9A82A2595EE1772D" modified="2019-05-08" version="1">MSFFINKTCDVFPPRRRGQSDGALRKELNARGAPRDSAIITKTELDIIRGMIDGRFPGSLSGTAATAVAPRTHTEAAEEHRRRMQEFDAERARNGVAPRTAEEIEQAQLRQVNLEKARLMLDEECDEVKAMNRIIMEAKCVATREAQRLEKQKRIEEETVYNRQMDALMAQEAETAQQVYLERERQRMEEQRRNAAMIKAQLHERYVERVRRLERHQQEQDAMSRHIERLQVEEKAEKLRRIDAARRLMEEAAIANAEQIALKQREREMELEEDRKMAEYIKQKEARDEAYAEEQARLRREKDMEIARLRANQQRVQDKQAELEELRVRRVQEAYIREERRKEKEAAERESAMHADLQQARLAQVEERNRQKALEKVQEQEELDRMLAVQKISREQELERQARTRRLQEENSLALLKQMMDVEERRRRQRQEEIEEGNQLRKAARERQAALEAIRDRKLGELEELDVPEQYRRALLKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRW1</accession>
    <name>A0A3S7WRW1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin-related protein, putative</fullName>
            <ecNumber evidence="5">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120008300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="5"/>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120275.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0440"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="1878"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1533"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1560"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1646"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2175"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2579"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2840"/>
            <end position="2910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2947"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3065"/>
            <end position="3109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3148"/>
            <end position="3195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1423"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1646"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1665"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1696"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1715"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2579"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2894"/>
            <end position="2905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2947"/>
            <end position="2959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2976"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3086"/>
            <end position="3099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="3100"/>
            <end position="3109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3153"/>
            <end position="3171"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="2359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="2359"/>
            <end position="2365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3232" mass="335696" checksum="6C2B047E0A4961EC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSN3</accession>
    <accession>E9BBH9</accession>
    <name>A0A3S7WSN3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_17085</name>
        <name evidence="5" type="ORF">CGC21_33445</name>
        <name evidence="4" type="ORF">LDBPK_131050</name>
        <name evidence="2" type="ORF">LdCL_130015800</name>
        <name evidence="3" type="ORF">LDHU3_13.1280</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859316.1">
        <property type="nucleotide sequence ID" value="XM_003859268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSN3"/>
    <dbReference type="SMR" id="A0A3S7WSN3"/>
    <dbReference type="GeneID" id="13390743"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1280"/>
    <dbReference type="OMA" id="DPGYMTQ"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="320" mass="35899" checksum="9AA29B3DAAA09A4A" modified="2019-05-08" version="1">MPPTDPREWAKKVRAKTPQLLEVGKPVPKAVLSFGGCGFLVTYALGVALYLQQEKKELLANSFLLGAGSGVLPAVALACGPRAVNLERVRDFIVNNRFIVTDEEKRIETMAAGINQLLPKNAVDLVKGRLALTIGFSNKDPGYMAQAKENVYFGHHIAEWTDFDDLAQNIIAATAPNTQKPCVFRGADNVLRGTMMSLSSELDQYCRHVYIHGYAGYRYNKNQARHNIMFGRHGYVGNTHFSFPKQVLMAFAPLVGGDVRKDELLEAYDVGYNDARRYERWEEDPYYFAKADRSPSDDFNFRNLRANLFGGKSASERFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSW7</accession>
    <name>A0A3S7WSW7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_140010500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSW7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0690"/>
    <dbReference type="OrthoDB" id="265550at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="548" mass="59328" checksum="0750D28F8ADDD017" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTG3</accession>
    <name>A0A3S7WTG3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_150012700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTG3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0960"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="478" mass="51540" checksum="58E9ABD6A0705E80" modified="2019-05-08" version="1">MRQPEPHKCITSTADFFFAPPPPHCCCCFPSPPPFPHTLQRACWHFRCSSRFTDLRTHASPPLLLVFVRAARFTRPSTPSCLKPSPLFFFFVGSTQPVEVRMDSSAGGFFFPFGSPSTTDRCPGATTVDAADSTSSTLGTAVPSPPIWPPAKISTATFPWVSLDSDTLHEWAAGCCCVAPSNNVKCNLSTKPLQLKLRAVSPASAEGAPGEASSSADAKRSDIFTLCYQTSPEVDTLTSVAATQTPEMTPSSSAKRERRDVVPGRYYGGLKVWSCAVLLAEYLANHAAQYRSLFEAAVVVAELGCGQGLPGLAAMCLGARRVVFQDYNEEVLNVCTKPNVAATVCANESLQLSQGGVGTTPLLHVKFVHGDWVDLSWESQGAASSSAGLEAFCDVILGSDVTFDKDACDRLACVLHRWLRPYTGTAIIVSKDYYFGTNGGYLEFTESAEPYGLRVELLKRVDTADKMPHVVLRVTHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTN4</accession>
    <accession>E9BCC8</accession>
    <name>A0A3S7WTN4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_1530</name>
        <name evidence="3" type="ORF">LDBPK_150880</name>
        <name evidence="2" type="ORF">LdCL_150014300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859612.1">
        <property type="nucleotide sequence ID" value="XM_003859564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTN4"/>
    <dbReference type="GeneID" id="13392952"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1130"/>
    <dbReference type="OMA" id="FMAIYRN"/>
    <dbReference type="OrthoDB" id="267561at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="436" mass="46779" checksum="06455A627842B765" modified="2019-05-08" version="1">MTGLSRARGPSYDAESISSSITGSCPSAPAPFKYLTASSEVTCYQHPSFRSLELLLPAPLWSDAFVQERARYTLLPRHLFPFSSPSAGVIREPSSSYALDPASRTTATTAAALEEPRRASSADVGGRLSGRWSFMAIYRNFKRAREATATREKVAEVPRRACLAESPVEDALLLECPRCALSPSIRYLPSPSMSLVDGCSVAEVDDGDDYGEVVNVRGNGLSSPCSCSTTTSRAESIGAAAWHPTTVAVASEMGTKYAMVRECQMTRSASSVTAAVAATSLNAAHAEALRMFETVLDRVSVAHETRCPLCSPPRPPPWGRCAQPASLNGPLPALAPTARAGDAAPIYPEKSRVVASDLLDAHELSLDAEKQAGMEAHRLRLLRRARSLLNRHGDRLRYLSETKPSLFRETVQSHPLARACAQLGGLPLLRALSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUY8</accession>
    <accession>E9BDR9</accession>
    <name>A0A3S7WUY8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-7b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_3115</name>
        <name evidence="10" type="ORF">LDBPK_180890</name>
        <name evidence="9" type="ORF">LdCL_180014100</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860102.1">
        <property type="nucleotide sequence ID" value="XM_003860054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUY8"/>
    <dbReference type="GeneID" id="13385954"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1140"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000751">
        <property type="entry name" value="Rab family GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="223" mass="24113" checksum="AF42089665D9FE19" modified="2019-05-08" version="1">MSMKRQLLKIIILGDSGVGKTSLMHQYVNHIFDNRYKATIGADFLSKDVEVNGRVVTLQIWDTAGQERFQSLGSAFYRGADACILVFDVTQQESFAHVGSWLEEFSIQAGRRDSVLVGNKTDLEDRRQVASKTVQAWCAKQNAEAANVNNGAGAGAGDSAAPEMKYFETSAKDNAGVEEAFIAVVQLALARKATVEEATPMPQTVNLSQAQQEQAPSSSACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV32</accession>
    <name>A0A3S7WV32_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_180017400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV32"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1540"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04335">
        <property type="entry name" value="PrdX_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.960.10:FF:000005">
        <property type="entry name" value="Putative prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="260"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="723" mass="80876" checksum="E7D09C5361DAEE19" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVE2</accession>
    <accession>E9BE35</accession>
    <name>A0A3S7WVE2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Synaptobrevin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Synaptobrevin-type transport protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Vesicle-trafficking protein SEC22, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Vesicle-trafficking_protein_SEC22_putative/GeneDB:LmjF.19.0400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_9125</name>
        <name evidence="14" type="ORF">CGC21_19385</name>
        <name evidence="12" type="ORF">LDBPK_190400</name>
        <name evidence="10" type="ORF">LdCL_190009000</name>
        <name evidence="11" type="ORF">LDHU3_19.0450</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860218.1">
        <property type="nucleotide sequence ID" value="XM_003860170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVE2"/>
    <dbReference type="SMR" id="A0A3S7WVE2"/>
    <dbReference type="GeneID" id="13386030"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0450"/>
    <dbReference type="OMA" id="YYKKTVH"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000133">
        <property type="entry name" value="Putative synaptobrevin-type transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000023">
        <property type="entry name" value="Putative synaptobrevin-type transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="199"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5429426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP41840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP51026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="280" mass="30952" checksum="D701F7E155079058" modified="2019-05-08" version="1">MAANGCFIAALIARTHDRLPLCSYTDDNYSNANVIRQQEQRIVERMESPAGGTDRAAAKGSYYESFDHKDNVYFAFQDAATDLTLVVAVNKLLLRNSGDINGMNKLACGLLDLIFSEFIQMYTPAEIGAPNVRAYQFIKFDATLRKCVTRIMQQDRTTGDRIVVGSGTSGGSSGSGAGAGPSGGGVGATGMIRRQVNPQYDALRQEITDVHMVMRKNLEDLMTRGEGLDTMTNYSAELVDQSSRYYKKTVQMNRMRLLKTYGPPAAIGLFLIVFFYLYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVR9</accession>
    <name>A0A3S7WVR9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase KCMF1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_200008000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVR9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0360"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000038">
        <property type="entry name" value="E3_ubiquitin-protein_ligase_KCMF1_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="683"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="799" mass="89293" checksum="EB7E76EA88F62F09" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXU8</accession>
    <name>A0A3S7WXU8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">LdCL_230022900</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2100"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000009">
        <property type="entry name" value="Dynein heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000014">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000022">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000016">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000028">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002138">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="17">
        <location>
            <begin position="276"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="18">
        <location>
            <begin position="1452"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="2034"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="23">
        <location>
            <begin position="2535"/>
            <end position="2662"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="26">
        <location>
            <begin position="2867"/>
            <end position="2950"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="21">
        <location>
            <begin position="3037"/>
            <end position="3299"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="20">
        <location>
            <begin position="3313"/>
            <end position="3645"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="22">
        <location>
            <begin position="3674"/>
            <end position="3894"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="16">
        <location>
            <begin position="4146"/>
            <end position="4257"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="4292"/>
            <end position="4436"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="4443"/>
            <end position="4753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3528"/>
            <end position="3598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3842"/>
            <end position="3904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="AYU79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4757" mass="544156" checksum="41D8A011E1D94922" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY40</accession>
    <name>A0A3S7WY40_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat and coiled-coil domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_240009800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0610"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000148">
        <property type="entry name" value="Leucine rich repeat and coiled-coil centrosomal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002006">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="14">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="14">
        <location>
            <begin position="1357"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="14">
        <location>
            <begin position="1645"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1767"/>
            <end position="1786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1786" mass="192812" checksum="89300561E6C9F534" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYW8</accession>
    <accession>E9BHB6</accession>
    <name>A0A3S7WYW8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="5">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_27175</name>
        <name evidence="10" type="ORF">CGC21_8165</name>
        <name evidence="9" type="ORF">LDBPK_250120</name>
        <name evidence="7" type="ORF">LdCL_250006300</name>
        <name evidence="8" type="ORF">LDHU3_25.0180</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP49016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861343.1">
        <property type="nucleotide sequence ID" value="XM_003861295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYW8"/>
    <dbReference type="SMR" id="A0A3S7WYW8"/>
    <dbReference type="GeneID" id="13391512"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0180"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP40635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP49016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="258" mass="28290" checksum="07EA7D4A6ABC191D" modified="2019-05-08" version="1">MFRTIPNYLKVAVCVKRVVDYTVKVRVKDNKVQTANSKMSVNPFDEIAIEEAIQLKEKKIADEVVAITIGGKKAEEVLRTAMALGCDKAVHVVIPDTAVDSVEPLAVAQILQKLHEEIMPDIWVLGKQAVDGDFGCTPQLLAGLLDVPQGTFASKVEVKDKKVTVTREVDAGRQVVELSMPCVLAADLRLNTPRFPKLPNIMKARKKPIDTKDVKALGVDITPRLSTETVTEPAARKAGVKVKTVDEFYDKLHAAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X073</accession>
    <accession>E9BIQ2</accession>
    <name>A0A3S7X073_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Primase zinc finger family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Primase zinc finger/Mcm10 replication factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_32480</name>
        <name evidence="5" type="ORF">LDBPK_262410</name>
        <name evidence="4" type="ORF">LdCL_260029800</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861826.1">
        <property type="nucleotide sequence ID" value="XM_003861778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X073"/>
    <dbReference type="SMR" id="A0A3S7X073"/>
    <dbReference type="GeneID" id="13389073"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3130"/>
    <dbReference type="OMA" id="RCHEASF"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP41265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="925" mass="97221" checksum="1ACAA8A0D2175797" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X221</accession>
    <name>A0A3S7X221_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_290007900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X221"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0410"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36475" checksum="E19947056FC4AD12" modified="2019-05-08" version="1">MEAPNYGRTGLLTSRLGGLPVTRPRLLLPGSSAAPRSVKWYPSLLTIPQQLLDALRREDDTEAADSDVPGTTTSFSSDPTLITYLRVATIAECLVQWWRRWAVAAAPKRTTEAVALTGPSREQLSALYTGILQWHRDELVSGKTVPSSALAHGSSSSSTFFIPAYKLLVMKHDRKVAEYANITWRSVWLLGKDPDVNDVPLEHPSCSGQHASMEMRFVLADEAALDAYVTEEVKALSPDAPMLSSPGADVPPFAQSTQALRSLCTGMWAMLEEALTSAGGDAAAVWTAELQLIDLGSTNHTKLNGEAVPAMEATTVIDSDVLEFGCSTRKYVVMRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X238</accession>
    <name>A0A3S7X238_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_290005500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X238"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0080"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="396" mass="45413" checksum="7CDCA5A7DD19719D" modified="2019-05-08" version="1">MEDPAAQEVVVTPWTVEGDVNYDKLIKHFGCQAIDEKLLERMERLTRKKPHHFLRRGIFFSHRDLNLILDAYEKGQPFYLYTGRGPSSESMHVGHLIPFMFTKWLQDSFHVPLVIQLTDDEKFFFKDLTMDEIDKMTTENLKDIIAFGFDPKLTFIFRDFEYVGRMYRIVARIEKAYTASQVRGCFGFKMEDNCGRWMFPAIQAAPSFSAAFPHIFPQEKGNVFCMIPQAIDQDPYFRLTRDVAPRMGYLKPAVIHSKFFPGLSGSKGKMSSSTGAAVFLTDTPKMIKDKINKHAFSGGGADKKEQLLLGGNTNVDVPMQWLRFFLEDDEELKRLQKDYMLGRIMTGDVKKVLIQQITSIVTAHQEARKKVTEADVELFTAVRAMGPAKEEAESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2B9</accession>
    <name>A0A3S7X2B9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Etoposide-induced protein 2.4 (EI24), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_290017900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2B9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1760"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="597" mass="64113" checksum="4CE6B2D5948650DA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2F1</accession>
    <name>A0A3S7X2F1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine/threonine-protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_290019300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2F1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1930"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="263"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="587" mass="61925" checksum="5D610F81B3ECA6AD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2I7</accession>
    <accession>E9BKX9</accession>
    <name>A0A3S7X2I7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase superfamily, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Thioesterase_superfamily_putative/Pfam:PF03061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_291820</name>
        <name evidence="3" type="ORF">LdCL_290023700</name>
        <name evidence="4" type="ORF">LDHU3_29.2620</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862600.1">
        <property type="nucleotide sequence ID" value="XM_003862552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2I7"/>
    <dbReference type="SMR" id="A0A3S7X2I7"/>
    <dbReference type="GeneID" id="13387336"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2620"/>
    <dbReference type="OMA" id="GVTNTMF"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000116">
        <property type="entry name" value="Thioesterase superfamily, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000136">
        <property type="entry name" value="Thioesterase superfamily, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF24">
        <property type="entry name" value="CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="189"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39512" checksum="0521E8C50C6E43F5" modified="2019-05-08" version="1">MMDPIHVSWTDIAGSDTTPGARLAAGRVLSMLDMCAARTSQKAVDHQACLTHERYLTCTVGVTDTIFSSPILHGDAVRLDSRLVHCGSSSMGIYIRFYRQSPSTRTETPAGHSFFTMVAITPDLKAAKVVPAIELTDPFDIELHNHYVKVRKLQEENKKNTAERLKRTLTTEEVQCSINQQKPTHARINSTKVEANRIFFTSCMNNNNTVFGGELMAWMEQHAVHCGRTFTANRHVFTIGMHSVAFPEPVFATDWVTLEATVIYVRNTTMEVDVVLKAERKDTSTVITNRASFVLINNDDIGRKCTIPVGLELNGATQEELQQFMEARVRYRCSVARRDDLHASNLCTGMTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2U2</accession>
    <accession>E9BL86</accession>
    <name>A0A3S7X2U2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial carrier family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Mitochondrial_carrier_protein-like_protein/GeneDB:LmjF.29.2780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_24680</name>
        <name evidence="15" type="ORF">CGC21_28920</name>
        <name evidence="13" type="ORF">LDBPK_292890</name>
        <name evidence="11" type="ORF">LdCL_290035000</name>
        <name evidence="12" type="ORF">LDHU3_29.4210</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5432006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862707.1">
        <property type="nucleotide sequence ID" value="XM_003862659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2U2"/>
    <dbReference type="SMR" id="A0A3S7X2U2"/>
    <dbReference type="GeneID" id="13385410"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290035000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4210"/>
    <dbReference type="OMA" id="AYECSKE"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000254">
        <property type="entry name" value="Mitochondrial carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="201"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5432006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP50623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP52909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="291" mass="31528" checksum="D44747A60E7BFCF5" modified="2019-05-08" version="1">MSDSTSPTTSAAQHGTLQFSLEELAAGGIAGFAEHFVMFPCDTIKTRMQGGGALSIGHVVRHLWNHERLTHLYRGCVPVLVSAIPAHGAYFGVYEALKRLFGDDTNMGIAAAASFSTAAHDTVSTPFDVIKQRMQMDKQRCFSSSVDCARRIVRTEGVGALFASLPTTVIMNIPHFSAYWLAYEGFLASRGHGNVRNRHDEMTVDYMAAGFVAGTCAAVVSFPFDTVKTHLQLGHGMGFRHTLSELIQLRGMRGVYSGVVPRILYTAPSGAIMMVTYETVKSALASDKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Y0</accession>
    <accession>E9BL90</accession>
    <name>A0A3S7X2Y0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_24655</name>
        <name evidence="6" type="ORF">CGC21_28945</name>
        <name evidence="4" type="ORF">LDBPK_292930</name>
        <name evidence="2" type="ORF">LdCL_290035400</name>
        <name evidence="3" type="ORF">LDHU3_29.4270</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5432010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862711.1">
        <property type="nucleotide sequence ID" value="XM_003862663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Y0"/>
    <dbReference type="GeneID" id="13385414"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290035400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4270"/>
    <dbReference type="OMA" id="LDYNCAV"/>
    <dbReference type="OrthoDB" id="277654at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="244" mass="27868" checksum="FD1F55BAC978EB91" modified="2019-05-08" version="1">MPRLLHGSQRAGEEHEAEKLTKPVPKIASDLAAQSLANLWRRLFQSYVHFTQPGCLPFVADAATYSDGVGNVADSDTALDALWAAGFGASSTPDALIVHLFLANKHFDAVSWIIAFCLVDRLQLSHYVRQRLRELSFLQQREDDSNCFLRLAREHVTQLLFTAYSLAFKWHLDYTVSVKYLTNLLPHTRSARVRILRSTIREELVVLETLEFNCAVSHDHLLQLMDHFLTASERRYVLQVIHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3F3</accession>
    <name>A0A3S7X3F3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300025100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3F3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2710"/>
    <dbReference type="OrthoDB" id="265681at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="327" mass="36496" checksum="330A46DCFA4E4EBC" modified="2019-05-08" version="1">MQRGHRCTDQLLLTRRLRRLFARVHERQWLLHHHQSDASLSWFHASSRPLQALHHLRSLQTNLSKLAWAPASFAEEADGDSPQTKLEDRPRDRAPPHPAAPPGDPPPFAHPAAPHLSFLMNASFLHETCLFLLLLRNPLPSSSLARLSSLSEREPLQVHSHGTVAAETTHYILQNGLWCSCLPHSVEATWLRAATPAIDVQLELGSSTDPTTRHDQAPDDSLDERGDAREAALARLCSHDYLEHLIWPTHAAGAVRPELAADCVWVDVSSVRSHALHSYNDAFWVPFSTSHSFAAWHRASLRATLDGQHAAASVEAWRWTGDLYICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3R8</accession>
    <name>A0A3S7X3R8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_300036500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4100"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001272">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1170"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1200"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1282"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1374"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1409"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1561"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1524"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1853"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1873"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1900" mass="210115" checksum="A746737282576AE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4A8</accession>
    <name>A0A3S7X4A8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310017200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4A8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1770"/>
    <dbReference type="OrthoDB" id="272966at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF136">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="55"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="542" mass="59422" checksum="A02EE8B83A58C451" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7D5</accession>
    <name>A0A3S7X7D5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_340005400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7D5"/>
    <dbReference type="SMR" id="A0A3S7X7D5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0050"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13985">
        <property type="entry name" value="STKc_GAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001636">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="340" mass="38313" checksum="7B84BC844BB0D4CB" modified="2019-05-08" version="1">MGNYFSLCPEPFHGLISSYGIGSTSSTHPSGVAVKGQEYSAVKLVGEGGYSFVYEGYNNASGQRVALKRYVFSETQQQQGAVEEMSIYRDVCPNDYIVTYLDSEVVYRHGVPLPEMWVVMEFCDGPSLQEYINNRLRSPQPFSVREVFEIVDNIVHAIGHLHSQSPPVSHWDIKPENFLFTDTGRLKLCDFGSATRQFYAPTSAEEVSAAESELGSRMTLLYRPPESLDLWSKDRVDTKADIWALGVIIYVLVFREMPFDANPMEVMAAVPKRYKGKTQEGCPEEFRALMDIVRTKMLTKKPADRADIFAISEELEGITHLPPLSRPRPGFQSAQRPRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7Q4</accession>
    <name>A0A3S7X7Q4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">R3H-associated N-terminal domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">R3H-associated_N-inal_domain_containing_protein_p utative/Pfam:PF13902</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340021800</name>
        <name evidence="4" type="ORF">LDHU3_34.2380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7Q4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2380"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="522" mass="58328" checksum="D39E3E638C47C5FA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8I2</accession>
    <accession>E9BRJ1</accession>
    <name>A0A3S7X8I2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_20555</name>
        <name evidence="3" type="ORF">LDBPK_343930</name>
        <name evidence="1" type="ORF">LdCL_340048700</name>
        <name evidence="2" type="ORF">LDHU3_34.6240</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864552.1">
        <property type="nucleotide sequence ID" value="XM_003864504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8I2"/>
    <dbReference type="GeneID" id="13387431"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340048700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6240"/>
    <dbReference type="OMA" id="HYYQEVG"/>
    <dbReference type="OrthoDB" id="277330at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5433990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="308" mass="35229" checksum="05E01BAC2A9D8391" modified="2019-05-08" version="1">MTSWKDRIAAMLFFRDPEEALTAEKMRNAEAMAKTTEVRLQHNQDEREVKEKMLQLENGIKAQRERYARQAAPMLKEFDDIAISQHYYQEVGNSVAAQETFVDQMAQRETHQFGYISKKLISVSLNFEALRQQMRSGKPFARELKATLDDAESEDLNAMSEPLRAFADRGVPESTLVRAAAFDLARSIEETGKAPVQQPVLGWLDLLKFRTAFSPSTVDQNEVRARRTAAQFTRYIEQRQYARALALAEEVDTWTRNEHDAAVEYFNNSYRSFRQATLPVITAEIFLAYAAASLNASRVACVEHMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8N7</accession>
    <name>A0A3S7X8N7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-ase activating protein, putative</fullName>
            <ecNumber evidence="4">3.6.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_350007600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.5.1" evidence="4"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8N7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0350"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044518">
        <property type="entry name" value="ARF_GAP_AGD11/12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46220:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="313"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="626" mass="69372" checksum="4F2A1B556653AE4F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X972</accession>
    <name>A0A3S7X972_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_0045</name>
        <name evidence="12" type="ORF">CGC20_21895</name>
        <name evidence="10" type="ORF">CGC21_6520</name>
        <name evidence="7" type="ORF">LdCL_350025200</name>
        <name evidence="8" type="ORF">LDHU3_21.2560</name>
        <name evidence="9" type="ORF">LDHU3_35.2610</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X972"/>
    <dbReference type="SMR" id="A0A3S7X972"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2610"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000004">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP44471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP46351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP54586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="249" mass="28276" checksum="54020868375AC7CC" modified="2019-05-08" version="1">MKLNIAYPRNGTVKQFEISDEVLRRVQLQDYRLGNEVDGAIFGSEFKGYIFRLRGGSDKDGFPMVPGVLASSRVSLLVKRGAIGFNTFRGYQGERRRKNVRGCVLASDIALVNVTISKVGDQPIEGVTDTTAPRRLGPKRASKIRKLFNLSRTEDVRKYVVRRRVVKSGKKDRLKAPKIQRLITPRVKARRAKKAKDAIAKVRASAAERREYLRLIASNRRALRQRDHSKKHTQKVHAQRAEVAAFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAI5</accession>
    <accession>E9BTH1</accession>
    <name>A0A3S7XAI5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA editing complex protein MP61</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RNA_editing_complex_protein_MP61/GeneDB:LmjF.36.1 050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_29370</name>
        <name evidence="4" type="ORF">LDBPK_361110</name>
        <name evidence="2" type="ORF">LdCL_360016200</name>
        <name evidence="3" type="ORF">LDHU3_36.1450</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865228.1">
        <property type="nucleotide sequence ID" value="XM_003865180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAI5"/>
    <dbReference type="GeneID" id="13388113"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1450"/>
    <dbReference type="OMA" id="ELIEMWW"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23726">
        <property type="entry name" value="ZF_RNaseIII_KREN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000021">
        <property type="entry name" value="RNA editing complex protein MP67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39671">
        <property type="entry name" value="COMPLEX PROTEIN NUCLEASE, PUTATIVE KREPB1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39671:SF3">
        <property type="entry name" value="RNA EDITING COMPLEX PROTEIN MP61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="228"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="587" mass="65390" checksum="839E8B2D845B3171" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJB9</accession>
    <accession>E9B7D1</accession>
    <name>A0A451EJB9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Insulinase (Peptidase M16) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Metallo-peptidase, Clan ME, Family M16</fullName>
            <ecNumber evidence="12">3.4.24.64</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Mitochondrial processing peptide beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC21_17790</name>
        <name evidence="13" type="ORF">LDBPK_010670</name>
        <name evidence="12" type="ORF">LdCL_010011700</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="12"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000041">
        <property type="protein sequence ID" value="TPP54516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857880.1">
        <property type="nucleotide sequence ID" value="XM_003857832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJB9"/>
    <dbReference type="GeneID" id="13389760"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0750"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000076">
        <property type="entry name" value="Mitochondrial processing peptide beta subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU75578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ31154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP54516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="494" mass="54988" checksum="D0D5DAB412553FB8" modified="2019-05-08" version="1">MMRRTGAVAATAALPQNMTMKDPLCQQVLSRCTPVVYSSLPNGFRVATEYVKDCPFATVGVWIDAGSRFEDIHNSGVAHFLEHMNFKGTDRYSKSDVENLFEHRGAHFNAYTSRDRTAYYVKAFTKDVDKMIDVVSDLLQRGRYRRHDIEAERPTILAEMREVEELVDEVLMDNVHQAAYDPTTSGLPLTILGPVENIAKNINKSMIEDYVRVHYTGPRMCLVSSGGISPDAAHALAEKYFSGLSSTNNRPLLRGAYKGGHTVLWNEGMATANTAVAFPICGASHPDSYPLQLIHNVIGQFREGQYDQFSSQRRNPNLPWERVPNLVQLRPFYTPYEETALLGYHIVTARMATSGIARDDAQTLMLNYVLSSLYDLCATKVDDSLLEAAKAEFKASVMMMRDSTTNSAEDLGRQMIHFGRRVPLQEVFERVDAVTPESLRAAAEKYLAVVQPTVSCIGASSTLPKYSPLSLVSNVVHPQLTSAQFPEDARACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJG9</accession>
    <accession>E9B7H6</accession>
    <name>A0A451EJG9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3' exoribonuclease family, domain 1 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNase PH-like protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ribosomal RNA processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_37170</name>
        <name evidence="10" type="ORF">CGC21_29960</name>
        <name evidence="9" type="ORF">LDBPK_020290</name>
        <name evidence="8" type="ORF">LdCL_020008300</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000040">
        <property type="protein sequence ID" value="TPP43094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000062">
        <property type="protein sequence ID" value="TPP43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857925.1">
        <property type="nucleotide sequence ID" value="XM_003857877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJG9"/>
    <dbReference type="GeneID" id="13390059"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0400"/>
    <dbReference type="OMA" id="TCIVQVR"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000076">
        <property type="entry name" value="Putative ribosomal RNA processing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP43094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="324" mass="33698" checksum="47CC259C059B6773" modified="2019-05-08" version="1">MAVVYARRDGRTALELRGKEMRLSDMTAFDGSSWYAQGQTAVMASIHGPTVAKNDEYDTCIVQVRVQHAGVLAPAAGGAEKVLYEERKLEVLTRTDALALGSLLESTLNAVFIRERFPRCVLVVDVVVVRDDGSLPAVALNAVMSALLDAGLPCRTTMAAVCVAVVTHDGGADSTSGPTQDRHSSVDGSSSAGSVYEYLLDPTSAEESLGVGYAAPAPSAAEKAVVTGASSVATSSAVPMPLRGRNAAQSVQDQHRCVSIGVFAFSNPACGGGLLAQLVRSVGSGSAEMRGPGVPVQAYAEMVALAERASAVLFEFFRQCNVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9V7</accession>
    <accession>A0A3S5H6D7</accession>
    <name>E9B9V7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zeta toxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_090700</name>
        <name evidence="5" type="ORF">LdCL_090012100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858750.1">
        <property type="nucleotide sequence ID" value="XM_003858702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9V7"/>
    <dbReference type="GeneID" id="13392098"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0840"/>
    <dbReference type="OMA" id="LLCCGIK"/>
    <dbReference type="OrthoDB" id="10263927at2759"/>
    <dbReference type="PhylomeDB" id="E9B9V7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF3">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="4">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="640" mass="68451" checksum="7FD9EE3887278ADA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9Y1</accession>
    <accession>A0A3S7WQQ6</accession>
    <name>E9B9Y1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phospholipid transporting ATPase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_090940</name>
        <name evidence="12" type="ORF">LdCL_090014800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858774.1">
        <property type="nucleotide sequence ID" value="XM_003858726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13392111"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1090"/>
    <dbReference type="OMA" id="FWWRYLT"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="PhylomeDB" id="E9B9Y1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000147">
        <property type="entry name" value="Phospholipid transporting ATPase-like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000190">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF51">
        <property type="entry name" value="ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2318"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2346"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2380"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2428"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="11">
        <location>
            <begin position="2204"/>
            <end position="2455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1453"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1638"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1709"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1996"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2501"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2082"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1996"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2015"/>
            <end position="2031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU76534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2528" mass="271905" checksum="3E693A37BD89C8FA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAE3</accession>
    <accession>A0A3S7WRA3</accession>
    <name>E9BAE3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_100990</name>
        <name evidence="2" type="ORF">LdCL_100016600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858934.1">
        <property type="nucleotide sequence ID" value="XM_003858886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAE3"/>
    <dbReference type="GeneID" id="13389303"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100016600"/>
    <dbReference type="OMA" id="EINETVW"/>
    <dbReference type="OrthoDB" id="273843at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="351" mass="39106" checksum="C41B6D454C9896F6" modified="2011-04-05" version="1">MAAVLPRPSQHVALQKRNHRSVGRPRPRHISREKSAAPKQRERTRTEALQVRPASDPLHCPSQLPPARRRRRCRCIGTDLRLRTACAAATRRAHPQRAGRSVSGVAHPLQSLLSALGLLWLSHAQPLQAEDSRFGAPPPALALASRGISTPSRRLSHFSYVCVPAVLELSDQRRAIFIAASSASAVRDVTGERPTSGTQFRHGSADRRRRWWLSGRTPPPTGALCGRRQPGVRPQRHLRNSPSLHSQVHSVAPADPLGQQFRCLCPLRERLKELHWEHCEQLTAVQHYIDCEINETVWRDGYDNAITDEYAVRELCGMGFKNNCTVVVGQGTVRLEGCDAAAVSEDAMQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCQ0</accession>
    <accession>A0A3S7WTT8</accession>
    <name>E9BCQ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_160460</name>
        <name evidence="3" type="ORF">LdCL_160009500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859734.1">
        <property type="nucleotide sequence ID" value="XM_003859686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCQ0"/>
    <dbReference type="GeneID" id="13393100"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0540"/>
    <dbReference type="OMA" id="VHARHFS"/>
    <dbReference type="OrthoDB" id="271832at2759"/>
    <dbReference type="PhylomeDB" id="E9BCQ0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="234" mass="25695" checksum="F8FB8F11E178CD9F" modified="2011-04-05" version="1">MTPRPSSTSGRGSSSDIGSGWALPKQIASWYPRKGGEFLANTIAGHNAFIQDIPTRFDEVHARHFSLVEGLAITPLYTLAMVHYFSIFCQYPARIAVLKPILEELRQKSELQHHWLLIMQAKRAPGEIIAWRCGILTLQVVLFPIWLFLSSAAPQLVHATVAFSNHILHTKYSCLKASGSSAASGRAAVVPEFVSKAADMYAATETFHEAQSVTLPTDFGVAIVMLLLILFFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD01</accession>
    <accession>A0A3Q8IJ71</accession>
    <name>E9BD01_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_161490</name>
        <name evidence="12" type="ORF">LdCL_160019900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859834.1">
        <property type="nucleotide sequence ID" value="XM_003859786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD01"/>
    <dbReference type="GeneID" id="13393157"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1770"/>
    <dbReference type="OMA" id="REEHAWE"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="PhylomeDB" id="E9BD01"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="320"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="522" mass="59061" checksum="1E8B1D36B28E7411" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD55</accession>
    <accession>A0A3S7WUA7</accession>
    <name>E9BD55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_170340</name>
        <name evidence="7" type="ORF">LdCL_170008900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859888.1">
        <property type="nucleotide sequence ID" value="XM_003859840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD55"/>
    <dbReference type="SMR" id="E9BD55"/>
    <dbReference type="GeneID" id="13393305"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0610"/>
    <dbReference type="OMA" id="QFHYPCA"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="PhylomeDB" id="E9BD55"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF4">
        <property type="entry name" value="PROTEIN NCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="725" mass="77166" checksum="F075319813D04354" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BED0</accession>
    <accession>A0A3Q8IBI1</accession>
    <name>E9BED0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_191410</name>
        <name evidence="3" type="ORF">LdCL_190019800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860313.1">
        <property type="nucleotide sequence ID" value="XM_003860265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BED0"/>
    <dbReference type="GeneID" id="13386125"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1700"/>
    <dbReference type="OMA" id="HTFDTQG"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="PhylomeDB" id="E9BED0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="81058" checksum="7135DEA9CB0879F6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEI7</accession>
    <accession>A0A3Q8IBI9</accession>
    <name>E9BEI7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar (And other) transporter/Major Facilitator Superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_200400</name>
        <name evidence="7" type="ORF">LdCL_200008700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860380.1">
        <property type="nucleotide sequence ID" value="XM_003860332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEI7"/>
    <dbReference type="GeneID" id="13386303"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0460"/>
    <dbReference type="OMA" id="ISMGSVW"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="PhylomeDB" id="E9BEI7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17334">
        <property type="entry name" value="MFS_SLC49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="732" mass="78952" checksum="65371BC9607DBE4E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHI6</accession>
    <accession>A0A3S5H7E4</accession>
    <name>E9BHI6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_250820</name>
        <name evidence="3" type="ORF">LdCL_250013500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861412.1">
        <property type="nucleotide sequence ID" value="XM_003861364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHI6"/>
    <dbReference type="GeneID" id="13388658"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1030"/>
    <dbReference type="OMA" id="NWSMCAP"/>
    <dbReference type="OrthoDB" id="263306at2759"/>
    <dbReference type="PhylomeDB" id="E9BHI6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1168" mass="124371" checksum="5EE92BCFF84688D6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIC2</accession>
    <accession>A0A3S7WZS2</accession>
    <name>E9BIC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Axonemal dynein light chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_261100</name>
        <name evidence="4" type="ORF">LdCL_260016600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861697.1">
        <property type="nucleotide sequence ID" value="XM_003861649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIC2"/>
    <dbReference type="GeneID" id="13388943"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1380"/>
    <dbReference type="OMA" id="ATQNAYL"/>
    <dbReference type="OrthoDB" id="277800at2759"/>
    <dbReference type="PhylomeDB" id="E9BIC2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF2">
        <property type="entry name" value="ARM LIGHT CHAIN, AXONEMAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="354"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="466" mass="49994" checksum="D1C8D87BD1E84E98" modified="2011-04-05" version="1">MAVPEGRSIYEVLGTVLYRTVPVNIDDANVQRKQQQQWDDFNVPLDYDTALALREIDEATMAARYLATKARGAASATAGGATSRDGAMVADRVSSATTTRASAAATSTVPVPPQRSSTPSFTSALHGGSGSGGGQLSAAKTSQCALRFGSPSENSLATNFRSSVEVAGGQRNASEAVDIATQNAYLVKARMNAAAAAKSTGSGTGVVPAAARSSRDGIGAMTVAQAMEILFPVEAVGYGGGSREDSAKDGEEKASDGAPTPPLSASTSRVLSSATAAAARSAASTPVMWRRADVAHLSRLDVVLLYKHLERRCACESARPRGVVCPNRECIYNDGLRELIRQVTLLCPERGLLLDELARRMRQAIETYDVLLDSANQYAVRKSTERDLHQYLFAEKTDLETEVRRREHRVNEWRAKYAGLQKRFQEQQEADRKLHAEEIAYAKRANQQLVSEIKRLASEAGKAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJI8</accession>
    <accession>A0A3Q8IAY3</accession>
    <name>E9BJI8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_281170</name>
        <name evidence="2" type="ORF">LdCL_280016300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862216.1">
        <property type="nucleotide sequence ID" value="XM_003862168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJI8"/>
    <dbReference type="GeneID" id="13386952"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1450"/>
    <dbReference type="OMA" id="FIRYCCR"/>
    <dbReference type="OrthoDB" id="277701at2759"/>
    <dbReference type="PhylomeDB" id="E9BJI8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="722" mass="81122" checksum="97CC042A08723333" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9BM12</accession>
    <accession>A0A3Q8IG02</accession>
    <name>E9BM12_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_302690</name>
        <name evidence="5" type="ORF">LdCL_300032500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862980.1">
        <property type="nucleotide sequence ID" value="XM_003862932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BM12"/>
    <dbReference type="GeneID" id="13385689"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300032500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3610"/>
    <dbReference type="OMA" id="MKNEVYF"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="PhylomeDB" id="E9BM12"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31576" checksum="3BB42336060A9DE6" modified="2011-04-05" version="1">MRYFVVAHEFQAEEDVELSVFKGEILCATEGIAQDGWIKVEVTMDARRRGFVPISYLREISAAEASASMPAPASSAPPSAGESTSPMRTPQRAGGESPARAALANTTISTSLNLGNCSDVVKKGSSPSLQPMRSPETAAAHAAPTSSSIHLTPAQQAAGPVNRHLLENPNAVVDAFMKNEVYFNQLMQRRASALAQMQSGLEEAMTEVAACKDRSAVLTRKLHDLDGVVERERQRWMDRVEEEKAHVSRSAPYSAPLAVPVSCGTTPVRSPIIGPRSGLGRSVLDDDSPRQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BP42</accession>
    <accession>A0A3S7X5W9</accession>
    <name>E9BP42_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_322910</name>
        <name evidence="2" type="ORF">LdCL_320035100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863704.1">
        <property type="nucleotide sequence ID" value="XM_003863656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BP42"/>
    <dbReference type="GeneID" id="13391229"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320035100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3690"/>
    <dbReference type="OMA" id="IFWEAEY"/>
    <dbReference type="OrthoDB" id="267839at2759"/>
    <dbReference type="PhylomeDB" id="E9BP42"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="956" mass="98415" checksum="AA4BE49D5476281A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPV3</accession>
    <accession>A0A3S7X6D2</accession>
    <name>E9BPV3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_330240</name>
        <name evidence="10" type="ORF">LdCL_330007300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863848.1">
        <property type="nucleotide sequence ID" value="XM_003863800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPV3"/>
    <dbReference type="GeneID" id="13392245"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0280"/>
    <dbReference type="OMA" id="RCNCCIL"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="PhylomeDB" id="E9BPV3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ37165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="572" mass="63902" checksum="D2475913FD8C91F1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUB4</accession>
    <accession>A0A3S7XBE3</accession>
    <name>E9BUB4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_364060</name>
        <name evidence="2" type="ORF">LdCL_360047600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865520.1">
        <property type="nucleotide sequence ID" value="XM_003865472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUB4"/>
    <dbReference type="GeneID" id="13388406"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360047600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5450"/>
    <dbReference type="OMA" id="AQCQAHR"/>
    <dbReference type="OrthoDB" id="251871at2759"/>
    <dbReference type="PhylomeDB" id="E9BUB4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001420">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110:SF3">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="841" mass="87838" checksum="2E726EFC609C09BC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-04-18" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H6V7N3</accession>
    <accession>E9BQG1</accession>
    <name>H6V7N3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c peroxidase, mitochondrial</fullName>
            <ecNumber evidence="10">1.11.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">APx</name>
        <name evidence="18" type="ORF">LDBPK_340070</name>
        <name evidence="16" type="ORF">LdCL_340005800</name>
        <name evidence="17" type="ORF">LDHU3_34.0100</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2014" name="Antimicrob. Agents Chemother." volume="58" first="6172" last="6184">
            <title>Ascorbate Peroxidase, a Key Molecule Regulating Amphotericin B Resistance in Clinical Isolates of Leishmania donovani.</title>
            <authorList>
                <person name="Kumar A."/>
                <person name="Das S."/>
                <person name="Purkait B."/>
                <person name="Sardar A.H."/>
                <person name="Ghosh A.K."/>
                <person name="Dikhit M.R."/>
                <person name="Abhishek K."/>
                <person name="Das P."/>
            </authorList>
            <dbReference type="PubMed" id="25114128"/>
            <dbReference type="DOI" id="10.1128/AAC.02834-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 20" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JN802370">
        <property type="protein sequence ID" value="AFA46757.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864172.1">
        <property type="nucleotide sequence ID" value="XM_003864124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H6V7N3"/>
    <dbReference type="SMR" id="H6V7N3"/>
    <dbReference type="PeroxiBase" id="13530">
        <property type="entry name" value="LdonAPx-CcP01"/>
    </dbReference>
    <dbReference type="GeneID" id="13392581"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0100"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="BRENDA" id="1.11.1.11">
        <property type="organism ID" value="2947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000025">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="44"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFA46757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAC5433558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ37490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33711" checksum="D84D4256185CB291" modified="2012-04-18" version="1">MSGTSRRAKGLFTGIAVGTFVSGAMFVSCASARVEEPPFDIRALRADIESMISDKLELGPSLIRLAWHEAASYDCFKKDGSPNSASMRFKPECLYEGNKGLDIPRKALEPLKKKYPQISYADLWVLAAYVAIEYMGGPTIPFCWGRVDAKDGSVCGPDGRLPDGSKTQSHVREVFTRLGFNDQETVALIGAHTCGECHIKFSGYHGPWTHDKNGFDNSFFTQLLDEDWVLNPKVEKMQLMDRATTKLMMLPSDVSLLLDPGYRKYVELYAKDNDRFNKDFANAFKKLTELGTKNLHRAPASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q76LS6</accession>
    <accession>E9BK16</accession>
    <name>Q76LS6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Antigen LACK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_12715</name>
        <name evidence="16" type="ORF">CGC20_12720</name>
        <name evidence="17" type="ORF">CGC21_22865</name>
        <name evidence="18" type="ORF">CGC21_22870</name>
        <name evidence="14" type="ORF">LDBPK_282970</name>
        <name evidence="9" type="ORF">LdCL_280034500</name>
        <name evidence="10" type="ORF">LdCL_280034600</name>
        <name evidence="12" type="ORF">LDHU3_28.3930</name>
        <name evidence="13" type="ORF">LDHU3_28.3950</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="book" date="1998" name="Proceedings of the 10th International Cogress of Immunology 1" first="1099" last="1104" publisher="Unknown publisher">
            <title>Molecular cloning and expression of Leishmania homologue of receptors for activated C kinase (LACK) cDNA of Leishmania donovani.</title>
            <editorList>
                <person name="Unknown A."/>
            </editorList>
            <authorList>
                <person name="Matsumto Y."/>
                <person name="Takeuchi M."/>
                <person name="Matsumoto Y."/>
                <person name="Otsuka H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MHOM/CN/86/Sc-6</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2001" name="Infect. Immun." volume="69" first="4719" last="4725">
            <title>Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis.</title>
            <authorList>
                <person name="Melby P.C."/>
                <person name="Yang J."/>
                <person name="Zhao W."/>
                <person name="Perez L.E."/>
                <person name="Cheng J."/>
            </authorList>
            <dbReference type="PubMed" id="11447143"/>
            <dbReference type="DOI" id="10.1128/IAI.69.8.4719-4725.2001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">MHOM/SD/001S-2D</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2001-12" db="EMBL/GenBank/DDBJ databases">
            <title>Pretreatment of leishmania homologue of receptors for activated C kinase (LACK) promotes disease progression of leishmaniasis caused by leishmania amazonensis.</title>
            <authorList>
                <person name="Okuno T."/>
                <person name="Takeuchi M."/>
                <person name="Matsumoto Y."/>
                <person name="Otsuka H."/>
                <person name="Matsumto Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">MHOM/CN/86/Sc-6</strain>
        </source>
    </reference>
    <reference evidence="14 19" key="4">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 20" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="10">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="11">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF363974">
        <property type="protein sequence ID" value="AAK51527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB075696">
        <property type="protein sequence ID" value="BAB91559.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862394.1">
        <property type="nucleotide sequence ID" value="XM_003862346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q76LS6"/>
    <dbReference type="SMR" id="Q76LS6"/>
    <dbReference type="GeneID" id="13387130"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3950"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="238121at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000018">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAK51527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAB91559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5431675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5431676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP40359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP54414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP54415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="312" mass="34373" checksum="778321761BBCCD99" modified="2004-07-05" version="1">MNYEGHLKGHRGWVTSLACPQQAGSYIKVVSTSRDGTAISWKANPDRHSVDSDYGLPSHRLEGHTGFVSCVSLAHATDYALTASWDRSIRMWDLRNGQCQRKFLKHTKDVLAVAFSPDDRLIVSAGRDNVIRVWNVAGECMHEFLRDGHEDWVSSICFSPSLEHPIVVSGSWDNTIKVWNVNGGKCERTLKGHSNYVSTVTVSPDGSLCASGGKDGAALLWDLSTGEQLFKINVESPINQIAFSPNRFWMCVATERSLSVYDLESKAVIAELTPDGAKPSECISIAWSADGNTLYSGHKDNLIRVWSISDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A221LG88</accession>
    <accession>E9BV27</accession>
    <name>A0A221LG88_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Sec23</name>
        <name evidence="19" type="ORF">CGC21_15660</name>
        <name evidence="18" type="ORF">LDBPK_366710</name>
        <name evidence="17" type="ORF">LdCL_360075400</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="J. Biol. Chem." volume="292" first="12111" last="12125">
            <title>GTPase Sar1 regulates the trafficking and secretion of the virulence factor gp63 in Leishmania.</title>
            <authorList>
                <person name="Parashar S."/>
                <person name="Mukhopadhyay A."/>
            </authorList>
            <dbReference type="PubMed" id="28576830"/>
            <dbReference type="DOI" id="10.1074/jbc.M117.784033"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 21" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">COPII-coated vesicle membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KY484913">
        <property type="protein sequence ID" value="ASM94289.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865782.1">
        <property type="nucleotide sequence ID" value="XM_003865734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A221LG88"/>
    <dbReference type="SMR" id="A0A221LG88"/>
    <dbReference type="GeneID" id="13386636"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360075400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8920"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000070">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000043">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF33">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="229"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="488"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="603"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="717"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ASM94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ39106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP48782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="850" mass="94171" checksum="645BA27323B4FA06" modified="2017-10-25" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I959</accession>
    <accession>E9BAU9</accession>
    <name>A0A3Q8I959_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L28, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">60S_ribosomal_protein_L28_putative/GeneDB:LmjF.11.1110/GeneDB:LmjF.11.1130</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal L28e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_31100</name>
        <name evidence="11" type="ORF">CGC20_31110</name>
        <name evidence="12" type="ORF">CGC21_0695</name>
        <name evidence="13" type="ORF">CGC21_0705</name>
        <name evidence="9" type="ORF">LDBPK_111110</name>
        <name evidence="5" type="ORF">LdCL_110017100</name>
        <name evidence="6" type="ORF">LDHU3_11.1330</name>
        <name evidence="7" type="ORF">LDHU3_11.1350</name>
        <name evidence="8" type="ORF">LDHU3_11.1370</name>
    </gene>
    <organism evidence="5 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="20" key="6">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 2-141</scope>
    </reference>
    <reference evidence="5 15" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="10">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="11">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP52987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP52989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859086.1">
        <property type="nucleotide sequence ID" value="XM_003859038.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="Z=1-147"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="a=1-147"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="Z=2-141"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I959"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3Q8I959"/>
    <dbReference type="GeneID" id="13389859"/>
    <dbReference type="KEGG" id="ldo:LDBPK_111110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110017100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1370"/>
    <dbReference type="OMA" id="FNNNGSW"/>
    <dbReference type="OrthoDB" id="266190at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000007">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18 19 20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5428212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP39891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP39893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP52987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="147" mass="16371" checksum="4B5FC38240559876" modified="2019-04-10" version="1">MSHSVDLQWILVRQNSRFLQKRGGIRMSNDPFNNNGNWTKRHCGFLNEKAAVVKPAKGGAICVTVKDGSSNNKPRQTYRKTVHAAGVRASDVSRAVAAVRPDLADVSFRRARRMACIASRTAKVAAARKARSEKIKFSRKSVRAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAT2</accession>
    <name>A0A3Q8IAT2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210010500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAT2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0610"/>
    <dbReference type="OrthoDB" id="265595at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="551" mass="57092" checksum="476E7D4DA626EB11" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB40</accession>
    <name>A0A3Q8IB40_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_100018200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB40"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1480"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30954" checksum="A5079C02EDC7A4FF" modified="2019-04-10" version="1">MGEKEAVTCVCVCVRFCDSATRVDMLRHCPLHRCLPISVACRVLGFQAPPTSKHDLRKRFVQLTKECHPDLHAENEKAATAKMVQLTEAYTCLKKLLEHRVQYHQGAGLGPRPSSASASGEGSAAARPHEDVWAEVTASFRAPGSSISLRGFTLPWQRTTSNSVISSLEAKMREANVSFSDFVRYARHLEKDRQTKENRIRADAAMADGTHGFTAEYFESVNKNSAFRRATERRRLPMTHFMTLGAFYYGRRLRNGIEQAPRGAWRTLRYVVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBD2</accession>
    <accession>E9BGZ9</accession>
    <name>A0A3Q8IBD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle (TRAPP) component, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transport_protein_particle_(TRAPP)_component_puta tive/Pfam:PF04051</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_241360</name>
        <name evidence="2" type="ORF">LdCL_240018700</name>
        <name evidence="3" type="ORF">LDHU3_24.1640</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861227.1">
        <property type="nucleotide sequence ID" value="XM_003861179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBD2"/>
    <dbReference type="GeneID" id="13391149"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1640"/>
    <dbReference type="OMA" id="YMEEPVG"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12171" checksum="3702B8ACE021963D" modified="2019-04-10" version="1">MWKAIFGKKVDSIKAIDSIYHLSDNDFRWLQGFPQLKGQDRVQTLASSEGEGSKDGYTEEPVGPVSHRDVLLYTVGIIKGATHPLLGESSLAVTGTHTKEGETFFTLDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBH8</accession>
    <name>A0A3Q8IBH8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290020700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBH8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2210"/>
    <dbReference type="OrthoDB" id="267202at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="899" mass="94338" checksum="12A84A3B1052546E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBX3</accession>
    <name>A0A3Q8IBX3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_22725</name>
        <name evidence="16" type="ORF">CGC21_33860</name>
        <name evidence="14" type="ORF">LdCL_210007900</name>
        <name evidence="15" type="ORF">LDHU3_21.0320</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBX3"/>
    <dbReference type="SMR" id="A0A3Q8IBX3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0320"/>
    <dbReference type="OrthoDB" id="268883at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000156">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000010">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="231"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU78492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5429764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP49264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP54752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="471" mass="51763" checksum="4E16CD0E8C6653CE" modified="2019-04-10" version="1">MATRVNNLLSHIAIRDSDSEEMRYIKQRLALASLATQFTMSSEKMKQLTMYMIHEMVEGLEGRPSTVRMLPSFVYTSDPAKATGVYYALDLGGTNFRVLRVSLRGGKVDDRTDSKFVIPKSALVGDATDLFDFIAQSVKKMMSENAPDDLEKRVPLGFTFSFPVDQKAVNKGLLIKWTKGFSTKNVEGNDVVELLQASLRRVRVNVNVVALCNDTVGTLVARYFVDTDVQVGVIIGTGSNACYFERASAVTKDPAVSARGNAVTPINMECGNFDSKYKYALPITVYDDEMDAITPNRENQRQEKLVSGMYLGEISRRLIVHLAQLGCLPRGLVDGLCRPWAFESKHMGMIAADQMPGLQFTRELIKRIAGVDVTDMSDLHTIREACCLVRNRAAQQGAVFTAAPMLKTRTQGLATVAVDGSVYEKTPSFQRLYQECITSILGSTSNVKVVLQKDGSGVGAAMICALAVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC07</accession>
    <name>A0A3Q8IC07_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="4">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_6805</name>
        <name evidence="9" type="ORF">CGC21_35745</name>
        <name evidence="6" type="ORF">LdCL_300024400</name>
        <name evidence="7" type="ORF">LDHU3_30.2630</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC07"/>
    <dbReference type="SMR" id="A0A3Q8IC07"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2630"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5432215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP43327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP45758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="498" mass="53857" checksum="F4769F9E7CE4295E" modified="2019-04-10" version="1">MLRRTLFRFKPAILTAAEALQDVRDGATIALGGFGFCGFPFELLEALNQRGTKQLTLIAGTTSGPENGTGPLARDRQLKKIITSYVGENSVLSDRLFHGEFEIEFCPMGTLVDRLRAAGAGLPAFYTPTGYGTAVAEGRLPVRFAPGKAVRVAEYSQPRETRQFNGRWCTLEMALPADFAFVRAWKADKRGNLVFRGTTQNFNLASAKAAKVCIAEVEEIVECGELDPKTVHLPGVYVHRLVCPPNIRRAAEFVVERKPGFSTGTGKNAHAGRNLIARRAALEIKDGMTLNLGIGIPNMVASYIPPEMDVVLQGENGLLGIGPYPLPEEVDPDITNAGKQTVTMSKSGASLFDSAESFSMIRGGHLDLTMLGALEVSGTGDIASWWVPGKVLKGMGGAMDLVMSGCRIVVLMEHTDKEGKPRVVESCRVPLTGTGVVDLLITELCTFRFVKEKGGINEMWLSELSEGVTLEEVRAKTSAAFKVDPNLKTMPRVDPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC76</accession>
    <name>A0A3Q8IC76_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250008700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC76"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0430"/>
    <dbReference type="OrthoDB" id="441890at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1308" evidence="2">
        <location>
            <begin position="677"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="753" mass="81038" checksum="92AF79D2A0369E3F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC89</accession>
    <accession>E9BAH2</accession>
    <name>A0A3Q8IC89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Flagellar protofilament ribbon protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Flagellar_protofilament_ribbon_protein-like_prote in/GeneDB:LmjF.10.1190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_101280</name>
        <name evidence="11" type="ORF">LdCL_100019800</name>
        <name evidence="12" type="ORF">LDHU3_10.1640</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIB43A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858962.1">
        <property type="nucleotide sequence ID" value="XM_003858914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC89"/>
    <dbReference type="SMR" id="A0A3Q8IC89"/>
    <dbReference type="GeneID" id="13389477"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1640"/>
    <dbReference type="OMA" id="NLCRAIN"/>
    <dbReference type="OrthoDB" id="429119at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008805">
        <property type="entry name" value="RIB43A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517:SF6">
        <property type="entry name" value="RE41410P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517">
        <property type="entry name" value="RIB43A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05914">
        <property type="entry name" value="RIB43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5428086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="397" mass="47021" checksum="F2BF2BD88B46FB65" modified="2019-04-10" version="1">MGSAVEEQNLFSAANGRGIAAASSVDNAASASNQMNTKTKKQLFMLQRAERLKDPKVRKMGIDREALDAQVREKEALRRLEKERNDYYDRQALLMDRHACALQQEVNSIRAAREKELQDYRQTFQKKEMGREWDLNDPEARRKELPARIGDDDPRNGPSSLQKFEGEDLDYAARRAAQQRQQRQWAQQQVNEKLAKKWMEQERDRAFDDRNEEVNHRLYEVEQKVAEQRRLMEKNGADFNRALAEQQRREAVRAKEEDTRLGLQEMAYQMDSDFLNERETVVSELGGSVMAERYKGMSEKQKTLLRAGQDEQLRELRRRRLLEVEEQRQWSLQENMQLRMANALDRQRERERRAEREQLAETHKMQAQAAAKRKAQLDELYKNAVDEDYFKYWDRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICB5</accession>
    <name>A0A3Q8ICB5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_250005900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICB5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0120"/>
    <dbReference type="OrthoDB" id="272847at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9436" checksum="042A60D4868EB166" modified="2019-04-10" version="1">MFRRLSAIPVRWTAGAVSGVGTSAMASGPRAYAAKGEEQMDDAEFEFFEDDLWFLDELCDENVGDLFSYIPSSDATLLGHDEPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICB8</accession>
    <name>A0A3Q8ICB8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220013500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICB8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1050"/>
    <dbReference type="OrthoDB" id="276203at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23457" checksum="F553FB4F34B2EAF5" modified="2019-04-10" version="1">MRRPKTECEIQQEQSDELFARQLQEQLNNSGDVVHAPPPQSGPSKSVQEAADAAYARQLQQEIDRQEAATDAGDSRASEDKIPVECPACTFVNYMKPSSSSNHWKCAQCSRPLMENVSYSGHVSHKDLVECRVCHSLNKLPTKKSDAVLCGGCYQELGSTLSSVPHVESEENQRTVQLRCGQCSVINAVTVGVNVKRLEFICGGCGVLNTMTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDK0</accession>
    <name>A0A3Q8IDK0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_250026200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDK0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2510"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000078">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18858" checksum="78E7029DC6D2612A" modified="2019-04-10" version="1">MPPLLLSSLDSPITERSITKGKAALLAHAYTNTRELENRHTPLTALFIFTIEDAAAAVVNPMEASRYIYTYRIFVSGRVQGVFYRKYTALKATELGVTGFVRNLPDGRVEILAEGTKEQIGALEAWCHRGSPKAQVTAVDVEDCTQVVPPSGGAEAMAKPPMNRTMSGFVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDQ7</accession>
    <accession>E9BKU3</accession>
    <name>A0A3Q8IDQ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_093020</name>
        <name evidence="1" type="ORF">LdCL_290019700</name>
        <name evidence="2" type="ORF">LdCL_290019900</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862564.1">
        <property type="nucleotide sequence ID" value="XM_003862516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDQ7"/>
    <dbReference type="GeneID" id="13387301"/>
    <dbReference type="KEGG" id="ldo:LDBPK_093020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_093020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2100"/>
    <dbReference type="OMA" id="CWRVERM"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9114" checksum="4E069DCB2ADE651D" modified="2019-04-10" version="1">MHVKSAIASWSGNATWGPVMGTGEAELSAVRERMAARGPPGKLFHSAKLLGQVSWLRCCVRDPRGGEAAVLMLFSRCWRVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDX6</accession>
    <name>A0A3Q8IDX6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N6-adenine methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_170010200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDX6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0760"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF1">
        <property type="entry name" value="NUCLEIC ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="543" mass="60500" checksum="C0954D009EA7B680" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDY2</accession>
    <name>A0A3Q8IDY2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF-2B subunit epsilon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280029600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDY2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3320"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056818">
        <property type="entry name" value="GlmU/GlgC-like_hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24894">
        <property type="entry name" value="Hexapep_GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-1-phosphate adenylyltransferase/Bifunctional protein GlmU-like C-terminal hexapeptide" evidence="2">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="836" mass="90416" checksum="02847640CC402524" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDY7</accession>
    <name>A0A3Q8IDY7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_330033900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDY7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3800"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005425">
        <property type="entry name" value="PRK07006.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504:SF1">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="425" mass="46412" checksum="F8CAF152D4594F38" modified="2019-04-10" version="1">MAESIAFAKGALVVPSCPIIPYIEGDGIGKEITEVAHRVFDAAVAKEYGTTRRISWLEVLAGEKAFEQKGTWLPEETIEAFDKHRIGMKGPLTTPVGEGIRSLNVVLRHRLDLFVCQRPVRWFTGVGSPIRHPEWVDMVVFRENTEDIYSGIEWDQGTPEAAKFADFLKKEMGVTTVRFPETSAYGVKPVSLEGSERLVRAAVQYAIDHHLPSVTLVHKGNIMKFTEGGFKKWGYALAEREFPGAIFTMTQYDAIKEKSGKEAAETALREAMDSGKVVIKDCICDAFLQNTILRPLDYSVIATMNLNGDYVSDQLAALVGGIGIAPGANINYVTGHAIFEATHGTAPDIAGQGKANPSSLILSGAMMFDYMGWSEVSARIINALEMVFQANMATVDLARQMAGARALSTAEFGEAIIKKINGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEV7</accession>
    <name>A0A3Q8IEV7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_22290</name>
        <name evidence="2" type="ORF">LdCL_280021700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEV7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2190"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP54299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="103" mass="10575" checksum="F693DEEEEBD615BD" modified="2019-04-10" version="1">MAQLIGAGSTGSIPGIVSIQGWSKTSTEKQQAWIGGLVAAIVALVIVYGLVAVQLGHKPRYVNAAWPHLQNIGSYAELEATHASYEVSVASCSGNLSDPAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF59</accession>
    <accession>E9BHE4</accession>
    <name>A0A3Q8IF59_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_8285</name>
        <name evidence="4" type="ORF">LDBPK_250400</name>
        <name evidence="2" type="ORF">LdCL_250009100</name>
        <name evidence="3" type="ORF">LDHU3_25.0470</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861370.1">
        <property type="nucleotide sequence ID" value="XM_003861322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF59"/>
    <dbReference type="SMR" id="A0A3Q8IF59"/>
    <dbReference type="GeneID" id="13388617"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0470"/>
    <dbReference type="OMA" id="CYGMVDE"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="201" mass="21961" checksum="29EC8BE6619AB031" modified="2019-04-10" version="1">MGSLGGASYVVRVQQATTAADALAAVQSGLADASVFFYGALLSALQTCMRRQNATAVPARTSDTIALLKLLTFNTVADVDETSDGVKALLAQQPELMTKLQLLSFLTLCSEHALTPDGVCLSYDDVERALGVQDTVSVQRTVLHAVQQRLCVARLNERERQVRVYSYESRNVTPDDMAKLRERVAQWTAYAEAHLRDIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF70</accession>
    <name>A0A3Q8IF70_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350031400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF70"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3400"/>
    <dbReference type="OrthoDB" id="273907at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="243"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="326" mass="34905" checksum="CC3DF5C6F350F855" modified="2019-04-10" version="1">MKLEPRERRLRSDYILDNAAALQLGKLYLGWGRSKRRSKPKRATPAAVPKPKAAPVKASTKKTSKTAAAKSSPVSEKAARTAPRTPTKQVPTKPATRAPPVEKRPRGRPRKTTSPAAAIKSVPPKTRSRGRPATAPAKAPPKAATRDSVRPCKNPNPVVKSISSKVVAAATAAAAAVSASAKVPATPLPHTPRKTAKVLATKTVVQQHRRRANNKVPPVIPNPVPTPALLLGAAEQWVDRGDVTVLVRTMNGTSFRLACTSESTLWDLKRRILEVIMPWTASASPDSMVRLPMLVMNGRALGPETATLAALRFSAESTVYCFPEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF79</accession>
    <accession>E9BM94</accession>
    <name>A0A3Q8IF79_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_6100</name>
        <name evidence="8" type="ORF">CGC21_36445</name>
        <name evidence="6" type="ORF">LDBPK_303510</name>
        <name evidence="4" type="ORF">LdCL_300040700</name>
        <name evidence="5" type="ORF">LDHU3_30.4670</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863062.1">
        <property type="nucleotide sequence ID" value="XM_003863014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF79"/>
    <dbReference type="SMR" id="A0A3Q8IF79"/>
    <dbReference type="GeneID" id="13385771"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300040700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4670"/>
    <dbReference type="OMA" id="FQRICTR"/>
    <dbReference type="OrthoDB" id="423589at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001609">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="401" mass="44032" checksum="4D2D880EF5FC6A81" modified="2019-04-10" version="1">MAALAALEKEVADLKRVRVFNETVRTGVERVLASLPSPENEKDTSTKARILLLRSQATLLLPRVSREAEKDLNAALKLQPGSTTTWVELSECLLRRNAFKEACDALDNALRVNPAHTEALCKYSQIQRNRCGEEGVTAEQRKAYLEDAVAKARAAVGSNVDDADAWNTLALSLLSKVTLEGMTFDGVRKALAAMQQAERKCPEDPDVPYNKAVLESLLGHFGAAAMDYWKAHALDKDRLKGTRHLSEENAKVLLRAQSRMRTSSGIGKRDFQRIRTRIEQAHKKYTQSTSAKVVGVLDIVTEPTMQPVTLLVSDGKGDFGLLLLHEVRPTCFKIGDVIAYPVTTPVETITHNVVACPGVVEEPLKLTLNHAYPNPKGILVNGQPLPSSAHVPLQMSSRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF86</accession>
    <name>A0A3Q8IF86_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_210021700</name>
        <name evidence="2" type="ORF">LdCL_210022100</name>
        <name evidence="3" type="ORF">LdCL_210022400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF86"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210022400"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8313" checksum="95D2AAE2FEEC8729" modified="2019-04-10" version="1">MPSHSWWWWQGPVPATQRGQSNSALLMLSVKALRGAASTPPAQRAECEAGAVLSGDCIGALLDRRVSTAAMAPREVGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFL9</accession>
    <accession>E9BN98</accession>
    <name>A0A3Q8IFL9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein-associated protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Roadblock/LC7 domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_10665</name>
        <name evidence="4" type="ORF">LDBPK_313280</name>
        <name evidence="3" type="ORF">LdCL_310041100</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863412.1">
        <property type="nucleotide sequence ID" value="XM_003863364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFL9"/>
    <dbReference type="GeneID" id="13389984"/>
    <dbReference type="KEGG" id="ldo:LDBPK_313280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5540"/>
    <dbReference type="OMA" id="YFIMEPQ"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000042">
        <property type="entry name" value="Dynein-associated protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="123" mass="13690" checksum="A6CA19A18B19E9D1" modified="2019-04-10" version="1">MNKANPSAAEREAHLQNVEDTLNRIAHHKGVLGYFIMEPQKGKLLSFAGFRGSSREAHRYADTLKGFIDLTTSTVRTIDWKDEMTFLRISCDTVDILVAPDANKEYTMVVVQTVKGRCAGGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFR1</accession>
    <name>A0A3Q8IFR1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_340036600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFR1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4860"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001706">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="308"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="835"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="941" mass="100071" checksum="259876B5A52E0630" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG53</accession>
    <name>A0A3Q8IG53_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_320020300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1850"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001143">
        <property type="entry name" value="DEAD/DEAH box helicase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="306"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="926"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1204"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1347"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1632"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1244"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1689" mass="184825" checksum="B542AD5247DE2529" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG93</accession>
    <name>A0A3Q8IG93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240025300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG93"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2400"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF126">
        <property type="entry name" value="CYC2-LIKE CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="658" mass="68868" checksum="EA2DB15D7D219635" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGB3</accession>
    <name>A0A3Q8IGB3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320031000</name>
        <name evidence="3" type="ORF">LDHU3_32.3170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGB3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320031000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3170"/>
    <dbReference type="OrthoDB" id="271578at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14937" checksum="05232428FF8DD0F0" modified="2019-04-10" version="1">MRLSPSTRTGYVKSALRDLTKGRNAGHDMGKEAPSVPADTREVRGKHTVRPLRWQMIRPPVALRSRHGHHLVSCRERLYVISGCYWAHGNALASTDMMYDVCTGASQQISFPFPQRFCAALAKSDAVPATPWTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGU5</accession>
    <accession>E9BPN3</accession>
    <name>A0A3Q8IGU5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription elongation factor-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Transcription factor S-II (TFIIS) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_37185</name>
        <name evidence="12" type="ORF">LDBPK_332950</name>
        <name evidence="11" type="ORF">LdCL_330036600</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864119.1">
        <property type="nucleotide sequence ID" value="XM_003864071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGU5"/>
    <dbReference type="GeneID" id="13392515"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4100"/>
    <dbReference type="OMA" id="ICFFETS"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000052">
        <property type="entry name" value="Transcription elongation factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="9">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="323"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="431"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP53586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="473" mass="50764" checksum="6D6D91310629EA94" modified="2019-04-10" version="1">MATYVPGDRVWVYIEGDGWWPARVLSDEEMGTRTPGFDLAVQFYAGVEQPATLYELNSHADAANICFFETSSEKAVTGNPELEASIRCACADAEANPLKSASAIVGGARVAAGGSGAAGSAGAAAVNRAAVKRVRDMGDDDTGTYGGGAAASRSASGYHHLRSDELHELSSKISSAVAAADLTAVRAALCQLDGVDVYLTELEDTKIGVAVGSVLSQPALKPLWPLARAMISFWARHLPAETLAAIRSVQQRQLPVPAISAAAAAEPSSPHNKRQQPLPAVPSRSPFASSVSPSAATAAGGAVGGAAAGACSGDVAPTQRKTFYDNVYQLLDSPLSTTRYDDTVIDEVARKLATEITDRDERQMLLLRLREEELSFIRDHLLSGEWTPKKYLDQPNEVFTTKSEKARQEQRIQEKMKAIEAADNAMLNITSLFKCGRCSKRHCTFYEQQTRSADEPTTKYITCLDCKNTWTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHJ0</accession>
    <name>A0A3Q8IHJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Actin-like protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Actin-like_protein_putative/GeneDB:LmjF.34.3760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_27085</name>
        <name evidence="2" type="ORF">LdCL_340045000</name>
        <name evidence="3" type="ORF">LDHU3_34.5810</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHJ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340045000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5810"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="422" mass="45340" checksum="839734F53BDFF39B" modified="2019-04-10" version="1">MSVVEVGTFNVRAGYIGDATCTRCVPALRAAAAPEEVDLISLLYAAGKSLDAVPLPSSSDFANEEAGGPADPLLSQGSGAHSNALLPLWSLRQVESYPKAHIDSLRRLKRDVLENAEQDPLCLVLPEVWHERIDVLEALFQLILEAPGLTTALYCMRPSVGWTFASGAASSIVLDVGHSRTTVTAVLDGYALRHSVDTIPVGGDAVTAQYSELLSKHRPVVEAAAPALSHSTVREIYWRDWVADVKHCLARVLPYQGDTGGVASAAGKGSASTAVKEATVRAVTDLQAPDGTRVHLDERTAALPFEVFFSATGDEKRNVATLMAMCKRRMDPEWQLHTVPHLLAGAGSLVPGFRDRVVGELKAQDSSYFRYERDGVLNVAQTADGAWVGASMAASSSSFEPLWVTRGEWAEEGASVLYRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJB4</accession>
    <accession>E9BS49</accession>
    <name>A0A3Q8IJB4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein-associated roadblock protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Roadblock/LC7 domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_0175</name>
        <name evidence="5" type="ORF">CGC21_6375</name>
        <name evidence="4" type="ORF">LDBPK_351740</name>
        <name evidence="3" type="ORF">LdCL_350022300</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864758.1">
        <property type="nucleotide sequence ID" value="XM_003864710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJB4"/>
    <dbReference type="SMR" id="A0A3Q8IJB4"/>
    <dbReference type="GeneID" id="13387638"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2280"/>
    <dbReference type="OMA" id="HDYFMIV"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000011">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="119" mass="13523" checksum="358C8D4D6F169063" modified="2019-04-10" version="1">MNLFSNCRVTAHRSSLHSTRKAMSEIAEMFQRISQRPNVTGIIVVDNEGTPIRSTIEDTTVQNQYAHLITSLAAKARHCVRDLDPTNDLCFLRIRSKKNEIMVAPDKDFILIVIQNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJN1</accession>
    <name>A0A3Q8IJN1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein family UPF0564, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_320042200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJN1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320042200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4580"/>
    <dbReference type="OrthoDB" id="2150121at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF1">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="805" mass="85718" checksum="91FF51F786971D60" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJV5</accession>
    <name>A0A3Q8IJV5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360013400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJV5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1110"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7694" checksum="948A7BBD8B9BB7E9" modified="2019-04-10" version="1">MMGLGCFGFVMNVLVNSMRYCSSEHAQSPGGLFEGHDDDQGRSHEDGGHHHYENGHEDDHGSVHARLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK74</accession>
    <accession>E9BTU7</accession>
    <name>A0A3Q8IK74_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmentally regulated GTP-binding protein 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Developmentally_regulated_GTP-binding_protein_1_p utative/GeneDB:LmjF.36.2250</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Small GTP-binding protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_28780</name>
        <name evidence="9" type="ORF">CGC21_13480</name>
        <name evidence="7" type="ORF">LDBPK_362380</name>
        <name evidence="5" type="ORF">LdCL_360029500</name>
        <name evidence="6" type="ORF">LDHU3_36.3170</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865353.1">
        <property type="nucleotide sequence ID" value="XM_003865305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK74"/>
    <dbReference type="SMR" id="A0A3Q8IK74"/>
    <dbReference type="GeneID" id="13388239"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3170"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="368" mass="40998" checksum="27310C69E1B7C0C8" modified="2019-04-10" version="1">MSSLQKISDIEAELARTQKNKATMAHICALKARLAQLKRELIASESKKGGGKGEGFDVQKTGDARIGFIGFPSVGKSTLLSKMTSTHSEVAAYEFTTLTCVPGVVNYRGAKLQMLDLPGIIEGAKDGKGRGRQVIAVARTCSLILIVLDIAKPLQHKLIIERELDGFGIRLNKSPPDIVIRKKDRGGISISSTCPLTHIDQETIKIILGEYRMANADVTFRGDYTADEFIDAIEGNRAYIPAIYVLNKIDQISIEELDIVARIPHNCPISAHHEWNLDGLLECIWDHLNFIRVYTKPKGQVPDYDAPVILKKSPQPSVESFCNRIHRQLIRNYKYAWVWGSSVKHQPQRVGKDHPLDDEDVVQVVKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKS5</accession>
    <name>A0A3Q8IKS5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_200021700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKS5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2060"/>
    <dbReference type="OrthoDB" id="271393at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26301" checksum="3423C2524E82AEEB" modified="2019-04-10" version="1">MSFASGLLRDISPSTRSASTNAAIDSTVGDVLWDLCERMDYYVQYNIPSSWQVTELLRDNSIAIQCSPPPPTEAAEGSGAAVHGISLNCFAYKQRVKQADSVRLLHVFLKRFNASVNNSLELLSEGHPPPPLAEVRIPANGSSGGAVDARTVTSAHSRDTGDDEGTCQTLAKQLNSAVAEVTFTPSPGQPLAHGLCRAFYNSNGRFHYVIVVAVPEEEYANSLDLMIHALASVVESRVEAAAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IRQ2</accession>
    <accession>E9BLC8</accession>
    <name>A0A3Q8IRQ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">KU80 protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Ku70/Ku80 beta-barrel domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC21_34980</name>
        <name evidence="17" type="ORF">CGC21_34985</name>
        <name evidence="15" type="ORF">LDBPK_300340</name>
        <name evidence="14" type="ORF">LdCL_300008500</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862748.1">
        <property type="nucleotide sequence ID" value="XM_003862700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IRQ2"/>
    <dbReference type="GeneID" id="13385455"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0480"/>
    <dbReference type="OMA" id="WAMQYVW"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000146">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000004">
        <property type="entry name" value="KU80 protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000018">
        <property type="entry name" value="Putative KU80 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599620" evidence="12">
        <location>
            <begin position="20"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Ku" evidence="13">
        <location>
            <begin position="300"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP45605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP45606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="798" mass="85783" checksum="08247F2CC8A5C13F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITY0</accession>
    <name>A0A3Q8ITY0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_330017600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITY0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1760"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF17">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22998" checksum="8CE1F3D9F1F78182" modified="2019-04-10" version="1">MSKPLNALVVCGPSGVGKGTLLGRLLREYPNRFAYSVSHTTRQPRQGEVNGREYHFTDRESILKMRDNNEFLELCDVHGNFYGTSVAAVHAVQKEGKVCVIEIDVKGAQKLFNRTDNALNAVYFFITAPREELRKRIMKRGADDETMLQRRLETAELEYKFVDENPDFFSVLLVNDELEAAYAALLAAIDDQLVKHNMEKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IWI0</accession>
    <name>A0A3Q8IWI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A distinct subfamily of CDD/CDA-like deaminases, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360069400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IWI0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360069400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8210"/>
    <dbReference type="OrthoDB" id="270344at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000102">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032723">
        <property type="entry name" value="Deaminase_LmjF365940"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14421">
        <property type="entry name" value="LmjF365940-deam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="624" mass="68870" checksum="ED3E00B52E22542B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H508</accession>
    <name>A0A3S5H508_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_020011100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0720"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1641"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2117"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2598"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3013"/>
            <end position="3061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3186"/>
            <end position="3206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3361"/>
            <end position="3380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3428"/>
            <end position="3459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3502"/>
            <end position="3566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3583"/>
            <end position="3605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3618"/>
            <end position="3641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="923"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1814"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2129"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3044"/>
            <end position="3061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3188"/>
            <end position="3206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="3442"/>
            <end position="3459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3502"/>
            <end position="3512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3534"/>
            <end position="3543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3545"/>
            <end position="3565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3788" mass="400898" checksum="B35786370B9B139D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H598</accession>
    <accession>E9B7Z9</accession>
    <name>A0A3S5H598_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_2605</name>
        <name evidence="7" type="ORF">LDBPK_040330</name>
        <name evidence="6" type="ORF">LdCL_040008800</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858096.1">
        <property type="nucleotide sequence ID" value="XM_003858048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H598"/>
    <dbReference type="GeneID" id="13390707"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0400"/>
    <dbReference type="OMA" id="FTCWDLG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU75812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="184" mass="20516" checksum="ECB9693DA2C18380" modified="2019-04-10" version="1">MGQLFTSLWSMFKGNKSYKLLILGLNNAGKTSILYYLQLGHSIATQPTLGGNTETLTITHPQTNNTITFTCWDLGGQEQLRESWKLYYDHTDAVLFVVDAADAVKFPKAKEVLHQLLHGEPSLQHATLLVLANKQDMESAAAPAELIEYLELGKLRDRTWTLMGCSTSTGESLREAMNWIAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5E7</accession>
    <accession>E9B877</accession>
    <name>A0A3S5H5E7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HAD ATPase, P-type, IC family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Proton motive ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_2975</name>
        <name evidence="10" type="ORF">LDBPK_041120</name>
        <name evidence="9" type="ORF">LdCL_040016800</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858174.1">
        <property type="nucleotide sequence ID" value="XM_003858126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5E7"/>
    <dbReference type="GeneID" id="13391022"/>
    <dbReference type="KEGG" id="ldo:LDBPK_041120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1370"/>
    <dbReference type="OMA" id="CDEYTQL"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="8">
        <location>
            <begin position="124"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="900"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU75892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP51527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="957" mass="101842" checksum="A170C8E944430B78" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F2</accession>
    <name>A0A3S5H5F2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040017600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1450"/>
    <dbReference type="OrthoDB" id="273460at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF18">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1910"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2272"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1910"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1929"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2276"/>
            <end position="2293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2395" mass="253901" checksum="DF222F93BF5C6AC7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5H7</accession>
    <name>A0A3S5H5H7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050009300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5H7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0500"/>
    <dbReference type="OrthoDB" id="426586at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42254:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42254">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="72867" checksum="50B60A76EC5E5278" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5R6</accession>
    <accession>E9B8S7</accession>
    <name>A0A3S5H5R6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lanosterol synthase, putative</fullName>
            <ecNumber evidence="11">5.4.99.8</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Squalene/oxidosqualene cyclases family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_24255</name>
        <name evidence="12" type="ORF">LDBPK_060670</name>
        <name evidence="11" type="ORF">LdCL_060011800</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.8" evidence="11"/>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858373.1">
        <property type="nucleotide sequence ID" value="XM_003858325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5R6"/>
    <dbReference type="SMR" id="A0A3S5H5R6"/>
    <dbReference type="GeneID" id="13391743"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0780"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016871">
        <property type="term" value="F:cycloartenol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="392"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="654"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP54844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113655" checksum="31B3C6ADD9B82596" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H663</accession>
    <name>A0A3S5H663_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_080011900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H663"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0990"/>
    <dbReference type="OrthoDB" id="244479at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22662" checksum="2F57761F4D004932" modified="2019-04-10" version="1">MACKLGVIIYVVLQFIAFFSVLIGTGVDMFYIKPEHSFGIRVCITLWGGKTDCRKANVTISSDTRWKFCPIRRNNFRIGQAFAVISIFVYGAAFLFGFLLLYCCAGFRWLCLALNIVGAVTACVVWAVMVVTYRLPEPKCLELSDGYDFGTGFGLFVLAWILDIIDVIFLMLPWQIGEFGEGDEPNVQEEEEEVGSKKATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H691</accession>
    <accession>E9B9K8</accession>
    <name>A0A3S5H691_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guide RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Guide_RNA_binding_protein_putative/GeneDB:LmjF.08.1170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_081080</name>
        <name evidence="2" type="ORF">LdCL_080016400</name>
        <name evidence="3" type="ORF">LDHU3_08.1530</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858667.1">
        <property type="nucleotide sequence ID" value="XM_003858619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H691"/>
    <dbReference type="SMR" id="A0A3S5H691"/>
    <dbReference type="GeneID" id="13391944"/>
    <dbReference type="KEGG" id="ldo:LDBPK_081080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1530"/>
    <dbReference type="OMA" id="QFDAMGL"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF71">
        <property type="entry name" value="MITOCHONDRIAL RNA BINDING COMPLEX 1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="442" mass="49761" checksum="6BA4C62447DFF230" modified="2019-04-10" version="1">MKKLHQERGGNPMLAQQARRVLFATSITGQNIDARSVALLLNTAVYFGMESDARVVRECIDFCLKNDKFISLDIMPIVVTACATLKSRDAREVIELQAIKATKNARFLDAKGVTNIISAFSKTGINHEKLFGLLSMRVQTLARVGEFEAAHLVILANAFARLRFREQHVFGAIARRAMSLRERVTVNELVPLINAFSKAGLKDPKLSKRFAGKAMEYVDQMNAEQVAMMFQAFAYFGIRYDQLFGVLTNRAVELIDEFNAQYISTTLASFQRIGINNPELFDNLAERALAVVQDHDAKDIALTVTALAHFGLKDEELFKRLASHAASIADQFDPVGLVNTIHAFARTFFLQEDMVVALSERCVYVCRHLDANQVRRLLWSLAKFQVKDPRILTPVFNRCLTLHQDFFSDPMGGEEIEEIFDVFGPSFCPPLYQLYMSRGNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6A2</accession>
    <name>A0A3S5H6A2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080017800</name>
        <name evidence="3" type="ORF">LdCL_080018500</name>
        <name evidence="4" type="ORF">LDHU3_08.1700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6A2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1700"/>
    <dbReference type="OrthoDB" id="273553at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="509" mass="53827" checksum="D860BEE671C460FF" modified="2019-04-10" version="1">MWRAEENIFARARPARLDTQYSSTGACTTAPPARTLMPPRWFHVPGSGARDAQGPPEGLVTSTHLSSSLLLQRSSLLDHGGTADASAHALGCGGRDADGSCWGIAGPSPAMQPQQPFAPHGGAGTRDTRSLGSLLCHPDLRPTRDTSADNTSPTEVSRLLRQYRDENARLREQLKAKELHEAHIMARLEETSHRCAHLQLAWQRASGDTPSSLLQSAGDKADAAQSVGSHGGEAEETVQSRLAQKEAEVRELQGRVEAYREALQRSRAHAALSEEERRAAAAPATCAAGSVSPTSLHVLLLQSLNAADYLVKVFNALQHCHCTRHGDAHGSASDCCRRSLHDCKVRCLQAAVKGAPISSELLELEDGPENDTAAANMETAVAVREELLYCEAVAVRLAASLLSRERTTDEDAAPPATTTAAAAPPEKAASPPPLSALGPLTALGVAEPVALAKAAAAETHDDGDDEGAGEGEKSTEENGQATVSYVAAAREPRRRPSRCRPDVGDCEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6B8</accession>
    <accession>E9B9S7</accession>
    <name>A0A3S5H6B8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent protease ATPase subunit HslU2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ATP-dependent_protease_ATPase_subunit_HslU2/GeneD B:LmjF.09.0230</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Heat shock protein HslVU, ATPase subunit HslU, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_090380</name>
        <name evidence="8" type="ORF">LdCL_090007600</name>
        <name evidence="9" type="ORF">LDHU3_09.0330</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858720.1">
        <property type="nucleotide sequence ID" value="XM_003858672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6B8"/>
    <dbReference type="SMR" id="A0A3S5H6B8"/>
    <dbReference type="GeneID" id="13392040"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0330"/>
    <dbReference type="OMA" id="EYTEAGY"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003544">
        <property type="entry name" value="PRK05201.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF2">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE ATPASE SUBUNIT HSLU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600564" evidence="5">
        <location>
            <begin position="18"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="83"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="7">
        <location>
            <begin position="395"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="503" mass="55674" checksum="9521C3F2A326C67C" modified="2019-04-10" version="1">MLRFPTRLLFCVATAASTPSPDVLQVTKEKASKLDDLSPRAITKILDAYIVGQDAGKRAVAIALRNRWRRRQLSDADLRKEVVPKNMLLIGPTGVGKTEISRRMARITDAPFIKVEATKYTEVGFKGKDVESIIEDLYTNAKLKARRALEAERHAEALNMALDTVYSAWSVSQRMRAMDRSLLSTGKAEEVTAAAADDSAAEAEESQPQQQQHNFEYFREHYLDEPITNDMVTIDINAPQAPTKPPKEGGIDLQSVGMLLGLGGEPKRLKVSVTKRVADAVPLATQEALDKLIDEASVNTLARALAEEEGVVFVDEIDKVVAEPSSANADVSSTGVQQDLLPLIEGSNVTMKDGSVIATDNILFICSGAFHVVKTSDMIAELQGRLPVRVELQALTEEDFRRILTEPKFNLLRQQEEMLKTEKIDVVFTEDGVNELAKVTCAVNSQGQNIGARRLNTILERVMDPYSFNCEEYEGKRVEINAKMVREATEKLQKNVNLAKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6H5</accession>
    <accession>E9BAI3</accession>
    <name>A0A3S5H6H5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_23220</name>
        <name evidence="2" type="ORF">LDBPK_101410</name>
        <name evidence="1" type="ORF">LdCL_100021300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858973.1">
        <property type="nucleotide sequence ID" value="XM_003858925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6H5"/>
    <dbReference type="GeneID" id="13389485"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1800"/>
    <dbReference type="OMA" id="CCITSFV"/>
    <dbReference type="OrthoDB" id="255875at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015045">
        <property type="entry name" value="MPT-1-like_LmxM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036:SF2">
        <property type="entry name" value="DUF1861 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP46537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="313" mass="34860" checksum="92E02902E14B9730" modified="2019-04-10" version="1">MSFKEMRLAFEVSKNIYESSLLTFKGVDGYDVYNCSLLFQYKGKHHLFGRFERREKSSDSRVRLFVETGKDEYTVVPDQLTYQLEDPFVSKVQGSLFFGGTQVIKSGGNVTGYFCDFYHGMPQLLTYYTTGPDLMRSIRIVQLADGTIGIFSHHKTESSCLIGFTTVNSLNEVTREVIAEAKPINNAPFLDAWGGVNQAYLLSSGNIGCICHHSYLDKDANGEQRNVCCITSFVYDPKTNDTHGFQLIGTRGCFPDCPSKSPSVADRAFASGIVMRNDGKCDLYSGLGDTCEGRITIDYPFEGYGTVVNDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPS7</accession>
    <name>A0A3S7WPS7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_070008100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPS7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0380"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="848" mass="90812" checksum="13CA67C1BF3BA91F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ05</accession>
    <name>A0A3S7WQ05_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_070014500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1140"/>
    <dbReference type="OrthoDB" id="266420at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40738">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40738:SF1">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019277323" evidence="2">
        <location>
            <begin position="33"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1798"/>
            <end position="1819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1977" mass="201874" checksum="3741DAECD7ABDC97" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQJ2</accession>
    <accession>E9B9P0</accession>
    <name>A0A3S7WQJ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_18505</name>
        <name evidence="2" type="ORF">LDBPK_090040</name>
        <name evidence="1" type="ORF">LdCL_090005300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000045">
        <property type="protein sequence ID" value="TPP41934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858683.1">
        <property type="nucleotide sequence ID" value="XM_003858635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQJ2"/>
    <dbReference type="GeneID" id="13392064"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0060"/>
    <dbReference type="OMA" id="GMICCSH"/>
    <dbReference type="OrthoDB" id="276665at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="619" mass="69256" checksum="0E34E2F78F8338A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR17</accession>
    <name>A0A3S7WR17_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_100008600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR17"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0470"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1670:FF:000019">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000043">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="99"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="254"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="10">
        <location>
            <begin position="415"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="7">
        <location>
            <begin position="660"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="803" mass="88499" checksum="AA409EFCFF39EBE2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR18</accession>
    <name>A0A3S7WR18_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanosine diphosphatase, putative</fullName>
            <ecNumber evidence="7">3.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_100006700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="7"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR18"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0260"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019424337" evidence="6">
        <location>
            <begin position="29"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="361"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="677" mass="73487" checksum="E724D1801F246458" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR99</accession>
    <name>A0A3S7WR99_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_100015400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1220"/>
    <dbReference type="OrthoDB" id="273113at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1755"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1798"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1820"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1830" mass="193849" checksum="DFE3E45F2D9ADB59" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSZ6</accession>
    <name>A0A3S7WSZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ion transport protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_140010900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSZ6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0750"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="3">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="499" mass="55975" checksum="9E2721059F7D9B37" modified="2019-05-08" version="1">MKRSITKGPRLLGRRIKHFLKDDLYIDVSYQEAPPKMVARELAALEVLSVYHRWLRGVQALLSIAVFMLSLLSIGSSAFLVNCTIFIVSQAAALVICKTYQVKAQFSGVTNLLFEGRNIFTSPYFLHMVAEIVLWNIQTPPFVFVGKQFFELLNYFIFLRLYSVIVYLNNAMYVHRTFCRAMSAISDLPLSTSFLIRTGLLHHKTRVVVTVVICAWLTVGCLFARTQNLSLGDALWFSFQSLSTLGYGDITPSTLSGRVVAFIAWILSYVIMAFLIITMYSLLQASDRSHNMQTLMECHDLAHSLRGRSARVIQLAWRLRKARKVGPHAPSLKQKVYTLALSWLLTDMISAVRRTRQQLNGAVRSLSETNIHPLTGLSAYQYNAYLQLTEKAARQLQRAKDVDRVHLALRDRDVLASSLSRRDIETIIVLPGDSLEPIGTALPVALTSSSGTAASVAEMAEWRDRVTQLEQKCARLTEVLEAISAVAETHPPSMAVSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUD2</accession>
    <name>A0A3S7WUD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170011200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUD2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0880"/>
    <dbReference type="OrthoDB" id="264689at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="846" mass="86368" checksum="DF18ED23C647F945" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW64</accession>
    <name>A0A3S7WW64_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pumilio protein 9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200018900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW64"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1790"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000665">
        <property type="entry name" value="Pumilio protein 9, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF50">
        <property type="entry name" value="RNA BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="89"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="546" mass="58387" checksum="50582588A34C78B7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWH1</accession>
    <name>A0A3S7WWH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Temperature dependent protein affecting M2 dsRNA replication, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_210014000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1020"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF28">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="879"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1372" mass="149694" checksum="1B0C9F66CC1E84A4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWI4</accession>
    <name>A0A3S7WWI4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_210010900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWI4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0640"/>
    <dbReference type="OrthoDB" id="10262375at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052628">
        <property type="entry name" value="CFAP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1154" mass="121788" checksum="D2CB4B949EDE275E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWT1</accession>
    <name>A0A3S7WWT1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine Rich repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210020500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWT1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1780"/>
    <dbReference type="OrthoDB" id="265672at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="52570" checksum="917068D1516DCFF4" modified="2019-05-08" version="1">MSSTLVAVYEQACSDAAVLPNSALARCFAAAEQAMPLRVLSLSTNLIGPRGLVALLPVLRECRHTLHTLDLSHNSLGNATIRQLVLCFSNGGFSALRRLELRGNLLTYQGGKCLVHWCEGLRTVRQTHGTRLPGVGEVEGRSADSLASAAPSGAPASPLRCPEYWCDAADVHIDYIGIEDTAMPEMLQRALLQRITDAMARREARRLGHSSQRRSLSCVVTRESGPVADTSGAADSPRQFSADAESVKVPVLDGPPITGTAHPFARSPADFFMDDNGEPQHSDGMKVDAAVGFEAVAVTEARETDVPCFLQDDIGVDVLQKPAHDYASADDSVSGGAEELKDVRDGNGYHSDNSPAAGVAGTLLSVNACTDQRSLGMHWRSGSVAETLPFPDHPMKEGSGADARCAVSCLRSTASPPMSPTSADGFALYAAEPSEAAAAQQQQQQEEVERYPPPPLKTASNILDELGLEAVAETAGGGGGGGGMEEDVDAVPMWLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXN1</accession>
    <name>A0A3S7WXN1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAP2 superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230013600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXN1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0990"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="236" mass="24827" checksum="2A28B817D2BCEED7" modified="2019-05-08" version="1">MFLSCINYYVDKNCNFGVVSAVLLVNVYVLQYLPGTVVVPFLTLCACITAGVSKGLKRIIKQPRPPGAPKASPGMPSNHATSLSFLSVVTVYVLQRYASSTAVVGGANQTLFHTPPLPSLPLPCVRPLQVLIAVYSVYATGLRVAQGHHTVAQVTAGYLLGSTLAILSLAANHSGYTGTRFGGRVDELPLPEKVIMLFASVAISAMAMRSIVRGSHVSSVARTSAPVMKGVEEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXT5</accession>
    <name>A0A3S7WXT5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_230017100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXT5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017100"/>
    <dbReference type="OrthoDB" id="268003at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18906" checksum="81E4018B436D23FE" modified="2019-05-08" version="1">MHTTARLRVRASRPSELYDPISGLPRKPNEVPAVYLQSMAAEAAARVVSYRHGDGGPHASMDARANSSSVATKRQIRSGAFAWADKLSGLAQQRRARATARSAQLHSTRRVTGLPLRPDERRLYWAEHAPLHKTSVRGLNAVLQGVGEAEEGLLVEGLGPRGAWAKRESAGRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYJ0</accession>
    <accession>E9BH36</accession>
    <name>A0A3S7WYJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16470</name>
        <name evidence="4" type="ORF">LDBPK_241740</name>
        <name evidence="2" type="ORF">LdCL_240023000</name>
        <name evidence="3" type="ORF">LDHU3_24.2150</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861264.1">
        <property type="nucleotide sequence ID" value="XM_003861216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYJ0"/>
    <dbReference type="GeneID" id="13391186"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2150"/>
    <dbReference type="OMA" id="PRLEWFY"/>
    <dbReference type="OrthoDB" id="275152at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="274" mass="32296" checksum="AF68DD48F9A353F3" modified="2019-05-08" version="1">MLRSTHVSRLVTSGSVALTPSCWTTKPAGWYLVPSSTLPETEELRVSKRFDFLNHSAQYLFLGQVMALAEEVKCIPSLEWFYTELSFSLPPTKEAEVLANYMNDQERLRCGLRNHSEGGTSSSDIAWSRELKERVQRRAEEDFCWLLTHDQRKTEKFLQETFIQWHHRADYLVTRKSREKREFREDLTLQKVIQQGQERKRRMQRRRNRDEARQEAIKSGKESEWDNFTHDVLPRELREALDRESDGMEDVRLSRAGTATGGWSRSMRSHPNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0B8</accession>
    <accession>E9BIU2</accession>
    <name>A0A3S7X0B8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_31400</name>
        <name evidence="5" type="ORF">LDBPK_270070</name>
        <name evidence="4" type="ORF">LdCL_270005600</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861865.1">
        <property type="nucleotide sequence ID" value="XM_003861817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0B8"/>
    <dbReference type="GeneID" id="13389126"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0090"/>
    <dbReference type="OMA" id="EWSVEVV"/>
    <dbReference type="OrthoDB" id="272466at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600668" evidence="3">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="313" mass="33647" checksum="BBF4C8018625DBC1" modified="2019-05-08" version="1">MARTLLFLLSILVIAAAATAHELHLPADIYDHAAGEWSVELVSSCRLPLLGSVTFHNNTAVVEWKEVGAPEMKISGRSATSSLSVAALSDFLTKDSHELSYVMCERQENYLATPQRPVQVAGMTTTYIKAYSGVLSSSSDGSTCDGSSERTIAIQALGAPFTPSKGKAWQMKEALYAIDIVLDTRNVEGTCASKRGAGVSDAALGNDKRSRKRRAHRTLSSGMAVSTADAMTAENGIVTLRFIRRSAAHQPWFIRYYTPIVFATIFIMYRMAHSFSYTRAAKSSPRSESSGGETAGDAGRIALSGCNSNSIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0D1</accession>
    <name>A0A3S7X0D1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_270007100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0D1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0280"/>
    <dbReference type="OrthoDB" id="275765at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000042">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="314" mass="34522" checksum="284F5625FD04D64F" modified="2019-05-08" version="1">MHDSVDGFWAACSGCGATSKRLLIHKTGVAASPIGLVTGEAVKHGSPLINVPYNSVFNGQTLRGDVLPRALPSLRKMLLFLTRRGRMGVVTAHSLWLACFVACYRQQCAVTNKAGRWLLQPLLSSTVYPPLPNLFSERNKFACPSLRASSAAELEVMERRVQDELDLTYSMLRHYMKRRGVSSKLRPSRDMLVQAHRTVMQRALLLPRNGEPSAPAELSELIETSPDLPLFPSLVPAIDLIRAAPLHSRAEAEEDAEPPSSGNCSIFTCVQSDFLSSSSRRRVIVETAPLAARRVVVCATKPLTEGTELLMEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0U0</accession>
    <name>A0A3S7X0U0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytoplasmic dynein 2 heavy chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">LdCL_270023500</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2520"/>
    <dbReference type="OrthoDB" id="10252139at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000706">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000598">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001685">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="13 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0243">Dynein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="23">
        <location>
            <begin position="1234"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="24">
        <location>
            <begin position="1795"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="30">
        <location>
            <begin position="2609"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="26">
        <location>
            <begin position="2792"/>
            <end position="2999"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="25">
        <location>
            <begin position="3046"/>
            <end position="3379"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="27">
        <location>
            <begin position="3404"/>
            <end position="3625"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="22">
        <location>
            <begin position="3875"/>
            <end position="3985"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="28">
        <location>
            <begin position="4017"/>
            <end position="4152"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="29">
        <location>
            <begin position="4185"/>
            <end position="4451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1294"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2729"/>
            <end position="2748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="3045"/>
            <end position="3117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="3264"/>
            <end position="3333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="AYU80063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4455" mass="498553" checksum="78629059509A7389" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X120</accession>
    <name>A0A3S7X120_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_18540</name>
        <name evidence="3" type="ORF">LdCL_270033200</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000015">
        <property type="protein sequence ID" value="TPP53940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0830"/>
    <dbReference type="OrthoDB" id="273844at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="454" mass="49868" checksum="58FCD18439D8073C" modified="2019-05-08" version="1">MHRSTRQRHAPPAAARRAEDATVPSSLKKDPLPVCKRREAATRSAQLTDLFDSLSAADAKALQSTQLGEDFADDFTNEGAEGLLSATLFSRRPPLSTSAPPDHAANGVSSSSTGELVLRSGRAAAPSTNSHDLPRPFHEQALAVRSVEVAATEMQSTLQQLQHDLAFHVKRRIEAEREAGGHLASAPRPRPSSDSESVTPLRAETTAAQQRRMADPDVLSEAARIQRARAAAADEGLSDNQSVEDYGVDCEVPPLTSDSRLVDEVAAIAVCMAKMKESAKVMYDTEATAPSTSTAPWWSSALHMRDMKASAARLDYHAHTALNWSHRSMEQLLLQAVMLNNVSVSTRTQLLEQQQHWQEFQTRLRDGQQTVTQLQADIARYQARVQAEMARRAALQEELRLCAQERGLVDPGERNPLKAELALLLEEREWPSPTLKKDASVVLDWLRSVSTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X154</accession>
    <accession>E9BK79</accession>
    <name>A0A3S7X154_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LDBPK_280410</name>
        <name evidence="14" type="ORF">LdCL_280007600</name>
        <name evidence="15" type="ORF">LDHU3_28.0360</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862140.1">
        <property type="nucleotide sequence ID" value="XM_003862092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X154"/>
    <dbReference type="SMR" id="A0A3S7X154"/>
    <dbReference type="GeneID" id="13386876"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0360"/>
    <dbReference type="OMA" id="LPYCCLY"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000348">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5431409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="215" mass="24787" checksum="E64243348C605CD8" modified="2019-05-08" version="1">MSPQLMDRVNASEYLIRDIFKRYAPSEIGVAFNGGKDSVVMFELLRSAVTAPVLAQCCIFVVEHNDEFDELRKFRAWYMQEVARGLPLVHQGASQDMRLSLWTLTEKHPLKVVFMGTRKTDPHGRYQKEAVEKTTPGWPDFLRACPLFHWSVNDVWAYTRLMCIPQCSLYESGYSSVGRSADTNRNPLLRRDDGSYRPAWELTCDNAEREGRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X391</accession>
    <name>A0A3S7X391_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette protein subfamily H, member 3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_300019100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X391"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1770"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002144">
        <property type="entry name" value="CCR4-associated factor 16, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="208"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="441" mass="49006" checksum="3B2428001A9CF5E1" modified="2019-05-08" version="1">MIGAPWPPEAVFGNTVDRVASPAPVPERKASIADALHLRLSRFLEKMSWGERRRVQILYGMLYPATLYLLDECSTDIDVAERRTVLELVRQECEAKDGCCVYATHILDGIEGWATHLLLMEGGRVVDFKALEKLTMPLEDYALQFMSKRAHAARGFDAVAAPSLSQGSSAAISTTLSACPTTSSAAYPTPSTADAPVTYWPRGHADEKRSEIVINCAQLNYKDVFKNLSFQVFRGERVLLCGGNGTGKSTLLNMLGGKQFFDNRHGSLSVLGKRCYDDMLLNALVSYGGDWWTAVPGGEVHVREMLQLRTSRAERLREMLAVDIDWDVRHISAGEQKRVQLLLHLLDDKPVVLLDEATTDLDVYQRHSLLQFLYEESVQRGVTVVYSTHIFGGLEGWANAVVLLDRTMRGVHAVWRASEGQPISLQRVVDAIVALKAREAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3S9</accession>
    <accession>E9BM62</accession>
    <name>A0A3S7X3S9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translocon-associated protein beta (TRAPB) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_6265</name>
        <name evidence="6" type="ORF">CGC21_36285</name>
        <name evidence="4" type="ORF">LDBPK_303190</name>
        <name evidence="2" type="ORF">LdCL_300037500</name>
        <name evidence="3" type="ORF">LDHU3_30.4260</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863030.1">
        <property type="nucleotide sequence ID" value="XM_003862982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3S9"/>
    <dbReference type="GeneID" id="13385739"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300037500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4260"/>
    <dbReference type="OMA" id="EMNPHPL"/>
    <dbReference type="OrthoDB" id="5860827at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002489">
        <property type="entry name" value="Conserved repeat domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600681" evidence="1">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="212" mass="23265" checksum="83FA795149B5AABD" modified="2019-05-08" version="1">MATLKVLLLLCLATLVATTCFAQVAQEAEINPHPLLFVSKTTSSDDIVLGSSVEVVVTVTNYGQSPAFDVQISDLLEDGSLQSKSIAYLPYGASETLRYTVTPTALGNYAVSVAEVTYNVEQGNTATARKALSNLIREGEAYYYGEGVDDESFRGVISVLTRDRYDRLHARYIKESTAYIFLGAIPALFPYVLYRVKQSEVDALLRQRKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3V5</accession>
    <accession>E9BM89</accession>
    <name>A0A3S7X3V5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_36420</name>
        <name evidence="10" type="ORF">LDBPK_303460</name>
        <name evidence="9" type="ORF">LdCL_300040200</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863057.1">
        <property type="nucleotide sequence ID" value="XM_003863009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3V5"/>
    <dbReference type="SMR" id="A0A3S7X3V5"/>
    <dbReference type="GeneID" id="13385766"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300040200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4610"/>
    <dbReference type="OMA" id="MYINAVA"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002656">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="8">
        <location>
            <begin position="130"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="617" mass="66661" checksum="C18D1B0FD6E94A24" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X483</accession>
    <name>A0A3S7X483_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310014100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X483"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1240"/>
    <dbReference type="OrthoDB" id="265961at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="649" mass="71091" checksum="614F74C2C41D0806" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5B1</accession>
    <name>A0A3S7X5B1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_320012700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5B1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0890"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="226" mass="26546" checksum="38A940F53B9B1EE3" modified="2019-05-08" version="1">MARDTAEKKGFKAAMGMEAMKGKMESVKHSKRSKYTPASQHSHGNPIHRPLKFHERKLLKKHDFMQYPQDNWHEPFCITKYHLEDREDYRRYMRLVGLIRQLQTQLRYLPADSKIRIQITQQLMEKLYNMGLIHEKLGLAEVDKVGVEAFCKRRLPTILRDLKMAGNCKLGAEIVHHGHVRVGTTQIRDPAFLVPRGLDDYVTWMPGSKIRQHVDTFNAMRDDYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5I4</accession>
    <accession>E9BNS2</accession>
    <name>A0A3S7X5I4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_20395</name>
        <name evidence="2" type="ORF">LDBPK_321690</name>
        <name evidence="1" type="ORF">LdCL_320022400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863585.1">
        <property type="nucleotide sequence ID" value="XM_003863537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5I4"/>
    <dbReference type="GeneID" id="13390635"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2150"/>
    <dbReference type="OMA" id="FFGSCFT"/>
    <dbReference type="OrthoDB" id="270946at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="291" mass="32780" checksum="3A9927F39EAD1160" modified="2019-05-08" version="1">MFEEISFDDVDVSCASHEDDRLVAENVADAVEGGKAFVRFHRPGEEGFSIVAGACDDKDARHDAHFMSGDAWMSKDCHCIQCETLRVLSRYSEMRAQPNISPVIVLVDLDNFGFNQFKSIPPYPDVELLDHVLVWSFFGSCFTRHHRAWPSEQTVCEPLPNRAVSVNAAGTTKRSIWEILVSKQQVFFTPCGGQTQAADNVMHRVLQALQGMETVLLTGDVKLINEIYRSRRLLGMKSRRHNEDEMSDKLTVINVDDMDKRFVPVWRSLCNRLRGTLHDVGATGSCNDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6H3</accession>
    <accession>E9BQ35</accession>
    <name>A0A3S7X6H3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LDBPK_331060</name>
        <name evidence="20" type="ORF">LdCL_330016700</name>
        <name evidence="21" type="ORF">LDHU3_33.1640</name>
    </gene>
    <organism evidence="20 24">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20 24" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 24">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863930.1">
        <property type="nucleotide sequence ID" value="XM_003863882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6H3"/>
    <dbReference type="GeneID" id="13392327"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1640"/>
    <dbReference type="OMA" id="ATMWGRN"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000092">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000141">
        <property type="entry name" value="Putative calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="199"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="971"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAC5433305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBZ37247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1197" mass="129017" checksum="534DFE4868A7ECED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6X8</accession>
    <name>A0A3S7X6X8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330026700</name>
        <name evidence="4" type="ORF">LDHU3_33.2900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6X8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2900"/>
    <dbReference type="OrthoDB" id="273569at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="553" mass="57728" checksum="84214432B239A0A4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6Y2</accession>
    <accession>E9BQE2</accession>
    <name>A0A3S7X6Y2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Presenilin enhancer-2 subunit of gamma secretase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Presenilin enhancer-2 subunit of gamma secretase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Presenilin_enhancer-2_subunit_of_gamma_secretase_ putative/Pfam:PF10251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_10405</name>
        <name evidence="11" type="ORF">CGC21_37580</name>
        <name evidence="10" type="ORF">LDBPK_332120</name>
        <name evidence="8" type="ORF">LdCL_330028100</name>
        <name evidence="9" type="ORF">LDHU3_33.3050</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864037.1">
        <property type="nucleotide sequence ID" value="XM_003863989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6Y2"/>
    <dbReference type="GeneID" id="13392433"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330028100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3050"/>
    <dbReference type="OMA" id="LPWLWGL"/>
    <dbReference type="OrthoDB" id="524898at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5433416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP55487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="115" mass="13160" checksum="85F75E8D8A4F015B" modified="2019-05-08" version="1">MLVRGSFTLEKAESACQWYYRIGFFALPWLWAVVWLFFRHYEDESELIRWYVERAKRYSVSGGAVFVIVSVVFLFVIPPTSPIWVIAPFQDTFQWGYFAVNASEAAGAENAGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X717</accession>
    <accession>E9BPH6</accession>
    <name>A0A3S7X717_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_37455</name>
        <name evidence="3" type="ORF">LDBPK_332370</name>
        <name evidence="2" type="ORF">LdCL_330030700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864062.1">
        <property type="nucleotide sequence ID" value="XM_003864014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X717"/>
    <dbReference type="GeneID" id="13392458"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3410"/>
    <dbReference type="OMA" id="HVEYWYN"/>
    <dbReference type="OrthoDB" id="270654at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="311" mass="35544" checksum="8C3627F9212311ED" modified="2019-05-08" version="1">MNTRRKMIQAKPDVPSTHWHLMNEDFYPLFEADMRQHVEYWYNMAATGVQRDIFRRICNAIYRQDPATPDPTFNVAFTETVELEQVRLLLKNYGVVLSDNVGKPKTRVWLLHCGKSARDRNEFRSVFTGCQTTYERRSVMHADYVAPDPASYPDDRTHFMRSVDWTSLKTREAMLKLEAQRRANGGVMRSQLNKLSSTIADEQRRMNGDGKPMQRTTKPKNQFDGVNVLSSLGFDGVPAEEAVAQLKAKQNAHREAEWYYVDKDRSTVYKARPNKGPAAAAAASRPNRGEGGILASVTSEPMTRWVNKTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X785</accession>
    <name>A0A3S7X785_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330038700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X785"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330038700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4570"/>
    <dbReference type="OrthoDB" id="264900at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1224" mass="128111" checksum="A50AEC4D6CBC31FA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8F2</accession>
    <accession>E9BRG4</accession>
    <name>A0A3S7X8F2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin 2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Aquaporin 9, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Aquaporin_2_putative/GeneDB:LmjF.34.3850</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Major intrinsic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_20670</name>
        <name evidence="11" type="ORF">CGC21_27130</name>
        <name evidence="10" type="ORF">LDBPK_343660</name>
        <name evidence="8" type="ORF">LdCL_340046000</name>
        <name evidence="9" type="ORF">LDHU3_34.5910</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864525.1">
        <property type="nucleotide sequence ID" value="XM_003864477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8F2"/>
    <dbReference type="SMR" id="A0A3S7X8F2"/>
    <dbReference type="GeneID" id="13387404"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340046000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5910"/>
    <dbReference type="OMA" id="FWVGPIS"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000060">
        <property type="entry name" value="Aquaporin 9, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724:SF13">
        <property type="entry name" value="AQUAPORIN NIP1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="AQUAPORIN NIP2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5433964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ37843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP40272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="230" mass="24800" checksum="0C842176A697A26A" modified="2019-05-08" version="1">MLSEFLSQLVAEFVGTFLLVLTITLASVGVGTLAPIPIGFMLAAMCFTFGYISGAHFNPAISFAVFINRKMTLRRTVMYIVVQLAGSFCASLYASAIIGLQIPAPVANGDLANTWQVLLCELVYTFALTSVVLHVCFSRQRSNDFYGFAIGMTLMAAGFSVGGFTGGAFNPAVATGTQLVLCVYKNCDPLFYFWVYWIAPICGAFVASVIFQLLDTHESVPVVLGKEAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X958</accession>
    <name>A0A3S7X958_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350020800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X958"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2120"/>
    <dbReference type="OrthoDB" id="239554at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="578" mass="66216" checksum="07332DF099ED1E52" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9B4</accession>
    <name>A0A3S7X9B4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_350027900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2930"/>
    <dbReference type="OrthoDB" id="273029at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1307"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1436"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1753"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2123"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="970"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2957" mass="312110" checksum="657CC82FF955F31E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAQ4</accession>
    <name>A0A3S7XAQ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Major vault protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_360025000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAQ4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2550"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000004">
        <property type="entry name" value="Major vault protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000003">
        <property type="entry name" value="Major vault protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000004">
        <property type="entry name" value="Major vault protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.620:FF:000003">
        <property type="entry name" value="Major vault protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF12">
        <property type="entry name" value="VAULT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="10">
        <location>
            <begin position="346"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="15">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="14">
        <location>
            <begin position="482"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="12">
        <location>
            <begin position="553"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU83540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="876" mass="97501" checksum="3F713817D05555B0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB67</accession>
    <name>A0A3S7XB67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Swi5, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Swi5_putative/Pfam:PF07061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360038300</name>
        <name evidence="5" type="ORF">LDHU3_36.4380</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XB67"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4380"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8246" checksum="840E38A3923FBB99" modified="2019-05-08" version="1">MPIEEDVATPYQLLCWELSALPLAELLHRYNASRDLAQELIGLIAQHQDCTIAHVHRMLGVRTEAAPRGDDDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBP8</accession>
    <name>A0A3S7XBP8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360061800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBP8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360061800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7280"/>
    <dbReference type="OrthoDB" id="272682at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="487" mass="53253" checksum="A8586B7B7837C77D" modified="2019-05-08" version="1">MWPTFVQQSHTAAPAFHCSTCTCLLSARLVHMRQRRFSARVSGAASSAAVARDSAVKSHSRYWRRWRGFGIVSGCFVLCVVLYVCLGNSIMFQSSGQQLQRRRPGKYPVLAERDVVALEVATSQVANLATLPTLNDLVKSAAELGAVYAQVLEQVVAAQEVEDGGRVLRELGVSQNHLSSGCSSLRRAADVCYAKLKAMLLQEAHAELHMAPTSLVRTTYGWMLGNIYLYSAVLPEYYLLRDDSTSHALVLLRSINVLSWSPRVHTVPSSEMREPRAAVATYDLFNWSGGAACRRGLLSHVPHAKRFCESSFSSWSAVARRVAATYEELIVLHPTYAPLRLHYAISFAFLAMDTAADVAAGGTQALEGHPAKALKVIRSDRSKLERTYRHADAAHGPVLALLEAFLTPVALRTADQDAQLVAALREWGSCAEAQAALLEATSWPGGVFPGEYRAPLLRDAQLLHLLAKAQLHLGDDHAALQTLRLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBV8</accession>
    <name>A0A3S7XBV8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit beta, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360062100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBV8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360062100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7310"/>
    <dbReference type="OrthoDB" id="302453at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="735"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="845" mass="92199" checksum="B9B920E1EEF2C133" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJH4</accession>
    <name>A0A451EJH4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_020008900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJH4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0460"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU75639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="457" mass="48238" checksum="C1F213439BF2221E" modified="2019-05-08" version="1">MGRASKDKRDIYYRKAKEEGYRARSAYKLLQIHEEFNILDPAEIRTGAVDLCAAPGSWSQVLAQHFKMIGANLTAAAEGDSLPAQTPRVVAVDLQEMAPIDGVTLLQGDITSEVTAREIIRLLNAPTPTGVSLTDDEQQQPANSSFSSPAPSPALGASPRKADIVLCDGAPDVTGMHELDEYLQHHLLLAALHITTFVLRAGGCFLTKMFRGPNTAFLVAKSGLFFQQVRVVKPKSSRNASMESFLLCQGFRMPLGYVPRFVGAVAPAAASSAATGCSRGAASTSAGCGSRVEADNEQGMKGERSETATVSDGPLRASGFTPEAPLYCYDTTASFSHASDGGAAAAATVHDVAHHNQRTSCALADRVLAPFLSCGDLSGFDADMCYDRDEDADVLEPVQPPLQAPYLAAAAASPSQLAEVADGRDTEADASQKKKIRVESPTATAGRDSSTGGEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9B773</accession>
    <accession>A0A451EJ66</accession>
    <name>E9B773_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_010080</name>
        <name evidence="2" type="ORF">LdCL_010005800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857822.1">
        <property type="nucleotide sequence ID" value="XM_003857774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B773"/>
    <dbReference type="GeneID" id="13389776"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0100"/>
    <dbReference type="OMA" id="RVRCAEQ"/>
    <dbReference type="OrthoDB" id="244029at2759"/>
    <dbReference type="PhylomeDB" id="E9B773"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25681" checksum="753BC3C117946026" modified="2011-04-05" version="1">MPDASSTAVVAAPPSKERLGSSGGVLLPLAVAGAGLLCLWKAFQICSVPVHPRCVTVVYDTRRKTVLCTSADCEMRRGSLPRVSHFNASLYFGSALMYWSRTRLLVPPSSFFGVFTLPRSVLEEPGEPVNCAVEEVAVRDGSVNMMVTVFYTIPFDQVERYLAAVGPEPPNEVIGKAVAYVARVRCAEQSAGILLSKTRREAFMGPYKDHLTSKLMSEAAVLVRDVAVESVVLLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9Z2</accession>
    <accession>A0A3S7WQS2</accession>
    <name>E9B9Z2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUB domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_091060</name>
        <name evidence="3" type="ORF">LdCL_090016100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858785.1">
        <property type="nucleotide sequence ID" value="XM_003858737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9Z2"/>
    <dbReference type="GeneID" id="13392062"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1240"/>
    <dbReference type="OMA" id="VIHECIN"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="PhylomeDB" id="E9B9Z2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="312" mass="35299" checksum="A3A576D8E2688B37" modified="2011-04-05" version="1">MNAVKLPEEWETLCSTSDAEVIHECINGVFRRLLANLLLDFNNPKFRQVKKDNKALRRLTESLPAGFIEFLFSSIGFAKHEDAFIFEGSLESLKHGDTVLSCIEDIFGKERLQAAQCGLYRLRNLAIKKAENGLTQREMATATARLQRARPLSQEEDAKRQAQQGGTEKDVAEEHAVKEAVRKTLLNTGRVRNGFFEARDFSVRTMQHGRVYACTKKCPDHCVEAHWHLFTGRNILYSHLAHLSADGTRLLHLGPEHGYQYNSLPGSANFGKMIHFSEKLMDENGRLVHIKNDDKPVTACIYCGRAFAELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>E9BB18</accession>
    <accession>A0A3S7WRX0</accession>
    <name>E9BB18_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_120380</name>
        <name evidence="2" type="ORF">LdCL_120009400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859155.1">
        <property type="nucleotide sequence ID" value="XM_003859107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BB18"/>
    <dbReference type="SMR" id="E9BB18"/>
    <dbReference type="GeneID" id="13390176"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120009400"/>
    <dbReference type="OrthoDB" id="10401435at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7419" checksum="67CE35F80C353FC0" modified="2011-04-05" version="1">MTVLGDVQPNSTVASVYNGRRVLNESGCDSIIGLSGVSSRDSAPCHCAGRTHTSTRNQQRHAPRRVWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFB0</accession>
    <accession>A0A3S7WWJ4</accession>
    <name>E9BFB0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_211240</name>
        <name evidence="3" type="ORF">LdCL_210017500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860641.1">
        <property type="nucleotide sequence ID" value="XM_003860593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13386500"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1470"/>
    <dbReference type="OMA" id="GYDTSPC"/>
    <dbReference type="OrthoDB" id="267081at2759"/>
    <dbReference type="PhylomeDB" id="E9BFB0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1441"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1621"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1710"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1780"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1912"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1478"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1627"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1797"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1889"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2048" mass="215764" checksum="12C8215E6BA6D141" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFJ7</accession>
    <accession>A0A3S7WWT5</accession>
    <name>E9BFJ7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA uridylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_212110</name>
        <name evidence="4" type="ORF">LdCL_210026800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="1"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860728.1">
        <property type="nucleotide sequence ID" value="XM_003860680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFJ7"/>
    <dbReference type="GeneID" id="13386552"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2510"/>
    <dbReference type="OMA" id="FEPHSLG"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="PhylomeDB" id="E9BFJ7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000039">
        <property type="entry name" value="RNA polymerase II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000095">
        <property type="entry name" value="RNA polymerase II, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="3">
        <location>
            <begin position="39"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="382" mass="43066" checksum="9573E7508E7D6480" modified="2011-04-05" version="1">MDLGMCLLTRASTYRRNGGELGTSMSSKIAELSGRILSQQQYSQILEQRRWLQGLLKGVSLDMGAKEEEKSASPVVLPYGSIVSGTSFTDGDADYIVSFPIVSESTRQSGACVIARERQEKCLSDIFSHIRKCNSDVELHPQRIFRARVPIVQYVRKSAQESTKFDLSLSLDGLKNSLLLRHYMAGDPRLRLGVLGAKQWGREQQILNARRGWISPYALSIMYIHFMKDTGRTALSFDEEAVSQRVNAIVSTAAEAEGDISHVDELASILPLQEADISLVEKDVLDFFAFYGTPGGFDFDASVVDIRSRERFSTKDQWCQFLDQLDEKERWHLLGHEVILLRDPFEPHSLGRSVDFFRGEEIREKFRSAAVKKEPLSLFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHK1</accession>
    <accession>A0A3Q8INB5</accession>
    <name>E9BHK1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_250970</name>
        <name evidence="2" type="ORF">LdCL_250015000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861427.1">
        <property type="nucleotide sequence ID" value="XM_003861379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHK1"/>
    <dbReference type="GeneID" id="13388673"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1240"/>
    <dbReference type="OMA" id="KEMRIQW"/>
    <dbReference type="OrthoDB" id="273895at2759"/>
    <dbReference type="PhylomeDB" id="E9BHK1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="590" mass="63400" checksum="45A7B178E9DB82B9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJZ9</accession>
    <accession>A0A3S7X1U4</accession>
    <name>E9BJZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_282790</name>
        <name evidence="5" type="ORF">LdCL_280033000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862377.1">
        <property type="nucleotide sequence ID" value="XM_003862329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJZ9"/>
    <dbReference type="GeneID" id="13387113"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3770"/>
    <dbReference type="OMA" id="CRFIRYQ"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="PhylomeDB" id="E9BJZ9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="886" mass="96057" checksum="410CFEBC59691768" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKU5</accession>
    <accession>A0A3Q8IIS4</accession>
    <name>E9BKU5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_291470</name>
        <name evidence="6" type="ORF">LdCL_290020200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862566.1">
        <property type="nucleotide sequence ID" value="XM_003862518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKU5"/>
    <dbReference type="GeneID" id="13387302"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2140"/>
    <dbReference type="OMA" id="HYREHNH"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="PhylomeDB" id="E9BKU5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000835">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="235"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="663" mass="71014" checksum="8D26407282761F79" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>E9BM72</accession>
    <accession>A0A3S7X3T9</accession>
    <name>E9BM72_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LDBPK_303290</name>
        <name evidence="17" type="ORF">LdCL_300038500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863040.1">
        <property type="nucleotide sequence ID" value="XM_003862992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BM72"/>
    <dbReference type="SMR" id="E9BM72"/>
    <dbReference type="GeneID" id="13385749"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300038500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4380"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="PhylomeDB" id="E9BM72"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730289" description="glutamate--tRNA ligase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="46"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="354"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="458"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="594" mass="67907" checksum="37E840B161785653" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BP88</accession>
    <accession>A0A3S7X637</accession>
    <name>E9BP88_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_323380</name>
        <name evidence="2" type="ORF">LdCL_320039700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863749.1">
        <property type="nucleotide sequence ID" value="XM_003863701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BP88"/>
    <dbReference type="GeneID" id="13391275"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320039700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4250"/>
    <dbReference type="OMA" id="NHATRHT"/>
    <dbReference type="OrthoDB" id="272939at2759"/>
    <dbReference type="PhylomeDB" id="E9BP88"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="CDD" id="cd23677">
        <property type="entry name" value="RESC3_ARM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="673" mass="74569" checksum="882D894A7B6BE88F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPA7</accession>
    <accession>A0A3Q8IH43</accession>
    <name>E9BPA7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_323570</name>
        <name evidence="14" type="ORF">LdCL_320041600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863768.1">
        <property type="nucleotide sequence ID" value="XM_003863720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPA7"/>
    <dbReference type="GeneID" id="13391531"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320041600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4510"/>
    <dbReference type="OMA" id="KCDHNGF"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="PhylomeDB" id="E9BPA7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01036">
        <property type="entry name" value="ClC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF159">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="666"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="885" mass="96837" checksum="489D36C972329321" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPM4</accession>
    <accession>A0A3Q8IDZ5</accession>
    <name>E9BPM4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_332860</name>
        <name evidence="6" type="ORF">LdCL_330035700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864110.1">
        <property type="nucleotide sequence ID" value="XM_003864062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPM4"/>
    <dbReference type="GeneID" id="13392506"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4000"/>
    <dbReference type="OMA" id="DVMVCGA"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="PhylomeDB" id="E9BPM4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000081">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="459" mass="47232" checksum="F0406C867AAC5C50" modified="2011-04-05" version="1">MVTPLGVTAVDTWAAVCRGQSGCRPLIEAPYFLPGFLENDKMLSPQQKAAALEKLVAALPCKVAAFVQPPAEVGLAAGKVDKAVPAADPFAPTAHEPRALRLCARAVEEALADAALQLSEAVQDRCGVNIGMGIPSLADVTDVSAYLTGDAIATDAGHVHYSKVPPMFLPKILGNMAAGNTAIRHKLRGPIGSSVAACATGAHCIGEAALWIREGRADVMVCGAAEACITPVSVAGFTRMRALCTRFNDTPSSASRPFDITRAGFVMGEGAGVLILEALEHAVARAAPRVYAELRGFGISCDAHHVAVPHPEGLGARRCVEQALAEGGDVPASAVGYVNAHATGTIGDEVELMAIQQALRPSTAPSSPALHVSSAKGGLGHLLGAAGSVEAALTVLALHEQRAPPTANLTTSCLTREQQECGLVCIQGSTAQPMQSCEAVISTSFGFGGINTALLFTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR57</accession>
    <accession>A0A3S7X837</accession>
    <name>E9BR57_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_342590</name>
        <name evidence="2" type="ORF">LdCL_340033500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864418.1">
        <property type="nucleotide sequence ID" value="XM_003864370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR57"/>
    <dbReference type="GeneID" id="13392827"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340033500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4200"/>
    <dbReference type="OMA" id="CGIRRIP"/>
    <dbReference type="OrthoDB" id="277355at2759"/>
    <dbReference type="PhylomeDB" id="E9BR57"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="301" mass="33644" checksum="572111D92FE61BAD" modified="2011-04-05" version="1">MNPDDGSEAGSIAEPLPQEQITMLLNVQDFQEKVAQDPANLCCVIVTSTLCRHCGIRRIPYPKVAHPHSKTSSNEDGESEDEDADTDSDDGYGDEEDSQADGGAGHSARAGHFYRDIEEHLVHNRDTATQRRHTRFFHVCACMEEETCVDFLIAADPAYSLLNKQPTAHEMALLHKKAHHQLKELLNLLEVRSTPSMRLYLAGQPLRYSAMLSSCNDAAAPKDVTAETDVLQVSGANWIKWFQVLQNAVVVRNEVMRSYDTEEREKARAARAEARRQARRERRKQAAADEEEGDEEGAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I7X8</accession>
    <accession>E9BAP5</accession>
    <name>A0A3Q8I7X8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_30805</name>
        <name evidence="6" type="ORF">CGC21_0990</name>
        <name evidence="4" type="ORF">LDBPK_110570</name>
        <name evidence="2" type="ORF">LdCL_110010600</name>
        <name evidence="3" type="ORF">LDHU3_11.0640</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859033.1">
        <property type="nucleotide sequence ID" value="XM_003858985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I7X8"/>
    <dbReference type="GeneID" id="13389837"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0640"/>
    <dbReference type="OMA" id="TPHHFWQ"/>
    <dbReference type="OrthoDB" id="268386at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP39832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="132" mass="15423" checksum="ED599A2A8C08FEE9" modified="2019-04-10" version="1">MLRSTLTRRSGFSVKELYPYGVPRRTFPYREHQKQISLAPTAGGFYVTKHALGWPFQIPFEWLFYRSSVAFFVFCVAYDMLFGLPHPFMKEVPPGTPHHFFFGNAGGTPHHLWQYQDGWTVPNMSGGRRWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I877</accession>
    <accession>E9BB44</accession>
    <name>A0A3Q8I877_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_23685</name>
        <name evidence="6" type="ORF">CGC21_27460</name>
        <name evidence="4" type="ORF">LDBPK_120640</name>
        <name evidence="2" type="ORF">LdCL_120012100</name>
        <name evidence="3" type="ORF">LDHU3_12.0980</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812632">
        <property type="protein sequence ID" value="CAC5428311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000031">
        <property type="protein sequence ID" value="TPP44214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000046">
        <property type="protein sequence ID" value="TPP53913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859181.1">
        <property type="nucleotide sequence ID" value="XM_003859133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I877"/>
    <dbReference type="GeneID" id="13390168"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0980"/>
    <dbReference type="OMA" id="YLVMMGE"/>
    <dbReference type="OrthoDB" id="242539at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="164" mass="18854" checksum="B7B9657B95F31CA5" modified="2019-04-10" version="1">MQIILKSRNRFFAVALWSGATTVVMFWLVLRRTGFNTAYSRCTYLVMMGEYKQLLEPGTFPSNDRLPPHLRLDKPSYLDLRDTEIALPPVIDVSLSDRDQVRQLEGQLPSTERSDLHVHFGPIKSQTIIMTPSSNERYVRRRLGLSEKDRKNLEAEGQQAFAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8D6</accession>
    <name>A0A3Q8I8D6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAM91 N-terminus/FAM91 C-terminus, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_120021100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8D6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1700"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="396"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="3">
        <location>
            <begin position="749"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="870" mass="96607" checksum="F0AF13F228A4E7C0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8Q6</accession>
    <accession>E9BA72</accession>
    <name>A0A3Q8I8Q6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_23785</name>
        <name evidence="3" type="ORF">LDBPK_100240</name>
        <name evidence="2" type="ORF">LdCL_100007700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858863.1">
        <property type="nucleotide sequence ID" value="XM_003858815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8Q6"/>
    <dbReference type="GeneID" id="13392203"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0370"/>
    <dbReference type="OMA" id="DMGYNGI"/>
    <dbReference type="OrthoDB" id="263017at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="490" mass="54269" checksum="AB0E350268FA12A5" modified="2019-04-10" version="1">MSYRARQSELPKWFPQEEGVATNRISAPVTDDDLRRDFDSEVLELEHDKSVSRKERAARKKELLKRQAVVEEERERRAIAALETRLPRPDWYSSDDEAEFIQDGVEAEKISELRTQPEGGVGLVFCVVYTALSAVAFVFHFTSSCPIPWMRSESGRKYGVWRATGGGQPDLKVSDIHDCSYEMQFWQAAAAMSVLATFASLGAMISGVLLCVNKGHMGASFILSFYSFSFSLVSWALVVALYHSFRCGKGTFAGGVAHLDTGVALTLIGWVTHIAALTVLGVHFVKYWTRSINSGKTRAVRFIYVAVGVATIFLYSVGQAYTMWGKAFPQVEASVSLWHVRIYDRKTRLSTFLSRGAYKCAAITHRMKAAAALMIMSIIWLFFAVVLGTGACYKSQYIKISIVFGYASCIFALTAWITLLVTWNGRLCTGVTPSGQSSWTDMGYNGIPSGIQNAQINFSGYSLREGFGLIVGGWAISTVALIFNTVLWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8T8</accession>
    <accession>E9BAG9</accession>
    <name>A0A3Q8I8T8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab1 small GTP-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ras family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ras-related protein RabX1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ras-related_protein_RabX1_putative/GeneDB:LmjF.10.1160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_35530</name>
        <name evidence="5" type="ORF">LDBPK_101250</name>
        <name evidence="3" type="ORF">LdCL_100019500</name>
        <name evidence="4" type="ORF">LDHU3_10.1610</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000051">
        <property type="protein sequence ID" value="TPP52570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858959.1">
        <property type="nucleotide sequence ID" value="XM_003858911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8T8"/>
    <dbReference type="SMR" id="A0A3Q8I8T8"/>
    <dbReference type="GeneID" id="13389316"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1610"/>
    <dbReference type="OMA" id="FRMHQMS"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001483">
        <property type="entry name" value="Small GTP-binding protein Rab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="216" mass="24549" checksum="A5A903DDC3CB3974" modified="2019-04-10" version="1">MANPNTPGGDCDYIFKIIVIGDSGVGKSSLTVRLSEDVFYKDYASTIAIDFRMHQMNYMDKRVRLQIWDTAGQERFQSVATAFYRGANGVLLCFDLTHRPSFIHLEQWMERVKQQALPGIPCLLVGCKSDEARSSRQVTREEAVAWAQQHNMAFIETSAKEKENVQTAFQQITKFIFEDMKERNGKTPTAGDNAAGRSQSVNFDRQRSNRKESKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I937</accession>
    <accession>E9BAR4</accession>
    <name>A0A3Q8I937_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_30930</name>
        <name evidence="6" type="ORF">CGC21_0875</name>
        <name evidence="4" type="ORF">LDBPK_110760</name>
        <name evidence="2" type="ORF">LdCL_110013000</name>
        <name evidence="3" type="ORF">LDHU3_11.0960</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859052.1">
        <property type="nucleotide sequence ID" value="XM_003859004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I937"/>
    <dbReference type="GeneID" id="13389847"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0960"/>
    <dbReference type="OMA" id="NTYERRF"/>
    <dbReference type="OrthoDB" id="277516at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP39857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="205" mass="21966" checksum="BC3F21240E898C54" modified="2019-04-10" version="1">MAAADQLRYAAQMIELARSEEREDGNPLTAVRCYTTAMEVIASEASKRAATIESNEARRFFLFQVRSKLEMYHERAELLLQVANGSGLLDKPSFGNGDVSAFQTNYPPALFASAVANENSNTGNGGVGSCSTGGGFSVLGIPLQPQRMAPSALPTQTQSSYDDSKEPPMSCYLKPDDDATAEPPPVTPELDLDELMKNLGAPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9V6</accession>
    <name>A0A3Q8I9V6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger of a C2HC-type/Double zinc ribbon, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_180005600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9V6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0080"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001258">
        <property type="entry name" value="Uncharacterized protein TCIL3000_10_13860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF65">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="724" mass="77909" checksum="BCF62B752FC29CB9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA20</accession>
    <name>A0A3Q8IA20_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AATF protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200014000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA20"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1140"/>
    <dbReference type="OrthoDB" id="278618at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="4">
        <location>
            <begin position="294"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="3">
        <location>
            <begin position="523"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="601" mass="65448" checksum="C6B6F466B3F7BF41" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAW3</accession>
    <name>A0A3Q8IAW3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210016300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAW3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1330"/>
    <dbReference type="OrthoDB" id="266585at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="425" mass="45308" checksum="92120033E23301AB" modified="2019-04-10" version="1">MLSFPRLSALPARRCRTTAFHETPLASAARCHRQWHSTLAASNCGGIAAAPAARRADPCLATSSSSAQALSSHSCPTAAVLVDASDSALVTLPYCLAGVQEKVRAHLRSLLVQRLLAPLLTESLANFFGEQDSEGSSDTHPDRSGDAAAMTSAVVHSVTQSPSALRYLAFSHQHPQLRHPSWAPLWAASPSSNTPLSAAPRTSHAEPYAEIRADAKRPDEAAPDAFDVHVTLVDQDAAEALVRPCLGELAPLLGCRACGSFRAVTTAARNAVSAAFSPSTKAEAPPAQLSAPSPSLPPSLPVVTYWECCRVDSYIPSYVQVQAAVRHLLLRRRPTADYTANAWPAAAAALMSAPQLPRARPLALVAVVVPDHLTALYSEFLDMLERESGQWMQHQQHQRRGATCGGPVHLLLFNSKGLAREYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAY0</accession>
    <name>A0A3Q8IAY0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_210020200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAY0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1750"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056454">
        <property type="entry name" value="Beta-prop_IP5PC_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23754">
        <property type="entry name" value="Beta-prop_IP5PC_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IP5PC-F beta-propeller" evidence="6">
        <location>
            <begin position="66"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="601" mass="64541" checksum="7934FF325F0D1CB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB84</accession>
    <name>A0A3Q8IB84_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210023000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB84"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2030"/>
    <dbReference type="OrthoDB" id="545730at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026619">
        <property type="entry name" value="CEP95"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22545">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22545:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="821" mass="88719" checksum="0B8253A89AF60EDD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBM2</accession>
    <name>A0A3Q8IBM2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich repeat/Leucine rich repeat/Leucine Rich Repeat/Leucine Rich repeats (2 copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_200008300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBM2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0400"/>
    <dbReference type="OrthoDB" id="277458at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001016">
        <property type="entry name" value="Leucine Rich Repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF67">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="630" mass="67249" checksum="11B141912BD33213" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBP6</accession>
    <name>A0A3Q8IBP6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200022400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBP6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2140"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000831">
        <property type="entry name" value="PPR repeat family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001032">
        <property type="entry name" value="PPR repeat family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001033">
        <property type="entry name" value="PPR repeat family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF10">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115237" checksum="588600390F132BB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBZ4</accession>
    <accession>E9BBU9</accession>
    <name>A0A3Q8IBZ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LSD1 zinc finger containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">LSD1 zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_4730</name>
        <name evidence="6" type="ORF">LDBPK_140640</name>
        <name evidence="5" type="ORF">LdCL_140011900</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859435.1">
        <property type="nucleotide sequence ID" value="XM_003859387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBZ4"/>
    <dbReference type="GeneID" id="13391105"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0870"/>
    <dbReference type="OMA" id="GEANMNA"/>
    <dbReference type="OrthoDB" id="509329at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040319">
        <property type="entry name" value="LSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005735">
        <property type="entry name" value="Znf_LSD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31747">
        <property type="entry name" value="PROTEIN LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31747:SF3">
        <property type="entry name" value="PROTEIN LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06943">
        <property type="entry name" value="zf-LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger LSD1-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP46247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="226" mass="24280" checksum="A034E7644D9A9B94" modified="2019-04-10" version="1">MLFGQLVCYGCQRILTYPLGAVSCRCRLCDRVNAAENLQIRCTTCGQELHAPINTLALLCPCCGTVTDIPEELLPPLPSCVDLGGGEGTEKVIYVSHPTLPPRPRPNGEANMNAASLLGSRRPSTHLRGEGRRRSASFARRRFSRQEREGTAAQGNKEETIVDADADGAREAGGAHSADGKRRDTIGPISPDQAYVSSAVSESSRRAQRVAPSRLAPTVMIATRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICN5</accession>
    <name>A0A3Q8ICN5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex component Sec10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_230014600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICN5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1100"/>
    <dbReference type="OrthoDB" id="272443at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="3">
        <location>
            <begin position="789"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1199" mass="131822" checksum="A88068BCB152187E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICP7</accession>
    <name>A0A3Q8ICP7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Haemolysin-III related family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_170005200</name>
        <name evidence="9" type="ORF">LDHU3_17.0040</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICP7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0040"/>
    <dbReference type="OrthoDB" id="10266771at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561:SF2">
        <property type="entry name" value="HAEMOLYSIN-III RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561">
        <property type="entry name" value="HAEMOLYSIN-III RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5429038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25814" checksum="1CC40CB296280438" modified="2019-04-10" version="1">MRVGESPAILFITTVLSHVALLPTLHFFYRRKYIFELCCASFGFLASFMYHTTESFGTSIFLTEVEWHRLDNVGVISIMGIWYVYLCCFQNPYVDMSCKCFCIFFTLVVQQKNPWDVRFTISPILFFTLFPVVKHCLVEQRLPPFSARHLGCGVFLFFFAIIFFFLGLNKRADRYRMYHGAWHFFGGLSSFFLWEMVKTPGCTGSYGIQRRDCPLRGDTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE74</accession>
    <accession>E9BIX5</accession>
    <name>A0A3Q8IE74_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_33175</name>
        <name evidence="5" type="ORF">CGC21_31265</name>
        <name evidence="3" type="ORF">LDBPK_270410</name>
        <name evidence="1" type="ORF">LdCL_270008900</name>
        <name evidence="2" type="ORF">LDHU3_27.0490</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861898.1">
        <property type="nucleotide sequence ID" value="XM_003861850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE74"/>
    <dbReference type="GeneID" id="13389159"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0490"/>
    <dbReference type="OMA" id="DMWQLKA"/>
    <dbReference type="OrthoDB" id="271058at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="140" mass="16158" checksum="57871F76227AD93D" modified="2019-04-10" version="1">MNSTTTAQFEAAWCEVERQQRERLSASTERLNAEVERELTLLLAGVRDALTEDQRDIQSEFDKLIRMVEQFQQGVDMWQLKAKSSIKMIEEKQRNFALLVEETSIRAAANRRDSIDRLQKRAIETEAHCQQLIAAASKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE96</accession>
    <name>A0A3Q8IE96_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180014300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE96"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1160"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930:SF2">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G04250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930">
        <property type="entry name" value="YALI0C12947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="117874" checksum="9A3C4C2CD0E8508D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEE2</accession>
    <accession>E9BKZ5</accession>
    <name>A0A3Q8IEE2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fungal lipase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_28505</name>
        <name evidence="3" type="ORF">LDBPK_291980</name>
        <name evidence="2" type="ORF">LdCL_290025700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862616.1">
        <property type="nucleotide sequence ID" value="XM_003862568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEE2"/>
    <dbReference type="GeneID" id="13385319"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2830"/>
    <dbReference type="OMA" id="RAPNPIN"/>
    <dbReference type="OrthoDB" id="239042at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61189" checksum="5E138EC638D8F3C3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEF0</accession>
    <accession>E9BR17</accession>
    <name>A0A3Q8IEF0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="3">2.4.1.132</ecNumber>
            <ecNumber evidence="3">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_26390</name>
        <name evidence="6" type="ORF">LDBPK_342190</name>
        <name evidence="5" type="ORF">LdCL_340029600</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="3"/>
    <dbReference type="EC" id="2.4.1.257" evidence="3"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864378.1">
        <property type="nucleotide sequence ID" value="XM_003864330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEF0"/>
    <dbReference type="GeneID" id="13392787"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3650"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000236">
        <property type="entry name" value="Putative dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="314"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ37696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="550" mass="60559" checksum="E8B7587A2C08BA2B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEL1</accession>
    <name>A0A3Q8IEL1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280018400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEL1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1740"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44743:SF10">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44743">
        <property type="entry name" value="PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="470" mass="50962" checksum="E679CB72AFA29512" modified="2019-04-10" version="1">MESKASLPPHYECLGVDPSINSVDLARQYKKLSLQLHPDRAAYRDDAANEVHVQERYQRITEAYAVLSDPEKRRAYDAKHGVNFQSRLARLQAVIGQHNTMAMQRSAMGRKTTDSASTSSPTTDEHGAQHLHAAPHKDSAERTVGDDDEEDYDPNDVLAPPRGALHQAGSSCFYSGDSCDADGDGDYIARLFSLNLRVGAEAAPKTRNGVPVAQYQAITLTRALSSPASPYASTWGLVFEKNELVGLDGEYLEELERIAGLAAVPFPSSVQQINDTMVLPTTDVPRLLSRLYEAESTRSSAVSPVTGQTASTNKDARSGQSKKVCEVCVEAPTDSSLSSPTEHLHMVLAYSTVTYDLVGEVHLLGDDDVISRLVPSWCVAPQLSLLMPDATVLSVNNTHVRSAAELRAALRAAVLDGEDEDVMQAVKRARKSRAVVVEFCQLPFLCSCSSLENVSLSLPPTTSTRPRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF17</accession>
    <name>A0A3Q8IF17_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330032900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3680"/>
    <dbReference type="OrthoDB" id="267643at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1641" mass="171328" checksum="E1F9BE26187E2A26" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF55</accession>
    <name>A0A3Q8IF55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_310007200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF55"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0270"/>
    <dbReference type="OrthoDB" id="262238at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20789" checksum="A5348D7BAEB924A5" modified="2019-04-10" version="1">MECLIFAARYQPEARTLEFELTDAPLVDAVTDVTVTPCGAAAPLWKTPATQQGLFYGRNKFILDRPLLFADDRIALVCCVRVRQQRPSTLAALASDVLCGSADGSAVHCAGPQDIREYAMLLTEAPNTSRCDVHNNAFVYLTSQALPPIMAATSTTMVSPLPPEPPITHLTCARERSPPSSLPALSALALCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF74</accession>
    <accession>E9BNB4</accession>
    <name>A0A3Q8IF74_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_33380</name>
        <name evidence="5" type="ORF">CGC21_19635</name>
        <name evidence="4" type="ORF">LDBPK_320090</name>
        <name evidence="2" type="ORF">LdCL_320005800</name>
        <name evidence="3" type="ORF">LDHU3_32.0140</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863428.1">
        <property type="nucleotide sequence ID" value="XM_003863380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF74"/>
    <dbReference type="GeneID" id="13390003"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0140"/>
    <dbReference type="OMA" id="RRFCKFW"/>
    <dbReference type="OrthoDB" id="271784at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="304" mass="34646" checksum="17081D8AACA49061" modified="2019-04-10" version="1">MGGSSDTIGVRTKHDREEEERDRKLIERIMEENQNPFQTLVDPLLEQASYVYNTYLYASGVMFLTLSFWGAYPSFVRFRHAHIFRYRRTQLSFRRGLFATEHMPKWNKNRLQRIVVPPLPTSDLVVVGSAAASPVHPTLYSPSAATSNVSVVAAADTAVTARPASNLDRRFDVMELSATRTPHGSFGAGDTEKSERALSRELQSINRDFFGPQSRLFHRPIQENASTGDLRQRLRAAVTTAKAVVVLVENHRTVRSIPEGWEVWWVSEPEARRRRFCKFWLGGLVCARAFQDLMDMPDMPDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFC1</accession>
    <name>A0A3Q8IFC1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_310010900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFC1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0770"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="14">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU81240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="626" mass="68401" checksum="C427641A69642E3E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFT3</accession>
    <accession>E9BRD2</accession>
    <name>A0A3Q8IFT3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeats (3 copies) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (Many copies), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ankyrin_repeats_(3_copies)/Ankyrin_repeat/Ankyrin _repeats_(Many_copies)_putative/Pfam:PF12796/Pfam:PF13606/P fam:PF00023/Pfam:PF13637/Pfam:PF13857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_20820</name>
        <name evidence="8" type="ORF">CGC21_26980</name>
        <name evidence="7" type="ORF">LDBPK_343340</name>
        <name evidence="5" type="ORF">LdCL_340042800</name>
        <name evidence="6" type="ORF">LDHU3_34.5520</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864493.1">
        <property type="nucleotide sequence ID" value="XM_003864445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFT3"/>
    <dbReference type="SMR" id="A0A3Q8IFT3"/>
    <dbReference type="GeneID" id="13387372"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340042800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5520"/>
    <dbReference type="OMA" id="AGWHETV"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU82701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5433932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP40242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP46764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="341" mass="36986" checksum="7C45DF919D3017EE" modified="2019-04-10" version="1">MSFEDVILRNDVAGVRAFFNAVAKNAVNAVNGSGYVPLYFACMKPSVSPEVIKELVQLGAAVDGRGTDGETPLYISVYNHRLDVAKYLIARKADVNAVNGPHRETALHVAARCGFADILSFLLSAGADLNMRNARQETPLYVAAQAGRHDTVYLLLEADANAALANEDDKTPLHIASEKEYKHVVVLFKAARADLKHAKSLADTEWRLRPEPMMSSDQMLDKAAADQQFAAAVRRRSLAGAPAPDTKPMEVVEIKVPEPQVRRQNPLTGESYGPCRSLEEVGYDSPPPIPKELQNRPPARLSRIGGTSMVVGTGTEEGGREPIRIDSIGGDGVEYYAPPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFV3</accession>
    <name>A0A3Q8IFV3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300039400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFV3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300039400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4480"/>
    <dbReference type="OrthoDB" id="267291at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="390" mass="41531" checksum="1A2C5C111D35B026" modified="2019-04-10" version="1">MQRLVLSRRNLDGCSNTPAIVVTEVYVGGTGAQPKAEIFAQDCVTQVVFVKEEVIYMRLKGMSAFAAPSRLASPPPPPQQTNGSSTTCGAIAACSDHAAQPTATETASSLLKESATLKNEDELVAEVKRSASKTPAPPPAAAKSAVTHATTLKAISDGAATAAAPTTAEPPVPKAAAPRRRPGWGPEAHELFPENYMSTPGKRPRTVRSEKKTTLAQAAKRSKTESNNAAVVSMKAGWGEEPSDKRVPADKHLGWGPEASKLFADNYVSSPEKLARLQRSQRRVMNESAESAAPAGAAALTKSALKAPVSRTLQYPTADTEEGRTTVGHAVDDAIVVDETSPTVELPKGWGRESLKFFDPNTYCDDPAKARLLPNMDYSRSRRHRRPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG80</accession>
    <name>A0A3Q8IG80_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_11330</name>
        <name evidence="4" type="ORF">LdCL_310026100</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3260"/>
    <dbReference type="OrthoDB" id="261629at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF613">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1373" mass="150283" checksum="F3369EC64449089E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGJ5</accession>
    <name>A0A3Q8IGJ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_250016000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGJ5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1360"/>
    <dbReference type="OrthoDB" id="259759at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11052" checksum="F654FE6BB0889416" modified="2019-04-10" version="1">MYSPELEWLLGSATPVQQRRELKASAATGCSVPASDSLHRAAKLDSTVVDGHAMPPRPPTAPSAQRSTCTPEFYNNVQVIGGLPQRGPRAPTDTFSAMPCRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGZ4</accession>
    <name>A0A3Q8IGZ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">As/Sb Reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320034700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGZ4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320034700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3640"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01443">
        <property type="entry name" value="Cdc25_Acr2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000116">
        <property type="entry name" value="Sb(V)-As(V) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14407" checksum="0C7DC3FBAEADF129" modified="2019-04-10" version="1">MANYTYMKPEELVEVLDNPDSLTKAAVIDCRDSDRDCGFIVNSISMPTISCTEEMYEKLAKTLFEEKKEIAVFHCAQSLIRAPKGANPFVLAQKKLGYVLPAVYVLRGGWEAFYHMYGDVRPDLIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHB3</accession>
    <accession>E9BAI0</accession>
    <name>A0A3Q8IHB3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_35470</name>
        <name evidence="4" type="ORF">CGC21_23235</name>
        <name evidence="3" type="ORF">LDBPK_101380</name>
        <name evidence="1" type="ORF">LdCL_100021000</name>
        <name evidence="2" type="ORF">LDHU3_10.1760</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000051">
        <property type="protein sequence ID" value="TPP52558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858970.1">
        <property type="nucleotide sequence ID" value="XM_003858922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHB3"/>
    <dbReference type="SMR" id="A0A3Q8IHB3"/>
    <dbReference type="GeneID" id="13389483"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1760"/>
    <dbReference type="OMA" id="YNCSIPF"/>
    <dbReference type="OrthoDB" id="275444at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015045">
        <property type="entry name" value="MPT-1-like_LmxM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036:SF2">
        <property type="entry name" value="DUF1861 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5428094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="321" mass="35858" checksum="583F75D8251C3AE6" modified="2019-04-10" version="1">MGLLNTKPCSLIPAKEAFEREKKIYGKAILSFDGVNGYDVYNCSVPFTYDGKTYIFGRVEKKDEWVHSNSILFEKVGENRYRRHPTSITYNLEDPFVVKIHGEMVFGGTHVTKNGGKVSDYRCEFYHGTPLNLKYFASGPSKMKDIRLVELADGKIGIFTHFRTEGSCLTGFATIDKIEDLTVEVINSAKLINHRPFGDAWGGPSQVYLLSSGLLGCISHHGYLLDQKDDIQLRIYACTSFVFDPATYDVYNFKIIGTKGCFPPCEPKLPHLADCAFVSGIEMRDDGKCNLYSGIGDVAEGYIVIDYPFEGYGNIVSDVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II01</accession>
    <name>A0A3Q8II01_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_360070400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II01"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360070400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8350"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="77"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="572"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="976" mass="104600" checksum="E0336A929DA62192" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II82</accession>
    <accession>E9BR22</accession>
    <name>A0A3Q8II82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal protein L35Ae family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosomal protein l35a, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribosomal_protein_l35a_putative/GeneDB:LmjF.10.00 70/GeneDB:LmjF.34.2470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_21340</name>
        <name evidence="13" type="ORF">CGC20_35910</name>
        <name evidence="11" type="ORF">CGC21_23885</name>
        <name evidence="10" type="ORF">CGC21_26415</name>
        <name evidence="9" type="ORF">LDBPK_342240</name>
        <name evidence="5" type="ORF">LdCL_100005700</name>
        <name evidence="6" type="ORF">LdCL_340030100</name>
        <name evidence="7" type="ORF">LDHU3_10.0110</name>
        <name evidence="8" type="ORF">LDHU3_34.3730</name>
    </gene>
    <organism evidence="6 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="19" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="20" key="6">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 20-144</scope>
    </reference>
    <reference evidence="6 15" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="10">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="11">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5427959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000045">
        <property type="protein sequence ID" value="TPP51563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864383.1">
        <property type="nucleotide sequence ID" value="XM_003864335.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="g=1-144"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="j=1-144"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="g=20-144"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II82"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3Q8II82"/>
    <dbReference type="GeneID" id="13392792"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3730"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000003">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18 19 20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5427959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5433808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP40129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP46670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP51563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="144" mass="16454" checksum="2F46BC7A633C5675" modified="2019-04-10" version="1">MTTSKVHSQRSKKLHQLSAKTSRVNRNRKAPRLYMKGTLAGYTRGLHGQTKQTALVRVENVNTREDATWYVGKRVCYVYHGKKVKRCVRWSKAPARRSTTRALWGRVTRPHGNAGMMRVKFNGASVPASAIGRRIRVYLYPSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIN7</accession>
    <name>A0A3Q8IIN7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DNAj, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350046000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIN7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350046000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5310"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="386" mass="42808" checksum="6C3FB00269D9F5C4" modified="2019-04-10" version="1">MLKDYYAILDVLPHASGEEIRRAFKRLALQFHPDKVGSGAATELTSTVDADRHRVAAKRDENASANASVARSNAAAASCQPLSRDFTDIQEAYEVLGDVARRYLYDMNYQELLAVQQQRQQEERKRCDSHARAVAEAARQARERERLQQQQQSPQPRNINTFSTMESIAAGGLRANAPGSSPPQHGAPHTLGRGAEDIGAASPTLPPDDAPQRRQPCQKLAPAEKEKDGDCSLRDLERDAGGGGGLSQARCCFTAPTRPREVGSRPKECRAKRHGCERDTNERLTSSHTQRRLSCADTKHARQHMAATVPAMFVLSSSLPFSWGETSAQTCPSVVEPSGSRGRQWHRHTAPRNDGETEEPELPMEYYYQRSIERTLRVFFSVPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ40</accession>
    <name>A0A3Q8IJ40_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350011500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0800"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="2">
        <location>
            <begin position="2778"/>
            <end position="2881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2166"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2884"/>
            <end position="2959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3281"/>
            <end position="3344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4079"/>
            <end position="4105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4145"/>
            <end position="4180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2887"/>
            <end position="2908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2936"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3290"/>
            <end position="3306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3307"/>
            <end position="3322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="4163"/>
            <end position="4172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4180" mass="457089" checksum="45670F1472BB5DAC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJG5</accession>
    <name>A0A3Q8IJG5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_4080</name>
        <name evidence="2" type="ORF">LdCL_170015200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJG5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1340"/>
    <dbReference type="OrthoDB" id="273498at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="596" mass="60293" checksum="B13D7BBC6B56FA1C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJH2</accession>
    <accession>E9BP31</accession>
    <name>A0A3Q8IJH2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">L-Lysine transport protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Transmembrane amino acid transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_20945</name>
        <name evidence="9" type="ORF">LDBPK_322800</name>
        <name evidence="8" type="ORF">LdCL_320033900</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863693.1">
        <property type="nucleotide sequence ID" value="XM_003863645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJH2"/>
    <dbReference type="GeneID" id="13391218"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3530"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="94"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="486" mass="52175" checksum="E8C018EC567162BD" modified="2019-04-10" version="1">MSGANHHNHSSDSDDRSAPLPEELATHYPYTEASGNVLAADSAAVTKMKGTAGESYSSSSVDGLAVPQANSTGVRGAIERVYSIIPHGGLVANIYNLASATLGAGIVSVPSGFHQSGMVVSVVLLAVVCACTIYSIRLLGQAKLKTGLRSYEEMARGMLGRGWDYFAAFLMLMFCWGTCVGYVISVGDLLSPMLDGPNTNAFFKTDNGHRILIGLIWFVGMFTLSLPKEINSLRYASVIGVSFVVFFVICVIVHSARNGLKNGIRKDIVLANNGMPAVNGLTLFIFAFICQVNVFEIFDEMQKPTLGRMTRDATISMLVVALLNFFSGFFGYCDFGAEVDGSILLLYRPLEDPLFMISYIGICIKLCVGFAICIQPSRDAIYYCLGMGKTSDVKDWLNWIVSGFLALAALICGLFIPSINIVFSLLGGICGGFLGFMFPAYFFIYSGGFTLKKVGILNYLGCIVLIVGGVVAVVFGTAVAIFSEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJZ1</accession>
    <name>A0A3Q8IJZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSP1 C-terminal conserved region containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350055500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJZ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350055500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6620"/>
    <dbReference type="OrthoDB" id="271183at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF4">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="150"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="280" mass="31019" checksum="5DCA37E6FFF4924F" modified="2019-04-10" version="1">MMSVTSSQLSVSCVKKRVKVYRHEPYAASLITPASPAEAALVCCHQRSPKSPASSYATSSPARSILDAALPSAQVAAYPSHHAAASLALPMPMAHPAHTAVWVAFKYGRKPFVAAFQVCIGEMVIVEGDRGIDLGIVDDACTTPLPEKVLFILRRATAEDTTQHHRRTVKEQEALQTMRSLATQVHCPTHVEDAMFQLDGKKITVIISRASRSFVDFRRLQRSLFDVYRCRIWFAYLDEIQETMSTEVTRPLRRGQRRCSSSNEARDKKILPTASCTAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK52</accession>
    <accession>E9BT96</accession>
    <name>A0A3Q8IK52_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_360370</name>
        <name evidence="8" type="ORF">LdCL_360008550</name>
        <name evidence="9" type="ORF">LDHU3_36.0490</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865153.1">
        <property type="nucleotide sequence ID" value="XM_003865105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK52"/>
    <dbReference type="SMR" id="A0A3Q8IK52"/>
    <dbReference type="GeneID" id="13388039"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360008550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0490"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7487" checksum="350CB6CA0E6AEEF2" modified="2019-04-10" version="1">MHLRVYMVDGKRVYTLKKVDPEGKPTLSAHPARFSPDDKFSRHRVTIKRRFKVLPSERRLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK65</accession>
    <name>A0A3Q8IK65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 2C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360010500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK65"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0720"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000064">
        <property type="entry name" value="Protein phosphatase 2C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="298" mass="32612" checksum="47F0349A48777C24" modified="2019-04-10" version="1">MGDMLAKPETQKFSTVFETSHLRVGCCSMQGWRKSMEDAHVAQLNLNGNKDQAFFGVFDGHQSDEASRYCRAHMLDELLKNIAIYKDDVAKAFEVSFQEVDKQICKKFVSSGTTANCVYLSNQQIVCANAGDSRAVLYRGGKAVPLSVDHKPSVPAEEARIVAAGCHVENGRVNMTLAVSRALGDVDFKSCAAKSWVDQAVTACPDITVTPSRSDDEFIVIGCDGIWDVLSNEECCELVKTLIQNNDIDKNGHPVAVDISLVCEQVLDRCLAQSNSVKAGTDNMTIIVVEFKPPFFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKX0</accession>
    <name>A0A3Q8IKX0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340019900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKX0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2150"/>
    <dbReference type="OrthoDB" id="240175at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="346" mass="36810" checksum="C564D3CEAEB67407" modified="2019-04-10" version="1">MWGFEAYAEGLSTTPNIHGAHLTGVAPQEGEAAPLAPPRYLWKKNRNNYLFDAQGKLLGAAETHSPTIWRTHHAFSGRCALVNPTAPVTGGAAAQSFGAPGWAEQAWTAYQSWSVGFRLSSTTTDEPHILLSVAPAYFPNLVSATGEIRKADAATLASLPCAPSAEEEVIYNKRMLETPLIWEEPYALSVECTTHGVFLWSDHWGIFGRKIADRCLEARQDNVRQSGIATLPSPDPSPSSAAAGEELALVAYDAALRLRWNAAGPGSKSSTDGGSARAVAPTLSVELKTSGDAAAGGAAPTCEEKVGEELWQHLIDLPLSLDEVACKAAFRPYVTLMEGGDAVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILA5</accession>
    <name>A0A3Q8ILA5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vps54-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360072200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILA5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360072200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8570"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="7">
        <location>
            <begin position="877"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1195" mass="130343" checksum="1F1E386805B2DF52" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILI0</accession>
    <name>A0A3Q8ILI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Y113g7b.23 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360081300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILI0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360081300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9180"/>
    <dbReference type="OrthoDB" id="273724at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="362" mass="38535" checksum="41E878E675D774B7" modified="2019-04-10" version="1">MSLSNKREVREYVKLVLQPYEENSHIDVEDMKVLTREASDAVVTLPATPATVATAALTALQSLLSSRADVKPEVLEAVARALEASSVTAEQATASAASSHESGTATQGMASGSGTSSTAPNATTLSFSAFKARMAKKRDELKAERDTVAEVTSTATTHVESTTAAPPADSSPKVKKEEVLTTTVGTDPTESRNLSNQPSAAPTPSLRPSTAPAPSSIPDLAEEAALSRERDDVSSEQPPAKVEKKETFLFSALPDPDEEFDLYADLTPLSRGRGRGRGRGRGRGRGRGGPPYFYPTHNPYNSLNPHHHHGAPPPSHQCGGAPPPSHYHYGAPPPPQHHHYDAPPPHAYRGGYGPNTSYQRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILJ7</accession>
    <name>A0A3Q8ILJ7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340047600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILJ7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340047600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6120"/>
    <dbReference type="OrthoDB" id="271171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51845" checksum="FD2448F2222750D5" modified="2019-04-10" version="1">MDFSLTMSAAPHRLWYIDGDVVKVRVSLTCVPGAASGTQMEMAPLQRVPRHNYFSVDSTEAESRETDVRVRPLEVELLGLVELDTSVVKPINWPAAVSEEEIAVSPRPGRSRSAVIYTLYRTGKKTLQEDMHLKRYECAALEFVFRLPEGCPPTFKGRGTDYRHDITISATWYPVRSSASAKAAKPHICKVKVPLVVFNSVAAVAQLPLLSLFPLPPNSALVAKDFHFQASPLAAVPTPWLAAPLMDVMHPQQAQLRTSLTVRHDAKATMQSSLAAQRQPLSLMIPCGGVNVLQVHLHSSCVPLGEYLQGSLTVLQTRQRSCDSAAGPGAQRKQDTEAPVPVSVTATLELLECVTPECALATSDASVTDAKEHGMENFVCTHRRVIDHAEFCVLDTPCVPFEFSLPVGLVPASTITDITSFLWQLRVVVMVVPRKTLARTAAPGVGQLGPLLAPVAGVFPLLVMPPSVPFKVRQGAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IN05</accession>
    <name>A0A3Q8IN05_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar attachment zone protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340012700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3880"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056615">
        <property type="entry name" value="FAZ1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23404">
        <property type="entry name" value="FAZ1_C"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="4">
        <location>
            <begin position="419"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="846"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="902"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="958"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1168"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1224"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1280"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1322"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1378"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1420"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1532"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1630"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1672"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1728"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1784"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1840"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1882"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1938"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="1994"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2036"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2092"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2148"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2204"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2260"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2316"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2372"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2428"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2484"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2540"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="domain" description="FAZ1 C-terminal region" evidence="5">
        <location>
            <begin position="2596"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="4">
        <location>
            <begin position="2816"/>
            <end position="2865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="836"/>
            <end position="2680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="556"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="675"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="899"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1165"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1375"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1473"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1529"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1571"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1627"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1725"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1781"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1837"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1879"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1935"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1991"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2089"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2145"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2201"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2257"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2313"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2369"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2425"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2481"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2537"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2593"/>
            <end position="2644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2866" mass="321193" checksum="BCAA3649557F67B2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IN41</accession>
    <name>A0A3Q8IN41_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350056500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IN41"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350056500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6770"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF90">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="520"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="741" mass="80104" checksum="479AED8AD85BE595" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPG4</accession>
    <accession>E9BIN9</accession>
    <name>A0A3Q8IPG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32420</name>
        <name evidence="3" type="ORF">LDBPK_262280</name>
        <name evidence="2" type="ORF">LdCL_260028500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861813.1">
        <property type="nucleotide sequence ID" value="XM_003861765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPG4"/>
    <dbReference type="GeneID" id="13389060"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2980"/>
    <dbReference type="OMA" id="YITFHGE"/>
    <dbReference type="OrthoDB" id="243628at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="267" mass="29358" checksum="5984D04F6DDEFE88" modified="2019-04-10" version="1">MRGRTLTLLVRDALNAGSSMTLGSKGMRPSPEAHRRRMPWTAAKEYVPGVVLNSKEKLVLDGTQLVELDHIDRASQVDPLEVLKAAVATRAYNTSTGFNIFQLASQTRFHGRGQKFFREEWRQGTYEKYVTLAAIDFDREGSKGTAYGYITFHGESTTRPVEIHYADTPGWQMDYDEAAAVPFDAAVPPPPSIGTEVPVDPSTYRLKAYPFYDAPNPPEFVERLLKDRGVLPDLPMDASAPAENAAAASADGARADGSHHYEPKGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVH0</accession>
    <accession>E9BSQ8</accession>
    <name>A0A3Q8IVH0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_14810</name>
        <name evidence="13" type="ORF">CGC21_7390</name>
        <name evidence="12" type="ORF">LDBPK_353880</name>
        <name evidence="10" type="ORF">LdCL_350043900</name>
        <name evidence="11" type="ORF">LDHU3_35.5050</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="8">
        <citation type="journal article" date="2020" name="J. Med. Chem." volume="63" first="10773" last="10781">
            <title>Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.</title>
            <authorList>
                <person name="Nagle A."/>
                <person name="Biggart A."/>
                <person name="Be C."/>
                <person name="Srinivas H."/>
                <person name="Hein A."/>
                <person name="Caridha D."/>
                <person name="Sciotti R.J."/>
                <person name="Pybus B."/>
                <person name="Kreishman-Deitrick M."/>
                <person name="Bursulaya B."/>
                <person name="Lai Y.H."/>
                <person name="Gao M.Y."/>
                <person name="Liang F."/>
                <person name="Mathison C.J.N."/>
                <person name="Liu X."/>
                <person name="Yeh V."/>
                <person name="Smith J."/>
                <person name="Lerario I."/>
                <person name="Xie Y."/>
                <person name="Chianelli D."/>
                <person name="Gibney M."/>
                <person name="Berman A."/>
                <person name="Chen Y.L."/>
                <person name="Jiricek J."/>
                <person name="Davis L.C."/>
                <person name="Liu X."/>
                <person name="Ballard J."/>
                <person name="Khare S."/>
                <person name="Eggimann F.K."/>
                <person name="Luneau A."/>
                <person name="Groessl T."/>
                <person name="Shapiro M."/>
                <person name="Richmond W."/>
                <person name="Johnson K."/>
                <person name="Rudewicz P.J."/>
                <person name="Rao S.P.S."/>
                <person name="Thompson C."/>
                <person name="Tuntland T."/>
                <person name="Spraggon G."/>
                <person name="Glynne R.J."/>
                <person name="Supek F."/>
                <person name="Wiesmann C."/>
                <person name="Molteni V."/>
            </authorList>
            <dbReference type="PubMed" id="32667203"/>
            <dbReference type="DOI" id="10.1021/acs.jmedchem.0c00499"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 30-253</scope>
    </reference>
    <reference evidence="11" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864967.1">
        <property type="nucleotide sequence ID" value="XM_003864919.1"/>
    </dbReference>
    <dbReference type="PDB" id="6TCZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="I/i=1-253"/>
    </dbReference>
    <dbReference type="PDB" id="6TD5">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="I/i=30-253"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVH0"/>
    <dbReference type="SMR" id="A0A3Q8IVH0"/>
    <dbReference type="MEROPS" id="T01.A02"/>
    <dbReference type="GeneID" id="13387844"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350043900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5050"/>
    <dbReference type="OMA" id="GTQVDLC"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="19 20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5434410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ38287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP47948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6TCZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6TD5"/>
        </source>
    </evidence>
    <sequence length="254" mass="27590" checksum="305B0AE0BE4E1341" modified="2019-04-10" version="1">MPGFNFENVQRNLSLENEGYSAPRTLKTGTTIVGVVYKDGVVLGADTRATEGSIVADKCCRKIHYMAPNIMCCGAGTSADTEAVTNMVSSHLALHRLETGKQSRVLEALTLLKRHLYRYQGHVSAALVLGGVDVEGPFLATIAPHGSTDRLPFVTMGSGSIAAMAQLEVAYKDNMTCEEAKELVTSAIHKGIFNDPYSGTQVDVCVITKDKTELMIGYDTPNKRMHPRQEVMLPPGTTPVLKEEIRHLVDIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H591</accession>
    <accession>E9B7Z2</accession>
    <name>A0A3S5H591_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_2575</name>
        <name evidence="8" type="ORF">LDBPK_040260</name>
        <name evidence="7" type="ORF">LdCL_040008100</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858089.1">
        <property type="nucleotide sequence ID" value="XM_003858041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H591"/>
    <dbReference type="SMR" id="A0A3S5H591"/>
    <dbReference type="GeneID" id="13390700"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0330"/>
    <dbReference type="OMA" id="TLMQWPH"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP51447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="480" mass="54090" checksum="F7E466F62727E220" modified="2019-04-10" version="1">MRCSARRANVAALYEFVDGNFLNNKRPAIPGGAWPLESLRRKSLADLQQIWLSLLKERNMLSTIKEHYLRHQEELGAMPAPSRLKMVEESMENVKKVVKERDAEATAEAVRIFKERLAKGIYRYPPGPPPPPGAHDPTSTVKLVLSRRVDEERLRELLGRFDVFEAHKGIVTLTMQLPEDVLTQKRDAEQLWQQYMAERRDVEEYYKWPGSSTGSAESASVYDHTVVELAPGVYSGHRGTSAAESNCVDNSNAGDHGVIQAARLPVPPPKTRPPPPRNPLEHIKYQQRSVLSKAVIQLGYFPNITITAPRFTKADDVPRPVHPDEIEGPWEVRVTYDAKDGLDYVQSLGLTSIDGAAVLSVEEAFPEAAQPYAAVDPVYQEAVRREMAQEETLMKWPNVPKWKYQYDLYTKKHLAQVVQYNYSNVVDYVDREVLLTGRSVWESPIDIDPTCGGMKSVPAHAKKPKRYMTHGLGEVGVTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5E2</accession>
    <name>A0A3S5H5E2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_040015800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5E2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1260"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="222" mass="25869" checksum="C837E74BD5BD0FDC" modified="2019-04-10" version="1">MNDDGPPPAHDAHKRPRRTTSSRGAKSSTNAASSVTSAVAQRRIDPRFDPMFGRADKRMFEQNYGFLREAEEKEEAERRFRIKCLRCVIRRCELEEAGEDLDEYDLSDYEQEVFGEDHQRELREMKLTPPQRLYAELEQLQRASQLYVSKTRDASVKDRRSSVKRELLRKEVVAVKAGRKARPYFPKRAEVKRAMTADTFSRLNDKGGKAAVDRYVIRKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F4</accession>
    <name>A0A3S5H5F4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050005000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0040"/>
    <dbReference type="OrthoDB" id="271872at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="730"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="915" mass="104652" checksum="97C7B466891A9502" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Z7</accession>
    <name>A0A3S5H5Z7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase inhibitor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070013200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Z7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1010"/>
    <dbReference type="OrthoDB" id="265291at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16480" checksum="2D8FA85D5605825F" modified="2019-04-10" version="1">MDALSVRQHQNHVHQADSLVPTRTAVLHLRPAPTAEEAERAQRQHDMRVTWSPDVREPVSQHVSKCCCVFHKKKLFGESSSDSSSSSTDSSDEDADSKDAGTTGPGGDSAGCVGHQGGRGHDCQHAHHHPPRKQRPQCTKEHCYCGTRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J5</accession>
    <accession>E9BAU3</accession>
    <name>A0A3S5H6J5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pretranslocation protein, alpha subunit, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Pretranslocation_protein_alpha_subunit_putative/G eneDB:LmjF.11.1050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_111050</name>
        <name evidence="13" type="ORF">LdCL_110016300</name>
        <name evidence="14" type="ORF">LDHU3_11.1280</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859081.1">
        <property type="nucleotide sequence ID" value="XM_003859033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J5"/>
    <dbReference type="SMR" id="A0A3S5H6J5"/>
    <dbReference type="GeneID" id="13389551"/>
    <dbReference type="KEGG" id="ldo:LDBPK_111050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1280"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000009">
        <property type="entry name" value="Pretranslocation protein, alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU76874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5428207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="486" mass="53967" checksum="23BD27F60272BFBD" modified="2019-04-10" version="1">MTKQANWLMSLKPMLAVLPEIEKPRRMPGIKERIMWTAVALFVFLICCQVPVYGARPGNASDPFYWMRIVLASNKGTLMELGISPIVSASLILELLAGVRILTYDPNNREERAVFEGFQKMMGLVITAVEAVAYVSSGMYGDPSRIGVVMCGLIVLQLMVATMICILLDELLQKGWGIGSGTSLFIATNVCDTIIWKAFSPSTINTGRGAEFEGAIIAFFHLLVSRTDKVRALREAFYRPQLPNLTNIFSTAVVFVVVVFFQGFRVPLMTKSKFNGNDRQPYMIKLFYTSNMPIILQTSVVSNISFFSQILSRRFGNRNFLINLLGRWEERGYNGGGNGQLFPVGGLAYYLVPPATFYDLLADPIHAIFYVVFVLTSCAVFSRLWITISHTAPRDVAKQLASQGRWLVQARESEDDMTRLLEKYIPVAASFGGLCVGALTIFADFLGAIGSGTGILLSVTMINQYYEILQQEGQDLGYGFLKQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6K9</accession>
    <name>A0A3S5H6K9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_120010200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6K9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0670"/>
    <dbReference type="OrthoDB" id="267339at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1035" mass="105423" checksum="08954A866F90B82A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6X7</accession>
    <name>A0A3S5H6X7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_160013300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the auxin efflux carrier (TC 2.A.69.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6X7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0960"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045033">
        <property type="entry name" value="PILS1/3/4/5/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31651">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31651:SF33">
        <property type="entry name" value="PROTEIN PIN-LIKES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="750" mass="82318" checksum="531011009A545409" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP18</accession>
    <accession>E9B8B3</accession>
    <name>A0A3S7WP18_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydrogenase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Hydrogenase_putative/GeneDB:LmjF.05.0230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_050230</name>
        <name evidence="8" type="ORF">LdCL_050007200</name>
        <name evidence="9" type="ORF">LDHU3_05.0270</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858210.1">
        <property type="nucleotide sequence ID" value="XM_003858162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP18"/>
    <dbReference type="GeneID" id="13391049"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0270"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="166"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="633" mass="65812" checksum="844C980F9D80E85E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPA1</accession>
    <name>A0A3S7WPA1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pumilio/PUF RNA binding protein 5, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Pumilio/PUF_RNA_binding_protein_5_putative/GeneDB:LmjF.06.0050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_060005400</name>
        <name evidence="6" type="ORF">LDHU3_06.0080</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPA1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0080"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000820">
        <property type="entry name" value="Pumilio/PUF RNA binding protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF59">
        <property type="entry name" value="RNA BINDING PROTEIN 5, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="388"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5427385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="470" mass="51470" checksum="E175999FC2F33A1C" modified="2019-05-08" version="1">MVLKSNYPDAQPPTAMGAPPKKGPQPYRSPCYNSASANPTAASTLTQPFSLPTSLQSPQMLQAHVPRPTVLIPMAGHETIESSKQSGKIYTHNPYASTCTTPSACLSQSTSMESSSFTSPYITAMAPRTTAMTPPHSSCASTFPVYAASEGSCCEAGALANMLEDQFLSVLGNIPSTAMSSRGRHILLNVLRLQHMDKIQMIYDELLPQFNIIAMDQHGCHVARTLIEYISTPQMEALVPYIDPHVILQMATTTQHTRRVLQAIFEHHKSDALMPIVEVVTSDCQHLSVTQQGCIAIIRIIEYAKPAQKRTLISALVPLLSTLAKNQFGNYVVQCILKNMEGYVSLNDLVASFQGHWVELSCDKYSSNVMEKIVGMLQGSLRQRIVNELIFDVAHLQCLMQNSFGNYVLQAVIGSAVNQYEYGLIYDAVTPLLHTSPYGHRIEAKLKSRCDALYSKSAPAGTTPVDAMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPV0</accession>
    <accession>E9B946</accession>
    <name>A0A3S7WPV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_070520</name>
        <name evidence="2" type="ORF">LdCL_070010200</name>
        <name evidence="3" type="ORF">LDHU3_07.0650</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858492.1">
        <property type="nucleotide sequence ID" value="XM_003858444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPV0"/>
    <dbReference type="GeneID" id="13391800"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0650"/>
    <dbReference type="OMA" id="KRISAHH"/>
    <dbReference type="OrthoDB" id="255919at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="159" mass="18685" checksum="B83B6615BEE59F1C" modified="2019-05-08" version="1">MTAESDRQRFSRYVLEISQIQRNHVADRVEQLAHHESLSWQYFFGCIAFSTGSVLAAFKAWGPRHIFKNSMYYARPLPPAISMGVVLYGITFTCRGMLMRNRICIMIEDYEYELKRVKAHHCEEGVTQLAWLEFVLDQLKQGSEQRFDFQKLRETPAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQM7</accession>
    <name>A0A3S7WQM7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Cyclin_1/GeneDB:LmjF.09.0600</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Peptidase S51 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_8190</name>
        <name evidence="5" type="ORF">LdCL_090011600</name>
        <name evidence="6" type="ORF">LDHU3_09.0790</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQM7"/>
    <dbReference type="SMR" id="A0A3S7WQM7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0790"/>
    <dbReference type="OrthoDB" id="61042at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000093">
        <property type="entry name" value="Cyclin 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5427852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP42873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="335" mass="35832" checksum="6A41D5BE908188A4" modified="2019-05-08" version="1">MGAPHLNSIRACLAGSGHDAFSEPVTIDHLLSLVATPKTGVVSVAYVGTATYDLAESQAEQTSLLLQRGWTVRPIQVADPAVKAVNDGDAHFIQTAADIVLVSGGNTLYAVRRWEETGLARLLKDAAARQVVMAGGSAGAICWFTSGHSDSADPATYLQPSLKRAALKMGLIPQDQISKTEAELADLSTSWSYIRVRGLNILPGMLCPHFDVTQGNGVRREEDFTKMLKRHPTERGIGVDHWALLILKGDGTYESAALPGKTRVTTPGNTSPTSTVPGIFVLDVVDGAVQRRRVPTTGQLSDVLREPAGPVVLDPFERFHAMENPTSSSGSLMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRU4</accession>
    <name>A0A3S7WRU4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_110018800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRU4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1600"/>
    <dbReference type="OrthoDB" id="264736at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="186" mass="21020" checksum="CFA71831DE3BA4AD" modified="2019-05-08" version="1">MNSVSCAPLTEAEVRELSTAEIRLNLERCSRLLSQASLLRRLRDGGEGIRRRSQLFAKELKRRHRVEAANGDASTRLTPSTLTEALKRDNEAAILSESTHNATDAAREIAQKYKDHRVDVEATVRRMYEGILSESEIQRILQSVPPRFFLTYAETCEMERQLARDARKAELQKLAAQAARLSATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSH2</accession>
    <accession>E9BBD5</accession>
    <name>A0A3S7WSH2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like_protein/GeneDB:LmjF.13.0720</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Zinc-binding dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_17275</name>
        <name evidence="5" type="ORF">CGC21_33245</name>
        <name evidence="4" type="ORF">LDBPK_130610</name>
        <name evidence="2" type="ORF">LdCL_130011500</name>
        <name evidence="3" type="ORF">LDHU3_13.0800</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859272.1">
        <property type="nucleotide sequence ID" value="XM_003859224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSH2"/>
    <dbReference type="SMR" id="A0A3S7WSH2"/>
    <dbReference type="GeneID" id="13390462"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0800"/>
    <dbReference type="OMA" id="NFADTHQ"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="342" mass="36794" checksum="2EA4A7AA90196EDD" modified="2019-05-08" version="1">MAAAARTYRHIVARELSTNFRAVASIVEAPFPTELHPKAILVKNKYLGINASDINFTAGIYQPNVRPPFACGFEAVGEVVDVGSGVKDLKAGAAVVTQSYGAFTEYQVVARRHAKPIPRMAREYLPLDLSATTASIALEHVLKPQPGERAVVTAAAGGTGQFAVQLLKHVYGCSVVGTCSSPSKEVFLTNTLKCDGVVNYKAEGGDTAAAFLRCYPRGVSIAYESVGGDLLEAVIQSLAPRGRILSLGCVSTYQRGSIEAACPNRKPLPLQLLAKSASLSTFFLPHFAKYGQLHFDRLCALHEQGILHCCIDPATFRGLEGVYDAIDWMFEQKNCGKVMVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSN2</accession>
    <name>A0A3S7WSN2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_130014700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1150"/>
    <dbReference type="OrthoDB" id="1740355at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019461582" evidence="8">
        <location>
            <begin position="29"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1706"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="129"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="840"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1536"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="848"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1301"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1555"/>
            <end position="1564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1741" mass="184366" checksum="34B90E7D68969974" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT18</accession>
    <name>A0A3S7WT18_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin, putative</fullName>
            <ecNumber evidence="7">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_140014200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1110"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="198"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="853"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1308" mass="140870" checksum="B5C9E00F879CFF90" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTU9</accession>
    <name>A0A3S7WTU9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160010100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTU9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0620"/>
    <dbReference type="OrthoDB" id="273828at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1193" mass="128387" checksum="FA71681FA57B9EDC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUP9</accession>
    <name>A0A3S7WUP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetoplast polyadenylation/uridylation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_180005000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUP9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0010"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002028">
        <property type="entry name" value="Kinetoplast polyadenylation/uridylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001190">
        <property type="entry name" value="Kinetoplast_polyadenylation/uridylation_factor_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002556">
        <property type="entry name" value="Kinetoplast_polyadenylation/uridylation_factor_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF86">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="738"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="920"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1002" mass="113741" checksum="6EB626978A282E8E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUZ1</accession>
    <name>A0A3S7WUZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_180013300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1070"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001081">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001228">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000550">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="1639"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2112"/>
            <end position="2139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2661" mass="289883" checksum="597572239A0A94EF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV31</accession>
    <accession>E9BDP4</accession>
    <name>A0A3S7WV31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_3230</name>
        <name evidence="3" type="ORF">LDBPK_180640</name>
        <name evidence="2" type="ORF">LdCL_180011500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860077.1">
        <property type="nucleotide sequence ID" value="XM_003860029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV31"/>
    <dbReference type="GeneID" id="13393501"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0840"/>
    <dbReference type="OMA" id="PWHPLFT"/>
    <dbReference type="OrthoDB" id="267414at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="562" mass="61541" checksum="C68336AE7273D473" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVD2</accession>
    <accession>E9BE26</accession>
    <name>A0A3S7WVD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_19435</name>
        <name evidence="8" type="ORF">CGC21_19440</name>
        <name evidence="6" type="ORF">LDBPK_190300</name>
        <name evidence="5" type="ORF">LdCL_190008000</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860209.1">
        <property type="nucleotide sequence ID" value="XM_003860161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVD2"/>
    <dbReference type="GeneID" id="13386021"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0350"/>
    <dbReference type="OMA" id="HIKGKCR"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19851">
        <property type="entry name" value="OS02G0203500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP51036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="392" mass="42520" checksum="84872C2C23C434F0" modified="2019-05-08" version="1">MNAMSPFYGRTYPTRTTPLMWEATQTLQSSLVDQSSDMRRSLDLAMSLHEVLERNREIYNNIIAERNEAYRRLQDADAKLQQVEHVVRRYAEVKDPVVASDGYTYERTELSRYLSDCKKSNSKAYSQQTKEELTDVMVDNVSLRRLAELLKGVHSVEVPQLSSRPLLAGGVVDVNGPRSHWAEEDPSMSGADHTEMGHGPVGLAGGAGGRGGNGMAVGLGHAGLRYDRSGGAKYGKPSNGNEGKGGLHPCLRVYGFCNFEDDCTFANYPYEACLNHIKGKCRFGSTCKELHVDPRDPVYQNTRSFANHHHQGGNSANTNHAHNNAAACANNANSSQAADVGAEASRQSGSKMPDSVAEREAEIAAAKKDGKSKETEEPASAAGADAAKAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVG1</accession>
    <name>A0A3S7WVG1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase A-like protein</fullName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_190015200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVG1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1230"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000021">
        <property type="entry name" value="tRNA pseudouridine synthase A-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000050">
        <property type="entry name" value="tRNA pseudouridine synthase A-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="412"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="525" mass="58290" checksum="035FCD24394FCAFB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVQ4</accession>
    <name>A0A3S7WVQ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeats (3 copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_190016300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1360"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000669">
        <property type="entry name" value="SPRY domain/Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2382"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="3784"/>
            <end position="3816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1699"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2119"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2864"/>
            <end position="2884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3078"/>
            <end position="3102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3462"/>
            <end position="3487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3673"/>
            <end position="3693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3814"/>
            <end position="3850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4007"/>
            <end position="4046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4078"/>
            <end position="4115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4499"/>
            <end position="4532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4569"/>
            <end position="4601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4733"/>
            <end position="4760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4775"/>
            <end position="4800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5090"/>
            <end position="5109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5220"/>
            <end position="5244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5329"/>
            <end position="5381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5399"/>
            <end position="5459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5621"/>
            <end position="5677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3092"/>
            <end position="3102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="3475"/>
            <end position="3485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3814"/>
            <end position="3834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4027"/>
            <end position="4036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4087"/>
            <end position="4104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4499"/>
            <end position="4509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4579"/>
            <end position="4593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="4776"/>
            <end position="4792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5233"/>
            <end position="5244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5359"/>
            <end position="5371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5406"/>
            <end position="5419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5445"/>
            <end position="5457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5641"/>
            <end position="5650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="5761" mass="610399" checksum="C370A67AAACC3DA4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX59</accession>
    <name>A0A3S7WX59_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinesin, putative</fullName>
            <ecNumber evidence="5">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_220015200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="5"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX59"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1270"/>
    <dbReference type="OrthoDB" id="272935at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="338"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="490"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="815"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="960"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1255" mass="139788" checksum="A05130BB3CEE2D02" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYR7</accession>
    <accession>E9BHD3</accession>
    <name>A0A3S7WYR7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RNA-binding_protein_putative/GeneDB:LmjF.25.0290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_250290</name>
        <name evidence="2" type="ORF">LdCL_250008000</name>
        <name evidence="3" type="ORF">LDHU3_25.0360</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861360.1">
        <property type="nucleotide sequence ID" value="XM_003861312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYR7"/>
    <dbReference type="SMR" id="A0A3S7WYR7"/>
    <dbReference type="GeneID" id="13391529"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0360"/>
    <dbReference type="OMA" id="RDEYFWP"/>
    <dbReference type="OrthoDB" id="273327at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="584" mass="62120" checksum="71EBB7811784AC71" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZH9</accession>
    <name>A0A3S7WZH9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_260007100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZH9"/>
    <dbReference type="SMR" id="A0A3S7WZH9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0240"/>
    <dbReference type="OrthoDB" id="276123at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="252" mass="28904" checksum="44CC141FBD4786FF" modified="2019-05-08" version="1">MTTHSVYGNASDMPAVPAPESAIKRAAFKQQQTENFKKTVVARKAAKAALKKTAYLRARKYSREYRGAEKKLVTLRRQAASHGNYYLEAKPKVAVVTRIRGIAKVNPKQRKILQLLRLRQIFNTVFVKMNKPMENMLRAVEPYIAYGYPSLATVRAMVYKRGYLKINGQRVKITDNQMIKDKYNNADIVCAEDMVNQIYTCGKHFRTVTHGMWPFKLAPPAGGMRQKRRHFVEGGDYGNRDTLINRFLARMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZY4</accession>
    <accession>E9BII3</accession>
    <name>A0A3S7WZY4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein_kinase_putative/GeneDB:LmjF.26.1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_5315</name>
        <name evidence="12" type="ORF">LDBPK_261710</name>
        <name evidence="10" type="ORF">LdCL_260022700</name>
        <name evidence="11" type="ORF">LDHU3_26.2140</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP52046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861757.1">
        <property type="nucleotide sequence ID" value="XM_003861709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZY4"/>
    <dbReference type="GeneID" id="13389004"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2140"/>
    <dbReference type="OMA" id="ARAIINC"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001166">
        <property type="entry name" value="Protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000840">
        <property type="entry name" value="Protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="743"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5431008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP52046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113678" checksum="356AB991CBAA07B3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZZ0</accession>
    <name>A0A3S7WZZ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_260017500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZZ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1480"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="175"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="566" mass="61400" checksum="83812C34D5336B8F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0S6</accession>
    <name>A0A3S7X0S6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BRO1-like domain/ALIX V-shaped domain binding to HIV, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_270022400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0S6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2370"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09034">
        <property type="entry name" value="BRO1_Alix_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="648"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="753"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="915" mass="102517" checksum="FFBCDF2EFF6F25A9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1J7</accession>
    <name>A0A3S7X1J7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_280020100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1J7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1980"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000004">
        <property type="entry name" value="DNA polymerase kappa, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000054">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000025">
        <property type="entry name" value="Putative DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="145"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="511"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="598" mass="67066" checksum="C754503C17A44F26" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X460</accession>
    <name>A0A3S7X460_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_310010200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0700"/>
    <dbReference type="OrthoDB" id="268518at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="246"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="777" mass="88008" checksum="66854ACBD3C21802" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5S5</accession>
    <accession>E9BNZ1</accession>
    <name>A0A3S7X5S5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_322400</name>
        <name evidence="1" type="ORF">LdCL_320029300</name>
        <name evidence="2" type="ORF">LDHU3_32.2980</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863653.1">
        <property type="nucleotide sequence ID" value="XM_003863605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5S5"/>
    <dbReference type="GeneID" id="13390941"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320029300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2980"/>
    <dbReference type="OMA" id="QCEKRLF"/>
    <dbReference type="OrthoDB" id="261029at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="347" mass="37783" checksum="3F5E2CF4DA97B805" modified="2019-05-08" version="1">MMSGESENASCTTHITLPHELDTVPQMISTSEISEGTSSSNASAVSAGSTAIPECASTRGNTPDATATAAALPPFSWALSLHPYGANVPLLYKLSAEDAALRADIAVNAKLLLHTLTGYEADDIIDLLYVNETWFSTEVLIYALCLVNRLTSRYPSWRAEHAEADRVDASAVDSPVRCSYTSGVQTLSPTLTHVCSSTSSDTSHVDNEDDITMNDRVSEPKERIRSSSTNNFSDVFNRHNTRRRVVALLLIAGKFHGDVVYKTSSLANALNKFRDEKRSLQEQCAAAAPTAPTATTPAKLMPSRPPPRIAPAHLGQCEKRLFQELGCTVFVHRKEYQHCEDIVFRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6D9</accession>
    <name>A0A3S7X6D9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRE1 E3 ubiquitin ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330011800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6D9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0910"/>
    <dbReference type="OrthoDB" id="188741at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037386">
        <property type="entry name" value="CCDC40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16275">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16275:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="767"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="875" mass="101427" checksum="CF173D4AAC064E0B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6H4</accession>
    <name>A0A3S7X6H4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330015000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6H4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1420"/>
    <dbReference type="OrthoDB" id="273665at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="916" mass="99557" checksum="939591930767DC31" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7J0</accession>
    <accession>E9BQL1</accession>
    <name>A0A3S7X7J0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1 2">Leucine-rich repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_25635</name>
        <name evidence="2" type="ORF">LDBPK_340570</name>
        <name evidence="1" type="ORF">LdCL_340011300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864222.1">
        <property type="nucleotide sequence ID" value="XM_003864174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7J0"/>
    <dbReference type="GeneID" id="13392631"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0960"/>
    <dbReference type="OMA" id="RLAINSC"/>
    <dbReference type="OrthoDB" id="271218at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF105">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP39973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="621" mass="65802" checksum="DF8B02C8B0863793" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7P6</accession>
    <name>A0A3S7X7P6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340020300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7P6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2200"/>
    <dbReference type="OrthoDB" id="266575at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="784" mass="82391" checksum="6EBB7000A98E5F29" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAZ9</accession>
    <name>A0A3S7XAZ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Topoisomerase 6 subunit A/Spo11 TOPRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_13750</name>
        <name evidence="2" type="ORF">LdCL_360035600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAZ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360035600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4070"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000030">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="1">
        <location>
            <begin position="247"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="493" mass="53561" checksum="23D97E8B6E3F4B62" modified="2019-05-08" version="1">MSTTATSHDCHRAPYHQQLQSHIEALLLLFLRDFCAEGASPTRNGYRASHLQAIAQTFYVLQIVRCSTAPRREQETPYSLLQTGDGTSRLDVCTERDLYYRNPPLFAPRGQRATHESIKRLCGWLEVVARVPPHQQRGEGPVLTSLFRSPRCLLSRPWKGAQGAASLTPLYTRESLGITAAGKSLLAGAITLELCDPVELIDVSARGSAGITLTYSLATRMVGCREAGVWQAARDGISSSRPYRLVLIEKESVHHAVLQSMTKSGTPHTYSCILLCTKGYPCVAAREWLRRVHALRPALQLYIMVDGDPDGLGIALTVMGLLGSKGYPSPIASSQPKPTLSSFSPLSGATPASAETAKVKELLPLRFLGVCPSLVWSCNFQSEAPLSAGFLGGLASSQGIPLTMHDVQVLKRVVSIVQGALASAPEASDSATSLRGCDTAIVRHTLQRVLKEAEWMQRARIKCELQFACGPIGPLTFMEQHVQRCDAELSEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBU7</accession>
    <accession>E9BUP7</accession>
    <name>A0A3S7XBU7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MIF4G domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC22, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing_factor_CWC22_putative/GeneDB:Lm jF.36.5160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_19585</name>
        <name evidence="10" type="ORF">LDBPK_365390</name>
        <name evidence="8" type="ORF">LdCL_360061100</name>
        <name evidence="9" type="ORF">LDHU3_36.7210</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865653.1">
        <property type="nucleotide sequence ID" value="XM_003865605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBU7"/>
    <dbReference type="GeneID" id="13388539"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360061100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7210"/>
    <dbReference type="OMA" id="VIEGCCE"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000096">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC22, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="358"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5435118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP49640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="565" mass="65273" checksum="3E82146B7DB8E637" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC57</accession>
    <accession>E9BV06</accession>
    <name>A0A3S7XC57_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_19040</name>
        <name evidence="17" type="ORF">CGC21_15495</name>
        <name evidence="16" type="ORF">LDBPK_366490</name>
        <name evidence="14" type="ORF">LdCL_360072400</name>
        <name evidence="15" type="ORF">LDHU3_36.8600</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865761.1">
        <property type="nucleotide sequence ID" value="XM_003865713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC57"/>
    <dbReference type="SMR" id="A0A3S7XC57"/>
    <dbReference type="GeneID" id="13386615"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360072400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8600"/>
    <dbReference type="OMA" id="GMNWICS"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04155">
        <property type="entry name" value="Arl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000281">
        <property type="entry name" value="ADP-ribosylation factor-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5435229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP48749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP49531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="178" mass="20063" checksum="E4A3F05C781EBEC4" modified="2019-05-08" version="1">MGILDFLMRIRPTSRPAGILILGLDNAGKTSILRQLSDEDISHVASTQGFQIKKLVTGGIKINVWDMGGQRAARYYWRQYFKEADVVIYVIDAADPRRIREARRELEHLLEEEKVAGVPMLVFANKQDLLGAMSVEEVSVALNLTDLRDRRWHIQACSAKTGEGLDEGISWAVKQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJQ8</accession>
    <accession>E9B7S3</accession>
    <name>A0A451EJQ8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable quinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_30230</name>
        <name evidence="7" type="ORF">LDBPK_030550</name>
        <name evidence="5" type="ORF">LdCL_030010600</name>
        <name evidence="6" type="ORF">LDHU3_03.0580</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="8">
        <citation type="journal article" date="2024" name="Biochem. Biophys. Res. Commun." volume="690" first="149096" last="149096">
            <title>Distinct oligomerization and NADPH binding modes observed between L. donovani and human quinone oxidoreductases.</title>
            <authorList>
                <person name="Vishwakarma C."/>
                <person name="Ansari A."/>
                <person name="Pratap J.V."/>
            </authorList>
            <dbReference type="PubMed" id="37988924"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2023.10.028"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000043">
        <property type="protein sequence ID" value="TPP45068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858020.1">
        <property type="nucleotide sequence ID" value="XM_003857972.1"/>
    </dbReference>
    <dbReference type="PDB" id="8J6E">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A=1-332"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJQ8"/>
    <dbReference type="SMR" id="A0A451EJQ8"/>
    <dbReference type="GeneID" id="13390395"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0580"/>
    <dbReference type="OMA" id="KGMTAHY"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU75732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5427087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8J6E"/>
        </source>
    </evidence>
    <sequence length="332" mass="34503" checksum="EDD05110E22AAD9D" modified="2019-05-08" version="1">MEVIATAHGGPEVLTVRPSSHTPDATQLEGGQVLVRNAYAGVNFIDTYFLSGLYKKPAMPYVVGEEGAGAVVKVGAGVPETMLGKRVAYFGGAGCTGSYAAFTVAPASALREVPDEVTDAEAAAVMCQGLTAHYLVDSSYPCGPGSTVAVHAAAGGTGLLVCQMAKLRGARVIGLCGGAEKATLARSVGRADVVIDYVATPDWAPLVRAAAPQGVDAVYDGVGQATFAGSLSVLRPRGYMITFGNASGAVPPVSPMELSRAGSVYLQRPTLGDFMRTPEEVQRRTSEVFGWVASKQVQLTIGHEYPLHEAAQALTDLQSRKTTGKLLLKCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJS4</accession>
    <name>A0A451EJS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TatD related DNase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030012500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJS4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0820"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF47">
        <property type="entry name" value="TATD RELATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="716" mass="75928" checksum="32AC7D4203AD9200" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9Z0</accession>
    <accession>A0A3S7WQR9</accession>
    <name>E9B9Z0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_091040</name>
        <name evidence="2" type="ORF">LdCL_090015900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858783.1">
        <property type="nucleotide sequence ID" value="XM_003858735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9Z0"/>
    <dbReference type="GeneID" id="13392118"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1210"/>
    <dbReference type="OMA" id="YEMFARW"/>
    <dbReference type="OrthoDB" id="267967at2759"/>
    <dbReference type="PhylomeDB" id="E9B9Z0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="997" mass="103091" checksum="67E4313AA4335B46" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BA02</accession>
    <accession>A0A3S7WQV1</accession>
    <name>E9BA02_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_091170</name>
        <name evidence="2" type="ORF">LdCL_090018100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858795.1">
        <property type="nucleotide sequence ID" value="XM_003858747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BA02"/>
    <dbReference type="GeneID" id="13392129"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1400"/>
    <dbReference type="OMA" id="CLPLDAW"/>
    <dbReference type="OrthoDB" id="266535at2759"/>
    <dbReference type="PhylomeDB" id="E9BA02"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="458" mass="51323" checksum="7000566367DAEB23" modified="2011-04-05" version="1">MFLFRHSAEPMEEEEEHHEPVDSTMEPHNADTAAAEERRTSADVADGDISREPSGFAESFEETGGAPHTPREGTVPPPHVHDMLQHQHLHDEDDVEADMAAAAPAASAPAPSHGVPALPMPHTCNEDSQAEADGNGAQRHRSYSHTSRFAAPSPRSTSGISRGRSYSLSGLSAAELADVHEQRYRRCTSVVKSARCISARRASSVNGVVGVIDDLYTLASRRSSVMTEGERVAVERMMENEYRRQEAAERSAQLALARESTIVNEELAREKAMYVRRMRLNEDLHARLAKSSRIRQERMTAAAQRRQEIEQERLRVLYDSMMEKDTRYHFRNPYEMMAAQRRYSIEMRNPAAIAPQRRTSSPSTRANGNAQMSPHSSDGVANGTTEDRCTSSPATRRRSSTPSIAKSKPRQCLPLDAWKKPEPPRKDSCRSDISAEHRCRSPNDWRATAVLEHPRQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAF6</accession>
    <accession>A0A3S7WRA0</accession>
    <name>E9BAF6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_101120</name>
        <name evidence="3" type="ORF">LdCL_100018100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858946.1">
        <property type="nucleotide sequence ID" value="XM_003858898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAF6"/>
    <dbReference type="GeneID" id="13389245"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1470"/>
    <dbReference type="OMA" id="WLRWCLQ"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="PhylomeDB" id="E9BAF6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051493">
        <property type="term" value="P:regulation of cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF8">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CH-like" evidence="2">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1223" mass="126473" checksum="3DF20E01138ED32A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAG4</accession>
    <accession>A0A3S5H6H2</accession>
    <name>E9BAG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAB1-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_101200</name>
        <name evidence="3" type="ORF">LdCL_100019000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858954.1">
        <property type="nucleotide sequence ID" value="XM_003858906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAG4"/>
    <dbReference type="GeneID" id="13389315"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1560"/>
    <dbReference type="OMA" id="CPTDWPG"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="PhylomeDB" id="E9BAG4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="523" mass="56323" checksum="5956DC74EC11D191" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD63</accession>
    <accession>A0A3Q8IAP9</accession>
    <name>E9BD63_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_170420</name>
        <name evidence="3" type="ORF">LdCL_170009700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859896.1">
        <property type="nucleotide sequence ID" value="XM_003859848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD63"/>
    <dbReference type="GeneID" id="13393342"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0700"/>
    <dbReference type="OMA" id="AFIHAYW"/>
    <dbReference type="OrthoDB" id="267303at2759"/>
    <dbReference type="PhylomeDB" id="E9BD63"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="84707" checksum="6782029858D9FDA1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIB8</accession>
    <accession>A0A3Q8IFT6</accession>
    <name>E9BIB8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_261060</name>
        <name evidence="2" type="ORF">LdCL_260016200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861693.1">
        <property type="nucleotide sequence ID" value="XM_003861645.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13388939"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1340"/>
    <dbReference type="OMA" id="YPLDMRN"/>
    <dbReference type="OrthoDB" id="266786at2759"/>
    <dbReference type="PhylomeDB" id="E9BIB8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1925" mass="202725" checksum="90E7E33E47F077C0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIT0</accession>
    <accession>A0A3Q8IE13</accession>
    <name>E9BIT0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_262690</name>
        <name evidence="3" type="ORF">LdCL_260032900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861853.1">
        <property type="nucleotide sequence ID" value="XM_003861805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIT0"/>
    <dbReference type="GeneID" id="13389101"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3510"/>
    <dbReference type="OMA" id="AIAECKS"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="PhylomeDB" id="E9BIT0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000117">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="92894" checksum="783D64AFBE55BA68" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKI5</accession>
    <accession>A0A3Q8IF75</accession>
    <name>E9BKI5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_290390</name>
        <name evidence="4" type="ORF">LdCL_290008700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862456.1">
        <property type="nucleotide sequence ID" value="XM_003862408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKI5"/>
    <dbReference type="GeneID" id="13387195"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0530"/>
    <dbReference type="OMA" id="LNCVRDT"/>
    <dbReference type="OrthoDB" id="265147at2759"/>
    <dbReference type="PhylomeDB" id="E9BKI5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005638">
        <property type="term" value="C:lamin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000290">
        <property type="entry name" value="Domain_of_uncharacterized_function_(DUF3451)_-_pu tative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052877">
        <property type="entry name" value="Lamin_tail_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19956">
        <property type="entry name" value="LAMIN TAIL DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19956:SF5">
        <property type="entry name" value="LAMIN TAIL DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="820"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="975" mass="104740" checksum="433A5448686FA7AE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLA2</accession>
    <accession>A0A3Q8IEJ7</accession>
    <name>E9BLA2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_300070</name>
        <name evidence="1" type="ORF">LdCL_300005700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862723.1">
        <property type="nucleotide sequence ID" value="XM_003862675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLA2"/>
    <dbReference type="GeneID" id="13385429"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0120"/>
    <dbReference type="OMA" id="VRYRCHI"/>
    <dbReference type="OrthoDB" id="276174at2759"/>
    <dbReference type="PhylomeDB" id="E9BLA2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20719" checksum="6A1AA907F8FDECFF" modified="2011-04-05" version="1">MGGQDSMNPNAQITTRDAAGNMARARYRCHIESSGGMKLEMLVRVQMGWISPRVVFSQIPYVIHLGKGIDVSIPFVLHFTMVSLLDEHGDNTGSFLYFSGTPMLGFSSGFSRIKGGKMVLNPTKVVDPYVEVFDFIGHVHYRQMGFVLFKCLGYLLCFLACIPATQRMLQCVLPDPFHRHSEKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BN72</accession>
    <accession>A0A3Q8IGF1</accession>
    <name>E9BN72_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_313020</name>
        <name evidence="2" type="ORF">LdCL_310038500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863387.1">
        <property type="nucleotide sequence ID" value="XM_003863339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BN72"/>
    <dbReference type="GeneID" id="13389958"/>
    <dbReference type="KEGG" id="ldo:LDBPK_313020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310038500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5190"/>
    <dbReference type="OMA" id="QHMAQFL"/>
    <dbReference type="OrthoDB" id="264790at2759"/>
    <dbReference type="PhylomeDB" id="E9BN72"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="247" mass="27136" checksum="283290B40679712F" modified="2011-04-05" version="1">MPPASNTPAREKEHLHRMFSAAANALADLYRESSNSYEAGYRDALLFVQRYLQSSSPVTERGLPPSSAFSICETVNAQHMAQFLQHTIATRRERMAAVRGIHSLRRRRRESEQGNSGIDDAGIARDDGDARENDEDDDGEEPCLTPRSSPVVAIEPPADLTALAASGVVSTATPRFSPGALVTVNSTSPALSREMEHVIHTEHPVSGRLPYQPRRQRPRMERMHGHGSLGSADGRPLPTQLRIGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ43</accession>
    <accession>A0A3S7X6P8</accession>
    <name>E9BQ43_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YEATS family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_331140</name>
        <name evidence="6" type="ORF">LdCL_330017500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863938.1">
        <property type="nucleotide sequence ID" value="XM_003863890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ43"/>
    <dbReference type="GeneID" id="13392335"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1750"/>
    <dbReference type="OMA" id="DDTWAEH"/>
    <dbReference type="OrthoDB" id="10053467at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ43"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000010">
        <property type="entry name" value="YEATS family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="8"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="445" mass="48344" checksum="C771A080853CF69A" modified="2011-04-05" version="1">MSAESQRVVYGATFDIPYAIGSVSVPLEALGAPSPSRVGVQDARGAGPSPSPSRRRGVSSGNISSVRRCTHHRYCYVRDGSELLQDAFYRWLEQQRQEHREGTHASSTGGPPHEASGGPLTPATDSASSTNAPSSAPPDAPSSPSLFYASVKCVVFVLPNSFPRPRRVLRRPPFIIEDDTWAEHVVEVQLHFWPHLKIPPATVVHQALLERRVLTAPPPYQSGAVSPAAPTEDLREVWVPQLLASTYGKPKLLSVATNVAVPAPARRATAPAPGTAKAASRVVVVAEKVDTLHLYHPSLDVIRHIRAVLAMSRMPILEAVRDAFDATYSAQPSTNADGNSHGARSPTPTDAAATSRAAEDSSLLTPFAHSWSLPFEDIIAEYAEQRASTSVAVLQAVLEKLKRERQEMEKSCERSMEEIAELATVVLPTQLERVHMRCMKLHKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR58</accession>
    <accession>A0A3S5H7X2</accession>
    <name>E9BR58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_342600</name>
        <name evidence="2" type="ORF">LdCL_340033600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864419.1">
        <property type="nucleotide sequence ID" value="XM_003864371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR58"/>
    <dbReference type="GeneID" id="13392828"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340033600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4220"/>
    <dbReference type="OMA" id="SSKALWY"/>
    <dbReference type="OrthoDB" id="265468at2759"/>
    <dbReference type="PhylomeDB" id="E9BR58"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="343" mass="36246" checksum="A51255259CB68F1F" modified="2011-04-05" version="1">MVKQSAAQVPLRVPSTRVRNESHSINADGKQTCCPSLKVIGAAARKPSAALADAPLRRKRVPAVPTTPKRAGGWNAPWQPRRGSSGITPDEDSRKAREHLRHSPPGKRRGNSIGHRSHSAGASRHAQRPASDMVTVGLPRMHSSPQAVTSVHENGLTSDDLLLLCGVKPGSSKALWYTTMRAQLEARALATAAEQSDRGDSATSNRPRTGVGSSSSSSHSLTRRADASSEPLVLPTALLLLTEPSDLNAHTMGAPESAAQQKGKIPRTRSGEDDAEKVEEDDGASSLGTRSTSLCSEKVANASVTQGAPNAVPLVPLKKLRLSPKQLTQMRVSVLSLQALADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8M5</accession>
    <name>A0A3Q8I8M5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_090019000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1500"/>
    <dbReference type="OrthoDB" id="262489at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1428"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1544" mass="165853" checksum="44101044085CC4F9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I942</accession>
    <name>A0A3Q8I942_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_150011300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0770"/>
    <dbReference type="OrthoDB" id="267708at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1670"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1768" mass="190835" checksum="7890DC1894FEBF0A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9S7</accession>
    <name>A0A3Q8I9S7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_170016200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1450"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002950">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001159">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001359">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000313">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003667">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="493"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="713"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1879"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2368" mass="260057" checksum="9D66C59601DFAEFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA46</accession>
    <name>A0A3Q8IA46_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150010800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0720"/>
    <dbReference type="OrthoDB" id="266570at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1623"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1751" mass="183877" checksum="04999F31EFE3B013" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA94</accession>
    <name>A0A3Q8IA94_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210010000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA94"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0560"/>
    <dbReference type="OrthoDB" id="264021at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="912" mass="98737" checksum="5D99E9A8465DA5AB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAA6</accession>
    <name>A0A3Q8IAA6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_11040</name>
        <name evidence="11" type="ORF">CGC20_30365</name>
        <name evidence="10" type="ORF">CGC21_1450</name>
        <name evidence="12" type="ORF">CGC21_38210</name>
        <name evidence="6" type="ORF">LdCL_150016100</name>
        <name evidence="7" type="ORF">LdCL_330013200</name>
        <name evidence="8" type="ORF">LDHU3_15.1350</name>
        <name evidence="9" type="ORF">LDHU3_33.1080</name>
    </gene>
    <organism evidence="6 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000037">
        <property type="protein sequence ID" value="TPP53177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAA6"/>
    <dbReference type="SMR" id="A0A3Q8IAA6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1080"/>
    <dbReference type="OrthoDB" id="276589at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000046">
        <property type="entry name" value="Putative 60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5433262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP47708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP53791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP55614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="195" mass="21164" checksum="4ED284A3ADE515DE" modified="2019-04-10" version="1">MAATKSAASAAKRKAAKKVSRKSPEYTTLRKSCAPGVIAIILAGRFRGRRAVILKQLPHNGPLVVSGPMKYNGVPIRRIDSRYVIATSTKVDISSVDTAPITPEVFQRPKAEKLTKSEGDFMGDKQKARAEKAAKKTSKAGKKTPVSDARAQLQKKIDAALIAAIKKDAQGKEKAGYLRSVFTVKPGDAPHRWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAU1</accession>
    <name>A0A3Q8IAU1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ion transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_170022100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.2140"/>
    <dbReference type="OrthoDB" id="272031at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000149">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1017"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1099"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1185"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="327"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="649"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="987"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU77923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1432" mass="156748" checksum="95EE1E22A71CCFE0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAY6</accession>
    <accession>E9BEW6</accession>
    <name>A0A3Q8IAY6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA (Uracil-5-)-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_29035</name>
        <name evidence="7" type="ORF">LDBPK_201680</name>
        <name evidence="6" type="ORF">LdCL_200021600</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860508.1">
        <property type="nucleotide sequence ID" value="XM_003860460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAY6"/>
    <dbReference type="GeneID" id="13386292"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.2050"/>
    <dbReference type="OMA" id="HGQPHIY"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP49841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="603" mass="65234" checksum="294ECDF287639C32" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB91</accession>
    <name>A0A3Q8IB91_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_240010100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB91"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0640"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000194">
        <property type="entry name" value="Putative DNAJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018628315" evidence="2">
        <location>
            <begin position="33"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="794" mass="88827" checksum="B3DB0C25E40A2778" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBD3</accession>
    <name>A0A3Q8IBD3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA box-binding protein-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-like factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_190020000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBD3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1730"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04517">
        <property type="entry name" value="TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000022">
        <property type="entry name" value="Transcription initiation factor-like protein (TFIID-like protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000024">
        <property type="entry name" value="Transcription initiation factor-like protein (TFIID-like protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015445">
        <property type="entry name" value="TBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="293" mass="31255" checksum="7ACE290725801C85" modified="2019-04-10" version="1">MDDDYAFFESDNLVEEELPVIGAFPDTVAEFGGVVGPTGAIGDSALTADGHLAAAAATLPGGDDAAANLDVDELPPPIKNVQEFLPNVHPDAFPVVVAVQAQASIPVGINLAELSCATRNVEYMPNNRIPSATMRLHEPTAVVMMHNSGALSIIGAASVSEARQAAELAARIIRKALNLNFSSLKFRVRSIAARFNVCSPIRLDKLAAYQLDPAMSIGVAKLQVSYEPERFNGCVLRLVGKSSRGDNQWSVSCSVFVTGKVQLMGARSMDELRFAFNAFVPIIAKNLDERKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBS3</accession>
    <name>A0A3Q8IBS3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine peptidase, Clan CA, family C2, putative</fullName>
            <ecNumber evidence="5">3.4.22.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200016600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.33" evidence="5"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBS3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1510"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="410"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="910" mass="101334" checksum="0693A81D42BC40C7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICA1</accession>
    <name>A0A3Q8ICA1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_150014000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICA1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1100"/>
    <dbReference type="OrthoDB" id="264787at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="563" mass="60714" checksum="F7FE86569215906E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICB7</accession>
    <name>A0A3Q8ICB7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_310005800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICB7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0120"/>
    <dbReference type="OrthoDB" id="298589at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="492" mass="55892" checksum="07DCD2A22F9A59B7" modified="2019-04-10" version="1">MSRAHRDHTWMKNHPLEGDDIVAGLYNILAKRNPKTMKACRGIRIPDTVVFEHNFPRGWYTTDMKAKEVVRKQGKDLDANTIEHGFTQDLCDGSPIAATYLCTTEQTTDDGETEVNTLVEVFTRDTLAAFLARKVKPDGILQKFILPKGYQNSVIKVVWSPRVCMVQRRTNKYRIFDRKRAERDPFSITVTYDGPTFLSDEGSVSGNIAIEVKQLCGNIVQHFYYTEHKYITRMVLYFKGDQRDRLWLLWCGSLRVSDRNTPSEMPVNLITNFGEPSMADNAFDEEELLRSADEAYLRLTTDEMFYETYMKRMGCRGAAYSEAAAQGDKPSSSSADGQQEGRASSGAAADAFDWSGLPSLAVETRDRILLEKKSMCCLFEDLFYHARNHFLTRRAEPYNMEIPTDAADALTENGVVDLMRTLRLPAKVQESTASAHMCYVIDSVSRQPLTQLADKAQVWIQTYFDTKLRRLQQAVLAFAGDEDALRSDVMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICG8</accession>
    <accession>E9BG04</accession>
    <name>A0A3Q8ICG8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_16100</name>
        <name evidence="17" type="ORF">CGC21_2010</name>
        <name evidence="16" type="ORF">LDBPK_221390</name>
        <name evidence="14" type="ORF">LdCL_220021100</name>
        <name evidence="15" type="ORF">LDHU3_22.1990</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860885.1">
        <property type="nucleotide sequence ID" value="XM_003860837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICG8"/>
    <dbReference type="SMR" id="A0A3Q8ICG8"/>
    <dbReference type="GeneID" id="13389608"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1990"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000015">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="13">
        <location>
            <begin position="6"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU78854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5430117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP54008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="962" mass="105980" checksum="53EBD2A422DE5B4A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID94</accession>
    <accession>E9BIX2</accession>
    <name>A0A3Q8ID94_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_33190</name>
        <name evidence="5" type="ORF">CGC21_31280</name>
        <name evidence="3" type="ORF">LDBPK_270380</name>
        <name evidence="1" type="ORF">LdCL_270008600</name>
        <name evidence="2" type="ORF">LDHU3_27.0460</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861895.1">
        <property type="nucleotide sequence ID" value="XM_003861847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID94"/>
    <dbReference type="GeneID" id="13389156"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0460"/>
    <dbReference type="OMA" id="CSEMEHW"/>
    <dbReference type="OrthoDB" id="268604at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="194" mass="21797" checksum="64608C2001816ABB" modified="2019-04-10" version="1">MNVEVTGRCFFTGDDYYISLPITNKAANRGEPRQLLCSEMIHWDDYRQERGINDGKPPMQQLFASSYAEPLVRTFALGNDTYVTQVTGVSATQAGSSSQMFSAEMLHWDDYCAARGIHTGEPTMASLFRPFESKNILVFDLNERKLTEFEGNSVALISYGADRQTYCSEMEHRDDYVRAKTGQAPQPSMASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDL8</accession>
    <name>A0A3Q8IDL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pumillio protein 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250030500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDL8"/>
    <dbReference type="SMR" id="A0A3Q8IDL8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2960"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001266">
        <property type="entry name" value="Pumilio/PUF RNA binding protein 8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001059">
        <property type="entry name" value="Pumillio protein 8, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUM-HD" evidence="2">
        <location>
            <begin position="71"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="573" mass="64698" checksum="3B628C6A82F398F9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDR4</accession>
    <accession>E9BIJ7</accession>
    <name>A0A3Q8IDR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELMO/CED-12 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Engulfment and cell motility domain 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_32230</name>
        <name evidence="5" type="ORF">LDBPK_261850</name>
        <name evidence="4" type="ORF">LdCL_260024100</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861771.1">
        <property type="nucleotide sequence ID" value="XM_003861723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDR4"/>
    <dbReference type="GeneID" id="13389018"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2420"/>
    <dbReference type="OMA" id="HVAHLEM"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="3">
        <location>
            <begin position="203"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="418" mass="45120" checksum="915C01804C24C1FF" modified="2019-04-10" version="1">MAERTSSSTLPSTPLPTSSSRTPHIIAAAVTAAAALGAGILFAVVSSGSAGDGGGSRRAFRSEGAIQEPRQAVVEALEAIRGGRCKTCGELVFFLRGPPQSPVSPAAFRGVLGAASATASEKLPPSNAHCLRVPASVLHYIQESYLPATRRQLVEAQQKQQPSPATPALQVEYNLFAQMVAADVTLRALSVERATPFDKDNRSHMNLLQQLWMAAGKPATTYSPLGQHWASIGFQGVDPVTDLRGGGVLALRQLVHFAQAHNTAFREMLAYNERVQREGKHSWYLLAVVSIQLTTQLMLEQDHPLHVAHLEMIYDTLCLGAAGDATAKTAGRRAVAGQKGVRLGSTRAADTAAFWEFCKSARSAEAGMFALHHALLLHFKECWTRDEPHVMEYNTYMSAKVFSTFFTTKWADKTLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDU8</accession>
    <accession>E9BF30</accession>
    <name>A0A3Q8IDU8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PD-(D/E)XK endonuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_33930</name>
        <name evidence="3" type="ORF">LDBPK_210450</name>
        <name evidence="2" type="ORF">LdCL_210009300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860562.1">
        <property type="nucleotide sequence ID" value="XM_003860514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDU8"/>
    <dbReference type="GeneID" id="13386390"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0470"/>
    <dbReference type="OMA" id="GSFETPC"/>
    <dbReference type="OrthoDB" id="240844at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39499" checksum="2B3038089F727E7D" modified="2019-04-10" version="1">MQPLKRIRHPSGSEILFDAKWHQYKLGGTTLRSVSKLLDRFFPFDEKRVLELVSKKTGQPVDKIKQGWSRQALLGKNVHEFIECKLLKKPPPTFTLLMKRKQAREAARPADATGPAAITTTPLEDEVLHGEEALYLPVAEMAVEKVLSAYDVLGAEQVIAAPGWGIAGTIDFMGRNRRTNRVLIGDWKTTGGVTSNFRFGAFETACPGALRHLPNSKTYRYAMQVIIYGEILAREQYFEKQFFDAQLRASLTASLAVPSTDVMPPAPPAKTRGRPSSRAAAPAKSDIGSDVESLLKTFYHNSTEQRFEYGIVQLAKGEDGGVVAEFKEVTPSTVMPPDCPEMTFDSLLQRVMEGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDV6</accession>
    <name>A0A3Q8IDV6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_260030900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260030900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3230"/>
    <dbReference type="OrthoDB" id="272951at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="625"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="730"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="949"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1478" mass="163356" checksum="7F4F2C279E70E6C2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE95</accession>
    <name>A0A3Q8IE95_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340018800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE95"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2010"/>
    <dbReference type="OrthoDB" id="273756at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="591" mass="62631" checksum="1B5BDF812E16C95D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IED2</accession>
    <accession>E9BLY6</accession>
    <name>A0A3Q8IED2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_302430</name>
        <name evidence="4" type="ORF">LdCL_300029800</name>
        <name evidence="5" type="ORF">LDHU3_30.3280</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862955.1">
        <property type="nucleotide sequence ID" value="XM_003862907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IED2"/>
    <dbReference type="SMR" id="A0A3Q8IED2"/>
    <dbReference type="GeneID" id="13385663"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300029800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3280"/>
    <dbReference type="OMA" id="DSWEWIT"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000004">
        <property type="entry name" value="Peptidyl-tRNA hydrolase PTH2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF25">
        <property type="entry name" value="AMINOACYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18231" checksum="40D0EAD0B1F29DA6" modified="2019-04-10" version="1">MDVDSEYEQMEALRLKMVFVVSSRVQPKITAQEVAVLTASAGVQLVELLQQETKLSAAVSVPASESLCAADSQDHQRWRHWYLWWNRIGCGKITLKCPDKDTMELVVATARKHRLPMAMARRSETAVTGGEQVEIVAKPSDVVVVALGPAPSDVLEPITGSLKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEG2</accession>
    <accession>E9BL24</accession>
    <name>A0A3Q8IEG2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_24965</name>
        <name evidence="7" type="ORF">CGC21_28625</name>
        <name evidence="5" type="ORF">LDBPK_292270</name>
        <name evidence="3" type="ORF">LdCL_290028800</name>
        <name evidence="4" type="ORF">LDHU3_29.3360</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862645.1">
        <property type="nucleotide sequence ID" value="XM_003862597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEG2"/>
    <dbReference type="SMR" id="A0A3Q8IEG2"/>
    <dbReference type="GeneID" id="13385348"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3360"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="445" mass="49749" checksum="B83F745D48A10153" modified="2019-04-10" version="1">MEETYDAIVCGTGLVECVLSGLLSVNGYKVLHVDRNAYYGGESASLNLEQLYQKFNKGTPPASMGRSHLYNVDLIPKVLMCAGELVKILRATVVDRYNMEFMLLDCSFVMKDGKIAKVPATEMEALSSSLMGFFEKRRLRNFLQYVSGYNVKDSRTYKGYNLQTMSMQQLFKEFDLGSDTISFVGHAMALQNNEDYLHKPAIDTVMRCKLYENSFLMYNRSPYVYPLYGSGELPQAFSRLSAVYGGTYMLQTPVDKVNFDANGAFESIESGGKKAFAKLVLGDPSYFPDRVRSCGQVVRCIAIMDHPIPNLKVAANACQIIIPQSELRRRNDVYILQLCEEDKVCPEGKFIVMIGTVVEHPGNPKADLEAGLKLIGPTLETFISVSDLYEPLEDGSTSRCFISKSYDAATHFESAAEDILNLFERIHGKPYSFEAIKRAGEEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEP1</accession>
    <accession>E9BGJ3</accession>
    <name>A0A3Q8IEP1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Qb-SNARE protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Qb-SNARE_protein_putative/GeneDB:LmjF.23.1740</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_231790</name>
        <name evidence="10" type="ORF">LdCL_230025000</name>
        <name evidence="11" type="ORF">LDHU3_23.2360</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861071.1">
        <property type="nucleotide sequence ID" value="XM_003861023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEP1"/>
    <dbReference type="SMR" id="A0A3Q8IEP1"/>
    <dbReference type="GeneID" id="13390509"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2360"/>
    <dbReference type="OMA" id="HETTHDV"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000011">
        <property type="entry name" value="Putative Qb-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5430311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27568" checksum="BE6C3D6685D55F77" modified="2019-04-10" version="1">MSGLFNSYEEDFNDTVRGLREGCSKLQADIDAQSAHEKDPTRIYHPPPATGPLSRAQQLQVVQQSLSHAKDLLTSMMYEMTDLAPSEGAAAKEKVGAFRKICNGLDREVAQLRQSCNAADRTDLLRFGGSAAAGGTGDAFMTEADADTQAHRLLALQTTEKLQGGTSTLRKAEAYLAQTNSLGRESLNTLRTQTEQIAHVQEITNDVDAEISRARVLINQMQRTAIKHKMWLIGIILLLLGFLFFFVYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEQ7</accession>
    <accession>E9BRI4</accession>
    <name>A0A3Q8IEQ7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_20585</name>
        <name evidence="13" type="ORF">CGC21_27215</name>
        <name evidence="12" type="ORF">LDBPK_343860</name>
        <name evidence="10" type="ORF">LdCL_340048000</name>
        <name evidence="11" type="ORF">LDHU3_34.6160</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864545.1">
        <property type="nucleotide sequence ID" value="XM_003864497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEQ7"/>
    <dbReference type="SMR" id="A0A3Q8IEQ7"/>
    <dbReference type="GeneID" id="13387424"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340048000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6160"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000029">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5433983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP40289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP46717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="330" mass="36494" checksum="05F6F5FA5DAD9FAB" modified="2019-04-10" version="1">MAESAAPSGPIVADLHHKFVHELDDNTQWKAQHLKMNGVYWGLSSLVLLHRMDYKPDDVVGFVLSCYNSDGGFGGNADMDSHLLHTMSAVQLLCMFDAVARIDVERTVRWIASMQLPDGSFQGDEWGEVDTRFSYIALSCLRLLGRCECVDVEAAVQYVLRCQNWDGGFGVSPGAESHAGQIFCCVGALCIANALDRIDRDRVAAWLAMRQLPSGGLNGRPEKKADVCYSWWVVSSLSALGRTSWIDKEALFQYILSCQDTQDGGFSDKPGNQPDVYHTFFGLCGLSLLGYEGYKLNPINPVYALSYDILDRLNIAPEHGSQVGRRVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFH8</accession>
    <name>A0A3Q8IFH8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290029400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFH8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3440"/>
    <dbReference type="OrthoDB" id="262453at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36772" checksum="629CEF89A147B861" modified="2019-04-10" version="1">MSTTSSPDAASCDVEKERKCISPVTRTGKSFVECALIDLPEKYSSAFPYLQGARLFFFDVVSKLNRIGARDKRVVFVTDYTIGVASKRGRVSRCAKVEDISELICDAQARALGVRMRSRPFAIAPKDFPRRNCFHEMPVDLLLHATSSAQYEALINVLSFVHHTSTHEALLCRSLKQYETWKASLVLAPDGSRVKKAMQYYAIPVPLSEGSTGAATLSATRSQETSASLWAVRAPRQAALLSAGDSASRFTSAPDVSAAVPTLRHWSSLGASSSFTPSGVGGQRTALELSPFSLSPSPTPPLVGFSRDMVTVPTSATRRGGNPLLKADRKVPNTSSKKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFV6</accession>
    <name>A0A3Q8IFV6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophilic acylated surface protein b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230019500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFV6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1640"/>
    <dbReference type="OrthoDB" id="268333at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="186" mass="19362" checksum="DF283FA1AD3BA196" modified="2019-04-10" version="1">MGTYCTKDSAKKPQKRADNIHKTTEANHRGAAGVPPKHAGGAMNDSAPKEDGHTQKNDGGGPKEDDHAHNDGGGPKEDGHTQKNDGDGPKEDDHAHNDGDGPKEDDHAHNDGGGPKEDDHAHNDGGGPKEDDHAHNDGGGPKEGENLQQNDGDAQEKNEDGHNVGDGANGNEDGNDDQPKEQVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGC5</accession>
    <accession>E9BJ63</accession>
    <name>A0A3Q8IGC5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_32675</name>
        <name evidence="5" type="ORF">CGC21_30765</name>
        <name evidence="3" type="ORF">LDBPK_271310</name>
        <name evidence="1" type="ORF">LdCL_270019800</name>
        <name evidence="2" type="ORF">LDHU3_27.2010</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861984.1">
        <property type="nucleotide sequence ID" value="XM_003861936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGC5"/>
    <dbReference type="GeneID" id="13386718"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2010"/>
    <dbReference type="OMA" id="QCQVLTH"/>
    <dbReference type="OrthoDB" id="268715at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="144" mass="16021" checksum="AFBF90AE13461452" modified="2019-04-10" version="1">MSRVLTVLLTYDDPECGGAADALVEHLERDAVAVEGHCQLSVKPIQVLQNGSHRDALYGSLQDLFQMKPQDIYVIAFLKGSQPEEYRKVNELCNSVRPNPVKCQVLTHLANYNDVGLIIRNLVRLVLDEMTKEEASLGSTEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGI1</accession>
    <name>A0A3Q8IGI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270029200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGI1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3310"/>
    <dbReference type="OrthoDB" id="273639at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1142" mass="119758" checksum="82CD6C5D66644CB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGR0</accession>
    <name>A0A3Q8IGR0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320008600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGR0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0460"/>
    <dbReference type="OrthoDB" id="271408at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="366" mass="38037" checksum="62F7246477779576" modified="2019-04-10" version="1">MQSNYPKQNCGCDFCCSRRSVNATKLAASQAAFQRSGMMQRNGCNCCCHSSGPGGVSPFDPDYPVPVNQTALNASRGRNGVPEGNQYTIRNNSTRAAVPGASQTAGGNGSMKETAEQREAREAAELDALERLLMLEYKARTQATMEAERLKRNATSATTRGPKPVPKGYTSGSTADRMEYSASGAEGRGRTAAGEGSFAPDAFTIHEAYAMAHDCPAEPPAQCHASHRLQDTLDDVRKVTADPVHTGNRRALKQLLHRHGMAEAPTSDNGAATGKAASGTEPNAFGSSLAQIRTSYAHPRGAGLVWVPTAPSAAASQSSMKDSDVVVVERSAAAGAGSAKRPAGLSPGAAAALAADEKQASCAACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II68</accession>
    <accession>E9BV45</accession>
    <name>A0A3Q8II68_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_18795</name>
        <name evidence="6" type="ORF">CGC21_38670</name>
        <name evidence="4" type="ORF">LDBPK_366890</name>
        <name evidence="2" type="ORF">LdCL_360081400</name>
        <name evidence="3" type="ORF">LDHU3_36.9190</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865800.1">
        <property type="nucleotide sequence ID" value="XM_003865752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II68"/>
    <dbReference type="SMR" id="A0A3Q8II68"/>
    <dbReference type="GeneID" id="13386654"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360081400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9190"/>
    <dbReference type="OMA" id="FNWHGSV"/>
    <dbReference type="OrthoDB" id="240666at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="193" mass="22645" checksum="9BC6C6D4BE791434" modified="2019-04-10" version="1">MSGGSGAQGHFMIGKGNGPTSFNWHGSVPTVMVDNCFEPNFRQFDFFLENNEVPNAGLVERVFKPEDGESHWNLRTIMNTNARCTPVLVTSLFGATFVNFLYTRLLNKTGTSVRWSFWTCFAAMLVWNNFTKFVARERYFQRDFQRNQLYSHDELRHQRDQQRVREALYEKNFVTNPVAEYRIKMWQVADRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ69</accession>
    <accession>E9BLF7</accession>
    <name>A0A3Q8IJ69_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Acyl-lipid (7-3)-desaturase</fullName>
            <ecNumber evidence="16">1.14.19.31</ecNumber>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Acyl-lipid 4-desaturase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CGC21_35115</name>
        <name evidence="24" type="ORF">LDBPK_300630</name>
        <name evidence="23" type="ORF">LdCL_300011400</name>
    </gene>
    <organism evidence="23 27">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23 27" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 27">LdCL</strain>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 28">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:88264"/>
            <dbReference type="ChEBI" id="CHEBI:88265"/>
            <dbReference type="EC" id="1.14.19.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:88266"/>
            <dbReference type="ChEBI" id="CHEBI:88267"/>
            <dbReference type="EC" id="1.14.19.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.31" evidence="16"/>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862777.1">
        <property type="nucleotide sequence ID" value="XM_003862729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ69"/>
    <dbReference type="GeneID" id="13385484"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0810"/>
    <dbReference type="OMA" id="YANRTEQ"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000032">
        <property type="entry name" value="Acyl-lipid (7-3)-desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000112">
        <property type="entry name" value="Putative nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="178"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="282"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AYU80859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CBZ36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TPP45632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="537" mass="58612" checksum="ADEC262A7946E5E2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJC9</accession>
    <name>A0A3Q8IJC9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_360030700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJC9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3340"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="275" mass="29877" checksum="D7AC44357B251697" modified="2019-04-10" version="1">MEMLTADDAIVMPLREGAQVPAACIHRFKGPTHGAPVHPPRDRVVLCQAHLCSEHPWCSAEAEPASRWDEIPRPKPRSGLHIALDEVALRFWAVAKTRRAKLFSPQRLCVLRGDGAADPAERLREAVREEKMGEKPLLCTHPPPLVCATRLPYGPLRWAETACLHAIRRLARWRASCRGQATTGATPCQPGSGPGCRGRVCSAAAGAKTQGGGAAGADLHLAVRPAHLTKCCKPTPLSRRLRPSPSRMRRIIRSEDSMAGLGGSVWLDSCRMEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILC3</accession>
    <name>A0A3Q8ILC3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220005100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILC3"/>
    <dbReference type="SMR" id="A0A3Q8ILC3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0050"/>
    <dbReference type="OrthoDB" id="258397at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13989" checksum="A154A4D9422842F3" modified="2019-04-10" version="1">MQYVAEPSSIRVYYRGNKYDVPLEFATRMHPGGSSILMRYKDGDITKDFEKMNHSVDAAVMLNEWLVDGNHFSEVYRSASSCKGGEENGNQQKKESDKSKRWNRLAIAFGCNGFAKPQALKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITQ0</accession>
    <name>A0A3Q8ITQ0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_21390</name>
        <name evidence="5" type="ORF">LdCL_320044100</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITQ0"/>
    <dbReference type="SMR" id="A0A3Q8ITQ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320044100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4850"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000134">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="362" mass="39110" checksum="F63D2181DE95D1B2" modified="2019-04-10" version="1">MHSAVTCIKSPGAALFTDTATCRTITLSRPDALNAMSLPMVQDLHRLYITEPHPNEDAVYVVRGDGRRSFCAGGDLKALTGPEKDTHNPLFYRLEYEVDSHIAVMRRTQVAMWAGHVLGSGVGVSVHSRYRVACETTRFAMPETQIGGANDVATSWVFSSLPICGLGMYLAITGNTLQGADVFHAGLATHYIPVEKFGAVEAALAALPSSEGVEECLRGFSEDVAVPPFTLAENAPVLAKAFGAITPSTHLRDIMDVLRADGSAFAASTLKVMERNSPLGMTLALENMKRQHTPGCNTVMESFRGDYTAIQTSICVDELAKGVEALFVTKEKRPQWTVGSVDEVDVELVKQQFVMTESTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Z7</accession>
    <name>A0A3S5H4Z7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_020008400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0410"/>
    <dbReference type="OrthoDB" id="266243at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1315"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1539" mass="167064" checksum="C743EF1EC29A87F1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H562</accession>
    <name>A0A3S5H562_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDP-alcohol phosphatidyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_030013300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H562"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0900"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="618" mass="68262" checksum="05D663FC55E00F96" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H564</accession>
    <name>A0A3S5H564_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_030013800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0950"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001344">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF70">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="710"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="898"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1388" mass="148761" checksum="4A3D4AB7BBE539DB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5I9</accession>
    <name>A0A3S5H5I9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine Rich repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050011600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5I9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0730"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="91733" checksum="B4E40FE677DC7CF4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5L8</accession>
    <name>A0A3S5H5L8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 4-phosphate 5-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_050016100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5L8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_051080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1200"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="726" mass="80303" checksum="8C4FC008DF62E107" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H610</accession>
    <name>A0A3S5H610_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoplasmin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_10535</name>
        <name evidence="3" type="ORF">LdCL_070016100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H610"/>
    <dbReference type="SMR" id="A0A3S5H610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070016100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1340"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="118" mass="12844" checksum="CE33B9EBD04047F0" modified="2019-04-10" version="1">MEEFYGMEVFAGKTARPNISADRVLHVTQVALPPNASHAITLLVKTEGKSFVLATLDPQQALFHVSVDMLFSGKQKLAFTCEGAAGAVHIIGYTQLAEEEEAIDDEDDDDMMDDEDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6I7</accession>
    <name>A0A3S5H6I7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription modulator/accessory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_110011100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6I7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0750"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.310:FF:000002">
        <property type="entry name" value="Putative transcription modulator/accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000001">
        <property type="entry name" value="S1 RNA-binding domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000019">
        <property type="entry name" value="Transcription modulator/accessory protein,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqgF/RNase H-like" evidence="2">
        <location>
            <begin position="458"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118230" checksum="32FEA21CE3E5579B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J2</accession>
    <accession>E9BAS8</accession>
    <name>A0A3S5H6J2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L24, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">60S_ribosomal_protein_L24_putative/GeneDB:LmjF.11.0900</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal protein L24e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_30995</name>
        <name evidence="11" type="ORF">CGC21_0805</name>
        <name evidence="9" type="ORF">LDBPK_110900</name>
        <name evidence="7" type="ORF">LdCL_110014500</name>
        <name evidence="8" type="ORF">LDHU3_11.1120</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859066.1">
        <property type="nucleotide sequence ID" value="XM_003859018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J2"/>
    <dbReference type="SMR" id="A0A3S5H6J2"/>
    <dbReference type="GeneID" id="13389540"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1120"/>
    <dbReference type="OMA" id="IWPSCKE"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP39870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="190" mass="22595" checksum="3C850859FC5C362A" modified="2019-04-10" version="1">MRIEQCSFCSAPIYPGHGQVFVRNDCKVFRFCSSKCRKNFGMKRNPMKLKWTKTFRKANGKELAVDSTMDFEQRRNIPVKYNRELLGDTLKVMKRVEKIKQRRQEDLWARRMEKARLQEKQEAASALKHNIDWIEDVEIKHKARDDLVAIQQEREDKKAKRREANKKRHQKQRLAEKATGTSAFRSAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J7</accession>
    <name>A0A3S5H6J7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transport protein SEC31, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_110017400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1380"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001134">
        <property type="entry name" value="Protein transport protein Sec31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018754347" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU76885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1167" mass="123223" checksum="BB8ECA28A0E3E466" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6T5</accession>
    <accession>E9BC46</accession>
    <name>A0A3S5H6T5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="11">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_150050</name>
        <name evidence="13" type="ORF">LdCL_150005400</name>
        <name evidence="14" type="ORF">LDHU3_15.0060</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859530.1">
        <property type="nucleotide sequence ID" value="XM_003859482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6T5"/>
    <dbReference type="SMR" id="A0A3S5H6T5"/>
    <dbReference type="GeneID" id="13392988"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0060"/>
    <dbReference type="OMA" id="LDMKGPF"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5428702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="279" mass="31511" checksum="EAE0543525003854" modified="2019-04-10" version="1">MWSTTQQSEHLAAKCAKKPVNTFSPDSYKPFKLISSRYESHDTRRFYFALDSPDDSFYMPVASCIIAKYTDADGKDVARPYTPISSNSTKGHFELVVKKYPKGKMGNYLFSMQPGDELLVKGPFEKFAYKPNMWKHVGMIAGGTGISPMYQVIRAVLENPKDKTNISLIYANNQRRDILLANELIEMQKVYNNFNMYLTLLEVPHRWLGGIGYVNSAMVTTFMPKPGEKNTKILVCGPPPMMQAISGDKLFEPGKPPQQGQVSGLLKTLGYTEEQVFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7H3</accession>
    <name>A0A3S5H7H3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_33180</name>
        <name evidence="14" type="ORF">CGC21_31270</name>
        <name evidence="12" type="ORF">LdCL_270008800</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7H3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0480"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP47612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="730" mass="80840" checksum="5AC5B8A8091F870D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7X9</accession>
    <name>A0A3S5H7X9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Expression site-associated protein 5 (ESAG5), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340046800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7X9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6010"/>
    <dbReference type="OrthoDB" id="260782at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018782199" evidence="1">
        <location>
            <begin position="47"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="548" mass="59913" checksum="058A4EE296996FEB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNX8</accession>
    <name>A0A3S7WNX8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_9590</name>
        <name evidence="1" type="ORF">LdCL_040017200</name>
        <name evidence="2" type="ORF">LDHU3_04.1410</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812624">
        <property type="protein sequence ID" value="CAC5427248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000063">
        <property type="protein sequence ID" value="TPP43049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNX8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1410"/>
    <dbReference type="OrthoDB" id="269031at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="168" mass="19238" checksum="F91E35A53F84F7E6" modified="2019-05-08" version="1">MPPKFTHPRLVHHVSLFTRVKAWWLGIENPEVLSRYGERGVARTVWIEWRGTLAMCAGGFVLFIGRQQSKRANDILDNIELNRQRFYQRDFTPTYVPDAPSGVYDGVRGYSYRDEPSGLMINADNKLVSDESRAARGERLAKTEVTPEMVAQARNLLHSRRYEGTPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPH1</accession>
    <name>A0A3S7WPH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060012300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0840"/>
    <dbReference type="OrthoDB" id="250979at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2156"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2167"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2187"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2236"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2300"/>
            <end position="2318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2354" mass="253725" checksum="0DDEB141FCB25CDA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ20</accession>
    <accession>E9B9M4</accession>
    <name>A0A3S7WQ20_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY4 N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_0585</name>
        <name evidence="4" type="ORF">LDBPK_080040</name>
        <name evidence="3" type="ORF">LdCL_080005300</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858569.1">
        <property type="nucleotide sequence ID" value="XM_003858521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ20"/>
    <dbReference type="GeneID" id="13391902"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0050"/>
    <dbReference type="OMA" id="YWQETSA"/>
    <dbReference type="OrthoDB" id="270849at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY4 N-terminal dimerisation" evidence="2">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="229" mass="25291" checksum="92ECD96378F1FB05" modified="2019-05-08" version="1">MDLADNSMWTLVEEAVIEDRGEDEEEVLAQMVRSYLARRGLTDTLAAFDEEHQCYRGSSTAPHNRDPGAPRPSVDAEVLGSTPATDRASAGSAPPRDETSAGMDKRKAAQLLCLQKRYEAAAALMEPSSLARIRLLCIQAQSLEDRPTAVFYLATHVAPLVPFCIDPTMGHRVYTAALSNVLSPCRERSIPDTELLAREVNDELCGREQRSSLHVLFNWAYWQETSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQK8</accession>
    <name>A0A3S7WQK8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (Many copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090009100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQK8"/>
    <dbReference type="SMR" id="A0A3S7WQK8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0510"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000935">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="210" mass="22692" checksum="30A54A5500BB446C" modified="2019-05-08" version="1">MSTTAPATSMGPLPYPNALQSRHTTTEQRQIAAAAVRAYQSTLEQEKVLLQENDALLSEEEAGRLQRRVDNQAAADATAAQFRDRACKVVASVPDEQYRSEGGAIDIFHAACDGDVAALDACLRSASNIDALGQPDPARYNGFQFKQRWLFRAPPLVFAAAFGREEAVRFLLEHGANPHVASTTGLRAQDYAAQRGYSAIVLMLTSGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQV4</accession>
    <name>A0A3S7WQV4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_090020300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQV4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1640"/>
    <dbReference type="OrthoDB" id="271677at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007824">
        <property type="entry name" value="Flagellar_rod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053120">
        <property type="entry name" value="PFR_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732">
        <property type="entry name" value="69 KDA PARAFLAGELLAR ROD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732:SF4">
        <property type="entry name" value="ROD COMPONENT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05149">
        <property type="entry name" value="Flagellar_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="605" mass="68095" checksum="879CFD708A81FD56" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSV8</accession>
    <name>A0A3S7WSV8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Amastin_surface_glycoprotein_putative/Pfam:PF0734 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_38705</name>
        <name evidence="4" type="ORF">CGC21_4655</name>
        <name evidence="2" type="ORF">LdCL_140010300</name>
        <name evidence="3" type="ORF">LDHU3_14.0660</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSV8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0660"/>
    <dbReference type="OrthoDB" id="272145at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="274" mass="30330" checksum="86775FF3E2731D82" modified="2019-05-08" version="1">MRTGTNANCEPLTEISSLRTSRRPSSLHRRKSKIGGRTVLYIPCRERVLIALAATMQVITFVLLIAAAATDVFMVDGTRAIRIGADLKAVSAGLGVSVTEGSKPFCYSLWGARKCGTSTFHTEKWYTEHGIKNKGFPSSVTYTMMLGAAAFAVLASCYSFINIIGITIVVCMQDFTAVLCAWSFSVWIIILISWALSVGVYARSMETMNSTIVGRKVRVKDYCDFSSSFALIMTAFALQGFQFTFTAVYTRMFENRMKSLVAEQKQINRELSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTF1</accession>
    <name>A0A3S7WTF1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_150005000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTF1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0010"/>
    <dbReference type="OrthoDB" id="257350at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000058">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11325" checksum="DA51E52CB09D1D38" modified="2019-05-08" version="1">MAKGKRSADAKSSQKRQKKVLRDNIRGITRGCVGRMARRGGVKRISSEVYEEVRRVLKAYVEDIVRCSTAYTEYARKKTVTACDVVNALRKQGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUI7</accession>
    <name>A0A3S7WUI7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170015800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUI7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1410"/>
    <dbReference type="OrthoDB" id="272324at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="561" mass="61250" checksum="305356D2551C4444" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVM9</accession>
    <accession>E9BEB0</accession>
    <name>A0A3S7WVM9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_8740</name>
        <name evidence="11" type="ORF">CGC21_19025</name>
        <name evidence="9" type="ORF">LDBPK_191180</name>
        <name evidence="7" type="ORF">LdCL_190016900</name>
        <name evidence="8" type="ORF">LDHU3_19.1420</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860293.1">
        <property type="nucleotide sequence ID" value="XM_003860245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVM9"/>
    <dbReference type="SMR" id="A0A3S7WVM9"/>
    <dbReference type="GeneID" id="13386105"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1420"/>
    <dbReference type="OMA" id="QVTAVWE"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="6">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="130" mass="15143" checksum="3F4A7ECB4563F9EE" modified="2019-05-08" version="1">MANGVTANSMRVTAKPPDLGSFPLDHYRECKSEIEKYYACLKENNYMTPMCRDPVREYLECRMDRGLMKKTDVKSFGIPETEFVPTKQHRIDLKEQWLRQKMNQIGVVGVENYIRDDLDTPDGYEKEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW30</accession>
    <accession>E9BET0</accession>
    <name>A0A3S7WW30_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_29190</name>
        <name evidence="3" type="ORF">LDBPK_201310</name>
        <name evidence="2" type="ORF">LdCL_200017700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860472.1">
        <property type="nucleotide sequence ID" value="XM_003860424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW30"/>
    <dbReference type="GeneID" id="13386257"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1630"/>
    <dbReference type="OMA" id="HFATIDP"/>
    <dbReference type="OrthoDB" id="272440at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="189" mass="20399" checksum="23CC827696B47DD0" modified="2019-05-08" version="1">MGCGSSAPKADTSASTEEVRALSVDMKTHFANIDPEVLGPHKESAKAKLAFMYGKTANIFLLTTEPFHKPHHQPKPEGEEHAPEDDEKQASAVEEIRWTLFNDGKSDATVEATFFRAEALRPARAHGAAEDAESPVKLEFSDGGCVKAKVSVPAGATVAFVEGPIKGYMWKCMVLDPKTSRFEPALAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWG1</accession>
    <accession>E9BF62</accession>
    <name>A0A3S7WWG1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette protein subfamily E, member 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_34055</name>
        <name evidence="7" type="ORF">LDBPK_210770</name>
        <name evidence="6" type="ORF">LdCL_210012600</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860594.1">
        <property type="nucleotide sequence ID" value="XM_003860546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWG1"/>
    <dbReference type="GeneID" id="13386407"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0830"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="78"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="352"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP49303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="659" mass="74048" checksum="2919C4BF4A7B2DB4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWY7</accession>
    <name>A0A3S7WWY7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_34685</name>
        <name evidence="7" type="ORF">LdCL_210027200</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWY7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2610"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000004">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP49429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="249" mass="28292" checksum="4C6208682548C7DE" modified="2019-05-08" version="1">MKLNIAYPRNGTVKQFEISDEVLRRVQLQDYRLGNEVDGAIFGSEFKGYIFRLRGGSDKDGFPMVPGVLASSRVSLLVKRGAIGFNTFRGYQGERRRKNVRGCVLASDIALVNVTISKVGDQPIEGVTDTTAPRRLGPKRASKIRKLFNLSRTEDVRKYVVRRRVVKSGKKDRLKAPKIQRLITPRVKSRRAKKAKDAIAKVRASAAERREYLRLIASNRRALRQRDHSKKHTQKVHAQRAEVAAFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXD9</accession>
    <accession>E9BFZ1</accession>
    <name>A0A3S7WXD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centrin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Centrin-4, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Centrin-4_putative/GeneDB:LmjF.22.1410</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">EF hand family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_16155</name>
        <name evidence="7" type="ORF">CGC21_2065</name>
        <name evidence="6" type="ORF">LDBPK_221260</name>
        <name evidence="4" type="ORF">LdCL_220019700</name>
        <name evidence="5" type="ORF">LDHU3_22.1810</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860872.1">
        <property type="nucleotide sequence ID" value="XM_003860824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXD9"/>
    <dbReference type="SMR" id="A0A3S7WXD9"/>
    <dbReference type="GeneID" id="13389595"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1810"/>
    <dbReference type="OMA" id="EIMTAKM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000331">
        <property type="entry name" value="Ca2+-binding EF-hand protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000340">
        <property type="entry name" value="Centrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP46943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="149" mass="16448" checksum="F1196A921F565830" modified="2019-05-08" version="1">MAALTDEQIREAFNLFDADGSGAIDAEEMALAMKGLGFGDLSRDEVERIIRSMHTDSNGLVAYGEFEAMVKSRMAQKDSPEEILKAFQLFDLDKKGKISFANLKEVAKLLGENPGDDVLKEMIAEADEDGDGEVSFEEFKSVMLQMRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXR6</accession>
    <name>A0A3S7WXR6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_18010</name>
        <name evidence="2" type="ORF">LdCL_230018800</name>
        <name evidence="3" type="ORF">LDHU3_23.1520</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXR6"/>
    <dbReference type="SMR" id="A0A3S7WXR6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1520"/>
    <dbReference type="OrthoDB" id="261955at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38148:SF3">
        <property type="entry name" value="BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="306" mass="34423" checksum="87331570A540512D" modified="2019-05-08" version="1">MGNKISSADQSNADDRGVHSEFVYRYETTKKLKLSYMMLKKNVATAVMTMEITPQHLRDVGTGYSNVCACLKHGGSGGANSRIQGRAEGRDQAPTSRSRVDRELADESYQGFQTFCEAMDDIKTGVCVTCRTAIHERITVELDRMVLTAERVLKQGRKTMRSMARLTKVARQVSRRERSAVSQGKDLSSSKSYAKAVKRRDAKESLYKTELEAFDQLYENVMVGSQEFCSSTTDIFLDCIVGYYREIVTTIDVSDTPQCSRLRSRFRSREREVVLHQASDARFCEMPAGHKDGSKSSPSTVPLKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYM3</accession>
    <name>A0A3S7WYM3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_240029500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYM3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2950"/>
    <dbReference type="OrthoDB" id="263891at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25525" checksum="711691E1C30DD607" modified="2019-05-08" version="1">MERYESIAGRAGFARSRVLPRRSDASSSASVCYENAANYLQHARGADCATASSSVPVDVWDALCQAEASVLRVGQLIEGWQRLVAYEGCTTSSHTSDLSSRLASLEKSLDKLLSEFPKTAEELVTLDYNTSLCSAGARSVLTAVPSFLSITASLRTINSKLCSLDGFSREVLPLMRCEDNVSRQCLLVANRLDRLEEKLSTAEALVAALGRTSAASNAIFERIGIRYEDITRAAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYQ2</accession>
    <accession>E9BH93</accession>
    <name>A0A3S7WYQ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical predicted multi-pass transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_16730</name>
        <name evidence="3" type="ORF">LDBPK_242320</name>
        <name evidence="2" type="ORF">LdCL_240028800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861320.1">
        <property type="nucleotide sequence ID" value="XM_003861272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYQ2"/>
    <dbReference type="TCDB" id="2.A.110.2.1">
        <property type="family name" value="the heme transporter, heme-responsive gene protein (hrg) family"/>
    </dbReference>
    <dbReference type="GeneID" id="13391480"/>
    <dbReference type="KEGG" id="ldo:LDBPK_242320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2870"/>
    <dbReference type="OMA" id="TFRIWLA"/>
    <dbReference type="OrthoDB" id="243763at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="175" mass="19984" checksum="BB8C614528BFDCFE" modified="2019-05-08" version="1">MNELERKRRTFRIWLAIYIIFALAYLSGVLLFCFVHQNYWACGGFVVVILLIALRVALLATPQYRLYKIFPPCSFSRIAYQTFFLCACLVGISLGVWLMARGIKHRQSWTARSYFCGMTGMWMAAKWSYIVTVPIYDLREDTLEEDALIRLGLIDSGKDKASGSNEPVTLKANCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ58</accession>
    <name>A0A3S7WZ58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_250021900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ58"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2060"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="231"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="863" mass="94496" checksum="AD25BEC295B91D04" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X019</accession>
    <accession>E9BII5</accession>
    <name>A0A3S7X019_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32175</name>
        <name evidence="3" type="ORF">LDBPK_261730</name>
        <name evidence="2" type="ORF">LdCL_260022900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861759.1">
        <property type="nucleotide sequence ID" value="XM_003861711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X019"/>
    <dbReference type="GeneID" id="13389006"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2170"/>
    <dbReference type="OMA" id="NGNWSEV"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="516" mass="56073" checksum="361EF66A04F3B406" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0Z3</accession>
    <accession>E9BJE2</accession>
    <name>A0A3S7X0Z3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosducin/Thioredoxin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosducin/Thioredoxin_putative/Pfam:PF02114/Pfam: PF00085</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_32265</name>
        <name evidence="7" type="ORF">CGC21_30375</name>
        <name evidence="5" type="ORF">LDBPK_272120</name>
        <name evidence="3" type="ORF">LdCL_270028500</name>
        <name evidence="4" type="ORF">LDHU3_27.3240</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862063.1">
        <property type="nucleotide sequence ID" value="XM_003862015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0Z3"/>
    <dbReference type="SMR" id="A0A3S7X0Z3"/>
    <dbReference type="GeneID" id="13386798"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3240"/>
    <dbReference type="OMA" id="FEGCATE"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000435">
        <property type="entry name" value="Phosducin/Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="239" mass="27340" checksum="8233960E07C10B31" modified="2019-05-08" version="1">MLGSGKSSGVVNEASNLKANENLTATIEQMNSKAYRQSRDMNDVIPTHRRPVTEAVRDNGVPVYDPAAEKHAEKVERGNAAGAEDDDDELMELRRMRLQCMRANQEKQAEWRSKQHGEYREISQDDFFNIVVREKGGSERVCVHFYHKDFETCKVMDRRLSELSRTLLAVKFVKIDAERSPFLVERLRVTTLPHCLLFFNDVCIDRIVGFQGCVTEDGTLDANLLRERIVHALKLKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X104</accession>
    <accession>E9BJF7</accession>
    <name>A0A3S7X104_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_32195</name>
        <name evidence="6" type="ORF">CGC21_30305</name>
        <name evidence="4" type="ORF">LDBPK_272270</name>
        <name evidence="2" type="ORF">LdCL_270030100</name>
        <name evidence="3" type="ORF">LDHU3_27.3420</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862078.1">
        <property type="nucleotide sequence ID" value="XM_003862030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X104"/>
    <dbReference type="GeneID" id="13386813"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3420"/>
    <dbReference type="OMA" id="DWGDMVL"/>
    <dbReference type="OrthoDB" id="262426at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="160" mass="17913" checksum="E9DB1E4997A067B5" modified="2019-05-08" version="1">MSQSNDDWGDMVLPGVYMIQRSTGSGMTSGTVPPDKAVNLELIHLEIEETEEYIELLQRSNNEIAAYLKEQRESRFAEEEGGVGTSMIELSDGGLEEEDDDAVFREALEENALVIARKKKELEQLRALISEQRCGCSCAHTQHHNPQPIAAPRNETRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1K1</accession>
    <name>A0A3S7X1K1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_280024000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1K1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2510"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="162"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="842"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="867" mass="96255" checksum="D8204F161E7C6DE4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1M7</accession>
    <name>A0A3S7X1M7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_280023100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2400"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000083">
        <property type="entry name" value="Sulfate transporter-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="438"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1056"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1713"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1838"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1912"/>
            <end position="1921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1990" mass="215909" checksum="D32AE9882D1801D3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X263</accession>
    <accession>E9BKH6</accession>
    <name>A0A3S7X263_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc-finger of a C2HC-type family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Zinc-finger of a C2HC-type, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Zinc-finger_of_a_C2HC-type_putative/Pfam:PF13913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_27695</name>
        <name evidence="10" type="ORF">LDBPK_290300</name>
        <name evidence="8" type="ORF">LdCL_290007800</name>
        <name evidence="9" type="ORF">LDHU3_29.0400</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862447.1">
        <property type="nucleotide sequence ID" value="XM_003862399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X263"/>
    <dbReference type="GeneID" id="13387186"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0400"/>
    <dbReference type="OMA" id="RHAITCE"/>
    <dbReference type="OrthoDB" id="10255185at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF36">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5431738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP52664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="383" mass="40786" checksum="231E21941974FC90" modified="2019-05-08" version="1">MSATRDGPRSHSDGGFDGRSLLSEQTKLLRESTPADINFIQFLKLRLSAQQRATAQRNYWQRVQREAADSMNPNTARWQGRGGIPASAAPISTAAASSVEGASFSTYDAEHVILEHSTTSFGTLPRQDALMRATSHGAVTPPTVHQHSFEDLPAAVLKRRGAPASELTDFVAVSTTEPSEDGNSSQRRPSGPLPEEDAYVLAPFSTSSYSAAAAAAIDERPAMACGKPQVPVDVDEMKDVELEPCPHCGRTFAPARLERHVATCERHKNTLPKTKGDMKSGRARSGRKKPDRTAGGDGAAASADATANAPGAAPGGPQRWPTDTAFKPEKWRKQSAQLRNAMAGASVAVDDDRVPCPSCGRHFSDDVAARHIPICKSKGGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3B0</accession>
    <name>A0A3S7X3B0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MA3 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_300017300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3B0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1580"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000128">
        <property type="entry name" value="MA3_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="4">
        <location>
            <begin position="569"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="860" mass="94346" checksum="2EF1E9699E401751" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3R1</accession>
    <accession>E9BM11</accession>
    <name>A0A3S7X3R1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Triose-phosphate Transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Triose-phosphate Transporter family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_36055</name>
        <name evidence="9" type="ORF">LDBPK_302680</name>
        <name evidence="8" type="ORF">LdCL_300032400</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862979.1">
        <property type="nucleotide sequence ID" value="XM_003862931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3R1"/>
    <dbReference type="GeneID" id="13385688"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3580"/>
    <dbReference type="OMA" id="NSLYTIW"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600682" evidence="6">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="15"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP45820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="325" mass="36140" checksum="9B5007C128506AC2" modified="2019-05-08" version="1">MSTASLLFSLLLNITSSIGVIIVNKRFVFVEAHFEFSTVLTIIHFTTTFLGCVFFAYGAKLFTPKKLSIRRVLPISCAFCGYVVFNNLSLLTNSVSVYQVLKILCTPMIVLVERVHYGKREKLSTLLSLLPVCIGVGVTFYADTDVNWMGTVWAFLAIIANSLYTIWGKTKQVELGAQPMQLLIYETPLSAVMLLLVVIPLDGGEKLAAYEVTFKTVWTVLLSCIFAFGVNFSFFLFVGKTSPLTMNVVGYLKTSLVFVLDFIFVSANMPQKKLIGISLTLLGLAGYSYSKIESPLPRSPTIWRNSRQSSPYQRHRGAEVKVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4H3</accession>
    <name>A0A3S7X4H3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_310022700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2740"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002111">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="769"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="936"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1338"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1764"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1848"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2178"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2250"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1358"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1425"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1769"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2187"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2265"/>
            <end position="2283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2283" mass="239217" checksum="13A960967388D205" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X763</accession>
    <name>A0A3S7X763_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330039000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X763"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330039000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4630"/>
    <dbReference type="OrthoDB" id="277748at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1052" mass="114621" checksum="006519296953606A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7J3</accession>
    <name>A0A3S7X7J3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340011400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0990"/>
    <dbReference type="OrthoDB" id="191673at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048732">
        <property type="entry name" value="CFA69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14716:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1749" mass="185778" checksum="4C3CB6D8BECF1CDF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X888</accession>
    <name>A0A3S7X888_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340037100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X888"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1250"/>
    <dbReference type="OrthoDB" id="264567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="636" mass="71403" checksum="F6206EF6E028C040" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8M6</accession>
    <accession>E9BRP3</accession>
    <name>A0A3S7X8M6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_0880</name>
        <name evidence="17" type="ORF">CGC21_5675</name>
        <name evidence="16" type="ORF">LDBPK_350110</name>
        <name evidence="14" type="ORF">LdCL_350006100</name>
        <name evidence="15" type="ORF">LDHU3_35.0180</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864604.1">
        <property type="nucleotide sequence ID" value="XM_003864556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8M6"/>
    <dbReference type="SMR" id="A0A3S7X8M6"/>
    <dbReference type="GeneID" id="13387482"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0180"/>
    <dbReference type="OMA" id="MNCLFES"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000033">
        <property type="entry name" value="Coatomer zeta subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU82811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5434039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ37922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP44302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP46518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="184" mass="20171" checksum="15793FBD790AF1D5" modified="2019-05-08" version="1">MAFLHRVQAVVALNNTGSRIFAKYFIGEGTPESSKALAPLEKQRSLEHAVFQAIHDPRRGNHVAYESEILVVEGHIALFHISEDVTIIVIGAGSENEVVLSNVLMGLVDALRQELNTPSLTARLLLENYCALLMTIDEMLDEGIILETDSATVANDLEPYLVDVSNDTARAALTGVNKYLRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8W1</accession>
    <accession>E9BRP6</accession>
    <name>A0A3S7X8W1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_0865</name>
        <name evidence="5" type="ORF">CGC21_5690</name>
        <name evidence="4" type="ORF">LDBPK_350140</name>
        <name evidence="2" type="ORF">LdCL_350006400</name>
        <name evidence="3" type="ORF">LDHU3_35.0210</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864607.1">
        <property type="nucleotide sequence ID" value="XM_003864559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8W1"/>
    <dbReference type="GeneID" id="13387485"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0210"/>
    <dbReference type="OMA" id="RCQVNRA"/>
    <dbReference type="OrthoDB" id="268470at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="119" mass="14456" checksum="8EBC674BD07E0DE3" modified="2019-05-08" version="1">MLRHSLLRCQMNRAPARPGPTLYGWGRTEQKRRLEYEATESKYHKRDFNKSWDVAGVEQRYSDFMQVRTYFSIGSRWGTWLYNMIQFYVLSMLPIFAFMHFLHKSIEAYDDSIRKAAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X910</accession>
    <name>A0A3S7X910_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350020100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2030"/>
    <dbReference type="OrthoDB" id="272599at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="619" mass="68964" checksum="2705923EC5C1BD27" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X933</accession>
    <accession>E9BS47</accession>
    <name>A0A3S7X933_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_351720</name>
        <name evidence="12" type="ORF">LdCL_350022100</name>
        <name evidence="13" type="ORF">LDHU3_35.2260</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864756.1">
        <property type="nucleotide sequence ID" value="XM_003864708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X933"/>
    <dbReference type="SMR" id="A0A3S7X933"/>
    <dbReference type="GeneID" id="13387636"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2260"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="372" mass="42572" checksum="9CF2E17EBCAAE562" modified="2019-05-08" version="1">MSSRSSPKSPASDGAHRYAHVNVNKPSSYWDYDSLRVQWNSPDRYEVVQKIGRGKYSDVFLGVDTKVPRQVVIKVLKPVKKKKILRELMVLQTLKGGPNIVDLFDVVREPNSKTPSFVFEYVKSCDFRTVFPTFTDLEVRSYIFQVLMALEYAHSHGIMHRDVKPNNVCLDYKTGKLKLIDWGLAEFYHPATSYNARVASRYFKGPELLVELPMYDYRLDMWSLGCMLAAMIFIREPFFRGKDNTDQLVRIVKVLGTDDLQVYLKKHNASLPPVLEATLGYHAKKPWRSFVNGQNEHLCPPEALAFLDKLLQYDHMKRIQAAEAMMDPYFDPVRPKDFTLDGITVAAENGGGGASVCNEENVHEKRVPRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9K2</accession>
    <accession>E9BSL3</accession>
    <name>A0A3S7X9K2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_15030</name>
        <name evidence="7" type="ORF">CGC21_7175</name>
        <name evidence="6" type="ORF">LDBPK_353420</name>
        <name evidence="4" type="ORF">LdCL_350039200</name>
        <name evidence="5" type="ORF">LDHU3_35.4500</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864922.1">
        <property type="nucleotide sequence ID" value="XM_003864874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9K2"/>
    <dbReference type="SMR" id="A0A3S7X9K2"/>
    <dbReference type="GeneID" id="13387799"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350039200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4500"/>
    <dbReference type="OMA" id="FIRDAGH"/>
    <dbReference type="OrthoDB" id="278017at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="947"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="1084" mass="117296" checksum="6B65B6F771379E01" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBF7</accession>
    <accession>E9BUE2</accession>
    <name>A0A3S7XBF7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14450</name>
        <name evidence="3" type="ORF">LDBPK_364340</name>
        <name evidence="2" type="ORF">LdCL_360050500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865548.1">
        <property type="nucleotide sequence ID" value="XM_003865500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBF7"/>
    <dbReference type="GeneID" id="13388434"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360050500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5860"/>
    <dbReference type="OMA" id="LAMLCEL"/>
    <dbReference type="OrthoDB" id="272410at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741:SF1">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40741">
        <property type="entry name" value="AMASTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="199" mass="21964" checksum="CAC71EDA8ED2D93B" modified="2019-05-08" version="1">MLIIRFVLLVLILVFFVVALVGTVSLPLYSNRITSYNQDGKVEVSLWNIVVGKVTVTGENSTNVPTSMPVRINYAGCEEFRATFRAMQAFAIGGTVFGFYALLVSCLQCFCRLKVKLPLFLFLFLAMLCELCVVFIGGAAYSKEFCKNLDKNGNLTTIIFKGAGYKLDTAFILQVVALVGYAICTIITPFTQQLWCGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBG4</accession>
    <accession>E9BUE1</accession>
    <name>A0A3S7XBG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14445</name>
        <name evidence="3" type="ORF">LDBPK_364330</name>
        <name evidence="2" type="ORF">LdCL_360050400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865547.1">
        <property type="nucleotide sequence ID" value="XM_003865499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBG4"/>
    <dbReference type="GeneID" id="13388433"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360050400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5850"/>
    <dbReference type="OMA" id="TIRIMNI"/>
    <dbReference type="OrthoDB" id="271757at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="237" mass="26849" checksum="AD3D5E6635B9C457" modified="2019-05-08" version="1">MGRLDHRAEDKRSCGGRVVDALCSVFSLRIALSIIYFILVVLLCIMQDISLFSTPTIRIMNIEASHIVGAKTFIADTWFKVDQSIYGANVTGRIDVKLWVTKINMNVEIPYGYVPQNISQVYRVQDVPCAEFRNFFRCMQIFSLLSIFTGFIVWVFTVSNFFTRMFLPLLWLFLWVTIAFTATTVAMMLRVLCDGACYGEVDEIPPFTALATPMGGFALAFISLQTYLVTSIMTVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBN7</accession>
    <name>A0A3S7XBN7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin protein ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360053000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360053000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6200"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="2153"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="682"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1777"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2210"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2222"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="2539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2572" mass="277709" checksum="38678E29CC424684" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBV9</accession>
    <name>A0A3S7XBV9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">32 kDa ER-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360060000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBV9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360060000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7060"/>
    <dbReference type="OrthoDB" id="269997at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019392833" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="260" mass="30239" checksum="97A939486DA3A3E5" modified="2019-05-08" version="1">MGTRLHFTVGRVCLAMSSSLFLCSAVLHDRAFEQHWDYSKPTLRKRTHYFDFWRSAFYSPVLSREERECLDVWLSILAVHSPMFATIQLSPKAILQDSMAMLQGVSELRDGVYLLEKLPIRVEPYLQEIRREIQDEVVFLHGKTRTDIYLIVPFTSYSIPLFVFPASFTLQLERTHTNGHLHITTAEHRWFSGLICSHQTNSVASPWGDVGDLCRRYNGFLWSLMVTKKISLDERRRALATRAAEIEADLREQQERQISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC60</accession>
    <name>A0A3S7XC60_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tartrate-sensitive acid phosphatase acp-3.2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_360076000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC60"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360076000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8990"/>
    <dbReference type="OrthoDB" id="258799at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019126944" evidence="4">
        <location>
            <begin position="24"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="451"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU84040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110790" checksum="AD1C0D3C1FDFDA26" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XCE4</accession>
    <name>A0A3S7XCE4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sperm tail/Sperm tail C-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_360081500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DRC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XCE4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360081500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9200"/>
    <dbReference type="OrthoDB" id="10260459at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="5">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="6">
        <location>
            <begin position="563"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU84095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="648" mass="75263" checksum="F87A8000CFF847AF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJK4</accession>
    <name>A0A451EJK4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 58 central coiled coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_020012300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJK4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3740"/>
    <dbReference type="OrthoDB" id="264785at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF24">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="455"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="772"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU75672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="937" mass="106384" checksum="FA24A893E72D014F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E9B842</accession>
    <accession>A0A3S5H5C6</accession>
    <name>E9B842_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nascent polypeptide associated complex subunit-like protein, copy 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_040770</name>
        <name evidence="3" type="ORF">LdCL_040013300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858139.1">
        <property type="nucleotide sequence ID" value="XM_003858091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B842"/>
    <dbReference type="GeneID" id="13390987"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0990"/>
    <dbReference type="OMA" id="TQHAQMS"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="PhylomeDB" id="E9B842"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18206" checksum="8D2B76D921BA61C3" modified="2011-04-05" version="1">MSVEEAQNAAAMADEEIPTLEAAEVPQNAKQSKRYAKAMAKMGLKPEPNITKVTIRKVGSLSFAMVQPEVYRFPGTNTFVIFGEAQLEDTSALAQEAAARAAVSGAASASSDAAASVPAAEEDDDEEVDAGDLDEKEINVVMSQANVSRNKAIKALKNNNGDIVNTIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8A7</accession>
    <accession>A0A3S7WNZ4</accession>
    <name>E9B8A7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_050170</name>
        <name evidence="2" type="ORF">LdCL_050006600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858204.1">
        <property type="nucleotide sequence ID" value="XM_003858156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8A7"/>
    <dbReference type="GeneID" id="13391045"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0210"/>
    <dbReference type="OMA" id="AGHYEAN"/>
    <dbReference type="OrthoDB" id="273905at2759"/>
    <dbReference type="PhylomeDB" id="E9B8A7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="759" mass="80380" checksum="43A4A07B82D02428" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8E6</accession>
    <accession>A0A3S5H5I5</accession>
    <name>E9B8E6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_050560</name>
        <name evidence="3" type="ORF">LdCL_050010700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858243.1">
        <property type="nucleotide sequence ID" value="XM_003858195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8E6"/>
    <dbReference type="GeneID" id="13391611"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0640"/>
    <dbReference type="OMA" id="PAYQERF"/>
    <dbReference type="OrthoDB" id="264396at2759"/>
    <dbReference type="PhylomeDB" id="E9B8E6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="419" mass="44417" checksum="979ED390ED236865" modified="2011-04-05" version="1">MVLIASCNALYFPREPRDNVLKVRWNAQDAPLEPNTSVIFKVKCTAPHLFHALPRYGALLLADATGAATPSSNQTTTITFSLRESHGGGAGEISPTGVSRQTAPTTTRTSRASSATPGGPAYQERFAIEYVMIKSEPLAFQQISNSVADAAQLTEVVKNMWSLVASGAIPRAHLGVQAGINLKVYMENVVLQPSDPAPSGGNEATKVVVPPEACLVLPTASERQGRSVHDVTHPGRSRPALDPSPRVYNGGDGADHLGSTSSVFRRKPADELRALREEINTMRRESATPRSAAGGSVRNSSSPSSNTPNSKPRGHEGAAAMQPLPAHRAAGASSYEDLIMKFDLGGAASRAGAPAAQKKEGLKVYMVLLLMSALYVCLLFMRRGATHAEGVKNGSGNGADAAEQRYAVQLSSREVQMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAZ5</accession>
    <accession>A0A3S7WRV0</accession>
    <name>E9BAZ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_120180</name>
        <name evidence="3" type="ORF">LdCL_120007100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859132.1">
        <property type="nucleotide sequence ID" value="XM_003859084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAZ5"/>
    <dbReference type="GeneID" id="13390147"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0290"/>
    <dbReference type="OMA" id="ECITMSS"/>
    <dbReference type="OrthoDB" id="266719at2759"/>
    <dbReference type="PhylomeDB" id="E9BAZ5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="970"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1095" mass="113777" checksum="4904FED19E6F014F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCX8</accession>
    <accession>A0A3S5H6Y5</accession>
    <name>E9BCX8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_161240</name>
        <name evidence="4" type="ORF">LdCL_160017600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859811.1">
        <property type="nucleotide sequence ID" value="XM_003859763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13393205"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1510"/>
    <dbReference type="OMA" id="AVMANQM"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="PhylomeDB" id="E9BCX8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF144">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="920"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="3">
        <location>
            <begin position="721"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1440" mass="157773" checksum="646D657AD92FEE95" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDM5</accession>
    <accession>A0A3S7WUU8</accession>
    <name>E9BDM5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidic acid phosphatase, putative</fullName>
            <ecNumber evidence="9">3.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_180440</name>
        <name evidence="9" type="ORF">LdCL_180009300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="9"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860058.1">
        <property type="nucleotide sequence ID" value="XM_003860010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDM5"/>
    <dbReference type="GeneID" id="13393411"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0540"/>
    <dbReference type="OMA" id="VSLWRIF"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="PhylomeDB" id="E9BDM5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000037">
        <property type="entry name" value="Phosphatidic acid phosphatase protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="249"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="417" mass="45384" checksum="4E300FF691E536B9" modified="2011-04-05" version="1">MASCTVVALWRFIIFFRLHDYVLCLICGLVALGMSKVHPHCRPFSWTDPSINFPYAGAGTFPSWTLPIISILPVVVYILGEAARHLWLGRRRGAIMAREPCNQQKWLTMQGQRDGGGGAAQNAGEGQSCCDSTSPLTFPSQSVQSALPAGRQGEIEVLVNSAPLSANVETREAQVGSSTVTTALSNCQPGSLRTPLANTHDEHTGNRESTSVADASPSRATASAPRKQKAHTYALAHPWQRFLFHAHIWFLTQAFSVAFALLVVNAIKVYAGRLRPDFLSRLRNEGYSPQSTGIDLCTVPKDGRVSFPSGHSSISFSAIAPFCFYVLHSLQAFRRSGVSLWRIFMGLLPLTLPIVVAVSRTRDNRHYFDDILAGSAIGIVSAVIAVSAIMVADARTGHLVPRILYRPCSSARMHTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE39</accession>
    <accession>A0A3Q8IA70</accession>
    <name>E9BE39_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleosome assembly protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_190440</name>
        <name evidence="4" type="ORF">LdCL_190009400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860222.1">
        <property type="nucleotide sequence ID" value="XM_003860174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BE39"/>
    <dbReference type="GeneID" id="13386034"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0490"/>
    <dbReference type="OMA" id="VSPITWK"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="PhylomeDB" id="E9BE39"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000010">
        <property type="entry name" value="Probable nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="350" mass="39818" checksum="9BC29E4835526CD2" modified="2011-04-05" version="1">MPPKNQRNAPVVIPEEDDEGDMMEMDNMLDFQKYLDSDFSKNFMAGLPEKIRQRAQVLSAYDKDFSAQQKAYKVKEMDILRRYDALFEPLLQRRKEIVTGAAVSDEEVKKGMPEEHVNVISVEVDDTDEAAKAADAFGLEGFWLRVLRHHTVIDSTIEPHDEDVLKHLVDIRSSVAEGEYGSFQVIFTFSPNDFFEEETITATVSIKDDKPELTVSPITWKPGKNVMMHTVTKKQRAKRTGQVRTTTRDVPQLSFFWLFKKKTEAVGDDDGEEDGEEDDEEQRISMLEVLHTCIVPNAVRYYTGEAPNGFSDVDEEDEEDEEEEEEEEEIIPRGRGGNRGGRGGRGGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGC4</accession>
    <accession>A0A3Q8ICJ5</accession>
    <name>E9BGC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, zinc-containing-like protein</fullName>
            <ecNumber evidence="4">1.6.5.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Quinone oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_231050</name>
        <name evidence="4" type="ORF">LdCL_230017300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.5" evidence="4"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861004.1">
        <property type="nucleotide sequence ID" value="XM_003860956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGC4"/>
    <dbReference type="GeneID" id="13390203"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1410"/>
    <dbReference type="OMA" id="HKHMEDA"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="PhylomeDB" id="E9BGC4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36644" checksum="665F9BB121E1489E" modified="2011-04-05" version="1">MMRAVTLKGLGGIATMSISEVPKAAVKKGTDVLIKVMAAGVNRAGVSQRRDNYAPPDGANELLGLEVAGIVEQVGSDVAGRVKEGDRVMALLPGGGYADYAVAHMGCVMAMPQGYTFTEAAAIPETFIRAWQILHRHGKVKRGQKVLIHAGASDIGSASAQITEKYFKATAITTSSEEKLDVCKAHASVTLSRTPDELGLAFAPKLKRLFGEESVNVIVDPVFGGTYLSENAQVLAPNGHLIVIAFMGGALVHMNALPLFRERAKITFSKLHCRSDQYKADLVTSFEREIVPYMSERIICTIVDRTFPLEEVTNAYKFLAENHGHGKVVLTVCEPSKLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLV3</accession>
    <accession>A0A3S7X3G7</accession>
    <name>E9BLV3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol dehydrogenase 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alcohol dehydrogenase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_302100</name>
        <name evidence="8" type="ORF">LdCL_300026400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862922.1">
        <property type="nucleotide sequence ID" value="XM_003862874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLV3"/>
    <dbReference type="GeneID" id="13385630"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300026400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2860"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="PhylomeDB" id="E9BLV3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08189">
        <property type="entry name" value="Fe-ADH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000001">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="6">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="201"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="399" mass="43362" checksum="E7687145FBA77729" modified="2011-04-05" version="1">MACRSYQFTICATSYLLRWRAPAVTQGSGALATLPHLVRGARLKRGLLVTDAMIMKLGLVDDFIDEMKKQGAELAIYKDVLPNPTIDMVEEASALYKKNKCDCLVAVGGGSVMDCAKLIGVRQARPRTPLPYMRGLLRVLWPLPPLIAVPTTAGTGSECTIAAVVSDPAKKDKLVVMDPFLTPSHCVLDPALTMTLPKFVTATTGMDALTHVVEAYTNVFHYRTVDKAALRAMELLAKYLPCAYKDGSNLEAREKMLQASYLAGLSFTRAGVGNVHAAAHAVGGLYNVPHGYANAVILPHVLDMYGSAAHKSLARLAEAANIVGGNDAEKAANFISWVREMNAQMQIPTTLGASDSRWVPQEEDIPFLVKHAVIEANPFYAVPVIFGEEEMTELFRRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNF3</accession>
    <accession>A0A3S7X5A4</accession>
    <name>E9BNF3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rtf2 RING-finger containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_320490</name>
        <name evidence="1" type="ORF">LdCL_320010400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863467.1">
        <property type="nucleotide sequence ID" value="XM_003863419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNF3"/>
    <dbReference type="GeneID" id="13390279"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0620"/>
    <dbReference type="OMA" id="NVERWRH"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="PhylomeDB" id="E9BNF3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22965" checksum="2FC41C64247D33D9" modified="2011-04-05" version="1">MGGDGQALANKRSLLQKSRVYVTAIDLESGQAKEKTSQKSRTVERWSHCALSLQPLEAPVVFDGAGDIFSKQSVINYLFDRKERSYGAVGDKEDKFCIKKLADVKEIANEVGSDGSVCCPITDYSTVSGVHSFVGFWGCGHVVSASTLNKSNDLKSQIDVECPFCGLESFYVRLICEDAEDAENQQMFLRHYIKRFRKRVRDDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQW2</accession>
    <accession>A0A3S7X7T0</accession>
    <name>E9BQW2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_341610</name>
        <name evidence="2" type="ORF">LdCL_340022400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864323.1">
        <property type="nucleotide sequence ID" value="XM_003864275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQW2"/>
    <dbReference type="GeneID" id="13392732"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2450"/>
    <dbReference type="OMA" id="HNLHGFT"/>
    <dbReference type="OrthoDB" id="271998at2759"/>
    <dbReference type="PhylomeDB" id="E9BQW2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="509" mass="55213" checksum="988158496FFA04C0" modified="2011-04-05" version="1">MSVDAMTPSFEGTAIKVYHEPPQQLALSNHNLHGFTRRVETGDVPLRLDVIPDDAYVDYGTNLPKLNTEKEEVGDHREASVLTAAGRTRDPGDLSSEVADSVTQYSNASLHGGETSIEGNGWNIEDASVDPQVGSPTRHHTDPLSSANLNQHLHELSRGPAPLRVENIAASGVPYLQRQRNASTTTVLPETTAASLMVESSEVDAMSTSEVASLSRIRPAKLTSVGDTMDDMWSTTSTRGFDTMYLGTGGTKDETLHALSKENLRQLRHQLESGETPLRPEVLAGLSTMVQAMTQTKSAKSASTAVEPAMTEGRSKLVDSAACLGSSLQSFADARGPFLLASANLTKDGDASAAAGMSFRRTLMDMPAREACDGRAHDSSDYPNEEFLRSPHVDVSDRDVDEEGAVDEVEAENADEEEDPLHVKTSTSDDSCEGQNESVFNMTEDDGVDDMSDPAAMSRHMRELFKLVQEGRQDQSHLLQLVLEQRSVIQYLQSTVKDLEAELSALKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRR0</accession>
    <accession>A0A3S7X8R6</accession>
    <name>E9BRR0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_350280</name>
        <name evidence="1" type="ORF">LdCL_350007800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864621.1">
        <property type="nucleotide sequence ID" value="XM_003864573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRR0"/>
    <dbReference type="GeneID" id="13387499"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0370"/>
    <dbReference type="OMA" id="KVFQHAV"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="PhylomeDB" id="E9BRR0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14972" checksum="0C63BEF8DAEF1B33" modified="2011-04-05" version="1">MKDKTELSALLQGFANTSDYNERLVVPHFAYTEGGASYYKGAAAFKRLIRMNVPLPVICLAARSDPITGESRTKAQRQALIDEHPNVVHVETPASGHLSCLPGPLNEVRGRGEFFIYFTLKVFQHAVRVLKETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BU26</accession>
    <accession>A0A3S7XB24</accession>
    <name>E9BU26_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exosome complex exonuclease RRP41A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Exosome complex exonuclease rrp41, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_363170</name>
        <name evidence="4" type="ORF">LdCL_360038200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865432.1">
        <property type="nucleotide sequence ID" value="XM_003865384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BU26"/>
    <dbReference type="GeneID" id="13388318"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360038200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4370"/>
    <dbReference type="OMA" id="ECRINTH"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="PhylomeDB" id="E9BU26"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000047">
        <property type="entry name" value="Exosome complex exonuclease RRP41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="155"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26873" checksum="B40F45BBA9F721D1" modified="2011-04-05" version="1">MSRQKEYVSPAGLRLDGRRPLEARRMDIAFGTLSACDGSCDITLGQSKVCACVFGPRESLHKQEAKHDKGLVTCEVAVAAFAGENRRNPQRRSKLSEDIGAAVVQVARSVILLSQYPNSQIHIYIEVLQKDGNEKIACVNAACLALIDANVAMRDAVCCIDAGILDEHMLIDLTNDELRSQCPVIAAAFTGHDTRNIIWLETASRLPPDSAARLLKCAEEGATKLFETAMRKALEEHAKKILTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8K6</accession>
    <name>A0A3Q8I8K6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8K6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0990"/>
    <dbReference type="OrthoDB" id="264882at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1247" mass="132886" checksum="07147BB0BDD2F066" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9H5</accession>
    <accession>E9BBE3</accession>
    <name>A0A3Q8I9H5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_33280</name>
        <name evidence="3" type="ORF">LDBPK_130690</name>
        <name evidence="2" type="ORF">LdCL_130012300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859280.1">
        <property type="nucleotide sequence ID" value="XM_003859232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9H5"/>
    <dbReference type="GeneID" id="13390470"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0880"/>
    <dbReference type="OMA" id="WTARPWA"/>
    <dbReference type="OrthoDB" id="267887at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="223" mass="23464" checksum="7E5022721D2A9701" modified="2019-04-10" version="1">MLRRTGCCLALFSSAGGSAPRSKRPHSSSGTDASASEEAAAAAGVYLPWTARPWAVTYRVHYSQWKFVDTVFAHLATVTPAVLNDRAEEQGVRDVLCELEEPVVALRRQQARQARQLKKQEKPSAASATSSPSQLLDSALQCTATTAQASPSGTAPSDMTADGAATAEAACALEPLANRADVAATQEAVDSNITLLDASKKGSRKSKRASRKSATSAVVIYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB38</accession>
    <name>A0A3Q8IB38_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_180012000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB38"/>
    <dbReference type="SMR" id="A0A3Q8IB38"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0900"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06103">
        <property type="entry name" value="ScCS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="470" mass="52294" checksum="7FB8037D3E2945AD" modified="2019-04-10" version="1">MRALRCSIIRGVAGLRMASSVLDEMKEQMLRRCREDQKKIDDLRKKHGHEKLCDATIDAVYGGMRGITGLVYEPSLLDSAEGIRFRGLTILECQEMLPKAPGGKEPLPEAMFWLLMTGEVPTEEQARGLNAELHRRVDPEAIAAAQKAIAALPKNAHPMTAFSVGVLALQTYSKFAAAYAAGKSNKKTYWEYALEDSLDMLARTPAVAAMIYNRETKGQVELAAPSNSDLDWAANFAKMLGFHDEEFRECMRLYLSVHADHEGGNVSAHTTTLVASALSDPYLAFSAGLNGLAGPLHGLANQEVLKYLFSMQERVKADGVNVHDEAALEKALTKYTWELLNSGQVVPGYGHAVLRKVDPRYTCQRNFCLRHNFQDDLFKLVNTIYMIMPGILKEHGKTKNPYPNVDAHSGVLLQHYGLTEQNYYTVLFGLSRQMGVLAGVVWDRLQGRPLERPKSITTEMLAKKYLCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBD4</accession>
    <accession>E9BG28</accession>
    <name>A0A3Q8IBD4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase-like protein</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Arginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_17655</name>
        <name evidence="5" type="ORF">LDBPK_230080</name>
        <name evidence="4" type="ORF">LdCL_230005700</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860909.1">
        <property type="nucleotide sequence ID" value="XM_003860861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBD4"/>
    <dbReference type="SMR" id="A0A3Q8IBD4"/>
    <dbReference type="GeneID" id="13389633"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0100"/>
    <dbReference type="OMA" id="IQAIYAK"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000017">
        <property type="entry name" value="Agmatinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="332" mass="36554" checksum="8AEB6A65CC9FF138" modified="2019-04-10" version="1">MFTKFLSRVKALPPRSGDWANKLGPVALMGCSGGAHMSSTKLLNHFYTSPRDCDMYAELTFHEPGPVECPPETVIFFPVIQCGEMLDDKGEPSEASKDDWYLAMTEATTELLEKGYVPVSVGGDGSATLAMVEAYKRLFRSSEVVLIHCSARPSLEKAEQPIRVLLEKGLLKGVVEIGNRCVSSGDRKIRKQHKVMYMDMQAIYAKGLFCIRDIRNDYPVFLSIDADVLDPAFAPAVESPVPGGLSTRDLLHIMTGIRGPKVAGIDIHGYHPSLDMCRSDGVGLTQMALTKVLKESIVKAYTISTQTAEEGLERVRLMQRQGTLSDNPYPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBF1</accession>
    <name>A0A3Q8IBF1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SpoU rRNA Methylase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_240022900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBF1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2140"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000053">
        <property type="entry name" value="SpoU rRNA Methylase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF14">
        <property type="entry name" value="TRNA_RRNA METHYLTRANSFERASE SPOU TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="284"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="519" mass="55138" checksum="B426E5BF6F2BA4CB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBJ0</accession>
    <accession>E9BH95</accession>
    <name>A0A3Q8IBJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fatty acid desaturase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Fatty-acid desaturase, putative</fullName>
            <ecNumber evidence="14">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC21_16740</name>
        <name evidence="15" type="ORF">LDBPK_242340</name>
        <name evidence="14" type="ORF">LdCL_240029000</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="14"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861322.1">
        <property type="nucleotide sequence ID" value="XM_003861274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBJ0"/>
    <dbReference type="SMR" id="A0A3Q8IBJ0"/>
    <dbReference type="GeneID" id="13391482"/>
    <dbReference type="KEGG" id="ldo:LDBPK_242340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2900"/>
    <dbReference type="OMA" id="WNDWRGG"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="380"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU79319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP52353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="431" mass="49013" checksum="82F43E5404863859" modified="2019-04-10" version="1">MTSVEKKGKDMTEETTRRQPTYQEGNYEINYVAVAVLGLPIAGVLAAVFMGVPLQWKTFVTAVVFYMFNGCLGVTVGYHRLFSHRSYTASTAFQWLCAFAGAGSFEGSAKWWGRNHRIHHRYVDTEKDPYNAQRGFIFSHMGWMIMKQDYSLLGKVDVSDFKYNYVIQFQHKHFFKMAMLSGVILPTVICGLGWGDWLGGYFYAALAKIVFVHHCTFFINSLAHTNLFAAVQNYSDRHSSHDSFVCALFTFGEGYHNFHHEFAQDYRNGIKWYHYDPTKWIIRAVSFLGGAKNLVRTPKDVIDANFNKMLLKKSRKAMEQAQTRLDQLDIPISAEWTWEKVQDEVAKGRKLTVINNDVIDLMRSIPTGAGYTHSSKDVIWYSNHPGGQRILDMFVGKDATAAFTGGVYAHSCGAESYLQHLRVAKLKVATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBQ7</accession>
    <accession>E9BG96</accession>
    <name>A0A3Q8IBQ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_18220</name>
        <name evidence="6" type="ORF">CGC21_17330</name>
        <name evidence="5" type="ORF">LDBPK_230770</name>
        <name evidence="3" type="ORF">LdCL_230014200</name>
        <name evidence="4" type="ORF">LDHU3_23.1060</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860977.1">
        <property type="nucleotide sequence ID" value="XM_003860929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBQ7"/>
    <dbReference type="GeneID" id="13389938"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1060"/>
    <dbReference type="OMA" id="SKWWRQR"/>
    <dbReference type="OrthoDB" id="252800at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668">
        <property type="entry name" value="HYPOTHETICAL TRANSMEMBRANE PROTEIN L6586.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39668:SF1">
        <property type="entry name" value="T. BRUCEI SPP.-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP51352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="261" mass="27797" checksum="EDED8C31EA0A8826" modified="2019-04-10" version="1">MGTGTGCLYACAPFTLIVSILLFMLSVMLRNGNWTFAVLAAKHSWDAEAKSRCCRNGGLIYLFTSIVLWVLVVVDSFLIQLKKLPTSASKWWRQRRLPSLRELMRKRRKALETEGVDHATDVIVMTTTPTTAVRTAAAKSPQRSAPSAFALPSAEAASPPTVVMAGDPVAADDSRRNTSSAGSARADAGRTGFVFLCPSSPAMGGASVNAAVNISSAKPLPSAGQAYERFAREEAQDRQPLPVSATTSAATSAQEVDYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBX4</accession>
    <accession>E9B9X9</accession>
    <name>A0A3Q8IBX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_8075</name>
        <name evidence="5" type="ORF">CGC21_36895</name>
        <name evidence="4" type="ORF">LDBPK_090920</name>
        <name evidence="2" type="ORF">LdCL_090014600</name>
        <name evidence="3" type="ORF">LDHU3_09.1070</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858772.1">
        <property type="nucleotide sequence ID" value="XM_003858724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBX4"/>
    <dbReference type="GeneID" id="13392109"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1070"/>
    <dbReference type="OMA" id="PMFTHTS"/>
    <dbReference type="OrthoDB" id="273680at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="523" mass="57734" checksum="684ACFEB4BD37B8B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC74</accession>
    <accession>E9BIE8</accession>
    <name>A0A3Q8IC74_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_5165</name>
        <name evidence="8" type="ORF">CGC21_32015</name>
        <name evidence="7" type="ORF">LDBPK_261360</name>
        <name evidence="5" type="ORF">LdCL_260019200</name>
        <name evidence="6" type="ORF">LDHU3_26.1670</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP52016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861723.1">
        <property type="nucleotide sequence ID" value="XM_003861675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC74"/>
    <dbReference type="SMR" id="A0A3Q8IC74"/>
    <dbReference type="GeneID" id="13388969"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1670"/>
    <dbReference type="OMA" id="YNYDVHQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000014">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5430973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP41172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP52016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="194" mass="22190" checksum="2DD24943ECC0032C" modified="2019-04-10" version="1">MNAILEKYTFKDDYVSPRGIPKVAFVENVAELVKSSGDSAETLLKRFSEQYSKYKLAEHRLIRTTANLEAKIPDIKKTLQTLEYLKKSLVAENGGKGFTTNYGLTESVFCQAKVLPQKTVHLWLGANVMVEYTFEEATQLLERNLKSATENLAATQEDLAWLQEQQTILEVNTSRLYNYDVVERRKKSEEEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICL8</accession>
    <name>A0A3Q8ICL8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_250025800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICL8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2470"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="494" mass="53726" checksum="D449C31F643D3D8F" modified="2019-04-10" version="1">MQSASSRVPRKPAAASSLGKPSSSGRCGKPNRPQPTSSFSKTAQPGTAGRFGTSTALVASAAASHFTAGARGQSTPFVGQADRTGREGSVCGLRAPQNGATGAAAHTEKRQAARTKVVDDASAPVVVVGPERDSVPFRLCCEALAEGCVQTYMHLFELAHRDPVCVDTLSRKFFNVPDDRLAWVQQQLSAVEVLRRQSEFEQVFTHCEQLANYFESEGDYAEAAWYHEMALHYMMESLDRTLEQRARHVYATFQERQGHLEEAAALYDAMYRLAVALRDEAALQDASRCLVRVHQALGEALKSSDPAAAARHYATAAEAAVRGKNVVDEGAAYSALGDVSEARGDLPLALKYQRSCRAVAQQNDLKPQECQATLRVADLEERLGLKLEASTTLHEALQLAKELGVPRQLCIATMQLGEAYRSRNQEDEALQCFDESFAAAIEAGDQELIDTVRIAMGFARGDYYLTHAYGGKGYLHLVYTDIRAQLAWMSGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICM3</accession>
    <name>A0A3Q8ICM3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">XPG N-terminal domain/XPG I-region, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_230022500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICM3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2050"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000124">
        <property type="entry name" value="Exonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="8">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="854"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="972"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109119" checksum="E0BE0F5E71D1B9E2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICV6</accession>
    <name>A0A3Q8ICV6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_130012600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICV6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0920"/>
    <dbReference type="OrthoDB" id="273240at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1235" mass="133062" checksum="E3649DA20867EDBC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICX4</accession>
    <name>A0A3Q8ICX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase-like superfamily/Thioesterase superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260025000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICX4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2540"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="335" mass="37234" checksum="74FE51596FE0D562" modified="2019-04-10" version="1">MALAHILRCQRFFWLGLRDRMRVSKMISGTLPIPASDAMMSVVPVKAIRAVAAAPPQTPRPPLPWLVLPWRRQLPPDPAFSQFVAQPMVVPMYCGLRLIDEFGHVNNAKYLELCELARWRQLSFLGIGTMMARLRVAFVVSDLSVTYQREIRPWSRVWLSTRILLPPSSTAFAGPLSSPSSDKRRLYIEHEIWSKDGRKLHAAITLAAALIGPVKYEQELARRYDPTAAAAAAAPPHAPAGTRARQRTTLNCEHVLADALDLSSVAELRKLFESAEHICTPAVGDGDAAATAKSDEMPDQESAARQERITGLARIWRTTRNQLRHTSFISSPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID48</accession>
    <name>A0A3Q8ID48_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280020400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID48"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2020"/>
    <dbReference type="OrthoDB" id="273549at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="744" mass="78384" checksum="7C369A04F80D986E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDA6</accession>
    <name>A0A3Q8IDA6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LdCL_250015400</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">LdCL</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1280"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000018">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000017">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001386">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000014">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000020">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002148">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1959"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2589"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1649"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="3219"/>
            <end position="3286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="3462"/>
            <end position="3524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="3762"/>
            <end position="3803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU79433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4702" mass="536895" checksum="AE544337F1BAC140" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDN8</accession>
    <accession>E9BER5</accession>
    <name>A0A3Q8IDN8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_31515</name>
        <name evidence="15" type="ORF">CGC21_29265</name>
        <name evidence="13" type="ORF">LDBPK_201160</name>
        <name evidence="11" type="ORF">LdCL_200016300</name>
        <name evidence="12" type="ORF">LDHU3_20.1430</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860457.1">
        <property type="nucleotide sequence ID" value="XM_003860409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDN8"/>
    <dbReference type="GeneID" id="13386243"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1430"/>
    <dbReference type="OMA" id="GWFFQVM"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5429673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP49887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="319" mass="33991" checksum="10778E75AAE7A4A0" modified="2019-04-10" version="1">MQTPHTPTINFGPTGGSGSPGGGTAFFGRSDPNAMMLQMGLSYGQNILQKHVQQGEAGLAYYMPVIRAIRNYFAVDNTYVKRKLIILTMPFFTKYVRKSPAGGESDFGSSGGVGEATGDQVFGGPAGSPASMFPAVSPSTLAGHDGGGNTFAGPSLPLNDVFASDLYIPLMSVITYVVLAAYILGANSPTSSVTAASLISTAWVIGIWFFLEVVVLKGVAYALLVVPNPPLLELLALCGYKYVLLCLGVLASQCLPPSRLYSGLFMLYAVLAHSFFTVRVLGLQYMRNDGRVLPRSRVFTYMAALAQVPGCVWLFVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDZ1</accession>
    <name>A0A3Q8IDZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280022700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2320"/>
    <dbReference type="OrthoDB" id="265315at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1373" mass="143785" checksum="FB061FADE785DAEC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE12</accession>
    <accession>E9BLB7</accession>
    <name>A0A3Q8IE12_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_34930</name>
        <name evidence="8" type="ORF">LDBPK_300220</name>
        <name evidence="7" type="ORF">LdCL_300007300</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862737.1">
        <property type="nucleotide sequence ID" value="XM_003862689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE12"/>
    <dbReference type="SMR" id="A0A3Q8IE12"/>
    <dbReference type="GeneID" id="13385444"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0350"/>
    <dbReference type="OMA" id="KECAGFT"/>
    <dbReference type="OrthoDB" id="262731at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP45595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="386" mass="42451" checksum="98A16EA0491B9B7F" modified="2019-04-10" version="1">MNYLRTVVADVKLKYRASRVVAECVLRREQPEFPQFLTECVTIADGHPELILSTIRLYLEYNQPERAHGGLLLLEQLVSLCNYAFHLALARDYDIQDRIIHLAMKRGEGEAHQKTQRLARLTLLEYSRLFVDDRDLLRLSALVSSFEHRTHKSLMRCLNVQNRRVRFRDVEKSDIIPISPKECVGFTSSSAGRPVKPLQLSSAPEVWPCRVCAYLNAPSAMRCAACETLHTTDMATHRSSPHTTPKMSPASSTSVATANGTNVGRRSPIVPPLPMAVEGEMETGDSQASSGANMEDMDATFPISDWDNTSGGHLHPCHVPPTAVYADPAHLPHIATSTAVSTSTSDISAHISPSTASEPGDVASEAYYDRIEGSIANGVAPHELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE82</accession>
    <name>A0A3Q8IE82_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_290006700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE82"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0260"/>
    <dbReference type="OrthoDB" id="272959at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="536" mass="57109" checksum="61CC371DBD19D0A7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE93</accession>
    <name>A0A3Q8IE93_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar-associated PapD-like/Zeta toxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300023400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2520"/>
    <dbReference type="OrthoDB" id="442692at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031549">
        <property type="entry name" value="ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053:SF0">
        <property type="entry name" value="HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="612"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="683"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Abnormal spindle-like microcephaly-associated protein ASH" evidence="7">
        <location>
            <begin position="4359"/>
            <end position="4439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2080"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2857"/>
            <end position="2893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3484"/>
            <end position="3521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3614"/>
            <end position="3683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="4091"/>
            <end position="4113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="5112"/>
            <end position="5154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2082"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2109"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2878"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="3484"/>
            <end position="3506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="3510"/>
            <end position="3521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="5123"/>
            <end position="5137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="5559" mass="590196" checksum="53527927925EBCB3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF68</accession>
    <name>A0A3Q8IF68_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290021300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF68"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2280"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000678">
        <property type="entry name" value="Ankyrin repeats (3 copies), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="712" mass="75394" checksum="384253907E87181F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFH0</accession>
    <name>A0A3Q8IFH0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SpoU rRNA Methylase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320023400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFH0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2270"/>
    <dbReference type="OrthoDB" id="239614at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="71488" checksum="0F280A883A0C5515" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG61</accession>
    <name>A0A3Q8IG61_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_4135</name>
        <name evidence="1" type="ORF">LdCL_310006200</name>
        <name evidence="2" type="ORF">LDHU3_31.0160</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG61"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0160"/>
    <dbReference type="OrthoDB" id="277508at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="127" mass="14770" checksum="6EFA22B44EC0571F" modified="2019-04-10" version="1">MLRCLGLLLAKPQAAPRRSTIHATSSCKKGKDRFDLFHALQKDRQRIRHNRTLPWRQRLDQLRVYPWKLFLAFMMFWSWLGTYAVPYLKGMSAGELPSVGQGRLIPAEVRAKATPTPQFAHLKERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGF4</accession>
    <name>A0A3Q8IGF4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypanothione synthetase, putative</fullName>
            <ecNumber evidence="8">6.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_270024900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGF4"/>
    <dbReference type="SMR" id="A0A3Q8IGF4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2730"/>
    <dbReference type="OrthoDB" id="64566at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047479">
        <property type="term" value="F:trypanothione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.330:FF:000001">
        <property type="entry name" value="Bifunctional glutathionylspermidine synthetase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1720.10:FF:000011">
        <property type="entry name" value="Trypanothione synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF17">
        <property type="entry name" value="SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="7">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="652" mass="74197" checksum="84286C45DB48431B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGX1</accession>
    <accession>E9BV54</accession>
    <name>A0A3Q8IGX1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cytochrome b5-like Heme/Steroid binding domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_18750</name>
        <name evidence="8" type="ORF">CGC21_38715</name>
        <name evidence="6" type="ORF">LDBPK_366980</name>
        <name evidence="4" type="ORF">LdCL_360082400</name>
        <name evidence="5" type="ORF">LDHU3_36.9320</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865809.1">
        <property type="nucleotide sequence ID" value="XM_003865761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGX1"/>
    <dbReference type="SMR" id="A0A3Q8IGX1"/>
    <dbReference type="GeneID" id="13386663"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360082400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9320"/>
    <dbReference type="OMA" id="DQWHAFF"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5435287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ39133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP53359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="146" mass="16211" checksum="C9B3CE6A0667B170" modified="2019-04-10" version="1">MSWWNFWSRSSDSKEEATSDNGNRAAKTAGPAEMRSFTAAELAQFTGENGTPIYMSVKGKVYDCTCGAAFYGPGNSYAVFAGKEVSRCLGKMLISDEEANANWDDLTPEHMQSLDEWAAKFDSKYPVIGIFVPDEEYYARQKTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHZ5</accession>
    <name>A0A3Q8IHZ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND finger containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_330032600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHZ5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330032600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3640"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="713" mass="76216" checksum="A81244DF2067274B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIK1</accession>
    <accession>E9BRI7</accession>
    <name>A0A3Q8IIK1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_343890</name>
        <name evidence="9" type="ORF">LdCL_340048300</name>
        <name evidence="10" type="ORF">LDHU3_34.6190</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864548.1">
        <property type="nucleotide sequence ID" value="XM_003864500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIK1"/>
    <dbReference type="GeneID" id="13387427"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340048300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6190"/>
    <dbReference type="OMA" id="RVAFDME"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000247">
        <property type="entry name" value="Ubiquitin hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5433986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ37866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="906" mass="102628" checksum="D6896E4652E766A3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIP3</accession>
    <accession>E9BTA6</accession>
    <name>A0A3Q8IIP3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_12565</name>
        <name evidence="4" type="ORF">LDBPK_360470</name>
        <name evidence="3" type="ORF">LdCL_360009600</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865163.1">
        <property type="nucleotide sequence ID" value="XM_003865115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIP3"/>
    <dbReference type="GeneID" id="13388049"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0620"/>
    <dbReference type="OMA" id="RIVHSCL"/>
    <dbReference type="OrthoDB" id="275750at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23735">
        <property type="entry name" value="RESC6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599606" description="RNA-editing substrate-binding complex 6 protein domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="103"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="482" mass="52569" checksum="A25774A3367352AE" modified="2019-04-10" version="1">MRRRLACWPIAAFAVARAITTNSFVSSIEQVQQQLQTAQDRRVELLRYGRQLYEVEVLDDLKTAYTPAVASKICYVASQLRIDATKGQPYTAVLEATMTAEGEQAMDVASLARIVHSCLVLRSGHLHEVLFTFIPFLREKAGTMDAVTTAVLINAYGRSGVHHPGLYKALCDNGATVLKDPRVPLAHIANVAYAVSRVKFLHPALMLTLRDHALRKVAEASPIISLTVLDAFTELRQIDDDLFSAYEQRLLGQLNELQAPLMASLVSCVVRAGRGKAEVMESLGARTVAIADTFDAASIAKVTNAYYEADVASEDVLGALAERACKVAADFRADEIATVLNALSAFDLFDAELFPLLASRLVALHRQGGYVDVADAAVILSSFAAVQERNDELIYVCTQLFAAYPGVAMDPAVRVNALWACASLNVHNEAQTKMLEEVRATPSLVMWESKTDMLPKAKAMLEERTQFLAKVYGITISSSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJD4</accession>
    <accession>E9BLQ9</accession>
    <name>A0A3Q8IJD4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_35600</name>
        <name evidence="12" type="ORF">CGC21_35625</name>
        <name evidence="10" type="ORF">LDBPK_301660</name>
        <name evidence="9" type="ORF">LdCL_300021900</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862878.1">
        <property type="nucleotide sequence ID" value="XM_003862830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJD4"/>
    <dbReference type="GeneID" id="13385586"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2250"/>
    <dbReference type="OMA" id="FMMWMVG"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP45734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="150" mass="17005" checksum="07E5849A347F0715" modified="2019-04-10" version="1">MASAVADVNASAKQMTDKEITRHRVMARLSEIRTQPLKQLPMTVFMMWMVGNEVSIFSIMFVGMAVVNPLQSILSAGKLFADFEEDTKTDRQIRSAVNQARWIYIGCCLIAFLVALVKLNWMELLPVSSMDWMDNTPPTYQELSSGAFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJX2</accession>
    <accession>E9BE29</accession>
    <name>A0A3Q8IJX2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Intraflagellar transport protein 80, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Intraflagellar_transport_protein_80_putative/Gene DB:LmjF.19.0330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_190330</name>
        <name evidence="7" type="ORF">LdCL_190008300</name>
        <name evidence="8" type="ORF">LDHU3_19.0380</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860212.1">
        <property type="nucleotide sequence ID" value="XM_003860164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJX2"/>
    <dbReference type="SMR" id="A0A3Q8IJX2"/>
    <dbReference type="GeneID" id="13386024"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0380"/>
    <dbReference type="OMA" id="WDAQGAN"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000007">
        <property type="entry name" value="Intraflagellar transport 80 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056456">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24098:SF0">
        <property type="entry name" value="OUTER SEGMENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23335">
        <property type="entry name" value="Beta-prop_IFT80_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80 second beta-propeller" evidence="5">
        <location>
            <begin position="123"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="6">
        <location>
            <begin position="440"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="594" mass="66502" checksum="AD599F440C81A2AE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK39</accession>
    <accession>E9BT81</accession>
    <name>A0A3Q8IK39_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial inner membrane signal peptidase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Peptidase S24-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_12445</name>
        <name evidence="9" type="ORF">LDBPK_360220</name>
        <name evidence="8" type="ORF">LdCL_360007200</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865139.1">
        <property type="nucleotide sequence ID" value="XM_003865091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK39"/>
    <dbReference type="GeneID" id="13388024"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0320"/>
    <dbReference type="OMA" id="CDVSCAV"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="7">
        <location>
            <begin position="33"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP48139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="225" mass="25594" checksum="60236C47F05DEB06" modified="2019-04-10" version="1">MRWRQWWSALRYSKYGDVPFVLLGVLIGWNCDVSCAVKGVSMVPTLNPGEYILFVPYTMLQVRRWFNAPLVNLSDVVVVKVSDDLSVCKRVVKCTSSRAQAEEWGKEHYVEVMPAPYSPPVPQHMNGDDEDSTEVDSATNSERAYFDYVARNTVRSKDWDSCIDRIPNPSQWIWLEGDNKSESFDSRRCGPVPVECIRGLVLASIWPSPHALQRPPPPPRASQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKS7</accession>
    <name>A0A3Q8IKS7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360052000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360052000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6090"/>
    <dbReference type="OrthoDB" id="272567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1686" mass="178588" checksum="BA03211719F21DB9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL58</accession>
    <name>A0A3Q8IL58_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp1 P-loop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360046000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL58"/>
    <dbReference type="SMR" id="A0A3Q8IL58"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360046000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5240"/>
    <dbReference type="OrthoDB" id="275196at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002747">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF17">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 P-LOOP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="3">
        <location>
            <begin position="110"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="452" mass="49496" checksum="0FB454091D40BF3A" modified="2019-04-10" version="1">MPPKKRSSRRLTLNAGEEYTLIGDGAVQITLQSGLLDVAGVMLDANRPYTFYLHTDRQAITLFTLEGAACMLSSDNRVDTHRGVARAGKLVQMTRRTILSAKRTKVLVIGRPRSGKTLAAHTLCNLLMRYGNDKKSVFLMDLNAESNCLFAPGCVSCIQVSESPLWPGLTASPKLLPLSLYTGAAVRPSASNVNSLLHYYDQLHETVMGYIQELSGAAAVAAQQQSPSPYAPSLSETHSHVVVDAPAPLADLQEGVWYKKLIEVLRPSHVVIVSSREDGEERWSTFLQEDVQRVLPDCEFLFTDPVAHPCERSSSRELLREYFTGTPFYSLGCSKVVVPLKSLTFVEEASEGLAPGSADGVLMRVVHPDASFQALVCALSHAELLEEAPLAPIAGLVTIVYVDEKNEEVAMLIPAAEEPLLRRLIIVPQSRYRDTLRMSSAQVATMEEYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMP6</accession>
    <name>A0A3Q8IMP6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240015900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1270"/>
    <dbReference type="OrthoDB" id="273537at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1681"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2139"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2364"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1681"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2149"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2400"/>
            <end position="2409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2519" mass="268058" checksum="21064BC88148896C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IN09</accession>
    <accession>E9BT04</accession>
    <name>A0A3Q8IN09_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane- trafficking protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Membrane-_trafficking_protein_putative/GeneDB:Lmj F.35.4790</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">SCAMP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_14365</name>
        <name evidence="9" type="ORF">CGC21_7840</name>
        <name evidence="8" type="ORF">LDBPK_354850</name>
        <name evidence="6" type="ORF">LdCL_350053500</name>
        <name evidence="7" type="ORF">LDHU3_35.6370</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865062.1">
        <property type="nucleotide sequence ID" value="XM_003865014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IN09"/>
    <dbReference type="SMR" id="A0A3Q8IN09"/>
    <dbReference type="GeneID" id="13387940"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350053500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6370"/>
    <dbReference type="OMA" id="YPTGNQW"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5434506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP47859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="220" mass="24767" checksum="9448A8C3EF6C5CDC" modified="2019-04-10" version="1">MTTITEAMVLEKERQNAARRDALNKRSQNVSRLAEPEPNFPPECCCVKPVIYHNIREQVPVTQQRFMYILAGLYVTLMALIIYNIVAALVAFALGGSALHFGLSFVYLLGLPGAWISWYYNVYCAIVYASRSRQLIALLGLLVGVVFDVWMTIGITGFGGCGWIYALSLTRNVAPFVLVLISAILWPLHGFALCVMLLRYWRLSRVLLKNTANIYRQSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INF1</accession>
    <name>A0A3Q8INF1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360015900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INF1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1420"/>
    <dbReference type="OrthoDB" id="273175at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018669641" evidence="3">
        <location>
            <begin position="24"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="548" mass="60988" checksum="16A3234153271A8C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4T6</accession>
    <accession>E9B781</accession>
    <name>A0A3S5H4T6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_18015</name>
        <name evidence="3" type="ORF">LDBPK_010170</name>
        <name evidence="2" type="ORF">LdCL_010006700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000041">
        <property type="protein sequence ID" value="TPP54561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857830.1">
        <property type="nucleotide sequence ID" value="XM_003857782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4T6"/>
    <dbReference type="GeneID" id="13389724"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0190"/>
    <dbReference type="OMA" id="SEWTVQC"/>
    <dbReference type="OrthoDB" id="265489at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="457" mass="49330" checksum="2B8AE8AF3CD76B0D" modified="2019-04-10" version="1">MGGCCGVASEAGTASYNDTVSSTPFPPPSRRGRWRGSTRSTSKNEKAALKRSGRLESAPSFLGKILPLKDRGDTDSAPTRGTAVDAVPSAAPLKLSDYATLAAPEHDQDLPFKVTPQHGANGSSPDPLLPDLFYISASSSSSLLANCDVDDSAEDGVGARLDGEGQSSLVEVSQPTQSFAGDVHTYSELDLTSEWEPPSFDRLGRRSERLGRNGTDRSRLRQLIVREAEVRASLTVMYVHQHQRFSLNLAKEHFIAVYVRMRQEYESEWTVQCICWIVAVESVMREALAREWWTERAALVRRVGSLRTPPPPPLRPTCDDARLGITAIHALKREDSLPYVSNLYTAADLTSSEEAAEGDPLNLCIPPMRASSLIALFSPPLQQQLSVLGGSRSASAGVSRGLRSASRVSAPHASSFVSSPASALYSPVPTKRVAAAQQAQKGRFVRGRSMAVTEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Q5</accession>
    <accession>E9B8Q7</accession>
    <name>A0A3S5H5Q5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_24330</name>
        <name evidence="3" type="ORF">LDBPK_060470</name>
        <name evidence="2" type="ORF">LdCL_060009800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858353.1">
        <property type="nucleotide sequence ID" value="XM_003858305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Q5"/>
    <dbReference type="GeneID" id="13391657"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0570"/>
    <dbReference type="OMA" id="FWIAQLH"/>
    <dbReference type="OrthoDB" id="266737at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="457" mass="48102" checksum="64D95813C7E886DB" modified="2019-04-10" version="1">MLAHRRYSSVSSSSSGVFSEPSDGGTSSGNDSNSYYSEGSGSYRSVSSVLTSSRSGATTTAATAASSTSAVDSSSTNTFSDVLTTSSARSHSSAPPRRAVARSAASRSEVVGHKTTKGASGVVVANHNNKGVGDTLAQRTVFTFTETTTASSATVDDTDALVSAPQSPMPQAALAPVSNRTADVAREKRYHISEEELVRHPWAPVDCDTTVDARKGGGDRGGLALSVLDTIHTVSMAVPPPPEEAQRRREEGGLTYPSRLTLRFVRSSSPLRHCASAVAQDKDGTGNGGGGATLGADGATATRARKTFICCCFHGCSGKAPCKMKSYTAMRRKRHHPLRSHHVPLVNFCTTREHGIPMEGVQNVLPSVEEAAGYQNLKVDMMGTEELPKQLQKAIQPWGRPASGLRLEKSYAFGHGAGGGQDGAGQSAFMRDGDPQGFWIAQLHRHASVRLEPIGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5S4</accession>
    <name>A0A3S5H5S4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060013000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5S4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0920"/>
    <dbReference type="OrthoDB" id="267874at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1184" mass="123516" checksum="01902E70669D9EE4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H626</accession>
    <name>A0A3S5H626_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger motif, C2HC5-type/ASCH domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_080005600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H626"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0090"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.30:FF:000006">
        <property type="entry name" value="Putative_zinc_finger_motif_-_C2HC5-type /ASCH_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="490"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="629" mass="68676" checksum="3495126E7878F622" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6E6</accession>
    <name>A0A3S5H6E6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_090019700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6E6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1580"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000280">
        <property type="entry name" value="Mitochondrial carrier protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000288">
        <property type="entry name" value="Putative mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="149"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="257"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36133" checksum="7FC543AD45EB8827" modified="2019-04-10" version="1">MAVAGPSWPTPIVPPVDEGEWALLHPMKTSLVALIPGAAQGATTVVLGHPLDTAKVRMQSGGPHTCRSTVGTMWSMATAEGPSSLYRGVAPPLLMEGIKRSVQFALWDWMRAFARDASASRNGADGAARGGAGGAWEAVRDCAHCGLVGIGSNSFVCGAVAGGVGTLIGCPMHVIKIQTQCQTAMGTRNAWTCTRSIYDREGIFGFYRGFRCNVAKDVCFAGMYLGLYAVLREHPVFEPPSASTTAETTTTTRPSRKTNMCAFLSGAVASMATWGLLFPLDTIKTLVQARQAHAVLSVLRQPALLYRGLAASLIKAGPVSGVAMAVYEQTWAFVNKRPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6F5</accession>
    <name>A0A3S5H6F5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_100008300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0430"/>
    <dbReference type="OrthoDB" id="273821at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="903"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1846"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1912"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1984"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2295"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1913"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1929"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1945"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1986"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2295"/>
            <end position="2306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2348" mass="247733" checksum="B932DE98E660750A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6P4</accession>
    <accession>E9BBH5</accession>
    <name>A0A3S5H6P4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_131010</name>
        <name evidence="3" type="ORF">LdCL_130015400</name>
        <name evidence="4" type="ORF">LDHU3_13.1230</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859312.1">
        <property type="nucleotide sequence ID" value="XM_003859264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6P4"/>
    <dbReference type="SMR" id="A0A3S5H6P4"/>
    <dbReference type="GeneID" id="13390502"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1230"/>
    <dbReference type="OMA" id="WKNDNAQ"/>
    <dbReference type="OrthoDB" id="273410at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039986">
        <property type="entry name" value="CFAP210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="515" mass="60092" checksum="DE8C73A2F08256AA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6V2</accession>
    <name>A0A3S5H6V2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150015200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1250"/>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1849"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2048"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2383"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1855"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1865"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2048"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2083"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2383"/>
            <end position="2392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2537" mass="264378" checksum="4602CF6917E0825B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6W6</accession>
    <accession>E9BCL9</accession>
    <name>A0A3S5H6W6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 1A, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Eukaryotic_translation_initiation_factor_1A_putat ive/GeneDB:LmjF.16.0140</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 1A / IF-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_36310</name>
        <name evidence="8" type="ORF">CGC21_25280</name>
        <name evidence="6" type="ORF">LDBPK_160150</name>
        <name evidence="4" type="ORF">LdCL_160006400</name>
        <name evidence="5" type="ORF">LDHU3_16.0170</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859703.1">
        <property type="nucleotide sequence ID" value="XM_003859655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6W6"/>
    <dbReference type="SMR" id="A0A3S5H6W6"/>
    <dbReference type="GeneID" id="13393073"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0170"/>
    <dbReference type="OMA" id="KMEDQEY"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000370">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5428873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="168" mass="18692" checksum="2ED9B9CFA673221E" modified="2019-04-10" version="1">MPKNMGKGGKSFKAGNSKGNMQNQKRDLTYANPDEGEEYAQVKKALGNLRLELQLAGGSTVIGAIRGAMVRKVWIGQGDVVLVAKREFNENDVVDIIHRFTPAEVRLLVKENAIPRDFRSAEERDNNGNTDYIFVNDEDDAQNDDDDQNAIDRNEVIMDDPLAALDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7R8</accession>
    <name>A0A3S5H7R8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320019000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7R8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1690"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="381"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="766" mass="85367" checksum="F2F03629259A3A84" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPL8</accession>
    <name>A0A3S7WPL8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_060014900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPL8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1120"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046349">
        <property type="term" value="P:amino sugar biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000142">
        <property type="entry name" value="Glucosamine-fructose-6-phosphate aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="344"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="519"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="670" mass="73176" checksum="513C00095C11FD14" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQQ1</accession>
    <accession>E9B9X3</accession>
    <name>A0A3S7WQQ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prefoldin subunit family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Prefoldin subunit, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Prefoldin_subunit_putative/Pfam:PF02996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_8100</name>
        <name evidence="5" type="ORF">CGC21_36920</name>
        <name evidence="4" type="ORF">LDBPK_090860</name>
        <name evidence="2" type="ORF">LdCL_090014000</name>
        <name evidence="3" type="ORF">LDHU3_09.1010</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858766.1">
        <property type="nucleotide sequence ID" value="XM_003858718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQQ1"/>
    <dbReference type="GeneID" id="13392103"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1010"/>
    <dbReference type="OMA" id="DAYKPPQ"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000044">
        <property type="entry name" value="Prefoldin subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="214" mass="23280" checksum="43986CB30B9C8ED8" modified="2019-05-08" version="1">MASLAQLSTPLPSEPSAAAPPPTASAPAGALHLERFLESVLKQNLDTVLSQRDELYATVAQCAQLRWLMEDMQALSRYHSFIEASTAAEAAAAVALSASSPLASGAANASPPLMSKRAQADAYKPPRKNKILVDLGNHFYTQGVVKDAGVLFMNMGCGVVLPMSLDEAREFLRKKEAVVRRMIMNKSKEALRIKYRIRLVTEAIARLHERHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR10</accession>
    <name>A0A3S7WR10_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pteridine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_100008900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR10"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0510"/>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="745" mass="80695" checksum="5114791957FCD0BA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRM1</accession>
    <accession>E9BAS0</accession>
    <name>A0A3S7WRM1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_110820</name>
        <name evidence="2" type="ORF">LdCL_110013600</name>
        <name evidence="3" type="ORF">LDHU3_11.1020</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859058.1">
        <property type="nucleotide sequence ID" value="XM_003859010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRM1"/>
    <dbReference type="SMR" id="A0A3S7WRM1"/>
    <dbReference type="GeneID" id="13389536"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1020"/>
    <dbReference type="OMA" id="CKRTEVE"/>
    <dbReference type="OrthoDB" id="273718at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="337" mass="37409" checksum="8FF6949F92D05C5D" modified="2019-05-08" version="1">MEEGVPTPAAPVGEDQEVAAAPATEEPAPIMQVENTNFNWADDDIQFQIRQPQYAAEYPVSVLENLARNVTFKVPADQNTMTSAIEALARERQAFEQMKRNHEDAMKSREVELNAQEATLQARERQLHANTETLAAERQQLILQQSQFRAQQAQAQAQAQAQAQTQSQPRTSQTQSPAAQVSPSPAQAAQPAHAPQLQHQMPPPHQQPQPRSGNVYMGGGYGAQEWQPDQRTWGNEGAMGAPGFDMYQGAYPGSYAQRNYHMAGGHRGQMRSGNLQQQQFPGNRMQPMMPPPQQYSRSMAPLGASRQQQMDMNFGGRSQQSYNPAPNTGYPQRSAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRW5</accession>
    <name>A0A3S7WRW5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_120006200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRW5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0160"/>
    <dbReference type="OrthoDB" id="267838at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="814" mass="91681" checksum="5E837225B0F018D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WS88</accession>
    <accession>E9BB78</accession>
    <name>A0A3S7WS88_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_17590</name>
        <name evidence="4" type="ORF">CGC21_32965</name>
        <name evidence="3" type="ORF">LDBPK_130030</name>
        <name evidence="1" type="ORF">LdCL_130005300</name>
        <name evidence="2" type="ORF">LDHU3_13.0050</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859215.1">
        <property type="nucleotide sequence ID" value="XM_003859167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WS88"/>
    <dbReference type="GeneID" id="13390802"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0050"/>
    <dbReference type="OMA" id="NWLYTPV"/>
    <dbReference type="OrthoDB" id="277159at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5428372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="201" mass="22799" checksum="5071351DEEB25B08" modified="2019-05-08" version="1">MAEPRIKQLWRAATEVPEDQRNHLQHLYESIEQLSRRCRHLENASERKSVVIEDLRAHVARLEELFGKSQGEMAYAQQQLEFVVMSLESQHGIVADHTEQLRLFAGESTHRGYATTQGNAQRSLLLLMGNWLYTPVVHFAKGVYTLFSPIITTAQSLSLLNSDVLHRNASERLRWGAARKGDLLGMLQRGALDPDSAANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT89</accession>
    <accession>E9BC47</accession>
    <name>A0A3S7WT89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 4 gamma type 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Eukaryotic_translation_initiation_factor_4_gamma_ type_1_putative/GeneDB:LmjF.15.0060</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">MIF4G domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_1910</name>
        <name evidence="5" type="ORF">LDBPK_150060</name>
        <name evidence="3" type="ORF">LdCL_150005500</name>
        <name evidence="4" type="ORF">LDHU3_15.0090</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859531.1">
        <property type="nucleotide sequence ID" value="XM_003859483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT89"/>
    <dbReference type="GeneID" id="13392894"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0090"/>
    <dbReference type="OMA" id="RFLMMDL"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000086">
        <property type="entry name" value="Eukaryotic initiation factor 4a, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF73">
        <property type="entry name" value="MIF4G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="199"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114125" checksum="27DF0F9379836466" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTR1</accession>
    <accession>E9BCM3</accession>
    <name>A0A3S7WTR1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_160190</name>
        <name evidence="2" type="ORF">LdCL_160006800</name>
        <name evidence="3" type="ORF">LDHU3_16.0220</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859707.1">
        <property type="nucleotide sequence ID" value="XM_003859659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTR1"/>
    <dbReference type="GeneID" id="13393075"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0220"/>
    <dbReference type="OMA" id="HHRTAHH"/>
    <dbReference type="OrthoDB" id="263775at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16278" checksum="31A305F39055E627" modified="2019-05-08" version="1">MEDAPRTKLSSYVTPHEAVQAQPAQHGATVVRSGSSATEGGSILFFSSVQKKGGAFTASERETYAQLHRSRAIPNVNRGRNAGNVMGSGVSAKSVARKYADLEKDREALEISQAKATVAGWKRPRFTLDDSPSEDDGEDAEATAKQPRTRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTR9</accession>
    <name>A0A3S7WTR9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Inositol 1,4,5-trisphosphate receptor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_160007800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0350"/>
    <dbReference type="OrthoDB" id="278056at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF99">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2397"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2440"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2519"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2574"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2657"/>
            <end position="2676"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="11">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2874" mass="316431" checksum="2D3A66966395654F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUR3</accession>
    <accession>E9BDI4</accession>
    <name>A0A3S7WUR3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA-binding protein 27, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA-binding_protein_27_putative/GeneDB:LmjF.18.00 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_39695</name>
        <name evidence="7" type="ORF">CGC21_3500</name>
        <name evidence="6" type="ORF">LDBPK_180030</name>
        <name evidence="4" type="ORF">LdCL_180005200</name>
        <name evidence="5" type="ORF">LDHU3_18.0040</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860017.1">
        <property type="nucleotide sequence ID" value="XM_003859969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUR3"/>
    <dbReference type="GeneID" id="13393390"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0040"/>
    <dbReference type="OMA" id="TERPCYY"/>
    <dbReference type="OrthoDB" id="259597at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001323">
        <property type="entry name" value="RNA-binding protein 27, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5429217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP53323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP55338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="344" mass="37671" checksum="53AD75E9CDAC5581" modified="2019-05-08" version="1">MPNDTAVVYIFLDDANKAVSMEDVKEWLQIINDVVEIKLQFDAATERPCYYVEFRSPVAAQQAVQYLNGARLKNCVVTIQSRVYLAAAETQGSASGSGESPSAAGGTPPVTHKRCRETSELPFNHLLPPELQMDPPLAKYLPQLEKSELYSSDAVAMWQQLQAAQKELVEMYHDLEITAAQIADCDAQLTQLLHMSWIAPASNGVMISQSPSSGPGRKTVLQAPHFLCHERAIAFDAHTPSRVVALLTDCFGPLSLCSDAVTQTGFFLVVRFVFAADEALFLAAATASGSTEVTKKREQSQGAEWRSVVQGLGWRPTTSVARVHHLFSVELDAPLQRIVRDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVH7</accession>
    <accession>E9BEB8</accession>
    <name>A0A3S7WVH7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Surp module family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_18985</name>
        <name evidence="4" type="ORF">LDBPK_191260</name>
        <name evidence="3" type="ORF">LdCL_190017700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860301.1">
        <property type="nucleotide sequence ID" value="XM_003860253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVH7"/>
    <dbReference type="GeneID" id="13386113"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1520"/>
    <dbReference type="OMA" id="HWMRNSE"/>
    <dbReference type="OrthoDB" id="248600at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000022">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP50946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="227" mass="24870" checksum="9B904A95F5B2F159" modified="2019-05-08" version="1">MADYNAAGDGTAVVDDNVPPGITTKQDEIIQYVAKYVVASCDGARYQDKVRTRTKHNPYFDFLNAKHPYHQYYQYLLESYRHWMRNSEAVGAGTWGGGVDAMQGQGQQQQWNEEDYYQYYGAYAGQASGIEFQGNAAAQLGERSSYVDASSSAHAQNASSGVDPTLYEPESVTVTGYGAGYDPSAVGPEPAQAATTAGSGEAQAEEDEDDEYELVMENGQWVSRKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW18</accession>
    <name>A0A3S7WW18_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine peptidase, Clan CA, family C2, putative</fullName>
            <ecNumber evidence="5">3.4.22.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_200016700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.33" evidence="5"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW18"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1530"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="321"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="821" mass="91542" checksum="CFDACE25E70CBA2A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWR2</accession>
    <accession>E9BFH7</accession>
    <name>A0A3S7WWR2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_34570</name>
        <name evidence="8" type="ORF">LDBPK_211910</name>
        <name evidence="7" type="ORF">LdCL_210024800</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860708.1">
        <property type="nucleotide sequence ID" value="XM_003860660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWR2"/>
    <dbReference type="GeneID" id="13386539"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210024800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2280"/>
    <dbReference type="OMA" id="WWRHNAD"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001754">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP49406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="931" mass="102230" checksum="6A5C0BEFAD81800A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX05</accession>
    <accession>E9BFR2</accession>
    <name>A0A3S7WX05_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_32720</name>
        <name evidence="11" type="ORF">LDBPK_220430</name>
        <name evidence="10" type="ORF">LdCL_220010600</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860793.1">
        <property type="nucleotide sequence ID" value="XM_003860745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX05"/>
    <dbReference type="GeneID" id="13389358"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0740"/>
    <dbReference type="OMA" id="CITPAIE"/>
    <dbReference type="OrthoDB" id="21525at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="9"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="584"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="889" mass="97182" checksum="E08826ACF806D026" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXC7</accession>
    <name>A0A3S7WXC7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase, central domain/Kelch motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_220015900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1360"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000172">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="886"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1326" mass="139238" checksum="3CD3DD5F7778BC6E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXE4</accession>
    <name>A0A3S7WXE4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pentamidine resistance protein 1</fullName>
            <ecNumber evidence="13">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_230007200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="13"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0280"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="250"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="648"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="954"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1561" mass="171962" checksum="901F07F23999A927" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXS2</accession>
    <name>A0A3S7WXS2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_230017700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXS2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1430"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18623">
        <property type="entry name" value="GH32_ScrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="396"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="527" mass="59885" checksum="5E920F80D5CDC32E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY30</accession>
    <accession>E9BGQ4</accession>
    <name>A0A3S7WY30_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_11675</name>
        <name evidence="17" type="ORF">CGC21_15885</name>
        <name evidence="15" type="ORF">LDBPK_240420</name>
        <name evidence="13" type="ORF">LdCL_240009100</name>
        <name evidence="14" type="ORF">LDHU3_24.0530</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861132.1">
        <property type="nucleotide sequence ID" value="XM_003861084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY30"/>
    <dbReference type="GeneID" id="13390582"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0530"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.860:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000020">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU79124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5430373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP52182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="307" mass="34354" checksum="5EF9ABA6FD1BB533" modified="2019-05-08" version="1">MPSDESRWCLIESDPAVFREIIQTVGVKGVSVEDLIMLDSSMLEQYEHVYGLVLLFKWQSSEQAPPLGTVVKDAPVFFAKQVIHNACATLAIINTLCNYSDQVELGPKVQRYLSFCQELDPEMRGSLLDSFDELREAHNSFAPHSAFTKDGPSPKDADVYHFASFVYRHGHIWELDGLQEGPLQCREATEANYREALVEVVQRRIDDIAAKDTTGAGQGISFSLMTIVDDPVTVLEKKIAALQAEEKPTTALDEELAEMLSLRKKDKEANVRRRHDYNAMIVALLKSLAERGKLEKIVAEVQAKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYF6</accession>
    <accession>E9BH24</accession>
    <name>A0A3S7WYF6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16410</name>
        <name evidence="4" type="ORF">LDBPK_241620</name>
        <name evidence="2" type="ORF">LdCL_240021300</name>
        <name evidence="3" type="ORF">LDHU3_24.1960</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861252.1">
        <property type="nucleotide sequence ID" value="XM_003861204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYF6"/>
    <dbReference type="GeneID" id="13391174"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1960"/>
    <dbReference type="OMA" id="VQAPLCP"/>
    <dbReference type="OrthoDB" id="267435at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="953" mass="99653" checksum="0024F47934009825" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYP8</accession>
    <accession>E9BHB3</accession>
    <name>A0A3S7WYP8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Qc-SNARE protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Qc-SNARE_protein_putative/GeneDB:LmjF.25.0090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_250090</name>
        <name evidence="9" type="ORF">LdCL_250006000</name>
        <name evidence="10" type="ORF">LDHU3_25.0130</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861340.1">
        <property type="nucleotide sequence ID" value="XM_003861292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYP8"/>
    <dbReference type="SMR" id="A0A3S7WYP8"/>
    <dbReference type="GeneID" id="13391509"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0130"/>
    <dbReference type="OMA" id="MKAMAGH"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000178">
        <property type="entry name" value="Qc-SNARE protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5430582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13433" checksum="A7E95A921BBA9A52" modified="2019-05-08" version="1">MQSSLYGNSKAAKASTNPTNRYEHMEEEIHRENEAMLRALGSSVAHMKTMAGHLNREAEEQNELLRSLDKVFQTARCGVNSAVSSVKSVMGRYGWKHTAAFGCIGFLLLYFIYAVFLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZV4</accession>
    <name>A0A3S7WZV4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_260019100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZV4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1660"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="715"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="905" mass="97803" checksum="11F1E938F3EC9A22" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0Q1</accession>
    <name>A0A3S7X0Q1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270017700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0Q1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270017700"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10268" checksum="3B3C2250B4285DE6" modified="2019-05-08" version="1">MSSDSAVAALSAAMTSPQKSPRSSPKKTAAKKAAAKKAGAKKAGAKKAVRKVATPKKPAKKAAKKAAKKPAKKVAKKAAKKPAKKAAKKPAKKAAKKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X190</accession>
    <accession>E9BKB1</accession>
    <name>A0A3S7X190_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_13730</name>
        <name evidence="15" type="ORF">CGC21_21885</name>
        <name evidence="13" type="ORF">LDBPK_280730</name>
        <name evidence="11" type="ORF">LdCL_280011900</name>
        <name evidence="12" type="ORF">LDHU3_28.0900</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862172.1">
        <property type="nucleotide sequence ID" value="XM_003862124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X190"/>
    <dbReference type="SMR" id="A0A3S7X190"/>
    <dbReference type="GeneID" id="13386908"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0900"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF505">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5431453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP40561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP54218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="301" mass="34388" checksum="EB56B42EBE74F19F" modified="2019-05-08" version="1">MSVDSIIEQLLEVRGAKPGKQVQLAENDVKQLAIRTREILLSQPPLLELEAPIKICGDIHGQYYDLIRLFENGGFPPTANYLFLGDYVDRGKQGLETICLVFAFKVKFPENFFILRGNHECASINRIYGFFDECKRRYNIRLWKAFTDTFNCLPVACIIDDKIFCCHGGLSPELQTMDQIKKITRPCDVADTGLICDLLWSDPEEGLSGWGENDRGVSFTFGQDIVEKFLNKHQFELICRAHQVVEDGYQFFAKRKLITIFSAPNYCNEFDNSGAVMTVDNELMCSFQILKPSVKKPKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1E3</accession>
    <accession>E9BKC5</accession>
    <name>A0A3S7X1E3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_13670</name>
        <name evidence="9" type="ORF">CGC21_21945</name>
        <name evidence="7" type="ORF">LDBPK_280870</name>
        <name evidence="5" type="ORF">LdCL_280013300</name>
        <name evidence="6" type="ORF">LDHU3_28.1040</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862186.1">
        <property type="nucleotide sequence ID" value="XM_003862138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1E3"/>
    <dbReference type="SMR" id="A0A3S7X1E3"/>
    <dbReference type="GeneID" id="13386922"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1040"/>
    <dbReference type="OMA" id="IKQYEYV"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000371">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5431467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP40549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP54230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="149" mass="16599" checksum="8B846D498F0204AB" modified="2019-05-08" version="1">MSANPVILEDTFTVNGVNTEGTVYLRVSRIRCVNQDGSLTITTDINSEEFPVSTNDRLTIVLANSLELGGKTGSKYYDHSVYHRETRLNDCDYAMHGRVYGHEVVENGLEVNVHISCGGLLVNIVGKPQGLRDVHYNSDVYILIKRVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1M9</accession>
    <name>A0A3S7X1M9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_280023800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2480"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001155">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1609"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="618"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1629" mass="171949" checksum="441EB2B319331030" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Z8</accession>
    <name>A0A3S7X2Z8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TBC1 domain family member 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_300008400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Z8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3550"/>
    <dbReference type="OrthoDB" id="73307at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="448"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="881" mass="93841" checksum="7F80E7FD03C43EC0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3K2</accession>
    <name>A0A3S7X3K2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-editing substrate-binding complex 7 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300026300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3K2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2850"/>
    <dbReference type="OrthoDB" id="259184at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd23679">
        <property type="entry name" value="RESC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058774">
        <property type="entry name" value="RESC7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26165">
        <property type="entry name" value="RESC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 7 protein" evidence="1">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24002" checksum="0458BA94846065C7" modified="2019-05-08" version="1">MFAQLGRHPVCASCRVLRASRPACRSSVRAVASSTRVCYALPNKGTGATIAPPPFQGEACTYPPISPTPGASDTVSIGQRLYSLTQFCTKVCLGPKRDDAELERLATEAWNLLQSISEEEVEALPLRDVAEIVVAYNHFCGFWANGLNGPARAVRDGKSSGQVSTSSSQFGVDEQPQTYPIMERFDVASGNGETLLNKAVPQPLDGCEVPVRRASPLDEILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3K6</accession>
    <name>A0A3S7X3K6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_300030500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3K6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300030500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3360"/>
    <dbReference type="OrthoDB" id="286427at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8892" checksum="21BC1758DCEA2EE5" modified="2019-05-08" version="1">MLGLACFRIAEDDAANRRDYALLKLAEEERRAMILHRNPDGRPIVRVVLAYPGVDGEGRGEPSRVSEKVKTTIAAIPLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X454</accession>
    <name>A0A3S7X454_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310008300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X454"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0380"/>
    <dbReference type="OrthoDB" id="262042at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055777">
        <property type="entry name" value="DUF7353"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF2">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24044">
        <property type="entry name" value="DUF7353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="778"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="88"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1139" mass="127378" checksum="F29DC8EA266C71B0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4G8</accession>
    <name>A0A3S7X4G8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310022200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2630"/>
    <dbReference type="OrthoDB" id="264516at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1628" mass="173701" checksum="63A271EBD4FC9360" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X508</accession>
    <name>A0A3S7X508_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310037100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X508"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5020"/>
    <dbReference type="OrthoDB" id="267824at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25811" checksum="EBA2D6E81C99AE0D" modified="2019-05-08" version="1">MLSQTGGAVAVNEISQQHSTEQAMAAKEMAAENQVHVTLPEEVRERRRSRQSSQARNGSHEAPIISYGEAAPKQTVSRVLVRMPNEVRRRRSLSREARKSHTHTQLEESEMPNATPKAMPEAAAMSTAEDGRVSPEKQCPEPELPANGLAMQPAVEEAVDHEPPTEPSPAAEEAERSGRLTDAASRVETELTGSDSAAVIEEANQEMEDNAAPHENNDAHPMIKGKEKDKHGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X521</accession>
    <name>A0A3S7X521_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphoglycan beta 1,3 galactosyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_310040400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X521"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310040400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5470"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000128">
        <property type="entry name" value="Phosphoglycan beta 1,3 galactosyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="80"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="242"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="558"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="902"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123775" checksum="79AB3EDCFDA96D51" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5S6</accession>
    <name>A0A3S7X5S6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320032900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5S6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3380"/>
    <dbReference type="OrthoDB" id="266907at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="725" mass="78563" checksum="67D400519504B32A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6D1</accession>
    <accession>E9BPU2</accession>
    <name>A0A3S7X6D1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_38555</name>
        <name evidence="12" type="ORF">LDBPK_330130</name>
        <name evidence="11" type="ORF">LdCL_330006200</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863837.1">
        <property type="nucleotide sequence ID" value="XM_003863789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6D1"/>
    <dbReference type="SMR" id="A0A3S7X6D1"/>
    <dbReference type="GeneID" id="13391602"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0150"/>
    <dbReference type="OMA" id="TPRQWWC"/>
    <dbReference type="OrthoDB" id="2163581at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP53860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="366" mass="40876" checksum="042541790E0C7ACE" modified="2019-05-08" version="1">MAVDDMGAELWALVHHLFRKYRRDPRKAVQELTLRTHAEWTREPGVPLPTIAPDVKESPWYHEMCSRRASLLEQLHAKHKRDIADAQELVSSLYPDGCNLSEYAEALRTSAALLPCLVPSETIDHLIQKRGADFQEKGRHEVSHDELVSDVIEGLMIRVLIPRQWWCRGTSSVARATRTGIQSNPPTLYIEYERPAGVPHVRRIHLRTNLRPDMPTAQLARRLAKTHEALLSEAQFQSLLIRCQRLQGQSPASSAANAPSTGTVASTFAAALLPTIANTASPDAPTARSSKPQKADLGLLYRDPDAALENVDLNDADEVTLQEFKEVMNERFKAKVVKPGDPGYVYDKRVEVSKPTQSSGWDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6Q1</accession>
    <accession>E9BQA3</accession>
    <name>A0A3S7X6Q1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HEAT repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_37775</name>
        <name evidence="4" type="ORF">LDBPK_331720</name>
        <name evidence="3" type="ORF">LdCL_330023900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863998.1">
        <property type="nucleotide sequence ID" value="XM_003863950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6Q1"/>
    <dbReference type="GeneID" id="13392393"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2580"/>
    <dbReference type="OMA" id="AFQGPWA"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="2">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="1">
        <location>
            <begin position="334"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="101252" checksum="B7788AF3E722BDA5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8C5</accession>
    <name>A0A3S7X8C5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340037600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8C5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_044300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5000"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="257" mass="28926" checksum="BC10B3CCA1AE0087" modified="2019-05-08" version="1">MLPQATRHRIMSGVVTALVKRHPILTASRVRIVVVSVFCFLLAVALRLLFRYVHLSSKDTKRISGRRSRTAKKEHSKSHGGSRSSGGGGSSSTRKKTDPSLPTVLMLIGIHGSGKSFWAKRYTEIVHKSYLIISSDAIRSRLTGSINNYTREVEVEESILKEVMHTLELRRSCIVDDCQHNLSPEFRAKLRALAPDGKVNRVVKIFSVKPSYAMMRIQSDIEEGTARYAPTMVELEKQGEQVAEFEATNKDDDWMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8N3</accession>
    <accession>E9BRP5</accession>
    <name>A0A3S7X8N3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_0870</name>
        <name evidence="13" type="ORF">CGC21_5685</name>
        <name evidence="12" type="ORF">LDBPK_350130</name>
        <name evidence="10" type="ORF">LdCL_350006300</name>
        <name evidence="11" type="ORF">LDHU3_35.0200</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864606.1">
        <property type="nucleotide sequence ID" value="XM_003864558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8N3"/>
    <dbReference type="SMR" id="A0A3S7X8N3"/>
    <dbReference type="GeneID" id="13387484"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0200"/>
    <dbReference type="OMA" id="GMEWIVQ"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5434041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP44304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP46516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="186" mass="20929" checksum="CB315F06F0DB06AD" modified="2019-05-08" version="1">MGLLSIIKKTKRKEREMRILMLGLDNAGKTTCVKKLCGKDTSSISPTLGFQITALTFRGCTLNVWDVGGQQSLRSYWRNYFESTDGLVWVVDSNDVKRLLMCKEELHHLLQEERLAGASLLVFLNKIDIPTALSPQEIARLLDVDTIRQGKRHVHLCACSARTGEGLLDGISWMVDDVSKRMYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X934</accession>
    <name>A0A3S7X934_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_350020900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X934"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2140"/>
    <dbReference type="OrthoDB" id="272090at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="84415" checksum="42254FC8F23B378F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAC1</accession>
    <accession>E9BTC8</accession>
    <name>A0A3S7XAC1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3592 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_12665</name>
        <name evidence="4" type="ORF">LDBPK_360690</name>
        <name evidence="3" type="ORF">LdCL_360011800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865185.1">
        <property type="nucleotide sequence ID" value="XM_003865137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAC1"/>
    <dbReference type="GeneID" id="13388071"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0850"/>
    <dbReference type="OMA" id="AYRSVRC"/>
    <dbReference type="OrthoDB" id="268624at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3592" evidence="2">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="188" mass="21342" checksum="650EAAF8B06068A0" modified="2019-05-08" version="1">MPWYLSTFRVGFCAIYAYFGYVQIRWLLETEDRYRRSSTWKPAVGTIFDHKVVMTRGGSSYVQYKFNVDGVEYIGDRFRSGGIHKEEMVSNPTLLGAGTQLVVYYNPADPSESAIKLQADRGAESVFVIGSLLSFLIAFRAVRCETILPNMFYRFLGVNRRVGGISGLRQARPHAKQRMKYGKHSGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAI4</accession>
    <name>A0A3S7XAI4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_360015700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1400"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="10">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="10">
        <location>
            <begin position="194"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="9">
        <location>
            <begin position="299"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="11">
        <location>
            <begin position="673"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1296" mass="144953" checksum="2BE832D6C4D83C03" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAZ4</accession>
    <accession>E9BTS6</accession>
    <name>A0A3S7XAZ4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_13370</name>
        <name evidence="5" type="ORF">LDBPK_362170</name>
        <name evidence="4" type="ORF">LdCL_360027400</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865332.1">
        <property type="nucleotide sequence ID" value="XM_003865284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAZ4"/>
    <dbReference type="GeneID" id="13388218"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2820"/>
    <dbReference type="OMA" id="WDMKDHP"/>
    <dbReference type="OrthoDB" id="251965at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF514">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="478"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="914" mass="97395" checksum="E095D88682D530E9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-02-20" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A2CIK6</accession>
    <accession>E9BQG2</accession>
    <name>A2CIK6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">g6pdh</name>
        <name evidence="24" type="ORF">CGC20_2515</name>
        <name evidence="23" type="ORF">CGC21_25385</name>
        <name evidence="22" type="ORF">LDBPK_340080</name>
        <name evidence="20" type="ORF">LdCL_340005900</name>
        <name evidence="21" type="ORF">LDHU3_34.0110</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2007" name="Int. J. Parasitol." volume="37" first="149" last="160">
            <title>The Leishmania donovani complex: genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH, and FH), new targets for multilocus sequence typing.</title>
            <authorList>
                <person name="Zemanova E."/>
                <person name="Jirku M."/>
                <person name="Mauricio I.L."/>
                <person name="Horak A."/>
                <person name="Miles M.A."/>
                <person name="Lukes J."/>
            </authorList>
            <dbReference type="PubMed" id="17027989"/>
            <dbReference type="DOI" id="10.1016/j.ijpara.2006.08.008"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">MCAN/SD/2000/LEM3946</strain>
            <strain evidence="17">MHOM/ET/2000/HUSSEN</strain>
            <strain evidence="19">MHOM/IN/1980/DD8</strain>
            <strain evidence="15">MHOM/IN/1996/THAK35</strain>
            <strain evidence="14">MHOM/IN/2000/DEVI</strain>
            <strain evidence="16">MHOM/SD/1982/GILANI</strain>
        </source>
    </reference>
    <reference evidence="22 25" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20 26" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 26">LdCL</strain>
        </source>
    </reference>
    <reference evidence="27" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">FDAARGOS_360</strain>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="28" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="21" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="DQ449778">
        <property type="protein sequence ID" value="ABF20350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449779">
        <property type="protein sequence ID" value="ABF20351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449781">
        <property type="protein sequence ID" value="ABF20353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449782">
        <property type="protein sequence ID" value="ABF20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449786">
        <property type="protein sequence ID" value="ABF20358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ449795">
        <property type="protein sequence ID" value="ABF20367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864173.1">
        <property type="nucleotide sequence ID" value="XM_003864125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A2CIK6"/>
    <dbReference type="SMR" id="A2CIK6"/>
    <dbReference type="GeneID" id="13392582"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0110"/>
    <dbReference type="OMA" id="PDEGIQM"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="75"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="262"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF20350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF20351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF20353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABF20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABF20358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABF20367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAC5433559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBZ37491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP50529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="562" mass="63299" checksum="1FCD94ECBCFB000C" modified="2007-02-20" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7L0</accession>
    <accession>A0A3S5H513</accession>
    <name>E9B7L0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nop14-like family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_020630</name>
        <name evidence="8" type="ORF">LdCL_020011900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857958.1">
        <property type="nucleotide sequence ID" value="XM_003857910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7L0"/>
    <dbReference type="GeneID" id="13390089"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0800"/>
    <dbReference type="OMA" id="LEPARYQ"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="PhylomeDB" id="E9B7L0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="870"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="910" mass="100667" checksum="E012B68A58F0603C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8E9</accession>
    <accession>A0A3S7WP45</accession>
    <name>E9B8E9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LDBPK_050590</name>
        <name evidence="15" type="ORF">LdCL_050011000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858246.1">
        <property type="nucleotide sequence ID" value="XM_003858198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8E9"/>
    <dbReference type="GeneID" id="13391299"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0670"/>
    <dbReference type="OMA" id="AIRCWEE"/>
    <dbReference type="OrthoDB" id="273119at2759"/>
    <dbReference type="PhylomeDB" id="E9B8E9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="313"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="625"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="811"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="870"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU75965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1006" mass="106010" checksum="2FC99DF9F146F67B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAT1</accession>
    <accession>A0A3S7WRS1</accession>
    <name>E9BAT1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_110930</name>
        <name evidence="3" type="ORF">LdCL_110015100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859069.1">
        <property type="nucleotide sequence ID" value="XM_003859021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAT1"/>
    <dbReference type="GeneID" id="13389815"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1160"/>
    <dbReference type="OMA" id="PLFRRYN"/>
    <dbReference type="OrthoDB" id="272691at2759"/>
    <dbReference type="PhylomeDB" id="E9BAT1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="377" mass="42430" checksum="8ECC771F1DC58238" modified="2011-04-05" version="1">MVFDVNGDFVENEQQFIEAARKSINLTIKLQNTSGMSELIARVLEDDDRRASGAISTSALDFDELLRTTPRFNFLSGDHPLFRRYNKRLSQQRQAAALIAQRTAEAELQRQAEIKERLRKALEEEAAVQKKKEQEKAELQRMRAAQEPARFVPEEPFLKIIKDESSFGQVERELKKPEPAAEPKVESKAEVATSEDITNTATGASTTLSNDVAATISAEELLVLVGVPTETMEATTPALEDLAKAIALPPSGNTTTYVALPAEEYTLCSGERVVSIIKKRSGPIPAPPPGKPPVINKAAASRLNEPAKRVKPVEKMVRNRTPSNEQPYKSRHRSRSPRSRRRSERDHSSKERSRRHRRDEPSTHRHHKNSRDSKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEC6</accession>
    <accession>A0A3S7WVM5</accession>
    <name>E9BEC6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-bound O-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_191370</name>
        <name evidence="7" type="ORF">LdCL_190019400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860309.1">
        <property type="nucleotide sequence ID" value="XM_003860261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEC6"/>
    <dbReference type="GeneID" id="13386121"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1650"/>
    <dbReference type="OMA" id="CYKCRTE"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="PhylomeDB" id="E9BEC6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="734" mass="81416" checksum="3FE8FF297397EADF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFL6</accession>
    <accession>A0A3Q8IC51</accession>
    <name>E9BFL6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein DNAJ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_220009</name>
        <name evidence="8" type="ORF">LdCL_220005800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860747.1">
        <property type="nucleotide sequence ID" value="XM_003860699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFL6"/>
    <dbReference type="GeneID" id="13386568"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220009"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220009.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0130"/>
    <dbReference type="OMA" id="FKFTHLD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="PhylomeDB" id="E9BFL6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000010">
        <property type="entry name" value="Heat shock protein DnaJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="331" mass="36473" checksum="68A6C0B7FABA8755" modified="2011-04-05" version="1">MFGGGMDDMLNAMLNGGMGSFGGGRGGRVQRSRRGRDAAYALPVTLEDLYNGKMVQIERKRTVMCPDCKGTGSKRRSLPRGGNMCPVCRGSGSRVMVRQMGMMVQQMQVVCDACQGSGEHIDPRNRCGRCSGNKTVEVDASVQVVVEKGMAHRQRITFPRMADEELGVERAGDFVVVLQQVKHDVFTRDDCDLHMQHHLSLAEALCGFQFKFTHLDGRELVVRQARGTITKPGDVKCVIGEGMPLHKQANRFGNLIIEFNVKYPDRIEAGQLQLLREALPPPKSVDVAADNEAGDVCYVTREDLSVLEEEIKKDEEAEEENEGPQTGCAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIR7</accession>
    <accession>A0A3Q8ID20</accession>
    <name>E9BIR7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LDBPK_262560</name>
        <name evidence="15" type="ORF">LdCL_260031500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861840.1">
        <property type="nucleotide sequence ID" value="XM_003861792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIR7"/>
    <dbReference type="GeneID" id="13389088"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3290"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="PhylomeDB" id="E9BIR7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000031">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="480" mass="53175" checksum="E9CBC2029F9ECFA0" modified="2011-04-05" version="1">MLLTDRGNPSVPPPNWEPLSSSALFDESGKARPDVVREHLTKEGLLQEADALTIITQCALIWKDEPNVLRLDGPVVIAGDIHGQFFDLLNLLSIGGDPSQQKYIFLGDYVDRGCFGMEVILLLMCYKICYPETMIMLRGNHESRHLTTYFNFKREVLYKYSIAVYNAIMSAFDCLPLACILNDRFLCVHGGLSPELKRISDIGAIHRFREPPSSGPMCDLLWADPLDEKEEDPAAAPLFVPNTTRGCSYVYSNAAACNFLEENGLITIIRGHEAQDEGYHLYKKTNKGFPAVICIFSAPNYCDTYDNRAAVVMLNRNIMSIRQFNSSPHPYYLPNFMNAFTWSLPFVEEKLLDIGTNVLHPIDGSEDHLLLDGAEATTAAPTPGANTESRDGNVLEQRGEKIREKILAMGRLSRMFHTLCEGGESRLPPKGLAGGILPQGGLPCGPDSVQAAGRGLQQSKEMDSANGRWQDCLIEGDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKB9</accession>
    <accession>A0A3S5H7I9</accession>
    <name>E9BKB9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_280810</name>
        <name evidence="13" type="ORF">LdCL_280012700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862180.1">
        <property type="nucleotide sequence ID" value="XM_003862132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKB9"/>
    <dbReference type="GeneID" id="13386916"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0980"/>
    <dbReference type="OMA" id="VHIHHGK"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="E9BKB9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="163"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="425"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="505"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU80231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="736" mass="82791" checksum="5F0F03B8783631ED" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKV6</accession>
    <accession>A0A3S5H7L3</accession>
    <name>E9BKV6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_291580</name>
        <name evidence="3" type="ORF">LdCL_290021400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862577.1">
        <property type="nucleotide sequence ID" value="XM_003862529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKV6"/>
    <dbReference type="GeneID" id="13387313"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2290"/>
    <dbReference type="OMA" id="CRQVHIG"/>
    <dbReference type="OrthoDB" id="266417at2759"/>
    <dbReference type="PhylomeDB" id="E9BKV6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33205" checksum="E1FCE98D5D67EE21" modified="2011-04-05" version="1">MYNGIAAKAKSTTKGSENPFAAARVALLSRFKSVVCRSSVMRVWSVSQVPPRLLVFSFPVSTSYRFLSSIAVAPVCPRTRPPQAMGLWRKRSCVRVHTRQGSTQQKKSRERQSAPQPLVRATVSPSISVVRTRPTAVPLAMPLLSTPRPSYPASLSSQRLLRLPGICSTSTSGLTCCRQVHIGHSTDVHRWRNPEKEEVQRQFRGGVKLGSHIAKVREQQAKERELIEQDKFTDWRLVYNYSIGAALLLIGLNVILAFVEPNPSPEYVPYTESVVPASNVSDTMAESGQAPLSDAGPARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKX3</accession>
    <accession>A0A3Q8IDS8</accession>
    <name>E9BKX3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein S linking to the trans Golgi network, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_291750</name>
        <name evidence="11" type="ORF">LdCL_290023100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862594.1">
        <property type="nucleotide sequence ID" value="XM_003862546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKX3"/>
    <dbReference type="GeneID" id="13387330"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2510"/>
    <dbReference type="OMA" id="RFYLQHM"/>
    <dbReference type="OrthoDB" id="262164at2759"/>
    <dbReference type="PhylomeDB" id="E9BKX3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="376" mass="40312" checksum="090F38A6579457C0" modified="2011-04-05" version="1">MAIGLGRTISSPVFLFFQVLHGMSLFFVMLGVTRVLLGMAELSMSTTAVEDRTPPQVAPFALSLAMKGQPYAGPAPATPRGLHRPDRLGEIVYQHASMFDLLVEDTLSSTTTTLAPAPPAASLSFFEKLSYCFHVPLASLFVSTVDVRAGTTVGAQDLRPGDVAAPDGVVKKDVRLSGADAPAAGQLRDGSERRFYLQHMLAALLCSYPLATLLQRRKLVLDFVVTIYLAYWLLADIVLWRLLGGGLHWWAACVLGMTVMYGATYVICRRKELQEIRFSGGGTAGTGAGVPATTTMWLKDCRGEDDIVGEEMRVISRETQRHSGSGGADAHGSSKPHDAAGRSRVPASAQSSNGAKVVAVDVSRAPEEATHKHKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ64</accession>
    <accession>A0A3Q8IDQ6</accession>
    <name>E9BQ64_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_331330</name>
        <name evidence="2" type="ORF">LdCL_330019500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863959.1">
        <property type="nucleotide sequence ID" value="XM_003863911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ64"/>
    <dbReference type="GeneID" id="13392354"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1980"/>
    <dbReference type="OMA" id="SCALRKR"/>
    <dbReference type="OrthoDB" id="264691at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ64"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="976" mass="105840" checksum="A10CA8F99EA0EABF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRB2</accession>
    <accession>A0A3S7X8A0</accession>
    <name>E9BRB2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-Tyr-tRNA(Tyr) deacylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_343140</name>
        <name evidence="5" type="ORF">LdCL_340040300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864473.1">
        <property type="nucleotide sequence ID" value="XM_003864425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRB2"/>
    <dbReference type="SMR" id="E9BRB2"/>
    <dbReference type="GeneID" id="13387352"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340040300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5310"/>
    <dbReference type="OMA" id="QQCLHAK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="PhylomeDB" id="E9BRB2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000008">
        <property type="entry name" value="Putative D-tyrosyl-tRNA(Tyr) deacylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF1">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU82681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ37791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23530" checksum="2488711F1FF22120" modified="2011-04-05" version="1">MRLFAHVPQPGLFIHYGKIVRAGHIMTIRVMLQAMDQGHLLVNNVDKYVRAGRGVMVYIAFLSDRDSAPITDEALRHAVDVLLQTKIFTHFSPEKMINQPQSLEECPEMDILIVPQASLGGKVKGRSVQFHQLVAKGVGAALYDRFCHFVRVARGVDESRVDANGAPLNEGDAPKAEGWIKYNSRVISGTFGNRQGLRFESEGPFTHMFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSC1</accession>
    <accession>A0A3S7X9B6</accession>
    <name>E9BSC1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_352510</name>
        <name evidence="2" type="ORF">LdCL_350030000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864830.1">
        <property type="nucleotide sequence ID" value="XM_003864782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSC1"/>
    <dbReference type="GeneID" id="13387708"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350030000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3250"/>
    <dbReference type="OMA" id="QFQVSKK"/>
    <dbReference type="OrthoDB" id="272478at2759"/>
    <dbReference type="PhylomeDB" id="E9BSC1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44141" checksum="8FAC2E5F28E80E31" modified="2011-04-05" version="1">MATEDELRELLPKMRFNKEFKKKQKYKYKKRVEAREKEREMITGKRRPASKQIQSASDGAKAKTTATKKSGGAGTAGAKGKPKTRVPKLKVANVETGKETLTKKKARELVQENRKKKISAKKEPKLAAKSTRAGAVTAAVVSTETLEAKQSRARVTKDELPATAAQAASLVEPKQTLTQAERDRELLARAIRGDDLLGSDAATGVADGVAFIRQDPSLYPDHAFLDDYAEKKHAEAVSADELLKNAHHFFKKLSKRERALNKVAKEHINHLRAVNRRGGDKQGFRYVVPKNVKQVVRELISAQKARDGEEDPESLIDTEQLVSTFGGDGVAETSEKPVRRSRRRRSRTYSDFYQFQVSRRWTRNAENFLKRSRPNKLLFEAKKHQRTIKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8U9</accession>
    <accession>E9BAC9</accession>
    <name>A0A3Q8I8U9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_35705</name>
        <name evidence="9" type="ORF">CGC21_23465</name>
        <name evidence="8" type="ORF">LDBPK_100840</name>
        <name evidence="6" type="ORF">LdCL_100015200</name>
        <name evidence="7" type="ORF">LDHU3_10.1200</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000051">
        <property type="protein sequence ID" value="TPP52605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858920.1">
        <property type="nucleotide sequence ID" value="XM_003858872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8U9"/>
    <dbReference type="SMR" id="A0A3Q8I8U9"/>
    <dbReference type="GeneID" id="13392235"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1200"/>
    <dbReference type="OMA" id="SRAMKMM"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZC3H15/TMA46 family C-terminal" evidence="5">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP52605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="221" mass="25878" checksum="B622AF96870BEEE5" modified="2019-04-10" version="1">MGKAEQKKKEKIVEDKTFGLKNKNRSAKVQAYVQQVKQSVDQRNPQDRKSQAELAARRAAKEEKRAREAELAKLFNDVDQQQRKKRDAEAAETAEGDDQYMCHPEEYLFRPEDFDEVEQDDERLEEKLEAEREKLKDRTDLTPVTEASFQAWKQRKREEAAEKEAARVRRAKSGDGKLRGWDLWQMDQELFVDDENADEFYEREELEGLDAGEDEAAFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9G7</accession>
    <name>A0A3Q8I9G7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160016300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9G7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1370"/>
    <dbReference type="OrthoDB" id="264183at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35416" checksum="A34CFFD7C1FC858D" modified="2019-04-10" version="1">MAHLGGHTTKQTYATTYTTDIDPRMLPDFVTRGAVPAEGWRGDETTGERQTSAKYASQPPCGQERHHHPPRHPYNPRPPHHGGAPPYDHGYRQQPPASHHDEYGCSEASASTSSATTSATSSASRADNGSSHRLRKKYTTTTVTTITTTTILLPKVQEAYVFPSVTSHHTDQQQNVGGAGGPYAITGGGTREYVQPPQGCLYEVGNGSDSSGRIQEANFPAGNRVVPSKMQPALSGEGSQNWEFRQHTKNQVETEEARGRLPTLQDLGIASYFAKDSTGNGSAVPRRREAPYAPAPHNPSNGAAPLRQQPWVAAETRYEVEGGKRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9R6</accession>
    <name>A0A3Q8I9R6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_130019000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1640"/>
    <dbReference type="OrthoDB" id="273507at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1288" mass="137556" checksum="0A6CC7BAEE93AA5C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB14</accession>
    <accession>E9BDU0</accession>
    <name>A0A3Q8IB14_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_3025</name>
        <name evidence="9" type="ORF">LDBPK_181100</name>
        <name evidence="8" type="ORF">LdCL_180016200</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860123.1">
        <property type="nucleotide sequence ID" value="XM_003860075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB14"/>
    <dbReference type="GeneID" id="13393438"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1400"/>
    <dbReference type="OMA" id="NCGRPLD"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000021">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="280"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="631" mass="70820" checksum="3029146C08EA7099" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICP6</accession>
    <accession>E9BI13</accession>
    <name>A0A3Q8ICP6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lsm7p protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Lsm7p_protein_putative/GeneDB:LmjF.26.0005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_260010</name>
        <name evidence="4" type="ORF">LdCL_260005000</name>
        <name evidence="5" type="ORF">LDHU3_26.0010</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861589.1">
        <property type="nucleotide sequence ID" value="XM_003861541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICP6"/>
    <dbReference type="GeneID" id="13389116"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0010"/>
    <dbReference type="OMA" id="FDNNVNL"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000094">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10062" checksum="26D7549A2265F8C0" modified="2019-04-10" version="1">MSAEAAHILKKKEGILSLEKYLDRKVVVSQKNHEVHGVLKGFDNNVNLVLADAELWHRNTHIRKIGACVVRGGPVNLILSGDTTIIPNPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICQ9</accession>
    <name>A0A3Q8ICQ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120019200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICQ9"/>
    <dbReference type="SMR" id="A0A3Q8ICQ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1440"/>
    <dbReference type="OrthoDB" id="258354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="384" mass="41342" checksum="660D2BF4055041C5" modified="2019-04-10" version="1">MSAASKSIDVMLKPLLVGGRPISNRFVMAPLTRCRADDNHVPTAAMVKHYSDRASMGLIITEATQIQKGYSTFAHEGGIYDKEHVDGWRKVTDAVHDKGGIIFCQIHNGGRSTVPSNVDEGVRIVAPSAVAITGHKCAGSFARNGKTQPYPVPHAMAAEEIASYVSLYAAAARNAIAAGFDGVEVHGANGYLIDQFLKTSSNQRMDEYGGSIENRCRFLFEVLDAVIQAIGRERVGLRISPLNSFNDQSDEDPQALTRYICSQLNLRTIAFLDVMRGDFFSPARGADKWAREEYEGVLFTGMGFEIEEAAKAVESGAADAVVFGTKALANPDLVARAVAGAPLNKPDPATFYTNGEAGYNDYPFMERSPCLPASPSGAQEAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICS5</accession>
    <name>A0A3Q8ICS5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240010000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICS5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0630"/>
    <dbReference type="OrthoDB" id="266132at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="777" mass="83932" checksum="0E191571D9D52F60" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICW6</accession>
    <name>A0A3Q8ICW6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130014600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICW6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1140"/>
    <dbReference type="OrthoDB" id="267637at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="366" mass="38445" checksum="5973DFAE664033DA" modified="2019-04-10" version="1">MKSTRTTAKVRSACLPYSTTIRSSRQTSSLLSRVAHSVGAVVAKVNRLRQPPSREAHSPSGLAEGLLSSSSSAKPPVLASGAILRDLAFFTQASEVSFFCTGPLLCAQVFGVAPGDVFEVGGGRAVTSSSDVDAEAGSRIAGEAIVVVGTRSGRLWVWAYGDEAARVLRVPSSTTPAILSSAAEVRAALVEHYQLRQLAHPSHRQCSAGGGKAREQDAEAELVRTVREAFQSLCARAHEEVQRLYTPDQLAFLQRAPDLYAAVTKRVDWVASSSDAVSLAVGVNSEPQRQQPDHPPEMSSSVLPRSIYSDIARHAQHATAVVLLAPRVSLVTGAVGWVGEGDVVLAESLGGQGGCSEASLSVSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDB7</accession>
    <accession>E9BE84</accession>
    <name>A0A3Q8IDB7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_19120</name>
        <name evidence="3" type="ORF">LDBPK_190910</name>
        <name evidence="2" type="ORF">LdCL_190014500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860267.1">
        <property type="nucleotide sequence ID" value="XM_003860219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDB7"/>
    <dbReference type="SMR" id="A0A3Q8IDB7"/>
    <dbReference type="GeneID" id="13386079"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1110"/>
    <dbReference type="OMA" id="FIHFYIG"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000011">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF36">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="112" mass="12520" checksum="05781C87EFC262B9" modified="2019-04-10" version="1">MSGTRVLIKESAMPVDMQQDCADCAAHALFTLKLREQTDLAQFIKKELDVKYGGQWHCIVGHSFGSCVGHDEAYFIYFEINGIFFSMWRMDVTLEAKQVPINSAGRTVPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDK5</accession>
    <accession>E9BEL4</accession>
    <name>A0A3Q8IDK5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA uridylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_200670</name>
        <name evidence="5" type="ORF">LdCL_200011400</name>
        <name evidence="6" type="ORF">LDHU3_20.0810</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="1"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860407.1">
        <property type="nucleotide sequence ID" value="XM_003860359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDK5"/>
    <dbReference type="SMR" id="A0A3Q8IDK5"/>
    <dbReference type="GeneID" id="13386194"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0810"/>
    <dbReference type="OMA" id="GAYIHLV"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000035">
        <property type="entry name" value="Mitochondrial editosome-like complex associated TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000069">
        <property type="entry name" value="Mitochondrial editosome-like complex associated TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF97">
        <property type="entry name" value="MITOCHONDRIAL EDITOSOME-LIKE COMPLEX ASSOCIATED TUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="4">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="406" mass="46186" checksum="65E23BBE74B2C2A1" modified="2019-04-10" version="1">MQAGRRKFVAESIAAYRASQGTSNDKEVVDDLRWRVVDLCSRCVNKVELQLFGSLATGFCTTGADADLSLTFRNFSPWLSGIEVVDAQNFKRLARVGREAGEMGMENVRLINARIPVLQFQDAISGIRCDLTIGNLGGVANSKILAEIHRVLPDFYGAYVYLVKEWAKKCEVVAPDKSMFNSFTMTTMSLMVLQELGLLPIFVPTGTYGELTLPDVRNALDTFQLPPVYEGIGQDDERLGEAVYFCLLRFAEYYSKFDFRNGTVSLMCPRRHRSLYAQIVKQHIELLGERKRKEWSAYLLGDRAASTSSSRFPQVSFEESMRHEALQRQADTAFVVEDFVNYVNCGRRVPPGRCSKIHLEFKRLYEQLRDEANVSFRDVFHETHAIPLTHKPNRPDSRVETFETKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDX2</accession>
    <accession>E9BJU9</accession>
    <name>A0A3Q8IDX2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_282280</name>
        <name evidence="2" type="ORF">LdCL_280027900</name>
        <name evidence="3" type="ORF">LDHU3_28.3110</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862327.1">
        <property type="nucleotide sequence ID" value="XM_003862279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDX2"/>
    <dbReference type="SMR" id="A0A3Q8IDX2"/>
    <dbReference type="GeneID" id="13387063"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3110"/>
    <dbReference type="OMA" id="PKMQIHA"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000015">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10231" checksum="B4DE2216F42485D7" modified="2019-04-10" version="1">MTQVPGATVKLSEMPKEMENFAIFCAQEGLAKLRTAQELASFIRKEFEKKYGPTWNCFVGRNFGSFVTHEEGNYVYFYVGQTGVLLFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEG9</accession>
    <name>A0A3Q8IEG9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_190011000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEG9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0670"/>
    <dbReference type="OrthoDB" id="267825at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="777" mass="79477" checksum="776D0B98741087FA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEH6</accession>
    <name>A0A3Q8IEH6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dpy-30 motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270025900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2850"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1521" mass="162671" checksum="11BA02760FF8EB91" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK7</accession>
    <name>A0A3Q8IEK7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial RNA binding protein 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Mitochondrial_RNA_binding_protein_1_putative/Gene DB:LmjF.30.0260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_300007700</name>
        <name evidence="9" type="ORF">LDHU3_30.0400</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0400"/>
    <dbReference type="OrthoDB" id="5803930at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5432044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="641" mass="68624" checksum="2CB37A3F995EDF0E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF78</accession>
    <name>A0A3Q8IF78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250013200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF78"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1000"/>
    <dbReference type="OrthoDB" id="264345at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="354" mass="37487" checksum="EA934744A10C2692" modified="2019-04-10" version="1">MDCLSEPSFLLRHIRRCGADEPKQTSQQATASTTGASSDSSYTTEVLLKVGVPASFAPADGSSGTASPTQVCYMCPAYILQAGCPALRELLADAFGDDPGGVRGVGEKAGANSAAAAANSAAAAALRPSPPVAVPLPFLDKGVFDVVAVYLEHFHALDYTTSASIAAAAAHSSPTFLSSPARVPSSLERPLNFQDLYALSTWEHYYVLCQLLGLERSQVDSLRLVECGAWVDLLGGAAAVPLPKGETQKQQRQVTVAHEVELSQQRAECFSLANRRRMWSRLCHVLGAASRLGMPTLRFLCATVAADMLVDLDEAGLARLMQPSGDGGRGSGIPPFTAQARAQVLERFPWLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF95</accession>
    <accession>E9BFH8</accession>
    <name>A0A3Q8IF95_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_211920</name>
        <name evidence="7" type="ORF">LdCL_210024900</name>
        <name evidence="8" type="ORF">LDHU3_21.2300</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860709.1">
        <property type="nucleotide sequence ID" value="XM_003860661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF95"/>
    <dbReference type="GeneID" id="13386540"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2300"/>
    <dbReference type="OMA" id="AAKPTEC"/>
    <dbReference type="OrthoDB" id="264511at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF157">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="631" mass="69011" checksum="83E991D1DC290DFA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFD5</accession>
    <name>A0A3Q8IFD5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310024200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFD5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2950"/>
    <dbReference type="OrthoDB" id="271314at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30249" checksum="9AB730A9C944AB4A" modified="2019-04-10" version="1">MPSVPTCQHGSYHQCECYGHNTQLPNYRHDISNPRTLQGYYAPNGGCPCPGTCGAEKNGLYCSGRGADASAMPKLTFRAADGPHTVHTAADADGNGRDPATSIRTAFPNSRNYGGTVAQRGPATLSTRAQLGASRKARAEAKREERAQDRKNFLRGVLRDEMLARMDAEGKRAALEADMGLMGTHHGEEYEASQRVAGSMRGGLDSTSRDPDTVLTLGEQYRDIMDELEYVADQPVGSKYNIIRLHYLVEEEDRLSRLRLQERIQKTAEAMQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFN0</accession>
    <name>A0A3Q8IFN0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310027300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFN0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3510"/>
    <dbReference type="OrthoDB" id="267139at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="849" mass="91302" checksum="AA0212AC58C4754F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFQ2</accession>
    <name>A0A3Q8IFQ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine O-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340035100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="2"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFQ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340035100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4650"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000015">
        <property type="entry name" value="Serine acetyltransferase, plasmid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="entry name" value="serine acetyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42811">
        <property type="entry name" value="SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="411" mass="45131" checksum="589B7962C3C35DF0" modified="2019-04-10" version="1">MKRLDRIREALEQLNPQRADSALPTFHPRISLHKLKELVECLFYVFFPECTNPPSEVTPTFAEADALMEWVIGHIADILMTQIYVAFVLHGDAHAVEDTKPFKPLNTSQRTQLEWNGQRCATLSLLAMESTCTKGGCGVAAAAEKDVSKAATEKLRCTGNRARLPSTEVSSKSSTPKANAMCETADINSGANQAFLTNCKRRADAIVTKFVVERLAHVRWLLHTDVEAIFEGDVAASSPSEVVLCYPGLRCMVHQRVAHQLHLLGVPQNLTRMLTELAHSETGIDIHPNTAIGHHFFIDHGTGVVIGATAIIGNGVSIYQGVTLGARSFPTDEKTGERIRDLPRHPIIEDGVTLYANAVVLGRVTIGERSTIGGNCWVVRDVPPFSSIVQRSHHVLQPHERMFLERDGSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFV1</accession>
    <name>A0A3Q8IFV1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300024600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFV1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2660"/>
    <dbReference type="OrthoDB" id="262000at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1165" mass="124106" checksum="FDDD66989B222609" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFX0</accession>
    <accession>E9BIH1</accession>
    <name>A0A3Q8IFX0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_261590</name>
        <name evidence="7" type="ORF">LdCL_260021600</name>
        <name evidence="8" type="ORF">LDHU3_26.2010</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861745.1">
        <property type="nucleotide sequence ID" value="XM_003861697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFX0"/>
    <dbReference type="GeneID" id="13388992"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2010"/>
    <dbReference type="OMA" id="GPLKKYH"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000025">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="303"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="561" mass="63740" checksum="7A2963EB6FE97AFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG49</accession>
    <name>A0A3Q8IG49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350019500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1910"/>
    <dbReference type="OrthoDB" id="265554at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF66">
        <property type="entry name" value="CARD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2539"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2175"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2737"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2911"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3092"/>
            <end position="3130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3300"/>
            <end position="3327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2542"/>
            <end position="2555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3373" mass="359002" checksum="8C417CB9BD73C978" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG69</accession>
    <name>A0A3Q8IG69_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_28560</name>
        <name evidence="1" type="ORF">LdCL_360034500</name>
        <name evidence="2" type="ORF">LDHU3_36.3910</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG69"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3910"/>
    <dbReference type="OrthoDB" id="244954at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112117" checksum="F1B7D8DB34E0CCB6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG95</accession>
    <accession>E9BJ00</accession>
    <name>A0A3Q8IG95_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6 9">Glutaredoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glutaredoxin-like_protein/GeneDB:LmjF.27.0810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_32970</name>
        <name evidence="10" type="ORF">CGC21_31060</name>
        <name evidence="8" type="ORF">LDBPK_270670</name>
        <name evidence="6" type="ORF">LdCL_270013200</name>
        <name evidence="7" type="ORF">LDHU3_27.1050</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861923.1">
        <property type="nucleotide sequence ID" value="XM_003861875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG95"/>
    <dbReference type="SMR" id="A0A3Q8IG95"/>
    <dbReference type="GeneID" id="13389183"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1050"/>
    <dbReference type="OMA" id="DSTHAQF"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000384">
        <property type="entry name" value="Glutaredoxin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP46110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP47570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="108" mass="12127" checksum="E0CA64DFC9F246F6" modified="2019-04-10" version="1">MLSSRFLYRPSTMPATVAELIHRHKVVVFSWVHCPYCSRAKEILKSLAKDIQVYECDQMDNGEELRAQILQAYNHDTVPAIFINGEFIGGCSDLQAIQKSGELAAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGC8</accession>
    <accession>E9BN39</accession>
    <name>A0A3Q8IGC8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CrcB-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">CrcB-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_10945</name>
        <name evidence="12" type="ORF">LDBPK_312690</name>
        <name evidence="11" type="ORF">LdCL_310034900</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863356.1">
        <property type="nucleotide sequence ID" value="XM_003863308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGC8"/>
    <dbReference type="GeneID" id="13389688"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4770"/>
    <dbReference type="OMA" id="CAAQFPL"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ36667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="392" mass="41567" checksum="4B55D5F26F4AB633" modified="2019-04-10" version="1">MNRCSLRQQGARLDTVKPVKQAFPADVPPAAHSPAGAPDGHGTVFSHHDGEAHNDTARRDEQASYSSQSPLPPAPSAVTPYTGNWPPYALLLVSCLIVAAAGLGGSAARVALQKCFEKSPFFPKYNYIGPNILGSFLMGFSVTVLPPEAALPLTYRALCVGFCGSFTTFSSWIVKVMVQNTVADAFEHLLIGGTMPLVFFLWGRDCGRGVRWCCAHVVGSPWETWPLHCSLLRAVDAVVLVLVVLASVLSPVLVLVYISEGGIRAISADDVRVVALAPAGAVTRFVLSVCLNKRACAAQFPLGTLAANLLGVLLAVVMCNMEVNHLSCEWCIVVRNGIGGALSTVSSVANELVSFYGSGRMPLAYVYALVSVGFSVFIAGVGRPQLHRRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGJ2</accession>
    <name>A0A3Q8IGJ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320008800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGJ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0480"/>
    <dbReference type="OrthoDB" id="266803at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="671" mass="73913" checksum="BE73506250DEC78B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGW0</accession>
    <name>A0A3Q8IGW0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Elongation factor 1-gamma, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_330022900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGW0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2470"/>
    <dbReference type="OrthoDB" id="269973at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000069">
        <property type="entry name" value="Putative elongation factor 1-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF9">
        <property type="entry name" value="FACTOR 1 GAMMA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24235" checksum="0FFF36D5FDBFDF89" modified="2019-04-10" version="1">MHLLYKKNANNAPAQKILAAAAYAGVEITAEPCDENKASTDADFLNFCDPCGEYPVLEPGDGSGVCVFGANAILRYVARMKNEGSVHPYGRTPFEASQVDMWIDFSSTEIDAANMPYIRMAYEKATSDAPADALDKVKAVLSALEEVLSVRTFLVGERLSIADVAVAFSIHLVYRCNRKHGQTLSKEYRAVYRHYNTVMRHPKVHAMMRKEGAALGPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH03</accession>
    <name>A0A3Q8IH03_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320024300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH03"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2370"/>
    <dbReference type="OrthoDB" id="268051at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25175" checksum="DED95BAA0C0ED8C0" modified="2019-04-10" version="1">MRGNLYSRGFDPMKSRSERRKEKQAKLAKTKRVIRLKKRLGRIAARKFAVQEDSHMTALMESYILRRKAERAAEKAKDAPKDGAEASGEGGLAGKGSGAEESEMDEDEGSDSSSLGSRANSAFDVDDVDEEEEEQEDIASSRRRAVQCRQAGYARGGGGACLAANKDSTAPGGKHGRGGGAGRRGQGIRGFRSAQRGGRGSARGGRSSHNRQNTSRNGSFHERSRKVPTRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHA0</accession>
    <accession>E9BR10</accession>
    <name>A0A3Q8IHA0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_26355</name>
        <name evidence="2" type="ORF">LDBPK_342120</name>
        <name evidence="1" type="ORF">LdCL_340028900</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864371.1">
        <property type="nucleotide sequence ID" value="XM_003864323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHA0"/>
    <dbReference type="GeneID" id="13392780"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3550"/>
    <dbReference type="OMA" id="WEWENRA"/>
    <dbReference type="OrthoDB" id="261736at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="206" mass="23416" checksum="CB3CC9D190115658" modified="2019-04-10" version="1">MSHIHHTYHGRAGSSITTLSCSSLAAQGSEKQRQYGQRCALLREERYRRGSICALENNEWAELSIVCADELAVEWWREDARKSNNAGPTEPRPTRYTYRYRAGTTVSVLPVGQSTEALNGSLTAAVGTVNAEENQLRLWEWENRADLQEWELGERQEMAQAMQSILVAQRELELAHLEAACRRVMNGTTALDWTSYPRYDRPELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHC1</accession>
    <accession>E9BIT2</accession>
    <name>A0A3Q8IHC1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32625</name>
        <name evidence="3" type="ORF">LDBPK_262710</name>
        <name evidence="2" type="ORF">LdCL_260033100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861855.1">
        <property type="nucleotide sequence ID" value="XM_003861807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHC1"/>
    <dbReference type="GeneID" id="13389103"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260033100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3540"/>
    <dbReference type="OMA" id="DCRTQSF"/>
    <dbReference type="OrthoDB" id="260026at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599603" evidence="1">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="377" mass="40868" checksum="288F0637B5A98C71" modified="2019-04-10" version="1">MISQCFYLAALITTAMTITTSNVTFYQEGLSTRIDGTPTVVRNIAPDWIETAAMTVSSTTKELAVVLADPLRAHMTADVTIGDSATAVAADVNVSIYGAFNISKIPHDEDCNTQSFVMNSCHVYMRVSGTVDTVAQLPADEQNICDAVSQITHDLITPVAFIPYPPVVDGATDIAKSTYLMKYRLVNVLSENTGLPVEAHFVRKNVLRVAFGSFVRTSILFDSAYDYDVDVLNAMAVLSRWATKKLNISIDPENSTTTRIPFHGGAVTVPTLRSIVRQAIHEDALATLRTLVPRGASVSYDVVINDFQCKLFNTICSVPVSNGVQVINTRFRGMGDLGTILDNTASASMDALLTNITTVAFKLVGSTFGDRIYLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIP6</accession>
    <name>A0A3Q8IIP6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350047200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIP6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350047200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5430"/>
    <dbReference type="OrthoDB" id="272182at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33425" checksum="D034CEF58191BCD6" modified="2019-04-10" version="1">MFDSLRLLVLSFLYYLGFTYAAFAALKQRSTTVVTAGPPAPSPATANAPRPGTKVEIGVPALKLMIMLTTMALLSLVGADWFPLFAEMRVIFMYTLLYAPPLAQQELYDQLFAPLLVRGGALALSPQTRDVVARTLSLFVVRRCIDVAIAAMNYTECSRILGADAARDILSSLQFCQRALQQTAAITRESGRATYAQIARDRNFAVGAFTSHVRRALMSRKEREDFSARIPLGRVVRDEHVDPESGLPVATASLWATSSFSSTTRDGLVGSLHDEYSHSGLESGEGGRTDCLRRGVDHRAKLSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ17</accession>
    <name>A0A3Q8IJ17_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spermidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160013400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ17"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160013400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0980"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000561">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="66441" checksum="5AEB79A1B7FAE201" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJI3</accession>
    <accession>E9BSF0</accession>
    <name>A0A3Q8IJI3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_6880</name>
        <name evidence="4" type="ORF">LDBPK_352800</name>
        <name evidence="3" type="ORF">LdCL_350032900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864859.1">
        <property type="nucleotide sequence ID" value="XM_003864811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJI3"/>
    <dbReference type="GeneID" id="13387737"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3560"/>
    <dbReference type="OMA" id="GAMHELQ"/>
    <dbReference type="OrthoDB" id="273268at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="591" mass="65215" checksum="7203AC53EEFED41C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJR8</accession>
    <name>A0A3Q8IJR8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING-variant domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_310005200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJR8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0050"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="986"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1052" mass="115270" checksum="09AD4E98B37407F9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKT1</accession>
    <accession>E9BQP6</accession>
    <name>A0A3Q8IKT1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_2075</name>
        <name evidence="14" type="ORF">CGC21_25810</name>
        <name evidence="13" type="ORF">LDBPK_340940</name>
        <name evidence="11" type="ORF">LdCL_340014900</name>
        <name evidence="12" type="ORF">LDHU3_34.1490</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864257.1">
        <property type="nucleotide sequence ID" value="XM_003864209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKT1"/>
    <dbReference type="GeneID" id="13392666"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1490"/>
    <dbReference type="OMA" id="DEMEADY"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000005">
        <property type="entry name" value="Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5433653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP40008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP50441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="159" mass="17477" checksum="FD67F1381DC3F4CF" modified="2019-04-10" version="1">MSDHEDEDDLLSLNLGGDRDEGDSGSDIRHSGADEEDEEGGEQLPEDVAANVILSGNAQAAKGARARGINERVTSAVMTKYERARVLGTRALQISMNAPVAVALEGETDPLTIAVKELRERRTPLIIRRVLPDNTYEDWSVSELLVDFDRPADERYTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILB9</accession>
    <accession>E9BUF5</accession>
    <name>A0A3Q8ILB9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14515</name>
        <name evidence="3" type="ORF">LDBPK_364470</name>
        <name evidence="2" type="ORF">LdCL_360051900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865561.1">
        <property type="nucleotide sequence ID" value="XM_003865513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILB9"/>
    <dbReference type="GeneID" id="13388447"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360051900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6080"/>
    <dbReference type="OMA" id="HSWNARI"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47026:SF2">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47026">
        <property type="entry name" value="PIGMENTOSA GTPASE REGULATOR-LIKE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="431" mass="48829" checksum="E35338507B93881D" modified="2019-04-10" version="1">MNSTTTISTDPDASFSRAASRVSTPGTMSVLVPYKRPGQKSSMAPGGASQQQRSLQSAYAGKSIRTSASTLSSSVPPHGAGAASRGDQSRRGNGAPDGTLNSYSSHPAAPLDRPRDEEFDAVERRARMALESIATRDEDLEPSMGDHIEVLQSYRTACEARAMYREAYLVQQVLRNLRLEEESRHVRGITEQQMEERRILEEAHRQEFREFHHSWNARIDAFEEEQLDAELALLERQNEELIRFQEEMRNFQPRLLRYSRSLLESRLKQQTLAKQRDYVAAQAQKAHAEAIEVGDIERFEAARMSLFERREYAARHRHQQELYALRTKVESRRLYLERYRKQELDVLLQRYINARRSMESQQNIVRNKTGTLLLKHACNMKTDNSGTAVLVESAGSGAFGTMVQRRQACELRASQGPPDGASASVHDGSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILF1</accession>
    <name>A0A3Q8ILF1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PSP1 C-terminal conserved region containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360055000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILF1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360055000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6450"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF21">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="3">
        <location>
            <begin position="496"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="584" mass="62415" checksum="2BA748DEBC5BC6DE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILI6</accession>
    <name>A0A3Q8ILI6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_320038900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320038900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4160"/>
    <dbReference type="OrthoDB" id="267734at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="1206"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1343"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1305"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1484"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1511" mass="159477" checksum="8D0F0187D756D011" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INI0</accession>
    <name>A0A3Q8INI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S19 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_340033800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INI0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340033800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4270"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000593">
        <property type="entry name" value="40S ribosomal protein S19 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20163" checksum="8278DEB1DBF345E5" modified="2019-04-10" version="1">MYSPARMSFIRRVTNPSCIMASLKNKIHRIGKRKGASLKDVSAWRWIKTAARHFKQEGKIFVPNCTEIMKSSHGRERAPQNPDWYYIRCAAVLRAIYLRPGVGYGGLSKRFGNKKNYGSRPEHTVTSSTGPLHWACKSLTKLGLVEPGAQSGQRLTRKGHKFADSLAFQVQIRKFGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INJ9</accession>
    <accession>E9BTM2</accession>
    <name>A0A3Q8INJ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_13130</name>
        <name evidence="4" type="ORF">LDBPK_361630</name>
        <name evidence="3" type="ORF">LdCL_360021800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865278.1">
        <property type="nucleotide sequence ID" value="XM_003865230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INJ9"/>
    <dbReference type="GeneID" id="13388164"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2120"/>
    <dbReference type="OMA" id="DRDFHQD"/>
    <dbReference type="OrthoDB" id="265288at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="476" mass="52961" checksum="9B4698521130DFD9" modified="2019-04-10" version="1">MSATQSMAESGVSSLQRSGLSITVGDTKSIVLALQALQSKIRSLEQDRDFHQDQYEVALQAHERYKLDMERQMEQERAAHRKREADLLELLRRAREERAQLEDTLSGNKEDLGGFRRELEQMIASEKELASQRESKINMEVAKLRSEIKEEQTHRAALLVTVEKLKEEREAALKTNEQLRIAMDGLLTRYEQLQRRRPAPQAVPRRYPSSGVSCETHSRAAPATGAHPRRSVSGRTRSLGYAPPRELQRSALPARQRKVSPSLHHNYEDPTCNSILRDVRIVPEEAPPCAYPSANSSMHHSQQEAAETTGKAIAARSGQGLRAQATAAPSRSGRPSPARRPPETGVAGPSAHRTTAIDEVEAQLRQELEELQHRYDDTIERGSSEEVPREVLAAALHRISALLEQKKEQLKLLKEARMELEEAVSFSASRSTNTNWSMNGGGGGSPSTLAMQDKHTRRALLVNELRSLLAEAAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPT0</accession>
    <name>A0A3Q8IPT0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CGC21_31115</name>
        <name evidence="1" type="ORF">LdCL_270012100</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPT0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0920"/>
    <dbReference type="OrthoDB" id="272756at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TPP47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="450" mass="48770" checksum="C018D66E4D8F3812" modified="2019-04-10" version="1">MRLRNPCGVKGIAADALVDLVQGCYPSATVLFTSVASSAATADNSEVRISSSFDAWQAKLHTRRAWRQGLTVETPGFQRILARRHIVPATWAEAGASSWWALLYAADATNSPPVALPQQPSKSLPPSDIAHPILCCPDAIVYIGGVEVRDVTQVVAPMLVNAVTRVEAPRSTVGAASATHRAERQAPSYCRRSVDWPTIWADKRCAMRGADLLELSLAVPSGVDHRHADARERMLVSIANPDVTLADLQRQRHAERRGPLRTSFGFSLPCIQAALPAAVIRAVRVLRRWQQDVVHCIPSTSAFWVSSIGHLLETSVGDAASPLTQRAEACTRQEQELGMSETQVRHLFAIVQPDSDQTKIRVPPPGEATKLLTFLLTSTVLQLACTSPLEAWNGINYFLPAERFDGTTDAEVLLRTMRGGAGTHLTFPIFSTLYGASCGEEQGPLSQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H544</accession>
    <name>A0A3S5H544_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030009800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H544"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0490"/>
    <dbReference type="OrthoDB" id="267178at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1024" mass="108187" checksum="5EE749B69F98230F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6D1</accession>
    <name>A0A3S5H6D1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090010000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6D1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0620"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21341">
        <property type="entry name" value="TTC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002668">
        <property type="entry name" value="TPR Domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="568" mass="61445" checksum="709194FD32BF3251" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Y1</accession>
    <name>A0A3S5H6Y1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_160015400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Y1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1240"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="3">
        <location>
            <begin position="530"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="944" mass="102236" checksum="11CA3A63C3E2FDB8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Y3</accession>
    <name>A0A3S5H6Y3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosyl or methionyl-tRNA synthetase-like protein</fullName>
            <ecNumber evidence="5">6.1.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tyrosyl_or_methionyl-tRNA_synthetase-like_protein /GeneDB:LmjF.16.1130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_160016800</name>
        <name evidence="6" type="ORF">LDHU3_16.1440</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Y3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1440"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000442">
        <property type="entry name" value="Tyrosyl or methionyl-tRNA synthetase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5428977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19598" checksum="D7EDECCE6E88C3F1" modified="2019-04-10" version="1">MSRCCFAVGKVLEVSRHPESEKLYIEKIDLGAELNMLSNNEPRTILSGLQEFVKEEDFVNRLVLVIANLEPRKIGGIPSAGMVLCASTGEDPHDPALAGQGERKVVLLDIPEGTAVGERVVFEGHDMPYEPVLKKKLAKNFEEVMKDVCSSADGVVCWQGKPFQTSAGVIKASLCNARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7H7</accession>
    <name>A0A3S5H7H7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinoic acid induced 16-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270016900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7H7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1660"/>
    <dbReference type="OrthoDB" id="272562at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="986" mass="106371" checksum="1815D29EEA1F7984" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7J3</accession>
    <accession>E9BJM7</accession>
    <name>A0A3S5H7J3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_281560</name>
        <name evidence="2" type="ORF">LdCL_280020300</name>
        <name evidence="3" type="ORF">LDHU3_28.2010</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862255.1">
        <property type="nucleotide sequence ID" value="XM_003862207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7J3"/>
    <dbReference type="GeneID" id="13386991"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2010"/>
    <dbReference type="OMA" id="DVTHYAT"/>
    <dbReference type="OrthoDB" id="242919at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="725" mass="80190" checksum="50B8B5031ED009C9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7R1</accession>
    <accession>E9BNC9</accession>
    <name>A0A3S5H7R1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_320240</name>
        <name evidence="9" type="ORF">LdCL_320007300</name>
        <name evidence="10" type="ORF">LDHU3_32.0320</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863443.1">
        <property type="nucleotide sequence ID" value="XM_003863395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7R1"/>
    <dbReference type="SMR" id="A0A3S5H7R1"/>
    <dbReference type="GeneID" id="13390018"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0320"/>
    <dbReference type="OMA" id="THEKGHF"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5432780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10587" checksum="CFB776CA23DBF4F6" modified="2019-04-10" version="1">MYNNDHKATVKNADMPEDMQADAIEVTLQAMEKFNIEKDIAAYIKKEFDKKYQPTWHCIVGRNFGSFVTHDTHCFLYFYLGQVAVLLFKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP10</accession>
    <name>A0A3S7WP10_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_24425</name>
        <name evidence="2" type="ORF">LdCL_050008700</name>
        <name evidence="3" type="ORF">LDHU3_05.0420</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP10"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0420"/>
    <dbReference type="OrthoDB" id="273783at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="328" mass="34293" checksum="7BF9F8B515C0A790" modified="2019-05-08" version="1">MPSDRDPSGDGFNNPYANTTLVGNWLEDRLQQRIVHKRRGGAAATWCAQGIFEDPAVTMARHPAEAQAALLHSTYEVDYGHRLGMTQRTGSGGMDNSAAVSTLMRGSRHNANAAGPGSGSSTAKGGIDKVLLFSVDPVADPAAPLPLSTNADTYGAFYYETGDGSVDVNGARYAGSSTGATTSSPADRGDGGATAPPAGADRNLYDSVSRAVAAAAAPSSSFRMPRAQMQRGANADATSSSLPVPRRHMLSRGVATTSTFGHTGWTLASSSATSAAGHVSAAPWRPPQRHRPPNKDSMDGERWCSSKQAADTPVEHFTLQQRLPPVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ87</accession>
    <name>A0A3S7WQ87_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_080010800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ87"/>
    <dbReference type="SMR" id="A0A3S7WQ87"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0650"/>
    <dbReference type="OrthoDB" id="266673at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19283" checksum="A202CBAD67EDB087" modified="2019-05-08" version="1">MTTPWATMVVAQGSASAVTGICSYAVWTTTLPPSGDAHIVYPPGAVAYQPQNHTIQPVNFFLHHWYVAIALILCAVCGFYTSLALSFIHHFDFYAQHQAMKVVGESYATKGYFNLDGEDAHGAPRPTAALAGAHAARSRRLSLSSVQSSSYSDDSYDGESLPSPSEADDGIIEMNPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQC1</accession>
    <name>A0A3S7WQC1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080013100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQC1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1040"/>
    <dbReference type="OrthoDB" id="265473at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21938" checksum="AC5FEFA42857B555" modified="2019-05-08" version="1">MACRIGMILYVIFQFLAFFLVLVGTPIDMFRVKELGRFANTPCLTLWGGKEECYSTMYDVSYEELWANCTHRRLQFRVAASLAVISIVVYGLAFILGFIALCCCFFFRWVCLTLNILGFGTLGVVWALMVVVYYKDDGLFCPRVSSRFDFGFGFILLVVAWCLNIIDIWFLVLPCTVGDSGARQSLSQDPKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQD0</accession>
    <name>A0A3S7WQD0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cysteine peptidase B (CPB)</fullName>
            <ecNumber evidence="13">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_080015300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="13"/>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQD0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1310"/>
    <dbReference type="OrthoDB" id="264239at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000212">
        <property type="entry name" value="Cathepsin L-like protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019092408" evidence="10">
        <location>
            <begin position="28"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="12">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="11">
        <location>
            <begin position="126"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="443" mass="48059" checksum="E907DA7970EC2D01" modified="2019-05-08" version="1">MATSRAALCAVAVVCVVLAAACAPARAIYVGTPAAALFEEFKRTYRRAYGTLAEEQQRLANFERNLELMREHQARNPHARFGITKFFDLSEAEFAARYLNGAAYFAAAKQHAGQHYRKARADLSAVPDAVDWREKGAVTPVKNQGACGSCWAFSAVGNIESQWARAGHGLVSLSEQQLVSCDDKDNGCNGGLMLQAFEWLLRHMYGIVFTEKSYPYTSGNGDVAECLNSSKLVPGARIDGYVMIPSNETVMAAWLAENGPIAIAVDASSFMSYQSGVLTSCAGDALNHGVLLVGYNKTGGVPYWVIKNSWGEDWGEKGYVRVAMWKNACLLSEYPVSAHVPRSLTPGPGTESEERAPKRVTVEQMMCTDMYCREGCKKSLLTANVCYKNGGGGSSMTKCGPQKVLMCSYSNPHCFGPGLCLETPDGKCAPYFLGSIMNTCQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQT0</accession>
    <name>A0A3S7WQT0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_36815</name>
        <name evidence="10" type="ORF">LdCL_090017900</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQT0"/>
    <dbReference type="SMR" id="A0A3S7WQT0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1370"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="47"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="479" mass="52593" checksum="FACEA5F88DBB1C59" modified="2019-05-08" version="1">MAEEDIADFTLDDEKVIDTDQGLAKQDFSKIDLDELNVDTFEVMSRQATINVGTIGHVAHGKSTVVKALSGVKTQKFHREAVMNITIHLGYANAKVYQCETCPRPTCYQTYPSSQPDSTPCPNCGETMTLKRHFSFVDCPGHDVLMATMLNGAAIMDAALLLIAANESFPQPQTLEHLKAVEIMKLRHLVVLQNKIDLVGEVKAHDQYRHVRAYLDNIALNVPIVPISAQLKRNVDYLLEYLLHIPMPVRQLKAPVRMTVVRSFDINKPGEGDIESLKGGVAGGTVTQGVIKVGQVVEIRPGLVRSRSSNEQGGRFTYSPLKTRTVTLKAENNVLQYAIPGGLIAVGTTLDPTLTRQDKMVGNMLGEEGTLPEVYCEIEVQYYLFSEMVGAKSKDGKSTAKRVQKLNVLESLQINVGTLTAGATVLNITQDPEIAKLELVTPVCCSTGEQVAISRMVDKTFRLIGWGTIRRGVPMKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRG7</accession>
    <name>A0A3S7WRG7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myotubularin-associated protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_110006600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRG7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0200"/>
    <dbReference type="OrthoDB" id="267648at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin-related 12-like C-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="717" mass="76598" checksum="0EB5EE496B1BDE84" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WST9</accession>
    <name>A0A3S7WST9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_140007800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WST9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0370"/>
    <dbReference type="OrthoDB" id="269582at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="963" mass="108540" checksum="389F2DD54780EF95" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVA0</accession>
    <name>A0A3S7WVA0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_190006600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0170"/>
    <dbReference type="OrthoDB" id="271480at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019127590" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1491" mass="156871" checksum="330B709B933B3841" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVL9</accession>
    <accession>E9BEE3</accession>
    <name>A0A3S7WVL9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Triose-phosphate Transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Triose-phosphate Transporter family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Triose-phosphate_Transporter_family_putative/Pfam:PF03151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_8580</name>
        <name evidence="11" type="ORF">CGC21_18845</name>
        <name evidence="9" type="ORF">LDBPK_191540</name>
        <name evidence="7" type="ORF">LdCL_190021200</name>
        <name evidence="8" type="ORF">LDHU3_19.1870</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860326.1">
        <property type="nucleotide sequence ID" value="XM_003860278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVL9"/>
    <dbReference type="SMR" id="A0A3S7WVL9"/>
    <dbReference type="GeneID" id="13386138"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1870"/>
    <dbReference type="OMA" id="WMVVNTL"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="321" mass="35925" checksum="9A412524A12B71E1" modified="2019-05-08" version="1">MSTEQARTLLYLALNAFSSIGIVYTNKVIFTRHGFSYGTLLTVIHFFITTLGLFICRMMGVFEPKRIPVLKILPLCVGFCGFVALNNVSLVYNTIGFYQLIKVLTTPMLVVIQTLFYQKTFSAKVKLSLTVTCIGVGLSTVNDTSANLAGTVVALSALLITCMYQIWVGTKQSEFHCDSFQLLYNQAPISCAMLMPMAYFADDLANKYYTPCWPTIIVIIFSGLLAFFVNISIFLVIGKTSPVTYNVLGHFKLCVILSLGFLWFGDQMNARIFLGIVITLFGVFWYTHLKMQEGEKEEDAKILAKHEEEHVSVGEGDEKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW94</accession>
    <name>A0A3S7WW94_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210007100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW94"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0230"/>
    <dbReference type="OrthoDB" id="272137at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="766" mass="82760" checksum="D7D443AC037FAC48" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWT8</accession>
    <accession>E9BFF4</accession>
    <name>A0A3S7WWT8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_22110</name>
        <name evidence="14" type="ORF">CGC21_34475</name>
        <name evidence="13" type="ORF">LDBPK_211680</name>
        <name evidence="11" type="ORF">LdCL_210022600</name>
        <name evidence="12" type="ORF">LDHU3_21.1990</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860685.1">
        <property type="nucleotide sequence ID" value="XM_003860637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWT8"/>
    <dbReference type="SMR" id="A0A3S7WWT8"/>
    <dbReference type="GeneID" id="13386458"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1990"/>
    <dbReference type="OMA" id="DLTHFFH"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000027">
        <property type="entry name" value="TAX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052320">
        <property type="entry name" value="Cytochrome_b5_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281:SF0">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5429903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP49387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP54629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="221" mass="25482" checksum="C62F1EF0F0F5D894" modified="2019-05-08" version="1">MSRFYTAKEVREHAFHDDAYVSLNGKVLDLTPLIAAYKEMPKFAHLTKPLVQVAGTDISHWWDAEANDLRSCVDPNSGMRTYAMPLGRVPHMPTIYPDSNIDLNYDVPWWKDPQYIIGALTSRTRRIRIVNTLTGDETTLEVCAEETLEELLRERYLSINAHARSYTWVRLDPDPRELDMSRTLEDNGIHDEADSFEDLGLNADYYIPAIHLYYNDDLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXH1</accession>
    <accession>E9BG37</accession>
    <name>A0A3S7WXH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine Rich repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_17610</name>
        <name evidence="3" type="ORF">LDBPK_230170</name>
        <name evidence="2" type="ORF">LdCL_230006600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860918.1">
        <property type="nucleotide sequence ID" value="XM_003860870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXH1"/>
    <dbReference type="GeneID" id="13389879"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0210"/>
    <dbReference type="OMA" id="IKNCGMK"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="366" mass="38917" checksum="7464AC5A75A3CE5A" modified="2019-05-08" version="1">MWAEAYRAACAEVSADVREDVSSSGSTGELIVRGNTFENFKNRVTDTDVQAILAALRVCPGMSALYLPYNSITSEGGVLLGKALGHQLDSIITLDVQYNSLGAEAGVAIAQGLQRNDSLCHVTLAGNPLGGRCGAALGEALRQNMNLAVLDLFNTDLGMKALVHICRSLEVNKGLSSLNIGRPLLHGVDELESVVNHLSIALQRNSTLEELHMAYFGLVDDCLQTLVLALCGSAVTTLCIKGNKLSQDAGQLLARLLDRRHDFRNLDVSCNRLRDAGAEALAKGVAHHPQLESLGLESCTIGEGGLVVLVESLKSCATVRRLTLWGNDVTPAVASALTATFCDLCELDHIDVGVVEQDGQVVAYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXI5</accession>
    <accession>E9BG62</accession>
    <name>A0A3S7WXI5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase subunit 10, putative</fullName>
            <ecNumber evidence="1">1.9.3.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cytochrome_c_oxidase_subunit_10_putative/GeneDB:L mjF.23.0370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_18375</name>
        <name evidence="4" type="ORF">CGC21_17480</name>
        <name evidence="3" type="ORF">LDBPK_230420</name>
        <name evidence="1" type="ORF">LdCL_230009700</name>
        <name evidence="2" type="ORF">LDHU3_23.0610</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860943.1">
        <property type="nucleotide sequence ID" value="XM_003860895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXI5"/>
    <dbReference type="GeneID" id="13389904"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0610"/>
    <dbReference type="OMA" id="IGDFRKM"/>
    <dbReference type="OrthoDB" id="268515at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="118" mass="14115" checksum="C5CBBB0769EDB276" modified="2019-05-08" version="1">MRRFTSRIAAFAAVPAAEQTRQLHFPISPPPIEIDYLDSDPLEFAVRTEARRWGFDDLQYMRELAFVRIKNNPSIGDFRNMTPEERRDLFWGSDRQDFFRYITLKLTGHPEHLYHRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY61</accession>
    <name>A0A3S7WY61_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240012200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY61"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0850"/>
    <dbReference type="OrthoDB" id="273561at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30087">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30087:SF0">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019368408" evidence="1">
        <location>
            <begin position="19"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="438" mass="47839" checksum="982294404FAD0C3E" modified="2019-05-08" version="1">MCAYASIIVVSAVPLCFCYRSHTNQSMTPVNAPRLSSLPLATAWWRQHGLADRLEGFRGCRQPTPHQRPLQRTADGGVSLAWAGLLAGTEQSLTPSTTTATDRPPDLPLILVSACLLSYPVTYRGTRTSLPASLRPTPLLFLTEVLFKELGLVQCVPVCPEVQWLGLPVPRVPLRLVRGSRDTDDARRGSGWAATQHSSSATLPSLSMSASDSVAIKDKREVRYLVESSAEDHILMRYDAPNDTFAEQLPPPQLHSAFLTQLLQGLKAVDGIILKSYSPSCGVRDARLYEEAVTSPPSSPCDQHACNDCECAGKPTSVSFTGRRPAASASAQRRFDLVDGFFTQQLRDFLASVHGVDGGQRADARCHSEAAAPVITCDRLLTDFYTEERLRQAPLAGKVKKRRVAGNASEAAPHLTSLDSFMESVLQHRDWRFSQGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYG8</accession>
    <name>A0A3S7WYG8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA/TS-N domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_240021600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYG8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2010"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="396" mass="42920" checksum="27A191F455CFE668" modified="2019-05-08" version="1">MILEGAPVTGLTLLISTVSSTMVRGQYTRYRNMAFAPDTLAAPLTCFALAKRLLLQSIPIGPLGISVMDIFLAINLLYQFRTLERRWGSNTYMAFLFTSAVLGVCTVQLFVTESGSKQLSIDAVRILSAAGTIVPLAALLTCYLREVPSRSTLAMRIPGTNLIISEKALTLLPLMKLVLSPSTQLQAQTFRRAAVEADVGVWTRLWLALVGAIFAIMSTRSHVVRWWLTVFTRYICRPLLRFLRPLTDVLFGPSFTVDHAKPRNARHHQGGNGSFQLGIGGARAGFDGADDAGVVDGGRYVVESLTGGDTLQEVRARMRARRHGAQQQQQGSRGGAVAAGAPAQARRRSPQEETARNEAIATIEAIGLRASRDEIIAALDMTGGNLEMAVQILLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZV5</accession>
    <name>A0A3S7WZV5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin/Glutathione S-transferase, N-terminal domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260020900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZV5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1920"/>
    <dbReference type="OrthoDB" id="423541at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000565">
        <property type="entry name" value="Glutaredoxin/Glutathione_S-transferase_-_N-terminal_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="397" mass="43004" checksum="D896F25081E7872D" modified="2019-05-08" version="1">MRFLAKAVTTSAVTLGVGAVALLYCQRARNPGAAAGTSELTKELSAKEFNGLQNAKRLKEALAPSHLPWTFHAQKARYTNLRELTTQISQETAAAKPPGGRAYTASSSDMKLIFYRLLGCPYCAKVEAVLRYHDVPFVEVRVDPLSGKGLPDRRYQLAPQLYLAPLAEHNSGGAEAAATDSNGVYLVDSAEIVSQLSGPLKYAADIVNPHVSATRDWITNHFHGASFAITNNSFRDAYATYTYVTPSNYQNFLYHVAGSAALSVLSRYKVQPRLIAKMECADGPATAAPTGAPASTDSNGLWMLSEASRRALAATVRFGAVEEWLRAELQTFLQRRPNGKVFHGGSSPDLADVEMYGVTRVVDQHPRLGAVVREGAFGEWQTAMQEKLNANTGSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZY7</accession>
    <name>A0A3S7WZY7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone acetyltransferase subunit NuA4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_260023400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZY7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2330"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="329" mass="34504" checksum="F68A7ADDB3F91048" modified="2019-05-08" version="1">MSRRQNGGSKSANPEQQLRQEAAIFLSPDVEHELAQILQRRESIERALQRMDVEVYDLETAFLKHCVSHGGSLFDGFGLERRDNAHRNPVAVLTPVATCASSIGGGGSAIAPLSFEATPGSSPSSLLLPTVANGEHARTYRVLSSFFGAGGASGGSNGSAATDLAVASHSPTSLKAAGSVASPSAAATVFQVGSKGSTAPAFHYRIHFFSPSERVFSACSVGALSRVEIAKSTLAGSRGEPTSSTWSTTAAAAGRGKGLGKRGRFSSGGDELRGGRSGTASLLSELDRRSNAPPSRRHQRYAKEEDDADDDDASENGSGDRRRRRRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X032</accession>
    <name>A0A3S7X032_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_260024600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X032"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2480"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1094"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1222" mass="134017" checksum="84F90C886D48574E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0B6</accession>
    <accession>E9BIU4</accession>
    <name>A0A3S7X0B6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Cytochrome p450-like protein</fullName>
            <ecNumber evidence="9">1.14.-.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cytochrome_p450-like_protein/GeneDB:LmjF.27.0090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_33300</name>
        <name evidence="13" type="ORF">CGC21_31390</name>
        <name evidence="11" type="ORF">LDBPK_270090</name>
        <name evidence="9" type="ORF">LdCL_270005800</name>
        <name evidence="10" type="ORF">LDHU3_27.0120</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861867.1">
        <property type="nucleotide sequence ID" value="XM_003861819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0B6"/>
    <dbReference type="SMR" id="A0A3S7X0B6"/>
    <dbReference type="GeneID" id="13389128"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0120"/>
    <dbReference type="OMA" id="WKHQRRT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000248">
        <property type="entry name" value="Cytochrome p450-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5431120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP47636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="592" mass="66747" checksum="2E4715D64B6CEF32" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0I2</accession>
    <name>A0A3S7X0I2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270012000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0I2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0900"/>
    <dbReference type="OrthoDB" id="272649at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37561:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="452" mass="48643" checksum="6C1832D38D9C545D" modified="2019-05-08" version="1">MQNSNSSYPSQKPYRGRGITDGPSMGTPHSTYSQQKPPTSPLVFAAPGSGTPPQQQDPLSASLYSEPLPMNYKAPLGRHNSRTLIEVEDSPIKVTCLTKGGTRSPYMTPMPSDMAPDADRSGRHNPYTFSYSGSSSPIQVSTPTHSPQASAFDSSAAASRRMQRSGPYGCTEPPLADARLVQGHSVRLDTTFALPPEVVHRALKDRCRYIQFPANLPVFPKAGTLGPNANNGNNSSSNGSTGSGGSGESSLPIALFIGQVRFETTAAELLWLVHRTCGACASHLESRGAGCYLLYCKSEADLTLVRSLHKRILFDIGGVWLARTADEVDAMCEYIALDAPLLSKKARLPRDSMVVEELKADAINSGGRRGHEKRAMSDHSISGNRRGGGRGASAQGSGVDDMSQTASGDARQQPMQQQQRRRDQEGLPTYEESAPPYPGYPPQSFGERPLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0K5</accession>
    <accession>E9BJ22</accession>
    <name>A0A3S7X0K5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_32875</name>
        <name evidence="7" type="ORF">CGC21_30965</name>
        <name evidence="5" type="ORF">LDBPK_270880</name>
        <name evidence="3" type="ORF">LdCL_270015400</name>
        <name evidence="4" type="ORF">LDHU3_27.1470</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861944.1">
        <property type="nucleotide sequence ID" value="XM_003861896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0K5"/>
    <dbReference type="GeneID" id="13389205"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1470"/>
    <dbReference type="OMA" id="NSNYWFY"/>
    <dbReference type="OrthoDB" id="276565at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="206" mass="22983" checksum="34A7FEDA4B8E1024" modified="2019-05-08" version="1">MFSQGKQGSLFSLGRGPGGMTANDKTRNKALTQAEKYEQALVTAKVFLEDSRARMTKSMDKYSAVVNSNYWFYGYFGGNMVATMAACLALGNRWAFFRSYSGWIAVFGGYFGGRACLAAHSSMLLGGVVAQLNHEIEEAKRMDEQTDHIVPDYLREAERLTQVKYELVPTLPEAVEARAHHTEQTLDDRADALIEAYMKRKEALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0K8</accession>
    <name>A0A3S7X0K8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_270013700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0K8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1110"/>
    <dbReference type="OrthoDB" id="273067at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1035" mass="108761" checksum="5152FF67E56F990A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2H7</accession>
    <name>A0A3S7X2H7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290023800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2H7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2630"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1230" mass="129372" checksum="657AEC3A7F20A473" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2W9</accession>
    <name>A0A3S7X2W9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Serine/threonine_protein_kinase_putative/GeneDB:L mjF.29.2720</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_290034400</name>
        <name evidence="7" type="ORF">LDHU3_29.4150</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5432000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2W9"/>
    <dbReference type="SMR" id="A0A3S7X2W9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4150"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001603">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5432000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="323" mass="36225" checksum="485424311D5DBE07" modified="2019-05-08" version="1">MSLRSAMHASDVDDAGRALQSTQRSIVSISRLTNEMSEVRAMSEGSFGVVKCYRHDFDKLEYAVKQTKRPICGESNLQQQLQEIYALSSFPHRHIVRYFDGWVEDRAVFVRLEKLDDCMASLPPPVSESVLTAMLHQTSTALYELHSHDVVHMDVKPENILRRQLDADTFIFKLCDFGLARPLNGKDSVTGEHFLGLNDDDGDRRYMSPELLKNLHDVVGPPADMYALGKSCEAMMTATEDPSNTSARHLESYSPAFIALIESMLCEDPARRPSAFQVVQATLPERLLSDGGLLELQRRIDAIRCEISDLDASDNDVMSSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X318</accession>
    <name>A0A3S7X318_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_300010400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X318"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0710"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1110"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="947"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1148" mass="119361" checksum="B273012282B38BEF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3A1</accession>
    <name>A0A3S7X3A1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300020100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3A1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1890"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="314" mass="33925" checksum="E629D8086081E6E3" modified="2019-05-08" version="1">MPRTGRHVAEVIEAATAGLARLRVVCWRKCGRSAALLCSCCTALLEPELLYGATVWWDRASRSCSRSLEDFHVEAAAAIVGTAMCSESRDLPEEADPLPLDSTVLLRRTRLCLSSTARGGFLVHLARQAHTPDAGAATALRQLSCGHAGIGPCGLRMHTPPSCAAAARASHGSLSLASVGWRAPARMTNLQDRQRQRSRRQQHGSRTWSPVSDAGPPSPATAVDDATRDGKRYLAAAAPHQRNKGAGAHETTGHHPRPAPRRRLTRTFGLLQRWVTGRVEMVCRWRAAHTQAGVVPMAQDVLGEGTRKGKRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3L8</accession>
    <name>A0A3S7X3L8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJ domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300023200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3L8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2500"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000234">
        <property type="entry name" value="Putative DNAJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="740" mass="79377" checksum="1189F9A85E5FFB67" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5B3</accession>
    <accession>E9BNJ7</accession>
    <name>A0A3S7X5B3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC21_20035</name>
        <name evidence="17" type="ORF">LDBPK_320940</name>
        <name evidence="16" type="ORF">LdCL_320015000</name>
    </gene>
    <organism evidence="16 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phosphoethanolamine + CTP + H(+) = CDP-ethanolamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="EC" id="2.7.7.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:24593"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863510.1">
        <property type="nucleotide sequence ID" value="XM_003863462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5B3"/>
    <dbReference type="SMR" id="A0A3S7X5B3"/>
    <dbReference type="GeneID" id="13390323"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1230"/>
    <dbReference type="OMA" id="QCKYINA"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000249">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000108">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="15">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ36825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="402" mass="45299" checksum="DA3B47919FE712ED" modified="2019-05-08" version="1">MPTVPSSTPSPASAPSVEVPPGKVWLNADEPNDEYSLFCTEAIPPKVPGTVRIWVDGCFDMLHFGHANALRQARRLGDELFVGCHSDEEVMRFKGPPIMHAEERYEALRACKWVDYVVENYPYCTRLKDVERLEIDYVVHGDDISVDLNGRNSYQEIIDAGKFKVVKRTEGISTTDLVGRMLLCTKNHMLKSVDEVQLESSLFEHSPTMHCLTTSRKIVQFSNNSSPKSGDRIVYVDGSFDLFHIGHIRVLQKARELGDYVIAGVYEDQVVNEHKGKNYPIMNLNERVLGVLSCRYVDEVVMGVPFDVSKDVIDGLHINVVVGGKFSDLVVEEGGSTRYKVPKAMGIYHEVDSGCTLSTDSLIDRVVENRLAFLKRQAEKQIKDKKSQEIKPDDYRNVREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6J5</accession>
    <accession>E9BQ38</accession>
    <name>A0A3S7X6J5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_10895</name>
        <name evidence="5" type="ORF">CGC21_38065</name>
        <name evidence="4" type="ORF">LDBPK_331090</name>
        <name evidence="2" type="ORF">LdCL_330017000</name>
        <name evidence="3" type="ORF">LDHU3_33.1690</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863933.1">
        <property type="nucleotide sequence ID" value="XM_003863885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6J5"/>
    <dbReference type="GeneID" id="13392330"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1690"/>
    <dbReference type="OMA" id="YYCAEEN"/>
    <dbReference type="OrthoDB" id="239897at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="177" mass="18600" checksum="69EFDBEEC0707F83" modified="2019-05-08" version="1">MGCSASKSKEVRRSGKPGASAATASSPIGASANGARAQKPTAETAPAPPAQPNQNGTTLPANKSPSSHSVEAPSGRAADANHDNKSTNVDSTEAPDKGPRQNGAGLGNGDVDENGNAVLLPKGVWVKTEGTPYYYCLEENLYFHPPSCQFYDPTNEMWYDPDKDEWYRDDGSDAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7R3</accession>
    <name>A0A3S7X7R3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340018600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7R3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1990"/>
    <dbReference type="OrthoDB" id="272644at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="665" mass="74871" checksum="E0A216D80F8579FA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7Y2</accession>
    <accession>E9BQY3</accession>
    <name>A0A3S7X7Y2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_21515</name>
        <name evidence="15" type="ORF">CGC21_26235</name>
        <name evidence="14" type="ORF">LDBPK_341840</name>
        <name evidence="12" type="ORF">LdCL_340026100</name>
        <name evidence="13" type="ORF">LDHU3_34.3160</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864344.1">
        <property type="nucleotide sequence ID" value="XM_003864296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7Y2"/>
    <dbReference type="SMR" id="A0A3S7X7Y2"/>
    <dbReference type="GeneID" id="13392753"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3160"/>
    <dbReference type="OMA" id="PRLHTSY"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001594">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5433768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="385" mass="42910" checksum="C0496476925F55DE" modified="2019-05-08" version="1">MPPKLKPLPAKKSTLPPELPEESDELTVGNIRVGPRGVEFTGEGDLQVRRPDLNFENLKRVRQLGQGTQGNVSMYVTADKSVFAVKKITIPVTLDTRTRQTVAAELRNIFSAQSNEYTVNLYNAFYRNRALRLVMEYMDWGNIDELIAEKVKIPPTVCGYIASQMLHALAVLHTKSNIVTEPNQHKSLRQIHRDIKPANVLLSTTGCVKLADFGIATSAETIGVNSFVGTATYMSPERIQGRRYSTPSDIWSVGVVVAQMLLGHYPFSSVSKGFMALLREINSVEKYPLMDETGCSQETQDFIDSCLRQDPDDRSSAFELLESPWIKYCEEHGKAEMVALLASLGDRNRQYREDDALQAASRETSSLSLPRDTSETCKADNPLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X860</accession>
    <accession>E9BR38</accession>
    <name>A0A3S7X860_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_21270</name>
        <name evidence="6" type="ORF">CGC21_26485</name>
        <name evidence="5" type="ORF">LDBPK_342400</name>
        <name evidence="3" type="ORF">LdCL_340031600</name>
        <name evidence="4" type="ORF">LDHU3_34.3960</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864399.1">
        <property type="nucleotide sequence ID" value="XM_003864351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X860"/>
    <dbReference type="GeneID" id="13392808"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3960"/>
    <dbReference type="OMA" id="VTFHVTH"/>
    <dbReference type="OrthoDB" id="263354at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP40143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="557" mass="63965" checksum="CB74D85AC7933B88" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8R4</accession>
    <name>A0A3S7X8R4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteophosphoglycan ppg3, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_350010100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0660"/>
    <dbReference type="OrthoDB" id="687555at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052592">
        <property type="entry name" value="LRR-RLK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054:SF82">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48054">
        <property type="entry name" value="RECEPTOR KINASE-LIKE PROTEIN XA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019432343" evidence="4">
        <location>
            <begin position="35"/>
            <end position="4997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1502"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1638"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1708"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1824"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1915"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2048"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2136"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2448"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2655"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2787"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2905"/>
            <end position="2942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2961"/>
            <end position="2983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3022"/>
            <end position="3058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3182"/>
            <end position="3303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3315"/>
            <end position="3431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3449"/>
            <end position="3493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3524"/>
            <end position="3563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3583"/>
            <end position="3641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3678"/>
            <end position="3715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3736"/>
            <end position="3772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3785"/>
            <end position="3843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3875"/>
            <end position="3943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3999"/>
            <end position="4023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4065"/>
            <end position="4088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4106"/>
            <end position="4143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4165"/>
            <end position="4343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4355"/>
            <end position="4383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4401"/>
            <end position="4481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4517"/>
            <end position="4637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="667"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1471"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1638"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1650"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1708"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1726"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1754"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1770"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1788"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1915"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1958"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1974"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2136"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2163"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2448"/>
            <end position="2489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2490"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2655"/>
            <end position="2665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2666"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2787"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3022"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3049"/>
            <end position="3058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3182"/>
            <end position="3197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3198"/>
            <end position="3226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3227"/>
            <end position="3258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3259"/>
            <end position="3303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3315"/>
            <end position="3374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3388"/>
            <end position="3410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3417"/>
            <end position="3431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3452"/>
            <end position="3479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3480"/>
            <end position="3493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3524"/>
            <end position="3537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3538"/>
            <end position="3554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3599"/>
            <end position="3634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3786"/>
            <end position="3813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3814"/>
            <end position="3843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3875"/>
            <end position="3933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="3934"/>
            <end position="3943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3999"/>
            <end position="4013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4014"/>
            <end position="4023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4065"/>
            <end position="4077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4078"/>
            <end position="4088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4106"/>
            <end position="4123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4124"/>
            <end position="4143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4165"/>
            <end position="4190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4191"/>
            <end position="4203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4204"/>
            <end position="4242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4262"/>
            <end position="4276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4277"/>
            <end position="4291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4308"/>
            <end position="4343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4356"/>
            <end position="4383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4401"/>
            <end position="4443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4444"/>
            <end position="4481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4517"/>
            <end position="4535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="4536"/>
            <end position="4551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4552"/>
            <end position="4606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4614"/>
            <end position="4637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU82851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4997" mass="507503" checksum="C6353998006B63E5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9J4</accession>
    <name>A0A3S7X9J4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_350035500</name>
        <name evidence="12" type="ORF">LDHU3_35.3970</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9J4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350035500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3970"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46036">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46036:SF5">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="141" mass="16362" checksum="29EAB1881C2E209D" modified="2019-05-08" version="1">MPSRRMLHTMIRVGDLDRSIKFYTERLGMKVLRKWDVPQDKYTLVFLGYAPEMSSTVLELTYNYGVTSYKHDEAYGHIAIGVEDVKELVADMRKHDVPIDYEDESGFMAFVVDPDGYYIELLNEKMMMEKAEADMKEQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAD7</accession>
    <accession>E9BTB1</accession>
    <name>A0A3S7XAD7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger of a C2HC-type, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Zinc-finger_of_a_C2HC-type_putative/Pfam:PF13913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_360520</name>
        <name evidence="8" type="ORF">LdCL_360010100</name>
        <name evidence="9" type="ORF">LDHU3_36.0680</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865168.1">
        <property type="nucleotide sequence ID" value="XM_003865120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAD7"/>
    <dbReference type="GeneID" id="13388054"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0680"/>
    <dbReference type="OMA" id="NLHPCSK"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF5">
        <property type="entry name" value="ZINC-FINGER OF A C2HC-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="349" mass="36455" checksum="6A7E25DE93D873AC" modified="2019-05-08" version="1">MPRPQFITCQLCGKGFGSASINIHIPQCYEKAIKRWQLNPQGPRPVMPPLHGKPAAKASNGGSSGIAFAGQPRGAGMSAVRSLQMQSMPPESVEPENMNLHPCSKCGRTFNFDRIAYHESVCKGDQKRRVFDSSKQRCAGGEGDDAYAGGVFGAPSEVRRGRTKKLGTANTTSRYTPAPAPQTNWRQQHEEFIAAIRSAKRAGAEAQSMWGTGPAAPSFSPSRGPARGGLFGATSSGYGDRAGMSARVSASTRRIPPLMAKQNETLKQGIATGGRAARAKEGGGIPAPRTGRPFGRPTPPLGRDSFGGRSDRFGSRGGGGGMGGGGGGGGRILNDNKTSVGMLQAMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAF4</accession>
    <accession>E9BTF6</accession>
    <name>A0A3S7XAF4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9 10">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_12805</name>
        <name evidence="10" type="ORF">LDBPK_360960</name>
        <name evidence="9" type="ORF">LdCL_360014600</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865213.1">
        <property type="nucleotide sequence ID" value="XM_003865165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAF4"/>
    <dbReference type="GeneID" id="13388098"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1270"/>
    <dbReference type="OMA" id="WKVIYDY"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001732">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP48211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="790" mass="87466" checksum="2418D94A5DC887EB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBJ5</accession>
    <name>A0A3S7XBJ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360056300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360056300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6610"/>
    <dbReference type="OrthoDB" id="267767at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1822" mass="190911" checksum="442F43CCBBA2BEB6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC33</accession>
    <name>A0A3S7XC33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360070100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC33"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360070100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8320"/>
    <dbReference type="OrthoDB" id="441129at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF0">
        <property type="entry name" value="DUF4515 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="670" mass="73145" checksum="A977033FC2E1842D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJK8</accession>
    <name>A0A451EJK8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine rich repeat/Leucine Rich Repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_030005100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJK8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0010"/>
    <dbReference type="OrthoDB" id="261745at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1069" mass="114856" checksum="04E12CC048D81F31" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAH0</accession>
    <accession>A0A3S5H6H3</accession>
    <name>E9BAH0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTP-binding protein Rab7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_101260</name>
        <name evidence="3" type="ORF">LdCL_100019600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858960.1">
        <property type="nucleotide sequence ID" value="XM_003858912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAH0"/>
    <dbReference type="GeneID" id="13389317"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1620"/>
    <dbReference type="OMA" id="AFYRNCQ"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="PhylomeDB" id="E9BAH0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001483">
        <property type="entry name" value="Small GTP-binding protein Rab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="223" mass="25030" checksum="92ABC5787F52E9A7" modified="2011-04-05" version="1">MEEDLAYKIIVIGSVSVGKSNITSRFCDGAFYPDLVPTLGMDFKYSSCNTLEKRPRCVRLQVWDTSGQDDFVTLTTAFYRNCQGALLCFDLTNRQSFEDLDQWYERLERYSPVVPPLILVGCKLDLVESHLDEQGEGIVLGSHRQIAKSEADAWARYHSCLCYLETSAKENTNVSQAFQQLATYIASVANPGAKHAGRILGPGGRLLVEEEEEKQKKRQCCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>E9BB51</accession>
    <accession>A0A3S7WS81</accession>
    <name>E9BB51_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_120710</name>
        <name evidence="5" type="ORF">LdCL_120018900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859188.1">
        <property type="nucleotide sequence ID" value="XM_003859140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BB51"/>
    <dbReference type="GeneID" id="13390172"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1410"/>
    <dbReference type="OMA" id="YFTCTHP"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="PhylomeDB" id="E9BB51"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="541"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="608" mass="65258" checksum="347F301641EBBE53" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEN1</accession>
    <accession>A0A3S7WW00</accession>
    <name>E9BEN1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_200840</name>
        <name evidence="4" type="ORF">LdCL_200013100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860424.1">
        <property type="nucleotide sequence ID" value="XM_003860376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEN1"/>
    <dbReference type="SMR" id="E9BEN1"/>
    <dbReference type="GeneID" id="13386211"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1050"/>
    <dbReference type="OMA" id="THVAEWV"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="PhylomeDB" id="E9BEN1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30258" checksum="F4310AA7DCF17929" modified="2011-04-05" version="1">MTKLLVANAGTWQPSPEQFSSAVEQLHREDSVRRAIESARVSATRQGSMHPSPENKARLLARHLLLCELIDCGNTQAKRQFCKRDVRLLTSAYGKPLTAPYRDGNYSVTHVAEWVCCAHSMAAPLGVDVAAVHPQDSAPFSLCLSKQELARVEAVQRKQRPSLFALFWTLKEAVLKALGLGLSTRLQMYDICLDSVKLENLSLLPNVEPASVYTAPKYRLMVSLQGNTKQAWACSCFMLPGDPPHILSVVLREEVMDGVIEVMFVSPQTALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFL8</accession>
    <accession>A0A3Q8IC30</accession>
    <name>E9BFL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_220012</name>
        <name evidence="1" type="ORF">LdCL_220006000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860749.1">
        <property type="nucleotide sequence ID" value="XM_003860701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFL8"/>
    <dbReference type="GeneID" id="13386571"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220012"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220012.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0160"/>
    <dbReference type="OMA" id="FMRQTWA"/>
    <dbReference type="OrthoDB" id="270452at2759"/>
    <dbReference type="PhylomeDB" id="E9BFL8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26815" checksum="4A88B598312AF73F" modified="2011-04-05" version="1">MCAAMSLAEASTPLVNVYAKPQEVETRITPSRFTVSYASRAPSSCSPMPVVPSCARDDMALQKEMVEAHKQAELAAFIAKHEKTCAISEADRRRSIIMLLNTAAQRDIDEGSHAGYPQQVVDFMRQTWAAFIQQAKNFYQEDADEPFKMELSRNALENTSSIGVWFTGPQISLPLRRYTVQVVGADGAPQNITAVGLLSFTYSTYVMHLRSMSQQSALDGLARMQEQLGTDSLFLPQILVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJ50</accession>
    <accession>A0A3S7X0N8</accession>
    <name>E9BJ50_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_271180</name>
        <name evidence="2" type="ORF">LdCL_270018300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861971.1">
        <property type="nucleotide sequence ID" value="XM_003861923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJ50"/>
    <dbReference type="GeneID" id="13389233"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1850"/>
    <dbReference type="OMA" id="EMFHIER"/>
    <dbReference type="OrthoDB" id="266171at2759"/>
    <dbReference type="PhylomeDB" id="E9BJ50"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="442" mass="50374" checksum="F5A6FA4F25D8F71A" modified="2011-04-05" version="1">MQSRVFYFPGKESKPDYEPRISRRVNEILRQSSPQARSRTSLQSNWQPYAPILSIHSQLRQEAESRSPSRANVKHPMRASSVSSLTPHGSQVVSPSRLRYVGAELTKRVSPSDLLRGASVTKFRQQSSSQCIWDSPRHPKASNTLPVNNESFSTVLPCSLHPLLQQALLLVESAEFEERFAFCQEEMDAFDSIITVLGVAKEVEVIRLAAFEMFHIERASRRALKRQERHERQILRLWYSESYEDALLSEEVRVIRQQSEESRSFFSNSLSRSRSTSLKQQSQDLFDMAAPRNGSPSSKKVPRLQKRDKIAHMASLLFSASIRQGEGIRGSSPTDNCDEVLHSSPRVLSPMPSEPYFSHTIGSSHLSHRSSDSVNVADRRRYYREYGDHCRRTLESMEADLEDRIARQEALLLPARQSYQSSSPFSLIRRQAPLLLPKSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJB6</accession>
    <accession>A0A3S5H7I2</accession>
    <name>E9BJB6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_271860</name>
        <name evidence="9" type="ORF">LdCL_270025800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862037.1">
        <property type="nucleotide sequence ID" value="XM_003861989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJB6"/>
    <dbReference type="GeneID" id="13386772"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2840"/>
    <dbReference type="OMA" id="HIKKMWL"/>
    <dbReference type="OrthoDB" id="273318at2759"/>
    <dbReference type="PhylomeDB" id="E9BJB6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001063">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000875">
        <property type="entry name" value="Protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="273"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="808"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="958" mass="101279" checksum="B4504423D5ACE58C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKQ7</accession>
    <accession>A0A3S7X2C1</accession>
    <name>E9BKQ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_291110</name>
        <name evidence="2" type="ORF">LdCL_290016200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862528.1">
        <property type="nucleotide sequence ID" value="XM_003862480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKQ7"/>
    <dbReference type="GeneID" id="13387266"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1540"/>
    <dbReference type="OMA" id="EAHAVFT"/>
    <dbReference type="OrthoDB" id="277985at2759"/>
    <dbReference type="PhylomeDB" id="E9BKQ7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="724" mass="79063" checksum="77974E3C8CE27E8B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPN8</accession>
    <accession>A0A3S7X774</accession>
    <name>E9BPN8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine peptidase, Clan CA, family C51, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">D-alanyl-glycyl endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_333000</name>
        <name evidence="3" type="ORF">LdCL_330037100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864124.1">
        <property type="nucleotide sequence ID" value="XM_003864076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPN8"/>
    <dbReference type="GeneID" id="13392520"/>
    <dbReference type="KEGG" id="ldo:LDBPK_333000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4180"/>
    <dbReference type="OMA" id="PSNAAIC"/>
    <dbReference type="OrthoDB" id="299748at2759"/>
    <dbReference type="PhylomeDB" id="E9BPN8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF14">
        <property type="entry name" value="D-ALANYL-GLYCYL ENDOPEPTIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="223"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="404" mass="44372" checksum="6F08A9944A0DCE5F" modified="2011-04-05" version="1">MKNKQPTTVFASLFAYHHFLIPMRSRQPPSGGVEDHADVAASTVLRSSASSSSAAAAASLLQDEVLPRLRKESGPSNAAICDAYATRLRQEATEEERRRGPHWRARCSPSILVALLIWATIALVVYMKVDNSRLRPGAAPDTTSVETPLSQLPESCRGHYCLREGGKEPFGAVLGAHDGVFAYSNCNSDTCTSLLKYQMAIPLPPGARTALDAPHATTRLMTTGMKWQCVEFARRYWMLRGKPTPAFFGPVVGAADIWDTLTHVTFLDNATTAPLLKFKNGARLGYGGSAPRVGDLLIYPRDAEGFFSYGHVAVVVRVEMTTKAEADDSYMDAAVTSSKPRQRHGLVYLAEQNWDSATWPNPYHNYSRSLPLVVLESAEGLPLQYTIEDSIHGIQGWVRYDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ60</accession>
    <accession>A0A3Q8IGU1</accession>
    <name>E9BQ60_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_331290</name>
        <name evidence="7" type="ORF">LdCL_330019100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863955.1">
        <property type="nucleotide sequence ID" value="XM_003863907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ60"/>
    <dbReference type="GeneID" id="13392350"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1940"/>
    <dbReference type="OMA" id="FTITQWR"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ60"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001232">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044715">
        <property type="entry name" value="WDR86-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489:SF11">
        <property type="entry name" value="WD REPEAT DOMAIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ37272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="621" mass="66762" checksum="7468758864EC6278" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQJ8</accession>
    <accession>A0A3S7X7D6</accession>
    <name>E9BQJ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_340440</name>
        <name evidence="2" type="ORF">LdCL_340009500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864209.1">
        <property type="nucleotide sequence ID" value="XM_003864161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQJ8"/>
    <dbReference type="GeneID" id="13392618"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0610"/>
    <dbReference type="OMA" id="CDFISRD"/>
    <dbReference type="OrthoDB" id="273315at2759"/>
    <dbReference type="PhylomeDB" id="E9BQJ8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="418" mass="45257" checksum="9373FAF3B3FEBD63" modified="2011-04-05" version="1">MTGVSSFEVRLSPYVPPLQWCRAVDGVFGSHHFVCGSYTCGIDEPRDDNDDSAGAAHTREAWKERDTLRTPPKAVVDAAATDVAPHTPSAGPPVRMPRREGALAAVWAGTPAAEETPCCSFALSSGHLPLRVAGVLNGNMPLDNATSSIPGTRVLCLVALDGSLLTGRTCPDSPSPSWSRDLFDTLCDFISRDVMPRVSLRLIDGTWARAEASEHLLDDVCQVRQMLGTSYVVQYPSDAAAAAATRARSIVMVLDLSVPLQKLLSTLPSMRTSSPSPATDAKSERRRRCLATQFAEAVQDTIGQLVSQHPDVFAFTREAARATESALVAQLSRGPTHFTREMLCRSIAASVSQILSLSSNAAFVEEVVRLLWGCETHVEPTDVATATERSRESLRISQRQPVQIQRRIEERLMSAIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQK1</accession>
    <accession>A0A3Q8IGY8</accession>
    <name>E9BQK1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_340470</name>
        <name evidence="2" type="ORF">LdCL_340009800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864212.1">
        <property type="nucleotide sequence ID" value="XM_003864164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQK1"/>
    <dbReference type="GeneID" id="13392621"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0640"/>
    <dbReference type="OMA" id="CHCCPCK"/>
    <dbReference type="OrthoDB" id="266951at2759"/>
    <dbReference type="PhylomeDB" id="E9BQK1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="937" mass="97779" checksum="9C4B5BEED54EB631" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BS65</accession>
    <accession>A0A3S5H7Z2</accession>
    <name>E9BS65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_351920</name>
        <name evidence="2" type="ORF">LdCL_350024400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864774.1">
        <property type="nucleotide sequence ID" value="XM_003864726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BS65"/>
    <dbReference type="GeneID" id="13387653"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2520"/>
    <dbReference type="OMA" id="PPFLDIA"/>
    <dbReference type="OrthoDB" id="272690at2759"/>
    <dbReference type="PhylomeDB" id="E9BS65"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="448" mass="47415" checksum="589ADDAD1B49C130" modified="2011-04-05" version="1">MAGTLVSFTPSTAGVLGGAHSVDAQLSDIPESAPVPCFYCLCSVCGQWLAEVPTVRCDACGSRTHITCARDVYSNEWLYDEVAVASTAATSAGGGTLGLPNAASAAARNRRTQYTGREPRNGEGTAGSPTHAAVLAAPSGLSVSPPLSRDSSHTNLLPSPQALRSAAAKIDKEYNYYCHPDCAMGMEVLRNPQFNATLSRTVEHAFAREWARTRESLVAAGVLRDHKHEAGALGDAAAEEQAPLPSYSPVKSPSAAPMKVEAAEESTAASSFCPSPPPTATASPSVPEGDMHGCAPHASVANFPDIAACHPSVALEVLRLYHQLRAEAWAEYFEQERHHFGHPLFYPPPFLDIARDAALGHVVEAASPQGQAARLYLLDRSTHPVGSAVAIPVGVLTRWQQPTAAPLIKENDSNNFVAEALERIVNDAVAPETVVVYRKCSKEGRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>E9BS99</accession>
    <accession>A0A3Q8IJ19</accession>
    <name>E9BS99_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_352290</name>
        <name evidence="1" type="ORF">LdCL_350027800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864808.1">
        <property type="nucleotide sequence ID" value="XM_003864760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BS99"/>
    <dbReference type="GeneID" id="13387686"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2920"/>
    <dbReference type="OMA" id="FDAPWHL"/>
    <dbReference type="OrthoDB" id="273258at2759"/>
    <dbReference type="PhylomeDB" id="E9BS99"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="534" mass="57768" checksum="8AEC0F0A4C4C8615" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8Y8</accession>
    <accession>E9BAK2</accession>
    <name>A0A3Q8I8Y8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell cycle sequence binding phosphoprotein (RBP45), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cell_cycle_sequence_binding_phosphoprotein_(RBP45 )_putative/GeneDB:LmjF.11.0140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_110140</name>
        <name evidence="3" type="ORF">LdCL_110006300</name>
        <name evidence="4" type="ORF">LDHU3_11.0160</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858992.1">
        <property type="nucleotide sequence ID" value="XM_003858944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8Y8"/>
    <dbReference type="GeneID" id="13389500"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0160"/>
    <dbReference type="OMA" id="RMLQYES"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="292" mass="33079" checksum="998484112D8638EC" modified="2019-04-10" version="1">MMNTSLLVQDVDEIQCAVDRWYRQSSSNLQASHAAFTAQLRQLQERLGLDPGAPTLSAHVDAMITPPRHMYLSDDNNSGSPPMASPPVSRGQLNYDHLLDEVVSKGASMPPFNPEEEAERRRRPNAESVRAPSTPPEDCNGPCQVLVEFKRKRILQYESPYYVAPGEHVVVGGDRGEDIGLVTHTWRDAEAHQLGENRDKGVGKVLRVASVLEVTQLQGVQTELETRAVEVAQEKVQESGLPMRIVDAEYQFDRRKLTFYYQSMHRLDFRTLVRDLYKTFRARIWMEPDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB42</accession>
    <name>A0A3Q8IB42_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ttaggg binding factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180017800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB42"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1590"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="797" mass="82380" checksum="AC69D11FE25D1C69" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBD7</accession>
    <name>A0A3Q8IBD7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220011400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0840"/>
    <dbReference type="OrthoDB" id="266024at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1785" mass="184762" checksum="0787A57239BDE4B4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBK6</accession>
    <accession>E9BEN9</accession>
    <name>A0A3Q8IBK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_200920</name>
        <name evidence="2" type="ORF">LdCL_200013900</name>
        <name evidence="3" type="ORF">LDHU3_20.1130</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860432.1">
        <property type="nucleotide sequence ID" value="XM_003860384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBK6"/>
    <dbReference type="GeneID" id="13386219"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1130"/>
    <dbReference type="OMA" id="GENCYSQ"/>
    <dbReference type="OrthoDB" id="415230at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35378">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="284" mass="30368" checksum="736F8A90F1DEE89A" modified="2019-04-10" version="1">MPPSGKVGSSAAQQVVDMDPLLVYFTFSRIRPRFSCGRTIESTLKQFRDGELHPRDLPLLSVLTDGAHYYSQNNRRLYVYKQLKREGLLDMLPVRLRPLPQTKRMRSKYSPQTCALNATLMRDTANRDGLRDASATAADSSDASDIEGSHDDHDACTSLAAVGEPGAGDDEFRRGNRSAPSSSSPPRPASCATGSGLEREAVGSGDTRKAPTRRNQKKQPQPQHGLALSQQSSNANCSETASQRPGKSKGAAAARSPSTSSSDGGGNGGTSALEAELRKLGLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICF8</accession>
    <name>A0A3Q8ICF8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat/Leucine Rich repeats (2 copies), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250023400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICF8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2210"/>
    <dbReference type="OrthoDB" id="10251250at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF10">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN 40K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1160" mass="120049" checksum="0ED2CEF8C916089F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDA9</accession>
    <name>A0A3Q8IDA9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_280030700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3480"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1357" mass="145746" checksum="606F905407FF3592" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDJ1</accession>
    <name>A0A3Q8IDJ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP response protein 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320047200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDJ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320047200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5290"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000318">
        <property type="entry name" value="Cyclic nucleotide-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF164">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="236"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="699" mass="79860" checksum="F918CA3510652584" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDS6</accession>
    <accession>E9BKA7</accession>
    <name>A0A3Q8IDS6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein_transport_protein_SEC13_putative/GeneDB:L mjF.28.0650</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12 14">protein transport protein SEC13, Putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_13750</name>
        <name evidence="16" type="ORF">CGC21_21865</name>
        <name evidence="14" type="ORF">LDBPK_280690</name>
        <name evidence="12" type="ORF">LdCL_280011500</name>
        <name evidence="13" type="ORF">LDHU3_28.0860</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862168.1">
        <property type="nucleotide sequence ID" value="XM_003862120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDS6"/>
    <dbReference type="GeneID" id="13386904"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0860"/>
    <dbReference type="OMA" id="VKLWTHS"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002244">
        <property type="entry name" value="Protein transport protein sec13, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5431449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="359" mass="37805" checksum="8AC716E77E81BFD2" modified="2019-04-10" version="1">MSDTLLDTGHTAAVTDIAADANGRHLATASSDGTVHVYESVTSSSKEASQYKGGPQPTTWSPVAVLQCSSEEQAATVTCVAWAPPALYTAALVTCTELANEVALWCDVGNDAQYRKIYVYTLAAPGWCVAWAPHEYGKLFAVGCADGAVVVFTGGPDGTWDIHSFESHPHGCCGLSFAPFFPPGALLMAPLEKDVGNVPGNAPPIPLAPPRMITCGGGRFVKLWTHSFAPLPGEEGSGAPLGSVWTSIELEAAEATSAPAWREVCWAPNLGLPFTYIAAGSEDGLVAVWVQDGPASNPWQCRLLPPPHGTPGENVTKLSWSLVGTFLLVSYADGTVAMWKETSNHGAWRVVSELENPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE48</accession>
    <accession>E9BFM5</accession>
    <name>A0A3Q8IE48_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32880</name>
        <name evidence="3" type="ORF">LDBPK_220060</name>
        <name evidence="2" type="ORF">LdCL_220006700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860756.1">
        <property type="nucleotide sequence ID" value="XM_003860708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE48"/>
    <dbReference type="GeneID" id="13389321"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0280"/>
    <dbReference type="OMA" id="YVHEGQR"/>
    <dbReference type="OrthoDB" id="273246at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="260" mass="28273" checksum="71BFF2D4D68A9FB0" modified="2019-04-10" version="1">MPRTRDTHQQVQEVVDGIDGVASQVHVDVNEKAQDAQKSISGAAATVQKAPDAAQNGVQNAMNTVQSYVHEGQRLASEHKVQLQEAVKKAVNAAHEYVEDARKKADPYVESAKAKVDSARASVENARHSAQNAVDNAKEQVTAVRTKVTAKTQPYVSNYQEFDVTKTAAFHVLIHIISSVLYIAWRLTQLIPSAQHMITVIQQKEADAAVARNCATVMQKVPVVGPRAVEVATIAVNNVCTDLNEQISQYTTATQRPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE75</accession>
    <name>A0A3Q8IE75_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_180010900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE75"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0780"/>
    <dbReference type="OrthoDB" id="10447551at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10013" checksum="E3FE9B17CDC624C5" modified="2019-04-10" version="1">MSCGLAFSCPLTKPSPLRPVECPRRFSRSVLSIVLLRTFDCLKTSAGEREKHQGGCSPRGVGKVARRRGAHERAATAWGLIEMQRCLLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEA3</accession>
    <name>A0A3Q8IEA3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270019200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEA3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1960"/>
    <dbReference type="OrthoDB" id="273760at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="315" mass="33776" checksum="960BD2EA636AD403" modified="2019-04-10" version="1">MLNTRVQRPPPPRRAPPAAAMIKDVSPDAYISTHVILRLSGAAVISQQLLQVKDWVSDIKMAVTTADDALKAISTNPAVQPPSLSDGATTGGDDVQSLAFASVALSKLAEEEETQDAFYAKLSETAFVRAEVQMGSQDARLQRYKQQVECQLASSMADGLLPPQQRKNSVPPEKRQMLLNPYSTVRRKLPNTASNGNSALPSANTPMPPTITSPYRTSTSSAVPSPQSPSYSTPAAVNGGYTSYSPHSSDAAGSPSRATARYGATATQQPLTHGAHDHRRPLRRGNAIAGMHFGQPPQPLHQNHQQSSRPHYQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEI1</accession>
    <name>A0A3Q8IEI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340034600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEI1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_044340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340034600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4310"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21797" checksum="7110A3E4183C7884" modified="2019-04-10" version="1">MGCKFTFLVYAILQLIAFLSVLIGTPLDMFRGDLNIFDKRPCVTLWGYKVMCDSIVYVDSTDTRWNRCHNRRNRFRMAEALAVISIMVYCAAFVLGVIMLFCCSLLRWVCLALNVVGLLTLGITWGLMVTEFNKGDGPLCPPLKNNYKFGYGFFLLLVAWVLDLVDIVFLLIPVHRKNSVEGGTSKIYTEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEU0</accession>
    <accession>E9BGU7</accession>
    <name>A0A3Q8IEU0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial SSU ribosomal protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_16055</name>
        <name evidence="2" type="ORF">LDBPK_240850</name>
        <name evidence="1" type="ORF">LdCL_240013500</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861175.1">
        <property type="nucleotide sequence ID" value="XM_003861127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEU0"/>
    <dbReference type="GeneID" id="13390861"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0990"/>
    <dbReference type="OMA" id="IGQWRAP"/>
    <dbReference type="OrthoDB" id="275043at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000559">
        <property type="entry name" value="Mitochondrial RNA binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="811" mass="94512" checksum="9D40F124AFB454E4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF31</accession>
    <name>A0A3Q8IF31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cullin-like protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_240029400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF31"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2940"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000065">
        <property type="entry name" value="Cullin-like protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000066">
        <property type="entry name" value="Cullin-like protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="417"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="744" mass="85519" checksum="5C717ECBD59C4A64" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFG4</accession>
    <name>A0A3Q8IFG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220012800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFG4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0960"/>
    <dbReference type="OrthoDB" id="265772at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="439" mass="49977" checksum="826A50CD9FA0D0A1" modified="2019-04-10" version="1">MSAQQQQPEENGDRMVAARAKAEAARMAAERRRSMNSDARERSNSPDIHDTPTPLRGATQERSSSVDLANGGIEALHGDSGEHRRNSSALKRRSSTPKKGMRGGSRRGSGVAAAGFSNASHSGTKKAAHPQTPEEYAAAIEEMRQEYERITMKDEELEERLQLYSDVVGLRKELVIVQEDEARLRQQLAATEAVIASSDLTVEKMVSIYEEEAQQSALQKLWMEESECHNPDTMEWAEIDVNNLRERVDEAHKKFTAAAEKADSLYLQQEEAINKTTDARERERATIAENHEREMEGLSEARIHARQVATEQHFHRHRGTAQAPPVVLTKDKERTTRQRRVDEVEFRTTAQVGKMKDELTELMEQVKMLKRHLDDSRQVTEEKRREYEASLKVVEAEGSEAREMKEGLLKEEEELKELKADLQAVLHYVRAKNREEEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFL1</accession>
    <accession>E9BLB1</accession>
    <name>A0A3Q8IFL1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rubisco LSMT substrate-binding family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Rubisco LSMT substrate-binding, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_34900</name>
        <name evidence="7" type="ORF">LDBPK_300160</name>
        <name evidence="6" type="ORF">LdCL_300006700</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862732.1">
        <property type="nucleotide sequence ID" value="XM_003862684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFL1"/>
    <dbReference type="GeneID" id="13385438"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0280"/>
    <dbReference type="OMA" id="RELWMSY"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000032">
        <property type="entry name" value="Rubisco LSMT substrate-binding, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF115">
        <property type="entry name" value="RUBISCO LSMT SUBSTRATE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="5">
        <location>
            <begin position="510"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="614" mass="67890" checksum="149D79FF1A7D2EA5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFP4</accession>
    <accession>E9BG25</accession>
    <name>A0A3Q8IFP4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_18560</name>
        <name evidence="15" type="ORF">CGC21_17670</name>
        <name evidence="14" type="ORF">LDBPK_230050</name>
        <name evidence="12" type="ORF">LdCL_230005400</name>
        <name evidence="13" type="ORF">LDHU3_23.0070</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860906.1">
        <property type="nucleotide sequence ID" value="XM_003860858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFP4"/>
    <dbReference type="SMR" id="A0A3Q8IFP4"/>
    <dbReference type="PeroxiBase" id="11259">
        <property type="entry name" value="Ldon2CysPrx"/>
    </dbReference>
    <dbReference type="GeneID" id="13389630"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0070"/>
    <dbReference type="OMA" id="NNFGVMR"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF177">
        <property type="entry name" value="TRYPAREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5430137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP50351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP51420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="226" mass="25384" checksum="900FDD2FD26960F5" modified="2019-04-10" version="1">MLRRLPTSCFLKRSQFRGFAATSPLLNLDYQMYRTATVREAAPQFSGQAVVNGAIKEINMNDYKGKYIVLFFYPMDFTFVCPTEIIAFSDRHADFEKLNTQVVAVSCDSVYSHLAWVNTPRKKGGLGEMHIPVLADKSMEIARDYGVLIEESGIALRGLFIIDKKGILRHSTINDLPVGRNVDEALRVLEAFQYADENGDAIPCGWKPGQPTLDTTKAGEFFEKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGC6</accession>
    <name>A0A3Q8IGC6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitogen activated kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_360045700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGC6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360045700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5200"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="695"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="950"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="977" mass="108247" checksum="91D6683A9FF2577F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGG4</accession>
    <name>A0A3Q8IGG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid aminotransferase, putative</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_270026700</name>
        <name evidence="10" type="ORF">LdCL_270026800</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGG4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270026700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3010"/>
    <dbReference type="OrthoDB" id="270718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000017">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44140" checksum="CBA6A3CA8ADBABDD" modified="2019-04-10" version="1">MLLSRRWHQASAARGSRAPVVSFTAAALTKTLVADPPPLPPMKGVAFGTLFTPHMVIIDFNDGRWGAPAIVPFANFSLPPQTSCLHYATQCFEGMKVYADIADITRAARGEKLEKQSLRLFRPDRNVARLRHSMRSLCFPDFDEAEMLKVIMEFVRTEKDYVPKEHGYSLYLRPAAIGTADSLGAAPSRSVRLFVIASPVGPYYLPPEDQSGAMAIKPVTLLAEDKRKRAWPGGTGGSKLGANYAGPLLVQEEAQALGYNQVLWLGSKDEVQEAGFMNFCTLWKTKEGKTELVTAPLDGTILPGVTRDSILALARSWGELEVSERPYYMSELAEALQEGRVMECFGCGTAAIVSSVSMIAYRGKEYSVPLSEPSYARRFLNEIMDIQYGKTPSPWSVKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGN2</accession>
    <accession>E9BSX2</accession>
    <name>A0A3Q8IGN2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_354530</name>
        <name evidence="12" type="ORF">LdCL_350050400</name>
        <name evidence="13" type="ORF">LDHU3_35.5970</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865030.1">
        <property type="nucleotide sequence ID" value="XM_003864982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGN2"/>
    <dbReference type="SMR" id="A0A3Q8IGN2"/>
    <dbReference type="GeneID" id="13387908"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350050400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5970"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000080">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm-F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8490" checksum="B4AFA3AC7BBD8678" modified="2019-04-10" version="1">MEANVPGAFLHSLIGKNVLVKSKWGPVYEGNLVSCDTFMNLQLRNAVEHAKQDTELGEMLLRNNNILYIREEASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGT1</accession>
    <name>A0A3Q8IGT1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_22330</name>
        <name evidence="1" type="ORF">LdCL_280022600</name>
        <name evidence="2" type="ORF">LDHU3_28.2300</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGT1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2300"/>
    <dbReference type="OrthoDB" id="267849at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP54307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="107" mass="10866" checksum="925DDE10B540C7AC" modified="2019-04-10" version="1">MSSSDSLAQARAPAGATAADEAAAITASYARGHFTTYYVDCAKLPSGGTASMSAAPGSPAANRADLRGAQTGSILTLGDFSVLPHPGYAGRRGKTLNKPLFLHQLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGT3</accession>
    <name>A0A3Q8IGT3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_330035200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGT3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330035200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3950"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1168"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="442"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="902"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1215"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="133208" checksum="0E304BD2D35FA985" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHC3</accession>
    <name>A0A3Q8IHC3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_25180</name>
        <name evidence="18" type="ORF">CGC21_28430</name>
        <name evidence="19" type="ORF">CGC21_28435</name>
        <name evidence="13" type="ORF">LdCL_290024000</name>
        <name evidence="14" type="ORF">LdCL_290024100</name>
        <name evidence="15" type="ORF">LdCL_290024200</name>
        <name evidence="16" type="ORF">LDHU3_29.2670</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHC3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1360"/>
    <dbReference type="OrthoDB" id="266388at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000086">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU80676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU80678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5431896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP50723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP52811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP52812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="132" mass="13923" checksum="52215FBC74943F4C" modified="2019-04-10" version="1">MATPRSAKKAARKSGSKSAKCGLIFPVGRVGGMMRRGQYARRIGVSGAVYLAAVLEYLTAELLELSVKAAAQSGKKRCRLNPRTVMLAARHDDDIGMLLKNVTLSHSGVVPNISKAMAKKKGGKKGKATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHH9</accession>
    <name>A0A3Q8IHH9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340043500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHH9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340043500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5630"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018548110" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="511" mass="56467" checksum="DEFDB7413FFB9D23" modified="2019-04-10" version="1">MRLPKALAVAALCFALCVCTASVGGHQVALISDIHYDPLYGTSRALKCTSDSSPMYGMQGCDSSLQLMARTLADVSAQNPSLVLYTGDWQRHKFANSSLAPAAIFKDVSERFHNVTVDGSLGAVAFSGAMGNNDVVPDYYYSLEDTVSEEELAHRVAAMRGAALLSDAEASVMRNCGYYTHMMDSVHVIVLHTLLWAHELQPPLPSNLSDPCNQFSFLRSELAKVRAANKRAIIMGHIPPGLNTYNVLKRGFGSAAGDMFWKEQYEATYNSIIREYKDLLVVQLFGHTHMFKLLTMPRNDVLGIVVPSISPIFGNHPSYLMANFSETWELEDAQSRYTIGEGVFHSGLSAKEVFSLNAGLHSVSDVRAAITLLATNDTMWDRFLTVFCGGEKRSQVFPHRKCDKQCRYIIVCSMLENNHTYIQRCVANYSLLPGPSQDTRTTVFMTAGIVLFSLFVMGASVAMLLMIRSGQTTLSWSNMKSAIWWKSLVSKQGSQTTPVLENELGDRRTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II88</accession>
    <accession>E9BMB5</accession>
    <name>A0A3Q8II88_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP synthase subunit C family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">V-type ATPase, C subunit, putative</fullName>
            <ecNumber evidence="11">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_6000</name>
        <name evidence="14" type="ORF">CGC21_36550</name>
        <name evidence="12" type="ORF">LDBPK_303720</name>
        <name evidence="11" type="ORF">LdCL_300042600</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="11"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863083.1">
        <property type="nucleotide sequence ID" value="XM_003863035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II88"/>
    <dbReference type="SMR" id="A0A3Q8II88"/>
    <dbReference type="GeneID" id="13385792"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300042600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4950"/>
    <dbReference type="OMA" id="TSPYMWG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ36393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP45919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="224" mass="22974" checksum="6A7FEF416EFD6E52" modified="2019-04-10" version="1">MPVEAEVLPTPTRLPPDDAMHVVGSLIRYILIIVIVVFGIIPALCGTVFPPFSALWSILKAVSPYAWASMGTGIGIALSILGAAWGILTSGASISGAAIRAPEIRSKNLISIIFCEAVAIYGVILSIIMMGKIQASSSSVGSGGVYRYETIVGGYTLFAAGIAVGIGNMACGIAVGIVGSSCAIADAHSSSLFVKVLVIEIFASALGIFAVITGILMAQKVQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIX9</accession>
    <name>A0A3Q8IIX9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_320006100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIX9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0200"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001164">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF18">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="267"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1076" mass="113933" checksum="58ACAC26A643B4DD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ78</accession>
    <name>A0A3Q8IJ78_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_350016700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ78"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1560"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.520.10:FF:000002">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="entry name" value="ApbE-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="ApbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="887"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123050" checksum="9E9321767B84AF19" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJA5</accession>
    <name>A0A3Q8IJA5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperonin HSP60, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">groEL protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_360027000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJA5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2770"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="566" mass="60495" checksum="0069909F8B2FFA06" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK22</accession>
    <accession>E9BE78</accession>
    <name>A0A3Q8IK22_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_19175</name>
        <name evidence="8" type="ORF">LDBPK_190840</name>
        <name evidence="7" type="ORF">LdCL_190013500</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860261.1">
        <property type="nucleotide sequence ID" value="XM_003860213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK22"/>
    <dbReference type="GeneID" id="13386073"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0990"/>
    <dbReference type="OMA" id="CREHPEQ"/>
    <dbReference type="OrthoDB" id="261451at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000221">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="136" mass="14734" checksum="D89D0FC17EC13258" modified="2019-04-10" version="1">MSMYQSLIPSDARRAECERVCREHPEQLPVVVESANSSHVRFLAVPRDATVADLEAEVRQTLGTTNKKVALAIEGCSPAATTVVGDIFDACKQVDGFLYVSCAREPSMGAKDFCCFGNTGKYFADIENNPNLLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKL8</accession>
    <name>A0A3Q8IKL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPR repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TPR repeat/Tetratricopeptide repeat, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TPR_repeat/Tetratricopeptide_repeat_putative/Pfam:PF13414/Pfam:PF07719/Pfam:PF00515/Pfam:PF13428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_28870</name>
        <name evidence="5" type="ORF">LdCL_360027600</name>
        <name evidence="6" type="ORF">LDHU3_36.2840</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKL8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2840"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF513">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="330" mass="36255" checksum="1465B1F73164EF00" modified="2019-04-10" version="1">MTEKPAKEPPLPRDLKAQFDVLAGTRWDSVGDDADAAEHLSQLRHDWKTLGNACYGKGYFLAAIRCYSRLLEVPGGDTAQIRSNRSAAYLQSPMLVGPSLALKDAEKAVELEPKWFKAHLRVGDAHRKRGHFAEAEAAYREALALQPECATALAGLRALQVESADLPAAAATFPRGHAERAPYHNASPSPKPISSRTTAHAAAAAQAKEEELQLTQEQLVHKWKADISTREGRTGCRPRQASLSQADRQQGAAVKQALLARFRAKLESNGEFSATLRDRCEEAMLRGEGVNYRDADKLRNTYSHATNGIGLGISSDAYKEYTGRVDHRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INQ4</accession>
    <accession>E9BHZ9</accession>
    <name>A0A3Q8INQ4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AGC family serine/threonine kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">AGC_family_serine/threonine_kinase_putative/GeneD B:LmjF.25.2340</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Serine/threonine-protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_252450</name>
        <name evidence="11" type="ORF">LdCL_250030300</name>
        <name evidence="12" type="ORF">LDHU3_25.2930</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861575.1">
        <property type="nucleotide sequence ID" value="XM_003861527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INQ4"/>
    <dbReference type="SMR" id="A0A3Q8INQ4"/>
    <dbReference type="GeneID" id="13388821"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2930"/>
    <dbReference type="OMA" id="PFAKFNS"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000757">
        <property type="entry name" value="AGC family serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000636">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="46"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5430822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="389" mass="44400" checksum="29D82C0846EC3315" modified="2019-04-10" version="1">MFMKLFKKKDKKDKEDDKKSESTPTLENKRVETPEPPQEKLTKDDFETLDVLGKGSFAYVVLCRRLSTNKYYAMKVINKQGLLDHKRVQDVFTERNVLTRLNHPYLLKLYWTFQSEHKLFFVMDYMPGGDLDKYMNSVPKKQLDPATAQLYGAEILLAIMCLHEHSVIYRDLKPENILLDGEGHCALADFGLSKDFHKDGQDVSDKDLRANSFVGSPFYVAPDVLRQREYTNAVDFWSFGILLYRMLCGRTPFNGRSMTEVFDNILYSDLSFPSGVTVSPEAKDLISRLLMKDPNRRIKGPEVKQHPYWTGISFEEVAQRKVAPPRWTPLPSVEEMLAARKNVSAGPSTSLKNPHQVVNTPAQSSQLNDGQQRLFGGFSCTADSHLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INS4</accession>
    <name>A0A3Q8INS4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340044900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INS4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340044900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5800"/>
    <dbReference type="OrthoDB" id="264011at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="517" mass="55415" checksum="552C9DD15E005434" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INU3</accession>
    <name>A0A3Q8INU3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L7 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">60S_ribosomal_protein_L7_putative/GeneDB:LmjF.26. 0170/GeneDB:LmjF.26.0180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_4665</name>
        <name evidence="9" type="ORF">CGC21_31490</name>
        <name evidence="6" type="ORF">LdCL_260007000</name>
        <name evidence="7" type="ORF">LDHU3_26.0230</name>
        <name evidence="8" type="ORF">LDHU3_26.0240</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INU3"/>
    <dbReference type="SMR" id="A0A3Q8INU3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0240"/>
    <dbReference type="OrthoDB" id="276123at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5430853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP41067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP51916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="252" mass="28874" checksum="DBED4CA09C198804" modified="2019-04-10" version="1">MTTHSVYGNASDMPAVPAPESAIKRAAFKQQQTENFKKAVVARKAAKAALKKTAYLRARKYSREYRGAEKKLVTLRRQAASHGNYYLEAKPKVAVVTRIRGIAKVNPKQRKILQLLRLRQIFNTVFVKMNKPMENMLRAVEPYIAYGYPSLATVRAMVYKRGYLKINGQRVKITDNQMIKDKYNNADIVCAEDMVNQIYTCGKHFRTVTHGMWPFKLAPPAGGMRQKRRHFVEGGDYGNRDTLINRFLARMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQY6</accession>
    <accession>E9BTT5</accession>
    <name>A0A3Q8IQY6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_13420</name>
        <name evidence="11" type="ORF">LDBPK_362260</name>
        <name evidence="10" type="ORF">LdCL_360028300</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865341.1">
        <property type="nucleotide sequence ID" value="XM_003865293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQY6"/>
    <dbReference type="GeneID" id="13388227"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2940"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="321"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP48334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="571" mass="63015" checksum="3E99F3A152AA3593" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IR86</accession>
    <accession>E9BU50</accession>
    <name>A0A3Q8IR86_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_13990</name>
        <name evidence="4" type="ORF">LDBPK_363410</name>
        <name evidence="3" type="ORF">LdCL_360040900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865456.1">
        <property type="nucleotide sequence ID" value="XM_003865408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IR86"/>
    <dbReference type="GeneID" id="13388342"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4670"/>
    <dbReference type="OMA" id="SAQDWAH"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="515" mass="56132" checksum="F3FD7003998E3DA2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IU22</accession>
    <accession>E9BQB2</accession>
    <name>A0A3Q8IU22_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein_kinase_putative/GeneDB:LmjF.33.1710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_10555</name>
        <name evidence="13" type="ORF">CGC21_37730</name>
        <name evidence="12" type="ORF">LDBPK_331810</name>
        <name evidence="10" type="ORF">LdCL_330024900</name>
        <name evidence="11" type="ORF">LDHU3_33.2700</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864007.1">
        <property type="nucleotide sequence ID" value="XM_003863959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IU22"/>
    <dbReference type="SMR" id="A0A3Q8IU22"/>
    <dbReference type="GeneID" id="13392402"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2700"/>
    <dbReference type="OMA" id="WFAMHAP"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000491">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001513">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5433384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP53695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP55517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="640" mass="72291" checksum="B0CD66355424B905" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IUC2</accession>
    <name>A0A3Q8IUC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340007000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IUC2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0290"/>
    <dbReference type="OrthoDB" id="265920at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="623" mass="65515" checksum="04FAB02D4FFE1447" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4T7</accession>
    <accession>E9B783</accession>
    <name>A0A3S5H4T7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_18005</name>
        <name evidence="4" type="ORF">LDBPK_010190</name>
        <name evidence="3" type="ORF">LdCL_010006900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000041">
        <property type="protein sequence ID" value="TPP54559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857832.1">
        <property type="nucleotide sequence ID" value="XM_003857784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4T7"/>
    <dbReference type="GeneID" id="13389758"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0210"/>
    <dbReference type="OMA" id="RECGELY"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CWF21" evidence="2">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="207" mass="22610" checksum="F7E6BEBF3B2F1863" modified="2019-04-10" version="1">MYNGVEAAAVKGTGLSGYVQRSRVNVLATGRVPAEEGAAAMEGGASINPLEQRRAQGENREMAARLESHRALREVRLRVMLYREEREAAGVDPVTMDRECGELYDSLLVAAKRRLKAQQKTENAKTVAKFAAAFGVKATAAVTTSGGGAGSGSAFDRSVQEVEKHRTEEERRRHQEAQLVEHLKRMRREGSDAVEGANIWDTEETGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Z1</accession>
    <name>A0A3S5H4Z1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_020007600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4Z1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0320"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF7">
        <property type="entry name" value="GLYCOSYLTRANSFERASE (GLCNAC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1145" mass="123380" checksum="84725692BE3C14D8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5I6</accession>
    <accession>E9B8E7</accession>
    <name>A0A3S5H5I6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_9520</name>
        <name evidence="3" type="ORF">LDBPK_050570</name>
        <name evidence="2" type="ORF">LdCL_050010800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858244.1">
        <property type="nucleotide sequence ID" value="XM_003858196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5I6"/>
    <dbReference type="GeneID" id="13391297"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0650"/>
    <dbReference type="OMA" id="CSHRFIR"/>
    <dbReference type="OrthoDB" id="10256706at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="410" mass="46603" checksum="41E58800D64A2EF5" modified="2019-04-10" version="1">MRTGTSARAPFTHGVAGRAIKTRVKSNLGQPYAQRFYNNVWTYRVAQLTTSNVRSMKKARIAVGFDSGVGGGHSGGASSQDGNDGSGSGAELPVKSDLQPHALHKFAGEEDWSIVIAVPKSSEHVRNLQDCAKGSLMLGHTDPQLFHWFKELGALPPRSLLSGPMELLRGDLQVEAWERTFSRHPVIHRIAQDMWESDESKTAEEAVHIAKREQEEDEKRMRRMSSSDWRAKFRDRERNPTRAEDEEAPVYVIKPETFSLFRMKPDVRLWMNIAGQTQRVWDPVVPDPDPLCRCSHRFIRMLNLGRQKLVPSLNMNYSLKLTNAFIFEINDRGMWAMGTQENLAGKNGVVREEWMELRLDFGKNQVITTEQEMEWWVRGLTKLGAPELSQTNSSVEDAGLNPEDFEYRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5M8</accession>
    <accession>E9B8L7</accession>
    <name>A0A3S5H5M8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_20320</name>
        <name evidence="5" type="ORF">LDBPK_060060</name>
        <name evidence="3" type="ORF">LdCL_060005500</name>
        <name evidence="4" type="ORF">LDHU3_06.0090</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000054">
        <property type="protein sequence ID" value="TPP49822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858314.1">
        <property type="nucleotide sequence ID" value="XM_003858266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5M8"/>
    <dbReference type="GeneID" id="13391641"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0090"/>
    <dbReference type="OMA" id="AYECAQW"/>
    <dbReference type="OrthoDB" id="264651at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="322" mass="36016" checksum="8A8B83FA6920990B" modified="2019-04-10" version="1">MNSTLGSSGSAGDEAPLVGGLDALTLRTINEQQLIILRQKELVSTLKERVEELEAQPWRADVKPLEAAHKADGRKGTLSYVSEMQLRRRVKTLEDENKKLSDLVDELRAEVSTISAQLYAQQLHTQSEKDVWKAKARNAEAKSVATAHLLEATDKRNQQLIHHLEKLRREGEVSAYECAQWRSLATTTASHLDHANRRYARDQINSIEEDVHRYAVNRLRLARVAPSASLSLESETPEETRKMWSRSAQLPKFDPAPQVFQQQQQESVCSQLHVSHQRPLSQLLPCQPPQPTASHSLAPPASKHVNAETHPSPSHCAALAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5N2</accession>
    <accession>E9B8M3</accession>
    <name>A0A3S5H5N2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_20290</name>
        <name evidence="9" type="ORF">CGC20_21705</name>
        <name evidence="11" type="ORF">CGC21_24495</name>
        <name evidence="8" type="ORF">LDBPK_060120</name>
        <name evidence="6" type="ORF">LdCL_060006100</name>
        <name evidence="7" type="ORF">LDHU3_06.0160</name>
    </gene>
    <organism evidence="6 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2015-01" db="PDB data bank">
            <title>Characterization and prediction of thermal stability of cyclophilin mutants from L.donovani.</title>
            <authorList>
                <person name="Roy S."/>
                <person name="Datta A.K."/>
                <person name="Banerjee R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 22-187</scope>
    </reference>
    <reference evidence="6 13" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000055">
        <property type="protein sequence ID" value="TPP43951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000054">
        <property type="protein sequence ID" value="TPP49816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858320.1">
        <property type="nucleotide sequence ID" value="XM_003858272.1"/>
    </dbReference>
    <dbReference type="PDB" id="4S1J">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B=22-187"/>
    </dbReference>
    <dbReference type="PDBsum" id="4S1J"/>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5N2"/>
    <dbReference type="SMR" id="A0A3S5H5N2"/>
    <dbReference type="GeneID" id="13391647"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0160"/>
    <dbReference type="OMA" id="SVWGQVI"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044516126" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5427392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP43951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP49816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP54892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="4S1J"/>
        </source>
    </evidence>
    <sequence length="187" mass="20412" checksum="A2F2B8C313110E5C" modified="2019-04-10" version="1">MRFVAVLAVVLCALSFLNVAAEPEVTAKVYFDVMIDSEPLGRITIGLFGKDAPLTTENFRQLCTGEHGFGYKDSIFHRVIPNFMIQGGDFTNFDGTGGKSIYGEKFADENLKVKHFVGALSMANAGPNTNGSQFFITTAPTPWLDGRHVVFGKVLDGMDVVLRIEKTKTNSHDRPVKPVKIVASGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5R7</accession>
    <name>A0A3S5H5R7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060011900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5R7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0800"/>
    <dbReference type="OrthoDB" id="267346at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="679" mass="70950" checksum="D595580771D68B0F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6D3</accession>
    <name>A0A3S5H6D3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090010200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090501.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0640"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2 C-terminal" evidence="2">
        <location>
            <begin position="2002"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1818"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2078"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2149"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2495"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2735"/>
            <end position="2792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2149"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2509"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2750"/>
            <end position="2763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2938" mass="304911" checksum="DB131FCB51265201" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6E3</accession>
    <name>A0A3S5H6E3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Surface antigen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_090016800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6E3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1290"/>
    <dbReference type="OrthoDB" id="268030at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018609394" description="Surface antigen-like protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="8975" checksum="9ADE18BE76F5F27A" modified="2019-04-10" version="1">MASTLNKFLLVLVALVVLATHAAAQSPPCSIKQCSECVAGSTTQCAICNPGYRLNAKGQCVTNVNAAAAPHVAVTAVAAVMTAVVAYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6M7</accession>
    <accession>E9BB67</accession>
    <name>A0A3S5H6M7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_18195</name>
        <name evidence="10" type="ORF">LDBPK_120850</name>
        <name evidence="9" type="ORF">LdCL_120020600</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000048">
        <property type="protein sequence ID" value="TPP49690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859204.1">
        <property type="nucleotide sequence ID" value="XM_003859156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6M7"/>
    <dbReference type="SMR" id="A0A3S5H6M7"/>
    <dbReference type="GeneID" id="13390435"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1650"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="167"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP49690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="343" mass="39251" checksum="D108D9DFA138788C" modified="2019-04-10" version="1">MSSAKQCEEAAAEGTVVKTTANKDYYFDSYSHYGIHMEMLKDYHRTTAYRDAIWRNAYMFKNKVVLDVGCGTGILSMFAARAGARKVIGIDCSNVAVQARRIVQDNGFSDVITIIQGKVEELDLDEKVDIIISEWMGYFLLYESMLNTVLYARDRWGTPDVKILPNSANMYACGITDPQYIEQKFDIWKNVNGLDFSYFKRLSYIEPLIDTVDPEQIITDIVPFFSFDINKVTEAELSFTRTFALEAKQGDFVHAISVHFDTPFHAGHDPVVLNTSPMVPPTHWRQTVLYIFHPLIMKRGEKADFTIKCVPNPGNPRDLDISLRIDFDGELQACHYDQDFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Z2</accession>
    <accession>E9BD15</accession>
    <name>A0A3S5H6Z2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CGC21_24615</name>
        <name evidence="19" type="ORF">LDBPK_161640</name>
        <name evidence="18" type="ORF">LdCL_160021400</name>
    </gene>
    <organism evidence="18 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18 22" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 22">LdCL</strain>
        </source>
    </reference>
    <reference evidence="23" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase alpha in a complex with DNA primase is a replicative polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859848.1">
        <property type="nucleotide sequence ID" value="XM_003859800.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A3S5H6Z2"/>
    <dbReference type="GeneID" id="13393165"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1960"/>
    <dbReference type="OMA" id="MTKMNVG"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000187">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000005">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="370"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="678"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYU77741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP51091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1340" mass="150522" checksum="4607DB2C4866641C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H748</accession>
    <accession>E9BE01</accession>
    <name>A0A3S5H748_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CGC20_9295</name>
        <name evidence="20" type="ORF">CGC20_9300</name>
        <name evidence="21" type="ORF">CGC20_9305</name>
        <name evidence="22" type="ORF">CGC21_19565</name>
        <name evidence="23" type="ORF">CGC21_19570</name>
        <name evidence="24" type="ORF">CGC21_19575</name>
        <name evidence="18" type="ORF">LDBPK_190040</name>
        <name evidence="12" type="ORF">LdCL_190005200</name>
        <name evidence="13" type="ORF">LdCL_190005300</name>
        <name evidence="14" type="ORF">LdCL_190005400</name>
        <name evidence="15" type="ORF">LDHU3_19.0030</name>
        <name evidence="16" type="ORF">LDHU3_19.0040</name>
        <name evidence="17" type="ORF">LDHU3_19.0050</name>
    </gene>
    <organism evidence="14 26">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 25" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 26" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 26">LdCL</strain>
        </source>
    </reference>
    <reference evidence="28" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="27" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860184.1">
        <property type="nucleotide sequence ID" value="XM_003860136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H748"/>
    <dbReference type="SMR" id="A0A3S5H748"/>
    <dbReference type="GeneID" id="13385996"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0050"/>
    <dbReference type="OMA" id="PLVCHIS"/>
    <dbReference type="OrthoDB" id="3360192at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000043">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU78102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5429388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5429389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAC5429390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP41874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TPP51062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP51063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP51064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="107" mass="11861" checksum="065E2C3C902049E8" modified="2019-04-10" version="1">MASSRKASNPHKSHRKPKRTWNVYVGRSLKAINAQMSMSHRTMKIVNSYVNDVMERICTEAASIVRANKKRTLGAREVQTAVRIVLPAELAKHAMAEGTKAVSSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7A5</accession>
    <accession>E9BFN0</accession>
    <name>A0A3S5H7A5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32860</name>
        <name evidence="3" type="ORF">LDBPK_220110</name>
        <name evidence="2" type="ORF">LdCL_220007200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860761.1">
        <property type="nucleotide sequence ID" value="XM_003860713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7A5"/>
    <dbReference type="GeneID" id="13389326"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0380"/>
    <dbReference type="OMA" id="PMEDGNA"/>
    <dbReference type="OrthoDB" id="265402at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="329" mass="33639" checksum="D43515ACF38F7EEE" modified="2019-04-10" version="1">MSAHSTEEHGVLLPGIQSQRHEQGAQQQTEPDASSVPTEMRFGQAASLSPAAKRYRLEKQARKEVTADATSVIDLNEDADVESAARVSATVALQDDLASPADALLGGADGSVDVSGSTFCVEADVTGVSDETLTGFDRATGPACAEKGAATPSVHEQETLRHKQPPQAMPYTECEDTPAQPLPMEDGNAAAPPVCLSIDEEGAVASPPSALAVTPAHLSQADKKTASGVTALNSGTLGGNSAPRCHAEGEVSSATEAEPTTDNVATTKIPSPIPEDGENGCLPPSRLSEAATPPPSVAAVDERPKAAGKHLTFADDAAPQPSMARSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQX3</accession>
    <accession>E9BA22</accession>
    <name>A0A3S7WQX3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPPDE putative peptidase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">PPPDE putative peptidase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">PPPDE_putative_peptidase_domain_containing_protei n_putative/Pfam:PF05903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_7855</name>
        <name evidence="9" type="ORF">CGC21_36710</name>
        <name evidence="8" type="ORF">LDBPK_091370</name>
        <name evidence="6" type="ORF">LdCL_090020100</name>
        <name evidence="7" type="ORF">LDHU3_09.1620</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858815.1">
        <property type="nucleotide sequence ID" value="XM_003858767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQX3"/>
    <dbReference type="SMR" id="A0A3S7WQX3"/>
    <dbReference type="GeneID" id="13392163"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1620"/>
    <dbReference type="OMA" id="HNCIDFA"/>
    <dbReference type="OrthoDB" id="262626at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="37"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5427926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="254" mass="28250" checksum="854ADC250105DBFA" modified="2019-05-08" version="1">MDGASADGGDGAPASAERHSLKPLMWIEEVRDASQPNAVFLNVYDVSGSSTLLCSVGWGVHHVGVQVYGKEYQYGHRPIGKGIGSVKPRHSPPHTYREQFFLGQTQLSAFEVEKLVVAFSEKVEWLGNNYHLVKHNCIDFARAFCEALLPPAVRVEQARRAEEAGLPQKMHMVEVEVDGMRHSVPVLIPHHVDRLARYAAHYLPKSSMRSFDRLESSFFSMSEVPQERGQPTAADPNANRSTTPTPQPRTRTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WR50</accession>
    <accession>E9BAA6</accession>
    <name>A0A3S7WR50_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc binding dehydrogenase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zinc_binding_dehydrogenase-like_protein/GeneDB:Lm jF.10.0560</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_100610</name>
        <name evidence="2" type="ORF">LdCL_100012900</name>
        <name evidence="3" type="ORF">LDHU3_10.0930</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858897.1">
        <property type="nucleotide sequence ID" value="XM_003858849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WR50"/>
    <dbReference type="SMR" id="A0A3S7WR50"/>
    <dbReference type="GeneID" id="13392224"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0930"/>
    <dbReference type="OMA" id="CGRIACL"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08271">
        <property type="entry name" value="MDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001131">
        <property type="entry name" value="Zinc-binding dehydrogenase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="27"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="371" mass="39527" checksum="F5661C995058BA9C" modified="2019-05-08" version="1">MSGQAGKQVAPVKCKGWSVEKPALQWSTDAVRLSDVTVPAPGPTQIRVRVYAASINPVDWKRVMFPASGSGPGVAGSALKGFKGMHHKPPNYPYPYVVGVDGAGEVESVGGKVTGLKAGDRVMFHSSLTNAHGGSLCEYAVMEESVAVPIPADGARPFSYEEAAAIPCATWTAYVALFDKLRIEPGRSIFVDGASGAVGSCAVQLAHHMGLYVFASCSPSNADYVRSIGADQVLNYHDGIEMIDQILDATEGYGVDYYLAVTNTQDAESFTDALRFGGAVCLLSGVLIPNSNVLFRRQLSVHYVFLNGLHGHPLTRPQLRYIGDQVAKLYQSGAFRLDVEVLPFAEAAKALDRSATGNVNHKKLIVQVASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSC2</accession>
    <name>A0A3S7WSC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_120021200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSC2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1710"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="971" mass="106396" checksum="AB73826E65C683D9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSJ9</accession>
    <accession>E9BBG4</accession>
    <name>A0A3S7WSJ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_17145</name>
        <name evidence="6" type="ORF">CGC21_33385</name>
        <name evidence="5" type="ORF">LDBPK_130900</name>
        <name evidence="3" type="ORF">LdCL_130014400</name>
        <name evidence="4" type="ORF">LDHU3_13.1120</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859301.1">
        <property type="nucleotide sequence ID" value="XM_003859253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSJ9"/>
    <dbReference type="GeneID" id="13390491"/>
    <dbReference type="KEGG" id="ldo:LDBPK_130900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1120"/>
    <dbReference type="OMA" id="INCNDVL"/>
    <dbReference type="OrthoDB" id="273180at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP50082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="327" mass="36013" checksum="B301B598073ED9E5" modified="2019-05-08" version="1">MRYRQCQHHFTDRDQQAKALINCNDVLSTSEQEEVIAYFARSLRGSAQLLKVVVCLQAMLALVYTLLLLSGSLLIDVSVDMAAAASLVQLAQQHKQGSPEPATAALELTAPSQTLVEALAALDAEQRAAQRKYVHEYMNRRTAAGVNVRSGGAVTLLSALVVLYSIALLLWAGYSCYVACRRLTVNVEDLTRTEPRDLHRRRPEEGPSAEAPAAKPRGALRHLRRRVKTDPAVALYAAAAFASLGSLFWVAALVHRQRTTQRAYADLGLQPPSVLSLQSITNAALEYVLAVWQPLFHLGIGLLVRSMLDTRDNLVALSKLKYRFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV65</accession>
    <name>A0A3S7WV65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Qb-SNARE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_190005000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV65"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0010"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="295" mass="33872" checksum="35A21A3DB50C05F5" modified="2019-05-08" version="1">MAGAKDEKESRDISGDPFQDLTNDFVRAATRAKNNINERNEGCRQHGQDHMAIVQSNEIRKDLRLMEETLEEIHKLVLEAERRLAKENKKKKPKENKVHLLERDYEGRRSQYDNCVSALQNLKEMEAQRVELRREEINTVQEMQLGKRAQLRQQLLGMRRKDNGNGETVGPGDVELVDNTLGGGMLQEHEESKEQMKTIAAQDAKIDAGLCRIKEGVGRLHDLAVQIGAQIDMQNAMLDETEQVIDKNAEQLRGLNRRLKKFLKETRPMNCFLYVCCVFLIIALIGFFLVQFNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV69</accession>
    <accession>E9BE14</accession>
    <name>A0A3S7WV69_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helix-turn-helix family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Multiprotein-bridging factor 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Multiprotein-bridging_factor_1_putative/GeneDB:Lm jF.19.0190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_9230</name>
        <name evidence="10" type="ORF">CGC21_19500</name>
        <name evidence="8" type="ORF">LDBPK_190180</name>
        <name evidence="6" type="ORF">LdCL_190006800</name>
        <name evidence="7" type="ORF">LDHU3_19.0190</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860197.1">
        <property type="nucleotide sequence ID" value="XM_003860149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV69"/>
    <dbReference type="SMR" id="A0A3S7WV69"/>
    <dbReference type="GeneID" id="13386009"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0190"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5429404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP41861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP51049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="163" mass="18389" checksum="4AE2CA0D19E08078" modified="2019-05-08" version="1">MPRGAIPTGQDWEEQRFNFQQRGGGGSAQPRKVTERDANRAVQSGQNVQVQRKEHQRFNQQAVSAGANAKKLDEDNETLKVKKVDPHLRVRIMKERQALNWSQQDLAQRISERVSVVAEYESGKAVQEERVIVKMEKALGVHLRGAKAGEPMGKTRPTPKPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXA4</accession>
    <name>A0A3S7WXA4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'a2rel-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220013900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1100"/>
    <dbReference type="OrthoDB" id="267920at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1428"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1428"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1613" mass="166508" checksum="C913C35740ED9E74" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXD7</accession>
    <accession>E9BFY4</accession>
    <name>A0A3S7WXD7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_221190</name>
        <name evidence="8" type="ORF">LdCL_220019000</name>
        <name evidence="9" type="ORF">LDHU3_22.1720</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860865.1">
        <property type="nucleotide sequence ID" value="XM_003860817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXD7"/>
    <dbReference type="GeneID" id="13389588"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1720"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000018">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5430097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="511" mass="58694" checksum="41E775A7A240FE97" modified="2019-05-08" version="1">MVHPAEGGVEVGSTGAGAAAAVFCGGRSGVPSVVSSQNDITSEARLDQIVAVLEEKRVERQRKMFEDMIVFEGGAVSDHPSLGTRLIMRDFVHFALYNNKWGYYPKLFRKYRQLMTTGYFDPIPFASLRNQHDYERYATKLHESTPGFVTPTQLFQPYYGWVLAEYLVTTHRAKFDPREPLIVYDIGAGTGALALSVLDYLAEHFPDLYAACEYHAVEQNPHLIQVLRNKLIHHYHHVNIHHLSVLNWRQLEKRRCVVLAVELFSGMPHDCVLWDQEAVVSEHWFGFQQHDNLATAHERYYALQDPIILRYLRYLNWMQEESFHNLKVLCLTEGRETLDAPNRRSIEPNMADSTIAIFTKMAYIMSPFHTAWLPTVQMVFLEMLAQYFPRHHLFAADWSSVRQALPGVNGPVLQVKLRVAKDMYLRKPVDALHANAGMVDMCFPTDFDHLSIVYARICGAQKEVESMRHPVFWQTHGGDKTALFTTRSGYNPLLEDFQQFHVFTSHHSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXF3</accession>
    <name>A0A3S7WXF3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pentamidine resistance protein 1</fullName>
            <ecNumber evidence="13">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_230007300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="13"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0300"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="962"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="261"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="657"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1562" mass="172209" checksum="EB556A18FEF88BB5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXI8</accession>
    <name>A0A3S7WXI8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230009900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0640"/>
    <dbReference type="OrthoDB" id="273476at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1921"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1921"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1944"/>
            <end position="1953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1983" mass="213170" checksum="43E2ABC97781A59F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ51</accession>
    <name>A0A3S7WZ51_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NPL4 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NPL4 family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NPL4_family_putative/Pfam:PF05021</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_26605</name>
        <name evidence="5" type="ORF">CGC21_8710</name>
        <name evidence="3" type="ORF">LdCL_250018800</name>
        <name evidence="4" type="ORF">LDHU3_25.1650</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ51"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1650"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000121">
        <property type="entry name" value="NPL4 family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore localisation protein NPL4 C-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP48902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="427" mass="47268" checksum="2C3BFBBFBD9C21A4" modified="2019-05-08" version="1">MSANDSLGLLREEQRRRFEAAKREGNTPEVRKCDACQQPTYSANVCPASGLFHDLDKKKLIGGSVVTSNVISSSQLMAAIDQTRVKWVPSRTQLVKVDAQSINIFQSFVAQMDWKLQRYAILYGLYDDATHTIEVHAVYEPEQHGSTYTFEPLPDAHLDKVEKIAKALGLRRVGVACTHPMRDPEHILLNFRELLLCAKEQSRYGDECALLTVAPAAMPSTKSGGTTSAPGELPTGSAAASSGPTLEPTIVVSCQAWQTSPQCVHLYRLGVLQESSGGEAALQDVEQARQVHCTMALEVAQTDTDPRGHQRFVTKAPSTEIDTRWFTSYIAVQQFESPIVRGAFMRLSRPGMPPPVLQNLRNYIRDPKRKSMSFAETIADFHVLVYLLTQIFTSDDELRALCSVARTKMMTEEAANYQAILLGMMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZN2</accession>
    <accession>E9BI66</accession>
    <name>A0A3S7WZN2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_31660</name>
        <name evidence="4" type="ORF">LDBPK_260530</name>
        <name evidence="3" type="ORF">LdCL_260011000</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861641.1">
        <property type="nucleotide sequence ID" value="XM_003861593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZN2"/>
    <dbReference type="GeneID" id="13388887"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0700"/>
    <dbReference type="OMA" id="NQVFYDR"/>
    <dbReference type="OrthoDB" id="273566at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="702" mass="74104" checksum="C940BD59E008838A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X093</accession>
    <name>A0A3S7X093_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_5735</name>
        <name evidence="4" type="ORF">CGC21_32575</name>
        <name evidence="2" type="ORF">LdCL_260032000</name>
        <name evidence="3" type="ORF">LDHU3_26.3380</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP52130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X093"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3380"/>
    <dbReference type="OrthoDB" id="250921at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="151" mass="17131" checksum="668B5000E797D4A0" modified="2019-05-08" version="1">MSSIAAKQVHRQQLLQPRLALPAGRTVSLEEGRRLAKFAHDEEDRLQSEATRLLEVKEASPVVLEENVSRRILLLRQKQNSKANVKAAVAYANRLHRKSAVQAEDVTKMREAASRVLRPSSSIGSASLKQRRQRAEQTKKQRQPKQGKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0B7</accession>
    <accession>E9BIU8</accession>
    <name>A0A3S7X0B7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WW domain/Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">WW_domain/Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_ similar)_putative/Pfam:PF00397/Pfam:PF00642</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_270130</name>
        <name evidence="9" type="ORF">LdCL_270006200</name>
        <name evidence="10" type="ORF">LDHU3_27.0170</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861871.1">
        <property type="nucleotide sequence ID" value="XM_003861823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0B7"/>
    <dbReference type="GeneID" id="13389132"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0170"/>
    <dbReference type="OMA" id="PPTAYES"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5431124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16944" checksum="828EE1E004F32039" modified="2019-05-08" version="1">MSPPADCVPRRQHRVLSPLSPQSKIIILLTNSTSIKMQQAYFGQQPMLPPGWQLSYTADGKPYYIDHNTKTTHWSIPPTAYEPYYNNGRGRGAGYRGGRQGIDRTKMKSKMCIYWEKNGNCAWGDRCAFAHGAEELRNPASQPRNDAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0C7</accession>
    <name>A0A3S7X0C7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetoplast-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_270007300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270007300"/>
    <dbReference type="OrthoDB" id="10691969at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1597"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1616" mass="175339" checksum="5E7F52D1334B5347" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0R8</accession>
    <accession>E9BJ74</accession>
    <name>A0A3S7X0R8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_30705</name>
        <name evidence="3" type="ORF">LDBPK_271420</name>
        <name evidence="2" type="ORF">LdCL_270021000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861995.1">
        <property type="nucleotide sequence ID" value="XM_003861947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0R8"/>
    <dbReference type="GeneID" id="13386729"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2160"/>
    <dbReference type="OMA" id="AAYYTQP"/>
    <dbReference type="OrthoDB" id="272026at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="743" mass="79683" checksum="52F6516787438466" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0V2</accession>
    <name>A0A3S7X0V2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_270025000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0V2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2740"/>
    <dbReference type="OrthoDB" id="244508at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="532" mass="58211" checksum="82EAEEC81B53A3A5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1L6</accession>
    <name>A0A3S7X1L6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_280024500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1L6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2560"/>
    <dbReference type="OrthoDB" id="276744at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16561">
        <property type="entry name" value="RING-HC_RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="512"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="961"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="883"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1265" mass="136599" checksum="18CDAABD8B18A67C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X216</accession>
    <accession>E9BK31</accession>
    <name>A0A3S7X216_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_22975</name>
        <name evidence="3" type="ORF">LDBPK_283150</name>
        <name evidence="1" type="ORF">LdCL_280036800</name>
        <name evidence="2" type="ORF">LDHU3_28.4200</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862409.1">
        <property type="nucleotide sequence ID" value="XM_003862361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X216"/>
    <dbReference type="GeneID" id="13387145"/>
    <dbReference type="KEGG" id="ldo:LDBPK_283150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280036800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.4200"/>
    <dbReference type="OMA" id="RAPFIAN"/>
    <dbReference type="OrthoDB" id="271104at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP54436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="179" mass="19422" checksum="0ED621A646565A52" modified="2019-05-08" version="1">MESYETDASLEQLPKGVEFPELVLRCTVVAAIPLRICEFGDDKVFTVVGSVAPCTPGACAATKMRLLRINFYNSWGAAAAFMDPGDVILLRGFCLLDVPPHTSGGGAARSASEPQLLFVRPLPSKSTLRVLQKGGKELVMEVAVSPENWDAISMRSLPKSDAENQRYARTCWGLEELSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3F6</accession>
    <accession>E9BLP6</accession>
    <name>A0A3S7X3F6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA pseudouridylate synthase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA_pseudouridylate_synthase_putative/Pfam:PF0084 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_301530</name>
        <name evidence="3" type="ORF">LdCL_300020700</name>
        <name evidence="4" type="ORF">LDHU3_30.2010</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862866.1">
        <property type="nucleotide sequence ID" value="XM_003862818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3F6"/>
    <dbReference type="GeneID" id="13385573"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2010"/>
    <dbReference type="OMA" id="EWTEFVA"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49515" checksum="B46053C018A4E281" modified="2019-05-08" version="1">MLVLSKPPGIRMDGDETIYGRTVESLVCEHMKARGIFDDTHEQLQKEKKRKKQLKFVHQLDFGTSGVLCLAFTKDMAARLAHCFEMRTVRKYYVALLHGHLPSDTAPTEDGASSDQPGSTFTSDTKARRSSFAAWANACNKAWEGLGCVRAVCSASTSGESSANSAGGDEVAGFRYLLQRPRKTAWEAVGLANSKDAEEGVPVTVVHRYHSRRSGAPSLSTSAPENPASVPADVVEDLIYRTLLESTATRSVVFVDLPVGYDLTGPEHLRMAVTAEQSRDAKTSLLVLKRTYLAEPPPAGGEAPQRDAIAKDSPSVTSYPVTLVLLAPHTGRRHQLRVHCRAIGFPIVGDTSYCADLPWCAALPLGSSTSTWAAAGARRMYLHAWRLLLPGTVTPRLDEVERVALKKKRRREILGLSGQHDASFSASRCEWTEFVASVDFTGLDLEDSEDREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3U0</accession>
    <accession>E9BM66</accession>
    <name>A0A3S7X3U0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="6">HMG-CoA reductase</shortName>
            <ecNumber evidence="6">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_303230</name>
        <name evidence="7" type="ORF">LdCL_300037900</name>
        <name evidence="8" type="ORF">LDHU3_30.4320</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="6"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863034.1">
        <property type="nucleotide sequence ID" value="XM_003862986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3U0"/>
    <dbReference type="SMR" id="A0A3S7X3U0"/>
    <dbReference type="GeneID" id="13385743"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4320"/>
    <dbReference type="OMA" id="VGRNIEN"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000003">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5432347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="434" mass="45861" checksum="81071FF196F09FFE" modified="2019-05-08" version="1">MRRSLLLACSAAKGGSWASMPDAEIMKQVENKKIAFYGLEQALAPDYDRAIAIRREIVKKKMCPSTAATHPLERVPYKNYDWSSVVGQSCENILGYVPVPVGLAGPLLLDGKEVALPMATTEGALVASAHRGARAINLSGGCRTAVLKEGMTRAPVVEVNSFDEAITVIKFCEERFDVLKEAFESTTRFGKLLSIKCAMAGRQVHMRFSAFTGDAMGMNMITKGCDKALQVLQQHIPSVRVLTLSGNFCTDKKPSALNWVEGRGKSVVAEAVIKRDVVEGVLKCTVDSVVSLNVTKNLRGSALAGSIGGFNAHAANIVAALYIATGQDPAQIVESATCMTTVDKAGEDLVISLTMPSIEVGAVGGGTGLSSQRAMLELMGCAGSNKEDPGANSRQIARVVAGAVICGELSLLSGLAAGHLLSAHMKLNRKPPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4E7</accession>
    <name>A0A3S7X4E7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310019600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4E7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2090"/>
    <dbReference type="OrthoDB" id="266181at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1090" mass="117252" checksum="64B96861518F119F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X515</accession>
    <accession>E9BN92</accession>
    <name>A0A3S7X515_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">DnaJ domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_10695</name>
        <name evidence="4" type="ORF">LDBPK_313220</name>
        <name evidence="3" type="ORF">LdCL_310040500</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863406.1">
        <property type="nucleotide sequence ID" value="XM_003863358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X515"/>
    <dbReference type="SMR" id="A0A3S7X515"/>
    <dbReference type="GeneID" id="13389978"/>
    <dbReference type="KEGG" id="ldo:LDBPK_313220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310040500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5480"/>
    <dbReference type="OMA" id="RFFMIGC"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000210">
        <property type="entry name" value="DnaJ domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="217" mass="24241" checksum="8A4569E8A6AA3285" modified="2019-05-08" version="1">MLRLSRRLLGAAGAGPFDPYKILGVKPDATKDEIKKAYHRLALRFHPDSGAEGNAARFAAVNEAYEAVKDGKWKYSAQQQQKAEEQNRGGWRDPKMRMYVYEQPGSTTDGYVSGDTEKYMRFFMIGCFLFIFVRVSLFFLLPVTRNGGRHETVLDQERSDGCLPLDAVGNQETPFEQSLANAANGCSSGSVHADEEVEYKWAEGGASTHLKDPLSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X589</accession>
    <accession>E9BNG2</accession>
    <name>A0A3S7X589_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_33605</name>
        <name evidence="4" type="ORF">CGC21_19850</name>
        <name evidence="3" type="ORF">LDBPK_320580</name>
        <name evidence="1" type="ORF">LdCL_320011300</name>
        <name evidence="2" type="ORF">LDHU3_32.0730</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863476.1">
        <property type="nucleotide sequence ID" value="XM_003863428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X589"/>
    <dbReference type="SMR" id="A0A3S7X589"/>
    <dbReference type="GeneID" id="13390288"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0730"/>
    <dbReference type="OMA" id="FERCKPH"/>
    <dbReference type="OrthoDB" id="268421at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="113" mass="12744" checksum="5C8C9116D4CF6AD4" modified="2019-05-08" version="1">MGGKTAFDDVCANEAKAWSICLETNLGGKDVRKKCSVQQQTFDTCVSAWRAKVGQAVQVKGENEGDPPFQCASMSCHIGECLRKYNYDFDRCKPHTQFFKYCVKSFYGQDYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X618</accession>
    <accession>E9BPA6</accession>
    <name>A0A3S7X618_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LDBPK_323560</name>
        <name evidence="17" type="ORF">LdCL_320041500</name>
        <name evidence="18" type="ORF">LDHU3_32.4500</name>
    </gene>
    <organism evidence="17 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17 21" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863767.1">
        <property type="nucleotide sequence ID" value="XM_003863719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X618"/>
    <dbReference type="GeneID" id="13391293"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320041500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4500"/>
    <dbReference type="OMA" id="ECVASRY"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="461"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU81906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAC5433113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ37084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="809" mass="87457" checksum="E32A515C981C0A19" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X699</accession>
    <accession>E9BPV5</accession>
    <name>A0A3S7X699_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase, N-terminal domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Thiol-dependent reductase 1</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Thiol-dependent_reductase_1/GeneDB:LmjF.33.0240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_11340</name>
        <name evidence="6" type="ORF">CGC21_38490</name>
        <name evidence="5" type="ORF">LDBPK_330260</name>
        <name evidence="3" type="ORF">LdCL_330007500</name>
        <name evidence="4" type="ORF">LDHU3_33.0310</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863850.1">
        <property type="nucleotide sequence ID" value="XM_003863802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X699"/>
    <dbReference type="SMR" id="A0A3S7X699"/>
    <dbReference type="GeneID" id="13392247"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0310"/>
    <dbReference type="OMA" id="EFICATR"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000563">
        <property type="entry name" value="Thiol-dependent reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041695">
        <property type="entry name" value="GST_C_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16865">
        <property type="entry name" value="GST_C_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5433204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ37167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP55674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="450" mass="49927" checksum="6E47E385DE8B102A" modified="2019-05-08" version="1">MAARALKLYVSATCPFCHRVEIVAREKQVSYDRVAVGLREEMPQWYKQINPRETVPTLEVGNADKRFMFESMLIAQYLDNSGAPAGALMGSSAAQRHQIEFFLAQVGDFIGAAHGLLRDPLSGEKRKAMDDNAAYVDGLLAANQTTGPYYCDGEFTMADVALVPFLVRLKPALMYYAGYDVFCKAPRMKALWAAAAQRASVRETSPTAAQCIENYRHLVPESAPMMGANGGHVLYSNLFCPFVDRARLASELRKFQMHIVEVPLHPQPEWYKYINPRDTVPALFTPSGEAVHESQLIVQYIDCVATKGSALVPRGDAEKEYEVGFFVENAGYFVGGLMSWIIRGGEDAKAELQWAAGELEQQLAKHPFGEGPFFGGKRMNAGDVAILPFLVRAKAFMPEFSGGYDLFAHFPLLNGLAEAGMATPEAKSVFRTLEEYKEHIRKRQRRAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6F0</accession>
    <name>A0A3S7X6F0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330010900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0800"/>
    <dbReference type="OrthoDB" id="263256at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF31">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1454" mass="156550" checksum="DBCD3B0E9A16C5B4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7K2</accession>
    <name>A0A3S7X7K2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_340013800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7K2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1330"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="304" mass="34636" checksum="DF76547D067B73DC" modified="2019-05-08" version="1">MASSTSPSSSTVPQTLIEKLLTVRGASAQRQVLIKEEEIRAVLRAVREVFMSQPMLLEIRPPVRVCGDTHGQYYDLLRIYEKCGFPPYSNYLFLGDYVDRGKQSVETIVLQFCYKIVYPENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLTDLTAINEILRPCDVPDRGILCDLLWADPENEVRGFLESDRGVSYLFGEDIVNDFLDMVDMDLIVRAHQVVQRGYEFFASRQLVTVFSAPNYCGEFDNDAAVMTIDDKLQCSFLIIPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7V9</accession>
    <name>A0A3S7X7V9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340025900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7V9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3130"/>
    <dbReference type="OrthoDB" id="261620at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="316" mass="34928" checksum="2A4B7643A1FABDE8" modified="2019-05-08" version="1">MAVVVFDMGALESWKLRLRELANAGDGCKEHVLSCLDALEHLGRTAEHDSVLPVPRNNLETDLAVINAAPYTRVSTGTQLWTVHPIHYTHHVLNKMMRERQVQRLTRRLGNLAADLHSVAHDMWKVLQASCIRQTSTTSQRLSDVTRVTTLDRPASVATAPGSMNGASPALSPSTCRTLRSLFGRFPDFEADVLLHGSSLNASSEATTETSATPPHARKQVDASVQTPPEFTAESTAVDTPRERLLFLCRRCRQDGRAGYQVDKNRMQLKQTHDIVASVERTEPPPPLKSPTLQCTVSRGARPPLPQIGGTRRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7W0</accession>
    <name>A0A3S7X7W0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p25-alpha family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">p25-alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_1685</name>
        <name evidence="2" type="ORF">LdCL_340022600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7W0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2470"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP50363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="142" mass="15431" checksum="7237562DE9212547" modified="2019-05-08" version="1">MDNSHFSKMLKECKIIGKSFTSTDADLLFSKVKAKEARKISFTEFKEKAIPEIAAKMKKTPADIEAMIANAAPKSSGTKADTVRFHDDKSTYTGAAKQGGPTNVDRNAGSLAGVVDRRQETIDNRGTTAYKNVKHQTASTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X866</accession>
    <accession>E9BR82</accession>
    <name>A0A3S7X866_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rhodanese-like domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Rhodanese-like domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_26705</name>
        <name evidence="14" type="ORF">LDBPK_342840</name>
        <name evidence="13" type="ORF">LdCL_340036500</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CEP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864443.1">
        <property type="nucleotide sequence ID" value="XM_003864395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X866"/>
    <dbReference type="GeneID" id="13392852"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4850"/>
    <dbReference type="OMA" id="EECHIIT"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000123">
        <property type="entry name" value="Rhodanese-like domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051889">
        <property type="entry name" value="CEP41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44390:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 41 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ37761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP40187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="249" mass="28254" checksum="62E32E82452803BD" modified="2019-05-08" version="1">MSINPTIGDKDILQRRTSANPKYDSVQAVVESGMTAQLAEYMRNIKIKTKRQPGELFQRLRVDVIAAFLSRQEPKSVLEDGGFARPMDEYGGPENAVDKAAISYLLIDCREVEHYEACHIKTALHYPKIKVHHSTNPFLPEMYAYKNKENRYIVLYDMEEEAVVNLANTMFQKGIDNVAIIAGGLREFAQDYADFLTARPPVPIVPRDWRMKRRAEEATQARSEARTSMSHKPKGLSSSLARSSRKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9G8</accession>
    <accession>E9BSH8</accession>
    <name>A0A3S7X9G8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_7020</name>
        <name evidence="12" type="ORF">LDBPK_353080</name>
        <name evidence="11" type="ORF">LdCL_350035700</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864887.1">
        <property type="nucleotide sequence ID" value="XM_003864839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9G8"/>
    <dbReference type="GeneID" id="13387765"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350035700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3990"/>
    <dbReference type="OMA" id="IKREEAY"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP44571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="266" mass="30680" checksum="95C5CE2FC59B12E8" modified="2019-05-08" version="1">MSHSSARQQGAGEKEEIRRINRELQRNLILETALIAFALGVLALAGVLLAAHGWHTHNDSLFALGLYILAVHIAFHVLEFLVAAFTRPHDTHPDAFMVFHSIPYLIASGTALLEFFVEAYAIPERWKLDPTRHTLLGFFLRVNYTSALLFTFLVLVFYGIRVVSMLQCGSNFSLMIEHERHSGHQLVTHGLYRYLRHPAYFGWFWRTCCAQWILANPVSAVVHTGVTWYFFRYRIAYEEATLQRPDYFGEAYKRYKVRTIVGIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9Q5</accession>
    <accession>E9BSS0</accession>
    <name>A0A3S7X9Q5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PRP8 protein homologue, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">U5 snRNA-associated splicing factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">U5_snRNA-associated_splicing_factor/GeneDB:LmjF.3 5.3950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_354000</name>
        <name evidence="8" type="ORF">LdCL_350045100</name>
        <name evidence="9" type="ORF">LDHU3_35.5170</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864978.1">
        <property type="nucleotide sequence ID" value="XM_003864930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13387856"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350045100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5170"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000002">
        <property type="entry name" value="U5 snRNA-associated splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="7">
        <location>
            <begin position="2181"/>
            <end position="2313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2427" mass="277669" checksum="79770AB3F756A68B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9Y7</accession>
    <name>A0A3S7X9Y7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350049600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9Y7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350049600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5880"/>
    <dbReference type="OrthoDB" id="268066at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37541:SF1">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37541">
        <property type="entry name" value="SRP40_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="67453" checksum="33D12FD88601CE8C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB37</accession>
    <accession>E9BU15</accession>
    <name>A0A3S7XB37_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_13815</name>
        <name evidence="3" type="ORF">LDBPK_363060</name>
        <name evidence="2" type="ORF">LdCL_360037000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865421.1">
        <property type="nucleotide sequence ID" value="XM_003865373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XB37"/>
    <dbReference type="GeneID" id="13388307"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360037000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4230"/>
    <dbReference type="OMA" id="AEVIWPY"/>
    <dbReference type="OrthoDB" id="274820at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="346" mass="39270" checksum="BECC3DE2E6950DF8" modified="2019-05-08" version="1">MLSSAHSAAFARPTAALWTSARSFGAGPTRLLLGLEQVQDVPTSTDRKPTGMHRGPGKRQTAPKEAAQYQFIKKWDLQMREAWDELEPFKGLPKPKAQFGNEAAEVIWPYALLLENVIKVHPYTKSIYVYYSQRQSTPLGELAARVAKRVSQAYLIPITFHNSHVYVEAEMLLEYSETPWIVVHCLDGTHKLIPVKPQAGQTVKEGAEEVLNGIVSACNEIGNAVKNPKEVMRLLSERPLQNQYVRVNYQWYGDTPEERMSHLVKWDYEPEEVVPQLRNRTQHVLDWMNYDGNLPTHNSVRVNIRREAARMRKPNVSAGPKTFFNSSGSRANARTARFNNSRSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9B933</accession>
    <accession>A0A3S5H5W7</accession>
    <name>E9B933_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_070380</name>
        <name evidence="2" type="ORF">LdCL_070007300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858479.1">
        <property type="nucleotide sequence ID" value="XM_003858431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B933"/>
    <dbReference type="SMR" id="E9B933"/>
    <dbReference type="GeneID" id="13391861"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0290"/>
    <dbReference type="OMA" id="DEYGMAR"/>
    <dbReference type="OrthoDB" id="272657at2759"/>
    <dbReference type="PhylomeDB" id="E9B933"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="635" mass="67352" checksum="CCAB26F6C5241CBF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9B9K3</accession>
    <accession>A0A3S5H688</accession>
    <name>E9B9K3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative DUF1126 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_081030</name>
        <name evidence="9" type="ORF">LdCL_080015900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858662.1">
        <property type="nucleotide sequence ID" value="XM_003858614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B9K3"/>
    <dbReference type="GeneID" id="13391942"/>
    <dbReference type="KEGG" id="ldo:LDBPK_081030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1480"/>
    <dbReference type="OMA" id="MSEYGRY"/>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="PhylomeDB" id="E9B9K3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="279"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="8">
        <location>
            <begin position="476"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="869" mass="96750" checksum="EE95FE7A7DF2F320" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAU2</accession>
    <accession>A0A3Q8IBB5</accession>
    <name>E9BAU2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_111040</name>
        <name evidence="2" type="ORF">LdCL_110016200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859080.1">
        <property type="nucleotide sequence ID" value="XM_003859032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAU2"/>
    <dbReference type="GeneID" id="13389550"/>
    <dbReference type="KEGG" id="ldo:LDBPK_111040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1270"/>
    <dbReference type="OMA" id="EFFRFAQ"/>
    <dbReference type="OrthoDB" id="266877at2759"/>
    <dbReference type="PhylomeDB" id="E9BAU2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="814" mass="87194" checksum="AE2047BAC2F8C9B4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBR7</accession>
    <accession>A0A3S7WSV4</accession>
    <name>E9BBR7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_140320</name>
        <name evidence="10" type="ORF">LdCL_140008200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859404.1">
        <property type="nucleotide sequence ID" value="XM_003859356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBR7"/>
    <dbReference type="GeneID" id="13391096"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0410"/>
    <dbReference type="OMA" id="VIVQCEV"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="PhylomeDB" id="E9BBR7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000041">
        <property type="entry name" value="Amino acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826:SF7">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="POLYAMINE TRANSPORTER PUT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="765"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="803" mass="84846" checksum="93407C150887DA57" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCC2</accession>
    <accession>A0A3S7WTG4</accession>
    <name>E9BCC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_150820</name>
        <name evidence="2" type="ORF">LdCL_150013700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859606.1">
        <property type="nucleotide sequence ID" value="XM_003859558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCC2"/>
    <dbReference type="GeneID" id="13392946"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1070"/>
    <dbReference type="OMA" id="RCAIRAK"/>
    <dbReference type="OrthoDB" id="270454at2759"/>
    <dbReference type="PhylomeDB" id="E9BCC2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="655" mass="71928" checksum="C294E13BB705BD5B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCR0</accession>
    <accession>A0A3S7WTV2</accession>
    <name>E9BCR0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_160570</name>
        <name evidence="2" type="ORF">LdCL_160010600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859744.1">
        <property type="nucleotide sequence ID" value="XM_003859696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCR0"/>
    <dbReference type="GeneID" id="13393112"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0680"/>
    <dbReference type="OMA" id="FYYEFRY"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="PhylomeDB" id="E9BCR0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="734" mass="78367" checksum="B2A0F5F15DCD5C2A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE03</accession>
    <accession>A0A3Q8IA51</accession>
    <name>E9BE03_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_190070</name>
        <name evidence="3" type="ORF">LdCL_190005700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860186.1">
        <property type="nucleotide sequence ID" value="XM_003860138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BE03"/>
    <dbReference type="GeneID" id="13385998"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0080"/>
    <dbReference type="OMA" id="QAYKLKA"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="E9BE03"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="432" mass="50936" checksum="D30BE5CA9B693E1B" modified="2011-04-05" version="1">MDKQDYYTILGISRTANKDAIRQAYKLKALQLHPDKNPNGEAIFKLVVNAYQTLNDPTKRSAYDRELTRRDRGFGAHQFRQAAPQPSSPAAYPSSSYGADAGASRKPRYATDEQLFKDAYEQYKKSPFSATPDGGFRGVNSEGTFAEWFKKKQEELRRAEEVTKAKAEYAKNLEREEKRRAEEWRDMQRRREEEREEEVRQAKDQREREREMLRRKREAEAKEQKEAEKKAQMEAYAEVQREQQADVERHLRDLASQKRELAEERRRLAEERAEVTNLAAEHRFTRDMAHKQRGQELADAVRRADAKVREAQEQQMLHEANERAKAEERAREEKLKRAEEERALEAERARERQRQKEAEAAEQERNRTTAELGEQRKRVIAQMMSERRRHEEEVSAMRRETDRIEAEMKAKLEALRAAKNSGQTINLDEWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEB6</accession>
    <accession>A0A3S5H767</accession>
    <name>E9BEB6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_191240</name>
        <name evidence="16" type="ORF">LdCL_190017500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860299.1">
        <property type="nucleotide sequence ID" value="XM_003860251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEB6"/>
    <dbReference type="GeneID" id="13386111"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1500"/>
    <dbReference type="OMA" id="VGCYPCL"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="PhylomeDB" id="E9BEB6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="15">
        <location>
            <begin position="222"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU78224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="461" mass="50567" checksum="6BADFA83F26C9E61" modified="2011-04-05" version="1">MFESNLLSQINTSSPLPTVVEVQFTTSINQTLYKAFQFAHTLLAEKSDRAAVLLPWSDEIYLALSGMMERLMLEHADTTFSEMIFALRRAEVDGPLAAAPPLSSSSAAASGPSSPGLRPGARGRYLRWLLLGPPPVTTPEERAMNFINDGVSSQLRVHASAPADAAVAAIVSPDMATPTPLMDAGATDSTAAVGSAADAAALSQLKSVELLKAEHAPYGYLRFKTLSRRNKVISLLLLTLKPYLERKAEQWYVRNTDTSVDAVAMRNAYAYRYPHRAALLHFLAKYVYPIYHVMKQGSRFLYMMCFLLEMTPYTSPLHRVFGIALRRSTLEDSLATGPRAQRALLVARVVLILVFCGFRLLDFTRNADGASSPRQIREEGLPIPPPPVLGSDVPLPEDRSSLPKAGECPVCRRHVTNAAVCLISGIVGCYPCLQGYVQEQRACPVTHQSMGVEQIRRVFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BF57</accession>
    <accession>A0A3Q8IBU2</accession>
    <name>E9BF57_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_210720</name>
        <name evidence="9" type="ORF">LdCL_210012100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860589.1">
        <property type="nucleotide sequence ID" value="XM_003860541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BF57"/>
    <dbReference type="SMR" id="E9BF57"/>
    <dbReference type="GeneID" id="13386402"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0780"/>
    <dbReference type="OMA" id="EMDCQVG"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="PhylomeDB" id="E9BF57"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002726">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF34">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="327" mass="34793" checksum="EEEB586FB92D19C1" modified="2011-04-05" version="1">MATAQNANPECVGPESPQAGIAPSCQGCPNAAICASAPKGPDPDIPLIRERLAGVKHKVMVVSGKGGVGKSTMTKELAFALGARGLSVGLMDMDICGPSLPRLTGVRGEDAHQSAGGIEPVLVDENVTMMSMHYLLSNKNEAVLFRGPRKNGVIKMFLKDVIWGNLDVLLIDTPPGTSDEHITVNSLLQQTTNGVDGAVLITTPQRVAEADVRREVNFCQKAKLPILGLVENMSGFVCPGCHKESQIFPKEEGREGRKEGAGVRLSREFDVPLWGEVPLDPLLMKACEEGISFSEYVEKSGMTSSTTLDALFTVADQLIASLGIQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIB1</accession>
    <accession>A0A3Q8IDR0</accession>
    <name>E9BIB1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_260990</name>
        <name evidence="1" type="ORF">LdCL_260015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861686.1">
        <property type="nucleotide sequence ID" value="XM_003861638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIB1"/>
    <dbReference type="GeneID" id="13388932"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1260"/>
    <dbReference type="OMA" id="VQMEIQD"/>
    <dbReference type="OrthoDB" id="260785at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7277" checksum="EB79C17850A495B0" modified="2011-04-05" version="1">MSSTFTALDDLEREMNTYLNDTQATGCGDIGPVLFHSARVQMEIQDLSQRVQQKSIALEDRARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJK7</accession>
    <accession>A0A3S7X1F4</accession>
    <name>E9BJK7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BILBO1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_281360</name>
        <name evidence="3" type="ORF">LdCL_280018200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862235.1">
        <property type="nucleotide sequence ID" value="XM_003862187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJK7"/>
    <dbReference type="GeneID" id="13386971"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1720"/>
    <dbReference type="OMA" id="CEPFTIN"/>
    <dbReference type="OrthoDB" id="271919at2759"/>
    <dbReference type="PhylomeDB" id="E9BJK7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.650">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49211" checksum="DD7CBE3A48F6BA7C" modified="2011-04-05" version="1">MSFTLMACTDIRGQKVNVELPFEQPPSSMEALRSTLEHLFRREEEAIKYSMGYTDMRACEPFTINRLQRYDDDSQSWADVTSIDVLQTYDQLYLFRKNSTKADISTQRELPPPRMSEFFYDPAAPGPFHTPCGSSRVNENGTAAALAPTSGGYGGTASPSQARPSAGSSPYRVGGASDSATAAQPPESPPEADPYQASAPPPTSAAALPTPPPSSSFYYKERTTPERVEYLFSLGSQHNDSVALTEKAFEHIFRMASVAFPVEVLQDLFDHFATRGDGGVGTATMSQVGFQEFATYFPVLVNIAYQRITNRNREEAIRAAQLDNAKQVKHARRQLQELEARLEAARKEVQQAEQHEARLQEDLYDISMQRDPEYCQDEQKLLDKEVSVFKYRERLSREERDYERLAIERRKRAVAASARARSHSPQGAYDRNRYGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJP0</accession>
    <accession>A0A3S7X1K0</accession>
    <name>E9BJP0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_281690</name>
        <name evidence="2" type="ORF">LdCL_280021600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862268.1">
        <property type="nucleotide sequence ID" value="XM_003862220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJP0"/>
    <dbReference type="GeneID" id="13387004"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2180"/>
    <dbReference type="OMA" id="YRKGPWR"/>
    <dbReference type="OrthoDB" id="267065at2759"/>
    <dbReference type="PhylomeDB" id="E9BJP0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="561" mass="59511" checksum="AD55EE36401C91A4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKU6</accession>
    <accession>A0A3Q8IEB3</accession>
    <name>E9BKU6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_291480</name>
        <name evidence="6" type="ORF">LdCL_290020300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862567.1">
        <property type="nucleotide sequence ID" value="XM_003862519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13387303"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2160"/>
    <dbReference type="OMA" id="KRVTVQW"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="PhylomeDB" id="E9BKU6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="257"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="878"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1385" mass="140504" checksum="6CDC53440D497255" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>H2ALR9</accession>
    <accession>E9BTH8</accession>
    <name>H2ALR9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ch36-1190 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ch36-1190</name>
        <name evidence="2" type="ORF">LDBPK_361190</name>
        <name evidence="1" type="ORF">LdCL_360017000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="thesis" date="2010" institute="London School of Hygiene &amp; Tropical Medicine">
            <title>Sudanese Leishmania donovani: Population structure and recombination uncovered by multilocus microsatellite typing (MLMT), multilocus sequence typing (MLST) and DNA quantitation.</title>
            <authorList>
                <person name="Baleela R.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MHOM/IN/80/DD8</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Baleela R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MHOM/IN/80/DD8</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE648224">
        <property type="protein sequence ID" value="CCF23222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865235.1">
        <property type="nucleotide sequence ID" value="XM_003865187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H2ALR9"/>
    <dbReference type="GeneID" id="13388120"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360017000"/>
    <dbReference type="OMA" id="LPKKHRC"/>
    <dbReference type="OrthoDB" id="271835at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF23222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="455" mass="49546" checksum="573CDF0489946CDF" modified="2012-03-21" version="1">MQSYHRHMTLSSNPVVVFVFDHQGSAVTNFWAPLMQSVSKGFDAFGIEVAHAPTSSEIGQQLLGAMNAGSGGPIILFFQGVGDTPAEGGKALKMPIAYEGNIDIAHIMSWGLSCISSSVTHRVHNDVDLARFFAQYPQYPTLPHVLYFPSTSYTPGGYLALSQHFALDAVFGVVPNAFAAANATLIAQRYNITSKDELPVLLVLHRAAADDGGGAGESDHVVRMPATATSLSYREALAFLSTHITDTVAALVAKAESTQNQHFLEVAESRRVYMMGQLIERQLDIAEEERLQMAREPILVKDQAAWAKECVQLPKKHRCLAAFVDSAQDSAAKDNAVKVLALVSVKLLEIMGREAQKVSLVVVDRQGSDAVREYFDVGHNGFPDVLFLSLDRPAKYYNFVGTFSAEGVTQFIAAHDAQLTHKDVRGGHTFIPRMVPKLEEAVAVTRGSDEDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>O60994</accession>
    <accession>E9BCT2</accession>
    <name>O60994_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8 10">Chitinase</fullName>
            <ecNumber evidence="9">3.2.1.14</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Glycosyl hydrolases 18 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Chi-1</name>
        <name evidence="12" type="ORF">CGC20_36620</name>
        <name evidence="13" type="ORF">CGC21_24970</name>
        <name evidence="11" type="ORF">LDBPK_160790</name>
        <name evidence="9" type="ORF">LdCL_160013200</name>
        <name evidence="10" type="ORF">LDHU3_16.0950</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="1997-06" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization and expression of a gene encoding the chitinase of Leishmania donovani.</title>
            <authorList>
                <person name="Shakarian A.M."/>
                <person name="Dwyer D.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="9"/>
    <dbReference type="EMBL" id="AF009354">
        <property type="protein sequence ID" value="AAC17944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC6551">
        <property type="entry name" value="JC6551"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859766.1">
        <property type="nucleotide sequence ID" value="XM_003859718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O60994"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="13393184"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0950"/>
    <dbReference type="OMA" id="SGIMIWE"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044737514" evidence="6">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="60"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC17944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5428941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP51162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="457" mass="50454" checksum="EC68AE4329AD9D45" modified="1998-08-01" version="1">MVQRSALLQLACLVAVLHSSCLSALLSSTIAAAAPAAARDTAISSRHNTPITAASPSPLFTVFGYLPEYRRGTFNYEAFFKAGLTHLIFFSAEVDPATLRLIHVEDRLPSGDEWARIRRLADLHGVKLMLCIGGGGRSAGFADLVGDTVQRQAFIEEVNAVLLARKLDGIDFNWEYPQTMTEWLNFGRFLMELRSSLGYAAAAGGEHAAGPIGERRHRTRVRGAALSMALHPHPSMAAVLQSARVLHSLDYVHLMAYDHVVGTGPHSSVEYAASVLSEETIGLFNEAAYNRRLGQMHRRPRTEQDHRRKLTLGIPFYGRHREDRRLQPEAYDRLWLFIQEWASKNHPTWVEGGAELRALSEYDGYSFTGYDDVKRKMQLTRAANLSGIMIWELGQDVPPGTSPMSLMTAVHEQLADWGLLTDGGRGSGGNVNSDNAYDRPQPPPQHSSPDVAEDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q71S88</accession>
    <accession>E9BNU4</accession>
    <name>Q71S88_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FeSODB1</name>
        <name evidence="15" type="ORF">CGC20_34255</name>
        <name evidence="14" type="ORF">CGC21_20505</name>
        <name evidence="13" type="ORF">LDBPK_321910</name>
        <name evidence="11" type="ORF">LdCL_320024600</name>
        <name evidence="12" type="ORF">LDHU3_32.2410</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="5910" last="5920">
            <title>Iron superoxide dismutases targeted to the glycosomes of Leishmania chagasi are important for survival.</title>
            <authorList>
                <person name="Plewes K.A."/>
                <person name="Barr S.D."/>
                <person name="Gedamu L."/>
            </authorList>
            <dbReference type="PubMed" id="14500512"/>
            <dbReference type="DOI" id="10.1128/IAI.71.10.5910-5920.2003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2006-09" db="EMBL/GenBank/DDBJ databases">
            <title>Genetic fingerprinting and identification of differentially expressed genes in isolates of Leishmania donovani from Indian patients of post kala-azar dermal Leishmaniasis.</title>
            <authorList>
                <person name="Venkat Subbaraju B."/>
                <person name="Singh R."/>
                <person name="Sreenivas G."/>
                <person name="Salotra P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2008" name="Parasitology" volume="135" first="23" last="32">
            <title>Genetic fingerprinting and identification of differentially expressed genes in isolates of Leishmania donovani from Indian patients of post-kala-azar dermal leishmaniasis.</title>
            <authorList>
                <person name="Subba Raju B.V."/>
                <person name="Singh R."/>
                <person name="Sreenivas G."/>
                <person name="Singh S."/>
                <person name="Salotra P."/>
            </authorList>
            <dbReference type="PubMed" id="17761024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 16" key="4">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="10">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="11">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="AF312585">
        <property type="protein sequence ID" value="AAQ14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EF032817">
        <property type="protein sequence ID" value="ABK51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863607.1">
        <property type="nucleotide sequence ID" value="XM_003863559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q71S88"/>
    <dbReference type="SMR" id="Q71S88"/>
    <dbReference type="GeneID" id="13390657"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2410"/>
    <dbReference type="OMA" id="DSLINWD"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAQ14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABK51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5432946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ36922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP43702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP47196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="195" mass="21527" checksum="705F2EB32E3A4227" modified="2004-07-05" version="1">MPFAVQPLPYPHDALASKGMSKEQVTFHHEKHHKGYAVKLNAAAESNSGLASKSLVDIIKSEKGPAFNCAAQIFNHDFFWRCLSPRGGGEPSGPLASAIVDSFGSFASFKKEFTDAANGHFGSGWAWLVKDKSSGKLKVLQTHDAGCPLTEPNLVPILTCDIWEHAYYIDYRNDRASYVNAFWNMVDWDFASSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I980</accession>
    <accession>E9BCH8</accession>
    <name>A0A3Q8I980_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-GTPase-TBC domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_1305</name>
        <name evidence="3" type="ORF">LDBPK_151390</name>
        <name evidence="2" type="ORF">LdCL_150019200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859662.1">
        <property type="nucleotide sequence ID" value="XM_003859614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I980"/>
    <dbReference type="GeneID" id="13392970"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1710"/>
    <dbReference type="OMA" id="TPCALWL"/>
    <dbReference type="OrthoDB" id="10249775at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="704" mass="77479" checksum="52ADEFB8EAC43DBF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9A9</accession>
    <accession>E9BCM8</accession>
    <name>A0A3Q8I9A9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein tyrosine phosphatase PRL-1</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_36355</name>
        <name evidence="17" type="ORF">CGC21_25235</name>
        <name evidence="15" type="ORF">LDBPK_160240</name>
        <name evidence="13" type="ORF">LdCL_160007300</name>
        <name evidence="14" type="ORF">LDHU3_16.0290</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859712.1">
        <property type="nucleotide sequence ID" value="XM_003859664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9A9"/>
    <dbReference type="SMR" id="A0A3Q8I9A9"/>
    <dbReference type="GeneID" id="13393077"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0290"/>
    <dbReference type="OMA" id="GIEVHSW"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000086">
        <property type="entry name" value="Protein tyrosine phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5428882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP40920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP51215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="175" mass="19432" checksum="2832F45BA3B82948" modified="2019-04-10" version="1">MEVNATLIDCCDPQRPSRVLFHFLILDAPSPSNLPTYIKELQHRGVRHLVRVCGPTYDATLVKSRGIEVHSWPFDDGAPPTRAVLDSWLKLLDTELARQQEDPSVPPPTIGVHCVAGLGRAPILVALALVEYGNVSALDAIALIREKRRGAINQTQMHWITKYKRRHQGGGCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA89</accession>
    <accession>E9BE73</accession>
    <name>A0A3Q8IA89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_8935</name>
        <name evidence="6" type="ORF">CGC21_19200</name>
        <name evidence="4" type="ORF">LDBPK_190780</name>
        <name evidence="2" type="ORF">LdCL_190012800</name>
        <name evidence="3" type="ORF">LDHU3_19.0860</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860256.1">
        <property type="nucleotide sequence ID" value="XM_003860208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA89"/>
    <dbReference type="GeneID" id="13386068"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0860"/>
    <dbReference type="OMA" id="DKWRTRN"/>
    <dbReference type="OrthoDB" id="276603at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="252" mass="29462" checksum="5F56A70AAA54E11C" modified="2019-04-10" version="1">MELGQTQRPRAPVEPFQEYEPRRKCTVCCGLRCAAFVGTTTFCVSLVCNAVVLGGRVTDGRGWRGFLNRNGLIALPAAAITFTHQVLLSESLWSKNKKTVTQVNTLSALSNMSLWAIGTVLCTTTARRYLPARSRAYRLALWEYHRARRGCANPWMPTIFGRVTEDLDWYNVMWTLTLYHLLWGMVSVMLEKELGSHYAMFYRNWQYSRWCSPRWREWRELEVRRHVDTEQAVAPNRWGTFITNDKWRTRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAH5</accession>
    <name>A0A3Q8IAH5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_31835</name>
        <name evidence="10" type="ORF">LdCL_200009600</name>
        <name evidence="11" type="ORF">LDHU3_20.0580</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAH5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0580"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000457">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5429606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="372" mass="41573" checksum="5AB65AE7BE9EA5F5" modified="2019-04-10" version="1">MLGGRHFQRKYEKKQKKKEAKKASQGPLRGAGGSSSASATAAAGAAAKRKDGSTLKGPVVSHGAFMASRDSANNRKNVPFPSKMEEKVYRKEHRVPKYNCIVDPERQNLAKAAGASSAAQRRRVLRQKGDEDLLDHFRERLNASTFRLLNEQVYNAPTTLASRLLREEATFRDYHTGYHQQLMQWPMNPSTLIVESLLGDRRGRFLANKGKSMPGHIPVSWVVADMGCGEAQIAAALKPKGYTVHSFDFFALNSLVTVADTTKVPLADNYVDVCVFSLSLMATDYVKSLFEAFRILKPKRLLKIIEVRSRVPFPRKFAELVEDIGFEVDYSDVAGDYFVAFDFIKKDDQAAANTQLRHEPGDVLVPSLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAL4</accession>
    <name>A0A3Q8IAL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAj-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200016200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAL4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1420"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000596">
        <property type="entry name" value="Putative DNAj-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000597">
        <property type="entry name" value="Putative DNAj-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="653" mass="74549" checksum="CE543E498987440A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBA8</accession>
    <name>A0A3Q8IBA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinesin, putative</fullName>
            <ecNumber evidence="7">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_190012000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0780"/>
    <dbReference type="OrthoDB" id="267092at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000135">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="637"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1588"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2102"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2182"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="782"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="928"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1649"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1713"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1803"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1936"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1596"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2137"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2228" mass="243128" checksum="3E3360A221E57127" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBD6</accession>
    <name>A0A3Q8IBD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor EIF-2b alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120005000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBD6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0030"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000023">
        <property type="entry name" value="Translation initiation factor EIF-2b alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="301" mass="33485" checksum="D57089DC4A357488" modified="2019-04-10" version="1">MDVPSEDYDVSIMIQAIHEVQDVLTSRQFATFSEVDTEIGKTLKRYEAFGDGFERFHVNLTKDALQSNDLQKSLKDMDKRCQDRLRDCASSQKDQINDILPFIRNTSSILVHGSGNLLALTIACSIQEHEGVRFYICEGRPARKGYPHGSGEQLLERVLATPEGMRLKDKLHNYCRIVPDSGVSSVMNNVDFVIMGAYCVTEHGGLVHSTGSLQIAIVAAFRNVPCYVLCETFKFAHIFPLSTDDLKQPEDGAGEVVPLVEFVPPSMITLIFSEQGIMPPSAVADEMFRFHTAPSAPGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBE3</accession>
    <accession>E9BEE9</accession>
    <name>A0A3Q8IBE3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">LDBPK_191590</name>
        <name evidence="23" type="ORF">LdCL_190021700</name>
        <name evidence="24" type="ORF">LDHU3_19.1930</name>
    </gene>
    <organism evidence="23 27">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23 27" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 27">LdCL</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860332.1">
        <property type="nucleotide sequence ID" value="XM_003860284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBE3"/>
    <dbReference type="SMR" id="A0A3Q8IBE3"/>
    <dbReference type="GeneID" id="13386143"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1930"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000086">
        <property type="entry name" value="IMP dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0327">Glycosome</keyword>
    <keyword evidence="5 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="8 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="175"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="270"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="383"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="407"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00084116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AYU78266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAC5429550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CBZ33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="514" mass="55552" checksum="E251FCC1362D60E5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBK8</accession>
    <accession>E9BG13</accession>
    <name>A0A3Q8IBK8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_221480</name>
        <name evidence="15" type="ORF">LdCL_220022100</name>
        <name evidence="16" type="ORF">LDHU3_22.2130</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5430127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860894.1">
        <property type="nucleotide sequence ID" value="XM_003860846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBK8"/>
    <dbReference type="SMR" id="A0A3Q8IBK8"/>
    <dbReference type="GeneID" id="13389617"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2130"/>
    <dbReference type="OMA" id="HIREVWS"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU78864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5430127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37746" checksum="533B5D0662DA1966" modified="2019-04-10" version="1">MTSKHTPQPYTMTANTPAWNPETRLPSLSKSAMIRDVWADNLEEEFATIRSLIKDYPFVSLDTEFPGVVAKPVGSFKTTHEFYYQTLRCNVNLLKIIQLGITLLNDKGEVPEHCSTWQFNFRFSIKEDVYAQDSIELLRHGGINFDYFNDFGIEVTHFAELLISSGLVLNSNVRWLAFHAGYDFGYLIKVVCNKDLPEKEEEFLQTLHALFPSMFDLKYLLRFTDVSHSFGLDYLAESLKLRRFGTAHQAGSDSLLTGHCYFKLLRDSFGNTAPVANNGVLYGLSEDAASSVTPSSAQAVTQVNSNSHNFSSPIAYGNGGASSGTFPAAPLNSNMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC59</accession>
    <accession>E9BM09</accession>
    <name>A0A3Q8IC59_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_6500</name>
        <name evidence="4" type="ORF">CGC21_36045</name>
        <name evidence="2" type="ORF">LDBPK_302660</name>
        <name evidence="1" type="ORF">LdCL_300032200</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862977.1">
        <property type="nucleotide sequence ID" value="XM_003862929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC59"/>
    <dbReference type="SMR" id="A0A3Q8IC59"/>
    <dbReference type="GeneID" id="13385686"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3560"/>
    <dbReference type="OMA" id="HRDFKYE"/>
    <dbReference type="OrthoDB" id="243634at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="421" mass="47288" checksum="771D8627B50C9484" modified="2019-04-10" version="1">MRAVVSAVLQPSSAVGALRCQARLITRLYTSYFKGELFPNQLVRPLERLPRGVSLAAARKGQLAAAPSSSGPGKPATAASPEVVAWGDVDSTDLVHANEQSRAVAPQAGLAPRRPYVPLGEVAKMELQGDYLTEGGLHQEALEYYGVVAKAYELAYPKDHPQVAGIRLKLAGAFRRTGRLASSKTNCEAALQMLDNAVQPPLELIVEALFELGLTSEAMSDDAAGTVFEEAVALVDMFHNSGQSHKMLRLLPRLGRRFNLNFEEKFVYFSPFDYDRVFALADQCLERAEVFYQARNDRAGVMRVLQQRKELIDKKFFNMRDFAGRIHTMRGHWKRRAQVLTNAPTPDELLRYSPTIHQVYRDFKYELNAPIGREKEVQPGVNRVVHDMGNPYRRNGVRSQRMFRDAEKNFEKYIRADAFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICK6</accession>
    <name>A0A3Q8ICK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_260005900</name>
        <name evidence="2" type="ORF">LdCL_260006200</name>
        <name evidence="3" type="ORF">LdCL_260006500</name>
        <name evidence="4" type="ORF">LDHU3_26.0130</name>
        <name evidence="5" type="ORF">LDHU3_26.0170</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICK6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0170"/>
    <dbReference type="OrthoDB" id="257299at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="356" mass="40150" checksum="5512E380CCCF00BE" modified="2019-04-10" version="1">MGKKGSLQRFHAMPPRLSHPDALAVVDLAVNGVVVRLHLASRCLPCAYTVALPVEAVRADARRYNGFTELRFCVDVPQRSARCRGLFLALRLPWGTVHYLGPLTHNAPVSSARFVREVPSSVTLLVDVDWCAPVEVGAPLPCEMLLKEHVRTVIENDEFCGSIAAAHVQNLVRDLPFYDAAMQRFRNWSEYVIFFAECYRCWRIVQYEPEEHAALGLSSRTPAGEQRMVANCYVDDYARADVHRDRVKRRALQEFRDCLAARGVELSWPPRKDRKAEPFFNLSHKVLLKLGCERSFRTLNSVNYLHVLEGLRASHSVLFSELHPVQVDAAVSTDTSLELLLRRVTAAKQPPSPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDN6</accession>
    <name>A0A3Q8IDN6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial DNA ligase-like, putative</fullName>
            <ecNumber evidence="6">6.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_260018900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDN6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260018900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1640"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000032">
        <property type="entry name" value="Mitochondrial DNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF3">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="5">
        <location>
            <begin position="220"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="433" mass="48926" checksum="2102343C757740D5" modified="2019-04-10" version="1">MQTPSNVSPVCMKMAVWRCSHCLQEFEMVVGHFIDGGGVCPHCHSPQKKLDNVTVRNAQGELVTKKPQYVKAPRMIHSNYRSVLFANPHWESLNIQPMLAQRWELVADELMKSSSGESGTASDKHLLLASPKIDGIRCMIGYNEKLREVQFFSRGGIVLECCHGLVPQLLPLFEKDPTLMLDGELFAPECNFEQLNGLVRRLNKKSDPKIMEAQARLLEYFAFDIMYSAQLSSVSAPFDERYMLLKKLIPVCGAKRISNYVHDDTRKKVIRATHGGVATAAAANGQAVKIYHVPAAQVHPSDMEDVLNEACSQGFEGVMIRLPKFPYEHGKRSFGLLKYKQMHDAEFKIVGFVPGEGKFKSALGAFVCTTKDGKHFNTPPKVSCKHRIELWEHRREYLGKYLTVQYQELSSQNVPRFPIAKAIRGSEDKRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE66</accession>
    <name>A0A3Q8IE66_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_270020600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2120"/>
    <dbReference type="OrthoDB" id="273265at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050397">
        <property type="entry name" value="Env_Response_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567">
        <property type="entry name" value="CRP FAMILY TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24567:SF26">
        <property type="entry name" value="REGULATORY PROTEIN YEIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="536"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1347" mass="144360" checksum="E2358421BA87448F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IED7</accession>
    <accession>E9BJ55</accession>
    <name>A0A3Q8IED7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">arginine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC21_30810</name>
        <name evidence="16" type="ORF">LDBPK_271230</name>
        <name evidence="15" type="ORF">LdCL_270018800</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861976.1">
        <property type="nucleotide sequence ID" value="XM_003861928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IED7"/>
    <dbReference type="SMR" id="A0A3Q8IED7"/>
    <dbReference type="GeneID" id="13389238"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1910"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000008">
        <property type="entry name" value="Arginine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000010">
        <property type="entry name" value="Arginyl-tRNA synthetase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="13">
        <location>
            <begin position="577"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU80017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP47520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="692" mass="78199" checksum="51537A399A2B222D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFU1</accession>
    <name>A0A3Q8IFU1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300022700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFU1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2420"/>
    <dbReference type="OrthoDB" id="270585at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35186" checksum="2BBE81488636FD47" modified="2019-04-10" version="1">MNFAKGATPRKSLNSKRRNGAEKTTDVPKDAVKHSRTRVLHVSVTDDTQIVSIPRDQEDPFDVWAVYSHVVYATKKEQRFLKRSLQSRIHESIVQCSNLFPLTGNDQEGKQSTPTGNSSRRMNASFVSTLQAQGYGKSIAACAMCVLSVWPSLPVKNRPPLSTKVQRSFEALQAGTHLYVFNEKPNSPLLCDTALRLLHSIDRDEVSVTIFNATERTVIDGYIPLSFVVSLSFGLEPVERARHLNKTGTIKCSNGHQTTEETSKRAFTLHCSAPELFYVTFIAATQEDFNKWTCVIDYFVLLNSCYRAYLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG16</accession>
    <name>A0A3Q8IG16_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260028300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG16"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2950"/>
    <dbReference type="OrthoDB" id="247693at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="825" mass="88627" checksum="E5D447693C418CD0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGY6</accession>
    <accession>E9BTE4</accession>
    <name>A0A3Q8IGY6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_12750</name>
        <name evidence="4" type="ORF">LDBPK_360850</name>
        <name evidence="3" type="ORF">LdCL_360013500</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865201.1">
        <property type="nucleotide sequence ID" value="XM_003865153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGY6"/>
    <dbReference type="GeneID" id="13388087"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1120"/>
    <dbReference type="OMA" id="EMDAEVH"/>
    <dbReference type="OrthoDB" id="266112at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="561" mass="60436" checksum="91D65D3C38FE8245" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGZ6</accession>
    <accession>E9BK12</accession>
    <name>A0A3Q8IGZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_22855</name>
        <name evidence="2" type="ORF">LDBPK_282920</name>
        <name evidence="1" type="ORF">LdCL_280034300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862390.1">
        <property type="nucleotide sequence ID" value="XM_003862342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGZ6"/>
    <dbReference type="GeneID" id="13387126"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3910"/>
    <dbReference type="OrthoDB" id="272399at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP54412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="122" mass="12897" checksum="996BD3831AD98AEE" modified="2019-04-10" version="1">MNTTKEKVTINFNTSRFGVKVADGSFDPDTTIGEVHARLRKKLVKAKAMTVPVASGGLEGAAAIGNCTATSGSGATFIFVRNGTEAFIPAPEQTLQTLLDMYAAAPEARRLYVTIDPEVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHM5</accession>
    <name>A0A3Q8IHM5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_330031300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHM5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3470"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF53">
        <property type="entry name" value="UDP-ARABINOSE 4-EPIMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="391" mass="43575" checksum="F4CC0FD6899A3A7C" modified="2019-04-10" version="1">MRVLVCGGVGYIGTHFVRELLRYSPHDVIIADSLEATHGSDVHVDTEKNYAARNPGANLEEVKRSGYRFAKLEVGDVRDANFLEHVFTTHAPIDAVVHMCAHIVVPESVRDPLRYYDNNVVGMLRILQTMLKYKCDKLILSSTAALFGNPYARMKAGSTDEPDPMKPIQSNAKCMPESPYGTTKLVDEYMLKDCAAAYGIKSVCLRYFNACGADAEGDIGETHEPESHLIPLILRVPLADKINAYNAVHHPDRQKVNDYISIFGTDYPTPDGTCIRDYVHVKDLSSAHVRALDYLAKLTPDDKDKFFSTFNLGTSKGYSVREVIEAARRVTGHPIPEKEEKRRDGDPPVLVASGEEAAAALGWNLEYKSIDKIIDSAWKFHSKHPVGYELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIF6</accession>
    <name>A0A3Q8IIF6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
            <ecNumber evidence="10">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_340022700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="10"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIF6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340022700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2480"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000307">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="65"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="968"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116367" checksum="E1F1A9FBAD954143" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIG5</accession>
    <name>A0A3Q8IIG5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340042500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340042500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5490"/>
    <dbReference type="OrthoDB" id="272364at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1945" mass="215598" checksum="B5464FF0E93091A3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIK7</accession>
    <name>A0A3Q8IIK7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein heavy chain and region D6 of dynein motor/Ankyrin repeats (3 copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_350058900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIK7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350058900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7070"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000684">
        <property type="entry name" value="Dynein_heavy_chain_and_region_D6_of_dynein_motor/ Ankyrin_repeats_(3_copies)/Ankyrin_repeat_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="346" mass="38882" checksum="DAA10E99C3FB1A7D" modified="2019-04-10" version="1">MASRAIANFSADFSPLKYVERAVKNSDCRTPIIFVQQDGDPFQTVCYLAKKRDSAVWSFDVAQLQSMQNVADYIDVGINNGDWVYITNCDLVSESYFRDVARTLYKILPEPHLYPRREVFRCFFGVTMPFDLNAPVGLPFPPLFMHSSLVARPTATQGTKWSRIMPAEKTLFSAAALKHQQRREVGRESDSESDLDEGDRISGVIFYRAVERSRDIDQSTVTLAKHEMVQAVEAQDDPVMRRLVSSGEVDLSRKLKDGMTPLQYACCKQLTGSVRTLLSLGADPNAPRESDGRPPLFMSIDDMELAKMLVEGGANLFSKFEGHRTDTHPDTAPDVAAYLDKERKCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIN6</accession>
    <accession>E9BKP4</accession>
    <name>A0A3Q8IIN6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IPP transferase/Zinc-finger of C2H2 type, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">IPP_transferase/Zinc-finger_of_C2H2_type_putative /Pfam:PF01715/Pfam:PF12874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_290980</name>
        <name evidence="6" type="ORF">LdCL_290015000</name>
        <name evidence="7" type="ORF">LDHU3_29.1350</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862515.1">
        <property type="nucleotide sequence ID" value="XM_003862467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIN6"/>
    <dbReference type="SMR" id="A0A3Q8IIN6"/>
    <dbReference type="GeneID" id="13387253"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1350"/>
    <dbReference type="OMA" id="EECKICK"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003950">
        <property type="entry name" value="IPP transferase/Zinc-finger of C2H2 type, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="215" mass="24786" checksum="E12BAFC241F4CDDF" modified="2019-04-10" version="1">MEREVLDDFLNRRVDLMLQRGMLGEVKAFWLKNGRKLPHNSLSGAIGCKEFSQFFTSDNPSLISSSDCENAVAQIKSNTRRYARQQERWIQNRLLPLLHSSSLKEAPTHFVQLWVQEGVDALPSVQRTLDTFLGTSPVQPLAESLFPLKQQLASREPVSQKECKICKILVYGRGQMVIHLKSKRHRGSLRRLALEKEHREKYGRELPPPKRKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ22</accession>
    <name>A0A3Q8IJ22_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPR repeat/Pentatricopeptide repeat domain/PPR repeat family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360057600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ22"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360057600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6760"/>
    <dbReference type="OrthoDB" id="424777at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="278" mass="30869" checksum="C3C963D1ECDDF70F" modified="2019-04-10" version="1">MASLSAARVARFTSRWLTEELNSFARSGNWEGALQMFEHMQQSSLVRRNVFHYTTVLTACTRAGQMDAAMMVFRQMKANQVKPNVYTYTTLINGCANAKKLDLALRIFAEMRLVEVPPNVKTMTALISVCSRCGQWKKGLQVLDQCEEFFIAPNALTYTAAMDGCRRAGVCTPAIALLEARMTDPSQVRPNEVTYNTVLGACAAAKDHKAALRVYARMTADGYEPIEYTRELLREVFRGTSLDGLADNLKVRVKTSKWEAYVPDSDPATALRAAQEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJI6</accession>
    <name>A0A3Q8IJI6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_170019200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJI6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1810"/>
    <dbReference type="OrthoDB" id="248214at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="855" mass="90367" checksum="1BA41CCC8EC66784" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK79</accession>
    <accession>E9BED8</accession>
    <name>A0A3Q8IK79_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase-like protein</fullName>
            <ecNumber evidence="8">1.14.13.39</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Oxidoreductase-like_protein/GeneDB:LmjF.19.1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_191490</name>
        <name evidence="8" type="ORF">LdCL_190020700</name>
        <name evidence="9" type="ORF">LDHU3_19.1810</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="8"/>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860321.1">
        <property type="nucleotide sequence ID" value="XM_003860273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK79"/>
    <dbReference type="GeneID" id="13386133"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1810"/>
    <dbReference type="OMA" id="CELHRSP"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000084">
        <property type="entry name" value="Oxidoreductase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF128">
        <property type="entry name" value="NADPH OXIDOREDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="427"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5429541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="584" mass="64181" checksum="17761EE72A5C1B56" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM77</accession>
    <accession>E9BV77</accession>
    <name>A0A3Q8IM77_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bromodomain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DNA-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">DNA-binding_protein_putative/GeneDB:LmjF.36.6880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_18650</name>
        <name evidence="8" type="ORF">CGC21_38815</name>
        <name evidence="6" type="ORF">LDBPK_367210</name>
        <name evidence="4" type="ORF">LdCL_360084700</name>
        <name evidence="5" type="ORF">LDHU3_36.9580</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865831.1">
        <property type="nucleotide sequence ID" value="XM_003865783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM77"/>
    <dbReference type="SMR" id="A0A3Q8IM77"/>
    <dbReference type="GeneID" id="13386686"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360084700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9580"/>
    <dbReference type="OMA" id="KCATQRR"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5435309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ39156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP53379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="286" mass="33163" checksum="A7556BC43C567707" modified="2019-04-10" version="1">MSSRDQFLVDELRSRLKRRRADIVRYLDGLFYDECRRIIECVSELDRDNLFLRNPSSLPDYAQHVTRPMYWELIQRKLQRYEYRTAADFMADMRAVVNNCYLYNGIQAPASKLARTMEVLMEDRFVTELRAAPVPPAEVKKACTGMSSADSREILRIYALYEGLEVGSMMGNVNIQLRTAKSATLRRMLEYARSSAEHREKKAKLRRAAKVSRVSDRRRRAMAGVHAAVMQQDADVQFHHDTEPRLEHVPQNAQAATSMMEEVSPIRIEEEGEWFDDGDFEESSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IME4</accession>
    <name>A0A3Q8IME4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350032300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350032300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3490"/>
    <dbReference type="OrthoDB" id="272263at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018540202" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1342" mass="145083" checksum="2ABFA3C8ABE63BB0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQP5</accession>
    <accession>E9BTK1</accession>
    <name>A0A3Q8IQP5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA ATPase, CDC48 subfamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Transitional endoplasmic reticulum ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_13015</name>
        <name evidence="8" type="ORF">LDBPK_361420</name>
        <name evidence="7" type="ORF">LdCL_360019700</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865258.1">
        <property type="nucleotide sequence ID" value="XM_003865210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQP5"/>
    <dbReference type="SMR" id="A0A3Q8IQP5"/>
    <dbReference type="GeneID" id="13388143"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1800"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="6">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="5">
        <location>
            <begin position="116"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="227"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="500"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="784" mass="86819" checksum="146A7E2E98137D37" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4V4</accession>
    <name>A0A3S5H4V4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_010009800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0530"/>
    <dbReference type="OrthoDB" id="267822at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1544" mass="161640" checksum="9CC4A5DF08E865D9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Z8</accession>
    <accession>E9B7I1</accession>
    <name>A0A3S5H4Z8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 26S proteasome regulatory subunit rpn-6.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_020340</name>
        <name evidence="7" type="ORF">LdCL_020008800</name>
        <name evidence="8" type="ORF">LDHU3_02.0450</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5426997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799589">
        <property type="protein sequence ID" value="CBZ31204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857930.1">
        <property type="nucleotide sequence ID" value="XM_003857882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4Z8"/>
    <dbReference type="GeneID" id="13390064"/>
    <dbReference type="KEGG" id="ldo:LDBPK_020340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0450"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000019">
        <property type="entry name" value="Proteasome regulatory non-ATPase subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="225"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5426997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="529" mass="59003" checksum="B831834A8BAF36A8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H593</accession>
    <accession>E9B7Z4</accession>
    <name>A0A3S5H593_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase GroES-like domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase GroES-like domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_15785</name>
        <name evidence="10" type="ORF">CGC21_2585</name>
        <name evidence="9" type="ORF">LDBPK_040280</name>
        <name evidence="8" type="ORF">LdCL_040008300</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000064">
        <property type="protein sequence ID" value="TPP52391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858091.1">
        <property type="nucleotide sequence ID" value="XM_003858043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H593"/>
    <dbReference type="GeneID" id="13390702"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0350"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000040">
        <property type="entry name" value="Nuclear receptor binding factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000514">
        <property type="entry name" value="Oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF5">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP52391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="448" mass="50268" checksum="5CE17168201AF69C" modified="2019-04-10" version="1">MRSSRHLCGLPTVRTVAATGWRYHRHGAPEKVLQYERYRVPFDRTSGQVVVKMLAAPVHRHDKNLIEGHGGPIAVPKACLPHVAGVEGVGVVEEVGSNAKLALKEGDMVWINNPSVGSWATHIVTDAENLDVVPCRADVDIEYLASLSLFHTAYHLTHDFVNIQPNDVVLQTGASSSIAQICQGYLRAKGAKLFQTMQLGRTEHAHLLAFFKLRGAFAVVPYNYARTNYMRRLLSDVPPPKLLLNHTCGGYASNLVNLLGDNGVCVTYGNTSHQPMQISNMDAIARGVQLKGFFLPSWIQRHTREARMRVHQNVVESMTITQGHGIFRAQRFKMDGDSAFAFSNAWDAPLASRKAVLRIVGEYGEWRRPRSDQAGWNIGRAVWEDMLQQMWESAGTTENPQSMKYYTPFDDIHSSFYDAKQSKELGHRDVFFRRPNAPRHNAAEQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5E1</accession>
    <name>A0A3S5H5E1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_040015600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5E1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1240"/>
    <dbReference type="OrthoDB" id="273245at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="285" mass="31255" checksum="E3ABEF4AE312E168" modified="2019-04-10" version="1">MSSDAALDEKLTELLRVMVSRLPVNKTLPAAVVQKLLLAKYGDTYPEAYVASRSTFIGDIVMKLMIEKEKAATAVTANGDASEEDDDGSNASDEDDSDEGDSGEDEEEDAASDSDDEDFDSDDDDDDDDDDAEEPKKKSARVEEVDRTALKDQQEAATPSSAVSVAERCKAMAECLRKLSYHVRAPTAEESLEDYLREYLLVEFEKHGMDPDKYSKSDIKRYRIKREVELLQQDGASLSLDRRNRAGRGFSNLAFSKEAGGSGSQASPSPSAASARQTSMFLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5K4</accession>
    <accession>E9B8H2</accession>
    <name>A0A3S5H5K4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_050820</name>
        <name evidence="2" type="ORF">LdCL_050013300</name>
        <name evidence="3" type="ORF">LDHU3_05.0910</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858269.1">
        <property type="nucleotide sequence ID" value="XM_003858221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5K4"/>
    <dbReference type="GeneID" id="13391614"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0910"/>
    <dbReference type="OMA" id="EVNVWEV"/>
    <dbReference type="OrthoDB" id="272598at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="941" mass="101723" checksum="CFCA14AB72CED86C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6I6</accession>
    <accession>E9BAP2</accession>
    <name>A0A3S5H6I6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_0975</name>
        <name evidence="7" type="ORF">LDBPK_110540</name>
        <name evidence="6" type="ORF">LdCL_110010900</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859030.1">
        <property type="nucleotide sequence ID" value="XM_003858982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6I6"/>
    <dbReference type="GeneID" id="13389834"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0690"/>
    <dbReference type="OMA" id="NARTDII"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="517"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP53043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="720" mass="79114" checksum="157B81ACFED35A6E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6S8</accession>
    <name>A0A3S5H6S8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140018200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6S8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1570"/>
    <dbReference type="OrthoDB" id="273635at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="350" mass="37916" checksum="09CF10E8B8C677E0" modified="2019-04-10" version="1">MGQLRGSAHLTRHWTRRAEPHCSGVTCGSRSITSTPTASPSTSSDTDAGAASAARLARAAEIRRKELLFRWLRRLVVPAFSIYGLFLLRPTEGHFLRYVAERRHLDAPFNAWFPPIIVSSTTEPGSKVEPAKRAPTATSTSSPTGGAGAKGGAPSLAPEVIPTVFRSERDREWAAQRFNYKKGSDDEERVARKRLLFARDRVHLPDDTVVETIRSPSEQLEELRALREHPPMHLLSEQLNSIAEESHRYAATLATAAAAAAAAQLTDPKDVASPASLSSDAAATSSLDGVASPPSQGAAAVVSSPPQVEIQFEDRSLFATAAILFRDRDDRVVRAMRFIGACGMIWKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6S9</accession>
    <accession>E9BC16</accession>
    <name>A0A3S5H6S9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_141340</name>
        <name evidence="1" type="ORF">LdCL_140019300</name>
        <name evidence="2" type="ORF">LDHU3_14.1680</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859501.1">
        <property type="nucleotide sequence ID" value="XM_003859453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6S9"/>
    <dbReference type="GeneID" id="13392879"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1680"/>
    <dbReference type="OMA" id="TSYQWEC"/>
    <dbReference type="OrthoDB" id="258353at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5428673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16370" checksum="AD9674A020C41D25" modified="2019-04-10" version="1">MESAGKGFGMLYRDMTAPPASYQWECIEDLSSHYSVAYASLTEPYTLSVLASMITVTRTAFTPGVSYSLIGIACTYDGNCGDLKRGSLLTFSLREDLIIIVAGSVSSNGITNFLPVSYYVVQLASSCSSANIANVTRPFSVGASSVWMQLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6U6</accession>
    <accession>E9BCA1</accession>
    <name>A0A3S5H6U6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_1645</name>
        <name evidence="10" type="ORF">LDBPK_150600</name>
        <name evidence="9" type="ORF">LdCL_150011100</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859585.1">
        <property type="nucleotide sequence ID" value="XM_003859537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6U6"/>
    <dbReference type="GeneID" id="13392933"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0750"/>
    <dbReference type="OMA" id="YSGWAPV"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="325" mass="36526" checksum="064A4C6CF83A895C" modified="2019-04-10" version="1">MHSMRQRSCDIFASTVSALLVTAVLTATSTILRDLVLRPRPLVSDVRVSSFSPLYHVRSPTLLSPEIPDAAIYYRPDTGGDGHRTAAKQLPSNIEIVDTVDRPEDSEEDRQRKIWQRQRLPKGFKLGMRTIDRVVLYLSGSVDFSPCWDWNTKAIYVSFIARFPSKSASQNDVVLLDAVLRPVSLPAKIARLAKLRRQERRAALPGSGNERATVAAGASPAATQMLTDEERQQLAAFEQALRNVEHDHPSVYIDHIDKRLVLNDSFKYFVDAFDDTSLGGNTVEVVLRYQVMSYSGWAPVREDVLGHQVKVKMPENAVLWKAQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6X8</accession>
    <name>A0A3S5H6X8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_160013500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6X8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0990"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="73643" checksum="C3677632227533EF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7F1</accession>
    <name>A0A3S5H7F1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin, putative</fullName>
            <ecNumber evidence="10">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_250026100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="10"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7F1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250026100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2500"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000196">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="952"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="318"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="779"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1065" mass="113465" checksum="16DB9F2C677AB136" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNY0</accession>
    <name>A0A3S7WNY0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_040017500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNY0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1440"/>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12421">
        <property type="entry name" value="RRM1_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12422">
        <property type="entry name" value="RRM2_PTBP1_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000724">
        <property type="entry name" value="Putative RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000582">
        <property type="entry name" value="RNA-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="169"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="311" mass="34523" checksum="7BA48D526D4E0BA3" modified="2019-05-08" version="1">MYGQQFVPGQMYGQPNMMPYQPGVLSPPMSTGVSVMPNYAPPYQNGMPPGSVQQQQGQGPAQGQAMPQTQPRSRNNEVGNTSSVIHMRNVTPEVTQLSIQNLAQNFGDIKHIVMLRQMNQALIEMKSPKSAEQLVDFFKEPGYAEIDGRRVYIRFSTHQNLTATQHATRTLLVSMFNTQYDVSAAAHITPEIVYQIFASYGTVERIVVLPKNESSQWNHNRVQALVQFDARESAEHVKNILQGQPVTLGETITFTLDIQFSRMDEIKTTNPTTSLVVDDEGAHRPAGTMDPMAMNAAAMTTTGMYPPMGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPI5</accession>
    <name>A0A3S7WPI5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_24130</name>
        <name evidence="6" type="ORF">LdCL_060014500</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPI5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1080"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000003">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="221" mass="23432" checksum="1C536DD834910F47" modified="2019-05-08" version="1">MDYEAAVARLSSPTLFAILHAAFGGASEHEAAVSAEAVRKPFWAGFSVGFALTFAAALVAMKGFLASLFRRPLEKCRPLRSLVATGEPVKMALVVRKDLKMSNGKIAAQCAHAAVAIVEEILAFKSTTTTSPRSALNPASALWVQWYDAWNASGSSKVALQCPDEAAMMALAKHARQMNLPHYVIRDAGRTQVAPGSKTVVAVGPGPKSLVDEVTGQLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQW9</accession>
    <name>A0A3S7WQW9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_090021200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQW9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1740"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="285"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="573" mass="63911" checksum="BE04BF1AFAD8E423" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRT4</accession>
    <name>A0A3S7WRT4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_110017800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRT4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1440"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="692" mass="77045" checksum="4775D6C5BD334775" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSK9</accession>
    <accession>E9BBI4</accession>
    <name>A0A3S7WSK9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_33470</name>
        <name evidence="3" type="ORF">LDBPK_131100</name>
        <name evidence="2" type="ORF">LdCL_130016300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859321.1">
        <property type="nucleotide sequence ID" value="XM_003859273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSK9"/>
    <dbReference type="GeneID" id="13390748"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1360"/>
    <dbReference type="OMA" id="VTEPHWR"/>
    <dbReference type="OrthoDB" id="269713at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="185" mass="21543" checksum="404C5ABF6B2ACA6C" modified="2019-05-08" version="1">MLRITPSRYASKVTAGNAKNQAGSPRQKAKIFHVIPGTPVTPVEKLKEQRRRFGQDRYSRQPEYRPGRNVRMDPNTFTLYATTKGVMTIRTSRINPSYKWLDVEPDIQKVYRSRCMRAALQARGKASMMVAGNAHYRAELDHVTEPHWRERVMRVPKATERFQDPNCFTRGLVPFLRPLSRYSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT90</accession>
    <accession>E9BC55</accession>
    <name>A0A3S7WT90_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger (CCCH type) protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Zinc finger C-x8-C-x5-C-x3-H type (And similar) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Zinc_finger_(CCCH_type)_protein_putative/GeneDB:L mjF.15.0140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_29965</name>
        <name evidence="10" type="ORF">CGC21_1865</name>
        <name evidence="9" type="ORF">LDBPK_150140</name>
        <name evidence="7" type="ORF">LdCL_150006300</name>
        <name evidence="8" type="ORF">LDHU3_15.0190</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000037">
        <property type="protein sequence ID" value="TPP53097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859539.1">
        <property type="nucleotide sequence ID" value="XM_003859491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT90"/>
    <dbReference type="GeneID" id="13392901"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0190"/>
    <dbReference type="OMA" id="TGRIAQC"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000003">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="215" mass="23822" checksum="D2A9C53285D4CB51" modified="2019-05-08" version="1">MPKANKHAEVKPSKYKTSLCQFFCKGEECPYAGRCAFAHGEHELQTESKNVELLKATGLQRLDGLHAQKEVAVAESHTPSSNSVTGSATSESLAPSEPATPTSPAVRPRRRTVMVSLPKHNTRSEMYQSPYSATPYEPCYSEYGRAEYRYPTQLAQQPVYHMRSNESPHVSLCAPSNAHDNQYCDCRFSATCSQGQPSKYRHNPYGMAGRIAQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTW9</accession>
    <name>A0A3S7WTW9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_160012000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTW9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0820"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000142">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="133"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="8">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="447" mass="48539" checksum="FC551408DD6176D9" modified="2019-05-08" version="1">MASKRRRQSSGDSASSSTSSSSTSELPPSKKAAGGQRVTAEAAVAPITTVATSATATAAGGAKKKATTGSPARRTSSAPKISNGDAGRLIRSAEALATLNTKKSEKEIWSDVVPFVRRTTDSDFDPSRMYKFITWNVAGLRGLLKKNASALRAFMEAEKPDVLCLQETKLNVDEADANATLGVVDGYSFVDHPCAFKRGYSGTRTYMKNSTTVKRLHARCTRGFALPSEPQAGAAAGSPVLVEGAGDEEGRVLTTFLSPDPDSASSSSRIALVNTYVANSGMGLTRLPYRVQSFDPSMREYLQRLDTWATENAGVPSAAAKGGDSSPHGFIWAGDLNVAERDYDRYYAGTFKSMQECSGFAPEERISFRETMQRTNSVDVFRQLYPHAGPVYSFWSQRINGRPRNLGWRLDYFVVSSRLASYVVDCFPMPTVMGSDHCPFQMWMQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUP0</accession>
    <name>A0A3S7WUP0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_37385</name>
        <name evidence="8" type="ORF">LdCL_170021500</name>
        <name evidence="9" type="ORF">LDHU3_17.2060</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000040">
        <property type="protein sequence ID" value="TPP55032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUP0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.2060"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="70"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5429206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP55032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="270" mass="30250" checksum="BE7E53B5B23BBA89" modified="2019-05-08" version="1">MDEGLPIDASEAQLEAIRREVAHYPLLSLSLPLNKESMIVKEMEHDDAYLAQTLSLFGASPVSTKQYDFDSIRYSRRDGNCFYRCAGFRLCELIVEHPDRAAEYVALLKSREESLSRLFGLFVFDFTDALAEILKGVADKTITSVAQVYNRFISDDGAYVLAALRYLISAYLQEHEEEYEPFVSGLGYGTVRDYCNAEVELVDHESDNVQLAAFAKAFNVCIKVYALDRNAGNNITEYSFNGEDNDAGDRLVVGLLYMPGHYNLLGRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUV3</accession>
    <accession>E9BDP7</accession>
    <name>A0A3S7WUV3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HEAT repeats/HEAT repeat, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">HEAT_repeats/HEAT_repeat_putative/Pfam:PF13646/Pf am:PF02985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_180670</name>
        <name evidence="5" type="ORF">LdCL_180011800</name>
        <name evidence="6" type="ORF">LDHU3_18.0880</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860080.1">
        <property type="nucleotide sequence ID" value="XM_003860032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUV3"/>
    <dbReference type="SMR" id="A0A3S7WUV3"/>
    <dbReference type="GeneID" id="13393502"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0880"/>
    <dbReference type="OMA" id="KFFNLCS"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000514">
        <property type="entry name" value="HEAT repeats/HEAT repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5429283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="711" mass="77234" checksum="47906186BE42D013" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW40</accession>
    <name>A0A3S7WW40_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200020000</name>
        <name evidence="3" type="ORF">LDHU3_20.1900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW40"/>
    <dbReference type="SMR" id="A0A3S7WW40"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1900"/>
    <dbReference type="OrthoDB" id="272021at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11346" checksum="A44EE0F5C24B1C40" modified="2019-05-08" version="1">MCRWTAADRDALQRLAPSERSPMVEVLERLESQGHNKPSSPMACIRPNEPEHMPNLHHHVPSELAPACCARSRMPLQGHCEANEECVAHNRVPKEYATWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWC7</accession>
    <accession>E9BF07</accession>
    <name>A0A3S7WWC7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine Rich repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Leucine Rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_33815</name>
        <name evidence="6" type="ORF">LDBPK_210220</name>
        <name evidence="5" type="ORF">LdCL_210007000</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860539.1">
        <property type="nucleotide sequence ID" value="XM_003860491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWC7"/>
    <dbReference type="GeneID" id="13386345"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0220"/>
    <dbReference type="OMA" id="AYDPAYM"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001230">
        <property type="entry name" value="Leucine Rich repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001453">
        <property type="entry name" value="Leucine Rich repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600658" evidence="4">
        <location>
            <begin position="19"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="747" mass="81177" checksum="90AFD4C3944CA95F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX43</accession>
    <name>A0A3S7WX43_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3'a2rel-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_220014100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX43"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1120"/>
    <dbReference type="OrthoDB" id="267743at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019141178" evidence="3">
        <location>
            <begin position="42"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="615" mass="62880" checksum="92E62BEC3E750DCF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX67</accession>
    <name>A0A3S7WX67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220016600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1430"/>
    <dbReference type="OrthoDB" id="10251804at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2098"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2327"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1769"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1968"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2103"/>
            <end position="2112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2501" mass="264285" checksum="BAD6D5BF15286D7A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXD8</accession>
    <name>A0A3S7WXD8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-beta-lactamase superfamily/Beta-lactamase superfamily domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_220016900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXD8"/>
    <dbReference type="SMR" id="A0A3S7WXD8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1460"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="426" mass="46096" checksum="7F80623D9B56F351" modified="2019-05-08" version="1">MTVLRRMRLTFVGTGVSSAIPVIGHLTTDCACRDAIANPSGPNRRNNVSLLISLPFAEGESGVEWHHVLIDCGKTFRSAYMRVLAPMRVQYVDALLITHGHADAMHCVEELCGMQAEAAARYAQSSSPSSAARTLAPTVVPRTLRRVPTFLTAPTLDQIAMVSPELVTQSFHIGAAPTTEMAYHSALAATADTTAGSSSSAEALSTVMDIFYMDDKKPQRMHVPFGPLSPAASAARGVNATDAASDLPFYSFPVEHGKGYVSMAWVFGRGTAFKSRQTQQQGQQQEEGSCVVYISDVSHIPATSMAFLQDLVKIDVLVLDLLAEHGAPSASHYCADEAIPLVVALAPRRTYFVGMFCSLEHHRANEALTRELAELKMRYRDELEVVVPGSSVPAVMGADREKKLAFVNRVCSMELAYDGQELDMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXK4</accession>
    <name>A0A3S7WXK4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypanothione synthetase, putative</fullName>
            <ecNumber evidence="2">6.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230010400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXK4"/>
    <dbReference type="SMR" id="A0A3S7WXK4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0710"/>
    <dbReference type="OrthoDB" id="299748at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047479">
        <property type="term" value="F:trypanothione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF17">
        <property type="entry name" value="SYNTHETASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36149" checksum="47EEF2A33FB750DE" modified="2019-05-08" version="1">MGCTSSTEAKANEAHSSSAHLSRNRVTRPPDRMGTARRLRPAAREEVDFNPENAAGAERLRPFVVTARSSSRVGAVTLHGVCGYTQNGVPAYSNGTSNTWTSTKNFREGIFMGYQWQCVEFARRWLWVTHRLLLPERSCAYCFSSCTYAYRLKKDPSPTSQRARAAMHGTAAETGAGSPSSFKEVNAATEVKLLGPYTNRDAWEKVPAKFVKQGSLVPPVADSLIVYPMSWGSPWGHIGVITAVDLDRNCVYVADQNRYFHDWNGKSYSAVFRLDCDKGRFYIRDHESECMGWLTFPTAVEGHDVWCAGDQAPRKACKRQQEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY01</accession>
    <accession>E9BGM4</accession>
    <name>A0A3S7WY01_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine nucleotide-binding beta subunit-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein beta subunit-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Guanine_nucleotide-binding_beta_subunit-like_prot ein/GeneDB:LmjF.24.0130</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_11535</name>
        <name evidence="7" type="ORF">CGC21_15745</name>
        <name evidence="5" type="ORF">LDBPK_240120</name>
        <name evidence="3" type="ORF">LdCL_240006100</name>
        <name evidence="4" type="ORF">LDHU3_24.0140</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861102.1">
        <property type="nucleotide sequence ID" value="XM_003861054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY01"/>
    <dbReference type="SMR" id="A0A3S7WY01"/>
    <dbReference type="GeneID" id="13390552"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0140"/>
    <dbReference type="OMA" id="DSLEVMC"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001339">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP44829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="555" mass="60892" checksum="4B7EF21D18C33AEB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ25</accession>
    <name>A0A3S7WZ25_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250018500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1620"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF13">
        <property type="entry name" value="WD REPEAT PROTEIN MIO ZINC-RIBBON LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1597"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1852"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1857"/>
            <end position="1868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2306" mass="235109" checksum="D9B80BBB028B3533" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZS7</accession>
    <accession>E9BIA6</accession>
    <name>A0A3S7WZS7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC21_31825</name>
        <name evidence="13" type="ORF">LDBPK_260940</name>
        <name evidence="12" type="ORF">LdCL_260015000</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861681.1">
        <property type="nucleotide sequence ID" value="XM_003861633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZS7"/>
    <dbReference type="GeneID" id="13388927"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1200"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="262"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="328"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP41134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="563" mass="64039" checksum="0DD8DF0E9F8F32A2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X083</accession>
    <accession>E9BIQ9</accession>
    <name>A0A3S7X083_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_32515</name>
        <name evidence="3" type="ORF">LDBPK_262480</name>
        <name evidence="2" type="ORF">LdCL_260030600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861833.1">
        <property type="nucleotide sequence ID" value="XM_003861785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X083"/>
    <dbReference type="GeneID" id="13389080"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260030600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3200"/>
    <dbReference type="OMA" id="SQRRWWQ"/>
    <dbReference type="OrthoDB" id="272799at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="442" mass="48656" checksum="63229FA98484EEEE" modified="2019-05-08" version="1">MRLHRRAALLLCARARRTVVSVGSSSFCATGEAAAEFSSATTPPRRRNVGSASGAVDSHAAAVLAAGGPAAAAALQHHSHHAPLQEHPRRTVYRKGGYPAVGRLRGSRLGLASGRVQTSLTVYVLAASVGLLCVLYYFTTYTYVLTTNVSPYRNSLFFHFPCDMAILENKLTHKRHTVEVVPAAMAPQPLVHDNREEVDHAGLARPKPAVVERRLHINTVLHRVFLYLQKTESLVTVDAQAEMAPYRFMDGANSLGKASRASVGFLREDQLLPDINDYRTSTASSQRRWWQWWGRGASTAAAPLLRSASGSSGYAATAAEIPATPKAPTKILLRSSVRLRDSMNGYQKGHIGTYEQFIHHLAQENIKQRYYAHVLARSMTKNSGLRKVYAEELIRNGLLSGDGVTLTELVPDVQRFADEVFAQVREKFGDDAIVYEYTATMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0D9</accession>
    <name>A0A3S7X0D9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270007600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0D9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0360"/>
    <dbReference type="OrthoDB" id="263475at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117951" checksum="198FDE3727A7CDB9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0F5</accession>
    <accession>E9BIX7</accession>
    <name>A0A3S7X0F5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_31255</name>
        <name evidence="12" type="ORF">LDBPK_270430</name>
        <name evidence="11" type="ORF">LdCL_270009100</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="5">
        <citation type="journal article" date="2019" name="Int. J. Biol. Macromol." volume="136" first="253" last="265">
            <title>Unraveling structural insights of ribokinase from Leishmania donovani.</title>
            <authorList>
                <person name="Gatreddi S."/>
                <person name="Pillalamarri V."/>
                <person name="Vasudevan D."/>
                <person name="Addlagatta A."/>
                <person name="Qureshi I.A."/>
            </authorList>
            <dbReference type="PubMed" id="31170491"/>
            <dbReference type="DOI" id="10.1016/j.ijbiomac.2019.06.001"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH ADP AND ATP</scope>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861900.1">
        <property type="nucleotide sequence ID" value="XM_003861852.1"/>
    </dbReference>
    <dbReference type="PDB" id="5ZWY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=1-329"/>
    </dbReference>
    <dbReference type="PDB" id="6A8A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B=1-329"/>
    </dbReference>
    <dbReference type="PDB" id="6A8B">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.01 A"/>
        <property type="chains" value="A/B=1-329"/>
    </dbReference>
    <dbReference type="PDB" id="6A8C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.98 A"/>
        <property type="chains" value="A/B=1-329"/>
    </dbReference>
    <dbReference type="PDBsum" id="5ZWY"/>
    <dbReference type="PDBsum" id="6A8A"/>
    <dbReference type="PDBsum" id="6A8B"/>
    <dbReference type="PDBsum" id="6A8C"/>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0F5"/>
    <dbReference type="SMR" id="A0A3S7X0F5"/>
    <dbReference type="GeneID" id="13389161"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0510"/>
    <dbReference type="OMA" id="CFARHYV"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="BRENDA" id="2.7.1.15">
        <property type="organism ID" value="2947"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000102">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17 18 19" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 18">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 18">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP47609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5ZWY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6A8A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6A8B"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6A8C"/>
        </source>
    </evidence>
    <sequence length="329" mass="35370" checksum="561CFA98B56859B6" modified="2019-05-08" version="1">MHRARNVRSHTGEYAPDILVVGSCFLDYVGYVDHMPQVGETMHSVSFHKGFGGKGANQAVAAGRLGAKVAMVSMVGTDGDGSDYIKELERNGVDTAYMFRTGKSSTGLAMILVDTKSSNNEIVICPNATNHFTPELLRAQTNNYERILHTGLKYLICQNEIPLPTTLDTIKEAHSRGVYTVFNSAPAPKPAEVEQIKPFLPYVSLFCPNEVEATLITGVKVTDTESAFSAIKALQQLGVRDVVITLGAAGFVLSENGAEPVHVTGKHVKAVDTTGAGDCFVGSMVYFMSRGRNLLEACKRANECAAISVTRKGTQLSYPHPSELPAGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0V1</accession>
    <accession>E9BJ98</accession>
    <name>A0A3S7X0V1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_32490</name>
        <name evidence="11" type="ORF">CGC21_30585</name>
        <name evidence="9" type="ORF">LDBPK_271680</name>
        <name evidence="7" type="ORF">LdCL_270023800</name>
        <name evidence="8" type="ORF">LDHU3_27.2580</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862019.1">
        <property type="nucleotide sequence ID" value="XM_003861971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0V1"/>
    <dbReference type="GeneID" id="13386754"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2580"/>
    <dbReference type="OMA" id="ARCMEFE"/>
    <dbReference type="OrthoDB" id="5579860at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001132">
        <property type="entry name" value="Casein kinase I-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="106"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5431293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP46014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="568" mass="62351" checksum="6BBC25475B658FE5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X112</accession>
    <accession>E9BJF6</accession>
    <name>A0A3S7X112_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_32200</name>
        <name evidence="10" type="ORF">CGC21_30310</name>
        <name evidence="8" type="ORF">LDBPK_272260</name>
        <name evidence="6" type="ORF">LdCL_270030000</name>
        <name evidence="7" type="ORF">LDHU3_27.3410</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862077.1">
        <property type="nucleotide sequence ID" value="XM_003862029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X112"/>
    <dbReference type="SMR" id="A0A3S7X112"/>
    <dbReference type="GeneID" id="13386812"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270030000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3410"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="301"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP45956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="392" mass="44020" checksum="A3BB24A0C2B0AD46" modified="2019-05-08" version="1">MPPKKQEKVESKTVLLGRPGSNLKVGIVGLPNVGKSTLFNILSKKGVPAENRPFCTIDPNTADINIPDDRFDKLVRIHKPASIVPAQVHICDIAGLVRGASNGEGLGNNFLSHISSCDGIIHMVRVFEEMEITHVEGDLDPIRDLEIIFSELVMKDLQCVNGLIDKLTPIVNRGLDKSKKGDLDTLHKVKGVLEEGKQVRCCQWNGKEIDFLNTIQLLTAKPAMFLVNMSEDDYMRQRNKWLKKLKDWIDEHTGEPMIPFSAELETTFVAMSPDEVDKYCEEKKTRSQIHKIVKTAYSIINLIHYFTAGADEVKCWTIQRGTKAPQAAGKIHTDMEKGFICADVIEWADFDRLESEAACRDEGKQHQQGRNYEVQDGDIIFFKFNAAKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1V5</accession>
    <name>A0A3S7X1V5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280034000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1V5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280034000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3880"/>
    <dbReference type="OrthoDB" id="272535at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018970928" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="39836" checksum="B12E322A6A527760" modified="2019-05-08" version="1">MARRHCPLFHTLLASVVVLLVVHGGAPAAGLSGSAPCPATAEAAPEWCNKLFGGAGGIVTAGAWSESFFACVCNGAAPLIISRHQDLPEESEQQSSPALLEWDSSRALSTQLSSSIAVFSSSSSSAPAKYTCRWIGFFSPYPDGEQCLPSTGVCPTNCTVMPPFLCDSQQAGSCTVSKSGTLLYTCLTCTGRLFTINTTGPDTCHRTYTEALCDPRTECSGHGCCAMQNIDPSSSSATGGVCNCFANRTHGYYAGENCAACASGYYVDSEGVCKTRVQPVQILLASIGKTWTMVSPNVSVLFLFVIFSMVRKLNASDRPFELTGLRRANLSSVQVARRRQQSLFHSKYIPMRPAKSRSFTNPHQPRTRGPSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X245</accession>
    <name>A0A3S7X245_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_280037300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X245"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280037300"/>
    <dbReference type="OrthoDB" id="276801at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16112" checksum="D6858EF6D5D3B2EB" modified="2019-05-08" version="1">MDRLILQDGSAGTHLINRSWLTVGSATFAISVNESASLGQVRKDGKHDARESPDATLEMQSSFFLQWPVGELFDFVVPVKGRKARGEEDKYFAYQNPLYDTPALEFASLQPARIVTLNAKITAAMRLMGAELAKELREHADLSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X258</accession>
    <name>A0A3S7X258_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290010200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0770"/>
    <dbReference type="OrthoDB" id="246689at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1706"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2030"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2246"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2525"/>
            <end position="2563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2585"/>
            <end position="2606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2841"/>
            <end position="2870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2030"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2053"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2097"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2110"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2121"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2296"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2360"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2447"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2493"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2593"/>
            <end position="2603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3009" mass="314765" checksum="B8EBF1B8BD7A9561" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2L2</accession>
    <accession>E9BKZ3</accession>
    <name>A0A3S7X2L2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_291960</name>
        <name evidence="3" type="ORF">LdCL_290025500</name>
        <name evidence="4" type="ORF">LDHU3_29.2810</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862614.1">
        <property type="nucleotide sequence ID" value="XM_003862566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2L2"/>
    <dbReference type="SMR" id="A0A3S7X2L2"/>
    <dbReference type="GeneID" id="13385421"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2810"/>
    <dbReference type="OMA" id="DIRGGQQ"/>
    <dbReference type="OrthoDB" id="271035at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="332" mass="37585" checksum="66C1448554407B97" modified="2019-05-08" version="1">MMEYADAYVSGGGRLRHGAQGSTTATGASRPYLEQRTVAPVTSALGQELDRLVGGTLAAQEYRDRLEALTRSVQASDDKVLNLTRLVKLSQSIQEEKEADLRRQNDELRARLKRQEQLTAQLQRQLEGMQGAVDAQALHRVVERLEGQMSACRGKQEEQWVAVQQRIGELEERLQRASTCTAERCEERLMQLDERLQKVTQSTADATNQWAKRNFVRFKEQVDSLRADLDDVRGGQKELKSTVQSASCRAEVEYKKVLLLLQQKTKEADALTSLVEKELQHLQKVAHRHQILASKEITPAFEFDEKPYDALKFAAGEGKRRGAEAAAERRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X371</accession>
    <accession>E9BLH5</accession>
    <name>A0A3S7X371_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_35190</name>
        <name evidence="2" type="ORF">LDBPK_300820</name>
        <name evidence="1" type="ORF">LdCL_300013300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862795.1">
        <property type="nucleotide sequence ID" value="XM_003862747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X371"/>
    <dbReference type="SMR" id="A0A3S7X371"/>
    <dbReference type="GeneID" id="13385502"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1030"/>
    <dbReference type="OMA" id="MSVPEWA"/>
    <dbReference type="OrthoDB" id="241739at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP45647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="124" mass="14645" checksum="E5FF4352A04FFEE5" modified="2019-05-08" version="1">MNVPEWTKDAQSIQAARDYVRQSRVVDFYEMICRNILFHHPADLTEFCLRIVKDIMNGTEITSAADFQPKRIDDNKYMRDMAVCNFLDGWILELLRERPGSDLERMEFHKRYLEGLQSEPNTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3L3</accession>
    <name>A0A3S7X3L3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligomerisation_domain_containing_protein_putativ e/Pfam:PF02410</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Oligomerization domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300026800</name>
        <name evidence="3" type="ORF">LDHU3_30.2890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3L3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300026800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2890"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000137">
        <property type="entry name" value="Uncharacterized protein L5213T.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="202" mass="23241" checksum="39F47C7AF738F380" modified="2019-05-08" version="1">MTAHEPAEEGRLPSPSRLPYDDERFAEMLLEMEVNGVIDEAWQDAKKARMEDVKEIADILSSLKVRDLCCIDVSEKTSNFDYMMFGTCEGARHIHLAAWAVQDADKVHRISKIKRKQTDELWEVVPVGRIVVNLMVESFREEMTLERKWAVTRSMDPLAAANAPISEGRQVKAHGLWTLTLNLQDLEDFEVDYCKDILMRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X464</accession>
    <name>A0A3S7X464_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310012100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X464"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0940"/>
    <dbReference type="OrthoDB" id="263617at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="560" mass="61444" checksum="BAB3065EC333D38C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4F3</accession>
    <name>A0A3S7X4F3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_310017600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4F3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1820"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22769" checksum="40C29FD6342D6C96" modified="2019-05-08" version="1">MSSYARASPRARELKVQLTLEALPLQVGQNVFGVQCKVVSNTSGKLLRGVCISLAPVLRFEIDEAWRTTRDVLFEGNLIHTVASGIPGTISGRTQVLAVRDNPVAAMRSSGLEVHAVTRAEPGAAYVGRAFSEFEEVELIGRVLVGSAPPVGELTLAALPCGRTNKRDMHHAMRATSLEPPAMAALDAPLWCHGFRTALRRASQTRCSEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5D7</accession>
    <name>A0A3S7X5D7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320018200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5D7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1610"/>
    <dbReference type="OrthoDB" id="273855at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="566" mass="60435" checksum="193BD21BEA86B1E3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5T9</accession>
    <name>A0A3S7X5T9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nsp1-like C-terminal region containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_320030300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5T9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3100"/>
    <dbReference type="OrthoDB" id="268038at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="10">
        <location>
            <begin position="453"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="650" mass="61271" checksum="C226825A1B4813F4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X601</accession>
    <accession>E9BP54</accession>
    <name>A0A3S7X601_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_21045</name>
        <name evidence="3" type="ORF">LDBPK_323030</name>
        <name evidence="2" type="ORF">LdCL_320036300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863716.1">
        <property type="nucleotide sequence ID" value="XM_003863668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X601"/>
    <dbReference type="GeneID" id="13391241"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320036300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3810"/>
    <dbReference type="OMA" id="PYSAECA"/>
    <dbReference type="OrthoDB" id="272153at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="444" mass="45833" checksum="6A386CE9B5B84BF3" modified="2019-05-08" version="1">MPSSYVCVLHSSNGYYTDDLVGNALRCVHALQCSLRAGAPDFIPSIAVFFADPHRGVKCVYSSAVPDRNHALDRVGATYPVLSDATGSVFSPDEDGGGGWRGGDTAERTVAFAQLFRLRSPQILQQAILSAVQEHNSTVPTAGAKADASSVKGFSETSPAPSASASPSSDATSMWSSLAGALLASLCYLRAHPSSAFRAADRDEADGEAGEAPGEAAAGDSSSSDAVNSAPPPRSAGSVLVFSDAKAAAVPPYSAECALAMTAVTASKMGVTVSCFGEAVLHTDSTENRLVALASSLGGFCAGRFSLHDLGHLLDGASAAVSLIGNRPRQRRDRIASQYVVGPTMLPQTPLRKRRAMDAALAESSTADFEKATTEKADTAVSFGAQDDEHASYLGWLCPSCMAVIYRPSTEVAGATTSDSRTEDGGGSGTDQGMGPRCPYCSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6Y8</accession>
    <accession>E9BPG5</accession>
    <name>A0A3S7X6Y8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_37510</name>
        <name evidence="10" type="ORF">LDBPK_332260</name>
        <name evidence="9" type="ORF">LdCL_330029600</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864051.1">
        <property type="nucleotide sequence ID" value="XM_003864003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6Y8"/>
    <dbReference type="GeneID" id="13392447"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330029600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3260"/>
    <dbReference type="OMA" id="IFHGMEA"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000124">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="753"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="960" mass="106455" checksum="5FAE18939FD6C1FB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7D4</accession>
    <name>A0A3S7X7D4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_2470</name>
        <name evidence="15" type="ORF">LdCL_340006800</name>
        <name evidence="16" type="ORF">LDHU3_34.0260</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7D4"/>
    <dbReference type="SMR" id="A0A3S7X7D4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0260"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000017">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="153"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU82349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5433568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP50520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="325" mass="34104" checksum="3B966AFD717F1155" modified="2019-05-08" version="1">MRSSAARLFRVAVLGAAGGIGQPLSLLLKCSPLVTSLSLYDIRGGPGVAADLSHIPSPAEVTGFSSGELEKAVKGADLALVVAGIPRKPGMTRDDLFHTNASIVRDLAIAVGTHAPKAIVGIITNPVNSTVPVAAEALKKVGVYDPARLFGVTTLDVVRARTFVGEALGASPYDVDVPVVGGHSGETIVPLLSGFPSLSEEQVRQLTHRIQFGGDEVVKAKNGAGSATLSMAYAASEWSISMLKALRGDRGIIEYALVESDMQRPHSRFFGCAVELGTNGVERVLPMPKLNAYEQQLLDACLPALSAEFRKGVDFAVKPHLSQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7M3</accession>
    <name>A0A3S7X7M3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340014350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7M3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340014350"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="163" mass="16530" checksum="B62B476E4D877A61" modified="2019-05-08" version="1">MSRAPLNGTIESARVPCGDYSHHITACGGLRRPREGHGVQAEHKVSEGPGLRLANLLSVLMRHAPTPAPAACTADAAASALEQDSEGGPVGSWHAVHPGPCGAGGAARVRGMEEEGRGGGPASGMARCNGGRLVVDGADVAAVRQGCVGRGCMRTRVDPLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7M4</accession>
    <name>A0A3S7X7M4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340015600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7M4"/>
    <dbReference type="SMR" id="A0A3S7X7M4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340015600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1620"/>
    <dbReference type="OrthoDB" id="267567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23918" checksum="2E4629501B9FF70C" modified="2019-05-08" version="1">MQYVASTVFYAVIQFIAFLLVVVGTPLDVFRGNDPPFFERHFCITLWGGKINCSDTSYLFTSDEIWDDCPGRRDRFRAAQALAVISIFLYGTAFFLGVLLLFCCSIFRWVCLVLNIVGIFTLATVWAAMVVTYYKDEGESCPNLNSDFIYGSGFYLFLVAWCLDIINIAVLLLPCQERGSAASEKSELEEEHEPEAVRMQEPTQQEGEEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7R4</accession>
    <accession>E9BQU2</accession>
    <name>A0A3S7X7R4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OsmC-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">OsmC-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_26030</name>
        <name evidence="3" type="ORF">LDBPK_341410</name>
        <name evidence="2" type="ORF">LdCL_340020100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864303.1">
        <property type="nucleotide sequence ID" value="XM_003864255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7R4"/>
    <dbReference type="GeneID" id="13392712"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2180"/>
    <dbReference type="OMA" id="HIEWRQG"/>
    <dbReference type="OrthoDB" id="265231at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="359" mass="38698" checksum="442A2A77B5CE4BAA" modified="2019-05-08" version="1">MYRCTRVYCGVLAVLVGELKKVPAYVFYKAREGAKTYVDSASKAIEFLKGEDPNEDPVMRGKRRQHRELYQAVLREQASKAQEDAAQRRANLSWKEKLQLSFKEARESVAQMTSAKAGVMALLQHCTASHTAEVALEQGIDVKNVQMVFEKAAANNSVGVEEIVVGYIDAPGASHEEVMAFAEKLHKVCPVAKSMHIEWRQGSADSRRHEDGSVRRADGLHCEMEQAASGVEWAERRTGGHLGGPSSAADAALTTSVESMPAGMPGSRRAHSSMSSWAARGGGSGSLRDDEDELHFPGFERRGAAWDSTRYGSSRAKEPSTETSASSYPPPPPESTSAATTQPGACSSDPASSSPSPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8D6</accession>
    <name>A0A3S7X8D6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_340045300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340045300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5840"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1304" mass="140419" checksum="84B91CCD90C815FB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAE9</accession>
    <accession>E9BTC1</accession>
    <name>A0A3S7XAE9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="7">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="7">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_29610</name>
        <name evidence="13" type="ORF">CGC21_12635</name>
        <name evidence="11" type="ORF">LDBPK_360620</name>
        <name evidence="9" type="ORF">LdCL_360011100</name>
        <name evidence="10" type="ORF">LDHU3_36.0780</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865178.1">
        <property type="nucleotide sequence ID" value="XM_003865130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAE9"/>
    <dbReference type="SMR" id="A0A3S7XAE9"/>
    <dbReference type="GeneID" id="13388064"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0780"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000175">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002295">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="27"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5434630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ38500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP42380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP48177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="746" mass="84252" checksum="326164919F30659F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBM1</accession>
    <name>A0A3S7XBM1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360056900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360056900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6690"/>
    <dbReference type="OrthoDB" id="264899at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1401" mass="150176" checksum="4235D18C184DF5E1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBN8</accession>
    <name>A0A3S7XBN8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360055100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBN8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360055100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6460"/>
    <dbReference type="OrthoDB" id="260482at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="322" mass="36267" checksum="4EE16CF0D770C2B0" modified="2019-05-08" version="1">MSACRVTPFSAGLQFTRKDVHEPPADTAVDNKSGVSDGEPQAAGRTPVREEARCFESEEERLLWKAARLRHSIETDLVPRQELAERALRHGRRQLVKLQRLLPSAAFLTFRQKCAAWCDRLRLFEELVVRTMLREAVDGAARSGDVKAPARWRKSNQWPAITNFLELQLHLCFAVKGSAAVEASSPEQSSRENSAVYRHLAAIWAAQQERLLTCDLLHRYYTLRDILHGWGNAWHVRASCADDGDNVSSTARSRLPHEPDGSCICPFTAWESLSEVDRLTSYSKICSHHLTEDVVECLEALMFTHFADVWCHVESVTSGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9B778</accession>
    <accession>A0A3S5H4T4</accession>
    <name>E9B778_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Par3/HAL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_010140</name>
        <name evidence="1" type="ORF">LdCL_010006400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857827.1">
        <property type="nucleotide sequence ID" value="XM_003857779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B778"/>
    <dbReference type="GeneID" id="13389753"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0160"/>
    <dbReference type="OMA" id="ANDVICE"/>
    <dbReference type="OrthoDB" id="10248873at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ31101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9088" checksum="BF9F4CAF9CC2F3F3" modified="2011-04-05" version="1">MKITVHVREKIIPLQCGDGTQQVVWLGSAAMIHYDASFGKRFGPPVSIRKEGGVQCDFEARVCDVLEDGQHVFVTLESDRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>E9B888</accession>
    <accession>A0A3S7WNZ6</accession>
    <name>E9B888_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_041230</name>
        <name evidence="7" type="ORF">LdCL_040017900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858185.1">
        <property type="nucleotide sequence ID" value="XM_003858137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B888"/>
    <dbReference type="GeneID" id="13391033"/>
    <dbReference type="KEGG" id="ldo:LDBPK_041230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1500"/>
    <dbReference type="OMA" id="RNMEFAE"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="PhylomeDB" id="E9B888"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="368" mass="41288" checksum="08E2699D6A3D8D66" modified="2011-04-05" version="1">MPETSSEVAPAIKSIFQGRFFLTKLLGKGGFGEVYAAVQTSNNEMVAVKMEKNNGRNSFLFHEARVMQDIQKTPTKDGISGIATLKYFGQEGDYRMLIMSMHGASLEDFHERLGRFSLKTTVMLAGQILSRLEYIHSVGYVHRDLKTDNFLVGKGSFSNRIFMIDFGLSSKFIGSDGKHRDMFTGRYFLGTSRFASLRTHQGYSQSRRDDLEQLVYIMIYMYRGRLPWSGLNIKDLSAKERKIGQIKADLSYSHICAKCPQVFEHLLFYSRNMEFAETPQYDMCHALLQSVLDSMSPRETMDYVFDWNVPASKPARQSLSPRDEIAPANANAANQPNMLSGADGKGMFSGFGSSNPPENIFSIGGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBS9</accession>
    <accession>A0A3Q8ID33</accession>
    <name>E9BBS9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 5'-phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_140440</name>
        <name evidence="5" type="ORF">LdCL_140009600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="3"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859416.1">
        <property type="nucleotide sequence ID" value="XM_003859368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBS9"/>
    <dbReference type="GeneID" id="13391403"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0560"/>
    <dbReference type="OMA" id="CPGWCAD"/>
    <dbReference type="OrthoDB" id="272739at2759"/>
    <dbReference type="PhylomeDB" id="E9BBS9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ32704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="437" mass="47475" checksum="E36247DDFA157712" modified="2011-04-05" version="1">MCACLFVWVWVCDATIIDLSLSLCAPPPQFACGSSAHMRSLQRVPRYRDPLVRNVARMLLRGLQEQHHTPSSTRLELEVRLGSILAHTRARQLDIPIAVASPALMDETARNVYQFHAGISHPLLHGMQAALLEAGLATRKDVDLQGGRVDVHVFLSNEKRLHCLYQPLHGEAPGARADGVKTAASNPEAPPYNPLCLTQSITVLSAEKKGRLAMMDMCCPGWCADLRFALSKETAVPVELTDATKERAIASRCRARTSVPVGRFFSVQMTQSIFSRDVWWYPPPAVRSYLEMDAGASSSPAAVTGTTVFGVGTVLPTPVLFYPEKAAGRIGRSDAETTIEVEVEINLRALLREWKRVYGGAAASAYLSTSALVDTTCAGTSIAGDATLKPSIATATIDDVADMHATVLAEREDPYLLRVAEEVMAVVQLLTKVRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBY9</accession>
    <accession>A0A3S5H6S5</accession>
    <name>E9BBY9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_141070</name>
        <name evidence="2" type="ORF">LdCL_140016400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859474.1">
        <property type="nucleotide sequence ID" value="XM_003859426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBY9"/>
    <dbReference type="GeneID" id="13391434"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1340"/>
    <dbReference type="OMA" id="WCCNECT"/>
    <dbReference type="OrthoDB" id="273874at2759"/>
    <dbReference type="PhylomeDB" id="E9BBY9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110461" checksum="F15CC343013095F4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>E9BC14</accession>
    <accession>A0A3Q8IC32</accession>
    <name>E9BC14_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_141320</name>
        <name evidence="2" type="ORF">LdCL_140019100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859499.1">
        <property type="nucleotide sequence ID" value="XM_003859451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BC14"/>
    <dbReference type="GeneID" id="13392878"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1660"/>
    <dbReference type="OMA" id="HRLVYGR"/>
    <dbReference type="OrthoDB" id="273283at2759"/>
    <dbReference type="PhylomeDB" id="E9BC14"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF1">
        <property type="entry name" value="PROTEIN DEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="302" mass="31021" checksum="26EADAA3FD730D89" modified="2011-04-05" version="1">MSQEEAESRFDFNEGTGVTLGSLPCFTTVPTRGAAGKALEAALEPLHRIAYGRAGNNGKRRAALASFKGFPASMEAEVAEKIAKLTKDRLRDVIKALGINVHISLSHAEVAAGVTKFLMAPRDDGRFKVSSPAAAKSKKVSPVKRPAPAGPDDESEVKKSRPEPPALSSAAAAPAASSASAASAGPSDDAVLVEVYRRVLAMTPEDRAVLGVKALRTSLEEHFKLAAGGLRHKKGIITTAASECVRALKEAEMRAAAAAVQGVSDALSTSSPTSAEQTAAPAPSGPEVLDSTAPAPVASPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCB0</accession>
    <accession>A0A3Q8IA81</accession>
    <name>E9BCB0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_150690</name>
        <name evidence="2" type="ORF">LdCL_150012000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859594.1">
        <property type="nucleotide sequence ID" value="XM_003859546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCB0"/>
    <dbReference type="GeneID" id="13393008"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0880"/>
    <dbReference type="OMA" id="SAQCWDW"/>
    <dbReference type="OrthoDB" id="273520at2759"/>
    <dbReference type="PhylomeDB" id="E9BCB0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="476" mass="50087" checksum="EF0B8AD2065A7661" modified="2011-04-05" version="1">MTSGAGIDGGVSGMAGGGRGMGSMLNTKTAASGMDINSPNSYSMVQAQGMMGMMPYMMSGGSAGGAGGGGHGVMGSGRMGTGSPNSFLPPPGEDTDQQELMRLQQTNYRVKMLPPPLTYEVHRKIWSRNEYGDEDDNDEDDVHGPGHGGAGGNVDQEHESSGGGSIANEDPIDKEQRLEAYKQIMLRWYSHIHVLEGKPEVAKRLVRVRRACPSMEEVVYSLTHPQQPGAALETEAGGDDEPTPTAVPPTLMAAAARRGSDGMPDMEEILATWSSRCWNWWQETVKRKPRRARKQGELPIAGGNGASGTNMPTTALPLAGMANGAVMPRNPSSRNMDMGDSAVPPPPPHLTGGGGGPYTYPSSYANHDGSGTAGGMPVVPSYKSFTDLSEEGMDGPAATSGSLSHYSPHHNDGGSLAPSQAQPSHPALPHDASPMASMFTVNGPRTATLRGTSEDFLENDHLTLAFTTELLKSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCG0</accession>
    <accession>A0A3Q8IIT7</accession>
    <name>E9BCG0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ domain/DnaJ central domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_151220</name>
        <name evidence="9" type="ORF">LdCL_150017700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859644.1">
        <property type="nucleotide sequence ID" value="XM_003859596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCG0"/>
    <dbReference type="GeneID" id="13393030"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1520"/>
    <dbReference type="OMA" id="PSCHGHG"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="PhylomeDB" id="E9BCG0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="478" mass="51356" checksum="D6EAF5897C6D3A9D" modified="2011-04-05" version="1">MVKETDLYDELGISPDATEPQIRSAYRRKALQYHPDKNSGDPAAAEKFKKVAEAYEILSDAERRKQYDTFGRNGLGSAAGGSGGVPGGGFGSSFGAGIDPMDIFSSFFGFASGGGPGASRQQRPAKPSFILVELQCSLEELYCGTVKVLQVRRRRLCPSCHGHGTSSGRPSPVCPQCKGNKTVTKALNFGGLTAYQQCRCDRCEGLGKLPIQSPCARCGPVYDAHQRSPLSGTHKPDPLPRGVVVEEKMIKVSIEPGTEDSDALHYVGQGDELPGFDAVGDVLVVIEQLPHPYYRRVNSTDLLLSNCRVPLGCLFRDAFSIPIELLDGRVVRLATPLRDGNVPHFLFDSQHVFVVDNEGMPLKERKRGGAAADANHNGSEAAEGVAHRKKGKLYLCIDVVFPSSLTPAQVDIITKALGGSHERDPAATGGDAGRVVTLQSHRGPAPSWYTVDAEGNAWYQPNALPTAKKKRKATSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDA6</accession>
    <accession>A0A3S7WUG8</accession>
    <name>E9BDA6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myb-like DNA-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_170850</name>
        <name evidence="12" type="ORF">LdCL_170014500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859939.1">
        <property type="nucleotide sequence ID" value="XM_003859891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDA6"/>
    <dbReference type="GeneID" id="13393357"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1240"/>
    <dbReference type="OMA" id="FEAIDMY"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="PhylomeDB" id="E9BDA6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000544">
        <property type="entry name" value="Cell division control protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="808" mass="89167" checksum="C1DD0E677F1AD3AE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFK4</accession>
    <accession>A0A3Q8IC65</accession>
    <name>E9BFK4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5 9">60S ribosomal protein L37a</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">60S_ribosomal_protein_L37a/GeneDB:LmjF.36.1925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_212190</name>
        <name evidence="10" type="ORF">LDBPK_362020</name>
        <name evidence="5" type="ORF">LdCL_210027600</name>
        <name evidence="6" type="ORF">LdCL_360025700</name>
        <name evidence="7" type="ORF">LDHU3_21.2600</name>
        <name evidence="8" type="ORF">LDHU3_36.2630</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="14" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15" key="6">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 2-91</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="5 12" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860735.1">
        <property type="nucleotide sequence ID" value="XM_003860687.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865317.1">
        <property type="nucleotide sequence ID" value="XM_003865269.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="m=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="m=1-92"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="o=2-91"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="E9BFK4"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="E9BFK4"/>
    <dbReference type="GeneID" id="13386480"/>
    <dbReference type="GeneID" id="13388203"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212190"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2630"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="268422at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13 14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13 15">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5429953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ38640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="92" mass="10313" checksum="96FAB5DE4EEB29D4" modified="2011-04-05" version="1">MAKRTVKMGVMGRYGTRYGANPRKRAKKLEVSQHAKHFCSFCGKFAFRRKAVGIWRCDGCSKTVAGGAYTLSTPNNSTVRSTVRRLRELAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFW7</accession>
    <accession>A0A3S5H7B1</accession>
    <name>E9BFW7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_2165</name>
        <name evidence="4" type="ORF">LDBPK_221010</name>
        <name evidence="5" type="ORF">LDBPK_221020</name>
        <name evidence="3" type="ORF">LdCL_220017600</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860848.1">
        <property type="nucleotide sequence ID" value="XM_003860800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFW7"/>
    <dbReference type="GeneID" id="13389571"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221010"/>
    <dbReference type="KEGG" id="ldo:LDBPK_221020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1530"/>
    <dbReference type="OMA" id="VHRMAPH"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000019">
        <property type="entry name" value="Gamma-glutamylcyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="280" mass="31170" checksum="6085F93B82E2D05E" modified="2011-04-05" version="1">MSSSSELATRATRYHEQFGLPSFDDHVFVIFGYGSILWKQNFEFDAEYETYIKGYKRVFYQGSRDHRGVPDKPGRVVTLLPSEDKEQRVYGKAYQLPADPEKLNKIFQALDVREGGYDRVQLTLFNAHPTTGNLTTTPILPASMPKSFKTESSTQYVPPPRQNSSDVEAGDAEEVLDIFSHPNAPAVQPRKNVVCLCYIATEQNEGYVGEASMEAMAEEILSCAGVSGSNREYLFFLADCLRAMGATDPHVFELDAVAKRILRGREAEFAAGAKRVATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIR6</accession>
    <accession>A0A3S7X087</accession>
    <name>E9BIR6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_262550</name>
        <name evidence="3" type="ORF">LdCL_260031400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861839.1">
        <property type="nucleotide sequence ID" value="XM_003861791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIR6"/>
    <dbReference type="GeneID" id="13389087"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3280"/>
    <dbReference type="OMA" id="CRSLWEP"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="E9BIR6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="488" mass="52665" checksum="C07777D03E8DF0CB" modified="2011-04-05" version="1">MEAVQIAKSILAADGQPFVILSLAQGFAPVTPETPLPVARRSYMRLAGVIHPDRLKGSFDKATEAFQCLVSAFECFADPKARKQAAAAAQGKSKAESRASTAADGRKAKAAPPSSTTSRPSASQQMKKANSKAAAAPAVKKPKASAEGEEESESESDTEDDDASEASVADEKAWEALAAANTEPEVSTNRTPIGQPRLGGLYQHTTVGCPKCRSLWEPDSRPQYSLFMGQWGKKVHCQLCLFQFGCATALHGCPHCSAPFDYDASMYDTVQTCQRCKRQFGFPYYPVSQHLIDQIALEEWRERMERQKTSEREARARARHGGGGRDEATATEKMQLLVGTCIMEEECPLCHKRVKSKHRAHVEECMATPPGELATSAGRASRKTTRAAPPADKVAKAPASRTAKTTPKANPKTTTPGATKKSAVPRAPRAEASPPATAKGKKTSAPQKRKRQRSDSDFSEGEDSLSDSEEDAISSESSFSYSDYDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIW1</accession>
    <accession>A0A3Q8IE36</accession>
    <name>E9BIW1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_270270</name>
        <name evidence="2" type="ORF">LdCL_270007500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861884.1">
        <property type="nucleotide sequence ID" value="XM_003861836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIW1"/>
    <dbReference type="GeneID" id="13389145"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0350"/>
    <dbReference type="OMA" id="HNAHLSY"/>
    <dbReference type="OrthoDB" id="272507at2759"/>
    <dbReference type="PhylomeDB" id="E9BIW1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35272" checksum="F20AFA79712FD530" modified="2011-04-05" version="1">MWRLHISTSLPAAPTHDGVSILIGQRSCVSSSAHEAPCTVCVLAGYVQCDDPSVAEEQIESLENVLPFGIEVLGFAGGTAALTSLAAELPDLKRKELIEAVVPNGKRHLPPACRMFGAPAKKVEVSESDIAFVEARCALHTYNSTLPLLISCSNALPQVVDGESYAPLTARAPSSSSKIELIQSGVVPNTLRIHVVMVPSLMSASGLYETLFRQLKAAWTSRTTRLIELNSHNAHLSYCCRLECDADALDSTDTVTDDEWAVVLEMMEDATGQRVSRGDVRGIKPLFQPCRKSKTSAAEAVKTSPAQLPHFLLLGLIVVIISVAVLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKE9</accession>
    <accession>A0A3S7X235</accession>
    <name>E9BKE9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LDBPK_290020</name>
        <name evidence="14" type="ORF">LdCL_290005100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862420.1">
        <property type="nucleotide sequence ID" value="XM_003862372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKE9"/>
    <dbReference type="GeneID" id="13385423"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0030"/>
    <dbReference type="OMA" id="DWCLSAR"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="PhylomeDB" id="E9BKE9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000006">
        <property type="entry name" value="Transcription factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000004">
        <property type="entry name" value="Transcription factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000021">
        <property type="entry name" value="Transcription factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="12">
        <location>
            <begin position="535"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="13">
        <location>
            <begin position="797"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="920"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114824" checksum="6D20AC59166637C4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKL0</accession>
    <accession>A0A3S7X267</accession>
    <name>E9BKL0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette protein subfamily A, member 10, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette subfamily A, member 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_290640</name>
        <name evidence="12" type="ORF">LdCL_290011200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862481.1">
        <property type="nucleotide sequence ID" value="XM_003862433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13387220"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0920"/>
    <dbReference type="OMA" id="ARAQTCD"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="PhylomeDB" id="E9BKL0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001253">
        <property type="entry name" value="ATP-binding cassette protein subfamily A, member 10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1346"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1376"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1458"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="672"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1539"/>
            <end position="1768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1866" mass="206874" checksum="FD0970BA22134FF0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMB9</accession>
    <accession>A0A3S7X3Y7</accession>
    <name>E9BMB9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_303760</name>
        <name evidence="2" type="ORF">LdCL_300043000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863087.1">
        <property type="nucleotide sequence ID" value="XM_003863039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMB9"/>
    <dbReference type="GeneID" id="13385796"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300043000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.5000"/>
    <dbReference type="OMA" id="WYHASTV"/>
    <dbReference type="OrthoDB" id="276840at2759"/>
    <dbReference type="PhylomeDB" id="E9BMB9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="857" mass="96265" checksum="99B3A506B8FA9FDB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNX5</accession>
    <accession>A0A3Q8IJC8</accession>
    <name>E9BNX5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_322230</name>
        <name evidence="3" type="ORF">LdCL_320027700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863637.1">
        <property type="nucleotide sequence ID" value="XM_003863589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNX5"/>
    <dbReference type="GeneID" id="13390925"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2770"/>
    <dbReference type="OMA" id="RTYCVIP"/>
    <dbReference type="OrthoDB" id="244294at2759"/>
    <dbReference type="PhylomeDB" id="E9BNX5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110593" checksum="8870F4221552C7B3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>E9BRC2</accession>
    <accession>A0A3Q8IUU8</accession>
    <name>E9BRC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_343240</name>
        <name evidence="8" type="ORF">LdCL_340041300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864483.1">
        <property type="nucleotide sequence ID" value="XM_003864435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BRC2"/>
    <dbReference type="SMR" id="E9BRC2"/>
    <dbReference type="GeneID" id="13387362"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340041300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5420"/>
    <dbReference type="OMA" id="CMDYLQG"/>
    <dbReference type="OrthoDB" id="276741at2759"/>
    <dbReference type="PhylomeDB" id="E9BRC2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000049">
        <property type="entry name" value="ZFP family member, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="475" mass="53662" checksum="DCEBF25756A6EF7A" modified="2011-04-05" version="1">MFGGGEEYFQDPPEIDRDTLGRYATFCARLRAIEKPGKRTITEAATLAREVGDTLLDYELVVGALFRHIKTWTGQKQLACWYILDKLCKEDRDKYGYTAGKYILEVGRDHIPYEDADLAGKYESLVEHWENVFPRHVVDALWIAKKERLWAVDHPTEVKQQQQAEEEEWAREEEVMQDEDGLNDFGQPCIDYLQGHCSWGDSCRLYHPPGEEGSLPAECRMGDWKCSACGVINRHFRRRCSNCVREKPQYKKGRVPSAEDKLLCTPDPAVTAAFHQQFGYNPYMPAEAVAHFKLRLEGVSAEEYRKERAAAYRVRILGKAPTNPVEERCKATKHFPDIDMEPDEEYEVGTDGLVAKRQRTESLVPANASPNSAIALLAQLVMERGILDPTVPQIFGELSRYIRQAAGDPAMELNETQAEVLLSACKLGFTAWNANKGAVPSVATFFKAVRHNESKLGLSSEQAEQLESMASMFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9V0</accession>
    <name>A0A3Q8I9V0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_140016300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9V0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1330"/>
    <dbReference type="OrthoDB" id="265779at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="436" mass="46900" checksum="80B23861A16BEF40" modified="2019-04-10" version="1">MSAAAADYPLRRRGDVEDDFDEEEHRRLTESSINAFLEEEGVPVSSSVTVEDITSALVALGNSVATAAASFVVKVALLRLDCLAAVEGELRKDVACASSSKVRVTADKSPPRRSSRASAFGWLRHLYKEEKGVCGFLRGGQAEFGFVLASFVEEALLFAAMRSLMDRLGSLLPSQSSRAGGAAALWWAGLSRTVAPTFAMSLLSWPLRAVRTTIRVNYMADTSLPVCEPSPQPAQQRGEQQRRRQHRYTSATEVWGCVLHRMGARSLLLNGLDVDLASRALSLGLAWTVVKPASRWMQRWAMMSTSNAGGASAPLTLVRLGQHRLFALGVLLAVAGSVNALQRPFIVLRQRMALLPVADAESACNGGDDQTKTPPTARRGCRYANGWDCAVQVWRQEGVAGLLAGLQLCLITSSVVPLLQTLAGYPTAPSFSGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA90</accession>
    <name>A0A3Q8IA90_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myo-inositol-1 phosphatase, putative</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_150014900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA90"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1220"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000033">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="473" mass="49741" checksum="914C90BD7501444D" modified="2019-04-10" version="1">MSISVMSTPVPASSSADTGEMSLIEALGVAIEAADKGSRIIWQCVEKRRLAMAAAATFHTTSALAAGGAASVECENKTSATNLVTQHSKQCRETIIRILRQYSEEVQREKPHLRFAFLTEELNPGTPLSDDYTWVVDPIDGAASFVHGLPDCCISIGLTYRKQPVLAVVFTPFISSGVRLTVAAAAVLNVAQQQQQQQYQHQQQQLVMSPTLSVTAPAISGTMCGSVAAAPLTPMDVSKTKMLGEHGTAAAPTTALPPTPPTPPFPSLRAAAAATAAASASPHSVPIITHTTPSVVPECNGELFTAIKGFGAFVNGRQVRVNAKVVPATSVVVFNHPCGVMLSTAEAASPDGAAIRRRKCDAAIDCSMAMREELLRLPVAALRCYGSCAATLAQVAAGRVDAYLEPAGKAWDVCAGSLLVTEAGGVVCNMLGRPLDMAHDTTIVAAATQEMADLMTEKCVRHGFGQYWLVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAV7</accession>
    <name>A0A3Q8IAV7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pentamidine resistance protein 1</fullName>
            <ecNumber evidence="13">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_230007800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="13"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0440"/>
    <dbReference type="OrthoDB" id="250133at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="970"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="270"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="667"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="633"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="887"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1571" mass="174019" checksum="1FAD5DA0A39903AB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB13</accession>
    <name>A0A3Q8IB13_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_230017500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1420"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18623">
        <property type="entry name" value="GH32_ScrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="404"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="552" mass="62290" checksum="95E638133A8D33ED" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBZ2</accession>
    <accession>E9BI21</accession>
    <name>A0A3Q8IBZ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_260091</name>
        <name evidence="2" type="ORF">LdCL_260005800</name>
        <name evidence="3" type="ORF">LdCL_260006100</name>
        <name evidence="4" type="ORF">LdCL_260006400</name>
        <name evidence="5" type="ORF">LDHU3_26.0120</name>
        <name evidence="6" type="ORF">LDHU3_26.0160</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861597.1">
        <property type="nucleotide sequence ID" value="XM_003861549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBZ2"/>
    <dbReference type="GeneID" id="13388842"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260091"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260091.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0160"/>
    <dbReference type="OMA" id="IPPAVKH"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5430847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8884" checksum="DF6185514F47253E" modified="2019-04-10" version="1">MPGRHGKQRVKRKKSKRQPVTDMERTLKDSIHGRKRKERSILKNLIPPKVVPKVNKVAMSSALPMFQPRTGKKQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC08</accession>
    <name>A0A3Q8IC08_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210015400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC08"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1240"/>
    <dbReference type="OrthoDB" id="267481at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="910" mass="94375" checksum="BA312E0DD09B3E4F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC55</accession>
    <accession>E9BFI7</accession>
    <name>A0A3Q8IC55_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_34620</name>
        <name evidence="9" type="ORF">LDBPK_212010</name>
        <name evidence="8" type="ORF">LdCL_210025800</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860718.1">
        <property type="nucleotide sequence ID" value="XM_003860670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC55"/>
    <dbReference type="GeneID" id="13386545"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2400"/>
    <dbReference type="OMA" id="CAYFTLA"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14133">
        <property type="entry name" value="PKc_DYRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000216">
        <property type="entry name" value="Putative serine/threonine-protein kinase dyrk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF124">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="192"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP49416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="499" mass="55619" checksum="91BBF09FCF0C468D" modified="2019-04-10" version="1">MPTSSGVDQAKLREVIRVLKSVGHVGMAESLEVEWGMRPNTASHAKNAKKGRKSQPHKSRESSKARGNSFPSLSSIAVAPSPLQVTSQRRFVVTCIGDEEDLWSPDEDPADAKCCIAPLFDYGAGLLRDHYVEYAAHPVSLVSVHPYEKQQPPSNLPWRHFELKVFYEAGKTGSEEKKEFELVRGYLIGGRYRVDAPIDAATFSRTVRCYDEQTGQPVCLKIIRNSKTFLDQGLDELRALTCVNDAGDADACCVVRLLDYFYFREHLVLVTELLFDNLYEYARKLDIVERCAYFTLARLQRIVRQVLTALKLIHSVNLIHCDIKPENIAFKSVADCDVKVLDLGSSCYMTDTLSSYVQSRSYRAPEVILGCKYGPAVDIWSLGATAAELATGTVLFNVESVPTMLASIASVCGPIPAEMLQEGRNTSLYVTKHGAFYDYEDEQLVFHFPSEPPDAAVLFGFDDHDYVGFVRLCLTLDAALRPSAAQLLDHPFLTKTYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID24</accession>
    <accession>E9BBR2</accession>
    <name>A0A3Q8ID24_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_4545</name>
        <name evidence="10" type="ORF">LDBPK_140270</name>
        <name evidence="9" type="ORF">LdCL_140007700</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859399.1">
        <property type="nucleotide sequence ID" value="XM_003859351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID24"/>
    <dbReference type="GeneID" id="13391091"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0360"/>
    <dbReference type="OMA" id="WNPFRHV"/>
    <dbReference type="OrthoDB" id="272417at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="336"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP46210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="494" mass="53218" checksum="A97EFB22D6A7574B" modified="2019-04-10" version="1">MLSSSGAFMQDYGTSSRVGSTVTWSISGGSLFRGSSADSPVITSSTGMNDIPDDVHRTVIQQLAQSFRYAPYVKGLFLLWVPLVLILALAPSTVDASSSALPLIPVSRTAGNALFWCALLLIVPTNTLLIEYVKDLVVRHDSPSLGIAANLVAEHAAELTFSFFAMAHSKQSLCWVKPMLLGCTLLNLLGVLGSSILAAPLADGTSVDLGISSWTAFSASGVVFSTVVFLLPTVYGVTVVGPNAVDQLRRQHAPAKEVEEQRMYSMLFISRSLALCVLAVYALYLWKVMRANSNYDLSSDSPEAPSSLIYALQYHERLRGTRDVDLGSRYSQRFAVMGTLVCVTTLTTLCLVLVATLPAAKTTTSVPLPFTLVILLPCVFEAGGAAASVLLSQAGRPDIAAIIAFSSIVHLYMFILPVLVLVGWWALQAPLELSFHPFLACCCFVSTLVVAQVVASNRVRWLEGGTLLALYALIVCICLLGRWHLCMRADDSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID69</accession>
    <accession>E9BHD5</accession>
    <name>A0A3Q8ID69_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_250310</name>
        <name evidence="2" type="ORF">LdCL_250008200</name>
        <name evidence="3" type="ORF">LDHU3_25.0380</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861362.1">
        <property type="nucleotide sequence ID" value="XM_003861314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID69"/>
    <dbReference type="GeneID" id="13388608"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0380"/>
    <dbReference type="OMA" id="EMHSNVF"/>
    <dbReference type="OrthoDB" id="267700at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9355" checksum="44D425E0461FF14D" modified="2019-04-10" version="1">MSAAEAEHTEKAAAVDEDTTSTSAKTSPKEASGKAQLSLSLTPAERRGLIMVVAVALLQEMHSNVFCGAVVGAASAAIIYNQLTRLRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEE3</accession>
    <accession>E9BKT5</accession>
    <name>A0A3Q8IEE3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_291390</name>
        <name evidence="1" type="ORF">LdCL_290019000</name>
        <name evidence="2" type="ORF">LDHU3_29.1890</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862556.1">
        <property type="nucleotide sequence ID" value="XM_003862508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEE3"/>
    <dbReference type="GeneID" id="13387294"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1890"/>
    <dbReference type="OMA" id="KIRFYIK"/>
    <dbReference type="OrthoDB" id="238526at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="296" mass="34112" checksum="05D395B4C4F02ABD" modified="2019-04-10" version="1">MAGAAWASLGNEFKSVAEDKFLKPVPDQFLTPRATTDIQPAEELLSKLVEENAERYKGIDVRDPSSMAIYEGERPRWMTMGGQVRAVSEFISGHLCHHISLPEWKDLFDLEYAEMDLTYWLYVLHVHLVSRRATSIPIEKFNRRREVLEELLVTMFDGWAATSEDIMGRPPLNKIKYYIRDMYYVTAVNFEEALLHDGPGADMMLMGFLMKFCPLPRPEDVPMFTYYTLVHYVRFHTALFDRIPDEEFAKGNFNFLSPTDPLIFSKYSDIAYDEVIRGWTVEEVEEGAGEAVPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEF5</accession>
    <accession>E9BK57</accession>
    <name>A0A3Q8IEF5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity phosphatase, catalytic domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Phopshatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_21635</name>
        <name evidence="10" type="ORF">LDBPK_280170</name>
        <name evidence="9" type="ORF">LdCL_280006600</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862118.1">
        <property type="nucleotide sequence ID" value="XM_003862070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEF5"/>
    <dbReference type="GeneID" id="13386854"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0220"/>
    <dbReference type="OMA" id="FRFIDEA"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002615">
        <property type="entry name" value="Putative phopshatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF511">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="277"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="342"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP54168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="424" mass="47456" checksum="50E72F0C06713942" modified="2019-04-10" version="1">MSNCPPASGFCDFGEWKSEEDDSEDSCSSDFSSSSSAPYVVCAQSISFATGALGKAQRKLSALPLSDTEEELRAEIEQSRLSLECNLSALRLSAVPSDVPLQILRKISLSENKLVSLPDGLFLNGSFGALVELVLNTNLLTSLPLSLFYLPHLQVLSVNNNSLTSLPFENVIGAERDAAGDPFLPSVRRIGMESNQLQLLPLSLLEWCPSLEELFLAMNEAMLDEPVSYDRLQRIRRLSTKRVVLRVDNRPRFVRQIEAQCWARTLPWLQVELNKIYPDKVLDYLFLGSLRTAQTVTVYHDLDICYVLTVGRDLEAVIEPWMQQLVLPVNDFPEQSMVPVFDDAFRFIDEARSHKKGVLIHCFAGLSRSVTIAVAYLMHLKGITRDDALALVRLARPAAQPNDGFLRELGAYEEMLRSRCVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF19</accession>
    <accession>E9BN22</accession>
    <name>A0A3Q8IF19_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_2905</name>
        <name evidence="4" type="ORF">CGC21_11015</name>
        <name evidence="2" type="ORF">LDBPK_312520</name>
        <name evidence="1" type="ORF">LdCL_310033200</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863339.1">
        <property type="nucleotide sequence ID" value="XM_003863291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF19"/>
    <dbReference type="GeneID" id="13389671"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4540"/>
    <dbReference type="OMA" id="DLCDSWM"/>
    <dbReference type="OrthoDB" id="258898at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP41371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="219" mass="24427" checksum="5568A6B4F3FC2820" modified="2019-04-10" version="1">MSKAVQFSVLKQGSLEPGSWTQRVLTIDTKSDTVTISRKHHPEHVFYHSLEVAHVQMWPRYRASEISGHFNSLKAKMTLRIFGKQVPVPKMSVEAVTAADVAEMIRVPSVPSSISLDASLNIERPPVAAATLSQKQKERHPATATSANDDLCDSWMIRFTSIDSYELAVMLLRNMRNKEGKRKRLFGDHVLQDLECVKKAWDEETKGAKSTGGALRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFP8</accession>
    <name>A0A3Q8IFP8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_300026200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFP8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2830"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002600">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20953">
        <property type="entry name" value="KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20953:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="231"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="551" mass="60771" checksum="F2843A9387F6EFEE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGL1</accession>
    <name>A0A3Q8IGL1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350046500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGL1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350046500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5360"/>
    <dbReference type="OrthoDB" id="273840at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1106" mass="118934" checksum="D25026F6004798D4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH45</accession>
    <name>A0A3Q8IH45_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_340019700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH45"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2130"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08638">
        <property type="entry name" value="DNA_pol_A_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000070">
        <property type="entry name" value="DNA polymerase I, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.10:FF:000008">
        <property type="entry name" value="Mitochondrial DNA polymerase I protein A, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.10">
        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF27">
        <property type="entry name" value="DNA POLYMERASE NU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="10">
        <location>
            <begin position="685"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="934" mass="99794" checksum="FF48CD2392DD20C6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHE0</accession>
    <accession>E9BIW6</accession>
    <name>A0A3Q8IHE0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-binding protein interacting (TIP20) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_31310</name>
        <name evidence="6" type="ORF">LDBPK_270320</name>
        <name evidence="5" type="ORF">LdCL_270008000</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861889.1">
        <property type="nucleotide sequence ID" value="XM_003861841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHE0"/>
    <dbReference type="GeneID" id="13389150"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0390"/>
    <dbReference type="OMA" id="WKLRMWA"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1228" mass="134328" checksum="AC66423A3279B411" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHI9</accession>
    <name>A0A3Q8IHI9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Squalene/phytoene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_14140</name>
        <name evidence="2" type="ORF">LdCL_360044200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHI9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360044200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5010"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000037">
        <property type="entry name" value="Phytoene synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="629" mass="69373" checksum="DC960B01B18BB2A8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHT6</accession>
    <name>A0A3Q8IHT6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300015100</name>
        <name evidence="4" type="ORF">LDHU3_30.1300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHT6"/>
    <dbReference type="SMR" id="A0A3Q8IHT6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300015100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1300"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="230"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="579" mass="63008" checksum="33E33119D4F7FB11" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II78</accession>
    <accession>E9BV61</accession>
    <name>A0A3Q8II78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_18715</name>
        <name evidence="6" type="ORF">CGC21_38750</name>
        <name evidence="4" type="ORF">LDBPK_367050</name>
        <name evidence="2" type="ORF">LdCL_360083100</name>
        <name evidence="3" type="ORF">LDHU3_36.9410</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865816.1">
        <property type="nucleotide sequence ID" value="XM_003865768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II78"/>
    <dbReference type="GeneID" id="13386670"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360083100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9410"/>
    <dbReference type="OMA" id="HIDFGMV"/>
    <dbReference type="OrthoDB" id="269884at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="273" mass="32060" checksum="792303CA22C3EF71" modified="2019-04-10" version="1">MASSSPTSSLPSLAAHFPERTGGPAWRPQASADTTWTLHGLLLTDLWEEPLHTRSRTRDRLGYIDFGMVIPPIRAFLYSMLIPYACYPIALVHLYGFYRCTRTMVFPKYYKRQRYSDRVMYGVQKRVYDTRQKRILESQVDDVQEIQHALEVVGAARNQFVDDPHRKGTAYFVVEQKIMKAEAIFTGENWAWAFISDTCRYVTPMLFAYLFHPSCKRLTVDLRLWRQGRLHWRQARHPVLNFFKTYNEYNQAMRRINVTKPAPKGAQPWSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ72</accession>
    <name>A0A3Q8IJ72_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360021900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2140"/>
    <dbReference type="OrthoDB" id="243885at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1828" mass="198591" checksum="D0B5EC82C7867508" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJD6</accession>
    <accession>E9BSR4</accession>
    <name>A0A3Q8IJD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_353940</name>
        <name evidence="1" type="ORF">LdCL_350044500</name>
        <name evidence="2" type="ORF">LDHU3_35.5110</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864973.1">
        <property type="nucleotide sequence ID" value="XM_003864925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJD6"/>
    <dbReference type="GeneID" id="13387850"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350044500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5110"/>
    <dbReference type="OMA" id="ANFAEYN"/>
    <dbReference type="OrthoDB" id="269485at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="341" mass="39911" checksum="EBB0C8D1E11BF535" modified="2019-04-10" version="1">MQQKNLVRAMQKERYKMEKGFVAYTKDLIDFFRSTRTSKSEKGTQTSEPAKQENASRALEQFYESEELIKRMKWKRVTWDEEADYTSFSKRILDNDSMFKRTTAFSFLSIHVVKDPCNTDLVNIPLAEKTIATGTLTNWLLQEREPKTVDLYPVREASERRSAFHVDWTSGAVKILDTASAQEILTFLSTVAPRLQAVQLMMEAQQARQAADIEKVRVRVGATLKFNSYETSFWDDPKRKTSPDFVNPDELEQFLSGMLKSAFLYRWFLKGQEIRVIPPGRPYYLDMEKKEIQVPANFAEYNWLKAHSHFEGVEKVADSFRRFWWFWFCFGMILVGDVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJH1</accession>
    <name>A0A3Q8IJH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300027200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJH1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2930"/>
    <dbReference type="OrthoDB" id="273377at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="649" mass="71084" checksum="622D2882DF3CCC5E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJK4</accession>
    <accession>E9BSI4</accession>
    <name>A0A3Q8IJK4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DnaJ domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_7050</name>
        <name evidence="6" type="ORF">LDBPK_353140</name>
        <name evidence="5" type="ORF">LdCL_350036300</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864893.1">
        <property type="nucleotide sequence ID" value="XM_003864845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJK4"/>
    <dbReference type="SMR" id="A0A3Q8IJK4"/>
    <dbReference type="GeneID" id="13387998"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350036300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4110"/>
    <dbReference type="OMA" id="WARQEND"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="428" mass="49471" checksum="CF3B9F66B8545430" modified="2019-04-10" version="1">MLRRTLRCLTAHSDHSGPLNPHQVLGVSPGTPFEEVRHRFYELTKRYHPDVENGDPVKFREINAAYRLLRAQYRESSIGGSAADEARRTPSSRSRQREKRETPTGGAFWAERNEQVRKANEQRERERWAAEERDRRQTREHRSFLRELLVFLNGSEIAISIGTVVLVLLYSVERYHTVNRMLAEKRRRLKNMDEGLPPPMPLEVDRTLIDKYNALPEAREQQIDALRIREESSYRRATQRKFEDFREFMFVYDPEAIASRKVASTRFSHQYMREEEIPKRCPILREFNSESRTHHYGAIQKELEQAIRETPWSAPDAGYAGALVAKGLNSIAMNSPNTTKWTFIEYTDMDNGSKNARTICLAALRNLRFGQTGMCQRVAVTGKSKLQPMLVAQREKDLKEGILKKRAIVTGGELPVKDLSAPLESMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJV0</accession>
    <accession>E9BMI5</accession>
    <name>A0A3Q8IJV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-5 sterol desaturase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Fatty acid hydroxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_12000</name>
        <name evidence="8" type="ORF">LDBPK_310620</name>
        <name evidence="7" type="ORF">LdCL_310011900</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863152.1">
        <property type="nucleotide sequence ID" value="XM_003863104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJV0"/>
    <dbReference type="GeneID" id="13385873"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0920"/>
    <dbReference type="OMA" id="KMASFDM"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="122"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="274" mass="31315" checksum="B1A16BB92712BC4B" modified="2019-04-10" version="1">MEPLYAKMASFDMEALTPAQKYGIQAAFLGIIFVSFGVYSSVVIPVIAAVVKGRIPERVKPLEKLTVKDKLYVGFAKAVTAVFVYHTYQFIRNTEVSRMSPDFLDGPAVVRSVLWLPVHLPALFILYDFFYTLFHWTLHWPPIYSLIHKHHHRQMSPFRGNTDAINDNPIEYVSGEYLHLLALYLLTRLTPVGQVHALTAIIFIFLGGTLASLNHTRVDLHIPYLFNVKAHDYHHRQPRVNFGQYIMLWDWVFGTFQAEGLPSEVSAKSLKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK12</accession>
    <name>A0A3Q8IK12_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330014900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK12"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1410"/>
    <dbReference type="OrthoDB" id="271736at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="709" mass="78646" checksum="0E2281204DAA47D2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK61</accession>
    <name>A0A3Q8IK61_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360027800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK61"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360027800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2870"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="1"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="938" mass="102460" checksum="E0DF58C1F2C04C19" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKK8</accession>
    <accession>E9BQH0</accession>
    <name>A0A3Q8IKK8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_2475</name>
        <name evidence="16" type="ORF">CGC21_25420</name>
        <name evidence="15" type="ORF">LDBPK_340160</name>
        <name evidence="13" type="ORF">LdCL_340006700</name>
        <name evidence="14" type="ORF">LDHU3_34.0240</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864181.1">
        <property type="nucleotide sequence ID" value="XM_003864133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKK8"/>
    <dbReference type="SMR" id="A0A3Q8IKK8"/>
    <dbReference type="GeneID" id="13392590"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0240"/>
    <dbReference type="OMA" id="EGQYGHK"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000268">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="155"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5433567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ37499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP39930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP50521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="331" mass="35911" checksum="1808FE9E31F710CA" modified="2019-04-10" version="1">MKPSTLSRFKVTVLGASGAIGQPLALALVQNKRVSELALYDIVQPRGVAVDLSHFPRKVKVTGYPTKWIHKALDGADLVLMSAGMPRRPGMTHDDLFNTNALTVNELSAAVARYAPKSVLAIISNPLNSMVPVAAETLQRAGVYDPRKLFGIISLNMMRARKMLGDFTGQDPEMLDVPVIGGHSGQTIVPLFSHSGVELRQEQVEYLTHRVRVGGDEVVKAKEGRGSSSLSMAFAAAEWADGVLRAMDGEKTLLHCSFVESPLFADKCRFFGSTVEVGKEGIERVLPLPSLNEYEEQQLDRCLPDLEKNIRKGLVFVAENAATSTPSTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKZ6</accession>
    <name>A0A3Q8IKZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_13950</name>
        <name evidence="2" type="ORF">LdCL_360040100</name>
        <name evidence="3" type="ORF">LDHU3_36.4590</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKZ6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4590"/>
    <dbReference type="OrthoDB" id="258554at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="109" mass="11921" checksum="C4B00D45B4443BC9" modified="2019-04-10" version="1">MVKVPQQYYDTCAWVRHHYTQAGASVVRTAPSGGSKPSVYTLPMSEPNRDLVLELFPPPAEKTTVAAASSAHSAVQPRRSDAEKETLESRYNRLLLRIIDGIASSHAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL17</accession>
    <name>A0A3Q8IL17_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative</fullName>
            <ecNumber evidence="4">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_320021700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL17"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2030"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="116"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="261" mass="28862" checksum="0CBB1399B6C58382" modified="2019-04-10" version="1">MNVPSSPASHEGPAADGSSPPVFPAAPSSAHRKRSSHPHPQNSQQSRRGKTAIPAPSTEHRRASAIADGGSPSEGKKDDGRATSKKVETVKLANEHARLSEREAKMVIARGQDGFAYRRSVQAFFVNESTQFLLCQPARTSKVNFRQTVQGGSEGDESPQETAQRETWEELGLDLEKDATFLCEAHPSAAVSGEHGEEEVFRIEKNEIVSERRKEFRYKRKAWQKLGINGQELYPLLYLLKSENSRHVGTLGSKRGVRTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILP3</accession>
    <name>A0A3Q8ILP3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_350007000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0280"/>
    <dbReference type="OrthoDB" id="272117at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF2">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0290503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2042"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="369"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="744"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="928"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1389"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1607"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1674"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1927"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2047"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2102"/>
            <end position="2114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2123" mass="239782" checksum="3AEAE1ED50CF3A11" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMF5</accession>
    <name>A0A3Q8IMF5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neutral sphingomyelinase activation associated factor-like protein</fullName>
            <ecNumber evidence="3">3.1.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_230026900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMF5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2580"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="152"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="255"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="925" mass="101997" checksum="03DB9BFAF421C742" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INY8</accession>
    <accession>E9BU03</accession>
    <name>A0A3Q8INY8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_28500</name>
        <name evidence="4" type="ORF">LDBPK_362940</name>
        <name evidence="2" type="ORF">LdCL_360035800</name>
        <name evidence="3" type="ORF">LDHU3_36.4090</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865409.1">
        <property type="nucleotide sequence ID" value="XM_003865361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INY8"/>
    <dbReference type="GeneID" id="13388295"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4090"/>
    <dbReference type="OMA" id="QDMAVQQ"/>
    <dbReference type="OrthoDB" id="272851at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="875" mass="95216" checksum="BE290F2CD01047B4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IT90</accession>
    <accession>E9BNQ1</accession>
    <name>A0A3Q8IT90_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentatricopeptide repeat domain family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_20295</name>
        <name evidence="3" type="ORF">LDBPK_321480</name>
        <name evidence="2" type="ORF">LdCL_320020500</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863564.1">
        <property type="nucleotide sequence ID" value="XM_003863516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IT90"/>
    <dbReference type="GeneID" id="13390614"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1870"/>
    <dbReference type="OMA" id="YYFRFGE"/>
    <dbReference type="OrthoDB" id="278233at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599619" description="Pentatricopeptide repeat domain family protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="75805" checksum="9F42416CCB9FBC27" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVR2</accession>
    <accession>E9BTB3</accession>
    <name>A0A3Q8IVR2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carrier family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Mitochondrial_carrier_protein_putative/GeneDB:Lmj F.36.0510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_29645</name>
        <name evidence="16" type="ORF">CGC21_12600</name>
        <name evidence="14" type="ORF">LDBPK_360540</name>
        <name evidence="12" type="ORF">LdCL_360010300</name>
        <name evidence="13" type="ORF">LDHU3_36.0700</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865170.1">
        <property type="nucleotide sequence ID" value="XM_003865122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVR2"/>
    <dbReference type="GeneID" id="13388056"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0700"/>
    <dbReference type="OMA" id="SFACFET"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="250"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="351"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="549"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ38492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP48170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="755" mass="82744" checksum="FB07860D92F194E5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4T0</accession>
    <accession>E9B774</accession>
    <name>A0A3S5H4T0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 11, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycosyl_transferase_family_11_putative/Pfam:PF01 531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_010100</name>
        <name evidence="3" type="ORF">LdCL_010006000</name>
        <name evidence="4" type="ORF">LDHU3_01.0120</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812621">
        <property type="protein sequence ID" value="CAC5426884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857823.1">
        <property type="nucleotide sequence ID" value="XM_003857775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4T0"/>
    <dbReference type="GeneID" id="13389785"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0120"/>
    <dbReference type="OMA" id="WGAYLNR"/>
    <dbReference type="OrthoDB" id="3226at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="GALACTOSIDE 2-L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927:SF9">
        <property type="entry name" value="L-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5426884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="318" mass="35433" checksum="C0F92BFC216A3A43" modified="2019-04-10" version="1">MGNQLFLVANLLATAHRTGIPAYLEAAPFSSSAEGPRPTYWDTLFRDLGRHGVQMCASSPPLPVVTVPETRPVRKVQLDAQRPCAFHMIGFFQSDAFFDDHPIMSSVIPRELWDSAREHLATYYGGGSCHTVALHVRRGDYTRFTDIFEQLDVVEYYDVAVRQLLGGLLLQPPSLLRPQQSSVDSAQAPTAGTPPLLPLHLLVFCDEERFGRTVVGYFRTKYKGAVMASLVCAATEASAIWARPTASSPSVPIMPRDVLELLMMSQCNDVVMANSTFSWWGAYLNRVSLRRVIAPSRWFVKDPYPASNHLYCPGWILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4U4</accession>
    <name>A0A3S5H4U4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acidocalcisomal exopolyphosphatase, putative</fullName>
            <ecNumber evidence="6">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_010008100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4U4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0340"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.20:FF:000012">
        <property type="entry name" value="Putative acidocalcisomal exopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1640.10:FF:000015">
        <property type="entry name" value="Putative acidocalcisomal exopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="387" mass="42593" checksum="DF3264E2DBEE7138" modified="2019-04-10" version="1">MSGVINDFLRRCLKKVAGKVQPLTVVQGNEGGDMDSIVGCIYLAMLFDKQPKFGFENPVPALNFPQEDFGLRNDVANLFKELGVDASLLMSVQRGQIAHNFVDIAALNASVVLYDHNKLRENQSDFASRVVGVVDHHFDEKQYLETTSKLRLLRTVGSACTLVTELYRECGEDVVCPTLLTAPIVLDTVNFEPAQKKVTPEDIAAYEWLHAKEVADTAAAAALFEKLSKWKDDVLTLSVPEILRRDYKQFSFKARTQKGVMSTGTSSVPCACKQLEAHFSVDLIVAEAAKYVEQHQLDVLILAFAGKVGGKHTREVAFCAKTDVISFFAPFVAEAPDGVSFTMITKCQTVDGSYEYASYSLSDPSVSRKKLVPALSEFLAEGTRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4X5</accession>
    <name>A0A3S5H4X5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_010013700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4X5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010013700"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14056" checksum="4F39DE9B4A09096F" modified="2019-04-10" version="1">MSAKIPTGALVMFSMDASFNSLLSDVSQSPGAHGERLAQRGADMKLGCVGSGARRGVRRRMFGAVMGGPVRPRQRLRTGTNERSALGQTLGGPIAFESRRLHSWKKAGWLGFLRCACRRLRLGGHRFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F1</accession>
    <accession>E9B882</accession>
    <name>A0A3S5H5F1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fructose-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_041170</name>
        <name evidence="15" type="ORF">LdCL_040017300</name>
        <name evidence="16" type="ORF">LDHU3_04.1420</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812624">
        <property type="protein sequence ID" value="CAC5427249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858179.1">
        <property type="nucleotide sequence ID" value="XM_003858131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F1"/>
    <dbReference type="SMR" id="A0A3S5H5F1"/>
    <dbReference type="GeneID" id="13391027"/>
    <dbReference type="KEGG" id="ldo:LDBPK_041170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_041170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1420"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000019">
        <property type="entry name" value="Fructose-1,6-bisphosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="14">
        <location>
            <begin position="208"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU75897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5427249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="351" mass="38856" checksum="EE120B8AE5D209D3" modified="2019-04-10" version="1">MDVRRTPTPTTLTQYIIKSQPPHSRGEFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGQSANATGDHQAKLDVISNMAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLVFFDPLDGSSNIDANVSVGSIWGVWRLPKDANINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYINYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRFLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYLGSRQEVDLCMAFRDRNVKTETLAPTSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5H9</accession>
    <name>A0A3S5H5H9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_050009600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5H9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0530"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="207"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="627" mass="71633" checksum="FD22C3B533815653" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5J2</accession>
    <name>A0A3S5H5J2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sre-2/carboxylate carrier-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Sre-2/carboxylate_carrier-like_protein/GeneDB:Lmj F.05.0680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_050011900</name>
        <name evidence="11" type="ORF">LDHU3_05.0760</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5J2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0760"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU75974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5427326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37906" checksum="DDDEEC23E904870F" modified="2019-04-10" version="1">MKQLRPDATLGEVPHFPQDLQPDQSTYKGRFLRFLSMTDPRTLLTSPTRLALSEALLERVDRREEGWATVKVADYLDARQRVQCIVHPESGKPILMPFRFSAFVPMNFINLCGMLAPSQQTPARAMFWQFSNQTYNVGFNYCNGSGKDGLPLHELAISYVVATCTACGTSYQLSKVASALSASTSSAALLLQLMIPYTAVACANIANLGVIRFRDVLRGIAVQDPETGKDLNDGKPSAVAGRLAVAQVALSRVMIPVPLMLLPPVFMNVLFHPTKGVRFFVQRRAQLFLPVNVLTLVSVLCVALPMSIAVFPQKTVVPVSWLEASFQGQTNAAGHAITHVEFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5P3</accession>
    <accession>E9B8P1</accession>
    <name>A0A3S5H5P3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MYND finger domain-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">MYND finger family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">MYND_finger_domain-like_protein/GeneDB:LmjF.06.03 00</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_20205</name>
        <name evidence="14" type="ORF">CGC21_24410</name>
        <name evidence="12" type="ORF">LDBPK_060300</name>
        <name evidence="10" type="ORF">LdCL_060008100</name>
        <name evidence="11" type="ORF">LDHU3_06.0370</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000054">
        <property type="protein sequence ID" value="TPP49799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858338.1">
        <property type="nucleotide sequence ID" value="XM_003858290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5P3"/>
    <dbReference type="SMR" id="A0A3S5H5P3"/>
    <dbReference type="GeneID" id="13391722"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0370"/>
    <dbReference type="OMA" id="CTCKTAP"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF1">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5427411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ31614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP49799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP54875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="169" mass="18709" checksum="854837FF98B4C0C1" modified="2019-04-10" version="1">MVLHIYHAAVGEKEFQFSTNINKLTQETYELDVNEAIEEVSSTILEQLTDEDALCCVCKAAPATRLIHHTMLFAETFPPRVEDLPQPVCNSANCEVVAKSRYLMDMEDATTAQGMPSPNGCFHCHKGARGAATTSVPLQRCSRCKVAKYCSVECQKADWKVHKQVCTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5T0</accession>
    <name>A0A3S5H5T0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Bifunctional dihydrofolate reductase-thymidylate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LdCL_060014000</name>
        <name evidence="20" type="ORF">LDHU3_06.1030</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5T0"/>
    <dbReference type="SMR" id="A0A3S5H5T0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1030"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000011">
        <property type="entry name" value="Bifunctional dihydrofolate reductase-thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.430.10:FF:000017">
        <property type="entry name" value="Bifunctional dihydrofolate reductase-thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012262">
        <property type="entry name" value="DHFR-TS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000389">
        <property type="entry name" value="DHFR-TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DHFR" evidence="18">
        <location>
            <begin position="26"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 17">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000389-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU76119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAC5427470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="520" mass="58646" checksum="84C749619B4E94C6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6H0</accession>
    <accession>E9BAF3</accession>
    <name>A0A3S5H6H0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase-like protein</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_23370</name>
        <name evidence="3" type="ORF">LDBPK_101090</name>
        <name evidence="2" type="ORF">LdCL_100017800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858943.1">
        <property type="nucleotide sequence ID" value="XM_003858895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6H0"/>
    <dbReference type="SMR" id="A0A3S5H6H0"/>
    <dbReference type="GeneID" id="13389243"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1440"/>
    <dbReference type="OMA" id="CGGLQPY"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00436">
        <property type="entry name" value="UP_TbUP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000016">
        <property type="entry name" value="Nucleoside phosphorylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF15">
        <property type="entry name" value="PHOSPHORYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="341" mass="36878" checksum="BE2C076C2F65E48D" modified="2019-04-10" version="1">MSGSGCGFLGNVDPDLPLTPDGVTYHVACSSERLADRIILVGDPGRVKMVSTYLDTGSIVYEASHREIKVVTGAYHGVPVTVLSTGMGTDNIEIVMNEVHILKEYDTQKRRWRARVGDDTPADPLETPFDPSRVKLIRVGTCGTPNDEVQIGCLAITRYAVGMDNTCQYYDPPAVNHTADVKEVLAKVQATSLGKVQVYATKAAPAITQGLVDACTALNRKAGVSEQQPYYVGTTCSGSGFYGCQGRSVGRFRGHLTVPHLTEELGDLRFNVSEGEQRVANIEMENSALCYLSNLLGYQAGTVCVVIARRSRTNRTFATPEQLAKGLSRAITIALETLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6H1</accession>
    <name>A0A3S5H6H1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_100018600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6H1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1520"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="53313" checksum="31717369BF2D4B7D" modified="2019-04-10" version="1">MTTQDEGAEPQWTLLVCMPECQAAHASIVRELRDAGVDVVERRFVLTPDQALTIAQQYAHLRRRAAARQFSTSTAAEAEAVKTSSQPFLSEARHRLWSETLSQQQPQQGQHPQSQQQAESRAVSGQLLDSIMRLAQGHRAHQQSGPPRVPSPGKGADGACEVAPRPSLSALLSLRGKRTSSDGASSEPTLSSQHTAHTAASAAITDTTAAGTVTPALYQRSLPGALSSSSATASPKLCTPAKDSHMFITDPQVWQQVASLLQGGTVLVLLLRAVNAVERLVRLAGPQDPLEARRVVPGSWSARYGVDEARMGVYTPSNLADARVAVEAVFGGAYADETAHGKPRLSLEREAYEVARASPATEDSPATPLSFAQILPTLRAGVPAAQRISYYTGVQGPTASAATTFATIPTAAAEGIDAVAPAEQAATDADGSMMPAVAMGPDPAVCPSATPQYPQRQERLGELDDLLRGHVGCWPSTHTHARMRVRVRSSIGVQADVDERKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6M3</accession>
    <name>A0A3S5H6M3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surface antigen protein 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_120017900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6M3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1350"/>
    <dbReference type="OrthoDB" id="2015206at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065:SF69">
        <property type="entry name" value="OS07G0466500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065">
        <property type="entry name" value="OS10G0469600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018671086" evidence="6">
        <location>
            <begin position="27"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="470"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="686" mass="72624" checksum="6AB387D443BC1BFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Q4</accession>
    <name>A0A3S5H6Q4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_130021200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1910"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000020">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000017">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000015">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002034">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000007">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF8">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1915"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2542"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4082"/>
            <end position="4147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3157"/>
            <end position="3184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3365"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="4096"/>
            <end position="4111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="4119"/>
            <end position="4134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU77236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4665" mass="529155" checksum="3D0B9C52386EC53B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6X6</accession>
    <name>A0A3S5H6X6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160012900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6X6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160012900"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="134" mass="13962" checksum="77D8A2F3035F7210" modified="2019-04-10" version="1">MAAVRIRHRPTWPPAASSSSAATSSGSRNRHSAENTSNDQLSRTPPAPDRISACSPVPRRSSRSPAAPSAAFSLPDSPATTRQTDMETGSLESTNEALRPGRTRDGPVVASKSPQSTTAALRAGASEQRRPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H727</accession>
    <accession>E9BDL7</accession>
    <name>A0A3S5H727_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPI-anchor transamidase subunit 8 (GPI8), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">GPI-anchor_transamidase_subunit_8_(GPI8)_putative /GeneDB:LmjF.18.0360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_180360</name>
        <name evidence="7" type="ORF">LdCL_180008500</name>
        <name evidence="8" type="ORF">LDHU3_18.0440</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860050.1">
        <property type="nucleotide sequence ID" value="XM_003860002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H727"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="GeneID" id="13393487"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0440"/>
    <dbReference type="OMA" id="IIYVAGH"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000016">
        <property type="entry name" value="GPI-anchor transamidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600563" evidence="6">
        <location>
            <begin position="31"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5429250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="356" mass="39685" checksum="05AE47B6036CB70C" modified="2019-04-10" version="1">MTFPTRCTATTLLVVVLVLTASSCLSDAYAAVMNAAAAAASAPLEATGKGQSNNWAVIVSSSRYLFNYRHTANALTMYHLLRQHGIDDDHILLFLSDSFACDPRNVYPAEIFSQPPGERDANGHASMNLYGCSAQVDYAGSDVDVRRFLSVLQGRYDENTPPTRRLLSDDKSNIIIYVAGHGAKSFFKFQDTEFLSSSDISETLMMMHQQRRYGRIVFLADTCHAIALCEHVEAPNVLCLAASDAESESYSFQYDEQLGTHMVSFWMNEMYSLLNGTSCSNPLTRRIGNDAVSVLHQSWYNFNYHPYRVEASRNRSKPAHRDAVNDPTALREWIVADFVCGRVPAAVPVDVRYDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H774</accession>
    <name>A0A3S5H774_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_190021000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H774"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1850"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000038">
        <property type="entry name" value="Eukaryotic translation initiation factor-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31605" checksum="408AC3FD2C766BD6" modified="2019-04-10" version="1">MDPNRRAPASTVTDEQPLTLLWGTWEMWCDMPQRQQGQGTENTNWLEQVKSIGLFDSAEGFWGIFNCTILPSQLPPNGSYYLFRKHIAPMWEHEANRRGGKWVIPFTGKSLRSEGVLQPVDEAWQTLCLSAIGELFPGDEEEVCGVTVSRGRQRTLPSGHATSVLSEWKLCLWTRSADNRGSQMRIAEYIRKQLHLQSLSKETSRDGKSGENDTLMEMPRSPDRSPVAKTREASSIPSAMTYVAHRDLMEAKQEFVKGGSSVAQAFRPKYTLAIDVRGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H781</accession>
    <accession>E9BEH0</accession>
    <name>A0A3S5H781_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galactose oxidase, central domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Kelch_domain-containing_protein/GeneDB:LmjF.20.02 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_31940</name>
        <name evidence="7" type="ORF">CGC21_29680</name>
        <name evidence="5" type="ORF">LDBPK_200230</name>
        <name evidence="3" type="ORF">LdCL_200007100</name>
        <name evidence="4" type="ORF">LDHU3_20.0240</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860363.1">
        <property type="nucleotide sequence ID" value="XM_003860315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H781"/>
    <dbReference type="SMR" id="A0A3S5H781"/>
    <dbReference type="GeneID" id="13386324"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0240"/>
    <dbReference type="OMA" id="GHSAQVE"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000160">
        <property type="entry name" value="Kelch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000195">
        <property type="entry name" value="Kelch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="417" mass="46188" checksum="47CF72177AAC6D4A" modified="2019-04-10" version="1">MPLSSDARDGGREATFHFRWLCGGSASRPSIVPRMKPPPGCCHSLVGYKDRYLILFGGGSLAHFANDVYVYDMDSRRWSRKAPENSDMVPPRLAHSSAIHGDKMIVYGGQDLCSPVVYDDVLELDLVTWRWSVLQHAQASPEGPGARRLHNAHVVGGRMYVLMGTPTEPREAPLWYLDLHTNVWHHLKPTILHDGDTTADPTTMLSLCGCSSAVSGECIYLFGGYRAEDGERSPFPQREYVNSLFEYNTRLNTWRSVRLHPLAPRPAARYAASLAVHDRYVYLFGGDANQSDMSLYFSDLWRIGVQDELATWRKVNVVGALCPSARSGCAYTCARSSLFIFGGELPVGDLTIPWLYAADLFQLPLGYSGQLTLRATAARWLGAAAGQCRETFSLCSLPEEIPLTLGARCALEEYSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H797</accession>
    <name>A0A3S5H797_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_210015300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H797"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1220"/>
    <dbReference type="OrthoDB" id="238143at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="553"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="71909" checksum="966BF4C8BC12AC8E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7S2</accession>
    <name>A0A3S5H7S2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_320027300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7S2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2710"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="174"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="500"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="737" mass="78218" checksum="07487B5372C34A2A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP80</accession>
    <name>A0A3S7WP80_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaminyl cyclase, putative</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_050014600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP80"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1050"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="907" mass="102085" checksum="DA6F825DDF885C65" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQA8</accession>
    <name>A0A3S7WQA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_0215</name>
        <name evidence="2" type="ORF">LdCL_080013200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQA8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1100"/>
    <dbReference type="OrthoDB" id="264682at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP49070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="175" mass="19750" checksum="71EC317152EED398" modified="2019-05-08" version="1">MTYRIGMLLYALLQFFAFLLVLVGTPIDMFRPHGTSRFCSTPCLTLWGYKNECFNTAYDSWADDLWANCSNRRLQFRVAQALAVISIVVYGLAFILGFIMLFCCFCLRWVCLTLNILGSATLGVVWALMVVAYYKDDGNCCPMLSSRFDFGLGFILLVSAWSLDVLGIIVLLHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQJ1</accession>
    <name>A0A3S7WQJ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Autophagy protein Atg8 ubiquitin like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_090007100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQJ1"/>
    <dbReference type="SMR" id="A0A3S7WQJ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0270"/>
    <dbReference type="OrthoDB" id="260833at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000221">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="122" mass="12472" checksum="0EDF42BAF0BC336C" modified="2019-05-08" version="1">MSAYVLSTPLEARVAKCASLRAANAVPVVVEEAQARGGKAHFSALARETTVAQLVAAVRGFRGVDAKKPVALTVAGCSVSPSATLGELHDACRRADDGMLYVAYTAERCMGAAVCTPCGSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRY8</accession>
    <name>A0A3S7WRY8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UTP23 sensor motif region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_120009600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRY8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0580"/>
    <dbReference type="OrthoDB" id="246482at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="2">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="651" mass="69260" checksum="526FC25D589A30EA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSD9</accession>
    <name>A0A3S7WSD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130008400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSD9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0420"/>
    <dbReference type="OrthoDB" id="271905at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119419" checksum="1024876086AA3527" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSN9</accession>
    <accession>E9BBN0</accession>
    <name>A0A3S7WSN9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase associated with various cellular activities (AAA) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ATPase family associated with various cellular activities (AAA), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_33635</name>
        <name evidence="4" type="ORF">LDBPK_131580</name>
        <name evidence="3" type="ORF">LdCL_130019900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859367.1">
        <property type="nucleotide sequence ID" value="XM_003859319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSN9"/>
    <dbReference type="GeneID" id="13390794"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1760"/>
    <dbReference type="OMA" id="MVQLRTH"/>
    <dbReference type="OrthoDB" id="3046016at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003199">
        <property type="entry name" value="ATPase family associated with various cellular activities (AAA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052267">
        <property type="entry name" value="N-DRC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690:SF0">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="680"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="945" mass="104272" checksum="8DCF7D90B2019038" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSV2</accession>
    <name>A0A3S7WSV2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140008700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0470"/>
    <dbReference type="OrthoDB" id="267126at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211:SF0">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN TGN38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1694"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2083"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2207"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2510"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2623"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2809"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2119"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2142"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2249"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2295"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2519"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2639"/>
            <end position="2649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2659"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2842"/>
            <end position="2855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2869" mass="298022" checksum="E13EA7AFD6357ED0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT59</accession>
    <accession>E9BC10</accession>
    <name>A0A3S7WT59_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Phosphatidyl serine synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Phosphatidylserine synthase, putative</fullName>
            <ecNumber evidence="15">2.7.8.8</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Phosphatidylserine_synthase_putative/GeneDB:LmjF. 14.1200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CGC20_38310</name>
        <name evidence="18" type="ORF">CGC21_5040</name>
        <name evidence="17" type="ORF">LDBPK_141280</name>
        <name evidence="15" type="ORF">LdCL_140018700</name>
        <name evidence="16" type="ORF">LDHU3_14.1620</name>
    </gene>
    <organism evidence="15 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 21" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="15"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859495.1">
        <property type="nucleotide sequence ID" value="XM_003859447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT59"/>
    <dbReference type="GeneID" id="13392874"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1620"/>
    <dbReference type="OMA" id="QHVLPNF"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5428667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP46309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP53423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="531" mass="60357" checksum="CF5A9C43DD78BA0B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUL2</accession>
    <accession>E9BD85</accession>
    <name>A0A3S7WUL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Bis(5'-nucleosyl)-tetraphosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Bis(5'-nucleosyl)-tetraphosphatase,symmetrical-li keprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_170640</name>
        <name evidence="3" type="ORF">LdCL_170011800</name>
        <name evidence="4" type="ORF">LDHU3_17.0940</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859918.1">
        <property type="nucleotide sequence ID" value="XM_003859870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUL2"/>
    <dbReference type="GeneID" id="13393378"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170011800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0940"/>
    <dbReference type="OMA" id="KWRRRIH"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34185" checksum="079B774A58AF61B5" modified="2019-05-08" version="1">MCIPAALNPGPLGESASPSAEDGAVEDVCVFVGDLVNKGPDSYGVVRFLRDIGAIGVLGNHDAALLQLAEKLRADVPLTDKEASSSLYPLALQCPDDVFAFMVSVPHILCFHAYRLIVVHAGIDPSISLAAQSVEAVTRMRNLVKAKKYWRQPTDEATGQPAHVALSVSAAFATLERPRLGANWGVKWSELARKLQGSVAGEEASDGGRSDSSSDRSRDHSRSGASGTVDGADDSGKKKPKKADEDAPKWRRRIHRDYTDFTVVYGHDAKRRLQVYPYAYGLDSGCVYGGELTGLVWPSTLVSVPGWTDPSPPRKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUM9</accession>
    <name>A0A3S7WUM9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_37420</name>
        <name evidence="5" type="ORF">CGC21_4315</name>
        <name evidence="3" type="ORF">LdCL_170020500</name>
        <name evidence="4" type="ORF">LDHU3_17.1950</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000040">
        <property type="protein sequence ID" value="TPP55039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUM9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1950"/>
    <dbReference type="OrthoDB" id="273177at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="587" mass="62114" checksum="397718DA5180364E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVE7</accession>
    <accession>E9BE57</accession>
    <name>A0A3S7WVE7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_19280</name>
        <name evidence="3" type="ORF">LDBPK_190620</name>
        <name evidence="2" type="ORF">LdCL_190011200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860240.1">
        <property type="nucleotide sequence ID" value="XM_003860192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVE7"/>
    <dbReference type="GeneID" id="13386052"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0700"/>
    <dbReference type="OMA" id="VPKCGVA"/>
    <dbReference type="OrthoDB" id="2160189at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948">
        <property type="entry name" value="OS08G0299200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34948:SF2">
        <property type="entry name" value="TRIPHOSPHATE TUNNEL METALLOENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="81282" checksum="08D11B9FA83FF31A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXD2</accession>
    <name>A0A3S7WXD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220020500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXD2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220020500"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14444" checksum="71E6F889E503146B" modified="2019-05-08" version="1">MRKPEHGTLQSSLRPRSGRRRGSQREGKTLPAHSRSAQLNVYSRFVATDRATPCGQRGSSHPNAPRHQLQFGSSHPNERFSGGRVPILKAGPSRGSLAPISCYAAGLFGRPSDKAAPAFAASALALGSAPRMMTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXX2</accession>
    <name>A0A3S7WXX2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230025200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXX2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2380"/>
    <dbReference type="OrthoDB" id="273147at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042479">
        <property type="entry name" value="Slf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46677:SF1">
        <property type="entry name" value="SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="89798" checksum="44982F92EBDAA3A4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY45</accession>
    <accession>E9BGR0</accession>
    <name>A0A3S7WY45_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_15910</name>
        <name evidence="3" type="ORF">LDBPK_240480</name>
        <name evidence="2" type="ORF">LdCL_240009600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861138.1">
        <property type="nucleotide sequence ID" value="XM_003861090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY45"/>
    <dbReference type="GeneID" id="13390824"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0590"/>
    <dbReference type="OMA" id="SHERWTP"/>
    <dbReference type="OrthoDB" id="267578at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="421" mass="46409" checksum="CD542EEFC195B4D9" modified="2019-05-08" version="1">MGGEGRHRLSPGDTRSRGQREADLFAHRQPSSGTGEHSVWCDLILVEAGFRPLEARNVVLVITRSKVLLRVVATGFALTIHLQDIVQVRHVVPARAVELHVEVPLAASPEEHNHPGPERWCTVAKNRLYRVYPKECGRYSTSACAQLFQLITSLLPAHVQQASEESHLDDAVAWYERVDACSMLPYHLSEEVGLRELDSISYSLPHLSSSASVARLAAFHAEARQHPPTRRQARSALSLGSSCRGFRAPSDFFDDADMAMAPHLRQIYVVPSPSFWRLPKASSPSTPSHLLSHERWTPPRLRHDVSAEAASQSASSSTSTMQRQHALRRTPESPGTFFATTAPASRHQLHQSEKRNQQSARSSPAVGVGMSRREPSLTAGMPGLRPLTARAPPFLSYSSARFSWRGAQRPANLEYGPTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY58</accession>
    <accession>E9BGT1</accession>
    <name>A0A3S7WY58_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myo-inositol/proton symporter (MIT)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Myo-inositol/proton_symporter_(MIT)/GeneDB:LmjF.2 4.0680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_240690</name>
        <name evidence="11" type="ORF">LdCL_240011900</name>
        <name evidence="12" type="ORF">LDHU3_24.0820</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861159.1">
        <property type="nucleotide sequence ID" value="XM_003861111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY58"/>
    <dbReference type="SMR" id="A0A3S7WY58"/>
    <dbReference type="GeneID" id="13390845"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0820"/>
    <dbReference type="OMA" id="ETGWRWM"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000914">
        <property type="entry name" value="Myo-inositol/proton symporter (MIT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="5"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5430399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="547" mass="58719" checksum="15FE7193807F9EFA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY78</accession>
    <name>A0A3S7WY78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Emp24/gp25L/p24 family/GOLD protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Emp24/gp25L/p24 family/GOLD, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Emp24/gp25L/p24_family/GOLD_putative/Pfam:PF01105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_11850</name>
        <name evidence="7" type="ORF">CGC21_16075</name>
        <name evidence="4" type="ORF">LdCL_240013900</name>
        <name evidence="5" type="ORF">LDHU3_24.1050</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY78"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1050"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600661" evidence="2">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="227" mass="25032" checksum="E936E0E656822FA3" modified="2019-05-08" version="1">MPRPACLCVLIALVLVNILAGGCSTGAQAFRFSVVPGKVKCFTSEQPEGGRYELRYRMMRSLTPFVSVAVTSRGGRVLMEHELAKPDAKEIVSVGKDSLISICFHTSEKAAKAAVSTNVTLDIVDAEDAELTRMKKQSYSTSSPITLGAGKGSGSMQQMQYIYETFASMRMCFVSLTRADEDIRYSLMEAERLSWIPVYIFLGLGVLMILGTFVRLQMFMHKMKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYL2</accession>
    <accession>E9BH39</accession>
    <name>A0A3S7WYL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16485</name>
        <name evidence="4" type="ORF">LDBPK_241770</name>
        <name evidence="3" type="ORF">LdCL_240023300</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861267.1">
        <property type="nucleotide sequence ID" value="XM_003861219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYL2"/>
    <dbReference type="GeneID" id="13391189"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2180"/>
    <dbReference type="OMA" id="LPWWVLN"/>
    <dbReference type="OrthoDB" id="277172at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="469" mass="51500" checksum="75A9F97EE2855060" modified="2019-05-08" version="1">MPPANGSVKDDPVAFEQSGITGRDKVREHGIPYTSPGGGEVYRDGTVSGFVRSIYEYLVDEHHRPSYSSTMIRGPDLHTRPPAWLEDKNTAIDGSPLTSVERNAPGYWSTVYKKELEVAEAIQEVKRQRRYEQDNDLVGFINRARRYFGLSPQLDEAAARSQVESRHRLEDEARRLRASTAPGASNDEVAQGEEDCGASSSPHPIGTLPRNGTTELLANVPQQRRSEHGGNGVRHTGGVLTAPWLALLESIETGRPLARVANEYRPRVDYYGLDPFLDSAPSVVWFSTKCGIAIGLAHGTAKAVQAMNVDVQFLKASGVGVLSILNMSVFASVVKWGGNTAIFACAFCVGDRLMRWIKSYTLPPHDAQCRSTSNYVMGLSFSGAMVGVLPWWVLNDTGLAMRMAASGLAVGGALGLMVGLSVQQLVALNTARLDANNRQLRRYEALLARQREWAEQVRSKYTSSTYVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZT0</accession>
    <accession>E9BI93</accession>
    <name>A0A3S7WZT0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_260810</name>
        <name evidence="1" type="ORF">LdCL_260013800</name>
        <name evidence="2" type="ORF">LDHU3_26.1070</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861668.1">
        <property type="nucleotide sequence ID" value="XM_003861620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZT0"/>
    <dbReference type="SMR" id="A0A3S7WZT0"/>
    <dbReference type="GeneID" id="13388914"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1070"/>
    <dbReference type="OMA" id="DAHFVGW"/>
    <dbReference type="OrthoDB" id="277644at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="321" mass="36167" checksum="0CCE65DF4D39EF67" modified="2019-05-08" version="1">MTGVRRDAAVETAKKSLESIVEELAPPNASSEVLAKIRSYLQQHPVDTLILNTEVQITHIENPDTGVEERVRLSPMGIKDALKQAQLRNMNLVRMGARGDDLAYCRIRRERPWVWKLVQPEMDLVNGLTGTPASDAAVAAQKQEQQVHDACSGDGQPNHPRQYLGKTKELVDHVFRDAVDAHFIGWRSKKIAQDIRKGHPVKLTIRDFQNPEAAVHKLREMSNAVKKYAEEQHIFHHFTSIVANDREASLTLSPPTANKSGTISKTVKHPSEKEWTHTLKKMEDACRKAGRSGTYVKSSKLKMRNVGATTYRVDKYGRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0M0</accession>
    <accession>E9BJ37</accession>
    <name>A0A3S7X0M0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">JmjC domain, hydroxylase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">JmjC domain, hydroxylase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">JmjC_domain_hydroxylase_putative/Pfam:PF02373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_32805</name>
        <name evidence="7" type="ORF">CGC21_30890</name>
        <name evidence="5" type="ORF">LDBPK_271030</name>
        <name evidence="3" type="ORF">LdCL_270016800</name>
        <name evidence="4" type="ORF">LDHU3_27.1650</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861958.1">
        <property type="nucleotide sequence ID" value="XM_003861910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0M0"/>
    <dbReference type="GeneID" id="13389220"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1650"/>
    <dbReference type="OMA" id="PALFYHQ"/>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="176"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="486" mass="53317" checksum="3BFFC57DB19C91C1" modified="2019-05-08" version="1">MLELDGTTLTYEGFRDACLRPNRPAVIRNACRDASGGICFDLAALKRRLCPRELCRCLGSQTLAPVYPVPSTAQVTSCDSTPAARDERRHEPPTTVRDEVVEADEEGCCKTVPLEAVLHSWAASTSAAACSPSPPHVYYLKDWHLQAALESTAATETVTTSSAASSRLCEYAKSRASGTHGDGLYRVPRFLGADWMDSFCCRHVVPSNGVLSKTAPAHDTDASTQIGFGNGESDYRFCYIGPVGSWTPLHYDVFGTYSWSFNVCGDKNWYFPTVAGNAYLHDHLFPLFPTPPDIRVLTGFELEAVVQHPGDLVFVPAFFYHQVHNITGEVFPLFAGEGAAVEDDRDQDAAEPVAPAEANEHLSAALTVSLNHNWCNTFNVERMVKAFLADARQLASHLSIEDLALICDTRDSAVWRRFADRLLHNGTNWSFASMTCFLDHCLAQLDSGVDAAVGAEDERGAAADELHRLRGQVAEEYAHLLEEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X139</accession>
    <accession>E9BJG5</accession>
    <name>A0A3S7X139_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Heat shock protein DNAJ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_32150</name>
        <name evidence="12" type="ORF">CGC21_18600</name>
        <name evidence="10" type="ORF">LDBPK_272350</name>
        <name evidence="9" type="ORF">LdCL_270031900</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP45947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000015">
        <property type="protein sequence ID" value="TPP53952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862086.1">
        <property type="nucleotide sequence ID" value="XM_003862038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X139"/>
    <dbReference type="SMR" id="A0A3S7X139"/>
    <dbReference type="GeneID" id="13386821"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3580"/>
    <dbReference type="OMA" id="NALCTKC"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000033">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000074">
        <property type="entry name" value="Heat shock protein DNAJ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP53952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="396" mass="43648" checksum="BED098F2FB63F766" modified="2019-05-08" version="1">MVKETGYYNALGVSPDASEDEIKRAYRKLALKYHPDKNTEPGAQEKFKEVSVAYECLSDPEKRKRYDQFGKDAVEMQGGGVDPSDIFASFFGGGSRPRGEPKPKDIVHELPVPLEAFYCGKTIKLAITRDRLCTQCSGTGSKVAGVSATCKDCGGRGVRMMTRQLQPGFIQQIQTACPVCKGKGTNLREEDKCVSCRGQQIIKDKKVFEVMVEKGMHRGDSVTFSGEGDQIPGVKLSGDIIIILDQKPHQAFIRKGDHLFLEQTISLAEALTGFSLNITQLDGRELAISSTAGTIIDPANMYSVSREGMPVAHTGGMERGDLIIRFKVVFPKTLRQGCVPELRKMLGYPQQPPFKDGAEQYTLQESHIDLEKEARRNAYDDDGDQPRVQTAGCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X140</accession>
    <accession>E9BK58</accession>
    <name>A0A3S7X140_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_21640</name>
        <name evidence="2" type="ORF">LDBPK_280180</name>
        <name evidence="1" type="ORF">LdCL_280006700</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862119.1">
        <property type="nucleotide sequence ID" value="XM_003862071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X140"/>
    <dbReference type="GeneID" id="13386855"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0230"/>
    <dbReference type="OMA" id="HQRHDIA"/>
    <dbReference type="OrthoDB" id="277869at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP54169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="206" mass="22922" checksum="E59EA099F2E9B2A6" modified="2019-05-08" version="1">MSFYAWRAVFYGSVWTAGDFCAQLYAAHKEAAARRASGEKRKSPRPSGAQMFAMLDKERLGQNTLFGLSIGGFIGQYERFLPRIFGTLTRNPTPCLCALGLQQLAVTPLILWSYFNAMTAARGGLSDPSFMNEHSFGARQRHDIASVERHILHDVMPYPLLVSWGVYTPLFTLAYIGPPRASTFFSSCLFVPWCGLVSHTQGNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1X5</accession>
    <accession>E9BJX2</accession>
    <name>A0A3S7X1X5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_12895</name>
        <name evidence="5" type="ORF">CGC21_22690</name>
        <name evidence="3" type="ORF">LDBPK_282520</name>
        <name evidence="1" type="ORF">LdCL_280030300</name>
        <name evidence="2" type="ORF">LDHU3_28.3410</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862350.1">
        <property type="nucleotide sequence ID" value="XM_003862302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1X5"/>
    <dbReference type="SMR" id="A0A3S7X1X5"/>
    <dbReference type="GeneID" id="13387086"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280030300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3410"/>
    <dbReference type="OMA" id="NRIKSMH"/>
    <dbReference type="OrthoDB" id="268946at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="244" mass="28501" checksum="804777D080B733C6" modified="2019-05-08" version="1">MAFRGSSARLAATPGVGIAPETTPVKYVPEMLNIQNAKWWNGRGKPVYRSTYNEKSWLQKARWGAFTKGSRPVMRQRYSAAALKEALEMVPEGFETCDVPRPPQRIRAQSEGVVGRWYTNYWTLHSVRYQCQLAGVEWQFGERQRPRTNYDEPHMYTDFEETKAIRDYRSRWINVNRSLVGMSKRMKESEEEARYLHFKKVQDTFWSNRKVLVNRVKSMHNQGTLQSAKDLPIKTINIKAFLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3T4</accession>
    <accession>E9BM63</accession>
    <name>A0A3S7X3T4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_6260</name>
        <name evidence="5" type="ORF">CGC21_36290</name>
        <name evidence="3" type="ORF">LDBPK_303200</name>
        <name evidence="1" type="ORF">LdCL_300037600</name>
        <name evidence="2" type="ORF">LDHU3_30.4270</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863031.1">
        <property type="nucleotide sequence ID" value="XM_003862983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3T4"/>
    <dbReference type="GeneID" id="13385740"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4270"/>
    <dbReference type="OMA" id="RHPYHAP"/>
    <dbReference type="OrthoDB" id="274824at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="315" mass="35322" checksum="DCA7761E5E2DD4D2" modified="2019-05-08" version="1">MRGQERIWKAAPLPQAFHAALESGNWLRALQLYQRHPYHTPPADTFDLLKAIMHYTGVGIEDVKVRFNEKIRLSASLQRRKSEEVEWSLFWEALNKGDGKMISEALSGASVSGATQQIGMAEACAVLLKGAGKEWHTRLVDDLPFSTVTRCSLLHAALAEKRPDVAAEMLSHARVTRSDLSSLWPLMAKCTWEEVLRMISACPKNAVPYSQALPFILKQGCSLQTLSEHLEHARVLGDADVVAPLLAYAVEMEDWPYVERCVGHLVDIGRITPSAREAFGHLCKLHGPKRVCHRLMEHHVELSSMTIEDLESLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X485</accession>
    <accession>E9BMK5</accession>
    <name>A0A3S7X485_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">C2 domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_11900</name>
        <name evidence="4" type="ORF">LDBPK_310820</name>
        <name evidence="3" type="ORF">LdCL_310014000</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863172.1">
        <property type="nucleotide sequence ID" value="XM_003863124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X485"/>
    <dbReference type="GeneID" id="13385893"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1210"/>
    <dbReference type="OMA" id="THVAENC"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="288" mass="31114" checksum="0407B0346BA1179D" modified="2019-05-08" version="1">MGRLEIRVCGARNVANVQKVGKPDPYVKVKLGSNKKSQIKYKTHVAENCLNPVWNELFKFQVADYDSMQVVFELWNDNVIVDDLLGSYSLSLNGLTRGVVVDTWVLLEGTKGSPSELHLRVLAVDFGRDPGPGDRLTLSLEGDTMVPSTGQTYRPPKNYVPPAQGIVLQSYPPAPLGPPPPVVYSASAAPMPQVQYGYMAPPQPQGYAYGAPPPLPQQPPSQGYGYGAAPAPQNYSYGAPPPPQPMYGAPQPPQSLPYAAGPPPPQMYGPPPPQRRPVQMAYGIPPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X538</accession>
    <name>A0A3S7X538_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320007500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0340"/>
    <dbReference type="OrthoDB" id="272915at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="769"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1786" mass="194429" checksum="F76759D026687101" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5J7</accession>
    <accession>E9BNT9</accession>
    <name>A0A3S7X5J7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_20480</name>
        <name evidence="2" type="ORF">LDBPK_321860</name>
        <name evidence="1" type="ORF">LdCL_320024100</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863602.1">
        <property type="nucleotide sequence ID" value="XM_003863554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5J7"/>
    <dbReference type="GeneID" id="13390652"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2350"/>
    <dbReference type="OMA" id="ADWLKHM"/>
    <dbReference type="OrthoDB" id="261478at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="179" mass="20920" checksum="A7A992FE5EE149AE" modified="2019-05-08" version="1">MRNLVEEAEAEYEQLGRERRDVAVLKLPHRDFDFLTAQEISVIPVHVIEAQREERRRHGTVNRDTSLCDFIKSIGLEEADIEDPVNGYSVLHIKESTRAYFGEQEEEVYRLFRNNMIRYTEDADWLKHMNFLGGQTADECERQRYLDRNAQAASDGGLMVPVTTYKQAFFAKKSKKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5K2</accession>
    <accession>E9BNQ0</accession>
    <name>A0A3S7X5K2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_20290</name>
        <name evidence="4" type="ORF">LDBPK_321470</name>
        <name evidence="3" type="ORF">LdCL_320020400</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863563.1">
        <property type="nucleotide sequence ID" value="XM_003863515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5K2"/>
    <dbReference type="GeneID" id="13390613"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1860"/>
    <dbReference type="OMA" id="NYDDAHY"/>
    <dbReference type="OrthoDB" id="271512at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="410" mass="45070" checksum="AC40ED70619710A4" modified="2019-05-08" version="1">MTVEFTELDEANRKVREWKREAKQSAPVSLAGGIDLTMCLDEMQIVVPPLSPFQVLRTSDILIQLVHIPSITTTAAASAAFGALVTLLFATKRSVTSVAQQGFLRRWAHRLLRIMVTAVASVVFARFLRERYPTVQRVSQYENLSRSPDGPCFVANRILTMTSSQAGTHADGPHHFCRSLSHRNYDDAHYSGDAVVLDITTELREHHQSLDPDAPLAITVEVLEKARVKLPAAFRDGSRPVWRLLLITRHSTTTSATRTGTTEALTEPLRVFVPLDVASATHVAAAGAKGATTAMPSESPSNAYAFLYPEAVDYLHRVFPRLVLLGIDSPSVDAPQAMPPGKHSHGSLLRCGIAILENLRYTRLSPLLESPAGDHHRGWISGSMLTVFNATQNYDDARGCSVIFFPEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5K4</accession>
    <accession>E9BNU2</accession>
    <name>A0A3S7X5K4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_20495</name>
        <name evidence="3" type="ORF">LDBPK_321890</name>
        <name evidence="2" type="ORF">LdCL_320024400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863605.1">
        <property type="nucleotide sequence ID" value="XM_003863557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5K4"/>
    <dbReference type="GeneID" id="13390655"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2380"/>
    <dbReference type="OMA" id="WDDAYLL"/>
    <dbReference type="OrthoDB" id="242742at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="153" mass="16724" checksum="BD4C3D2A7D05BE4D" modified="2019-05-08" version="1">MSSARRSRGRNGKLATCETYSRADEALWDDAYLLKLFNEQLDNASAVKDAREETQDDDESVLSTETERSDGETGRVAASATSSSTAASEGEVRVQRGSMSAKSEMISRSFPSLNGLPEDIQALVQSFYNAGFEAGRFVGRSNASKKCGRKRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5S8</accession>
    <name>A0A3S7X5S8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_20860</name>
        <name evidence="2" type="ORF">LdCL_320032200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5S8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3310"/>
    <dbReference type="OrthoDB" id="273488at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="268" mass="28534" checksum="0D279183679389BF" modified="2019-05-08" version="1">MAYTINSSRHSNGDGDGDGIAGQTQPSAASSAGAPIVRFSLLYQLRHNACSITARNSSSLQRAQSRPSLPQTGEQCGHCSAYANDFSHGETETAAGPGYMTPPQRRSRPSSTELFSGPSSSPVALSPPPATYADIPLLSTMDKRELSKVVVRDAVFGRLLDLVPSRQHIQTAVWTLSRHVIQIDGAVTVCAMPRDASNTYPLASSSHFAASNIGGGVYGDVESLRDVVRERVGELVMDARLFACLLQPYLGEIGCQGDVIQTSVEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X685</accession>
    <name>A0A3S7X685_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320043400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X685"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320043400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4740"/>
    <dbReference type="OrthoDB" id="273424at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF30">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1227" mass="131223" checksum="156974C39CC7DFBD" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X821</accession>
    <name>A0A3S7X821_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAj-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_340029700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X821"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340029700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3660"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000167">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000673">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000786">
        <property type="entry name" value="TPR-repeat-containing chaperone protein DNAJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF2">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="700"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="808" mass="88668" checksum="D80CEA901C4C1F0D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X989</accession>
    <accession>E9BS93</accession>
    <name>A0A3S7X989_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L12, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal protein L11, N-terminal domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L11, N-terminal domain/Ribosomal protein L11, RNA binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal_protein_L11_N-inal_domain/Ribosomal_pro tein_L11_RNA_binding_domain_containing_protein_putative/Pfa m:PF03946/Pfam:PF00298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_15580</name>
        <name evidence="10" type="ORF">CGC21_6625</name>
        <name evidence="9" type="ORF">LDBPK_352230</name>
        <name evidence="7" type="ORF">LdCL_350027200</name>
        <name evidence="8" type="ORF">LDHU3_35.2840</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP48102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864802.1">
        <property type="nucleotide sequence ID" value="XM_003864754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X989"/>
    <dbReference type="SMR" id="A0A3S7X989"/>
    <dbReference type="GeneID" id="13387680"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2840"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="262543at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000009">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5434244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ38122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP44492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP48102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="164" mass="17524" checksum="89389A75CE196856" modified="2019-05-08" version="1">MPPKFDPNQEIVVVVRAVGGEVAATASLAPKVGPLGLNAKKIGEDIAKCTKDWKGLKVTCELRVKNRVATVVVTPSVASRLIRALKEPPRDRKKVKNIKHSGNIPFAEIIKIAKESQPKSMGSDLKAVVMEVLGTAVSIGCTVDGESPLDIQAKVREGKLKVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9W6</accession>
    <name>A0A3S7X9W6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxisomal biogenesis factor 11 (PEX11), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_350042400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9W6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350042400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4900"/>
    <dbReference type="OrthoDB" id="275311at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42266">
        <property type="entry name" value="GIM5B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42266:SF1">
        <property type="entry name" value="GIM5B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="253" mass="27428" checksum="94525B7300FA873A" modified="2019-05-08" version="1">MPNVSLTQRVTAFNDYVGNASNRDRVMSVVQFGAMTLVAPAAAAGCPELSAHFDTILHGAAHYRTVTRFSQWLVVAPALTPSGIKSVIASHPNPLVGICKTISTAFFTVFLIGEELVLASKCNMLDPVFGRHFNRIRFVFLFWSNIARLVMNYLLLKSSKYDAVKDSQNEEKAKDHRRKVLNVADGVLQSMFCYTLLKSSAPAGPKYLSAALRSGKAVDIITSLAPPLFVVSSTPQGMLGLAASVPGFMMSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAS1</accession>
    <name>A0A3S7XAS1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase subunit Nat1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360019000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAS1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360019000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1740"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000004">
        <property type="entry name" value="N-acetyltransferase subunit Nat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000009">
        <property type="entry name" value="N-acetyltransferase subunit Nat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="711" mass="81373" checksum="ACB495A818026DE3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBY0</accession>
    <accession>E9BUV9</accession>
    <name>A0A3S7XBY0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Mechanosensitive ion channel, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Mechanosensitive_ion_channel_putative/Pfam:PF0092 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_19280</name>
        <name evidence="7" type="ORF">CGC21_15270</name>
        <name evidence="6" type="ORF">LDBPK_366020</name>
        <name evidence="4" type="ORF">LdCL_360067600</name>
        <name evidence="5" type="ORF">LDHU3_36.7940</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865714.1">
        <property type="nucleotide sequence ID" value="XM_003865666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBY0"/>
    <dbReference type="SMR" id="A0A3S7XBY0"/>
    <dbReference type="GeneID" id="13388601"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360067600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7940"/>
    <dbReference type="OMA" id="WESSESK"/>
    <dbReference type="OrthoDB" id="10036188at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049142">
        <property type="entry name" value="MS_channel_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF1">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21088">
        <property type="entry name" value="MS_channel_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mechanosensitive ion channel transmembrane helices 2/3" evidence="3">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5435181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP48704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP49579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="171" mass="17818" checksum="B0DE245601CFE60B" modified="2019-05-08" version="1">MKRFFSSLYEGTGIIKDPGQRSIASRVTALAVEGVAVFTVLGTLGVDTSPLIAAAGVTGATIGFACKDFGANFVASIALSGQRALRTGNKVSIGVGPNIVSGTVVDWDTRYIYLRNEERAVVCVPNNVVLNSVVMWKDPDTSSPLTAEGAAQANDTKDWNAAASAAEPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC89</accession>
    <name>A0A3S7XC89_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl CoA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360081200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC89"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360081200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9160"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="324" mass="35137" checksum="175BE910F891B61E" modified="2019-05-08" version="1">MELSFPDKYYEVAKYFDYYIGNLEESPLLSDAQRLMFYALRQQADHGQCTTAAPSFWYSRERHKHQAWKQLGRMSNFEAMVFFVQQFEQLLTQLENSTGQPAPTSGAAARAGGVDWPSRLREMKSKTAPNPGNSPHSSEALASGGARANNDILAIRQGPSPATAGEEACRESPPSKLSAAEMADWDADVLSHSGATVENIRYLATELMRARHAFRQLLEKNAPSHAEQNGTGASTNGPPIRAGRTCLTPSGAAPAAPGPPLKPIWCSNDSAARVPIVPPPVRPSARSMTEAAVRDSCGAPQSKKMPVATDRPVSPSALSTWFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8G5</accession>
    <accession>A0A3S5H5J8</accession>
    <name>E9B8G5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LDBPK_050750</name>
        <name evidence="19" type="ORF">LdCL_050012600</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19 22" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 22">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858262.1">
        <property type="nucleotide sequence ID" value="XM_003858214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8G5"/>
    <dbReference type="GeneID" id="13391314"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050012600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0840"/>
    <dbReference type="OMA" id="EDYWERC"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="PhylomeDB" id="E9B8G5"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000076">
        <property type="entry name" value="Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730265" description="tRNA 4-demethylwyosine synthase (AdoMet-dependent)" evidence="16">
        <location>
            <begin position="29"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="97"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="462"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBZ31538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="823" mass="90860" checksum="31B1810EFC898F1C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8I2</accession>
    <accession>A0A3S5H5K8</accession>
    <name>E9B8I2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Paraflagellar rod protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_050920</name>
        <name evidence="3" type="ORF">LdCL_050014300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858279.1">
        <property type="nucleotide sequence ID" value="XM_003858231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8I2"/>
    <dbReference type="GeneID" id="13391616"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1010"/>
    <dbReference type="OMA" id="GDMQRSE"/>
    <dbReference type="OrthoDB" id="265539at2759"/>
    <dbReference type="PhylomeDB" id="E9B8I2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007824">
        <property type="entry name" value="Flagellar_rod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053120">
        <property type="entry name" value="PFR_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732">
        <property type="entry name" value="69 KDA PARAFLAGELLAR ROD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34732:SF3">
        <property type="entry name" value="ROD PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05149">
        <property type="entry name" value="Flagellar_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117643" checksum="BBDE3C90F344740A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDQ3</accession>
    <accession>A0A3S7WUW6</accession>
    <name>E9BDQ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain Tctex-type, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Dynein-light chain-protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_180730</name>
        <name evidence="2" type="ORF">LdCL_180012400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860086.1">
        <property type="nucleotide sequence ID" value="XM_003860038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDQ3"/>
    <dbReference type="SMR" id="E9BDQ3"/>
    <dbReference type="GeneID" id="13393420"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0980"/>
    <dbReference type="OMA" id="LVCDSIM"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="PhylomeDB" id="E9BDQ3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000004">
        <property type="entry name" value="Putative dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF17">
        <property type="entry name" value="LIGHT CHAIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="250" mass="25908" checksum="0421DA74C4F38107" modified="2011-04-05" version="1">MADHSSENSTAAETVNSDLDATRPGADAATLRGSSGADETSKNVTTSGQDVPEDQQGSTTAGVADGANGEAAVSAEKATAANTNNDGSGSQEDGEADEDEEEDDAGHWERVAASDVKNIILQVLSPYFDDDVGGGAAAGPGGDLAAIPSASGPSPPAIEEDRDGDDTAQRYDHFKAEEWVALVCDGIMERLVALGKPFKFVVHAMVMRKCGAGVHVCSSCYYAPMDGWLSHAHDLSAHLYAVVTVYWCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDW4</accession>
    <accession>A0A3S5H743</accession>
    <name>E9BDW4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_181330</name>
        <name evidence="4" type="ORF">LdCL_180018600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860147.1">
        <property type="nucleotide sequence ID" value="XM_003860099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDW4"/>
    <dbReference type="GeneID" id="13385978"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1700"/>
    <dbReference type="OMA" id="MCYQGER"/>
    <dbReference type="OrthoDB" id="273228at2759"/>
    <dbReference type="PhylomeDB" id="E9BDW4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562:SF5">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37562">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="626" mass="65608" checksum="5D8D3D3091C5B99C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFN8</accession>
    <accession>A0A3S7WX31</accession>
    <name>E9BFN8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carnitine palmitoyltransferase-like protein</fullName>
            <ecNumber evidence="8">2.3.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_220190</name>
        <name evidence="8" type="ORF">LdCL_220008000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="8"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860769.1">
        <property type="nucleotide sequence ID" value="XM_003860721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFN8"/>
    <dbReference type="GeneID" id="13389334"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0460"/>
    <dbReference type="OMA" id="NRWWDKS"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="PhylomeDB" id="E9BFN8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="676" mass="74637" checksum="E12A04E94C2986B1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJQ3</accession>
    <accession>A0A3Q8IB15</accession>
    <name>E9BJQ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_281820</name>
        <name evidence="2" type="ORF">LdCL_280023200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862281.1">
        <property type="nucleotide sequence ID" value="XM_003862233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJQ3"/>
    <dbReference type="GeneID" id="13387017"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2410"/>
    <dbReference type="OMA" id="GYPRACT"/>
    <dbReference type="OrthoDB" id="272814at2759"/>
    <dbReference type="PhylomeDB" id="E9BJQ3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="464" mass="50460" checksum="885DF55CC512E5B3" modified="2011-04-05" version="1">MLPSQPRPRFTGLPPGTAFVKTALAVPPATMPRQHSTTAEMSLLHSLSASKAAASPKPPPPLPSVPANSWYAQPFVERPGTPMSTFHRNHRGKIIFSPRPVPVEEAELLALPGQEPRTLTICEVGKDLLYGMAYLYAVPLAIEHQWRGRVAYLQQVRRHQAPIPDIVLRSVQGRTALQRQHQAQEGLKASVPLSSSSPTSPAPAASALAPVEYSNIMRFERGEAAVYDRPADDFLIGIKVFVSEELVEDHYPDVHALPQCTATITAKEAAQLWSCVPFVLIGYLNQALLDPISLFHTLSLSFVEHLLRVKLPGRGPAGPAEERAKATSTRPSSSAAAPSQPTKAALLELPLRVEVVYGCRAEAFYCTDFISRGRCVLRMTEASKPSLKSYEEKLRALVKARHRAPQLIPRPASGLPPPRACAGCGYPLQFRCSFCGAEVCGSSVCALSAVIGYPRACTRHVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BL10</accession>
    <accession>A0A3S7X2T2</accession>
    <name>E9BL10_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat domain family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_292130</name>
        <name evidence="2" type="ORF">LdCL_290027300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862631.1">
        <property type="nucleotide sequence ID" value="XM_003862583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BL10"/>
    <dbReference type="GeneID" id="13385334"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290027300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3040"/>
    <dbReference type="OMA" id="VMNACRR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="PhylomeDB" id="E9BL10"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77089" checksum="116A98826B2B8CBD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMS9</accession>
    <accession>A0A3S7X4H0</accession>
    <name>E9BMS9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_311550</name>
        <name evidence="2" type="ORF">LdCL_310022600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863246.1">
        <property type="nucleotide sequence ID" value="XM_003863198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMS9"/>
    <dbReference type="GeneID" id="13389420"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310022600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2730"/>
    <dbReference type="OMA" id="CFKTNIP"/>
    <dbReference type="OrthoDB" id="242859at2759"/>
    <dbReference type="PhylomeDB" id="E9BMS9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="942" mass="100164" checksum="89B2114A3FE1A293" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNM0</accession>
    <accession>A0A3Q8IKX9</accession>
    <name>E9BNM0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_321170</name>
        <name evidence="11" type="ORF">LdCL_320017400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863533.1">
        <property type="nucleotide sequence ID" value="XM_003863485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNM0"/>
    <dbReference type="GeneID" id="13390583"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1520"/>
    <dbReference type="OMA" id="TLFRGCP"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="PhylomeDB" id="E9BNM0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000226">
        <property type="entry name" value="Mitochondrial carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000242">
        <property type="entry name" value="Putative mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="223"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="320" mass="36248" checksum="297C53B23A6A3D8C" modified="2011-04-05" version="1">MNKLSDDAEYAGWVPMSLNAIGRHAPVTIHTVSSQLASATSTCVFYPFDTLKTRFMAQDGTAVRQHNGRVYSSIQGSLALIYREEGLRTLFRGCPVAVAGSVVAWGVYMYLYRHLCNVTEYTSYVGRSGVSVLSSAISSCVTCPIFLVKSRMQLEEANRSSHYRSFWRGVRHTVHTTGVRSLWRGLSPQLFLIFPNALSIPTYDTLKRFVLRYRWDHAEMTELSLVEIAVCSTLTKVWILILSHPLVMMKVRMQDERATLGKYQYRSVAQSISNVLKTQGLQGMYRGFQTALAHSLPRSLLHYCIYEKTLSLLCRRYPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPT9</accession>
    <accession>A0A3S7X6D4</accession>
    <name>E9BPT9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZIP Zinc transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_330100</name>
        <name evidence="2" type="ORF">LdCL_330005900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863834.1">
        <property type="nucleotide sequence ID" value="XM_003863786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPT9"/>
    <dbReference type="GeneID" id="13391599"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0110"/>
    <dbReference type="OMA" id="FCDGLVI"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="PhylomeDB" id="E9BPT9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF209">
        <property type="entry name" value="ZIP ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="330" mass="34544" checksum="F004F6D36383FCB2" modified="2011-04-05" version="1">MSSVGVWLPIFLVRRGRDERSTALLEAVARGRRPHTTASFATTKLWLSLANFVSAGMLLTIALLHFFPESLEVESGASPDSVALCSWMLFGVLIPAVLERSIKVRGGHSHGATLDMDEEHAHGSGTGNSVSTSKLLIILMCFHGMTEGLLLGFENSVAALLSATVPLSGHKFCDGLVIGVSVAKEMHSEVEEDAMSDEANVEACIKANRSSNRFWRQLIQGPVGVWLLLTPMTVICVAMCAALLNGATPAVTSAGFDAAAPAALPVPSTAATTSSVSILAAVQAIGSGSFVYIGLTILCSEELKGMAANAALLAGVGLTSALFYITRGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR81</accession>
    <accession>A0A3Q8IIC9</accession>
    <name>E9BR81_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_342830</name>
        <name evidence="2" type="ORF">LdCL_340036400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864442.1">
        <property type="nucleotide sequence ID" value="XM_003864394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR81"/>
    <dbReference type="GeneID" id="13392851"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4840"/>
    <dbReference type="OMA" id="YCANPSH"/>
    <dbReference type="OrthoDB" id="273542at2759"/>
    <dbReference type="PhylomeDB" id="E9BR81"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="628" mass="67029" checksum="D4EBC6022D14C02D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BU28</accession>
    <accession>A0A3Q8IHF1</accession>
    <name>E9BU28_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA branch site protein p14, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_363190</name>
        <name evidence="4" type="ORF">LdCL_360038500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865434.1">
        <property type="nucleotide sequence ID" value="XM_003865386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BU28"/>
    <dbReference type="SMR" id="E9BU28"/>
    <dbReference type="GeneID" id="13388320"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360038500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4400"/>
    <dbReference type="OMA" id="CTGEYLY"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="PhylomeDB" id="E9BU28"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001023">
        <property type="entry name" value="Pre-mRNA branch site protein p14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730297" evidence="2">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20342" checksum="2EA58FC9D79763D7" modified="2011-04-05" version="1">MRLARFRPLVCQRAHTRRSCMLCLFLCLTILLNQPPPPLLAFLYSASVACSQASSRNASVRAAAMPDERILLVTGIPSKQCTSEYLYSLFGAYGGIQQIRIGSSSITKGCAIVVYEQCEAANNAVGALNEYALSKDRVLRVSVYEEERDKKALERRKRKREMQAEYKKHIADVAHAADEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9Z9</accession>
    <accession>E9BC39</accession>
    <name>A0A3Q8I9Z9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_5195</name>
        <name evidence="3" type="ORF">LDBPK_141570</name>
        <name evidence="2" type="ORF">LdCL_140021600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859523.1">
        <property type="nucleotide sequence ID" value="XM_003859475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9Z9"/>
    <dbReference type="SMR" id="A0A3Q8I9Z9"/>
    <dbReference type="GeneID" id="13392890"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1950"/>
    <dbReference type="OMA" id="YSQRIAF"/>
    <dbReference type="OrthoDB" id="270128at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22990">
        <property type="entry name" value="mt-LAF21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="484" mass="56300" checksum="9FC46B3FA8C98CFE" modified="2019-04-10" version="1">MLTKGYSVLLRPYQHVAFAKRSSAGGVNLNKGALTERERGDSFTEPEVYRSKTNLTAMLKTRRKERGLLKEEKQRTMMDHLNLDTRTAEALHAGRRLPQTPAEIQAVRSSDDALAEDSYDSEGYSTTMRNLMRREVDRRDHVADKFGQPPTSREFYQLFRKLRSADSDEEAVEQHQRRLVEEHGVYPSSRIDSFMLDDDSYFPDWVHALPYSIRDRVKYGSLGLTEDDEALRVRLARLPRDARLREWKRLKAAKEYAAANEETLTLAELRDARQGKRRFHWLQRKRQKRAAALRRMAMRKPDGYELWPSSVRDFSQRIAFIAQHVENGLQTGGEWPLNEDALTKAKIKRRQSEAERTFLMSPDEKKMATSAGGSRMHGGMKELLDSLDEPEKRYKKLSRKAYANRVNAIVHGDQDEHGRKYRKLHNLATRRQRRYDSLAEMALEKEVRKEPLVNVSGLNHTDDEHWSRHEKSWVDGMPSTRYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAR1</accession>
    <accession>E9BFV8</accession>
    <name>A0A3Q8IAR1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">CRAL/TRIO domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_2220</name>
        <name evidence="4" type="ORF">LDBPK_220910</name>
        <name evidence="3" type="ORF">LdCL_220016500</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000024">
        <property type="protein sequence ID" value="TPP46974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860839.1">
        <property type="nucleotide sequence ID" value="XM_003860791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAR1"/>
    <dbReference type="GeneID" id="13389562"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1420"/>
    <dbReference type="OMA" id="KADLPRY"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP46974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="715" mass="76519" checksum="55E7161FFB9BD589" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAX1</accession>
    <name>A0A3Q8IAX1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">RNA recognition motif family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_3440</name>
        <name evidence="6" type="ORF">LdCL_180006600</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAX1"/>
    <dbReference type="SMR" id="A0A3Q8IAX1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0180"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000707">
        <property type="entry name" value="RNA binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001179">
        <property type="entry name" value="RNA_recognition_motif._(A.k.a._RRM_-_RBD_-_or_RNP_domain)/RNA_recognition_motif_(A.k.a._RRM_-_RBD_-_or_RNP_domain)_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP53311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="347" mass="38453" checksum="297CDABB4484A041" modified="2019-04-10" version="1">MQNSPIIAMRSSRCPTQMQFYTPSSTNLFVRYLPREVDDNRLREIFSAFGKITSSMVMRDIYSGQSLGTAFVRYEEHEEALRAMRDAHGMPLLGKTVSVQWAKQQHDDTPAGQERLKMNKLFLRNVPLEVAEEDLVRLVSPYGSVRKVTMHNDTAPLIDATERRRIVFITFAEQGAAEAALLAVHNTCAFHQCRGIPLMGKLINDAVKSKRHRMNASRSHSIPTEFATNSPTNASARSSRIPVAPLNAADMMNATRKMSLESFSPSQVLQFISSSEESVTNTPSRSCGGLQWDVAAVMPSRASPAAVPRPIGCDSSDSSLPRSSSDVSYSSRFCHNPYSLLGEKTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB26</accession>
    <accession>E9BDN1</accession>
    <name>A0A3Q8IB26_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_3285</name>
        <name evidence="3" type="ORF">LDBPK_180500</name>
        <name evidence="2" type="ORF">LdCL_180009900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860064.1">
        <property type="nucleotide sequence ID" value="XM_003860016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB26"/>
    <dbReference type="GeneID" id="13393493"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0620"/>
    <dbReference type="OMA" id="LIMVWSN"/>
    <dbReference type="OrthoDB" id="272846at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="420" mass="44288" checksum="19B99DCFA3D3A3B5" modified="2019-04-10" version="1">MPPLTLEQVLARSMRLPRQRTQQQASRLYKRHESAELGGSPGWAPSTATGSSPVDSGAPRSSRIAALMGGRHAGKHGGAGCSGVSETVANKAKLNFFELMEREDAQRRASRLSIHSSGHLVRNSADLTTYLTTAQRTGDWEGGLRAFAEATALPAVAAMLPASEATATSAASTAGTSTTSTSLPPAPSRSGINPNEVQITAVLDMCANAEKWDLVEKIGVFFAPAYPDTFSRAVELLARRMPSDSSAGEGGWRSAFAYLTTRCPLPAAEITVEAFNVCLRGCEAALDWRGAMEVVRAMGPNPLQGWRAADEEEDEAGCAEAAASLGCPVTASDPTEADTVSSSPPTASASPARSMSTPPSPNVVSYATLIATLEQAGKESLASAVLNRLPAVEKEEITASYAALIMVWSNQILHKQRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB51</accession>
    <name>A0A3Q8IB51_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_220010300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB51"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0710"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000151">
        <property type="entry name" value="Rab-GTPase-TBC_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="755"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1134" mass="120536" checksum="641F9869F87FB2A9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBA4</accession>
    <name>A0A3Q8IBA4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240013000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBA4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0930"/>
    <dbReference type="OrthoDB" id="267409at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="310" mass="32909" checksum="35345B189385467D" modified="2019-04-10" version="1">MSTHGRSAGDVLARMSDEEDDGVPEDLELTFVPASKRRGPASSHAVGHHAGNAVPSTLTSSTDSGPTVSSNPKPRAETVYERERNAKVRQLLAEQQRTTPGVVFSLDAFEAPPPDQYTLAGFQEAPGTSAPSSSPAPYNREDQRRGFLQYRGRGGAEGGGRGEPSGGGGPRRYRMPNPNMSEEEQARFIRHRRNMAVIRNALREVDPDTLEYMQVTQAPDQLPLNKNRESFSKPYFSTDRGRGGVDAGGGRSMSSYRGRGGGGGMRGRGGSSFSPYSVGRGTGTTRGDGLGRGGGSGGGGRRSAPFSPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBM6</accession>
    <accession>E9BES6</accession>
    <name>A0A3Q8IBM6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1935 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_31455</name>
        <name evidence="6" type="ORF">CGC21_29210</name>
        <name evidence="4" type="ORF">LDBPK_201270</name>
        <name evidence="2" type="ORF">LdCL_200017200</name>
        <name evidence="3" type="ORF">LDHU3_20.1580</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812640">
        <property type="protein sequence ID" value="CAC5429683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000038">
        <property type="protein sequence ID" value="TPP45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860468.1">
        <property type="nucleotide sequence ID" value="XM_003860420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBM6"/>
    <dbReference type="SMR" id="A0A3Q8IBM6"/>
    <dbReference type="GeneID" id="13386258"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1580"/>
    <dbReference type="OMA" id="NRIYPMF"/>
    <dbReference type="OrthoDB" id="269245at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047:SF7">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47047">
        <property type="entry name" value="PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1935" evidence="1">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="133" mass="15080" checksum="1667BE9B65CB0C68" modified="2019-04-10" version="1">MGSGISKEAAPVAFKNGKPTVKGTKTYPMFSNILYRIADTEARRWAFYNDSRELIIHVAVLFDYDSQIVPLGDTTAFRIDDPDEGNEDDFGKYLCEVDVRPLETQMFVEGSVTGWRVDTLEARTAEDERGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBN4</accession>
    <accession>E9BHF7</accession>
    <name>A0A3Q8IBN4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA recognition motif family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_8350</name>
        <name evidence="6" type="ORF">LDBPK_250530</name>
        <name evidence="5" type="ORF">LdCL_250010400</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861383.1">
        <property type="nucleotide sequence ID" value="XM_003861335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBN4"/>
    <dbReference type="GeneID" id="13388630"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0630"/>
    <dbReference type="OMA" id="ADYGPYM"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000658">
        <property type="entry name" value="RNA-binding protein, putative, UPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="240" mass="25348" checksum="8F606ACADF73F833" modified="2019-04-10" version="1">MSAAQNGSATSTPAQQSKPEPIAAPVAGEGSTSGGYAFDPDALRNLIVNYLPPLMNEAQVYELFGQFGRIESVKIIYDKITGESRGYGFVKYQFFFSATYAVSCLNRFEIGGKKLKVAYANAPAAKEAYDMLRLSAVALSMQQQQAMQSMYYHQMVLAQEQQGAPAASSVAASAPMVGGADYGPYMNRVGGGYAMRQRESGAGYARGMYPGMVAGSSVYLAGPSASGSRSITPAIAPIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC54</accession>
    <name>A0A3Q8IC54_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_240021100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1940"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000958">
        <property type="entry name" value="ATP-dependent DEAD/H DNA helicase recQ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000026">
        <property type="entry name" value="ATP-dependent DEAD/H DNA helicase recQ, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="261"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="464"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="845"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1180"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1335"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1416"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1475"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1550"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="983"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1339"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1374"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1488"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1569"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1611"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1632"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1675" mass="178091" checksum="DA516F52FB83E4FF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICE1</accession>
    <name>A0A3Q8ICE1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220022800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.2050"/>
    <dbReference type="OrthoDB" id="268376at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1881" mass="194250" checksum="E3A9F65E010C8500" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICG2</accession>
    <accession>E9BHK0</accession>
    <name>A0A3Q8ICG2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ankyrin repeats (Many copies) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ankyrin_repeats_(3_copies)/Ankyrin_repeats_(Many_ copies)/Ankyrin_repeat_putative/Pfam:PF12796/Pfam:PF13637/P fam:PF13857/Pfam:PF13606/Pfam:PF00023</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_26770</name>
        <name evidence="7" type="ORF">CGC21_8550</name>
        <name evidence="6" type="ORF">LDBPK_250960</name>
        <name evidence="4" type="ORF">LdCL_250014900</name>
        <name evidence="5" type="ORF">LDHU3_25.1230</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861426.1">
        <property type="nucleotide sequence ID" value="XM_003861378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICG2"/>
    <dbReference type="GeneID" id="13388672"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1230"/>
    <dbReference type="OMA" id="ILHRAVW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000616">
        <property type="entry name" value="Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5430671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP48935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="262" mass="27683" checksum="12751681F917A2F2" modified="2019-04-10" version="1">MSLAPSLQLTGLTQAVIQGDLSALMENVTPSNVNYTDPHYRLSLVMWAVALGRLPTTQLLLSRGASLAQVDRQGFTILHRAVWSADVPVIHMVLFTTPMSALASSADARARATGAYTPASSSPSASPSLLTWRPGAQRLVNAVHSATGRTPLMLAALSGQVDVVRYLLVTCAADPYPRDSYGLTAVDLAALCGHLHIVQLLLNLTVAPNGAGGNASDVFPTTQCSAEDYIEIAKTIPQRERLCAVNKLLNENLAEASRVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICU0</accession>
    <name>A0A3Q8ICU0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_260019500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICU0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1700"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000107">
        <property type="entry name" value="Related to DJP1-DnaJ-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="405"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="536" mass="59201" checksum="BC4EE955C41F8BF8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICZ5</accession>
    <accession>E9BIN6</accession>
    <name>A0A3Q8ICZ5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KYNU</name>
        <name evidence="10" type="ORF">CGC21_32405</name>
        <name evidence="9" type="ORF">LDBPK_262250</name>
        <name evidence="7" type="ORF">LdCL_260028200</name>
        <name evidence="8" type="ORF">LDHU3_26.2940</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861810.1">
        <property type="nucleotide sequence ID" value="XM_003861762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICZ5"/>
    <dbReference type="SMR" id="A0A3Q8ICZ5"/>
    <dbReference type="GeneID" id="13389057"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2940"/>
    <dbReference type="OMA" id="LPGWNSH"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="192"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5431062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="468" mass="50696" checksum="472636B6D3CD0F8D" modified="2019-04-10" version="1">MRNAAAETLLSTVSTTGMALTEDGFAEYMDEADPLREHRSSYHIPMMRDGTQFSYFAGNALGPQHVGVEASMAAFLKKWREQAVEGHLMQPTPWFEIDQMCVKDMAAIVGAKDTEVAIMNTPTVNLHLLLSTFYHSQGSKKKIMIDPHSFPSDGYCLLSQLETRGLNPAEDLIKITAPGTKDWNGPVTAIPMEAFLSAIDKRGDETAVIIVSAVQHLTGQWLDIPAIVKAAHAKKILVGVDCAHAVGNVPLHLHDWDVDFAFWCTCKYLSSGPGSIGGVFVHNKHTSGAIPLNHLSRRWGSEIQSCFPKHHSLEPATGASELHISTPSAACYMILAPSLKLMASVGMEAIRQKSLLLTAYLELLLSELVPPGCIEIVTPADPNQRGAQLSLRILPNKLKSGQAAAPGYQCGAGGADEMDDASLLQRQLLDEGVMIHRCSPDVVPVAPAPMYNSFADVLRAVRIIASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID46</accession>
    <name>A0A3Q8ID46_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_240024500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID46"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2320"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000754">
        <property type="entry name" value="Short chain dehydrogenase/reductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF79">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="507" mass="54753" checksum="7071270C0B13D54D" modified="2019-04-10" version="1">MFHFGLRGRLVAMSAASVAAPLNITARRLLFSSGNASSSSAASVTGTRRSSAGAARAPLSSSFTSAPSAGRHKAVKSMLPPAASAAADSIHKFSDDKAEASAYVCGADDVPSYSSASHMSYLMLHSRRLWLPLVLYACYYALSAYLNPVQAGLYATASVVVQRLSVHGRRNKVHKDMTGYTCVVTGGTSGIGLYTAMQLLDMGAHVIIAAPSGKEKETMDFLQRNCLVGAPAATATVASSSASPECEPLENRVTFIAMDYMDQLEVMAAAARIKALTHDRIDLLVNCAGVWKEEPTVTKQKFEEHIGVNFLGPFHFTEALLPSLRKSSHRCGRIVYVTCASHNGVSRGNVVRERMMLLPGPNELQITARCYSASKLGNIYHAQSIANRRYEGIPLNRQSDLHPVDVCCADPGFCFTSLQQANVSPFLGNSIVARTLRSLWIKDAYEGSQTVVNCCVRDTIENGGYYAECALMPSGLSKRAKDPKSRDDVVHWAMAKTIAKYYTVQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID53</accession>
    <accession>E9BHF5</accession>
    <name>A0A3Q8ID53_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein, putative, UPB1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RNA-binding protein, putative, UPB2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">RNA-binding_protein_putative_UPB1/GeneDB:LmjF.25. 0490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_250510</name>
        <name evidence="6" type="ORF">LdCL_250010200</name>
        <name evidence="7" type="ORF">LDHU3_25.0600</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861381.1">
        <property type="nucleotide sequence ID" value="XM_003861333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID53"/>
    <dbReference type="SMR" id="A0A3Q8ID53"/>
    <dbReference type="GeneID" id="13388628"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0600"/>
    <dbReference type="OMA" id="MAMYQQY"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000658">
        <property type="entry name" value="RNA-binding protein, putative, UPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5430624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="167" mass="19005" checksum="90816E120FCB1E45" modified="2019-04-10" version="1">MAQHMAPQQQPPQQPPQQQMYNPEPEALRNLMVNYIPTTVDEVQLRQLFERFGPIEGVKIVCDRETRQSRGYGFVKYHSAASAQQAVNELNGFNILNKRLKVALAASGNQRQRNYNPQQNANPAANMGYYGGNFAAGYPQANPYAQQQMMAMQQQYMMQQPGQQPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDA3</accession>
    <name>A0A3Q8IDA3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_270018100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDA3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1820"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000022">
        <property type="entry name" value="Cation transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018734908" evidence="10">
        <location>
            <begin position="20"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="316"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="610" mass="65201" checksum="15927EB37C4EFD01" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE02</accession>
    <name>A0A3Q8IE02_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_270009200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE02"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0520"/>
    <dbReference type="OrthoDB" id="273594at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="610" mass="67052" checksum="7384AA366268CB03" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE83</accession>
    <accession>E9BLQ8</accession>
    <name>A0A3Q8IE83_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_6925</name>
        <name evidence="7" type="ORF">CGC20_6950</name>
        <name evidence="8" type="ORF">CGC21_35595</name>
        <name evidence="9" type="ORF">CGC21_35620</name>
        <name evidence="5" type="ORF">LDBPK_301650</name>
        <name evidence="2" type="ORF">LdCL_300021800</name>
        <name evidence="3" type="ORF">LDHU3_30.2170</name>
        <name evidence="4" type="ORF">LDHU3_30.2310</name>
    </gene>
    <organism evidence="2 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862877.1">
        <property type="nucleotide sequence ID" value="XM_003862829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE83"/>
    <dbReference type="GeneID" id="13385585"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2310"/>
    <dbReference type="OMA" id="YNIIGSC"/>
    <dbReference type="OrthoDB" id="276226at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP43351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="128" mass="14354" checksum="0AF6E3E8520DF9F9" modified="2019-04-10" version="1">MLRCFNGSMLRPTRGAASLATATAPAAIALPARQFHSVYGIIGSCLMCGACMLCFGSWANNYCNVKKYGRWRFRNSIDDVIMVSDFRGARYFGAFLGFLFWWFVVGPQKYRWNSNLADIPGNTRIGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEG7</accession>
    <accession>E9BG61</accession>
    <name>A0A3Q8IEG7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase GroES-like domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">NADP-dependent alcohol dehydrogenase, putative</fullName>
            <ecNumber evidence="7">1.1.1.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NADP-dependent_alcohol_dehydrogenase_putative/Gen eDB:LmjF.23.0360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_18380</name>
        <name evidence="10" type="ORF">CGC21_17485</name>
        <name evidence="9" type="ORF">LDBPK_230410</name>
        <name evidence="7" type="ORF">LdCL_230009600</name>
        <name evidence="8" type="ORF">LDHU3_23.0600</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860942.1">
        <property type="nucleotide sequence ID" value="XM_003860894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEG7"/>
    <dbReference type="SMR" id="A0A3Q8IEG7"/>
    <dbReference type="GeneID" id="13389903"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0600"/>
    <dbReference type="OMA" id="EAIFPMV"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP50314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP51384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="352" mass="38458" checksum="49AB9BB36192AF73" modified="2019-04-10" version="1">MPTEAHGWAALSAKSKLEPFTFQRRDVGPDDVVINIAYCGVCHSDVHQARDEWDGSTFPMVPGHEIVGHVTKVGSEVTKYKAGDRVGVGCMVDSCMKCRQCERGLEQYCVNGASFTYNSTQQDKKTPTFGGYSDHVVVREHFVVSIPDNLDLCAAAPLLCAGVTTFSPLRYWGVKKGTRVGVVGLGGLGHMAVKLANAMGAEVTVFTRSSNKVEEAKNLGAHHVVNTNNEQEMNSIQGTLDVIVDTVGMSHDLRPYMMTLDIDGKLALVGMPEHAHPPLDPRRIIASRQCVGGSNIAGMPETQELLNFCGEHNITATVEKISIECINEAYERMLASDVRYRFVIDMASLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEI9</accession>
    <name>A0A3Q8IEI9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_300039800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEI9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300039800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4520"/>
    <dbReference type="OrthoDB" id="268010at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="624" mass="64749" checksum="CABEBBA970659493" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEW7</accession>
    <accession>E9BMU2</accession>
    <name>A0A3Q8IEW7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GINS complex family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GINS complex subunit Psf3, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">GINS_complex_subunit_Psf3_putative/GeneDB:LmjF.31.1660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_3295</name>
        <name evidence="10" type="ORF">CGC21_11400</name>
        <name evidence="8" type="ORF">LDBPK_311680</name>
        <name evidence="6" type="ORF">LdCL_310024000</name>
        <name evidence="7" type="ORF">LDHU3_31.2930</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863259.1">
        <property type="nucleotide sequence ID" value="XM_003863211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEW7"/>
    <dbReference type="SMR" id="A0A3Q8IEW7"/>
    <dbReference type="GeneID" id="13389433"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2930"/>
    <dbReference type="OMA" id="DVREKLC"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="77"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5432591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP41449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="186" mass="20886" checksum="13BD6CED8CE693F0" modified="2019-04-10" version="1">MIRSYFDLDDIGACEEPVAVTFTVPSFSMGKDLTVRTHEGETVSEVVAGCVATVPLWAATALRTEGYVSVHAPHTFSLATFREFKTDPLAPSLHRKSPYFYQAGLQLCRLLSNPTSSGHMSAEGNRLAAQLFRLYQLRYLRIIFAAAKKGFDLNDVRDKLEESERHLLDSYLRGQAEEALWYANFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFU8</accession>
    <name>A0A3Q8IFU8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine rich repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_260017600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFU8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1490"/>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="668" mass="72807" checksum="5F51AC4870108A7A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFV8</accession>
    <accession>E9BNP2</accession>
    <name>A0A3Q8IFV8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PPPDE putative peptidase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">PPPDE putative peptidase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_20250</name>
        <name evidence="7" type="ORF">LDBPK_321390</name>
        <name evidence="6" type="ORF">LdCL_320019600</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863555.1">
        <property type="nucleotide sequence ID" value="XM_003863507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFV8"/>
    <dbReference type="SMR" id="A0A3Q8IFV8"/>
    <dbReference type="GeneID" id="13390605"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1760"/>
    <dbReference type="OMA" id="NCVFHTK"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="159"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP43651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="630" mass="69545" checksum="5BB7FCC31DF7976F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG83</accession>
    <accession>E9BNW3</accession>
    <name>A0A3Q8IG83_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_20600</name>
        <name evidence="6" type="ORF">LDBPK_322110</name>
        <name evidence="5" type="ORF">LdCL_320026500</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863625.1">
        <property type="nucleotide sequence ID" value="XM_003863577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG83"/>
    <dbReference type="GeneID" id="13390913"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2620"/>
    <dbReference type="OMA" id="MGPVEML"/>
    <dbReference type="OrthoDB" id="10264063at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="4">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="689"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="382"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="731" mass="80598" checksum="181306BF13224377" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGD8</accession>
    <accession>E9BUB6</accession>
    <name>A0A3Q8IGD8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_364080</name>
        <name evidence="2" type="ORF">LdCL_360047800</name>
        <name evidence="3" type="ORF">LDHU3_36.5470</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865522.1">
        <property type="nucleotide sequence ID" value="XM_003865474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGD8"/>
    <dbReference type="GeneID" id="13388408"/>
    <dbReference type="KEGG" id="ldo:LDBPK_364080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360047800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5470"/>
    <dbReference type="OMA" id="HMRNVRV"/>
    <dbReference type="OrthoDB" id="272179at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000015">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="394" mass="43658" checksum="68560D3D27B916DA" modified="2019-04-10" version="1">MWCLKRVPRGPSLARGSAAIVGMPRRFRAVQEASVLCSLTVVAHGRRTLSTEELVDEETQWTRAMGSKYGFGNYQLFRALYKDLCDEIRREYYTKPPPPPPATRTTGVSPSLAAPEASPEVHGGADSGANDTSSGATKHSSVAGGADATSSLTQGGGMPAASQREDSTGETARAARETAATPPSQPEETYGDGSWSVQHRPEDNVVVFHRGAVKRGRLAAVHAWARIELKDPPRLNAVLTFADWIPIEVCVERNGIVIHFSMASNEGGMHMRNVRVYAPKSAEERAVLLDPSDDGEYARKNFYYDGPCLWHLELDMLNELYDVMQDHGVTLDWIRWAASWVFYLEHVNYLRWNLGMLEELIPSSLRGPEEDFLLPVEKALLAEPVEDWLRAHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGI5</accession>
    <name>A0A3Q8IGI5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_250014500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGI5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1190"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000852">
        <property type="entry name" value="Ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="256" mass="29071" checksum="12739CEC5F0D830A" modified="2019-04-10" version="1">MKRLSNHHAIVCGAASAIAAVAAASARSGDVVGGDSSCTATSPLLTAKRGRFYRPLVNQGINLWRSRMGRLHKGWTTWEYNRDVIPDPRPFPEPAVNNYFGRSRIWNPIAGKIGLVNRKAEEWGWPHQRPPPTGLRRSPEYFPFFFSRYFPDVEVRLVLDSVLNNETTRPIFHIPQDMSKQELVNYLKNIYNIDNVVRISVRNMRGRRFKNEVGEIKSLPDYKVAVVELDSPVSIVFKQIKGTEDTPDNKPVAQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGQ5</accession>
    <name>A0A3Q8IGQ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein DMC1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Meiotic_recombination_protein_DMC1_putative/GeneD B:LmjF.35.4890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_350054500</name>
        <name evidence="13" type="ORF">LDHU3_35.6480</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGQ5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350054500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6480"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000075">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="120"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU83294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5434516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="362" mass="39253" checksum="A3B1B1A159B6DB3D" modified="2019-04-10" version="1">MHQQQQRQHSSHFAEERVGDCGAAFAEPQPLHNSVTGEAAGQPLLEVERLAEHGIGAADITKLKQAGIFTVPGVQMQCRKDLIQIKGLSEAKVDKIIEAARRVSEVGFITGSSCLQQRSTILRISTGSVALDQLLGGGGIESRSITEAFGEFRTGKTQIGHTLCVTCQLPLEMGGGNGKAVYVDTEGTFRPERIRPIAERFGMDSNSVLDNILVARAYTHEHQAHLLSMVAAKMAEDQFSLLVVDSITALFRVDFSGRGELAERQQKLAKMLSQLMKIAEEFNIAVYITNQVVSDPGGASMFVADPKKPVGGHILAHASTTRLSLRKGRGDQRVCKIFDSPSLPELECVYSISEQGIIDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHE5</accession>
    <name>A0A3Q8IHE5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320042700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHE5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320042700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4650"/>
    <dbReference type="OrthoDB" id="272215at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="636" mass="67349" checksum="ECF076ED19A11FD3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHV5</accession>
    <name>A0A3Q8IHV5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_280005400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHV5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0070"/>
    <dbReference type="OrthoDB" id="7760980at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="109"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="488" mass="56095" checksum="6A2D3F815708272F" modified="2019-04-10" version="1">MRAEESERRCRQLMLLQSRLREVVAEEREMSNAVSGAIDARWMRFLRECKQRELVAEIEVLRRTFEATLDRKEGFSTTLLEELSVAEEQCRHAFRSHMDVVSSLLQLHAERTKDLEADLDANVAEMQQDFEYERAELELKHMIEMDDLRLILDNMAAEAEMLEKRLQEETSEGHETAAEKMDEAMREMEADLNKVEDGLRGELDSRYKKFMSTAQANMKEYTAKCKEDQETTERIAAQLRKIEKLQNSVSSWRTNIARNAKEWEGRNAAIEAERDATLSHLKKLKDKMQRWREMQSKALVELVKEANATEEALQATSKRAVRLLRLVELCKPMETEREQVLLHEANISSAAVEAETKRRVAAEGSVNAQDDVLSGVDAAPAANEQWLSLDRFWVKHNKVVLDNAALTQERFLLQEENRVLQEVLKQYLDDVSVSDQVMRQSNTLLLTQAANRNVVQAAKAGDSSVVRGYNVIEGNKFVNDQSRQVVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHW3</accession>
    <name>A0A3Q8IHW3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc knuckle, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340049400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHW3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_344000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340049400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6310"/>
    <dbReference type="OrthoDB" id="262726at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16614" checksum="B148D7661DA49B96" modified="2019-04-10" version="1">MYGDKGPPKGYSVPRFDTNASKRCQTCSSTEHWTFECPLKKSATSSAKKGAAATVKLSPSQMLRYGIKRKSANFVPEPTEREVFDAELRELRNMLTAEVRQELKAKKFAAHKSGNDCKMHEAPLPSAAPKKESPSAPVKIKKERTEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHZ1</accession>
    <name>A0A3Q8IHZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intraflagellar transport (IFT) protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_300025300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHZ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2730"/>
    <dbReference type="OrthoDB" id="10254896at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="129" mass="15499" checksum="E136A5839BFA6741" modified="2019-04-10" version="1">MDEDRLIMFDNNGAIRMYDPEKYDELVKTVEVERRYVEKMDEFRALVQRTMAIVQRLGEAIEAEKLKAIGFRNIVESESEERFRAVQEAQIRLREKQMELDRYVAEYESLKLVEQEQQTFFQHLSQAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II69</accession>
    <name>A0A3Q8II69_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L26, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">60S_ribosomal_protein_L26_putative/GeneDB:LmjF.24.2050/GeneDB:LmjF.35.1670</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_0205</name>
        <name evidence="11" type="ORF">CGC20_12415</name>
        <name evidence="13" type="ORF">CGC21_16650</name>
        <name evidence="10" type="ORF">CGC21_6345</name>
        <name evidence="6" type="ORF">LdCL_240027000</name>
        <name evidence="7" type="ORF">LdCL_350021600</name>
        <name evidence="8" type="ORF">LDHU3_24.2590</name>
        <name evidence="9" type="ORF">LDHU3_35.2210</name>
    </gene>
    <organism evidence="7 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II69"/>
    <dbReference type="SMR" id="A0A3Q8II69"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2210"/>
    <dbReference type="OrthoDB" id="260276at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5434189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP52335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="143" mass="16176" checksum="9B06BC46E9E35EE0" modified="2019-04-10" version="1">MASIKCGSRRKARRAHFQAPSHVRRVLMSAPLSKELRAKYNVRAMPVRKDDEVIVKRGTFKGREGKVTACYRLKWVILIDKVNREKANGSTVAVGIHPSNVEITKLKLTHHRKSILERKDRSSKSDKGKGKISAADKAMQQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8III5</accession>
    <name>A0A3Q8III5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pentamidine resistance protein 1</fullName>
            <ecNumber evidence="13">3.6.3.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_310020000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.44" evidence="13"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2160"/>
    <dbReference type="OrthoDB" id="262778at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000082">
        <property type="entry name" value="ABC transporter, multidrug resistance associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002055">
        <property type="entry name" value="ATP-binding cassette protein subfamily C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="272"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="603"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="959"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1553" mass="168858" checksum="590127FCD7C09C64" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJY7</accession>
    <accession>E9BPY8</accession>
    <name>A0A3Q8IJY7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_11125</name>
        <name evidence="5" type="ORF">CGC21_38295</name>
        <name evidence="4" type="ORF">LDBPK_330590</name>
        <name evidence="2" type="ORF">LdCL_330011400</name>
        <name evidence="3" type="ORF">LDHU3_33.0870</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863883.1">
        <property type="nucleotide sequence ID" value="XM_003863835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJY7"/>
    <dbReference type="GeneID" id="13392280"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0870"/>
    <dbReference type="OMA" id="HDRELCE"/>
    <dbReference type="OrthoDB" id="256733at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="144" mass="15961" checksum="2DB2253BDE71417C" modified="2019-04-10" version="1">MGQSFDLLRTHDEVPDDVKAAIPPIKYTAAPEESRPHNRELCEDCGEYFGWFCWSTNCDWCGRQLCARCCPNHHLLGGNPGCKDCTRKAFRIRRQAMLEDHLQNAGLPLQRPRGRAAEGEPITTASGALESVDALAPSKARIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMS2</accession>
    <name>A0A3Q8IMS2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_330039400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMS2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330039400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4680"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="682" mass="74069" checksum="2E4D8CA9462E7C07" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPY5</accession>
    <accession>E9BJ65</accession>
    <name>A0A3Q8IPY5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_30750</name>
        <name evidence="6" type="ORF">LDBPK_271330</name>
        <name evidence="5" type="ORF">LdCL_270020100</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861986.1">
        <property type="nucleotide sequence ID" value="XM_003861938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPY5"/>
    <dbReference type="GeneID" id="13386720"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270020100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2060"/>
    <dbReference type="OMA" id="EGVCHND"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000893">
        <property type="entry name" value="Choline kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="639" mass="71962" checksum="66CD9B5579F10ECC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IT33</accession>
    <accession>E9BNH2</accession>
    <name>A0A3Q8IT33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AKAP7 2'5' RNA ligase-like domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">AKAP7 2'5' RNA ligase-like domain/2'-5' RNA ligase superfamily, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">AKAP7_2'5'_RNA_ligase-like_domain/2'-5'_RNA_ligas e_superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_33655</name>
        <name evidence="5" type="ORF">CGC21_19900</name>
        <name evidence="4" type="ORF">LDBPK_320680</name>
        <name evidence="2" type="ORF">LdCL_320012300</name>
        <name evidence="3" type="ORF">LDHU3_32.0840</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863486.1">
        <property type="nucleotide sequence ID" value="XM_003863438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IT33"/>
    <dbReference type="SMR" id="A0A3Q8IT33"/>
    <dbReference type="GeneID" id="13390298"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0840"/>
    <dbReference type="OMA" id="KEMHDAM"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1140.10:FF:000011">
        <property type="entry name" value="AKAP7 2'5' RNA ligase-like domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="282" mass="31387" checksum="DEA5BE929F880FF8" modified="2019-04-10" version="1">MWTQCSRALRGRSERGLYFPINHRIVDQRNTLASGAEEADIQSRYRRQLRSSFVTRETRQTEPPAWSRSTRPTHFLSLPLPSRCTLRVRVKEMHESMIFANQSIEPLLIPASKLHVTLGVMTIGGETATAEAASAAAAPDVLAAIQDCVDQACHDTCKEPLQLRFRGLGTFGHGRVLFAGCITEAHFTTLDTLVRRIRKDLGLGLGVDMKGNPHDSYVPHVTVAKIRPSQIGQFGRQLPISMWADHQHHDFGDVTFNRVDLCSMKGEGKNGYYHVVSSAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVS9</accession>
    <accession>E9BTF5</accession>
    <name>A0A3Q8IVS9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF6</name>
        <name evidence="9" type="ORF">CGC20_29450</name>
        <name evidence="10" type="ORF">CGC21_12800</name>
        <name evidence="8" type="ORF">LDBPK_360950</name>
        <name evidence="6" type="ORF">LdCL_360014500</name>
        <name evidence="7" type="ORF">LDHU3_36.1250</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865212.1">
        <property type="nucleotide sequence ID" value="XM_003865164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVS9"/>
    <dbReference type="SMR" id="A0A3Q8IVS9"/>
    <dbReference type="GeneID" id="13388097"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1250"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5434664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP48210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="249" mass="27085" checksum="84CFF1B4C44B95EB" modified="2019-04-10" version="1">MTLRTRFESSDDIGVFSRLTNAYCLVAAGASQNFYSVFEQELANHICVVYTSIGDARVIGRLTVGNRHGLIVPSITTDQELQHLRNSLPDSVKVQRVEERLSALGNCVVCNDHVALIHTDLSRETEEVIRDTLQVQTFRTSIAENALVGSYAVATNKGCMVHPKTPAQDMDEISSLLQVPVVAGTINRGNAAIGSGLVVNDWAAFCGLNTTATEITVVERIFQLRREAAGGDEGNLLQNVRETLVDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H597</accession>
    <accession>E9B7Z8</accession>
    <name>A0A3S5H597_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial exoribonuclease DSS-1, putative</fullName>
            <ecNumber evidence="4">3.1.13.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RNB domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_2600</name>
        <name evidence="5" type="ORF">LDBPK_040320</name>
        <name evidence="4" type="ORF">LdCL_040008700</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.1" evidence="4"/>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858095.1">
        <property type="nucleotide sequence ID" value="XM_003858047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H597"/>
    <dbReference type="GeneID" id="13390706"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0390"/>
    <dbReference type="OMA" id="DMLVHHQ"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF60">
        <property type="entry name" value="MITOCHONDRIAL EXORIBONUCLEASE DSS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600556" evidence="2">
        <location>
            <begin position="17"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="238"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="854" mass="93783" checksum="571ADAD2C92A7E72" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5D7</accession>
    <accession>E9B861</accession>
    <name>A0A3S5H5D7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_9500</name>
        <name evidence="13" type="ORF">CGC21_2910</name>
        <name evidence="11" type="ORF">LDBPK_040960</name>
        <name evidence="9" type="ORF">LdCL_040015200</name>
        <name evidence="10" type="ORF">LDHU3_04.1200</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812624">
        <property type="protein sequence ID" value="CAC5427229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000063">
        <property type="protein sequence ID" value="TPP43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858158.1">
        <property type="nucleotide sequence ID" value="XM_003858110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5D7"/>
    <dbReference type="SMR" id="A0A3S5H5D7"/>
    <dbReference type="GeneID" id="13391006"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.1200"/>
    <dbReference type="OMA" id="GTQCDRM"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU75876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5427229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP51514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="209" mass="23042" checksum="5D4713395689EF3C" modified="2019-04-10" version="1">MSGETQQQQPQGMTPLKVFFILGGPGSGKGTNCARLVEDFGYTHFSAGELLREAARSGTGNLAKIGDIIRSGNIVPSEITVELLRQAIADHPNSVGYVIDGFPRKEDQARMFEEGIAKPTGILYYDCSEATMEERLLSRGANSGEKRDDDAAETIRHRFRVNVQECMPVVEAYKANGRCHVIDANRDRDTVYADTKKVFLEMGEKPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H641</accession>
    <accession>E9B9D6</accession>
    <name>A0A3S5H641_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isochorismatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Isochorismatase family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Isochorismatase_family_putative/Pfam:PF00857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_23295</name>
        <name evidence="7" type="ORF">CGC21_0470</name>
        <name evidence="6" type="ORF">LDBPK_080310</name>
        <name evidence="4" type="ORF">LdCL_080008000</name>
        <name evidence="5" type="ORF">LDHU3_08.0370</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858596.1">
        <property type="nucleotide sequence ID" value="XM_003858548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H641"/>
    <dbReference type="SMR" id="A0A3S5H641"/>
    <dbReference type="GeneID" id="13391915"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0370"/>
    <dbReference type="OMA" id="HETIHVT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="47"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5427680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="252" mass="28296" checksum="24F2C13D4C8F02BE" modified="2019-04-10" version="1">MAHTGGAGTLCEKAPATAERPTSDVTVPQRRRHATQLLRKFTECRTLFMCCDIQEKLAEKIPGFNETIRITNDLTLFCEMLGPTYCNVLATVQYPAGVGPLYHEIQLPPSAPVIPKMEPSMLLPEALPYLYGDADHGILPVQQVVLWGHETHICIMQTADELLRRGFRVAIATDGCAAQRRLDHEVAIMEMSKWEGLLLTNSIGVYTMIVRADDSVWKPVMQLIRDGAHAFKRPYERSEDPTVPPQERERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H661</accession>
    <accession>E9B9G7</accession>
    <name>A0A3S5H661_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_0350</name>
        <name evidence="4" type="ORF">LDBPK_080620</name>
        <name evidence="3" type="ORF">LdCL_080011200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858627.1">
        <property type="nucleotide sequence ID" value="XM_003858579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H661"/>
    <dbReference type="GeneID" id="13391925"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0680"/>
    <dbReference type="OMA" id="HHFKHSE"/>
    <dbReference type="OrthoDB" id="267729at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="143" mass="16077" checksum="25BE5B72971C71E5" modified="2019-04-10" version="1">MEAGHGCRAARQPKRLLTALFVAAALLAAFGGALLVAQAEVETPEPTPYVRRTYEVKVPFFTQYWWVGFIIMILVLLLVVMVLYAAVQHHFKHSEQLRRRKEIEMSRMHIESGSGDDDARSQGAGQYSRSGRSSYSNPLRTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H703</accession>
    <name>A0A3S5H703_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170010100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H703"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0750"/>
    <dbReference type="OrthoDB" id="244476at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="113570" checksum="E4DD1420D596A932" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7C9</accession>
    <name>A0A3S5H7C9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_240012100</name>
        <name evidence="9" type="ORF">LDHU3_24.0840</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7C9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240012100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0840"/>
    <dbReference type="OrthoDB" id="263929at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5430401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="989" mass="105370" checksum="62B8CE825AF111A9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7M4</accession>
    <name>A0A3S5H7M4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spliceosome-associated protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Spliceosome-associated_protein_putative/GeneDB:Lm jF.30.0570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300011000</name>
        <name evidence="4" type="ORF">LDHU3_30.0770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7M4"/>
    <dbReference type="SMR" id="A0A3S5H7M4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0770"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="474" mass="51125" checksum="80E9D8FD65EE466F" modified="2019-04-10" version="1">MAKSKKEKKAARREREAHLKKISQRIQEKILLAEVATAEGEVEEIVYTLPPTPAELRAAEEEQERQQAAIAAEAEERAAAAAAAKAAQAAAAASAEKDEEDRVVLPSLDGGEGGAKGCRHSSSALSGRKHHRMTWEELKLRAAEMYGLEATELVDQHDGNAVDPLFTVRMKMEPHTVPVPHHWHLQRTFLSRQADREEAVGIVPAEVAALGIEKIRATKDKMATPNQVAFISCFMTGTPLQRKTYNVELSRCGDVFYEGKWRPKAHHTPGVLSKRLRQALGIGPTAPPPWLYSMQTMRRLPPAYPDLRIPGLNAPIPAGGQWGLGQDQWGEPPRAEDNSFLFPGVMDEAAAAGSTQAELRWGTVPPLVTSHEEVPSAAGASSSGAASPAPATAAQALPRPTPAAGRPVITPVPFQPQAYVPQQAVPAARVTPQEYVQVQDNTTNSTVAVGYMMMPKDGVQSQPPPSRYPPAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNL4</accession>
    <accession>E9B7E5</accession>
    <name>A0A3S7WNL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_010820</name>
        <name evidence="5" type="ORF">LdCL_010013300</name>
        <name evidence="6" type="ORF">LDHU3_01.0930</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812621">
        <property type="protein sequence ID" value="CAC5426956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857894.1">
        <property type="nucleotide sequence ID" value="XM_003857846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNL4"/>
    <dbReference type="GeneID" id="13389740"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0930"/>
    <dbReference type="OMA" id="QGHYALH"/>
    <dbReference type="OrthoDB" id="273792at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23672">
        <property type="entry name" value="MPSS5_OBF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU75594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5426956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ31168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="490" mass="51845" checksum="ECD31615F7F83E67" modified="2019-05-08" version="1">MLLSRHPDLLMSRAASIPSAAARWCLALALPLPTASSLSLRSAATVVESHQDDRPRLAPVAVLSAIALTNSRRLSAAPHSLPFLYRRPSGLRARCNSGNGCRSILLAPPSPASAGAAAASVSVTTPTPSASAPARRERHVCPECGKRFLCEPNLARHRATRHGVQVASASEVARAQIAARNARLQQELARVQARVRQLREGSGTAATAELAVDAASAYPSAVLTGRLMEIDEAVERAWRHSGRGLGTGVSFVSCVGTVRGPVEVGTLRGATPASASDSPAAGPRVLQFVLEAHGYRERRPGQLKMYRSHLLVRYVAWQPYHRYGDDDGAGSAAAPPPPATAPLLFKVQEGDLLRVQGHYALHSSYDMISKQSVENVVLEADAVGMLRPAPAKEASKAQSERDGSPTQQPFLSAPPPSRYATTPTDEDLISRAHDRCPGQDSAMSAAPPAAAAAVASADVLSPKQRQPILSARKKTTTKRSTTSPLKPQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPK6</accession>
    <accession>E9B8X4</accession>
    <name>A0A3S7WPK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_24040</name>
        <name evidence="4" type="ORF">LDBPK_061140</name>
        <name evidence="3" type="ORF">LdCL_060016500</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858420.1">
        <property type="nucleotide sequence ID" value="XM_003858372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPK6"/>
    <dbReference type="SMR" id="A0A3S7WPK6"/>
    <dbReference type="GeneID" id="13391695"/>
    <dbReference type="KEGG" id="ldo:LDBPK_061140"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_061140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1290"/>
    <dbReference type="OMA" id="YWGNIAG"/>
    <dbReference type="OrthoDB" id="271982at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043645">
        <property type="entry name" value="pATOM36"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19224">
        <property type="entry name" value="pATOM36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="302" mass="32277" checksum="1C2DDB2DFB61CB6F" modified="2019-05-08" version="1">MLQAATNSNVLPLSGGRSALNHGYSMHTLARKRFRENTSALAVTVGFVLPALNGVNKQLDKHVDAGTDVSMDELMQIFAKSGKDAAALYADRMARIACQTGLACALIESKSAYCNAAVYLWDLYPRLHQRYVGAVLSWLRIPVFVSSLLGPHPTTQDVAFLQARVSGVCAFEDSLRRDTITLFGDLLVDTARILIRRDVDNPSEAVARQAVLRVTVTVVGAVGAGLGRAAAGERGEYWGNIAGVMAGPAVAVQLWTAVRKMRMLRPRRAVDATKSHRHRHSTSEGSRAAAATAGGAPATAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQX5</accession>
    <name>A0A3S7WQX5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_090022300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQX5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090022300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1860"/>
    <dbReference type="OrthoDB" id="275832at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="121" mass="14121" checksum="13B723BEE1ACFEFB" modified="2019-05-08" version="1">MKLVRRARKSIRERRMKACINDLNSNLSKVEMRVFRKQKKERDAKRQALGISELVPKDVLNGRMNPDLYAVECRLHEEAGLPKPLPYQGYKEDLLRSRATTHCVGFVGFRTILQAIRARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRX1</accession>
    <accession>E9BB14</accession>
    <name>A0A3S7WRX1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_9875</name>
        <name evidence="3" type="ORF">LDBPK_120340</name>
        <name evidence="2" type="ORF">LdCL_120009000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000044">
        <property type="protein sequence ID" value="TPP43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859151.1">
        <property type="nucleotide sequence ID" value="XM_003859103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRX1"/>
    <dbReference type="GeneID" id="13390159"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0520"/>
    <dbReference type="OMA" id="PVETCGA"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="416" mass="43962" checksum="CFFFF1600B929775" modified="2019-05-08" version="1">MVSMIVAGATGAIGRTVVQYAIQQPSIDRVVALTRFRNTAVSNYEHLFGIIVAGEAGNTDSRGEGANSKREKGSKFPAGTVTATPAEAAKIRPITMDWEEFTQLWVAKRSSTCAAASGADNRAAGAAATAITDPMERYRGIFGGHTYAAMCLGTTRKDAGSAKSFTRCDYDYVMAFTEAVLAYSAPAGLSPDKTFVHHIGDGGVSKQVHVQEGMGKEVDVLAAMNDNAAQSSGTLRVFCQVSSSNASSSSWFLYMKTKGIADESTVERVHRHNKLATAAAALSPVNLLLLQPGLLERHGKTRTTEKFAKLIMSSIPVETCGAAIVSACKSLPIQRSVQRAEATSAAELAKHDEVEGAQVEKESSTVAAGVRKTPLGKPYVGAKALRKAGIPSNEPLPYIYEANNAVITDLASRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRY9</accession>
    <name>A0A3S7WRY9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pumillio protein 4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_120008900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0510"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF50">
        <property type="entry name" value="RNA BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1290"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1331"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1477" mass="154853" checksum="E33DFA6035C64FB1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WS51</accession>
    <accession>E9BB48</accession>
    <name>A0A3S7WS51_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_18095</name>
        <name evidence="3" type="ORF">LDBPK_120661</name>
        <name evidence="2" type="ORF">LdCL_120018600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000048">
        <property type="protein sequence ID" value="TPP49670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859185.1">
        <property type="nucleotide sequence ID" value="XM_003859137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WS51"/>
    <dbReference type="GeneID" id="13390171"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120661"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120661.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1070"/>
    <dbReference type="OMA" id="TWDEEWI"/>
    <dbReference type="OrthoDB" id="258902at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36219">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36219:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="439" mass="50700" checksum="EB06E001AD52F4F5" modified="2019-05-08" version="1">MLRCAPSKLFRATPLLRVWAAEEDDASAPRTTFRNVRPGRLLRLWRQMRHRAWILYAWDEEWVSPMQEGYLHQQRLEQVCFAPLSAYGMVPGSYCDPLLYNTKSTSPFRWHVANVQGDIVGHWYMDADELFRIKDWQPRNPDDPLEMFPRPPQMLLRWDESVDEHGNRAFRYRYDYDMMGPTGKWEAYPRYPFSHLYHGGPDQHGRAEGYGFQQGHLLRCDEAEEEVLRRIMEGEDREWEMVKRTEAVQEPWSYPGKIRPRDFEGAVERAKARFRERVRHGRETDPSEDPEYDLAQASEYVEPRDGRRAEWRHLWASGRKPGESLPFQVTFNDGLCFEENEGGPPAHPAAHYEATPKGAPHGRYEDADAAAARAAEAAHKAACEQSLSEAMERHRRLFGDTSGEPSGPRAPLPTGCRPMRCAPGPPLPSGRRRSSAPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSD6</accession>
    <name>A0A3S7WSD6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar radial spoke protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_130008600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSD6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0440"/>
    <dbReference type="OrthoDB" id="272202at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD 6 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159">
        <property type="entry name" value="RADIAL SPOKEHEAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="602" mass="67067" checksum="B5FC27FD83D7A06A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSH4</accession>
    <name>A0A3S7WSH4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_130014100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1090"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000165">
        <property type="entry name" value="AMP deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000233">
        <property type="entry name" value="Putative AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000236">
        <property type="entry name" value="Putative AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1890" mass="207248" checksum="22BD1904CA5B6FFC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTX7</accession>
    <name>A0A3S7WTX7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypanosoma Tc-38 (p38) protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_160011900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTX7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0810"/>
    <dbReference type="OrthoDB" id="266271at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypanosoma Tc-38 (p38) protein" evidence="2">
        <location>
            <begin position="248"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="674" mass="71154" checksum="530B761CF8A83323" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU67</accession>
    <accession>E9BD22</accession>
    <name>A0A3S7WU67_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_37005</name>
        <name evidence="8" type="ORF">CGC21_24580</name>
        <name evidence="6" type="ORF">LDBPK_161710</name>
        <name evidence="4" type="ORF">LdCL_160022100</name>
        <name evidence="5" type="ORF">LDHU3_16.2040</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5429029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859855.1">
        <property type="nucleotide sequence ID" value="XM_003859807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU67"/>
    <dbReference type="SMR" id="A0A3S7WU67"/>
    <dbReference type="GeneID" id="13393228"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160022100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.2040"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5429029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="268" mass="30230" checksum="53D01B90F69C7B05" modified="2019-05-08" version="1">MSKLLQKVAIGAMAAGLSVYSCCFVVYPGEACILYNKISGLKDSVYGEGLQGRIIGLDEVLRFNVRVRPRTLHTMTGTKDLQMVNVRLRVLFRPMADRLPQIYRTFGLDYDERILPSVSNEILKAVVAEYKAEELIQKRDAVSARIYQLMQEKVNQFGLIIEDLSLVDIQFGADFMTAVEQKQVAQQEAERYRYVVMENEQKRRAAVVRAEGEAESARLISEAIQKSGSGLLELRRIEAAVEVANQIVPMQNVTFVPKDANMLMSMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUI6</accession>
    <name>A0A3S7WUI6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170017400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUI6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1580"/>
    <dbReference type="OrthoDB" id="272158at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="822" mass="87741" checksum="2863DB7C75D7FCB4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVF9</accession>
    <name>A0A3S7WVF9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UvrB/uvrC motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_190007400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVF9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0280"/>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001165">
        <property type="entry name" value="UvrB/uvrC_motif_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="415"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="875" mass="94775" checksum="716BE12D3991E3BF" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVZ2</accession>
    <name>A0A3S7WVZ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_200009000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVZ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200009000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0500"/>
    <dbReference type="OrthoDB" id="1883418at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211:SF3">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="934"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136173" checksum="0BA1F443DCF160D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWA6</accession>
    <name>A0A3S7WWA6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglycan beta 1,3 galactosyltransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_210005000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWA6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5600"/>
    <dbReference type="OrthoDB" id="262898at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="814" mass="90954" checksum="FAD172C80C9E2ED7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX82</accession>
    <name>A0A3S7WX82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_220018100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX82"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1580"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="367"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="452" mass="47279" checksum="A7B9502914CB94F6" modified="2019-05-08" version="1">MFTQISNAHTEVVTSLVFSPHVVTTGEGGLLCSTSGDDTTALWDLRAGPGASQRAAHLTGHHVGPVNHALFHPSNAYTLLTASDDRSIGCWDLRRPDRVVGTVSGFQEGVNKMLWLPVTSDGCRGTGGSSSGGGWRVVSACDDGHVYIHALSLSNSGSESVTVADTAPVPQVGALVDKFRVSTSTVNDIVLAPNSISILITASEDCALRSWSLRHAQQMTNTSVGLMEDRLLATLDEFENPVNHVVVVPSGLMAPVESRAAGEGPESGSSRSLDGAAGDAEECADAASASTGFPRAYQQVHGGNVVEDAEAGSDTGSSAGARQPRRATDISEAAGTGCWLLAACSECVFGVDFTLRIGEFGTGARAFVGHQDYVRGLEFTSEGKLLTVSDDSTAIEWDLATTDPIRQVKLHDGLVMSSAVSPSRDLLATGTDRGELRVWRLPFATERIGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXG4</accession>
    <accession>E9BG48</accession>
    <name>A0A3S7WXG4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_18440</name>
        <name evidence="15" type="ORF">CGC20_18460</name>
        <name evidence="12" type="ORF">CGC21_17540</name>
        <name evidence="13" type="ORF">CGC21_17560</name>
        <name evidence="11" type="ORF">LDBPK_230280</name>
        <name evidence="8" type="ORF">LdCL_230007700</name>
        <name evidence="9" type="ORF">LDHU3_23.0380</name>
        <name evidence="10" type="ORF">LDHU3_23.0430</name>
    </gene>
    <organism evidence="8 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860929.1">
        <property type="nucleotide sequence ID" value="XM_003860881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXG4"/>
    <dbReference type="GeneID" id="13389890"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0430"/>
    <dbReference type="OMA" id="IKFYHVL"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5430160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5430164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP50325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP50329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="189" mass="20974" checksum="0B495C82698F7DDC" modified="2019-05-08" version="1">MLNEVHVNADPNTISTLDEPVLQTLLRDAKAIGRKLVVVVCPPLGADKELHDWDLWGPLFLCLILASILTINASDDQGAAVFSAVFIFVWLGGLVVTVNAKLLGSKIMFFQTYCAIGYCLAPICLGALLCCVLPWFLLNLLLCFIAWAWACWAALRFFRNTVSADREVLVVYPVGLFYIFFTWMVLVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXV0</accession>
    <accession>E9BGE9</accession>
    <name>A0A3S7WXV0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_17045</name>
        <name evidence="3" type="ORF">LDBPK_231350</name>
        <name evidence="2" type="ORF">LdCL_230020600</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861028.1">
        <property type="nucleotide sequence ID" value="XM_003860980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXV0"/>
    <dbReference type="GeneID" id="13390228"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1790"/>
    <dbReference type="OMA" id="HYTRGTI"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48585" checksum="E05295D04143AE16" modified="2019-05-08" version="1">MSARSAALSGRKELLQWLNKLCDADYPAVESLRDGAAYCTIVEAAVNRVAQNCAATQSSEAPVTKSCADRAHVYLGKLDWSATAAVCENADPSRDSVSVREVCFHNMRLLQDMLQECVPAEHRNTVDANRLATGKLQDHVVLLRWLYLFMSKVLAHYSKKALEKKAGVVAGTVEGVKLNRTVRLRSRQASSSDHRGARGLAQPYENKNDLMREENSTTPRWLHAARSPSGTSSRERAHRDRGDSARDSNSPFRTPTGSNGGPAPAHTSSRGGLPDAGITTSSTSARATPATGPAKGYVSESAQEVLRERTVHAHYTRGTIAVPEVFRSTLVHLRDEVEELERQVLCAQERHNYHLTHRASEGETDRVLSVAAAKYDQDTSLGEEGRETLSLEELGELLEERDRLAQQYATVDAVVTRALQSARSQGKPIPPLLRDLVELLHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXV8</accession>
    <accession>E9BGF9</accession>
    <name>A0A3S7WXV8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_17875</name>
        <name evidence="11" type="ORF">CGC21_17000</name>
        <name evidence="10" type="ORF">LDBPK_231450</name>
        <name evidence="8" type="ORF">LdCL_230021600</name>
        <name evidence="9" type="ORF">LDHU3_23.1940</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861038.1">
        <property type="nucleotide sequence ID" value="XM_003860990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXV8"/>
    <dbReference type="SMR" id="A0A3S7WXV8"/>
    <dbReference type="GeneID" id="13390238"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1940"/>
    <dbReference type="OMA" id="RRHYWAR"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5430277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP51283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="320" mass="35235" checksum="16123EFD67A3E752" modified="2019-05-08" version="1">MRPAGTIASFMERCSARKPGRGCVVLTGAGCSTESGIPDYRGPNGQYHRADFVLLTFQNFMRDDNEKRRYWARSMLGYSTISGASCNAAHMALQAFTKSGAVAHILTQNVDGLHHLATYGGVGDAEEEHYYKYTTSNAPLKELHGNIHNVICTSCGFLMPRARLQRELRERNPALYEQYGADMSRVRPDGDYSAPTEALNAMHLVMCPRCNGFFKPHVVLFGENVPKPIVETTMNVVRDKASCLLCLGTSLQVYSAYRYVLEAKQLGIPVAIVNAGMTRGDAIADLKLNVESVGSVLAETAHEMLGVPASMFFRRKTIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXZ3</accession>
    <accession>E9BGL5</accession>
    <name>A0A3S7WXZ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_11490</name>
        <name evidence="7" type="ORF">CGC21_15700</name>
        <name evidence="5" type="ORF">LDBPK_240030</name>
        <name evidence="3" type="ORF">LdCL_240005200</name>
        <name evidence="4" type="ORF">LDHU3_24.0050</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861093.1">
        <property type="nucleotide sequence ID" value="XM_003861045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXZ3"/>
    <dbReference type="GeneID" id="13390543"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0050"/>
    <dbReference type="OMA" id="NFFMIRK"/>
    <dbReference type="OrthoDB" id="263864at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600663" evidence="2">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="166" mass="18233" checksum="83CACE964F1B6CA5" modified="2019-05-08" version="1">MRVLCLRPLAALPAGLAARFYGGEGGARTPAGGRYPRGGGPPHPDRRNVPTEPQIVARLITFFPRINTFVPISRWAAALPDDLREALVPYGGLGAFASAQSNFFMIRKENGVTVASLSAMGAELAMEHERKEKQEQKRVEKLNQRRENFAQRGRSFPPSRGGPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY02</accession>
    <accession>E9BGL6</accession>
    <name>A0A3S7WY02_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L17, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L22</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosomal_protein_L22p/L17e_putative/Pfam:PF00237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_11495</name>
        <name evidence="9" type="ORF">CGC21_15705</name>
        <name evidence="7" type="ORF">LDBPK_240040</name>
        <name evidence="5" type="ORF">LdCL_240005300</name>
        <name evidence="6" type="ORF">LDHU3_24.0060</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 2-155</scope>
    </reference>
    <reference evidence="5 11" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="10">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="11">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861094.1">
        <property type="nucleotide sequence ID" value="XM_003861046.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="T=1-166"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="P=1-166"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="T=2-155"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY02"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3S7WY02"/>
    <dbReference type="GeneID" id="13390544"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0060"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="274658at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5430335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP52146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="166" mass="19113" checksum="2D29FCBCEB1ABC9D" modified="2019-05-08" version="1">MTHYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQVLAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEANAIEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMSEKKERVPTPKSAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY79</accession>
    <name>A0A3S7WY79_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_240014200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY79"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1090"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF3">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1192" mass="119607" checksum="AE8B057914676AB8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZD2</accession>
    <name>A0A3S7WZD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PCI domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250028900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZD2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2790"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000036">
        <property type="entry name" value="PCI_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="338"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="437" mass="49154" checksum="D35EFA5097B9C473" modified="2019-05-08" version="1">MEDDYYYDDDGDYGDYYDNDTDEVVDVSPLELKYVDGKSFMQSNVEESLRCLQEVVAEDSEHGRWTFKALKMLARACRIAKLYDAMADYYTQVVHFIHPDIGAAAVAKAMLKFTEESLRVPAEWRGRTLRATLEVATAQPESYRNVIVPTLLHRATLFLEEDKCEESLVDLQAALQQCDESIVTMAQINANCVYHIRTLQLTAYRKLNRYAELRRAYYELGRVHAALPSLRMIGSAMESAGHLFLHDADWAAAHRAFSSALRCHTESGDAQQYNVVKYVVLAAIMAGLPVDVFAQEETLANHPSVRPVRALWQAFVALDVSTFLQVLHAPDNAACFAKDAEFAAYVEPMMFQLRTNYLIAYSKSFGTLSLLELGARLQLQEQPCKELCTSAILLGLINARIDDARKLLLFQRASRAVPSSVAVLRDLSDLTSELCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X011</accession>
    <accession>E9BIL0</accession>
    <name>A0A3S7X011_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_5445</name>
        <name evidence="6" type="ORF">CGC21_32295</name>
        <name evidence="5" type="ORF">LDBPK_261990</name>
        <name evidence="3" type="ORF">LdCL_260025500</name>
        <name evidence="4" type="ORF">LDHU3_26.2620</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP52072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861784.1">
        <property type="nucleotide sequence ID" value="XM_003861736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X011"/>
    <dbReference type="GeneID" id="13389031"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2620"/>
    <dbReference type="OMA" id="HSGAQDD"/>
    <dbReference type="OrthoDB" id="268046at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056614">
        <property type="entry name" value="FAZ1_cons"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23398">
        <property type="entry name" value="FAZ1_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellar attachment zone protein 1 conserved" evidence="2">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP41228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="226" mass="25524" checksum="9D787B17806E2A71" modified="2019-05-08" version="1">MPASVHSDDSESRKKTARNSDGDSGDRIIDGLRYPRPGRQIDQFGFELTTHSLHFHGCDWDIPLTQKRDELTKAFMQDAAEATNEPEENIRNLRFIVTPTHLDAKFTVRHKVHVSKDKVHKMLSSSKWTLVKALYEPRQKMRRPNKPAKARAGHRGAQDDQPMLGSNRRTPSHNLSFFGRANVGAEGPEFEDHADDGEEPVAYEHQLDAKMRRTTSGLFISVGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X080</accession>
    <name>A0A3S7X080_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_260030300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X080"/>
    <dbReference type="SMR" id="A0A3S7X080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260030300"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11923" checksum="AC6F1F52EC0E8F87" modified="2019-05-08" version="1">MRTVPQSDLFASLDPIGALRDTTPRLLQVLQQEVRDAVAAAVRESAYDTTTSRAARALAEVQLFQIDRLVAEPTRKELVHCSLPLLRAEVARLEAALAETARAAPPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X189</accession>
    <name>A0A3S7X189_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar efflux transporter for intercellular exchange, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_280008400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X189"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0450"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000056">
        <property type="entry name" value="Sugar transporter SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26081" checksum="2D3B2101043F44B0" modified="2019-05-08" version="1">MTAFNIVYNLLTYTAGGFSVIMNASPVIAIRRLEQSGTVGASTVTFYGAQMYNAVTWTSYGIFSASYPLLIANILGNAVSTYCSLVFLTVARREEMSGLTLQATTYSKSVLTYAFFFVLSAAHLLLSIVLTMSGRPETAKTITGYEGSVACIVMLSAPLLAFKHIVVTKNAEVLAPVMVGCAFFNTLFWLVAGLMTNDMFITVPNFLCFLACCAQVVLLVMYGRRPAAPTEINEAIAPTPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2X4</accession>
    <name>A0A3S7X2X4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_290031300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2X4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3760"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF58">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="212"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU80747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="415" mass="46906" checksum="3E9666F1FF336833" modified="2019-05-08" version="1">MAQYKPIKSTGVATPYLVHGAAEQYLRIPCAAFLWYAFLSGALAPFLRTADEATVASCHFIVWRVLRWVHAYLCANGVFIVTLFLVENIRCLIAPGPRQLSLADDYEEGNPTKVDKMAAFEYDTPADAYERVKMFCFMITGVAFVRIFTATTGIFLGLFTASVAGYLDRYAHPWWFGFWSRLTAFISIVAFSVLGVYNVQQYGQFATRSECKILIANHSCVIEVIWVYVMGGFPSFVSRKENLSFFFFGNVVRGSSSILVDRDAATSREQAMTTILRRAGDPTAPQLMIFPEGTTGNQQALFMFKKGVFEAAVPVQMVCIAFPYKHFNPAWTGRGVGGNGLWDILVRLSCQFVNYAEVRLLPVYHPTEEERRDPKLYASHCQRMMATVLRENISDASFSDYKEAFRHFTELKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X438</accession>
    <name>A0A3S7X438_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_310009500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X438"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310009500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0550"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="406"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="939" mass="101232" checksum="61B6F6A10B933C37" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4B8</accession>
    <accession>E9BMN9</accession>
    <name>A0A3S7X4B8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Monoglyceride lipase, putative</fullName>
            <ecNumber evidence="2">3.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_11675</name>
        <name evidence="3" type="ORF">LDBPK_311150</name>
        <name evidence="2" type="ORF">LdCL_310018200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863206.1">
        <property type="nucleotide sequence ID" value="XM_003863158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4B8"/>
    <dbReference type="SMR" id="A0A3S7X4B8"/>
    <dbReference type="ESTHER" id="leiin-a4i6n9">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="GeneID" id="13385925"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1900"/>
    <dbReference type="OMA" id="QNAQNLW"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000117">
        <property type="entry name" value="Monoglyceride lipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="56"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="311" mass="34654" checksum="6F543B57447F4C32" modified="2019-05-08" version="1">MPCCCSGGHCLKYATPGRAPPDPQLFPHYMQNAQNLWLHFSEWWPHGDGGSCPAPPTKGVVFIVPGLGEHTGRYDSVALRLNQEGYVVFSMDNQGTGGSEGERLYVERFTHFVDDVCAFVVFIQTRYAALKSQPTFLMGHSMGGLIATLVAQRDASGFRGVVLSGPALGLSKPVPRFMRSLAHFLSQWFPKLPVRKLNPELVSYNTPVVQLVKQDPFYSNVTLRARFVDEMLIAQDRAAEAAATSKFPFLIVHGEEDQLCSLETSKSFFKNALSEDKFLASYRRAGHEVLTELCRAEVMAEVMKFINERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4D1</accession>
    <name>A0A3S7X4D1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emp24/gp25L/p24 family/GOLD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_310018000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4D1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1850"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="146"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36556" checksum="F72A85C0A15D1A23" modified="2019-05-08" version="1">MTRRSDLSCGLQGRQCRCHCSSASDIRCCCPLVVSFFFALPWPLHICASLSAPAERRLLRVRVISAGTSLRCIYMSVRQTGDSTSPTHLSPGLWRPFFEVLSIPPPPPTHTHTNQKMKRRGALLSVSVLVLLVGALVATAAAPASAIAVGVEATEVFSVTDIVPPGNNLVFAFYMNPDFVFPVRIRCRETGDVLQAWKDSPQGYLNLPSTDKTRHLVFEFDNSQSLLALSSVSFEIRVIPDPTRGVREEEIDPIEKKVQTLFEKMQTLRKLQELIRYNQKDHRALVEHANERVHWWSIMQVVSFFVAAGGQLWLLRSFVEKRRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4X4</accession>
    <name>A0A3S7X4X4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein</fullName>
            <ecNumber evidence="6">1.2.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_310035100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.4.2" evidence="6"/>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4X4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310035100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4790"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF222">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="134"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="4">
        <location>
            <begin position="492"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="626" mass="67565" checksum="EE47E488AADB3A7C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5P9</accession>
    <name>A0A3S7X5P9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_320029000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2940"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1654" mass="183767" checksum="6FE27DDC3E2E9C7D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5Y7</accession>
    <name>A0A3S7X5Y7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prefoldin subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_320035800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5Y7"/>
    <dbReference type="SMR" id="A0A3S7X5Y7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320035800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3760"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000024">
        <property type="entry name" value="Prefoldin_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="570" mass="59490" checksum="677C8A3BBF03B99B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X736</accession>
    <accession>E9BPN2</accession>
    <name>A0A3S7X736_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_37190</name>
        <name evidence="3" type="ORF">LDBPK_332940</name>
        <name evidence="1" type="ORF">LdCL_330036500</name>
        <name evidence="2" type="ORF">LDHU3_33.4090</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864118.1">
        <property type="nucleotide sequence ID" value="XM_003864070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X736"/>
    <dbReference type="SMR" id="A0A3S7X736"/>
    <dbReference type="GeneID" id="13392514"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330036500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4090"/>
    <dbReference type="OMA" id="FFDECHY"/>
    <dbReference type="OrthoDB" id="269730at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40736:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5433501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="151" mass="17099" checksum="84E232AEA095BA06" modified="2019-05-08" version="1">MSTAQAAIVKRSSSALQRLVVDPLMNVAHKIEGHSAKKMQSMEPAMAEWIKAQEATGSDAATISRQRFLREQHQLMSYRVVRFFEECRYIASGQYYKNYSIGCFLQDARFATQAFFIFLMAVMAGRRSVYPPISPNSPLAIALDHKVNPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8B8</accession>
    <name>A0A3S7X8B8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340040100</name>
        <name evidence="3" type="ORF">LDHU3_34.5290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8B8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5290"/>
    <dbReference type="OrthoDB" id="264200at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="727" mass="77293" checksum="2CF6C8FF4DC95759" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8I9</accession>
    <name>A0A3S7X8I9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L13-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">50S_ribosomal_protein_L13-like_protein/GeneDB:Lmj F.34.3680</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L13 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_20760</name>
        <name evidence="4" type="ORF">LdCL_340044100</name>
        <name evidence="5" type="ORF">LDHU3_34.5710</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8I9"/>
    <dbReference type="SMR" id="A0A3S7X8I9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340044100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5710"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000010">
        <property type="entry name" value="50S ribosomal protein L13-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5433945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="202" mass="24075" checksum="3443013097E566F1" modified="2019-05-08" version="1">MLRATFILGAPFKSVLRRHKYHPEGLPLYNDLSKQWLCREGERWWLLDARGQQLPHVAKIAAQYMTGQHRPDFTPGMMTGDHVVITNIKDAVMTGDNWIRVPITWQTAYPGGKYRVRLSEMYERDPCMVMWWYLKDEVNRHFVRKLKTRTAPLEKAWLYEDSVHPHAEKNPRPLVWTDTATMGWRYKDPTFQRRWSPNQFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9I5</accession>
    <name>A0A3S7X9I5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPR repeat/Pentatricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PPR_repeat/Pentatricopeptide_repeat_domain_contai ning_protein_putative/Pfam:PF01535/Pfam:PF13812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_350034900</name>
        <name evidence="5" type="ORF">LDHU3_35.3870</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9I5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3870"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="779"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="916"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117931" checksum="0AAC3046C40A57F0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAG3</accession>
    <name>A0A3S7XAG3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoplasmin-like protein (NLP), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360016300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAG3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1460"/>
    <dbReference type="OrthoDB" id="273390at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053271">
        <property type="entry name" value="DDT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15546">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN, 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15546:SF2">
        <property type="entry name" value="DDT DOMAIN-CONTAINING PROTEIN DDB_G0282237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="5">
        <location>
            <begin position="485"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="751"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="704"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111659" checksum="AF4DBA8EB0E1D7E1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XCB1</accession>
    <accession>E9BV42</accession>
    <name>A0A3S7XCB1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_38655</name>
        <name evidence="14" type="ORF">LDBPK_366860</name>
        <name evidence="13" type="ORF">LdCL_360081100</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865797.1">
        <property type="nucleotide sequence ID" value="XM_003865749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XCB1"/>
    <dbReference type="SMR" id="A0A3S7XCB1"/>
    <dbReference type="GeneID" id="13386651"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360081100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9140"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000235">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ39121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP53347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="259" mass="28550" checksum="E102DB8EB3BCB542" modified="2019-05-08" version="1">MAWHCSSTTNAGMVAALQREGLIKTPEVIEVMRRVDRGWFVRNPKDAYRDQPLPIGFGVTISAPHMHAIMLELVSPSVLRHKNLNRGHSQPLRLLDIGSGSGYMTAAFAALCEAAWRDGEPPMFEVVGIEHVQELQKQSMRVLESHFPEWIRGRRVTLLHGDGRKPRSIAGVGEEKGECFDVIHVGATAPKSLVPEYLSLLRCGGTLVIPVGSPAEVQELQVFTKGDEGAFTMRRACHVQFVPLTSLHAQLDGDVTTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJD9</accession>
    <name>A0A451EJD9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglycan beta 1,3 galactosyltransferase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_020005000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJD9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5600"/>
    <dbReference type="OrthoDB" id="263275at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="815" mass="90873" checksum="8AB7BD5E0A54AD24" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJE0</accession>
    <accession>E9BI11</accession>
    <name>A0A451EJE0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CGC20_26065</name>
        <name evidence="18" type="ORF">CGC20_37320</name>
        <name evidence="17" type="ORF">CGC21_29785</name>
        <name evidence="20" type="ORF">CGC21_33735</name>
        <name evidence="16" type="ORF">CGC21_9250</name>
        <name evidence="15" type="ORF">LDBPK_210020</name>
        <name evidence="11" type="ORF">LdCL_020005100</name>
        <name evidence="12" type="ORF">LdCL_250031500</name>
        <name evidence="13" type="ORF">LDHU3_02.0030</name>
        <name evidence="14" type="ORF">LDHU3_25.3070</name>
    </gene>
    <organism evidence="11 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 21" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 22" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 22">LdCL</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812622">
        <property type="protein sequence ID" value="CAC5426961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000040">
        <property type="protein sequence ID" value="TPP43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000062">
        <property type="protein sequence ID" value="TPP44012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861587.1">
        <property type="nucleotide sequence ID" value="XM_003861539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJE0"/>
    <dbReference type="GeneID" id="13388832"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020005100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250031500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.3070"/>
    <dbReference type="OMA" id="XRISAMI"/>
    <dbReference type="OrthoDB" id="257350at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000058">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU75601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5426961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5430834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP40852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP44012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP48794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP49239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="100" mass="11452" checksum="25E15FF880C3945E" modified="2019-05-08" version="1">MAKGKRSTDAKGSQRRQKKVLRDNIRGITRGCVRRMARRGGVKRISSEVYEEVRRVLKAYVEDIVRCSTAYTEYARKKTVTACDVVNALRKQGHILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9B813</accession>
    <accession>A0A3S7WNR7</accession>
    <name>E9B813_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_040480</name>
        <name evidence="2" type="ORF">LdCL_040010300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858110.1">
        <property type="nucleotide sequence ID" value="XM_003858062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B813"/>
    <dbReference type="GeneID" id="13390721"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0640"/>
    <dbReference type="OMA" id="EYVFGME"/>
    <dbReference type="OrthoDB" id="246814at2759"/>
    <dbReference type="PhylomeDB" id="E9B813"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34545" checksum="2C02C6CD4B11C464" modified="2011-04-05" version="1">MAKSSRSKWKKMHRRQRAQAEATNTVKRIRLLNKKLELTVKGGISAVPPQEPEKRFHFLNPVLDSRVPNTRKNLNNNYRAELNHVQYDYTKPLKLAPPKTNMYGKTDVDAPHPMTVMYETIDADAPLAGHALTKADMERLARRQAQQEREASAAVADAEEDAGEEDGDNDSGDNADDGPEEYVFGMEDAAPRRTRGQQKTSAKKKGSVAPKALKGAASASAGASSSVSVAGSSSRMLAAAAAAMANEEEEADHHPRHGGVTAVNKIASMQAMRKKNGAMVSAGGASKMKKVGKLGGSSGTRVVSSGGKVARKDVGNAKNSTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9B943</accession>
    <accession>A0A3S5H5X2</accession>
    <name>E9B943_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine Rich repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_070480</name>
        <name evidence="2" type="ORF">LdCL_070008300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858489.1">
        <property type="nucleotide sequence ID" value="XM_003858441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B943"/>
    <dbReference type="GeneID" id="13391867"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0400"/>
    <dbReference type="OMA" id="VYARCCE"/>
    <dbReference type="OrthoDB" id="273039at2759"/>
    <dbReference type="PhylomeDB" id="E9B943"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001047">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF22">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="112038" checksum="DE22F407765B64F7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAL7</accession>
    <accession>A0A3S7WRI4</accession>
    <name>E9BAL7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_110290</name>
        <name evidence="2" type="ORF">LdCL_110007800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859006.1">
        <property type="nucleotide sequence ID" value="XM_003858958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAL7"/>
    <dbReference type="GeneID" id="13389824"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0350"/>
    <dbReference type="OMA" id="TAPCGRE"/>
    <dbReference type="OrthoDB" id="266941at2759"/>
    <dbReference type="PhylomeDB" id="E9BAL7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="463" mass="49847" checksum="1EC52254A0B4371A" modified="2011-04-05" version="1">MLRQCERLIVQLSQQVLEQEKDIRSLRAALHSSPHRQRRHRQRGGDEKRERAAAVSTAESFSVSAEGRRHHHAHHITAKVPTQRKMTHEDSRLCLTLPSPTTPQVSPINSSEDAGVNSTTGPYPEATVVAPHSPQSSGAGSAVPSPTRSASKSSGQHGMAAALAFPSIVCDVSSFSDKANVGLTPSTVCDRPPSGEAATADALWASSLLSEQERSSSSSSLARHPRNTAQRTRNAQFETPRVKFDNQDAMSYLLSVFSSVKSTREADGGATAAMAEVGETAPCGREHRGGAGVRSPNAPLQRQGEHVARRLFRLDPVDEDEGSESGNEHSSGGAVSDYDRPAARRPFLPPSRDKRCDGDGSAPPNHKTCGSFDEDDAFLQERYARIVACALAAEFTAFTTLVGEDEVQQQRGCKTGPRTPTAARCRTTSRRDHSTSATVSELLQLFTFQPATRHQPDSDGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD19</accession>
    <accession>A0A3S7WU65</accession>
    <name>E9BD19_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinesin, putative</fullName>
            <ecNumber evidence="10">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_161680</name>
        <name evidence="10" type="ORF">LdCL_160021800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="10"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859852.1">
        <property type="nucleotide sequence ID" value="XM_003859804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD19"/>
    <dbReference type="GeneID" id="13393225"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.2000"/>
    <dbReference type="OMA" id="YMDMGAS"/>
    <dbReference type="OrthoDB" id="264170at2759"/>
    <dbReference type="PhylomeDB" id="E9BD19"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000751">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000132">
        <property type="entry name" value="Kinesin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="11"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1082" mass="119495" checksum="95C0312FDA1B5BE5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDX2</accession>
    <accession>A0A3S7WV33</accession>
    <name>E9BDX2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone DNAJ protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_181410</name>
        <name evidence="3" type="ORF">LdCL_180019500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860155.1">
        <property type="nucleotide sequence ID" value="XM_003860107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDX2"/>
    <dbReference type="GeneID" id="13385980"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1800"/>
    <dbReference type="OMA" id="STRNTHT"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="PhylomeDB" id="E9BDX2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052812">
        <property type="entry name" value="Plant_DnaJ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44272:SF3">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1121" mass="121855" checksum="CE102DEAC9F509A1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFM9</accession>
    <accession>A0A3Q8ILE0</accession>
    <name>E9BFM9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_220100</name>
        <name evidence="8" type="ORF">LdCL_220007100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860760.1">
        <property type="nucleotide sequence ID" value="XM_003860712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFM9"/>
    <dbReference type="SMR" id="E9BFM9"/>
    <dbReference type="GeneID" id="13389325"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0370"/>
    <dbReference type="OMA" id="KARMQNV"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="PhylomeDB" id="E9BFM9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF301">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="89"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="485" mass="53971" checksum="766F7DA1E73B4C09" modified="2011-04-05" version="1">MSHNPDYTVMQDGGRQRYKEETQSSTPASGDNRAAAEIDATICKEEKEMHETFDQVHELVTECNAEVEVPKQQPMFLVRLMRRVIPPGGFASGVFNLAGSSLGAGILGLPYAFDTSGIVMGTIYLIVIYLLTVYSVRLLAIVYGKTGIRSYELTARILFGRGGDIFTAVIMFIKCMGACIAYVICINDLWHAFLNDDRVQGYYRSVSFQRVLTSVTFLLLMLPLSLPRQINSLRYVSLFGVVFVLYFVVCVVIHSATHGLKEGITSKGLRLFNTGNRAIQGLGQFVFAFLCQSNAYQVFNETPKPSVRFFELQVLVSMLICTVFYWVTGFFGYCDFGDKVGSSLLRMYRPLTDYYFAVAYVGLVVKLCVAFALHILPSRDSVHHLIGWDLHTVAWWKNAVLCTFLSLVSLLCGLFIPNVNTVFGLLGSFTGGFIAFVFPALFFIYSGGYELKKVGYYNYFGAIVLLICGVTIICFGTTATIYGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BH82</accession>
    <accession>A0A3S7WYS5</accession>
    <name>E9BH82_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl-CoA synthase, putative</fullName>
            <ecNumber evidence="3">2.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_242200</name>
        <name evidence="3" type="ORF">LdCL_240027600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.3.10" evidence="3"/>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861309.1">
        <property type="nucleotide sequence ID" value="XM_003861261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BH82"/>
    <dbReference type="GeneID" id="13391469"/>
    <dbReference type="KEGG" id="ldo:LDBPK_242200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240027600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2680"/>
    <dbReference type="OMA" id="HFMNLEE"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="PhylomeDB" id="E9BH82"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000086">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-CoA synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="501" mass="55377" checksum="3C44FD6D5015C4BA" modified="2011-04-05" version="1">MMRNTCLNLAGVSGMAVYAPHCRVDLEQWCKWTGNSWDKVSSVVGQSFRITNYNENAYTMAANAVLRLIVNNNIDPTKIGFLGLGTESSSDNSAGAIIVKGMVDKGLRAMNMPAMSRHCEVPEFKHACLAGVYAMESATRFVDADGKDRMAIAVASDIAEYALGSTGEQTQGAGATAMVLEHDPKLFEVQLQHSGSASDYRGPDFRKPHRRHFMNLEEYTKSSANGKMADFPVFSGPYSTLVYQEEVTVAVEHMLERLQQSPGKYYDDVTALFFHRPYNMMPIQAMSFLYARGLARATSEEHKAYFAELCKQGKADPAAVLKELDVNPHYFQQIESGGEPKDAFPATGKVAKVLRKDKKFIDLLEKKMSMGSPAMGNFGNLYTASLPCWLAAGFEEAYTRKLDITGKPMVMVGYGSGDASMSIPILPVPGWENAAANINVSKALENPVNLDKAQYEALHTGAEKNDLAKDRRKMEFVIDRLGNRNEAAFQDVGIEYYRYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHD8</accession>
    <accession>A0A3S7WYR3</accession>
    <name>E9BHD8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_250340</name>
        <name evidence="3" type="ORF">LdCL_250008500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861365.1">
        <property type="nucleotide sequence ID" value="XM_003861317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHD8"/>
    <dbReference type="GeneID" id="13388611"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0410"/>
    <dbReference type="OMA" id="FAFRWES"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="PhylomeDB" id="E9BHD8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="71929" checksum="DDDB77587A677580" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIW7</accession>
    <accession>A0A3S7X0E2</accession>
    <name>E9BIW7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_270330</name>
        <name evidence="2" type="ORF">LdCL_270008100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861890.1">
        <property type="nucleotide sequence ID" value="XM_003861842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIW7"/>
    <dbReference type="GeneID" id="13389151"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0400"/>
    <dbReference type="OMA" id="RGGHPRN"/>
    <dbReference type="OrthoDB" id="271584at2759"/>
    <dbReference type="PhylomeDB" id="E9BIW7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="494" mass="54854" checksum="E3BDB9550E47F442" modified="2011-04-05" version="1">MRRCIRLVYARSSGAMTGAAPPPAVLEASASSSVGLYQKCLNPMTSAGDVASLTAALLPAIGRGELSLHQQVQLLHALAARSIRYEDVMLRCLWTVFKAPSPTDDDVSVESSKARGCYSLSELSAYTSSAFQVMAEQRFLNDPQMTAVALGRCVELIPYASLDGLRSTYRGLSAVNHMFFSVAEVAHHSSEVTERMTTKEFYQTTDVPDEETLRHQPNLIDVLCGEVELQLRRLCDTFARAAPGPFEVEDDLPAPVATGALLTPSDARDTHEAQWFLDVLEALAVVGVLHAGTLDSLTDLVSRYCTQSSAGFFIKALAHATLIEERVVDPLTYEESAAVRDARRRLTLHLSGKILQARGIHGYLRRHPQELLLLRRLFEHDTAQPTLSPDLWDAVRTIHVAHRHTVAASQTSRRPVGALFQKMYDVKVKPISVDNAEPERFVPPEFKTWRSPAATPRGGHPRNRRPSRRMAFGTRRISKNYIKNKRRKFCPAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BK65</accession>
    <accession>A0A3S7X171</accession>
    <name>E9BK65_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_280250</name>
        <name evidence="12" type="ORF">LDBPK_280260</name>
        <name evidence="10" type="ORF">LdCL_280009900</name>
        <name evidence="11" type="ORF">LDHU3_28.0630</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862126.1">
        <property type="nucleotide sequence ID" value="XM_003862078.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024329244.1">
        <property type="nucleotide sequence ID" value="XM_024473473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BK65"/>
    <dbReference type="SMR" id="E9BK65"/>
    <dbReference type="GeneID" id="13386862"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280250"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0630"/>
    <dbReference type="OMA" id="ENTSYMF"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="275"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5431432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="522" mass="57005" checksum="9AA52F874DD3A7B7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BN21</accession>
    <accession>A0A3S5H7Q5</accession>
    <name>E9BN21_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_312510</name>
        <name evidence="2" type="ORF">LdCL_310033100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863338.1">
        <property type="nucleotide sequence ID" value="XM_003863290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BN21"/>
    <dbReference type="GeneID" id="13389670"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310033100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4520"/>
    <dbReference type="OMA" id="QKVEMWP"/>
    <dbReference type="OrthoDB" id="262737at2759"/>
    <dbReference type="PhylomeDB" id="E9BN21"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26223" checksum="FED64BF55C0D9C28" modified="2011-04-05" version="1">MAAETKPPLQQQQQQQPNDTHPPQIAVRKQGTYERGRWSTRILTIDVDAGMVTISRKSKPQDVLYRSLHVQKVEMWPRYSPYAIEGSYDSLKAKMVLCITGTEVTLTNHGSSVGNFLRSNIGSLISASIAAENSAWSAKPSKRVGLKEVFSKRNPMFATIPSNSAATDSSTITWLIQFTSIESYELAVMLFMRFKNEGGSRRKVFSNNVAADLACVKEAWVNHAARFKTATDTDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNY5</accession>
    <accession>A0A3S5H7S3</accession>
    <name>E9BNY5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_322340</name>
        <name evidence="2" type="ORF">LdCL_320028700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863647.1">
        <property type="nucleotide sequence ID" value="XM_003863599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNY5"/>
    <dbReference type="GeneID" id="13390935"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2910"/>
    <dbReference type="OMA" id="PPYEWAP"/>
    <dbReference type="OrthoDB" id="266643at2759"/>
    <dbReference type="PhylomeDB" id="E9BNY5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="639" mass="67824" checksum="C1D07693D2753656" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPX2</accession>
    <accession>A0A3Q8ITU6</accession>
    <name>E9BPX2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaic translocase of outer membrane 11 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_330430</name>
        <name evidence="2" type="ORF">LdCL_330009800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863867.1">
        <property type="nucleotide sequence ID" value="XM_003863819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPX2"/>
    <dbReference type="GeneID" id="13392264"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0680"/>
    <dbReference type="OMA" id="ISKVDWW"/>
    <dbReference type="OrthoDB" id="248858at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10662" checksum="3FD6BA71592A9BBB" modified="2011-04-05" version="1">MMFGRAHAPQKEWGSMYFYEKLHHLIDHTSNFVISKVDWWLPSVAVGIALSLFVLGGPEALPQAASIVLPSATPAVTTPPFATPDGPQGGAAPEDDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ77</accession>
    <accession>A0A3S7X6S8</accession>
    <name>E9BQ77_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_331460</name>
        <name evidence="2" type="ORF">LdCL_330021200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863972.1">
        <property type="nucleotide sequence ID" value="XM_003863924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ77"/>
    <dbReference type="GeneID" id="13392367"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2190"/>
    <dbReference type="OMA" id="TPGQHYA"/>
    <dbReference type="OrthoDB" id="267363at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ77"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="424" mass="44734" checksum="0F6E195960E575BC" modified="2011-04-05" version="1">MSIIYVDELAIRLPSDVRNTFNPLCAFGSSSNSGANPHNNNRCSAPVMGLREVQSGHVLLPIDAEGSIVVTPGQRYTVVLVRETRGGTVASAAAPPARAELSAASNGHQNSADSNTDKKIKSAAPAKPHQPHQQQQPVKKPGLPREASAAEPLAQPAMPPAQKANLSKKERKAARESAAEEHVYGGAAPSVSTVAQTEQPSKKRKRQDDGAAQAAQQQHRQKSSPTLNARVESADTDDAPLMAAYRSSQSHTSSRTSPVMEPSTSAESSRHNSKRGSLRSKTETVVAPPPPTRRSLSSIDGYDDEEGAQPLAQLYSAQSAASQPPVPEPKHAGEEETRITATSKKRRSPSEKTTKPTSASTAAPTAAPRVPSPPQPATCTAAEPATKTLRQKSASPDRVPVTLPPSSRTSTVRRVPLDTSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUA6</accession>
    <accession>A0A3S7XBB6</accession>
    <name>E9BUA6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_363980</name>
        <name evidence="5" type="ORF">LdCL_360046800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865512.1">
        <property type="nucleotide sequence ID" value="XM_003865464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUA6"/>
    <dbReference type="GeneID" id="13388398"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360046800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5330"/>
    <dbReference type="OMA" id="REYHESQ"/>
    <dbReference type="OrthoDB" id="264536at2759"/>
    <dbReference type="PhylomeDB" id="E9BUA6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42180:SF4">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42180">
        <property type="entry name" value="HOMOLOGY DOMAIN-CONTAINING PROTEIN,PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730296" description="Calponin-homology (CH) domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="921"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="967" mass="103973" checksum="7DB206FE9C419FFB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9U9</accession>
    <accession>E9BBV9</accession>
    <name>A0A3Q8I9U9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_4780</name>
        <name evidence="14" type="ORF">LDBPK_140750</name>
        <name evidence="13" type="ORF">LdCL_140012900</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859444.1">
        <property type="nucleotide sequence ID" value="XM_003859396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9U9"/>
    <dbReference type="GeneID" id="13391111"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140012900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0980"/>
    <dbReference type="OMA" id="CWHAHVS"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU77321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ32734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="326" mass="36745" checksum="DD6FB006A8EC0FC4" modified="2019-04-10" version="1">MESAAPSSTVTATSLTASSPSLSNPFLWAHHYITSFKGGKAHQWMCASPHIPLLIVVGYFLLVHAGPRVFSRLLGGKPVPGLAPIVAIWNLFFSIASTIGFCYCAPFLFRVLTMTNRELPGLAPKKDRTTGEWDQHPHVRGGLFTSLCYWNRNIFEDGATAFWVLTFNLSKIVELMDTVFLLLRHKPVPFIHWYHHASVMLFCWHAHVSGISNGLGFAVMNMLVHSIMYFYYFMCACGQRKLVRPFASMVTLLQIAQMFAGMALILYTTRLYVTHPGGCDTSASSLAFGTVMYLSYIILFVKLFRDNYVLKKRDGCERRRDTKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAB6</accession>
    <name>A0A3Q8IAB6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_150018200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAB6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1600"/>
    <dbReference type="OrthoDB" id="264043at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd23721">
        <property type="entry name" value="ZF_RNaseIII_KREPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="545" mass="59410" checksum="A630D45294F2FAFC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAN6</accession>
    <accession>E9BEU6</accession>
    <name>A0A3Q8IAN6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_29125</name>
        <name evidence="3" type="ORF">LDBPK_201470</name>
        <name evidence="2" type="ORF">LdCL_200019400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860488.1">
        <property type="nucleotide sequence ID" value="XM_003860440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAN6"/>
    <dbReference type="GeneID" id="13386267"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1840"/>
    <dbReference type="OMA" id="RFHYGVP"/>
    <dbReference type="OrthoDB" id="267094at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1223" mass="128600" checksum="3D121C1590FD579D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAX9</accession>
    <accession>E9BG76</accession>
    <name>A0A3Q8IAX9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SET_domain_containing_protein_putative/Pfam:PF008 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_230560</name>
        <name evidence="2" type="ORF">LdCL_230011100</name>
        <name evidence="3" type="ORF">LDHU3_23.0780</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860957.1">
        <property type="nucleotide sequence ID" value="XM_003860909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAX9"/>
    <dbReference type="GeneID" id="13389918"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0780"/>
    <dbReference type="OMA" id="HFQLTQA"/>
    <dbReference type="OrthoDB" id="270556at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="36"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="354" mass="39135" checksum="5E5E260D31579890" modified="2019-04-10" version="1">MPSYESRHMLRVLDSPEVLAKSFIGYCKRHRVTTRGWCRIGYVHRSPPQRTHSRPGNYLLRGLIANRDIAKDENVVMMPVTACLHPGAAFRCEPFWNLLAPEVQSALSSLTCAYNSRIADRSLIRHNQLLLALYMAYLVLLRNCNAARLSATPGGDAIEYINFMPRNEGNFEQFAAHLAGWLDAPEICRSAQASLASYFQLTQAEVRPVIIYALCMIYSRMVPVDHRACLQYALQSTPLARAWDDMEATAAPAALPPPSSSGSVGDGSVRSGVANASLVRDPISFLCPVIDMCNHSDHENVAVMVPDRETASVTGPVICLRTLRPIAKGEELTMTYGAAPHELKLIWGMQEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAZ4</accession>
    <name>A0A3Q8IAZ4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Aconitate hydratase</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="3 9">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_180010000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3 9"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAZ4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0630"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072350">
        <property type="term" value="P:tricarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="79"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="698"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="896" mass="97434" checksum="2A8D68A3A105DFCC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB76</accession>
    <name>A0A3Q8IB76_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RF-1 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_210021000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB76"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1840"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="453"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="126"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="583" mass="62344" checksum="88BEDD81A9BE7AD3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBI0</accession>
    <name>A0A3Q8IBI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200006900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBI0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200006900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0220"/>
    <dbReference type="OrthoDB" id="271766at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="200" mass="21946" checksum="EC448F53B10B78AC" modified="2019-04-10" version="1">MRRKRSSYVTCTVNGTACRSDDGMYDVKALYGPHTLLLRAPTTAPSSSFLSSAPSPAEASRRRSEPLTSFTICAVDARGRFVVKQSGTYEVGAIGAVEKQAEAEAEAEVQAAIHDVQRVPEAASKTAGERQSAMKEVRRAPNKYSMFLSKFSKVFSLKGFQAAAAEWRRFSAESKRREEVDALIATVVRSGRYPMRQPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBU6</accession>
    <accession>E9BGF5</accession>
    <name>A0A3Q8IBU6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_231410</name>
        <name evidence="3" type="ORF">LdCL_230021200</name>
        <name evidence="4" type="ORF">LDHU3_23.1890</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861034.1">
        <property type="nucleotide sequence ID" value="XM_003860986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBU6"/>
    <dbReference type="SMR" id="A0A3Q8IBU6"/>
    <dbReference type="GeneID" id="13390234"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1890"/>
    <dbReference type="OMA" id="RAFKTEH"/>
    <dbReference type="OrthoDB" id="240558at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="351" mass="39481" checksum="CD51A52E354A0742" modified="2019-04-10" version="1">MYPGEYVPAGHNTLSSLRDELRSDLTAQSLKEAWMRVSGGMYFKSIDDYYASVDGLDQEQLGEIVSALLPDLRKYEAQALVTKVLESLSKPADSPSRQLSRTITADAVGLDNAPGHYTNFLEWMGRMTETKAFKTEHALFEFSRRKFNREDVRVMFENYNLMSKATLEADSSDSYSHFYAVLHDFSRKVAGEDTRHQIGVRIDPAEVDPETGIAVGHGRADGQKYMFTALIRENRDHNGSVTLLGKPLSVAFDDKSWLMEMVLMPFDEAKLDFRDFDVNLISEGKAMPSFANEIAAFACRMAVANAITKLLPLARIPLKKAGLLSVDRRREPGQFPGFVDGKKNKRKFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBV0</accession>
    <name>A0A3Q8IBV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_8990</name>
        <name evidence="2" type="ORF">LdCL_250025300</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBV0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2420"/>
    <dbReference type="OrthoDB" id="10478922at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="245" mass="25457" checksum="B035051DCCBE5D81" modified="2019-04-10" version="1">MPCSFDTINTLFRPLSTSQHDGPSASTTAAVIELYMRLERLAIQSGSNSRPEIACDQGDNDGSATSVRASQRGSAVSCRLDGGRLRSTSSPQLFLLGDDGVVRELATALQVSSSSLLNSHDNTPPHGTGLAAALDGIIGDAQSRVYGTPDTPSSFLRRADEDSGTLAPSSSSHAAAPPPEVYTLSNSLRGLESMRAELCGWCSVVLLCYHVASPVSLALFGEEVAPSVLAALATAAHLTRPATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBY5</accession>
    <name>A0A3Q8IBY5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LEM3 (Ligand-effect modulator 3) family / CDC50 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_090017400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBY5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090017400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1300"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF73">
        <property type="entry name" value="LEM3 (LIGAND-EFFECT MODULATOR 3) FAMILY _ CDC50 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="595" mass="66616" checksum="606D70D7A923F7CE" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC72</accession>
    <name>A0A3Q8IC72_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoprenylcysteine alpha-carbonyl methylesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_150008600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC72"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0470"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="351"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="758" mass="83500" checksum="460F99A79829521F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC95</accession>
    <name>A0A3Q8IC95_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial chaperone, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_220014900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC95"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220014900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1220"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="324"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="722" mass="78966" checksum="3ACD2A74DD1A7EFD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICA0</accession>
    <accession>E9BAJ2</accession>
    <name>A0A3Q8ICA0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette protein subfamily H, member 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ATP-binding_cassette_protein_subfamily_H_member_1 _putative/GeneDB:LmjF.11.0040</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_30615</name>
        <name evidence="10" type="ORF">CGC21_1175</name>
        <name evidence="8" type="ORF">LDBPK_110040</name>
        <name evidence="6" type="ORF">LdCL_110005300</name>
        <name evidence="7" type="ORF">LDHU3_11.0050</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858982.1">
        <property type="nucleotide sequence ID" value="XM_003858934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICA0"/>
    <dbReference type="SMR" id="A0A3Q8ICA0"/>
    <dbReference type="GeneID" id="13389817"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0050"/>
    <dbReference type="OMA" id="DHHTAQG"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001871">
        <property type="entry name" value="ATP-binding cassette, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF688">
        <property type="entry name" value="ABC TRANSPORTER H FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP39794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="301" mass="33226" checksum="E7C96FD6D844A56E" modified="2019-04-10" version="1">MDPIISCDNIHKTYLLGVEGVPALRGVDVDINPGELLVVYGTSGGGKSTLLNVLGTIDTPTKGNMFLFGKRVTDQTPDSELAAMRCKRIGFVFQSFNLISTMDALGNVSLPMMIKGSLSASDIKKRATALLEEVGLGHRLHHFPSMLSGGEQQRVTIARALANEPEILFLDEPTGDLDTKNTLIIMNILMRLNREHGLTMVMVTHDVYMKQYAHRVIYIRDGKVSTTETVHSNVRERAWNELQKSLRKASTGTGEQKTPTSEQRTPQDYATFSAQGPLNLDEDPEMQQVVDVLFGPQQGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICN9</accession>
    <name>A0A3Q8ICN9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spliced leader RNA PSE-promoter transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260011300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICN9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0750"/>
    <dbReference type="OrthoDB" id="276008at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="703" mass="77781" checksum="C336194EB1B7FC16" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID02</accession>
    <accession>E9BK96</accession>
    <name>A0A3Q8ID02_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_280580</name>
        <name evidence="11" type="ORF">LdCL_280010500</name>
        <name evidence="12" type="ORF">LDHU3_28.0700</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862157.1">
        <property type="nucleotide sequence ID" value="XM_003862109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID02"/>
    <dbReference type="SMR" id="A0A3Q8ID02"/>
    <dbReference type="GeneID" id="13386893"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0700"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="134"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="313"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5431438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="376" mass="41144" checksum="F5AE1C7E04B0A258" modified="2019-04-10" version="1">MQTRSKAKGRRGRPSARPSEEVEVVESQPQEALQNEEQEPRQQQQQSTDMAEPNASGFRVIQILENYGVASSDIKKLMECGFYTVESAAYAPKKAILAVKGISENKAEKIMAECAKLVPMGFTSAVAYHEARKEIIMVTTGSREVDKLLGGGIETGSITELFGEFRTGKTQLCHTLCVTCQLPISQGGAEGMALYIDTEGTFRPERLVAVAERYKLDPEDVLANVACARAFNTDHQQQLLLQASAMMAENRFALIVVDSATALYRTDYSGRNELAARQMHLGKFLRSLHNLAEEYGVAVVVTNQVVANVDGSAQMFQADSKKPIGGHIMAHASTTRLSLRKGRGEQRIIKVYDSPCLAEAEAIFGIYDDGVGDARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID19</accession>
    <accession>E9BIK8</accession>
    <name>A0A3Q8ID19_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electon transport protein SCO1/SCO2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">SCO1/SenC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_32285</name>
        <name evidence="7" type="ORF">LDBPK_261970</name>
        <name evidence="6" type="ORF">LdCL_260025300</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861782.1">
        <property type="nucleotide sequence ID" value="XM_003861734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID19"/>
    <dbReference type="GeneID" id="13389029"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260025300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2590"/>
    <dbReference type="OMA" id="GKWLYIY"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF25">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="240"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP41226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="432" mass="48793" checksum="3A681D8918211006" modified="2019-04-10" version="1">MLTRRLITQRRLRKACRGGLDGLAGAPVASCSSLQWYSTGACARSPHNKGAGFPTTALRCVLSHYDACRAPIVTASPIRSSATFSCALSGSWRHASNTARSGGKDMDIVDQEKPIHIRVAEQRDSQIYTYSEYVEKHELEERAGRTISEAVDEMRDNPVWMLWALGFLTLGVVTVVISIRIRREQMRFDPKLRAVKSFDSPEGPSIGGPFSLVDVRTGKRVTDVDMKGKWLYIYFGFTNCPDVCPEEMAKMARVIKHLDKKVGKDYWQPIFISLDPKRDTPAKIREYLSDFSPRIMGLVGTQAEVEAAARQYRVYFAIPDEEAMSEDDYLVDHSIIMYLIDPEGRFSDYTTKEFQWFESYSKLLRRMMDYERHKATVEQQRAQRGEAPLADGEAPANLEIANLASMLDNAEAKAMEEEALHHQPKGLSSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID27</accession>
    <accession>E9BNM6</accession>
    <name>A0A3Q8ID27_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_20175</name>
        <name evidence="3" type="ORF">LDBPK_321230</name>
        <name evidence="2" type="ORF">LdCL_320018000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863539.1">
        <property type="nucleotide sequence ID" value="XM_003863491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID27"/>
    <dbReference type="GeneID" id="13390589"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1590"/>
    <dbReference type="OMA" id="WTEWVNW"/>
    <dbReference type="OrthoDB" id="248096at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="361" mass="39492" checksum="EA0BA4B9BAE38BD8" modified="2019-04-10" version="1">MSSSSAVIEGHAKDRWNFRIEDAGVPPTMVATSSWVFLSFIAAVLFLEVRPAAIRRARASAEHNACVIADDVNRSAHTRRLWRLLLAVWTCALYDVVHRTCSYCVLSAHMLARRRLLPLGRDFLWDGLWTEWVNWVRFYVLCAPSATTSAAAQLTSCADWKLPGAGALAYDQYPEYAALNVSSPATPSEVRLYHRVCLVSLAITWVAVVALHGQYALLRRLFCSAASSGATRSSKVVADEPARAREGQAMCAHDLTTALDAAEAPGDDSWVDSPEAIAEEARWRQQDEYLSLQRGSAHSVGMSADAPALPTSHLVWQCWPSLATAVYATLYAFVGGLPLLMILLFPAAIVIISVMAMLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDJ0</accession>
    <accession>E9BCL2</accession>
    <name>A0A3Q8IDJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_25315</name>
        <name evidence="3" type="ORF">LDBPK_160080</name>
        <name evidence="2" type="ORF">LdCL_160005700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859696.1">
        <property type="nucleotide sequence ID" value="XM_003859648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDJ0"/>
    <dbReference type="GeneID" id="13393064"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0080"/>
    <dbReference type="OMA" id="CRDSMGD"/>
    <dbReference type="OrthoDB" id="260743at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="399" mass="43466" checksum="D43E578F16E3BD86" modified="2019-04-10" version="1">MDAPAMAQETASSSPTEVRHTTSLNHTEWSALLRLLAEVQGRMEQRLEAVNVELEYLEAFRGGIVSEMRSESSPRRRSVTVPAPRDGGKRSREEVPFVGYAIASPRQRGEVGALGFDPFREAGLYMSSNNPVVRVAPLSLSRDEKARQEVAYILPSYISVGVARARGLPLAGAARLFESLTAAGLDQRDFALSSTSAGRCLSVHTPPDPGDVEALCAAVPEERVRALCRDSMGDAGAIASCLYTELAQQATLRALILPAMRLRSVKLLRLPPYRQQLLLEATTWTLQRCCDCRDRDLTENSHVQWCKVLHSAAPETESCAYLKRKAYATGYSQLLQGLSAVSSVRQGYLVAVLTVCGNFFDLLDAGKLPLQRRTSPFLFRGAHAAPNGDQTSLSPAVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IET9</accession>
    <accession>E9BJY6</accession>
    <name>A0A3Q8IET9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MRP protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">MRP_protein-like_protein/GeneDB:LmjF.28.2470</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">ParA/MinD ATPase like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_12845</name>
        <name evidence="12" type="ORF">CGC21_22745</name>
        <name evidence="10" type="ORF">LDBPK_282660</name>
        <name evidence="8" type="ORF">LdCL_280031700</name>
        <name evidence="9" type="ORF">LDHU3_28.3590</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862364.1">
        <property type="nucleotide sequence ID" value="XM_003862316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IET9"/>
    <dbReference type="SMR" id="A0A3Q8IET9"/>
    <dbReference type="GeneID" id="13387100"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280031700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3590"/>
    <dbReference type="OMA" id="CNHESHI"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5431648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP40384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP54390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="292" mass="31552" checksum="C3C30C318276A15D" modified="2019-04-10" version="1">MRFSRVSVPGIKRVITICSAKGGVGKSTTSVNVALALKNMGHSVGLVDADITGPSIPTMMGVESSQVETYRVAGSDRFGPPMNFGVKVMSMGLIVPYDEAIAVRGPMVNKYIRALLFQTDWEELDYLLIDMPPGTNDVHLTITQEVMLSGAVIVSTPQKVALIDVRRGIDMFAAVNAPVLGLVENMSYFKCDSCDKRHYMFGRDGVARAAEELGVPFLGEIPFLSRIMQDTDEGVPPALRGDATLEAAKPYYELAERIHATLGESERNRAGDGSGKDVGQRAPAPEPTIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFG5</accession>
    <name>A0A3Q8IFG5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium stibogluconate resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFG5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_073400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310951.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1500"/>
    <dbReference type="OrthoDB" id="261177at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744:SF1">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40744">
        <property type="entry name" value="SODIUM STIBOGLUCONATE RESISTANCE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="621" mass="67981" checksum="1DE338D4884FD180" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFH6</accession>
    <name>A0A3Q8IFH6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sfi1 spindle body family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310018300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFH6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1910"/>
    <dbReference type="OrthoDB" id="265851at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="967"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120740" checksum="3AAF72EA8269AC1A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFH7</accession>
    <name>A0A3Q8IFH7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amastin-like surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340023100</name>
        <name evidence="4" type="ORF">LdCL_340023200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFH7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340023200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2540"/>
    <dbReference type="OrthoDB" id="267567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22695" checksum="D8EE6B297D6BB254" modified="2019-04-10" version="1">MKYNIPLILYVVLQLVAFILLLAGTPSDIFIRTDHGPGYPTICLTLWGFKTDCSSRHHTLTIDRTFGACPPRVHRFRAAQAFTIISILVYGAAFIAGLTLLFCCSFLRLVCLALNIVGSVTLCVVWAAMAVTYNKADGPQCTRLSEVYKYGSGFVLFLIAWLLDIINIIILLLPYTGDLVHEDEKSESQTAPEEMEMAQENAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGB8</accession>
    <name>A0A3Q8IGB8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metal-ion transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_310032700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGB8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4450"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="62"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="356"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="451" mass="48282" checksum="5EDC6E9291C91C37" modified="2019-04-10" version="1">MSPEQPRETTGLTAAPAGPAATNYHTASNTVHVTVAEERTIDEALSVVNARRESEKKVLLGALIFCFVFMIVEFASGVIAHSLALLTDAIHLLTDVGSYALSIGALVAAGRAACGRYSYGWHRAEVIGTLISVFSIWALVTWIVIEAGYRTYDMYMCSRVPAQASAGAVKARECQAVDSRLMILVGVLGMLVNVVCASILYFGGSHGHSHFGSSHGHSHGESEMHDHDHSHRDLHEGGHGHNHAHDDRHDHGHDHGHGHGYLAESGGGIGSHKGFAVHAAILHAMGDCVQSIGVIFAGSFIYFSNLAYYGNHTYEHSLFNLADPFCSVMFALITLSMTKALLMDLLSILMESTPASVDYYALETALQQIDGVASVHDLHVWSLSAEYVSLSVHLVADNAAEALQKAQHICKEHFGIGHTTIQIDSVAVGTAGCASACASPTAHDEILSHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGE1</accession>
    <accession>E9BN53</accession>
    <name>A0A3Q8IGE1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Endoplasmic_Reticulum-Golgi_Inediate_Compartment_ (ERGIC)/Endoplasmic_reticulum_vesicle_transporter_putative/ Pfam:PF13850/Pfam:PF07970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_312830</name>
        <name evidence="10" type="ORF">LdCL_310036600</name>
        <name evidence="11" type="ORF">LDHU3_31.4950</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863369.1">
        <property type="nucleotide sequence ID" value="XM_003863321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGE1"/>
    <dbReference type="GeneID" id="13389702"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4950"/>
    <dbReference type="OMA" id="GPTHGMY"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="208"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5432706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ36681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="467" mass="51602" checksum="0052C8A862A9BE7A" modified="2019-04-10" version="1">MPPFFVNSPSNASDLLRHAATTAAPLRQPPQVHPGTARVLHTRARWLVLSHSYLSTKRVHTMRQLKRLDVFPKFDRKFEQDARHRTVSGGVLSVVAIVVIIWLLVGEVRYFLSVEEHQEMFVDTKVGGDMQVTVNVTFNHVPCDLITLDAVDIFGVFANDVEGNTVKQRIDAATGQVISAARAMVDEKKVMTKAIDADGAEKENCPSCYGAERNPGDCCHTCEDVRQAYARRGWKLDIDEISVEQCAEDRIKMAAAASGKEGCNLYATFAASRATGSLQFIPGRIYETLGRRMHDLMGSTTRKLDLSHTVHTLEFGDPFPGQQNPLDGTAQGSALSGDAKDAMNGRFSYFVKLVPTTYQRYSLITGLQDAVESNQYSATHHFTPSEAAKAVSQTPKKQEIVPGVFMTYDLSPVRILVQERHPYPSLVHFVLQLCAVCGGVLTVVGLVDSMCFHSVRKIRKMCTGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGF3</accession>
    <name>A0A3Q8IGF3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_350036600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350036600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4150"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF4">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1487"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1487"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1626" mass="173216" checksum="14698DE869489137" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH30</accession>
    <accession>E9BP91</accession>
    <name>A0A3Q8IH30_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">50S ribosome-binding GTPase/Miro-like protein/Ras family, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Miro-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_21205</name>
        <name evidence="2" type="ORF">LDBPK_323410</name>
        <name evidence="1" type="ORF">LdCL_320040000</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863752.1">
        <property type="nucleotide sequence ID" value="XM_003863704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH30"/>
    <dbReference type="GeneID" id="13391278"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320040000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4290"/>
    <dbReference type="OMA" id="NERHDQE"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002311">
        <property type="entry name" value="Intraflagellar transport protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="218" mass="24222" checksum="933E452950B09E8E" modified="2019-04-10" version="1">MAEEKIKIIVVGPVKSGKTTITNFLSGTRETATSKYYETNPLRIVETEIELDSMNLTDRRVVFSGGDAKTKRVLVQIWDLSGNSKHQAGWPAVANGADGIIFVFDPALRNGEKELSLWHKTFAVNQSELDALGNFAVRVPDKHCLVFAHHSTPPNNVAGEGLPSMPKGLEKIKVLETSLDYHSDNFKAAFDKLIESIVVARMEAEEDEVLQREGRMHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II13</accession>
    <name>A0A3Q8II13_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350012600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II13"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350012600"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12990" checksum="36D7D81C1CDB4CF5" modified="2019-04-10" version="1">MSYAQRHRNRVELHYHEVAQPPHGFYAASAAVHNGRAPVRLQDTVIGTQDQEPLPRGGSGPRLSNSSLQRSSGSGNRASDAHDSYTACYPHPHSIIGASAAAAWCETTPSVSGARMPRQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II15</accession>
    <name>A0A3Q8II15_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340019100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II15"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340019100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2050"/>
    <dbReference type="OrthoDB" id="267176at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51481" checksum="9176140B3CB7E119" modified="2019-04-10" version="1">MANVRLAKIGDSASSRPTIVVEKSTAIPPRLPRIGPPAILRLPPQLVIHCFCFCNLQTLGVLCRVSVRMNVLVARQGAELWLAAAQRRRIPISDSACAREELRKALVHRARERQAEEAYYEAEIARMEERLSARAQYIYAQNIDVDRTLKTNGGPPTAAAANPQPFWLRQKRTLQARAGATAGSADTAPTALSQSADMCAKLQTEIEALEEVKRACECRLNLQEELLLQHDAQLRQWQSLLLPCKMSSPKSSLAPASAGAAAASFNTKNESAAAVASSLLLVSAAQVDEFERRMARLVLNGPVSTSSASITHASPGESSLPVVLRRGVENFGSLELVLRAVKRMEPTNDLDPANRDTVTTGNNMNTATAATAAEAASFEGAARAAAKRWGAFQKICPINEEYENARLFLKAQASRAVPAPTAHLHTNTDGGSPANNDEQLQQQPSPKPTPALLRLSDFVRRAEAMSDAQVLQKWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II25</accession>
    <name>A0A3Q8II25_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330038500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II25"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330038500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4530"/>
    <dbReference type="OrthoDB" id="276608at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF7">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="622" mass="65992" checksum="2ACD74F6B964200D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II56</accession>
    <name>A0A3Q8II56_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_350020200</name>
        <name evidence="2" type="ORF">LDHU3_35.2040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II56"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2040"/>
    <dbReference type="OrthoDB" id="265711at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="354" mass="37854" checksum="42FAD67F11F600F5" modified="2019-04-10" version="1">MQLQCDDQPCHRCSRTDAWSFEISGCPPYAVDHGGRADTERVQRDDYVRVPSSPSSSSIRGIHESSITTSTDCHLCPYAASAHRLSATAALSSAKLSPSCRLSWRAHNDSKMTLTLRSIRVSVVRGDSGRRCSFLIQPTFAYTWHRRSTYNGSVDGAQAGIELQETVRCRVSSSIVTQSNSATVGPATATNKIASSTSGSATTPGAATTVSLFEGYPGHLCHNEEASSSALRSDVPGDVFGDGYTYEATQISRCRSIPMSLAGLEESASSLGSCSPALFVDCLIKCAQDEAAVALDDRHGWVHLYRGRHIATEVGRTRLLTDVLALGYFGAASASPIPSCSEPPSLTICVFRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIY4</accession>
    <accession>E9BTN2</accession>
    <name>A0A3Q8IIY4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CGC20_29060</name>
        <name evidence="15" type="ORF">CGC21_13180</name>
        <name evidence="13" type="ORF">LDBPK_361730</name>
        <name evidence="11" type="ORF">LdCL_360022800</name>
        <name evidence="12" type="ORF">LDHU3_36.2290</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="8">
        <citation type="journal article" date="2020" name="J. Med. Chem." volume="63" first="10773" last="10781">
            <title>Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.</title>
            <authorList>
                <person name="Nagle A."/>
                <person name="Biggart A."/>
                <person name="Be C."/>
                <person name="Srinivas H."/>
                <person name="Hein A."/>
                <person name="Caridha D."/>
                <person name="Sciotti R.J."/>
                <person name="Pybus B."/>
                <person name="Kreishman-Deitrick M."/>
                <person name="Bursulaya B."/>
                <person name="Lai Y.H."/>
                <person name="Gao M.Y."/>
                <person name="Liang F."/>
                <person name="Mathison C.J.N."/>
                <person name="Liu X."/>
                <person name="Yeh V."/>
                <person name="Smith J."/>
                <person name="Lerario I."/>
                <person name="Xie Y."/>
                <person name="Chianelli D."/>
                <person name="Gibney M."/>
                <person name="Berman A."/>
                <person name="Chen Y.L."/>
                <person name="Jiricek J."/>
                <person name="Davis L.C."/>
                <person name="Liu X."/>
                <person name="Ballard J."/>
                <person name="Khare S."/>
                <person name="Eggimann F.K."/>
                <person name="Luneau A."/>
                <person name="Groessl T."/>
                <person name="Shapiro M."/>
                <person name="Richmond W."/>
                <person name="Johnson K."/>
                <person name="Rudewicz P.J."/>
                <person name="Rao S.P.S."/>
                <person name="Thompson C."/>
                <person name="Tuntland T."/>
                <person name="Spraggon G."/>
                <person name="Glynne R.J."/>
                <person name="Supek F."/>
                <person name="Wiesmann C."/>
                <person name="Molteni V."/>
            </authorList>
            <dbReference type="PubMed" id="32667203"/>
            <dbReference type="DOI" id="10.1021/acs.jmedchem.0c00499"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (3.20 ANGSTROMS) OF 100-302</scope>
    </reference>
    <reference evidence="12" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865288.1">
        <property type="nucleotide sequence ID" value="XM_003865240.1"/>
    </dbReference>
    <dbReference type="PDB" id="6TCZ">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="L/l=1-302"/>
    </dbReference>
    <dbReference type="PDB" id="6TD5">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="L/l=100-302"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIY4"/>
    <dbReference type="SMR" id="A0A3Q8IIY4"/>
    <dbReference type="MEROPS" id="T01.A10"/>
    <dbReference type="GeneID" id="13388174"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2290"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000034">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20 21" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ38611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP48286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6TCZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="6TD5"/>
        </source>
    </evidence>
    <sequence length="302" mass="33616" checksum="A27682C0059D25A8" modified="2019-04-10" version="1">MFADFESVMSSNFTLDDCPRVGPFTYHNMDEDTLEEPLSLCSYRRAPQQTTERSPASCDAVTADPLDSSRYLHGENRCWTLTASCPVPRAIPKIDMKKGTTTLAFRFNGGIIVAVDSRASTGQYIASQTVLKVLEINDYLLGTLAGGAADCQYWERVLGMECRLWELRNGSRITVAAASKILANITYAYRNHGLSMGTMLAGWDQFGPSLYYVDDKGSRVKQDLFSVGSGSIYAYGVLDTGYRKDLSVEDACDLARRSIFHATYRDGASGGIVTVYHVHEKGWTKISRDDQTKLYDRYFPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ96</accession>
    <accession>E9BD32</accession>
    <name>A0A3Q8IJ96_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DnaJ_domain_containing_protein_putative/Pfam:PF00 226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_170050</name>
        <name evidence="3" type="ORF">LdCL_170005500</name>
        <name evidence="4" type="ORF">LDHU3_17.0070</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859865.1">
        <property type="nucleotide sequence ID" value="XM_003859817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ96"/>
    <dbReference type="SMR" id="A0A3Q8IJ96"/>
    <dbReference type="GeneID" id="13393325"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0070"/>
    <dbReference type="OMA" id="PVSLWHQ"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000146">
        <property type="entry name" value="Chaperone protein DNAj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="262" mass="29590" checksum="92FD86179B16B906" modified="2019-04-10" version="1">MRRWTASAAPAAVQRQSCLLALRCATTGVQHSYKPGCFVLALRSLFVTLTPTSLKRRIAIRMQTGMERTEELERQLQWLQKHGSPLQVMGLPNHAELAEVRARYRSLVLETHPDTAKNTTGESEYAILQTAYKMSVNPASLWHQNGASPALHRQLLQTSKKSLRRLDRVHVFATFSYAVMLAIGVFFSTVVVSNGLEAALKFFDPEFYHFMVQQEKEEDRKRAAGEVVNTDPKRLAPTAVRRLLFPGQFIHEGDEGKARRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IK45</accession>
    <accession>E9BV50</accession>
    <name>A0A3Q8IK45_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_18770</name>
        <name evidence="5" type="ORF">CGC21_38695</name>
        <name evidence="3" type="ORF">LDBPK_366940</name>
        <name evidence="2" type="ORF">LdCL_360081900</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865805.1">
        <property type="nucleotide sequence ID" value="XM_003865757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IK45"/>
    <dbReference type="GeneID" id="13386659"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360081900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9260"/>
    <dbReference type="OMA" id="PRWYPLF"/>
    <dbReference type="OrthoDB" id="277304at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23713">
        <property type="entry name" value="RESC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="187" mass="21390" checksum="D89D151EEA7166DA" modified="2019-04-10" version="1">MRRGAVLLLRVERPLTPGSLLQTIRSDPGMTTTYYANRYFGQENVMQLNHLLWGVLKRNGKVDIDRADGKDAAPRWYPLFSNPKRHQVRPHNPDEEDLSFLRNTPPTAPTAPEMPADTPASVSRADSCELESAIVELVQAVPGKDIHFYIMELPFQYRRSAPRAFKRLRETGLLMREATNLGTYVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKU6</accession>
    <name>A0A3Q8IKU6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320014300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKU6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1120"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="466" mass="50989" checksum="ACA59411269AB58C" modified="2019-04-10" version="1">MSQESSTSPPTRADRHKTSTSPSRSGSTSSSNTNIPCETALQLGPTLWVEMWENQRWYPVIGWGTSRFLTDLPVFCFVPPAYRLCGAHPNDFDAAFHSVNPPSPHSPNPQWPARRILTVVLPAGYRWVGFWEVHTEHPHGTDTAGWRYGEQFLRPVDGANADPANAASPQQVLAPFKKTHTPLCVVRRRLWRRRVALAGVDEPASSTDDLFPGHSEQQLHSYLSEKEEEMEMAEHLKEAEFMAAQAGEPWSQEQQMRAEEELRKFCRERQNRESASRMRTINPSFANPFRQPEGSFHVSPDDDDGPTDVNAHPEEQFSGAVAAASWVRDSRSNRAAPAVSSPVATPDDTTAEHSAESSHGGCTVEAYSTTAPSRVDGSDLVGQNTVQEFVASTPTDAERSRTDGADAAAENAVDQFVASSPTDPAALSNDDQSTGVSIGGIRDPTDADFRAIFSQFMTPSGGQKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IM74</accession>
    <accession>E9BS70</accession>
    <name>A0A3Q8IM74_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_351970</name>
        <name evidence="2" type="ORF">LdCL_350024900</name>
        <name evidence="3" type="ORF">LDHU3_35.2580</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864779.1">
        <property type="nucleotide sequence ID" value="XM_003864731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IM74"/>
    <dbReference type="GeneID" id="13387658"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2580"/>
    <dbReference type="OMA" id="VHEESDC"/>
    <dbReference type="OrthoDB" id="269605at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="590" mass="67563" checksum="558FE02B7667C935" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMT8</accession>
    <accession>E9BSS7</accession>
    <name>A0A3Q8IMT8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/beta hydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Bem46-like serine peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Bem46-like_serine_peptidase/GeneDB:LmjF.35.4020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_14720</name>
        <name evidence="7" type="ORF">CGC21_7480</name>
        <name evidence="6" type="ORF">LDBPK_354070</name>
        <name evidence="4" type="ORF">LdCL_350045800</name>
        <name evidence="5" type="ORF">LDHU3_35.5290</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864985.1">
        <property type="nucleotide sequence ID" value="XM_003864937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMT8"/>
    <dbReference type="GeneID" id="13387863"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350045800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5290"/>
    <dbReference type="OMA" id="CAVMMVD"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP44663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="394" mass="42682" checksum="D9BF42B246202E3C" modified="2019-04-10" version="1">MSFGGFLLSAGLYLVLVAVFVSLFLHIMSYRYRSQQNRLLYYPQIPPESREVCEDPVTLGIPYAERVCVTTADKVRLSGYMLWPAPAPSTEKSGNASVPESIGRASSNAATAEGGTHAEVDASGGATDSTSAGSVVPGSSRSVTMSSGMPSFVMLYFHGNAGNVGHRLPLAQAFVAHLKCAVMMVDYRGFGLSDDSEQTQETLELDAQACFDYLWQDPRVPRDRIIVMGTSLGGAVSIHLAANERYARRIAAVIVENSFSSISDMASALSRPILTKLASQCPGLAVGIFEYYVKPLALRISWNSAQKITKVVVPMLFLSGMRDEIVPPEQMRTLYKAATKCLRDGNGSDLTVPLRRFLEFEDGRHNNLPLMPGYMSALQDFVTDVRNAGAAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPR6</accession>
    <name>A0A3Q8IPR6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cdc2-related kinase 6, putative</fullName>
            <ecNumber evidence="7">2.7.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Protein kinase domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_31190</name>
        <name evidence="7" type="ORF">LdCL_270010500</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPR6"/>
    <dbReference type="SMR" id="A0A3Q8IPR6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0730"/>
    <dbReference type="OrthoDB" id="255890at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000821">
        <property type="entry name" value="Cdc2-related kinase 6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF417">
        <property type="entry name" value="CONTROL PROTEIN 2 HOMOLOG 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="327" mass="37395" checksum="F754E6707A1BA86F" modified="2019-04-10" version="1">MSASVNNLDGKLDLVDITALSAAYEPEEVLGEGTYGIVFRARNKATGAKYAIKKLRLDGFSEGVPATTIREATLLHDLNDNPNVVKLLDVVCSDHRVYLVFELLDEDLRIFIKRYRPVSGQKPINGTAVPLHLVREFTRQILYALWTCHNNRILHRDLKPGNILVANYRSKNGETKFYVKLADFGLARMFEMSVQTYTHEVMTLWYRSPEIILGDRHYTPAADVWSVGCIVAEMILGYSLFRGENWRDQLDKVFYVVGTPTEQTWPGVTKLPGYDRNFKVYHVAPLPTRLRDYDEKAVEFIAYLLVTNPKLRPTIPDILEHPFMKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQL8</accession>
    <accession>E9BJN8</accession>
    <name>A0A3Q8IQL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_22275</name>
        <name evidence="4" type="ORF">LDBPK_281670</name>
        <name evidence="3" type="ORF">LdCL_280021400</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862266.1">
        <property type="nucleotide sequence ID" value="XM_003862218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQL8"/>
    <dbReference type="GeneID" id="13387002"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2140"/>
    <dbReference type="OMA" id="HLSWTRT"/>
    <dbReference type="OrthoDB" id="264874at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="860" mass="91691" checksum="7E342B04948FE021" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISX7</accession>
    <name>A0A3Q8ISX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310039300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310039300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5310"/>
    <dbReference type="OrthoDB" id="273749at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1789"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="772"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1659"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1758"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1800"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1855"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1870"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1953" mass="217444" checksum="2157668BC4019561" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H515</accession>
    <name>A0A3S5H515_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_020012200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H515"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0830"/>
    <dbReference type="OrthoDB" id="273844at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="454" mass="49882" checksum="8DACA27151C8FC81" modified="2019-04-10" version="1">MHRSTRQRHAPPAAARRAENATVPSSLKKDPLPVCKRREAATRSAQLTDLFDSLSAADAKALQSTQLGEDFADDFTNEGAEGLLSATLFSRRPPLSTSAPPDHAANGVSSSSTGELVLRSGRAAAPSTNSHDLPRPFHEQALAVRSVEVAATEMQSTLQQLQHDLAFHVKRRIEAEREAGGHLASAPRPRPSSDSESITPLRAETTAAQKRRMADPDVLSEAARIQRARAAAADEGLSDDQSVEDYGVDCEVPPLTSDSRLVDEVAAIAVCMAKMKESAKVMYDTEATAPSTSTAPWWSSALHMRDMKASAARLDYHAHTALNWSHRSMEQLLLQAVMLNNVSVSTRTQLLEQQQHWQEFQTRLRDGQQTVTQLQADIARYQARVQAEMARRAALQEELRLCAQERGLVDPGERNPLKAELALLLEEREWPSPTLKKDASVVLDWLRSVSTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H570</accession>
    <name>A0A3S5H570_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_030014700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H570"/>
    <dbReference type="SMR" id="A0A3S5H570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.1050"/>
    <dbReference type="OrthoDB" id="268388at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="104" mass="12457" checksum="B6F5F6BC464C8086" modified="2019-04-10" version="1">MVYTRWKCDRIPVLQLKLFTQEYNMMAVVGLLSMVFLFKHASYCSEETERKNGWWAGYPYWRDPIARRNEIRYKQLINSNDVDITDPKWTGCSKEQLERLCAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5X7</accession>
    <name>A0A3S5H5X7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070009200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5X7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0500"/>
    <dbReference type="OrthoDB" id="273369at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="928" mass="98254" checksum="28279E89EBCA956C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6B0</accession>
    <name>A0A3S5H6B0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_090006300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6B0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090006300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0190"/>
    <dbReference type="OrthoDB" id="273140at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF9">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="711" mass="79142" checksum="24EE70AD01676107" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6D5</accession>
    <accession>E9B9U4</accession>
    <name>A0A3S5H6D5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_090570</name>
        <name evidence="2" type="ORF">LdCL_090010800</name>
        <name evidence="3" type="ORF">LDHU3_09.0700</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858737.1">
        <property type="nucleotide sequence ID" value="XM_003858689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6D5"/>
    <dbReference type="GeneID" id="13392088"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0700"/>
    <dbReference type="OMA" id="FRYWFLS"/>
    <dbReference type="OrthoDB" id="270010at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="770" mass="86933" checksum="A5D6E5670D78FC1D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6E9</accession>
    <name>A0A3S5H6E9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_090021500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6E9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090021500"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16994" checksum="627B8BA9A09BBFAD" modified="2019-04-10" version="1">MISAYQVLNGALNQLRKSIGAAECMLTVLEVKTDLAPTKGSETATAGVESRVLDCICLHHQARRGRIVLISISGEFPHSSVTAIVGGSGGGKSTTMLCMYEPQVMCVLVDGRDIRDLLFKWLHHQCAVVAQDMQSSAVLLRTTSATDWRRPRMRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6F8</accession>
    <name>A0A3S5H6F8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIF1-like helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_100010200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6F8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100010200"/>
    <dbReference type="OrthoDB" id="268375at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="296" mass="30711" checksum="C5138B82181D8A1B" modified="2019-04-10" version="1">MRDGVHRFGPRGLARCVDCVEGGGGDSAVRRHAHNPRHALIHGSSAVPAAIPLPSLSASLWVRLLPGAPLTPSRQPPFRPRSNPPNGHCHHHHSTHARTHTASSSATSLVVPPLLCSTPARRCVAHSSVGATPHWAGETTRTGEGGRCCCSPAPCLSHCLGWPPLHGALVGALRPLVGGRACTRAPMGPLVSAPGLLASLSVPRPAVLRQRTPAQLMRTAHPSRGDGGERRACGTSTHAVTAAVVPTRFPWSLACSVPASLSARRSTLRGADGRSANQNCTEDALLCAVAVPLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J9</accession>
    <accession>E9BAW3</accession>
    <name>A0A3S5H6J9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TatD related DNase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TatD related deoxyribonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_0645</name>
        <name evidence="7" type="ORF">LDBPK_111270</name>
        <name evidence="6" type="ORF">LdCL_110018600</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP52977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859100.1">
        <property type="nucleotide sequence ID" value="XM_003859052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J9"/>
    <dbReference type="SMR" id="A0A3S5H6J9"/>
    <dbReference type="GeneID" id="13389800"/>
    <dbReference type="KEGG" id="ldo:LDBPK_111270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1580"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000040">
        <property type="entry name" value="Putative tatD related deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP52977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="336" mass="37287" checksum="F5C47D74794A6E30" modified="2019-04-10" version="1">MTKLPQSCAPWRLIDIGLNLTDHMYKGVYNGRQQHTSDIESILQRAVEVGVRGLLLTGGNLMDSKAVIDMCARYNSDTLQCFCTVGCHPTRCQEFVDDPDGYLKALDDLVRKHSVHVGGCVAAVGEIGLDYDRLSFCPKEIQKEYFEKQLVMAKRHRLPLFLHERNTVGDFKALLEPHLPELAGGVVHSFTGSRAELQEYLDANLYIGVNGCSLKTAENLETVKAIPLDRLMLETDAPWCELKGTHASKALLTAAAKRASSQQSVSDTILAAFPTCRKDKFKKGCVVKGRNEPCAIVRVLEVVYELRREEVSSMEQLAEVVLTTTRKLFPFAASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6N3</accession>
    <name>A0A3S5H6N3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_130008900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6N3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0510"/>
    <dbReference type="OrthoDB" id="258593at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="497" mass="55584" checksum="C5576C3B410FE24B" modified="2019-04-10" version="1">MVSGLVELEILRGKNYPQTEDDPNPCTTQVTVSVADALSGAVLSPAQLSSIQQNSNAPFYNDTLNFRVEDASEDVCLSITVSEHSRRKMPFVLFYGKQIIGLSKLKAKQRFVIPLFSEEEGIQQVEIGADTLDLESSGGAPFLSARVQFTKDKIFDKTDPYSDVDVSGKGLSFDGKNQLVPEGTQYVWLRLKSDNKWTNSFQYELSVAWRSRAPLETEAQGNMKSRKGITGGMAAISAEPDSTRTLGDIIIKKWCCRRTHQVLTRVCITAEKYGNKVTDLTFTPKEEVEFRTNKKERCVFLEQICKKRLEDACSNCLREWLNRLWILFVTGVDSDPAGPRALSYEVRKAVHDAQFTEADAIILQACLLFSFIPSLKYEVCQALSESDYQAAQPEKKIEVSTLESPQRRVTPSQETFTHVFISFVGSLLDTLTEAEIAKAAAEFKPAIWDAQQRIAKGAKSTIGSCRKKYEGSIFKGSGIHIDHLDKLGRRKQVPKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Z9</accession>
    <name>A0A3S5H6Z9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_170007600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Z9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0420"/>
    <dbReference type="OrthoDB" id="264693at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="667" mass="70650" checksum="5AAF17C49787812D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7M0</accession>
    <accession>E9BL75</accession>
    <name>A0A3S5H7M0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_292780</name>
        <name evidence="12" type="ORF">LdCL_290033900</name>
        <name evidence="13" type="ORF">LDHU3_29.4090</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ36003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862696.1">
        <property type="nucleotide sequence ID" value="XM_003862648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7M0"/>
    <dbReference type="GeneID" id="13385399"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290033900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.4090"/>
    <dbReference type="OMA" id="AESMIGT"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001074">
        <property type="entry name" value="Putative serine/threonine-protein kinase Nek3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000971">
        <property type="entry name" value="Putative serine/threonine-protein kinase Nek3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5431995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ36003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="522" mass="57491" checksum="F37E8A35B393C7E2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7W6</accession>
    <name>A0A3S5H7W6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amastin surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340023300</name>
        <name evidence="3" type="ORF">LdCL_340023400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7W6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340023400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2560"/>
    <dbReference type="OrthoDB" id="267567at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="199" mass="22280" checksum="4DD6BEAC69D9B003" modified="2019-04-10" version="1">MSPFPLSTSYCYFRQKKYNVSLVVYVVLQFFAFLFVLVGTPSDMFRERFRGGDPLCITLWGLRVTCSSSDYLLFIEMYWSDCRGRVARFRAAQGCAIISVFVFAAALIAGLTLLFCCSSLRLVCLALNIVGSVTVFVVWVAMATTFHHNDGSRCPPMKVDSVYGSGFVLFLIAWLLDIINIILLLPYTPMDADPNERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNZ9</accession>
    <name>A0A3S7WNZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_050006500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNZ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0200"/>
    <dbReference type="OrthoDB" id="267652at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="513" mass="55956" checksum="4C9F130E6CBDEC6C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPR5</accession>
    <name>A0A3S7WPR5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_070006800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPR5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0230"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001566">
        <property type="entry name" value="Protein_kinase_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF102">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115326" checksum="020BA665370C6184" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRC4</accession>
    <accession>E9BAH3</accession>
    <name>A0A3S7WRC4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-finger in Ran binding protein and others family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Zn-finger in Ran binding protein and others, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_23270</name>
        <name evidence="7" type="ORF">LDBPK_101290</name>
        <name evidence="6" type="ORF">LdCL_100019900</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858963.1">
        <property type="nucleotide sequence ID" value="XM_003858915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRC4"/>
    <dbReference type="GeneID" id="13389478"/>
    <dbReference type="KEGG" id="ldo:LDBPK_101290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_101290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.1650"/>
    <dbReference type="OMA" id="ETTLWTC"/>
    <dbReference type="OrthoDB" id="247415at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP46547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="189" mass="20643" checksum="37342CE86B3F9C35" modified="2019-05-08" version="1">MLRCHGGLGARFLRRPCGAAAAAVVYPATSGAVAGMAMTSSKTCTYVRSFSTATPLCLARRLAGNHRRKRSREPTKGDWLCQCGEVNYQSKRECYKCGAPAPPLPPGVRRPSLPGEDPHDWACPCGQMNFRGAVVCHKCQQPKPVPPPLPGKETTLWTCPKCKGVNRNNRRFCFKCSAPSPLVEFKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTH7</accession>
    <name>A0A3S7WTH7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_150012800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTH7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150012800"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8311" checksum="8433068196E6249A" modified="2019-05-08" version="1">MSFQPSLLVQYFRADEAFGISPILLNMLTGGFSLVASSFGTMVSCFAITAASPPDEVAPFNDSMQDGQADRCGGISARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTJ2</accession>
    <name>A0A3S7WTJ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_150016700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTJ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1420"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21310" checksum="84FD0677F90E6E9A" modified="2019-05-08" version="1">MSCGDAKINCPAPPFEEVALMPNGSFKKISLAAYKGKWIVLFFYPLDFSFVCPTEIIQFSENVSRFNELNCEVLACSMDSEYAHLQWTLQDRKKGGLGTMAIPMLADKTKSIARAYGVLEEKQGVAYRGLFIIDPNGMVRQITVNDMPVGRNVEEVLRLLEAFQFVEKHGEVCPANWKKGDPGLKVDHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVB1</accession>
    <accession>E9BE22</accession>
    <name>A0A3S7WVB1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_9190</name>
        <name evidence="6" type="ORF">CGC21_19460</name>
        <name evidence="4" type="ORF">LDBPK_190260</name>
        <name evidence="2" type="ORF">LdCL_190007600</name>
        <name evidence="3" type="ORF">LDHU3_19.0300</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860205.1">
        <property type="nucleotide sequence ID" value="XM_003860157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVB1"/>
    <dbReference type="GeneID" id="13386017"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0300"/>
    <dbReference type="OMA" id="EAMSMPP"/>
    <dbReference type="OrthoDB" id="238616at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="960" mass="100095" checksum="E142913F1C13F3F4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWJ6</accession>
    <name>A0A3S7WWJ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 66, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210017800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWJ6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210017800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1500"/>
    <dbReference type="OrthoDB" id="267127at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="825" mass="85967" checksum="5A09A698F700201C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY29</accession>
    <accession>E9BGM7</accession>
    <name>A0A3S7WY29_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_11550</name>
        <name evidence="6" type="ORF">CGC21_15760</name>
        <name evidence="4" type="ORF">LDBPK_240150</name>
        <name evidence="2" type="ORF">LdCL_240006400</name>
        <name evidence="3" type="ORF">LDHU3_24.0180</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861105.1">
        <property type="nucleotide sequence ID" value="XM_003861057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY29"/>
    <dbReference type="SMR" id="A0A3S7WY29"/>
    <dbReference type="GeneID" id="13390555"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0180"/>
    <dbReference type="OMA" id="CYPHTHI"/>
    <dbReference type="OrthoDB" id="276821at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="289" mass="32049" checksum="77297F83C9BBF3A8" modified="2019-05-08" version="1">MATLEKQLQSSTLSKQCRADLLNHVEEVETSSRRLSKKMITLPDSNLPSAVTMPTDNSVKRGIRAATAGANTERSLHYTARKQEKDEMVASRIISDRNLSGTYFKDCSHKFVNGARSWPDPFRSSRSRTALSGKDMDFVYRYAEAATGSAIERPQPSDDASVAATAAYRKAFRQYKGRDPTAKEMEEAGRLVYAFDEHGSVGVLQKPHSCYPHTHISAVKTHIRTCPNQVYLPEVPPVRAARSEFPGPIPTWSSTKRTTTMATNGTYRPGHHQATSLKREAMSTVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYG6</accession>
    <name>A0A3S7WYG6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_240016000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYG6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1280"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="375"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="435" mass="49442" checksum="8E0079A2DEA234E0" modified="2019-05-08" version="1">MLLRTRVLCYTVHTPRGINFDLSADDAIRRIQDKYGRRWLGAQLDYLRLETPSKEFLPFYLCSGRIHASFVGNVSYSVNTTSGDDKSARSSTRYVSTSLQTLDSVFEENKTQIYAGYKYNVAHVHHALRGDQLSYSLRKMYEVDTTGAIINLFEQSTGTMLKFVEMEVRQQAEETARSLVRSFHPSADSVTVEFKEFAFHLDDVTPTFVPCFVVKAEYDAERYTLYVSGLNGHVGGPYLLNSVYIARTTALATLAAALFLVPNKVAGFFFGSVACVATYYAAFFAARWYPVMRRNWNRQKRERLRRENLGLDQAGYRPNTSSQRIQQEYRSSTYWDTHAYQQRRHTGSHGPRSAFSSSSSPYSSFSAHSVADPLGYYRALGLHGDESVNEIRSAYRRIVLKQHPDVGGSSEAMVKANEAYRVLRDPKRRAAYDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ46</accession>
    <accession>E9BHP8</accession>
    <name>A0A3S7WZ46_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surp module family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Surp module, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Surp_module_putative/Pfam:PF01805</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_8765</name>
        <name evidence="5" type="ORF">LDBPK_251440</name>
        <name evidence="3" type="ORF">LdCL_250020000</name>
        <name evidence="4" type="ORF">LDHU3_25.1780</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861474.1">
        <property type="nucleotide sequence ID" value="XM_003861426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ46"/>
    <dbReference type="GeneID" id="13388720"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1780"/>
    <dbReference type="OMA" id="FAPVYMS"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000027">
        <property type="entry name" value="Surp module, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF12">
        <property type="entry name" value="SURP MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="2">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP40755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="395" mass="43516" checksum="33A58831DEC969C1" modified="2019-05-08" version="1">MENEEALPTIVTPGPELREKVDAFAARLSALDRRKADEMVAKLLASSKRNQFLFVDTSHIFYPYFLSKLTEFRQHPELRPQKPGEHKDRDGAAGSDKGAATMTKVGTITRTMGGTAGAKSDPQREELLRQTEAEARRYLEDPFPNHYSLDRKAGTVDVTALLMDVLSTTAQYTAKYGDRFLAAVQSKQRHNPMFHFLHEDDVRHDMFRKLVESYRRILAFDEEETETRLENLESQSYLLGTVCEEKKKYAKAALARRRAALLTDEELRGRLQWTLFSVVKTFRLSDLQLDGPVPETAASKQHAAQAANANFISPALTSTSKPCATGAEAPPSVPPAAAASGGLTTARANTLLHPPGVASPSFAPVYMSSTLVKGTGSNGKRPRERGGPREAQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZZ1</accession>
    <name>A0A3S7WZZ1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_260023500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2340"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001009">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1900"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2516"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1519"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1920"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1936"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2525"/>
            <end position="2534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2772" mass="297405" checksum="0676EACAD75B25D7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X163</accession>
    <name>A0A3S7X163_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="7">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="7">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KATNA1</name>
        <name evidence="10" type="ORF">LdCL_280008900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X163"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0510"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000142">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="278"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="286"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="530" mass="57895" checksum="808FA2B0E5D1EC55" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1A3</accession>
    <name>A0A3S7X1A3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">LdCL_280011100</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0820"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000013">
        <property type="entry name" value="Dynein Heavy Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000009">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000045">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000020">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000005">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002429">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000030">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="16">
        <location>
            <begin position="919"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="1472"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="21">
        <location>
            <begin position="1974"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="22">
        <location>
            <begin position="2369"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="19">
        <location>
            <begin position="2511"/>
            <end position="2774"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="18">
        <location>
            <begin position="2788"/>
            <end position="3144"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="20">
        <location>
            <begin position="3170"/>
            <end position="3391"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="3654"/>
            <end position="3767"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="23">
        <location>
            <begin position="3799"/>
            <end position="3937"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="24">
        <location>
            <begin position="3943"/>
            <end position="4245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2833"/>
            <end position="2860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3040"/>
            <end position="3088"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3325"/>
            <end position="3384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AYU80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4250" mass="478384" checksum="274D6753BCBF5AD4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2A2</accession>
    <accession>E9BKP8</accession>
    <name>A0A3S7X2A2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-1 protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">A-1_protein_putative/GeneDB:LmjF.29.0935</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_291020</name>
        <name evidence="2" type="ORF">LdCL_290014600</name>
        <name evidence="3" type="ORF">LDHU3_29.1390</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862519.1">
        <property type="nucleotide sequence ID" value="XM_003862471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2A2"/>
    <dbReference type="GeneID" id="13387257"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1390"/>
    <dbReference type="OMA" id="KEATQPM"/>
    <dbReference type="OrthoDB" id="261551at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18947" checksum="F19E2A2F06C09A01" modified="2019-05-08" version="1">MDAARKRHRGNASEAAARGDEDDSAAIPGREARHQVHSSKSAIPFTSTPEEACGDESDYAVLVKRSTALLAKLGQRNVLDNCAAQETSSTQKEATQPMTLPCRFENHKFSLYGVSCSAGSLVLPFATAACIQPTELAHRSTKCTQTESSTTLEARKKLLATELSELYTLLHVFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2F0</accession>
    <name>A0A3S7X2F0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_28300</name>
        <name evidence="2" type="ORF">LdCL_290021000</name>
        <name evidence="3" type="ORF">LDHU3_29.2250</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2F0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2250"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP52785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="143" mass="15257" checksum="0164BFE52B3DA52A" modified="2019-05-08" version="1">MAAASSVRKSKPTTCWRRCCSRSQRDISGRAPAAWKEGLTAPLLKPHRPDGGSTSYRPCGADQRSMQATRTNDRVTTAQSIWATGSSHGILASRAHRSTTDPVGLPHHSVVQRQPGAKTRAGLVSSTLARVARQSAACHHHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2G7</accession>
    <name>A0A3S7X2G7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_290016000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2G7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290016000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1050"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13667" checksum="DE90C33993F932DE" modified="2019-05-08" version="1">MSLAVGPEVMRVVAAKSACHPMYATRPASDIHVKVCIDSIQRTGGRQAMETALQAPRIAAEKLSVTSNDDETGTCNMSALAGVALDHNLGTVCGGKQTCTQLSTDSFKQLTRRKSWDGSWVGFGVPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2T0</accession>
    <name>A0A3S7X2T0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290030400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2T0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3640"/>
    <dbReference type="OrthoDB" id="262895at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="368" mass="40370" checksum="A3027BF750FFB48C" modified="2019-05-08" version="1">MNLQQTTRSVQDLLYTLGTSLERFRGANGLHHLVTTGKLSLLSLFGVFERTRDEEYEKRSAAVNETRRCLLQLVDDFEGITESTEKLARKIDGLLGTLEQFHRCCDMEVDGRANAGDSDASQVGQYFRQIREASSQLKRFLDDFSASKTTCVDVTRTAIKEIEKVNADTSCNVAAALTDFDRQRRRLQMKENEMMHAMSRATSREDPAVRYAELNCVKESEALESLGRKYIDSLGNAMTATHFALEQSSMTGWASSNVFFVQLGQLFSELSAIGKAIAANLLSIKNSQKVSHQLSEEKRRILREQRAAAAAAGVATNIETNLFNGGAGVSSGASSLLAAPSPADPSARVSLPTEGQGRGSVNLDDLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X348</accession>
    <name>A0A3S7X348_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_34925</name>
        <name evidence="2" type="ORF">LdCL_300007200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X348"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0340"/>
    <dbReference type="OrthoDB" id="273716at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP45594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="178" mass="18682" checksum="9BBFE077DCAE6701" modified="2019-05-08" version="1">MRRQQSFTVKAAAGAPATAAVPVEAECLDAPRGFGSGVDISTYRYLDELWAAALLQAEASVLALPHTGSSGLQGAKHTSEADNAGRKETSIKQAADKTGVSSTCNESLLTLSPLPRAPVLPSGSAAHSPVPQPPPPVVVARRSMPSATSKQTWMRVEAQPNLKRNAYTARRGVAWVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3V2</accession>
    <accession>E9BM51</accession>
    <name>A0A3S7X3V2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 7-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Eukaryotic_translation_initiation_factor_3_subuni t_7-like_protein/GeneDB:LmjF.30.3040</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_303080</name>
        <name evidence="6" type="ORF">LdCL_300036400</name>
        <name evidence="7" type="ORF">LDHU3_30.4090</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863019.1">
        <property type="nucleotide sequence ID" value="XM_003862971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3V2"/>
    <dbReference type="GeneID" id="13385728"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4090"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5432332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="531" mass="60614" checksum="D95A47816FA56051" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X428</accession>
    <name>A0A3S7X428_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310008500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X428"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0410"/>
    <dbReference type="OrthoDB" id="10567376at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="247" mass="27177" checksum="4C482CFCB840320D" modified="2019-05-08" version="1">MSANRNHNTNHAPYPQRGQGRLAFDNMPEDLPEYGEDGLHMLNNEHSQEHLADEVVVGASDADGKTKGSKKLESPSLTDDGEPAAKGNKQQSAYMDIAQQIIEADQRNREDRVWRRRHTTNPVLRALQVIMPYGGILASAFSIASSTIGGGIIGLPAAFQMSGMGMAIIFFDCLGDHGDTLLCAARHCVAQDRAVQLGDHRASPDGPRLGLLRRLRHVGALLWRYCLVHHCPQEHPHRLPEELANCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4E4</accession>
    <name>A0A3S7X4E4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310020400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2210"/>
    <dbReference type="OrthoDB" id="266852at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1740"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1859"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1878"/>
            <end position="1902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1902" mass="196678" checksum="594A3069D43F5AF2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4Q7</accession>
    <name>A0A3S7X4Q7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310030700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4Q7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312270.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310030700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4040"/>
    <dbReference type="OrthoDB" id="265773at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="485" mass="53524" checksum="C99B958A6D9B1B6A" modified="2019-05-08" version="1">MGVTCTREKGVVSSSAVIRFGLTRRCSHVERTERPKSFTRETSCRHRSATRARADVCVGCDNSSEALRAVDTVTVPAPEPIEAPLLPSCAERLSSNRNRCHGSTAETTATPSFLVAETPTATRYSMYHIPGGEDDNSYTLVPFKSMYCLPRTTELEPDNFRAMVTHSHAAAAEAPSTEATAYNLKGDDGREKKDAASPKTVSRKAFGTASRTFSRQSLRALRRGFSFGIVSDCADDLVLRHADEMSCMSSVEYGLVRQQESHTDSASCWEVSSIFPRVTISTEADESSSTVLTSQSTLSRRHTFGVMMPTGHSQVVEHTEDGGAWEPALVSPSVRLDARRSWQKQKSSMTVTNLTEEVVVQGGAFPLQDRHHHRHHVGRHCHLVGAAAAVPPRASSHARSKVGRQWPQPIMEGPKSNLSRSRPFNVEATLGYSVRSARFVPSPDWERVCVNEEEKLRLAQVLAAHQQRLKKWKRAQAARWNALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4V9</accession>
    <accession>E9BN35</accession>
    <name>A0A3S7X4V9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquinol-cytochrome-c reductase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Ubiquinol-cytochrome-c_reductase-like_protein/Gen eDB:LmjF.31.2580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_312650</name>
        <name evidence="11" type="ORF">LdCL_310034500</name>
        <name evidence="12" type="ORF">LDHU3_31.4720</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863352.1">
        <property type="nucleotide sequence ID" value="XM_003863304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4V9"/>
    <dbReference type="SMR" id="A0A3S7X4V9"/>
    <dbReference type="GeneID" id="13389684"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312650"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312650.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310034500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4720"/>
    <dbReference type="OMA" id="TIWCDSD"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="10">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5432688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ36663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7925" checksum="5AF44B2124891285" modified="2019-05-08" version="1">MASDPVDIKLDLEKECLANECAKKVGAYNACLERIKTVSPEKEPHCYNQYFAIVHCVDVCVDPKLWPTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4W3</accession>
    <name>A0A3S7X4W3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_10980</name>
        <name evidence="4" type="ORF">LdCL_310034100</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4W3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_013350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310034100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4640"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600689" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="803" mass="86523" checksum="A9EE4F589FCE1B93" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X569</accession>
    <accession>E9BNF4</accession>
    <name>A0A3S7X569_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_33565</name>
        <name evidence="3" type="ORF">CGC21_19810</name>
        <name evidence="2" type="ORF">LDBPK_320500</name>
        <name evidence="1" type="ORF">LdCL_320010500</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863468.1">
        <property type="nucleotide sequence ID" value="XM_003863420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X569"/>
    <dbReference type="GeneID" id="13390280"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320010500"/>
    <dbReference type="OMA" id="SAHHCIY"/>
    <dbReference type="OrthoDB" id="275969at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="101" mass="11563" checksum="292969D545FCA85A" modified="2019-05-08" version="1">MKITITTKMVGFPVFDSTAEYDTNDQLYAVVDQIKRRHGSTVSRIQLWKSKVEPTMILRDHLQPLSNIFGGEEQGSESSAYHCIYYDFSPRESNCTILNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5B2</accession>
    <name>A0A3S7X5B2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Dynein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Dynein_putative/GeneDB:LmjF.32.1060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_320016900</name>
        <name evidence="15" type="ORF">LDHU3_32.1470</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5B2"/>
    <dbReference type="SMR" id="A0A3S7X5B2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1470"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000745">
        <property type="entry name" value="Dynein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001805">
        <property type="entry name" value="Putative dynein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5432869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="601" mass="67959" checksum="52BE100B9A597A68" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5E6</accession>
    <name>A0A3S7X5E6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_320018500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5E6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1640"/>
    <dbReference type="OrthoDB" id="277958at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="797" mass="87509" checksum="EE428B09628533E9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5F7</accession>
    <name>A0A3S7X5F7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320020200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5F7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1840"/>
    <dbReference type="OrthoDB" id="271940at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="750" mass="80814" checksum="9E9D9BBB26D2BA48" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7V0</accession>
    <name>A0A3S7X7V0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine phosphatase isoform, putative</fullName>
            <ecNumber evidence="6">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340021600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="6"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7V0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2340"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14510">
        <property type="entry name" value="PTP_VSP_TPTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045102">
        <property type="entry name" value="PTP_VSP_TPTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF60">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="576" mass="66255" checksum="11980E90D5C107ED" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8L9</accession>
    <name>A0A3S7X8L9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340050200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8L9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_344080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340050200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6390"/>
    <dbReference type="OrthoDB" id="273534at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="63215" checksum="9E9B6551EE5BBB58" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X900</accession>
    <name>A0A3S7X900_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350010400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350010400"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="170" mass="19030" checksum="31AC660BEA0B2C36" modified="2019-05-08" version="1">MARSCCWTAQTTRTPTARSCCWTAQTTRTLTAWSCCWTAQTTTTPMARSCCWTAQTTRTPTARSCCWTAQTTRTPTARSCCWTAQTTRTPTARSCCWTAQATRTPTARSCCWTAQTTRTPTARSCCWTRADDETRRRGAAAGRRRRRATPTARAAAGRRRRRGRDARSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAE5</accession>
    <name>A0A3S7XAE5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">cAMP binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360013900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1160"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000253">
        <property type="entry name" value="Cyclic nucleotide-gated potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000594">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1716"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1827" mass="198274" checksum="2F28F7AD17CDB98A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBC0</accession>
    <accession>E9BU89</accession>
    <name>A0A3S7XBC0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_28090</name>
        <name evidence="9" type="ORF">CGC21_14190</name>
        <name evidence="7" type="ORF">LDBPK_363810</name>
        <name evidence="6" type="ORF">LdCL_360045100</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865495.1">
        <property type="nucleotide sequence ID" value="XM_003865447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBC0"/>
    <dbReference type="SMR" id="A0A3S7XBC0"/>
    <dbReference type="GeneID" id="13388381"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360045100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5140"/>
    <dbReference type="OMA" id="HYMFSTE"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="393" mass="42749" checksum="FD37545FB63BCC60" modified="2019-05-08" version="1">MQEIIDTVNRYTLRSAAFRDKPTPGLAARQFLCSLLLHRKLDSIRLSSIALYMFSTEALIAVSRDGIQTISCEGNTLWPICSIPNGLTSEISGVAVTPEGTLVCSSNGICYLEGGNLRVTEDCASSSYAQNVLCISCTPDGKYIATGGGTATVTVWTSDLKPLHHFAGHTDWVRFVKFARGRSPALQLFSTGDDGVICQWDVLAGSLISRVDYSLGESIQLFEVSYYSGLIAISSGTSLIALYCPRSDNTTRALGEDVLRLQPMALITGAHDYTPTAGKFTDDSQWLASASEDETIALTYVLDPQTCFVCKEFVTRRRCFSFMNIFNSICILAAPPASSVIIIAACSSDGTVVQWVVDPRTNRATYTKKLQLHLGSFLGMDLIPGDDLNHLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XCF7</accession>
    <accession>E9BV55</accession>
    <name>A0A3S7XCF7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_18745</name>
        <name evidence="6" type="ORF">CGC21_38720</name>
        <name evidence="4" type="ORF">LDBPK_366990</name>
        <name evidence="2" type="ORF">LdCL_360082500</name>
        <name evidence="3" type="ORF">LDHU3_36.9330</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865810.1">
        <property type="nucleotide sequence ID" value="XM_003865762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XCF7"/>
    <dbReference type="SMR" id="A0A3S7XCF7"/>
    <dbReference type="GeneID" id="13386664"/>
    <dbReference type="KEGG" id="ldo:LDBPK_366990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360082500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9330"/>
    <dbReference type="OMA" id="MEKTAHE"/>
    <dbReference type="OrthoDB" id="271688at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5435288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP53360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="162" mass="18607" checksum="678F30EA346C6A06" modified="2019-05-08" version="1">MPPKGFKSNVSPEEVIAARREKLEFLSQQCAAVEKMLSICTDQGLRLNAEIAELERRIAETEVMTEQESRDLDVKLKIVTNYATSNLDQLQQRRLNMEKTAHEAEAENEALRVKIAELTERREAEIAQWEAKAEEQRALMNQKALDFGMQLKETLARRYATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCE2</accession>
    <accession>A0A3S5H6V3</accession>
    <name>E9BCE2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_151030</name>
        <name evidence="10" type="ORF">LdCL_150015800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859626.1">
        <property type="nucleotide sequence ID" value="XM_003859578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCE2"/>
    <dbReference type="GeneID" id="13393013"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150015800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1320"/>
    <dbReference type="OMA" id="ACCKADQ"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="PhylomeDB" id="E9BCE2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000531">
        <property type="entry name" value="NAD/FAD dependent dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="400" mass="43254" checksum="E4D0D3CDB50DF919" modified="2011-04-05" version="1">MPLSSSPAPKRFSAEVRDDNPYSRLMALQRMGVVDDYESIRDKAVAIIGAGGVGSVVAEMLTRCGIGKLLLFDYDTVEMANMNRLFYRPEQQGMKKVEAAKETLEGINPDTVIEPHAYNITSTEHWQRFSEALTKGGVSPNSPIDLLLCCVDNFQARLTVNLACLTYEVPWMESGVAENAVSGHIQLLLPGVTPCYECCPPLVVATGLPEAKREGVCAASLPTTMGIVAGFLAQNTLKYLLQFGDVSEYVGYDAMRDHFPRVELKANPECRNALCGERQAAYAAKVRKMGEAAHPLYTARKARADRAEKERQAAQARAKACAAEWDITVEAEGKDSLTVHSGVANIAAALLGSNGEGESGLEYAYAGTAADNAAVEDEDKYVKMAGASVEELMARMKAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCJ9</accession>
    <accession>A0A3S5H6W2</accession>
    <name>E9BCJ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_151600</name>
        <name evidence="12" type="ORF">LdCL_150021300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859683.1">
        <property type="nucleotide sequence ID" value="XM_003859635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCJ9"/>
    <dbReference type="GeneID" id="13392980"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150021300"/>
    <dbReference type="OMA" id="TTNLMMF"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="PhylomeDB" id="E9BCJ9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000003">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38821" checksum="29E9DF2382E68C6E" modified="2011-04-05" version="1">MSSRPLLDDAHLSRGVGIRFVSLVVPVTATMLAVVWSLSCLSPIYVNSQVPPLPVVVNENDAATAGEKFVYSLVAALIVVGCVVAATFATVLLYHFHLQFVLYGWLAFSAVSMFFMLLWIWLDLFCTYFQIPYNVISMGIFVWNFGVVGLIALFYYSHPTVTQVYLVIASILTAWSLTALPEWSTWSLLICIATYDILAVLWQQGPLHRLIKIAQERDEPIPGFVYSSAHSIVPITQPATASSARVPATAAESFMWTVQHATPFKLGLGDFIFYSLLVGRASFSGFVSWSFCMVSILAGMLGTLLSLLLFRNSLRALPALPCSIFLSTVVFVLCRLIVESLSSFTSHHLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFE8</accession>
    <accession>A0A3Q8IBZ0</accession>
    <name>E9BFE8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_211620</name>
        <name evidence="3" type="ORF">LdCL_210021800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860679.1">
        <property type="nucleotide sequence ID" value="XM_003860631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFE8"/>
    <dbReference type="GeneID" id="13386524"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1920"/>
    <dbReference type="OMA" id="SANRHYF"/>
    <dbReference type="OrthoDB" id="273705at2759"/>
    <dbReference type="PhylomeDB" id="E9BFE8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1049" mass="111431" checksum="8164041364839C05" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFS1</accession>
    <accession>A0A3S7WX47</accession>
    <name>E9BFS1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guide RNA associated protein, GAP2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_220520</name>
        <name evidence="2" type="ORF">LdCL_220011500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860802.1">
        <property type="nucleotide sequence ID" value="XM_003860754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFS1"/>
    <dbReference type="GeneID" id="13389367"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0850"/>
    <dbReference type="OMA" id="FPSNTEC"/>
    <dbReference type="OrthoDB" id="276578at2759"/>
    <dbReference type="PhylomeDB" id="E9BFS1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="CDD" id="cd23732">
        <property type="entry name" value="RESC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057320">
        <property type="entry name" value="RESC1_2_CYTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25477">
        <property type="entry name" value="RESC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RESC1/2 CYTH-like" evidence="1">
        <location>
            <begin position="169"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="500" mass="54607" checksum="332C3312BB3E1332" modified="2011-04-05" version="1">MQSVCGRLSLRSTRNRGTCHLTLAAAALCVSHRYQSSTGPTIGDTRASGPQVAFSSKTVKLKYEEVWQLWNEGNLFSLQVAQMRDFLADAGIAVDPTAKKAAVVRRMEEYLHSKDSAEQRGGAAAIAGAAQGVGKESEQSYGNWAGAGAMQPEKLLDLAQAGFYQGTANMVPKAFQLLTTGSCAEAVVSRVNTSTFPGFPANTECYTLSSSDATGALQTRYSKVLQWCLLNMNNLRMDGELTMEVGKLLLTPAAMRYGEAVVSAYTLQQRLQLTKPYTWIAAMPESAIPLVEAFLKERGFQPVSKNARLTYEGVIKRAKDKLEVVLNEQMKVEGVYGEWVDVQTAFCTSVEKPDCRILLRSRPAVSAQDRETYTRIPVIELADDDVSDVLPPENGQLVYLSENETRHFERLNDKGIAIAVRETKRQPLIVLRDEEEDPRLEYQISVTIPASAGSHSMDVRAVGLEVLALSDELSTLLKEPFNEAYGCAPALDTGSVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGY0</accession>
    <accession>A0A3S7WYF3</accession>
    <name>E9BGY0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_241170</name>
        <name evidence="2" type="ORF">LdCL_240016800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861208.1">
        <property type="nucleotide sequence ID" value="XM_003861160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGY0"/>
    <dbReference type="GeneID" id="13390893"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1380"/>
    <dbReference type="OMA" id="LCAEFDQ"/>
    <dbReference type="OrthoDB" id="271478at2759"/>
    <dbReference type="PhylomeDB" id="E9BGY0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730282" description="EF-hand domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45274" checksum="668730EB986C41A7" modified="2011-04-05" version="1">MTGSRMPGGTRRLLVSLSSCLFTPASTASITVTVLITECLFSSRPPPSPPPHLKGAWQLMKATVTRQLWSRGLRLPRVSSAVPANLSHWDGLPRTMTGAAASAAPAARARTTASLTSPFICLRRFFWNPFASGTRGSVSATRDSVQRLNAEQDASIAEKAHRDADLENEQLLGACLDLLDMCSGNAAGSAPSSALDELARDRIWELVDVLLHDHHRAPAEQFDLVYTALCMPAAQDHRQVQRSLLLVLRSVVPETLYRVFESVDLFVVRDDEQSLHQRDALMKFAHAQLGDLHVPDGLAEEEVLSVYVDDIKTAFPVLATCPAWQVVERDATTIALKSKLFALLGRLCAEFDQEKTGKVKLADLRSTAERVLGTDQASRLLEGAQVDKDGKIAYAQLVALLSRPPPKKRAPAEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHC9</accession>
    <accession>A0A3Q8IN51</accession>
    <name>E9BHC9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_250250</name>
        <name evidence="3" type="ORF">LdCL_250007600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861356.1">
        <property type="nucleotide sequence ID" value="XM_003861308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHC9"/>
    <dbReference type="GeneID" id="13391525"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250007600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0310"/>
    <dbReference type="OMA" id="KTVNYDV"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="PhylomeDB" id="E9BHC9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="96168" checksum="93F8BA833207D6DB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHX9</accession>
    <accession>A0A3Q8INN7</accession>
    <name>E9BHX9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_252250</name>
        <name evidence="2" type="ORF">LdCL_250028300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861555.1">
        <property type="nucleotide sequence ID" value="XM_003861507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHX9"/>
    <dbReference type="GeneID" id="13388801"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2720"/>
    <dbReference type="OMA" id="MSLRCGE"/>
    <dbReference type="OrthoDB" id="273282at2759"/>
    <dbReference type="PhylomeDB" id="E9BHX9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27241" checksum="1D67AACE31578065" modified="2011-04-05" version="1">MDVDQHIAATISEIDRTLRSIGIRDDYASIFSQSSIINSPPPLLTAAVVRANGAVQTSRSTRVSTGAQKSPATVSQGVQNSPQQRATSSQTEKGADAQECFDKVTSSVLCGNAILEEGLQALESSSDKMEALFSKLAKLEGRVNRAAKSFRLLRNIWNIQIIEKEEASARSALLNYESSARTEFMSLRCGELIALVAAFRKERVPSKASSELKRPAPTRVIANGNVVVETPGSSLNDLTELLDECWRVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9BI49</accession>
    <accession>A0A3Q8IDI5</accession>
    <name>E9BI49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat/Tetratricopeptide repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_260360</name>
        <name evidence="5" type="ORF">LdCL_260009100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861625.1">
        <property type="nucleotide sequence ID" value="XM_003861577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BI49"/>
    <dbReference type="GeneID" id="13388870"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0470"/>
    <dbReference type="OMA" id="EPDNGMW"/>
    <dbReference type="OrthoDB" id="532682at2759"/>
    <dbReference type="PhylomeDB" id="E9BI49"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="853" mass="92910" checksum="071D2425B0C17EEF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIA8</accession>
    <accession>A0A3S7WZS8</accession>
    <name>E9BIA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ion transport protein/Polycystin cation channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_260960</name>
        <name evidence="8" type="ORF">LdCL_260015200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861683.1">
        <property type="nucleotide sequence ID" value="XM_003861635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIA8"/>
    <dbReference type="GeneID" id="13388929"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260015200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1230"/>
    <dbReference type="OMA" id="RGLFMHY"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="PhylomeDB" id="E9BIA8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF22">
        <property type="entry name" value="POLYCYSTIN CATION CHANNEL PKD1_PKD2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="7">
        <location>
            <begin position="336"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="590" mass="64693" checksum="9F7F4E12D7AB532F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLM2</accession>
    <accession>A0A3S7X380</accession>
    <name>E9BLM2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_301290</name>
        <name evidence="4" type="ORF">LdCL_300018100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862842.1">
        <property type="nucleotide sequence ID" value="XM_003862794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLM2"/>
    <dbReference type="GeneID" id="13385549"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1670"/>
    <dbReference type="OMA" id="WGDNIGP"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="PhylomeDB" id="E9BLM2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="723" mass="78960" checksum="88FACA1F2DB74F27" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9BP53</accession>
    <accession>A0A3S7X5W7</accession>
    <name>E9BP53_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_323020</name>
        <name evidence="3" type="ORF">LdCL_320036200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863715.1">
        <property type="nucleotide sequence ID" value="XM_003863667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BP53"/>
    <dbReference type="GeneID" id="13391240"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320036200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3800"/>
    <dbReference type="OMA" id="GHAHTQC"/>
    <dbReference type="OrthoDB" id="267284at2759"/>
    <dbReference type="PhylomeDB" id="E9BP53"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="593" mass="62577" checksum="CF62955181602912" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPH1</accession>
    <accession>A0A3S5H7U9</accession>
    <name>E9BPH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_332320</name>
        <name evidence="1" type="ORF">LdCL_330030200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864057.1">
        <property type="nucleotide sequence ID" value="XM_003864009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPH1"/>
    <dbReference type="GeneID" id="13392453"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3360"/>
    <dbReference type="OMA" id="DMATSCA"/>
    <dbReference type="OrthoDB" id="267883at2759"/>
    <dbReference type="PhylomeDB" id="E9BPH1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="388" mass="39722" checksum="8BBD13EA0DB63DB0" modified="2011-04-05" version="1">MHASCGSLDGAAGRGRSMAVADALISRWSRRSGASLAWPSHLPGGSGGEPASSFTAEAVVGVLPSATDAGRHAVDGRTTSLQPVFNASAAPPSIEELFAEVDEDDTDTSAAVTDFLAEEKVPGELKDGRRHGAALLSRTDSYTFVASASPEVTRFDDTGKAARSPCTPASATVEAALLEALLQEQLSQDLNGSVDDTAEEDSDGLDEVAPRAADAHAIINASCALPQGQYRAPDLQRAAHMETAGGDADGEADVKADSIEDAVDDEESMESVLEEEAERMYRAALTNMTNGEDTAAQGKARHGLFGDYTFFSKEAVASAVETLSTSESADAAGATSAFAFSDGIADGASTSAVEFDDDAAREAEMESVGDVMATSGAAAVAAGKAQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQX8</accession>
    <accession>A0A3Q8IHI2</accession>
    <name>E9BQX8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_341790</name>
        <name evidence="2" type="ORF">LdCL_340025500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864339.1">
        <property type="nucleotide sequence ID" value="XM_003864291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQX8"/>
    <dbReference type="GeneID" id="13392748"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3080"/>
    <dbReference type="OMA" id="EHKFFEP"/>
    <dbReference type="OrthoDB" id="260004at2759"/>
    <dbReference type="PhylomeDB" id="E9BQX8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="416" mass="44181" checksum="5A07B1E39601B3C4" modified="2011-04-05" version="1">MHGISIRSATPPRRHNASLSAESELTVLTAGVSLAHEETCTRKVACTVFNRTPADGAPRCKSNSSLTTVAVLSADLSPRQRRCGTSFASSILAECDSPCGSPRVHLTRPFSSRGSFAKPVLCGSVPSTGAPSLKAADGALANRSSSGLHGVSPSLSVTLSEAEEDVTVTSAESVSATASVEPLATPGSIVLAANDARPSSSPSFTYFPSSGGGVPQESSASTSDKANAVGSVPAFRLSSVPGIRDGCGAIVNNNISTEHKFFEPLQLDAAGHLFSPLQRFSSAHTSQRASCVAALEPRAFDFGGAPVEHKDVTIACPLSNVHHGKLCEIVKQQLLLHACLVSIARERDEGEDLQRRGNFTLEKVQLQQQRRRCRCLLSIMWLLWSVFLRLPLRFLKRVLTTSVGELRKILLLTQES</sequence>
</entry>
<entry dataset="TrEMBL" created="1997-05-01" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>P90634</accession>
    <accession>E9BHY7</accession>
    <name>P90634_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GIM1</name>
        <name evidence="25" type="ORF">CGC20_26175</name>
        <name evidence="24" type="ORF">CGC21_9140</name>
        <name evidence="23" type="ORF">LDBPK_252330</name>
        <name evidence="21" type="ORF">LdCL_250029100</name>
        <name evidence="22" type="ORF">LDHU3_25.2810</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="1997" name="Mol. Cell. Biol." volume="17" first="1093" last="1101">
            <title>Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes.</title>
            <authorList>
                <person name="Flaspohler J.A."/>
                <person name="Rickoll W.L."/>
                <person name="Beverley S.M."/>
                <person name="Parsons M."/>
            </authorList>
            <dbReference type="PubMed" id="9032236"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Ld4</strain>
        </source>
    </reference>
    <reference evidence="23 26" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21 27" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 27">LdCL</strain>
        </source>
    </reference>
    <reference evidence="29" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="28" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="24" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">FDAARGOS_360</strain>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="U80074">
        <property type="protein sequence ID" value="AAB48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861563.1">
        <property type="nucleotide sequence ID" value="XM_003861515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P90634"/>
    <dbReference type="GeneID" id="13388809"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2810"/>
    <dbReference type="OMA" id="WHGLMEL"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AAB48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU79570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAC5430810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CBZ34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP40830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TPP48816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="330" mass="38022" checksum="A46F0DCE821A554A" modified="1997-05-01" version="1">MAWLGDAVDAQYTIDTVSKQQALLPSSNAFSIFPKDHVLRIFQLDALVLQQELVEILQTTLFHVLDIPPLQHFRFAYQEELVLVLDALLYRLSVWRMGQSIGDRLQNLVLRDEERARLLALQNTKSILPSLAPSRRLLLVHAIMTLVMPYVTRKVQRKVLEEGWEREPVTTARHRIAKALRYGVVTWSLLSLANTFNFLMTGKYRTLVERILSLRLVYGSQRMMRFTNLLYMNQHVQWQTWMSLFRALSLGRYFRRLMKSLSSVASSSALLSMNENLCSACHELPTVCQRSNCGHRYCYYCIKSRLLDSQSTGSFRCIKCGQAVHSCAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6VXY9</accession>
    <accession>E9BBN1</accession>
    <name>Q6VXY9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CGC20_16900</name>
        <name evidence="24" type="ORF">CGC21_33640</name>
        <name evidence="23" type="ORF">LDBPK_131590</name>
        <name evidence="21" type="ORF">LdCL_130020000</name>
        <name evidence="22" type="ORF">LDHU3_13.1770</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="49965" last="49971">
            <title>Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance.</title>
            <authorList>
                <person name="Perez-Victoria F.J."/>
                <person name="Gamarro F."/>
                <person name="Ouellette M."/>
                <person name="Castanys S."/>
            </authorList>
            <dbReference type="PubMed" id="14514670"/>
            <dbReference type="DOI" id="10.1074/jbc.M308352200"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23 26" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21 27" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 27">LdCL</strain>
        </source>
    </reference>
    <reference evidence="29" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="28" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="24" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">FDAARGOS_360</strain>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="AY321297">
        <property type="protein sequence ID" value="AAQ82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812633">
        <property type="protein sequence ID" value="CAC5428520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000039">
        <property type="protein sequence ID" value="TPP50033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859368.1">
        <property type="nucleotide sequence ID" value="XM_003859320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6VXY9"/>
    <dbReference type="SMR" id="Q6VXY9"/>
    <dbReference type="TCDB" id="3.A.3.8.3">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="13390795"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1770"/>
    <dbReference type="OMA" id="KMYYSRS"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000223">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000203">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="831"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AAQ82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU77224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAC5428520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CBZ32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TPP50033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="1097" mass="124113" checksum="11043054BECAA9D3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I7Q1</accession>
    <name>A0A3Q8I7Q1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIF1-like helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_100011700</name>
        <name evidence="3" type="ORF">LdCL_100011900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I7Q1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100011900"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="293" mass="32044" checksum="92A69C733AB37CE3" modified="2019-04-10" version="1">MRDGVHRFGPRGLARCVDCVEGETTVQCADTHTIQGTLSFTARAPSQPPSLCRRCPRRCGSACSPVRRSRHHASRRSDPAQTPPTATATTTTPHTHGHTQRRPRRRPLSCPLCCAAPLRVVVWLTAVSVRRRTGRAKRLARGRAAAAAAPLRLACRIVWGGPLSTGPSWGRCGLSWEDGRARGLRWAPLSLRLACWPRSVSRGQPCCVSAPLPSSCELRTRQEATVAKGARVARAHTPSLLPWCPLAFLGPLHAACLPRSQRGEVLCEGRTAGAPTKTAQKTRCCARWRCRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9Y0</accession>
    <name>A0A3Q8I9Y0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinesin K39, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_140017700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1500"/>
    <dbReference type="OrthoDB" id="267991at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000042">
        <property type="entry name" value="Kinesin family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="40"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="466"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="766"/>
            <end position="3278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3402" mass="381680" checksum="0B3806969BA263D8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IA78</accession>
    <accession>E9BCK9</accession>
    <name>A0A3Q8IA78_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2OG-Fe(II) oxygenase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase (PhyH)/2OG-Fe(II) oxygenase superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_25330</name>
        <name evidence="8" type="ORF">LDBPK_160050</name>
        <name evidence="7" type="ORF">LdCL_160005400</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859693.1">
        <property type="nucleotide sequence ID" value="XM_003859645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IA78"/>
    <dbReference type="GeneID" id="13393061"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0050"/>
    <dbReference type="OMA" id="GHFMPHV"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000037">
        <property type="entry name" value="Phytanoyl-CoA_dioxygenase_(PhyH)/2OG-Fe(II )_oxygenase_superfamily_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="42"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="317" mass="35815" checksum="A48FF5A67EDA18BC" modified="2019-04-10" version="1">MFSYNNIIEKGEPLNKEIIDHVFDHVTEFPTPAMVSVGDGKADCIVLENFLTHEECDQLVAACEKVGYTFWLQKNHHDADGEATCDSASKAVRVVDTIEANFPHLSAKLYERIARVVSLKPKFFSEDMPNAEEFFERELAGTWVPHALSENLLFGRYHPGGHFMPHVDGSTILDLNTRSFYTLLIYLNDCLHGGETFIFAGEQCNVMYLDEKENQYRGNATQRVGAVYPKKGSAAFFYYNLLHEGAPVLQGHKYICRADLLYHRTPAIFTSEADVKAFNAYQEARLAESHGDAELACQLFQRVRKLSKGVASIFQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAS4</accession>
    <accession>E9BF29</accession>
    <name>A0A3Q8IAS4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_33925</name>
        <name evidence="5" type="ORF">LDBPK_210440</name>
        <name evidence="3" type="ORF">LdCL_210009200</name>
        <name evidence="4" type="ORF">LDHU3_21.0460</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860561.1">
        <property type="nucleotide sequence ID" value="XM_003860513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAS4"/>
    <dbReference type="SMR" id="A0A3Q8IAS4"/>
    <dbReference type="GeneID" id="13386389"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0460"/>
    <dbReference type="OMA" id="TTYISCP"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="215" mass="24742" checksum="3E33B8E4DAB0DD3A" modified="2019-04-10" version="1">MFHNSYQAGFLSILYSIGSKPLQIWDSQVRNGHVKRITDEDIQSSVLEIMGSNVSTCYIVCPANPKQTLGIKLPFLVMIIKNMKKYFSFEVTILDDKNMRRRFRASNYQSTTKVKPFICTMPMRLDEGWNQIQFNLSDFTRRAYGTNYVETLRVQVHANCRIRRLYFSDRLYAEEELPPEFKLFLPIAQQPPAAAAAEQRDVEAADVPQASSVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAX2</accession>
    <accession>E9BA41</accession>
    <name>A0A3Q8IAX2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymine dioxygenase JBP1</fullName>
            <ecNumber evidence="4">1.14.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">J-binding protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Thymidine hydroxylase JBP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CGC21_36615</name>
        <name evidence="20" type="ORF">LDBPK_091560</name>
        <name evidence="19" type="ORF">LdCL_090022000</name>
    </gene>
    <organism evidence="19 23">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19 23" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 23">LdCL</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:10316"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16964"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.14.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer. Binds to DNA as a monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TET family. JBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.6" evidence="4"/>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858833.1">
        <property type="nucleotide sequence ID" value="XM_003858785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAX2"/>
    <dbReference type="GeneID" id="13392174"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1830"/>
    <dbReference type="OMA" id="LCEVGKQ"/>
    <dbReference type="OrthoDB" id="275889at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050341">
        <property type="term" value="F:thymine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070580">
        <property type="term" value="P:base J metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20332">
        <property type="entry name" value="JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1440:FF:000001">
        <property type="entry name" value="Thymine dioxygenase JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.30:FF:000002">
        <property type="entry name" value="Thymine dioxygenase JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1440">
        <property type="entry name" value="JBP1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041241">
        <property type="entry name" value="DB_JBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043111">
        <property type="entry name" value="DB_JBP1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18526">
        <property type="entry name" value="DB_JBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="17">
        <location>
            <begin position="107"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thymine dioxygenase JBP1 DNA-binding" evidence="18">
        <location>
            <begin position="396"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CBZ32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP41638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="814" mass="91852" checksum="5E5B1FC04A607DCF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB10</accession>
    <accession>E9BF10</accession>
    <name>A0A3Q8IB10_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_22755</name>
        <name evidence="5" type="ORF">CGC21_33830</name>
        <name evidence="4" type="ORF">LDBPK_210250</name>
        <name evidence="2" type="ORF">LdCL_210007300</name>
        <name evidence="3" type="ORF">LDHU3_21.0250</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860542.1">
        <property type="nucleotide sequence ID" value="XM_003860494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB10"/>
    <dbReference type="GeneID" id="13386347"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0250"/>
    <dbReference type="OMA" id="EDYWLAV"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="724" mass="78554" checksum="2EF92B3A677CA4F1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC81</accession>
    <name>A0A3Q8IC81_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">A2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220012200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC81"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220012200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1110"/>
    <dbReference type="OrthoDB" id="6258998at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018690508" description="A2 protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="60435" checksum="2A5856EA5B56DE3F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICE3</accession>
    <name>A0A3Q8ICE3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_150020900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICE3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1880"/>
    <dbReference type="OrthoDB" id="242733at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="666" mass="73508" checksum="3525700984A67A47" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICH4</accession>
    <accession>E9BG89</accession>
    <name>A0A3Q8ICH4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4 6">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_18260</name>
        <name evidence="6" type="ORF">CGC21_17365</name>
        <name evidence="5" type="ORF">LDBPK_230690</name>
        <name evidence="4" type="ORF">LdCL_230013500</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860970.1">
        <property type="nucleotide sequence ID" value="XM_003860922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICH4"/>
    <dbReference type="SMR" id="A0A3Q8ICH4"/>
    <dbReference type="GeneID" id="13389931"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0970"/>
    <dbReference type="OMA" id="WVDAFPR"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42773:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42773">
        <property type="entry name" value="METALLO-BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599593" evidence="2">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP51360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="380" mass="42707" checksum="B98567C5A8060276" modified="2019-04-10" version="1">MLVLCRPLLLLHRGGGALRPTDLVRCTFQPNLTSLTNQVNRNEHFLKFGNKNIPMGVPRVSRRDVRPISILHETPHLLVAGRNYANGFAGNQFLLVQKERKECIFVDAADDWPDDWVSFIATSGLRPTHFFLTHCHVDCIVNLNAFLAVMEHHFHVRLGLMWCPAEQSWVDVFPRACERYGRIEEMRQPLPMLQNSLYSHYTYAHQLGQRQRVLNEAAAATEGGEDGADTVAGGRGSSSPRAPPRQLVRSSDILLSSATNRSTSFYDFGPHSVLHYVFTPGHSPGHMMLALPRERLLFTGDVLFYNAVGRVDLPWGSGERLAESLLTLEGYPDNTVLLPGHGRLTTLGRERRENRALRALYERRAAGDQQVSVGYNTGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDN9</accession>
    <accession>E9BI79</accession>
    <name>A0A3Q8IDN9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Qc-SNARE protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Qc-SNARE_protein_putative/GeneDB:LmjF.26.0690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_260660</name>
        <name evidence="9" type="ORF">LdCL_260012300</name>
        <name evidence="10" type="ORF">LDHU3_26.0870</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861654.1">
        <property type="nucleotide sequence ID" value="XM_003861606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDN9"/>
    <dbReference type="SMR" id="A0A3Q8IDN9"/>
    <dbReference type="GeneID" id="13388900"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0870"/>
    <dbReference type="OMA" id="EHDPYRF"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5430904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27879" checksum="D6992C0BACB95746" modified="2019-04-10" version="1">MNPASHSQGGAAVPPTVTATAAGSTREDPWPQMEKQVGGMLADLNAQMQRFRDTAMPTVIAENELLEAVGGCSEAVEDMRFALDTAMEHPESFAITAEELQSRAERIRGWERDMMKAQQVAEKVKAAQRKRIMAQDGDIGDGGVRENSDFLRQEHDIQLSMMQQDDQTLDRLSSGIHRVKDTAVNIQDELNTQEHILDDIDRGMTRVQMRLEGAMRKVSKLIDSTSDRGKMICIAVLFLILVILILFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDV8</accession>
    <name>A0A3Q8IDV8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-8 sterol isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_290028600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDV8"/>
    <dbReference type="SMR" id="A0A3Q8IDV8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3330"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018528801" evidence="8">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24928" checksum="067E09520B2B5949" modified="2019-04-10" version="1">MASFKCTSLLLISVVAVVIAFFAYVDQPSHWVYDPVRLQQIAQQSIATAHAANGGKATAKQVTDETIRLILENYPKTTRYTGHWLWNNAGGAMGSMTVLHCSFSEYLIIFGSSVGTEGHTGRYFWADDFFNILVGEQWAALPGVEEKEVYRPGDQHILPRGSAKQYRMPEECWALEYARGNIVSMLFFGFADMFSSTLDVVTIYQTVMESAGNMIRNILMGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE15</accession>
    <name>A0A3Q8IE15_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_210022900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE15"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2020"/>
    <dbReference type="OrthoDB" id="271828at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29737" checksum="32336FF1684D1E49" modified="2019-04-10" version="1">MAKWNALSEEIEAARASGDHTKLLEHVQVGLQMLKEIGATNAPIQCESLLCMEASQAHYKMGQYDEALRCAEKARESLLRDCKAKLQDKAQIAEIEVFMGFVLCKQGGHGAAVEAQELLQKVLRWIDVDAKSAMPMQAVAAVNLRRSVLTGLGLSTTVQATTLASKGETAEAKVLYAKGLDTLIEALNQHIDENDFELVKMTLEAILASFEGLDDVSQAVATCRKYISWCRRHDDASGVADGEAMLTALCARQKIENPLETEKAKEAEEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE19</accession>
    <name>A0A3Q8IE19_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial import receptor subunit ATOM69, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Mitochondrial_import_receptor_subunit_ATOM69_puta tive/GeneDB:LmjF.28.2170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_280028300</name>
        <name evidence="5" type="ORF">LDHU3_28.3150</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE19"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3150"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001400">
        <property type="entry name" value="Mitochondrial import receptor subunit ATOM69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5431615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="651" mass="71158" checksum="9FFEF35F71C9C470" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE47</accession>
    <accession>E9BJZ4</accession>
    <name>A0A3Q8IE47_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetratricopeptide repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_22775</name>
        <name evidence="7" type="ORF">LDBPK_282740</name>
        <name evidence="6" type="ORF">LdCL_280032500</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862372.1">
        <property type="nucleotide sequence ID" value="XM_003862324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE47"/>
    <dbReference type="SMR" id="A0A3Q8IE47"/>
    <dbReference type="GeneID" id="13387108"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280032500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3720"/>
    <dbReference type="OMA" id="PLCITVY"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="875"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="875"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1003" mass="108153" checksum="941FC4C17F8D47E4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEC6</accession>
    <accession>E9BJ39</accession>
    <name>A0A3Q8IEC6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_30880</name>
        <name evidence="3" type="ORF">LDBPK_271050</name>
        <name evidence="2" type="ORF">LdCL_270017000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861960.1">
        <property type="nucleotide sequence ID" value="XM_003861912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEC6"/>
    <dbReference type="GeneID" id="13389222"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1670"/>
    <dbReference type="OMA" id="NPNWRNI"/>
    <dbReference type="OrthoDB" id="278408at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="241" mass="26143" checksum="E6CBFFF30CD9E98D" modified="2019-04-10" version="1">MSGAGRKHRAKHLTQQYLDASGWAGPKEGERLAICMESPHGQHVRVLLLAPPNSAPASLSTETPTPGGSSSSDAPHGAEESEAVVSAAPLLEVEQVVHLPRKFHKVIWLSIKDVVVIADGTVSSKPSPEQVENFLKDPRNKGWRERVATAQHRAEDQRAVLQRMPHYAATAQTTTSVLTGPQVRSGVRATANGASEQDGEGSESEADDVCNPNWRNIKHQQQFFYGLGDDSDEEVEEEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEM1</accession>
    <accession>E9BGF4</accession>
    <name>A0A3Q8IEM1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC21_17025</name>
        <name evidence="10" type="ORF">LDBPK_231400</name>
        <name evidence="9" type="ORF">LdCL_230021100</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861033.1">
        <property type="nucleotide sequence ID" value="XM_003860985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEM1"/>
    <dbReference type="SMR" id="A0A3Q8IEM1"/>
    <dbReference type="GeneID" id="13390233"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1880"/>
    <dbReference type="OMA" id="NFQDDIY"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001430">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="510" mass="56202" checksum="824A987168FB46E3" modified="2019-04-10" version="1">MSVSRFRHSTGHVAKPQRHLLNVTSSTALWDGSNTISCNDKFIAVPWQTFGGTAVFKHDTFGRLAPNPPLVLGQKGQIIDVKFDPFNNHKLFTASEDGSIFGWGIPAEGLQSNISSPLVELKGHNKKCGIISFHPSANGVLASAGVDRVINVWDVERGTAVNTISNLSDYATGLEWNLRGSLFCIASRDKTLRVIDPRDCTVVSSVESHASARSQRCIWCKRKDTIMTLGCSKSQQRQIKLWDTRKMERPYSVTELDQSSAAFIPVYDEDLNLLILGSKGENNVKCFELMNEGLTFSYEVNSNDPMKGLCMMPKWSLDVRKCEFSRLYQLTYHSLFTIEMLLPRKQSCTEFQGDVFPSTFADHSAISAGEFFSGASADPREYDLSGLFDGHSPRLMGGSTPSPAKIPVAAQAAKPLKEAPKGETAAGREKSSVSVPASSEATSAQGDNGPAKHADPCADMTQREIFDKQRRLQELSEKVRTCHQEISALRKALQEKEAEMLQALEDIQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IET6</accession>
    <accession>E9BRQ6</accession>
    <name>A0A3Q8IET6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">60S_ribosomal_protein_L30/GeneDB:LmjF.35.0240</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_0820</name>
        <name evidence="8" type="ORF">CGC21_5735</name>
        <name evidence="7" type="ORF">LDBPK_350240</name>
        <name evidence="5" type="ORF">LdCL_350007400</name>
        <name evidence="6" type="ORF">LDHU3_35.0330</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="15" key="5">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="13223" last="13223">
            <title>Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.</title>
            <authorList>
                <person name="Zhang X."/>
                <person name="Lai M."/>
                <person name="Chang W."/>
                <person name="Yu I."/>
                <person name="Ding K."/>
                <person name="Mrazek J."/>
                <person name="Ng H.L."/>
                <person name="Yang O.O."/>
                <person name="Maslov D.A."/>
                <person name="Zhou Z.H."/>
            </authorList>
            <dbReference type="PubMed" id="27752045"/>
            <dbReference type="DOI" id="10.1038/ncomms13223"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="16" key="6">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.50 ANGSTROMS) OF 9-100</scope>
    </reference>
    <reference evidence="5 11" key="7">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="10">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="11">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864617.1">
        <property type="nucleotide sequence ID" value="XM_003864569.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="d=1-104"/>
    </dbReference>
    <dbReference type="PDB" id="5T2A">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="e=1-104"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ3">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="d=9-100"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="5T2A"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IET6"/>
    <dbReference type="EMDB" id="EMD-7025"/>
    <dbReference type="SMR" id="A0A3Q8IET6"/>
    <dbReference type="GeneID" id="13387495"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0330"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU82824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="5T2A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="6AZ3"/>
        </source>
    </evidence>
    <sequence length="104" mass="11382" checksum="C8A4CC12314AE972" modified="2019-04-10" version="1">MAKKTKSKVDTINAKLQLVMKSGKYVLGTQQALTTLRQGRSKLIVISNNCPPIRRAEVEYYCTLSKTPIHHYSGNNLDLGTACGKHFRTCVLSVTNVGDSDIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFP0</accession>
    <name>A0A3Q8IFP0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320037400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFP0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320037400"/>
    <dbReference type="OrthoDB" id="258431at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018615485" evidence="1">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="198" mass="22432" checksum="BB2D4E4E46AA495B" modified="2019-04-10" version="1">MNLFGTLAVTLCAIFVLIILPDEDSVEPVHDLLLNYQKEALKSRYGDARSLNHSETRRIYNSVLSEVQKAIFNLHEDADRKAYTCSRIRSQARQYARSRDGTYKGPLLEIALQLRDGYVHGVKYLHVALQKDLSYSLALQRPTLLHTAMVVRQTYYCLAPTLSGGECPSYAFLRVIRDKSDTEILESCVRSNKGFNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFU6</accession>
    <name>A0A3Q8IFU6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_320017500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFU6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320017500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1530"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="141"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="242"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="337" mass="37546" checksum="A4592958ED8EB48F" modified="2019-04-10" version="1">MAEKQSAAPKATALQHTVASQLGGAASTILLYPVDVIRIRFTSQDGTHTREHNGQTYRSILKAFQLIYRLEGGLPVFFRGCHVSVCGTVCAWGVYMYLYRCQCTWYEAWQAKRREAHCSGSGGSRFSETESLAACWAATWQNLLERFGFSIIASCTSAVACNPIWLLKTRMQLEEASARTAEVPRNFRTFRGGLLHTVQTTGARSLWRGVSAQMVLAVPNAFTLPLYDTVKAAAIGFRKGELSVLDVCVCSTVTKVVLALICQPVIVVKTRLQDHRARTGEIQYRSFLQSIRTIWKRGGLAAFYRGSVPSMCQTVPRSVLMFVFYEHFLKAAQHILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFY2</accession>
    <name>A0A3Q8IFY2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal region of Chorein, a TM vesicle-mediated sorter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360020500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1930"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF144">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1822"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2081"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3264"/>
            <end position="3289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3690"/>
            <end position="3710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4250"/>
            <end position="4270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4957"/>
            <end position="4981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5510"/>
            <end position="5530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2088"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2099"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3270"/>
            <end position="3286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4259"/>
            <end position="4270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4960"/>
            <end position="4971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="5603" mass="600998" checksum="CBBF1F1E581E3DDA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGG1</accession>
    <accession>E9BN87</accession>
    <name>A0A3Q8IGG1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative_cyclase_putative/Pfam:PF04199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_313170</name>
        <name evidence="2" type="ORF">LdCL_310040000</name>
        <name evidence="3" type="ORF">LDHU3_31.5380</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863401.1">
        <property type="nucleotide sequence ID" value="XM_003863353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGG1"/>
    <dbReference type="SMR" id="A0A3Q8IGG1"/>
    <dbReference type="GeneID" id="13389973"/>
    <dbReference type="KEGG" id="ldo:LDBPK_313170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310040000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5380"/>
    <dbReference type="OMA" id="YDGMPVY"/>
    <dbReference type="OrthoDB" id="7108654at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.50:FF:000007">
        <property type="entry name" value="Cyclase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18946" checksum="D1715653FE4F4C0E" modified="2019-04-10" version="1">MRLVDLSLPLYDGMPAYDGDPPVRVTKVCTREKDGWEVRHLQMGSHTGTHVDAPAHMHEDGSNLDEVPLTRFCGPAVVVKVADSSFPPNKGLLFYEAVPAECVPRIVAANAPFVGGPLEEETERLLLSRGIITYTDLVNVDQLIGESFTFYGLPLRIRGGDGSPVRAVAVMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGR9</accession>
    <accession>E9BNG0</accession>
    <name>A0A3Q8IGR9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_33590</name>
        <name evidence="4" type="ORF">CGC21_19835</name>
        <name evidence="3" type="ORF">LDBPK_320560</name>
        <name evidence="1" type="ORF">LdCL_320011100</name>
        <name evidence="2" type="ORF">LDHU3_32.0710</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863474.1">
        <property type="nucleotide sequence ID" value="XM_003863426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGR9"/>
    <dbReference type="GeneID" id="13390286"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0710"/>
    <dbReference type="OMA" id="PFTQIRA"/>
    <dbReference type="OrthoDB" id="269211at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="145" mass="16936" checksum="54DD3EF5DB2B70BA" modified="2019-04-10" version="1">MLVRSITKCVVPLIKATSYTSSYIVEHPPTPVRLTFMLPLHNKSMPTPLLDPERLQEISCGTGQPAQRGRRKPLVWKRRKPWFDHQWSLDLQRIKKGPETPHFPDGTPFTQIRSFQSFAGRSWKINAGRRRKIRLSLKRGRRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH99</accession>
    <name>A0A3Q8IH99_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360031300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH99"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360031300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3400"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37545" checksum="09C6B250B5D0F756" modified="2019-04-10" version="1">MLSESEHHLVAVAFQSMDPNNTGMVALSEVEKRYFAHAHPRVKEGSMAPSAARDTLDYHFGVCAADHEGSITFDEFLAYHEKVADEAYDEHVGDVAAFTEKTIMGLWRLGDVLLPTGVRPAFPVTQAPTGFYAVTLMTLVWVERRQMDASPASAQQSSSSGGAAHDDLFVLRGIKDVVRPIFTRGDLPDELQGYFAYPEELSGMAIDYVAPRLSIQRWYDFTWEYSEGKYCGVEGIISTRVDLESLPAGLRQFVCEHATAVSRGTTWMQTRLMMNPMYKKTSSAYGCGVSEECRKIHHWKVKTFEGKQYGNQYQGLCGKYFSKLGAPLKSGAATGMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHH4</accession>
    <name>A0A3Q8IHH4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_360041900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360041900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4770"/>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="939"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="964"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1848"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1887"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1916"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1947"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2057"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2374"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="4">
        <location>
            <begin position="1847"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="3">
        <location>
            <begin position="2127"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1492"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2228"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2505"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2507"/>
            <end position="2518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2533" mass="275904" checksum="8AB3390D94514ED7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHJ7</accession>
    <name>A0A3Q8IHJ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeats (3 copies)/Ankyrin repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_330006400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHJ7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0170"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="408" mass="44635" checksum="F27FEC7474225AF9" modified="2019-04-10" version="1">MANAVEPPAGAPAPVYKLPQRDLFDLVATNDVASLLILVRGDNPFDVSPGMELIRYKMSVRRFANMACAENAYVVSNAVPQVETAQIPRIRDASGNSATHVAASLGFSCMVDILVTECGCAVDEYNASGLTPLHLAALHGHVDSARLLRDLGADPLNPTYCNPPSSAGRNRGFCGRTTLFLAHLKQQAAVVALLLPLYHEFIATTFRGKTATEVWKAAATGQDVKSLSLLLDVLECRCTVIGALPVSIDFDVEDALWEVLPAVLETILPSSRQMTLCQFFLFERLVHLGYVDETTVLGSSDTVLERVLSTAHVRAWRALIEHGLVQPHKCNLDAVHSSERGDASEAELRALIEEAKAYFSYQVAKKSYAEKGDSHRRRSTLLNRRSVWKQLQNDLKQLSLSPARCPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHT7</accession>
    <accession>E9BUN8</accession>
    <name>A0A3Q8IHT7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_14930</name>
        <name evidence="2" type="ORF">LDBPK_365300</name>
        <name evidence="1" type="ORF">LdCL_360060200</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865644.1">
        <property type="nucleotide sequence ID" value="XM_003865596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHT7"/>
    <dbReference type="GeneID" id="13388530"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360060200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7080"/>
    <dbReference type="OMA" id="CSCVCCP"/>
    <dbReference type="OrthoDB" id="269744at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="393" mass="43539" checksum="70654A3A7FC31EA5" modified="2019-04-10" version="1">MSFNLEKLNRGLTRLASVRQYPIAKKQYVAKQTKGRVFRVGVLHKKELTEAALLRNRRGFINAQLNTVAHAPSLYHWLFHRCGIPFAETQALAKSGRLKVNEVIVSSASDLESQLSWETFQQLDIQVCSSLPALQSSSSTGAHVREASRAAQGTWVPALKRALHRTYTFIYLHPGVSVSSEESDPRSFVHRMAPIVGADPTPLLGLNVLRPIGFFDGMKGIGIASNDVSMVRYWNNESLGNFGVYDVRFPRGTPLEVVQHAAKDVEATLQARVQPQLSTDVGVSCSCVCCPPPPPSRDTVANQLFSAIPLLTEERLLVTTPLLPYRAARRLQRSGAVISLVRNGPFVLPSSLVQEKLRPCNATDLALLFTFERRLKTNRMVLSLREFDVGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II41</accession>
    <name>A0A3Q8II41_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division control protein 48, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280020500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II41"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2030"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002738">
        <property type="entry name" value="Putative ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF159">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="447"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="770" mass="82896" checksum="0A98C5E0D1D0D4F9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIL0</accession>
    <name>A0A3Q8IIL0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310024300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310024300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2960"/>
    <dbReference type="OrthoDB" id="273226at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1438" mass="152674" checksum="F9F307E690E8EB03" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIQ9</accession>
    <name>A0A3Q8IIQ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_310032000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIQ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310032000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4260"/>
    <dbReference type="OrthoDB" id="265531at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="662"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="908" mass="99972" checksum="D648CD1B4132F236" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJC3</accession>
    <name>A0A3Q8IJC3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_170009300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0650"/>
    <dbReference type="OrthoDB" id="261706at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1735" mass="185284" checksum="4141506841BF6B21" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJL1</accession>
    <name>A0A3Q8IJL1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180005900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJL1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0110"/>
    <dbReference type="OrthoDB" id="277568at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="454" mass="49972" checksum="8DCE7276C96EE319" modified="2019-04-10" version="1">MSLLVCSEECSLAEFSQKHQLSPHTLWLPLRAALPSRAGVKSTVAVDPRTPIALLETATDTILLDKRAICVKLQVANAVRCEETTVVVDPAAVPAGCEVFVRWSRPGGKKLRANTLVLHYDVQNATDTLARSSVSRLKRSRVDDNDSSVGASSLAGSLQGKQSRLSLVQQSTEDLQRRLSAAVGALGGQLSPRSTQILQSTLASMRHRQTQPPLHFVMPSDATVLEAAGVTWARSNRRILSRVFRSATSEERSEASKYSDGSRQLRFYFIEDVLLRRTREWTAAAAAAARRHIDEDGTTGRGTPPEEEEELLLKDEVLADMNTFAERGFRIVFLEHYPVLHHGSRYTVEQTLAPVVRLCRKGCPNLTVTVVLSAMSCVTAAQKQGLELSLVLPQAGLLTFFISELNTSFLPDPKTAAVVGSSDRGSEFLNKLHVEFARNASLTYVDEKELRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJQ7</accession>
    <accession>E9BDT1</accession>
    <name>A0A3Q8IJQ7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain roadblock</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_39265</name>
        <name evidence="15" type="ORF">CGC21_3070</name>
        <name evidence="14" type="ORF">LDBPK_181010</name>
        <name evidence="12" type="ORF">LdCL_180015300</name>
        <name evidence="13" type="ORF">LDHU3_18.1270</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000019">
        <property type="protein sequence ID" value="TPP53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860114.1">
        <property type="nucleotide sequence ID" value="XM_003860066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJQ7"/>
    <dbReference type="SMR" id="A0A3Q8IJQ7"/>
    <dbReference type="GeneID" id="13385960"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1270"/>
    <dbReference type="OMA" id="NNSTIEY"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000009">
        <property type="entry name" value="Dynein light chain roadblock"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016561">
        <property type="entry name" value="DYNLRB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009998">
        <property type="entry name" value="DLC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="11">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU78029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5429317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP55252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="112" mass="12479" checksum="8C567F2121B0F614" modified="2019-04-10" version="1">MAAAGSGPDIEELVKRITSHRGVRGFLIINNEGIAIRHSFTEASRELAVQYAALFQPLAMSAKTVLQEIDSNNELQLIRLRSKKDEVIVAPDNKYMLIIIQDADMDKVEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJZ4</accession>
    <name>A0A3Q8IJZ4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_12980</name>
        <name evidence="2" type="ORF">LdCL_360018600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJZ4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360018600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1700"/>
    <dbReference type="OrthoDB" id="277659at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59793" checksum="DAF168FF4CB24639" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILR1</accession>
    <accession>E9BRR6</accession>
    <name>A0A3Q8ILR1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_5775</name>
        <name evidence="3" type="ORF">LDBPK_350340</name>
        <name evidence="2" type="ORF">LdCL_350008400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ37945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864627.1">
        <property type="nucleotide sequence ID" value="XM_003864579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILR1"/>
    <dbReference type="GeneID" id="13387505"/>
    <dbReference type="KEGG" id="ldo:LDBPK_350340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0440"/>
    <dbReference type="OMA" id="VEPMCIK"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="497" mass="53919" checksum="3CE36E4BF1AF56E5" modified="2019-04-10" version="1">MPTYFFRIPSLQVCTVSFFGGGTLVLGSGLWDLMRSRRNAVPVFNSTTVVKTEESARYPCEKIKGFDVVVRSFYVSVATDTDGHAPAPALSLLARFRRLSGLFSNETHRVDNADLTKTTAADQPVRLVVRDAKDSDGGADTRLIAAAHWPPGTSKYAALILEPTPRTSDDSSAALPAQSRSLLRQFADGATHQSLSRCNPRSTLLHMACESDPAYLGAPYLRVLLSAFLLLPATLSQLNVAVLGVGGGSLPLFLQQYFAPRLHRCDLVDVEPMCIKAAVEQLGMKELLNTVALRCEGGGVHYYLEDAVDYLSHRVGDADCRTGCPLQAGSGRSAGSGEGASAAPHHGTPVFHDAVQPTPAAARATSAKRQRQLDLLFVDLFVGSELDTTVTSHEFLCLCRGSLSPHGVAAFNLPAADKRFVQRCNEVFGSRNVYRIPVPASSNEVVLARGGPKNSGAVADAPHLSHRLLFRRAQELSAHYRLPYDLANHYPVWWRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMG5</accession>
    <name>A0A3Q8IMG5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_330028600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMG5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3140"/>
    <dbReference type="OrthoDB" id="270884at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="86636" checksum="732E201E330751B1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPP9</accession>
    <name>A0A3Q8IPP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex protein 158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_270008700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0470"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000009">
        <property type="entry name" value="Nucleoporin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S59" evidence="2">
        <location>
            <begin position="757"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1574" mass="161318" checksum="E11B06850F9E617E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPS2</accession>
    <name>A0A3Q8IPS2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_350037200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350037200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4230"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1585"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1275"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1434"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1443"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1877" mass="202947" checksum="CC2DF746D8347B52" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISL3</accession>
    <name>A0A3Q8ISL3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_310020300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2200"/>
    <dbReference type="OrthoDB" id="265504at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000223">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF863">
        <property type="entry name" value="PPM-TYPE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="1914"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1260"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1467"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1740"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1878"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2021"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2141"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2454"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1270"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1303"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1467"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1751"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1878"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2044"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2151"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2163"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2454"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2478"/>
            <end position="2496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2565" mass="267882" checksum="3630FC5D4C75A14F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IW45</accession>
    <accession>E9BU22</accession>
    <name>A0A3Q8IW45_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain factor 2 protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Bromodomain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Bromodomain_factor_2_protein_putative/GeneDB:LmjF.36.2980</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_28410</name>
        <name evidence="9" type="ORF">CGC21_13850</name>
        <name evidence="7" type="ORF">LDBPK_363130</name>
        <name evidence="5" type="ORF">LdCL_360037800</name>
        <name evidence="6" type="ORF">LDHU3_36.4330</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2015-06" db="PDB data bank">
            <title>Crystal Structure Analysis of bromodomain from Leishmania donovani complexed with bromosporine.</title>
            <authorList>
                <person name="Jiang D.Q."/>
                <person name="Tempel W."/>
                <person name="Loppnau P."/>
                <person name="Graslund S."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Bountra C."/>
                <person name="Hui R."/>
                <person name="Amani M."/>
                <person name="Hou C.F.D."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 1-125</scope>
    </reference>
    <reference evidence="5 11" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865428.1">
        <property type="nucleotide sequence ID" value="XM_003865380.1"/>
    </dbReference>
    <dbReference type="PDB" id="5C4Q">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.93 A"/>
        <property type="chains" value="A/B=1-125"/>
    </dbReference>
    <dbReference type="PDBsum" id="5C4Q"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IW45"/>
    <dbReference type="SMR" id="A0A3Q8IW45"/>
    <dbReference type="GeneID" id="13388314"/>
    <dbReference type="KEGG" id="ldo:LDBPK_363130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360037800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4330"/>
    <dbReference type="OMA" id="LHKEQCL"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5434886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5C4Q"/>
        </source>
    </evidence>
    <sequence length="236" mass="26770" checksum="5499C99FCDF13887" modified="2019-04-10" version="1">MDVSKRPREEFHKEQCLSFVKKLWAADTLAMFHYPVSATEVPGYYDVVDTPMDLSTIRKNIEQGKYRTDTEVENDVVLMLSNALDFNEKGSQWHDLAKQLKKRYLTLAQESGLSFDADQAFIPTKKVRDDESTLRKAEKKGGEKLEDVLQAMEKDKEIPLEQLRAMYARRRTRGKADQQSSDYSSGRGSDDSDEEVSSDEEDTSDSGSGSGSYDTEEEDEDSLDSESVSKDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F5</accession>
    <name>A0A3S5H5F5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paraflagellar rod component par4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050005300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0070"/>
    <dbReference type="OrthoDB" id="250119at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="581" mass="68516" checksum="0901468E442B47FF" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6I0</accession>
    <accession>E9BAL2</accession>
    <name>A0A3S5H6I0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_30705</name>
        <name evidence="8" type="ORF">LDBPK_110240</name>
        <name evidence="6" type="ORF">LdCL_110007300</name>
        <name evidence="7" type="ORF">LDHU3_11.0300</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859002.1">
        <property type="nucleotide sequence ID" value="XM_003858954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6I0"/>
    <dbReference type="SMR" id="A0A3S5H6I0"/>
    <dbReference type="MEROPS" id="T01.974"/>
    <dbReference type="GeneID" id="13389508"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110240"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0300"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="247" mass="27819" checksum="128178CCDBB63DEA" modified="2019-04-10" version="1">MSYDRAITVFSPDGHLFQVEYAQEAVKKGLAAVGVLGSDCVVIAVEKKSAVKLQDSRTIRKIYKVDAHIYLAFAGLSADARVLINKAQLECQRFSLNYEDTIDVDMLVRYVAGVQQKSTQSGGSRPFGVATVIGGFNEDGKPHLWKTDPSGMCSAWRAVAIGRHDQTVIEYMEKNYKDGMSRDECVHFAIKSLLEVVESGSRNIELLVLQYKEERYLTEEELQKFVVEVEKEREEEAAKKKRQAEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6M8</accession>
    <name>A0A3S5H6M8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_130005600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6M8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0080"/>
    <dbReference type="OrthoDB" id="272969at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF9">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="556" mass="61344" checksum="6F907894D986F2AA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6V6</accession>
    <accession>E9BCF9</accession>
    <name>A0A3S5H6V6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endonuclease/Exonuclease/phosphatase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Inositol/phosphatidylinositol phosphatase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inositol/phosphatidylinositol_phosphatase_putativ e/GeneDB:LmjF.15.1210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_30415</name>
        <name evidence="9" type="ORF">CGC21_1390</name>
        <name evidence="8" type="ORF">LDBPK_151210</name>
        <name evidence="6" type="ORF">LdCL_150017600</name>
        <name evidence="7" type="ORF">LDHU3_15.1510</name>
    </gene>
    <organism evidence="6 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000037">
        <property type="protein sequence ID" value="TPP53187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859643.1">
        <property type="nucleotide sequence ID" value="XM_003859595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6V6"/>
    <dbReference type="GeneID" id="13393029"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1510"/>
    <dbReference type="OMA" id="VREDAWC"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000128">
        <property type="entry name" value="Inositol/phosphatidylinositol phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="587"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP47696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="792" mass="86182" checksum="5CF7B2CDE453F54D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6W5</accession>
    <name>A0A3S5H6W5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160006100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6W5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0130"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="462"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="826" mass="94676" checksum="C2E2F5CC7A65FDD3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H746</accession>
    <name>A0A3S5H746_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin, putative</fullName>
            <ecNumber evidence="9">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_180020500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="9"/>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H746"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1930"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000198">
        <property type="entry name" value="Putative kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="180"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="247"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1241" mass="133132" checksum="EF02CAFB527375DA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H789</accession>
    <name>A0A3S5H789_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_200018300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H789"/>
    <dbReference type="SMR" id="A0A3S5H789"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1710"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001824">
        <property type="entry name" value="Kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="59"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU78417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="384" mass="42334" checksum="D3182EC59C974012" modified="2019-04-10" version="1">MSTASQHRKSDSAERDEVNVKNAPKVASEAEINRRNVVFAEALRCACIAMRVGDDPGYIWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKEMRLSAVLEKVRCAGREVALCRRAGVSPHVVPMYEPWFDCREGVIALPMDAGDFSLEQYAVHCGFRFPPLVLLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTAGGAGAGGDGGRRDARAPLVRILDFGLACGVEEVGQELKRCVGTPHYMAPETFSHLCDCDVPAACDVWSLGVTLFRLATGVFPVFEMDKTWQQPPFTALHSGKLWLPSRNLFHEPLSAESLAVLSVAASMLVLDPRYRPTADAAVLQLQGFQEAFSHQIQSWPPGSGPQPCRVWKRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7N6</accession>
    <name>A0A3S5H7N6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300032700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7N6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302710.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300032700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3630"/>
    <dbReference type="OrthoDB" id="266332at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="932" mass="96657" checksum="17185A06C201E221" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ75</accession>
    <accession>E9B9F4</accession>
    <name>A0A3S7WQ75_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_080490</name>
        <name evidence="2" type="ORF">LdCL_080009800</name>
        <name evidence="3" type="ORF">LDHU3_08.0550</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858614.1">
        <property type="nucleotide sequence ID" value="XM_003858566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ75"/>
    <dbReference type="GeneID" id="13391978"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0550"/>
    <dbReference type="OMA" id="DYFTNHY"/>
    <dbReference type="OrthoDB" id="273155at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30239" checksum="6DD351F3146709FB" modified="2019-05-08" version="1">MAQLTRDEVHTYAEAMIAAIKTPAFQERVRAAMSREPTPTDAEAVMKRYEEVQADYFTNHYNAEAGGICSSVSAGAVGRGTGDACGRAKSSQDASGVLAQQVDNMSLEKASDAPKLDGVEIVEQLKNAVRMYKEKETVRLITELCLLIESQVTALPAAVPALKHLYSNSVYGSSAMEQAQAASARAGGGENVLPVAHPSPQVMQMMDMAMRTLSPKQRETLERVQRATMNGSPPLPEDMQDMLLIQRQLGAFMQTMQRFGQMPSGRGRGSGGRGGCGGRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQX1</accession>
    <accession>E9BA40</accession>
    <name>A0A3S7WQX1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_091550</name>
        <name evidence="3" type="ORF">LdCL_090021900</name>
        <name evidence="4" type="ORF">LDHU3_09.1820</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858832.1">
        <property type="nucleotide sequence ID" value="XM_003858784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQX1"/>
    <dbReference type="SMR" id="A0A3S7WQX1"/>
    <dbReference type="GeneID" id="13392173"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1820"/>
    <dbReference type="OMA" id="FFCQMGR"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13037" checksum="58C521D2F743621A" modified="2019-05-08" version="1">MQRLTYAAMKALVAKKLSGDLHMCILDVRNADEVAEGAIPASVHVPLDQLETALQLTADEFKKKYSAPKPEVSDHVVTYCLRGMRAERAAAALHSSGYTNVDVYPGSWAEWSEQEKCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSY1</accession>
    <accession>E9BBT8</accession>
    <name>A0A3S7WSY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_38675</name>
        <name evidence="4" type="ORF">LDBPK_140530</name>
        <name evidence="2" type="ORF">LdCL_140010700</name>
        <name evidence="3" type="ORF">LDHU3_14.0730</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000042">
        <property type="protein sequence ID" value="TPP53496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859424.1">
        <property type="nucleotide sequence ID" value="XM_003859376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSY1"/>
    <dbReference type="SMR" id="A0A3S7WSY1"/>
    <dbReference type="GeneID" id="13391411"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0730"/>
    <dbReference type="OMA" id="TPECARC"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="109" mass="11841" checksum="7E037614EE17C84F" modified="2019-05-08" version="1">MTRQADEQKSMRKVTGSGEAEKTSKLRTDDLAALQERMKKLHAEVTQQSEAKEQRARELAAVPVADEDVQVVAAALTVTPECARSLLQEKNGDVTAVLRDAVGLPKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTS3</accession>
    <name>A0A3S7WTS3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_160006200</name>
        <name evidence="2" type="ORF">LDHU3_16.0140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTS3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0140"/>
    <dbReference type="OrthoDB" id="245811at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd23018">
        <property type="entry name" value="mt-LAF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5428871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="786" mass="85336" checksum="FC2641CBB34AAC9B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUA9</accession>
    <accession>E9BD43</accession>
    <name>A0A3S7WUA9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_3780</name>
        <name evidence="4" type="ORF">LDBPK_170220</name>
        <name evidence="3" type="ORF">LdCL_170007700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859876.1">
        <property type="nucleotide sequence ID" value="XM_003859828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUA9"/>
    <dbReference type="GeneID" id="13393335"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0430"/>
    <dbReference type="OMA" id="QWETEHQ"/>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="526" mass="58420" checksum="DB80FBE84D7741C5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUM0</accession>
    <name>A0A3S7WUM0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_170019500</name>
        <name evidence="4" type="ORF">LDHU3_17.1850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1850"/>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5429187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1422" mass="160087" checksum="2E5F27C508620900" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVH9</accession>
    <accession>E9BE90</accession>
    <name>A0A3S7WVH9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-coumarate:coa ligase-like protein</fullName>
            <ecNumber evidence="6">6.2.1.12</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">4-coumarate:coa_ligase-like_protein/GeneDB:LmjF.1 9.0985/GeneDB:LmjF.19.0995/GeneDB:LmjF.19.1005</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">AMP-binding enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_8815</name>
        <name evidence="8" type="ORF">LDBPK_190970</name>
        <name evidence="6" type="ORF">LdCL_190015000</name>
        <name evidence="7" type="ORF">LDHU3_19.1200</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860273.1">
        <property type="nucleotide sequence ID" value="XM_003860225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVH9"/>
    <dbReference type="SMR" id="A0A3S7WVH9"/>
    <dbReference type="GeneID" id="13386085"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1200"/>
    <dbReference type="OMA" id="YIMPKFD"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016207">
        <property type="term" value="F:4-coumarate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="61"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="482"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5429491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP41778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="603" mass="66105" checksum="C22625410DCBD86D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVM1</accession>
    <accession>E9BEE8</accession>
    <name>A0A3S7WVM1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain, G-beta repeat family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_18815</name>
        <name evidence="7" type="ORF">LDBPK_191580</name>
        <name evidence="6" type="ORF">LdCL_190021600</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP50912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860331.1">
        <property type="nucleotide sequence ID" value="XM_003860283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVM1"/>
    <dbReference type="GeneID" id="13386142"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1920"/>
    <dbReference type="OMA" id="CLWKYNY"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001089">
        <property type="entry name" value="WD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="190"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP50912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="401" mass="43569" checksum="42F7DBAD31D73FCC" modified="2019-05-08" version="1">MLDSGSSSAEGGAKRFSRQQIIQHVKKSLLYTAFDVRWVPQTASFAVVGQYPNNHGALSVYQLHHGDVQPTVEVRLPHPLKCCTFGHNVSFSSSGGSSGGNTSNITAASATMNQIATGDFAGSLQIFDLSRLGSTPSRAPNALSDVTAASVLHIPHAHESIINAIDGARYSGPPEVATGSRDGSVKVWDTRQSNKPVVSLNPVDPARARDCWTVRLGNSFDPDERVVAAGYDNGDVKIFDLRTQKMLHEMHVNNGVCDLEFDRPDIPMNKLLVSSLEGRVRCYDMRTLHPKLGYAYVEERVSEGTVWCSRALPQNREIFLSGGGGELTLCLYKYPPERTLKDGDGLQRGVAGAVEQLNKAKIGDQPINAMDWNRSKEGLAVCASFDQSIRVMLVTKLSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWB2</accession>
    <name>A0A3S7WWB2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210008200</name>
        <name evidence="3" type="ORF">LDHU3_21.0360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWB2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0360"/>
    <dbReference type="OrthoDB" id="272484at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="544" mass="57083" checksum="DCBC7B90E0A62B70" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWW4</accession>
    <name>A0A3S7WWW4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_210028300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWW4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_081300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210028300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2660"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09992">
        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF4">
        <property type="entry name" value="DEACETYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="463"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="628" mass="66707" checksum="C799899772B9500B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX16</accession>
    <name>A0A3S7WX16_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220011100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX16"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0810"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="90"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="260" mass="28237" checksum="741DB5B5365A3F2C" modified="2019-05-08" version="1">MQAARLPTRIATGDGEDAPQPPPVHAPAPPAATDEQVTDQPQQAVGEATTPTDRAGFQPPSAEALAARQSRNSAGAEKMGGGQRLRDHTTAQRRLMQDYRTFQKHMAEGTSSNITALPVDGDFFHWHAVISGPCDTPWEGGLFKLDLIFGDDYPFSPPKVRFRTKDVFHPNVYADGNICMDTLKSSWQSSLNLEALLISIQSLLSDPNPLSAANGAAARLLTENRSAYDEKIRALVEESLEQSFSMDDDSDDAEVDEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXC1</accession>
    <name>A0A3S7WXC1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_220017700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220017700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1540"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_625, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45333">
        <property type="entry name" value="MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="802"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1633" mass="168346" checksum="0FFC2A6E7461FB2F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXK7</accession>
    <accession>E9BG31</accession>
    <name>A0A3S7WXK7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase/Methyltransferase small domain/Methyltransferase domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative_methyltransferase/Methyltransferase_smal l_domain/Methyltransferase_domain_containing_protein_putati ve/Pfam:PF10294/Pfam:PF05175/Pfam:PF13847/Pfam:PF08241/Pfam:PF08242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_17640</name>
        <name evidence="3" type="ORF">LDBPK_230110</name>
        <name evidence="1" type="ORF">LdCL_230006000</name>
        <name evidence="2" type="ORF">LDHU3_23.0130</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860912.1">
        <property type="nucleotide sequence ID" value="XM_003860864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXK7"/>
    <dbReference type="GeneID" id="13389873"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0130"/>
    <dbReference type="OMA" id="CRYAWVD"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="260" mass="28564" checksum="73C6E66362074D7B" modified="2019-05-08" version="1">MRTGGGQRNALAGACNDHKYANVEALRKLVRLDCRYAWVDVPFSTPSGRHQMLVRQRGATCGPSTPENVDLVALLNSDSIPQYIWPAAYPMCEWVHSHSDMFQGKCVLELGCGAGVLGFTVAQHARQVVLTDCSPVSLALVLESVARNGYRNCNVAVLQWGREDQLAQIKLECGVDSFDIVMGSDVFYFSSTLKAGLATARSALMPRHDNDAVFLCGSVARSDRMEVDLEEMPLQEGFVLADSIVVDPFRLYVWKVSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY31</accession>
    <accession>E9BGP6</accession>
    <name>A0A3S7WY31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_240340</name>
        <name evidence="3" type="ORF">LdCL_240008300</name>
        <name evidence="4" type="ORF">LDHU3_24.0400</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861124.1">
        <property type="nucleotide sequence ID" value="XM_003861076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY31"/>
    <dbReference type="GeneID" id="13390574"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240340"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240008300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0400"/>
    <dbReference type="OMA" id="VYAGMAH"/>
    <dbReference type="OrthoDB" id="270615at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="263" mass="29920" checksum="58D7538607BF8A57" modified="2019-05-08" version="1">MEAYIHTLRLRVRDAAHSCWTAAFPSDRPSAAYSIYTCIINSGLLVCSFAVVLSHPCETVAGLWVYAGMAHCFVNMIFGVLVVVLTRRQIAAGIPEETSQWLVCFSNPLIAVYSLYVVWEIVWMIAVVQFSDRNPHTVCSSHLNVQVAFFVLYLLVGFALFYSTFITERWRRPRWRRFAAMRYDYLHRTRSRYTVRWNDEDTSIGGDGQPGDLDRVRMSPLDGTERTTTLDYASIMDDSTTAAGDGRRDRDSRDARGCRRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY47</accession>
    <name>A0A3S7WY47_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-galactose transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_240008400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY47"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0420"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="557" mass="60807" checksum="DA630127B38699A1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZS4</accession>
    <accession>E9BID5</accession>
    <name>A0A3S7WZS4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_31955</name>
        <name evidence="5" type="ORF">LDBPK_261230</name>
        <name evidence="4" type="ORF">LdCL_260017900</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861710.1">
        <property type="nucleotide sequence ID" value="XM_003861662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZS4"/>
    <dbReference type="GeneID" id="13388956"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1530"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002779">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="2">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP41160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76668" checksum="46D609404F21E625" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0F1</accession>
    <accession>E9BIY0</accession>
    <name>A0A3S7X0F1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Brix domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA processing factor 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribosome production factor 1, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ribosome_production_factor_1_putative/GeneDB:LmjF.27.0450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_33155</name>
        <name evidence="7" type="ORF">CGC21_31245</name>
        <name evidence="5" type="ORF">LDBPK_270460</name>
        <name evidence="3" type="ORF">LdCL_270009400</name>
        <name evidence="4" type="ORF">LDHU3_27.0540</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861903.1">
        <property type="nucleotide sequence ID" value="XM_003861855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0F1"/>
    <dbReference type="GeneID" id="13389164"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0540"/>
    <dbReference type="OMA" id="AWIISNK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000006">
        <property type="entry name" value="RNA processing factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="125"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="330" mass="39328" checksum="5C80EACD25D50F0B" modified="2019-05-08" version="1">MGKGARSKRSTRPYAKRQHVLESKAQEVDPALLERYRNTQQPIRKSQLFTEILKQKKDTKRARRESRENERRHLKDKAPVKATPKTKERKRRADVTIIENKEDAEIINDEADDEFAAFFRDRKNPKTLITTGEHPCFRTKQLVKELLWLVPNSIYRPRKSYTLKEITLFCCNREFTDLLVVTDRIKEPYNLIVSHLPEGPTATFRVSNFLSYTQLEDPAPRTEHYPELIFKNFDTRLGRRISRMLECLFPATRDYAGRAVATFHNQRDYIFLRTHRYIFDGLEAVRLQEMGPRFTLRLLSLQSGTFDRQFGEYEWYRKKEHDADTLEWYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X102</accession>
    <accession>E9BJF1</accession>
    <name>A0A3S7X102_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA oxidase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Acyl-CoA oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_30330</name>
        <name evidence="6" type="ORF">LDBPK_272210</name>
        <name evidence="5" type="ORF">LdCL_270029500</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862072.1">
        <property type="nucleotide sequence ID" value="XM_003862024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X102"/>
    <dbReference type="GeneID" id="13386807"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270029500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3360"/>
    <dbReference type="OMA" id="GHIGIFL"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000042">
        <property type="entry name" value="Acyl-CoA oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000058">
        <property type="entry name" value="Putative acyl-CoA oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="4">
        <location>
            <begin position="523"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="719" mass="80765" checksum="FEAA1D3FB28EB34C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X191</accession>
    <accession>E9BKB2</accession>
    <name>A0A3S7X191_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">BTB/POZ domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BTB/POZ_domain_containing_protein_putative/Pfam:P F02214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_13725</name>
        <name evidence="7" type="ORF">CGC21_21890</name>
        <name evidence="5" type="ORF">LDBPK_280740</name>
        <name evidence="3" type="ORF">LdCL_280012000</name>
        <name evidence="4" type="ORF">LDHU3_28.0910</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862173.1">
        <property type="nucleotide sequence ID" value="XM_003862125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X191"/>
    <dbReference type="SMR" id="A0A3S7X191"/>
    <dbReference type="GeneID" id="13386909"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0910"/>
    <dbReference type="OMA" id="HTIVFRV"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000185">
        <property type="entry name" value="Btb/poz domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP40560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="475" mass="50049" checksum="27A0ECAF8C13F317" modified="2019-05-08" version="1">MPVTNGKRPREDSGAPVDEAAMRDTTRCALEAKDAAATPLDRVVVLNVGGTKITTLQSTLCSSPSLLAQWAENNFQEFPRDLQGHPFLDRDPENFVHILNYLRGYGLPNKADDLVVVAEDAELYQLESLKREIGLDPPSMWRFTPGPGIRDDGVEFSTSDILDLCGTEPLSTGLAHTIVFRIDKCELVSIGVVAFKEIQHDMQIRRQKNTVCYCNTGELVRYWSADALYEQGVLYKSQDEITVRVEFAQPGVPLEPPSGAKTMEHLPPPLQPALTLSSTPLPANVSSTTALGSSSVVPSRPLPLVIDASVAMANASSGAEPPITSPAFQPGSSAMDVANNRPLQQSSSSPMTTPANPTTLPSPQTLGGSGGGTAGTGTATTPTSGPSAAPASAPGVAPASPLLPFAPVVLDPEDPDATVGAIVTFFKGDREVCRARWPAPVPPLQFAVSMQGASAVSILKTTSVSADAVGMENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X192</accession>
    <accession>E9BK98</accession>
    <name>A0A3S7X192_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Leishmanolysin</fullName>
            <ecNumber evidence="5 19">3.4.24.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CGC21_21835</name>
        <name evidence="21" type="ORF">LDBPK_280600</name>
        <name evidence="20" type="ORF">LdCL_280010700</name>
    </gene>
    <organism evidence="20 24">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 23" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20 24" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 24">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="25" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an integral role during the infection of macrophages in the mammalian host.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.36" evidence="5 19"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862159.1">
        <property type="nucleotide sequence ID" value="XM_003862111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X192"/>
    <dbReference type="SMR" id="A0A3S7X192"/>
    <dbReference type="GeneID" id="13386895"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280010700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0770"/>
    <dbReference type="OMA" id="DSEEPRC"/>
    <dbReference type="OrthoDB" id="262619at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.170.20:FF:000005">
        <property type="entry name" value="MSP-A1 surface protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18 19" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 19 20" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044516129" description="Leishmanolysin" evidence="19">
        <location>
            <begin position="24"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYU80211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CBZ35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TPP54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="566" mass="60627" checksum="FA01470DC2CA74DA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1U3</accession>
    <name>A0A3S7X1U3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IQ calmodulin-binding motif containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280033200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280033200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3790"/>
    <dbReference type="OrthoDB" id="252964at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF2">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1754" mass="192833" checksum="DAFBB0713B51E53F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2M1</accession>
    <name>A0A3S7X2M1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290027700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2M1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3090"/>
    <dbReference type="OrthoDB" id="267580at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="745" mass="77417" checksum="407A85168D732219" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X350</accession>
    <accession>E9BLI1</accession>
    <name>A0A3S7X350_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_35220</name>
        <name evidence="14" type="ORF">LDBPK_300880</name>
        <name evidence="13" type="ORF">LdCL_300013900</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862801.1">
        <property type="nucleotide sequence ID" value="XM_003862753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X350"/>
    <dbReference type="GeneID" id="13385508"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1100"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000245">
        <property type="entry name" value="Methyltransferase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ36109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP45653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="250" mass="28202" checksum="C406DAFE3E73A35E" modified="2019-05-08" version="1">MPSKEASSRNLPISGRDTNGKTYRSTDEMWKAELTGDLYDPEKGWYGKALEYWRTVPATVSGVLGGMDHIHDVDIEGSRSFIESLPGHGTSRALDCGAGIGRIAKNLLTKLYAATDLLEPVEHMLEEAKRELAGMPVGKFILASMETTTLPPNTYDLIVIQWTAIYLTDDDFVKFFKHCQQALTPNGYIFFKENCSTGDRFLVDKEDSSLTRSDIHYKRLFNESGVRVVKEAFQEKWPTDLFPVKMYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3N8</accession>
    <accession>E9BM17</accession>
    <name>A0A3S7X3N8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small glutamine-rich tetratricopeptide repeat protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Small_glutamine-rich_tetratricopeptide_repeat_pro tein_putative/GeneDB:LmjF.30.2740</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TPR domain protein, conserved</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">TPR repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_6465</name>
        <name evidence="8" type="ORF">CGC21_36080</name>
        <name evidence="6" type="ORF">LDBPK_302740</name>
        <name evidence="4" type="ORF">LdCL_300033000</name>
        <name evidence="5" type="ORF">LDHU3_30.3660</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862985.1">
        <property type="nucleotide sequence ID" value="XM_003862937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3N8"/>
    <dbReference type="SMR" id="A0A3S7X3N8"/>
    <dbReference type="GeneID" id="13385694"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300033000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3660"/>
    <dbReference type="OMA" id="AAMRHMS"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000018">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000609">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF5">
        <property type="entry name" value="STI1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5432298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP45825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="408" mass="45815" checksum="C35F6297AC775681" modified="2019-05-08" version="1">MEERDLPITDDHRKLVFSFIRMIRRSQVENPERAEAVAQMLGEEFGVDPAGSGGLHDTEVDVLEAFKTALREHERRSGVEQDEKFVCFVELLEKKGYFKGVEKGSDEYAQRLEKAREKFNQRNNPYEGLTAEQIKNKGNELMSQAKYKEAIAYYTKAIELQPDNAVFFANRAAAHTHLKDYNNAIIDCERAIIINPEYSKSYSRLGTALFYQENYSRAVDAFTKACELDPDNATHKEDLKRAEEKAKATALSTGGGMGGFPGMGGFPEMGGMPDMSQFANMMSNPQFMETAQRMMQNPEFSNLVANMASKFSQGGMDPAELNRLGADMGMRNVDEEGNVVTPFGKVNRAAIEQLQEEEVRKNPKLAGIMADVQANGYGAFQKYLGDPDVMNLMMKFQNLMFTNPNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4J4</accession>
    <name>A0A3S7X4J4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Surface membrane protein gp46-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_310022000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4J4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2590"/>
    <dbReference type="OrthoDB" id="258940at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019538293" evidence="4">
        <location>
            <begin position="35"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33439" checksum="643E2DABE61FCF14" modified="2019-05-08" version="1">MMPVLLRRGVMQRPRAALLVVALTLCLLLSPVRGAESPFTHYSAVQKANTRKFLQAFVDANPLLEKLPSVDFCEWVYSECTSKGVDLYLDERAVVQLPEMSSGIVGKYALVTSINLSYGKNTLKGTLPASWGSLTHLEYISMYSNSLTGTLPPEWANMKSAKWFLLYRNELTGTIPEAWSRLRYMTWACLNDNNLTGTLPSSWGSAPQLTIVEARRNQLTGTLPPTWGSLRKLSSITLTDNNLTGPLPEEWASAQTLYGVSVERNNLCGCVPKSWVSHNFLYGMQVDDSLLAADCSTANACTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5R1</accession>
    <accession>E9BNY9</accession>
    <name>A0A3S7X5R1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_20730</name>
        <name evidence="12" type="ORF">LDBPK_322380</name>
        <name evidence="11" type="ORF">LdCL_320029100</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863651.1">
        <property type="nucleotide sequence ID" value="XM_003863603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5R1"/>
    <dbReference type="GeneID" id="13390939"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320029100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2950"/>
    <dbReference type="OMA" id="CQMMGSV"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="237"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="507"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU81782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP43747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="773" mass="85742" checksum="C7449744AE1C0035" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6N8</accession>
    <accession>E9BQ63</accession>
    <name>A0A3S7X6N8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Mitochondrial_RNA_binding_protein_putative/GeneDB:LmjF.33.1250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_331320</name>
        <name evidence="2" type="ORF">LdCL_330019400</name>
        <name evidence="3" type="ORF">LDHU3_33.1970</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863958.1">
        <property type="nucleotide sequence ID" value="XM_003863910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6N8"/>
    <dbReference type="SMR" id="A0A3S7X6N8"/>
    <dbReference type="GeneID" id="13392353"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1970"/>
    <dbReference type="OMA" id="GARWQTH"/>
    <dbReference type="OrthoDB" id="269556at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="CDD" id="cd23678">
        <property type="entry name" value="RESC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000010">
        <property type="entry name" value="Mitochondrial RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058722">
        <property type="entry name" value="RESC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26170">
        <property type="entry name" value="RESC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 5 protein" evidence="1">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35712" checksum="66881C7AB7F3C572" modified="2019-05-08" version="1">MRATRSVRAVHAFVRMPHHRSVPPTGPSGILVNRDVLFRQFRDFYRTLQHSTLVDKVHLMAERPGVESLRVADQMASLGPVLLGMPLTGMEHRSSEFLETMRYVRGAGGPTTVSAYLQDNDACRCHSGDIVCLPQGIAVGHGPRTNAAAHQVLRELFGSGEAADGGDGPAVASPGRTSKFEVVTLEQEGDAPPLGDYFGFAGNNILLVWKDEHGLLAVDQLQQQLTQSELQLQVLYLEPGCHFFTFYGVDYTPDVLVQKGFERSMDTIAAAGLNPIAVQWSEMDKLGISMRSAVLPLKFLQSPSSTGGLLQRSRNRGNRWAASQITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X790</accession>
    <accession>E9BPR7</accession>
    <name>A0A3S7X790_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">40S_ribosomal_protein_S13_putative/GeneDB:LmjF.19.0390/GeneDB:LmjF.33.3150</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ribosomal S13/S15 N-terminal domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_9130</name>
        <name evidence="12" type="ORF">CGC20_9780</name>
        <name evidence="11" type="ORF">CGC21_5575</name>
        <name evidence="9" type="ORF">LDBPK_333300</name>
        <name evidence="6" type="ORF">LdCL_330040600</name>
        <name evidence="7" type="ORF">LDHU3_19.0440</name>
        <name evidence="8" type="ORF">LDHU3_33.4780</name>
    </gene>
    <organism evidence="6 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6 14" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000051">
        <property type="protein sequence ID" value="TPP42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864153.1">
        <property type="nucleotide sequence ID" value="XM_003864105.1"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="T=1-151"/>
    </dbReference>
    <dbReference type="PDBsum" id="6AZ1"/>
    <dbReference type="AlphaFoldDB" id="A0A3S7X790"/>
    <dbReference type="EMDB" id="EMD-7024"/>
    <dbReference type="SMR" id="A0A3S7X790"/>
    <dbReference type="GeneID" id="13392549"/>
    <dbReference type="KEGG" id="ldo:LDBPK_333300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330040600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4780"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="268585at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5429425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5433538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP55362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6AZ1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17419" checksum="C79B0B0FA6E9CC51" modified="2019-05-08" version="1">MVRMHGNGRGKASSALPYRRTPPAWLKIASRNVVKMVCKSSRKGMMPSQIGMELRDSMGIAQVKNVTGRKILRILKHSGLAPEIPEDLYFLVKRATQMRKHLERHTTDRDTKYRLILVESRIHRLARYYKRVKQLPPTWKYESSTASAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X907</accession>
    <accession>E9BS06</accession>
    <name>A0A3S7X907_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_6185</name>
        <name evidence="3" type="ORF">LDBPK_351300</name>
        <name evidence="2" type="ORF">LdCL_350017900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864715.1">
        <property type="nucleotide sequence ID" value="XM_003864667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X907"/>
    <dbReference type="GeneID" id="13387595"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1720"/>
    <dbReference type="OMA" id="NSRKPYF"/>
    <dbReference type="OrthoDB" id="246298at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="249" mass="27368" checksum="14759A550CBBBFEF" modified="2019-05-08" version="1">MTVSPSAAATAAPTIFIRCATLHSRGELLNGFFFAHRATLGIQDWYETARTPVSGGTGNEEEKLSSAEDSAAAGDTPHTALSPRLPPHFPVEVLYVRNSRKPYFLVEWRYPTSEEEGKRKDPSDGSSGVKEGVTEVHEARAGSSQNRVTEEFLRQLAERTLALGKQELSDDGATWKGQPVFISAALPGMTVVAERRKLELRDAQLKIQRATEKRERAEDDSAAQTAKTKQRDSGVVASAFIPRCVRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X929</accession>
    <accession>E9BS40</accession>
    <name>A0A3S7X929_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_6330</name>
        <name evidence="3" type="ORF">LDBPK_351640</name>
        <name evidence="2" type="ORF">LdCL_350021300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864749.1">
        <property type="nucleotide sequence ID" value="XM_003864701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X929"/>
    <dbReference type="GeneID" id="13387629"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2180"/>
    <dbReference type="OMA" id="EALWQLK"/>
    <dbReference type="OrthoDB" id="261804at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="356" mass="38834" checksum="EE29AD83BD408D06" modified="2019-05-08" version="1">MPSRIVRDPGVPPTLVARPEDVFEDSGSGYSSMWAHALNGVAVGERYDTAKSSAAATLPVKWDRDEALWQLKIALGVSPVLRERDVPHLASPALRTHSSAQVPLELKAGDEAAAAVAQKTSTSDKQPPSAQEGASRKGNRLDHFIPPVYRFSSASSASSSPLSQAYVQTALARIQDECDALMQRLGVGAAKSSAELNQANTDMPDDELQAAQLMRLLAEPSTLAQLQRRADAAILEKECVFRIRDLLAAELQRRHVPLEAAQDDFYPFFEQVDRTKMALEDYYHVQSAMHTMAPMMEAAVAVAECLRDVDATTSMQGMQRISAAEAAMNSLLAQVQEDAVMLQKNLEALRCRFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9W0</accession>
    <accession>E9BSS8</accession>
    <name>A0A3S7X9W0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LDBPK_354080</name>
        <name evidence="11" type="ORF">LdCL_350045900</name>
        <name evidence="12" type="ORF">LDHU3_35.5300</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864986.1">
        <property type="nucleotide sequence ID" value="XM_003864938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9W0"/>
    <dbReference type="GeneID" id="13387864"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350045900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5300"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="264"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ38307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="690" mass="78947" checksum="219FF6722D5876A8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA65</accession>
    <name>A0A3S7XA65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_350057700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA65"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350057700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6920"/>
    <dbReference type="OrthoDB" id="272605at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="318" mass="35258" checksum="57F597D49DCCA008" modified="2019-05-08" version="1">MANTSATASDELHRTQQYLVEVIDECVFVERQRELTERRLSSQLEAQKALVSDLFVVLHDVCRYTSTMEEAILTTLLHTLPASSPAHQQLLQCRSRVREALTRLWRGRGGDREDSVLLPATPRTFSGLRAADAPIISHDSAAGAGVQVMQRLVEHEARLLDALARATARIEATRAAETAENGELEALRARMNELTRVVNSSNTGLLKTSPEASAAQAPEGVSPATARFAEARVLAYEKTVQALNSELALLHENYAALSHARTREVDMLKQHMADDQRKHEDQIAECDAVLGRMSLELEQLIQENAQLKHKLRMTAEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAL4</accession>
    <name>A0A3S7XAL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360013000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1060"/>
    <dbReference type="OrthoDB" id="273441at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1290" mass="137431" checksum="BB7ADB1CEEB73275" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBW0</accession>
    <accession>E9BUT9</accession>
    <name>A0A3S7XBW0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_15185</name>
        <name evidence="2" type="ORF">LDBPK_365820</name>
        <name evidence="1" type="ORF">LdCL_360065600</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865695.1">
        <property type="nucleotide sequence ID" value="XM_003865647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBW0"/>
    <dbReference type="GeneID" id="13388581"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360065600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7720"/>
    <dbReference type="OMA" id="FRCGDPR"/>
    <dbReference type="OrthoDB" id="269924at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ39018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="372" mass="41004" checksum="CDC8D76F79757838" modified="2019-05-08" version="1">MATINTELSLVRRFHALLQNYDSRPTVARRNTLPTLSRFLRSKDRQIRKLSLEAVYLLAEHHENLELLGNDHDLVDGVVEIYDGARYDDPELYDLSNKTLDLLAPAFRCGDPREAVARRAEQDAGVASAGAVPLCPTPLPDAGSSSELPDLSNAVREYDTIMGDGHAEAVGDFDQLSVISGGTGFEMASSSSHLTRRMTDPALRPSEVIRGVGKDCPLSIVLEIPALDAMTDTSHIEEILQTTRGVVSYTITASAHQIRVFLSAFAQAPLQNMLTEAGYENLLTSAERMRYQGSDAGNQSLNGSFFYDQQNKRPSYVQSAKNFASNLFNSVMVYSDPRNNSLAARIRQQRAVKEEGGSTTADRIAQAFSRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJB3</accession>
    <name>A0A451EJB3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_010011000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJB3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0680"/>
    <dbReference type="OrthoDB" id="278519at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="964" mass="101031" checksum="25B39A721EC517A7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJC2</accession>
    <name>A0A451EJC2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_010012000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJC2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010012000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0790"/>
    <dbReference type="OrthoDB" id="267772at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="804" mass="84266" checksum="75805811329816B1" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-09-11" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A7LBL3</accession>
    <accession>E9B810</accession>
    <name>A7LBL3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="4 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ASL</name>
        <name evidence="17" type="ORF">CGC20_15700</name>
        <name evidence="16" type="ORF">CGC21_2670</name>
        <name evidence="15" type="ORF">LDBPK_040440</name>
        <name evidence="14" type="ORF">LdCL_040009900</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Murnane C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 18" key="2">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2013-09" db="PDB data bank">
            <title>Crystal Structure of adenylosuccinate lyase from Leishmania donovani.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Loppnau P."/>
                <person name="Dong A."/>
                <person name="Krojer T."/>
                <person name="Bradley A."/>
                <person name="Bushell S."/>
                <person name="von Delft F."/>
                <person name="Robinson D."/>
                <person name="Gilbert I."/>
                <person name="Bountra C."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Mottaghi K."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH AMP</scope>
    </reference>
    <reference evidence="14 19" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="20" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 9"/>
    <dbReference type="EMBL" id="EF999429">
        <property type="protein sequence ID" value="ABS11226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000064">
        <property type="protein sequence ID" value="TPP52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858107.1">
        <property type="nucleotide sequence ID" value="XM_003858059.1"/>
    </dbReference>
    <dbReference type="PDB" id="4MX2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-479"/>
    </dbReference>
    <dbReference type="PDBsum" id="4MX2"/>
    <dbReference type="AlphaFoldDB" id="A7LBL3"/>
    <dbReference type="SMR" id="A7LBL3"/>
    <dbReference type="GeneID" id="13390718"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040009900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0600"/>
    <dbReference type="OMA" id="NNWAVVA"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01598">
        <property type="entry name" value="PurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000010">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000011">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000004">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047136">
        <property type="entry name" value="PurB_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006764">
        <property type="entry name" value="PRK09285.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43411:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="22" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylosuccinate lyase PurB C-terminal" evidence="12">
        <location>
            <begin position="357"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABS11226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU75823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP51466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="4MX2"/>
        </source>
    </evidence>
    <sequence length="479" mass="53552" checksum="F5AAAF36C2E5E4FC" modified="2007-09-11" version="1">MSLPSAEEAAAPAVTTTAHKAPAEISQDSPLYSLSPLDGRYKRDTTPLRAYFSEYALFKYRVQVEVLYFEALCKEVPAITQLRGVTDAQLGELRATTFENFAVDDAKIIKGIEAVTNHDIKAVEYYLKDKMSACGLEAEKEFIHFGLTSQDINNTSIPMLLRDALHHHYIPTLDQLIALLKSKLPEWDVPMLARTHGQPASPTNLAKEFMVWIERLEEQRTMLLSIPNTGKFGGATGNFNAHLCAYPGVNWLDFGELFLSKYLGLRRQRYTTQIEHYDNLAAICDACARLHTILMDLAKDVWQYISLGYFDQKVRAGEVGSSAMPHKVNPIDFENAEGNLGMSNAVLGFLSAKLPISRLQRDLTDSTVLRNLGVPLSHALIAFASLRRGIDKLLLNKDVIASDLEGNWAVVAEGIQTVLRREGYPKPYEALKDLTRGNAHVTEETVHRFVQQLEGITEEVRQELLAITPFTYVGYTAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7B0</accession>
    <accession>A0A3S5H4V2</accession>
    <name>E9B7B0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_010460</name>
        <name evidence="8" type="ORF">LdCL_010009600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857859.1">
        <property type="nucleotide sequence ID" value="XM_003857811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7B0"/>
    <dbReference type="GeneID" id="13389715"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0490"/>
    <dbReference type="OMA" id="TWVECAL"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="PhylomeDB" id="E9B7B0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="589" mass="62241" checksum="DF2760A2769D6506" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7D7</accession>
    <accession>A0A3S7WNL1</accession>
    <name>E9B7D7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="4">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_010730</name>
        <name evidence="7" type="ORF">LdCL_010012300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="4"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857886.1">
        <property type="nucleotide sequence ID" value="XM_003857838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7D7"/>
    <dbReference type="GeneID" id="13389732"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0830"/>
    <dbReference type="OMA" id="IECEMYL"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="PhylomeDB" id="E9B7D7"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000009">
        <property type="entry name" value="Ubiquitin activating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="34"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="539" mass="57509" checksum="457A4C5604794706" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8U2</accession>
    <accession>A0A3S7WPI6</accession>
    <name>E9B8U2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_060820</name>
        <name evidence="4" type="ORF">LdCL_060013300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858388.1">
        <property type="nucleotide sequence ID" value="XM_003858340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8U2"/>
    <dbReference type="GeneID" id="13391748"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0950"/>
    <dbReference type="OMA" id="FWWWLAL"/>
    <dbReference type="OrthoDB" id="267386at2759"/>
    <dbReference type="PhylomeDB" id="E9B8U2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044730266" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="110931" checksum="FC5CFA305A0DCE40" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAL8</accession>
    <accession>A0A3S7WRJ0</accession>
    <name>E9BAL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec20, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_110300</name>
        <name evidence="9" type="ORF">LdCL_110007900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859007.1">
        <property type="nucleotide sequence ID" value="XM_003858959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAL8"/>
    <dbReference type="GeneID" id="13389825"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0360"/>
    <dbReference type="OMA" id="ERQLYMR"/>
    <dbReference type="OrthoDB" id="267919at2759"/>
    <dbReference type="PhylomeDB" id="E9BAL8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="274" mass="30034" checksum="54B8A89E805B9D64" modified="2011-04-05" version="1">MEATAALRAAAASPSPPSASPLPPRTAEVLLSLAHRADQALHELITTHHAFVTNRTQRLHGALSIAAAHAQLVLRTLETVREQRERERHRVHQQLQQRSGSSASPATRTASPSVANRAPTKEERQLYMRLEKARIDLRRVLPRAVAEVEDAENVTEGDVTSTSGRSAASTAAALRSLLHTRSMLSMELKKMDTAVQGLAGSSESLATLQQSLQDVHSSMEMAQRMVRTLLTVQSRDDLLLRVSAVLFALVVLYVVAQRVFRLFPTTVYVTLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BD33</accession>
    <accession>A0A3S5H6Z6</accession>
    <name>E9BD33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_170060</name>
        <name evidence="2" type="ORF">LdCL_170005600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859866.1">
        <property type="nucleotide sequence ID" value="XM_003859818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BD33"/>
    <dbReference type="GeneID" id="13393326"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0080"/>
    <dbReference type="OMA" id="PHFHFYE"/>
    <dbReference type="OrthoDB" id="272391at2759"/>
    <dbReference type="PhylomeDB" id="E9BD33"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="237" mass="26926" checksum="D4F29DA8D6DE75C8" modified="2011-04-05" version="1">MGQAVMEDQGNSLVVWGSTGRRLQFSMQDLKLPASLRDNPHFHFYEKQWDAVASFWFNRVLKESALQHLSVEAIIELIREDISKRWERRRQEQSIYKKRKRLLQRSGPAGTPSSSVLLTNVTTLEGYHAATEMEQKDLVTALVERVEDVAKDKVESWRVLIDDASEQRPAKAARVEGTTATSGEHSENDADAAGDFDDRVAVILKLSSKEKAATTIAHLHGSRFDDRRVLCRFWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDN0</accession>
    <accession>A0A3S5H729</accession>
    <name>E9BDN0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_180490</name>
        <name evidence="2" type="ORF">LdCL_180009800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860063.1">
        <property type="nucleotide sequence ID" value="XM_003860015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDN0"/>
    <dbReference type="GeneID" id="13393492"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180009800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0610"/>
    <dbReference type="OMA" id="HRIFGPI"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="PhylomeDB" id="E9BDN0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF143">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="288" mass="31963" checksum="BE21AC368A211F49" modified="2011-04-05" version="1">MSAAVTWLQNSLGIDVTGEWARHVHLNVGGTLYTTRRYTLRELKDHRIFGPILDGHAHRCEDGSFLIDRDGSLFRYIIAYLRDGRLSVPDNFVEWDMLLQEVRYYELPAMEKSVMDRFEFQQSVFRRQLPHGVYVWWPPASSHIEEGATVKAAPCDCPASAPTPPTSLFALSITDRATGRGEARGATEDQTRALEKEHAEAAADAATRSSAGVAPSSCSSASLPIRIVPPLPGLTVEAASGRWVVFRETQVLEDLDQLVTVLLTAYGFSIQHWDAERGRVLLTLPGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BF28</accession>
    <accession>A0A3Q8IF20</accession>
    <name>E9BF28_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rtr1/RPAP2 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_210430</name>
        <name evidence="2" type="ORF">LdCL_210009100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860560.1">
        <property type="nucleotide sequence ID" value="XM_003860512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BF28"/>
    <dbReference type="GeneID" id="13386388"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0450"/>
    <dbReference type="OMA" id="NYNELCG"/>
    <dbReference type="OrthoDB" id="273314at2759"/>
    <dbReference type="PhylomeDB" id="E9BF28"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="725" mass="77509" checksum="268A1AD4F56B8554" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9BF83</accession>
    <accession>A0A3S7WWJ0</accession>
    <name>E9BF83_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_210970</name>
        <name evidence="3" type="ORF">LdCL_210014700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860614.1">
        <property type="nucleotide sequence ID" value="XM_003860566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BF83"/>
    <dbReference type="GeneID" id="13386421"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1140"/>
    <dbReference type="OMA" id="FTICTLW"/>
    <dbReference type="OrthoDB" id="264817at2759"/>
    <dbReference type="PhylomeDB" id="E9BF83"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36625" checksum="8A2DA7E479F61430" modified="2011-04-05" version="1">MMLRLSRRRLATSIGGFSSAAFTGDDGGAYERRKSEQERLKRDHQQEGTGAQEQQPHNGGGDAQHAGTPVSASMSSSSFWEETCSPSGFHGTKGSSSGSGNAAYAAEANAPLARPTIDTYRAMTDSELVETLRTRDEQIRQLRAIYESFHYDADRHFRKMIFDYHDKTMQLSQVHGRMQQASLQINREALSKMRDQQDMMTRDKRIIFTICTLWTLIFWVWVRRHYVKRRELELEPLDGREWAQMSPSITGAGSYNENVFGSNKRNARFTETAWERELRERREAQNLREQQVALLRNQMELQKAVATQREQQQACDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGV8</accession>
    <accession>A0A3Q8ICU6</accession>
    <name>E9BGV8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_240950</name>
        <name evidence="2" type="ORF">LdCL_240014500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861186.1">
        <property type="nucleotide sequence ID" value="XM_003861138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGV8"/>
    <dbReference type="GeneID" id="13390871"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240014500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1120"/>
    <dbReference type="OMA" id="TACPCAN"/>
    <dbReference type="OrthoDB" id="273477at2759"/>
    <dbReference type="PhylomeDB" id="E9BGV8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="99279" checksum="42ABDFCB256DBAFA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHV1</accession>
    <accession>A0A3Q8IGP4</accession>
    <name>E9BHV1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_251970</name>
        <name evidence="1" type="ORF">LdCL_250025500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861527.1">
        <property type="nucleotide sequence ID" value="XM_003861479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHV1"/>
    <dbReference type="GeneID" id="13388773"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251970"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251970.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250025500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2440"/>
    <dbReference type="OMA" id="TITFCFH"/>
    <dbReference type="OrthoDB" id="259603at2759"/>
    <dbReference type="PhylomeDB" id="E9BHV1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23633" checksum="8DBB8380E9545918" modified="2011-04-05" version="1">MMGSLFVEKCTPQLYAQGAPQKHTTARMSSSVCDAPQATTCSTATPEHPAVELQPALRQRTITFCFPGPSSVSSTGAAAAAEVADDGNDESIRVVLHLSVRCFVDYVLLFVTEEQTCAPGVLLRYDAPAIGPGAFMYDDETPSLDFAVLLGLRDHPLTNLLASAIAHRIRRYGETRPLLMGLSVVQTAKKLNSSHAKKLFLDGAASNLLELAWEVQSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIF3</accession>
    <accession>A0A3S7X006</accession>
    <name>E9BIF3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_261410</name>
        <name evidence="6" type="ORF">LdCL_260019700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861728.1">
        <property type="nucleotide sequence ID" value="XM_003861680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIF3"/>
    <dbReference type="GeneID" id="13388974"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1720"/>
    <dbReference type="OMA" id="HNVPACA"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="PhylomeDB" id="E9BIF3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000025">
        <property type="entry name" value="Cytochrome b5-like Heme/Steroid binding domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1148" mass="118281" checksum="B2F8B840396A759A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKX5</accession>
    <accession>A0A3S7X2J0</accession>
    <name>E9BKX5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-finger domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_291770</name>
        <name evidence="7" type="ORF">LdCL_290023300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862596.1">
        <property type="nucleotide sequence ID" value="XM_003862548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKX5"/>
    <dbReference type="GeneID" id="13387332"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2540"/>
    <dbReference type="OMA" id="IVTHRCR"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="PhylomeDB" id="E9BKX5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134975" checksum="F535BD32EBDD19F5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSJ5</accession>
    <accession>A0A3Q8IMJ6</accession>
    <name>E9BSJ5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_353250</name>
        <name evidence="4" type="ORF">LdCL_350037500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864904.1">
        <property type="nucleotide sequence ID" value="XM_003864856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSJ5"/>
    <dbReference type="GeneID" id="13387782"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350037500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4270"/>
    <dbReference type="OMA" id="PHTLNTV"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="PhylomeDB" id="E9BSJ5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001444">
        <property type="entry name" value="RNA-binding_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="310"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="704" mass="74562" checksum="62B51A1664113255" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSK6</accession>
    <accession>A0A3Q8IJ91</accession>
    <name>E9BSK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_353350</name>
        <name evidence="4" type="ORF">LdCL_350038500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864915.1">
        <property type="nucleotide sequence ID" value="XM_003864867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSK6"/>
    <dbReference type="GeneID" id="13387792"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350038500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4400"/>
    <dbReference type="OMA" id="GHATGEV"/>
    <dbReference type="OrthoDB" id="271805at2759"/>
    <dbReference type="PhylomeDB" id="E9BSK6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="635" mass="68364" checksum="3C9C37DFC0486473" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUK9</accession>
    <accession>A0A3Q8IHR7</accession>
    <name>E9BUK9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paraflagellar rod component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_365010</name>
        <name evidence="1" type="ORF">LdCL_360057300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865615.1">
        <property type="nucleotide sequence ID" value="XM_003865567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUK9"/>
    <dbReference type="ESTHER" id="leima-q4q0t5">
        <property type="family name" value="Fusarinine_C_esterase_sidJ"/>
    </dbReference>
    <dbReference type="GeneID" id="13388501"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360057300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6730"/>
    <dbReference type="OMA" id="YKDPYCK"/>
    <dbReference type="OrthoDB" id="271876at2759"/>
    <dbReference type="PhylomeDB" id="E9BUK9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="317" mass="33572" checksum="6FBF02765FC62A42" modified="2011-04-05" version="1">MEGRLVILPRDGMHKTSMFLVGTAHRCILAVGSQSEGLLATPYVQEMADALKGEWTIAHVVLGSSHVGRSAPSHEADADDVDAALALLVKEHSMNEVVLYASGTGVQVALEALASAAHAEVVTRVILQGGIVSPQRSKLFSVEATKRRLEMARALIAEKRGDDTTAMAKVYDMAVTPARLSRNATLTVQEALWQPVLGESESTCKQTLRGVTVPTLFLLSTEASYTAAAKDAVPAVQRAARDAIGLPTEDVQVTLLPTTIDEHRCALNGNGALAVKAVSDFLQGADARRAQFEPGTTVVALEAKQKKEVTLVNGVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H9D0Z2</accession>
    <accession>E9BCR1</accession>
    <name>H9D0Z2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amidohydrolase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6 7">Dihydroorotase</fullName>
            <ecNumber evidence="7">3.5.2.3</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Dihydroorotase_putative/GeneDB:LmjF.16.0580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DHO</name>
        <name evidence="10" type="ORF">CGC20_36520</name>
        <name evidence="11" type="ORF">CGC21_25065</name>
        <name evidence="9" type="ORF">LDBPK_160580</name>
        <name evidence="7" type="ORF">LdCL_160010900</name>
        <name evidence="8" type="ORF">LDHU3_16.0710</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2012" name="J. Biol. Chem." volume="287" first="12759" last="12770">
            <title>Genetic Dissection of Pyrimidine Biosynthesis and Salvage in Leishmania donovani.</title>
            <authorList>
                <person name="Wilson Z.N."/>
                <person name="Gilroy C.A."/>
                <person name="Boitz J.M."/>
                <person name="Ullman B."/>
                <person name="Yates P.A."/>
            </authorList>
            <dbReference type="PubMed" id="22367196"/>
            <dbReference type="DOI" id="10.1074/jbc.M112.346502"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DI700</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="7"/>
    <dbReference type="EMBL" id="JQ436845">
        <property type="protein sequence ID" value="AFC97130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000028">
        <property type="protein sequence ID" value="TPP40953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859745.1">
        <property type="nucleotide sequence ID" value="XM_003859697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H9D0Z2"/>
    <dbReference type="SMR" id="H9D0Z2"/>
    <dbReference type="GeneID" id="13393172"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0710"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="BRENDA" id="3.5.2.3">
        <property type="organism ID" value="2947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024403">
        <property type="entry name" value="DHOase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12890">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotase catalytic" evidence="5">
        <location>
            <begin position="13"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFC97130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP40953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP51181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="405" mass="43901" checksum="A4FD3854D137B416" modified="2012-05-16" version="1">MSSAPMSATAVVQLPPLIDCHVHFREPGLEHKADIASESTAAYYGGITVACDMPNTSPPTQSIAALADKVARSKATAHADCQLFFFFGATAEAHLQELQELWTNPAHAELKTHCCGLKLYLDNSTGNMKSSRSVVEKSFEMCGRLQIVLVAHCEQSEINDAAAAQHPYDGPASHSLRRPADSEAASVQSAIDLARQCRTPLHLAHVSTAQSLDLVREARAADPTLQLTCEVTPHHLFLTTSDYSCCGARVKVNPPVRPPPHHEALWAGLLDGTVDCVGTDHAPHTIAEKDHCDGAAQPPSGMPAIEVVVPLLLTVVAGHWPHPTAAKPSTLAAAEQQGCTLTLDDIVRVLHTNPNRIFNLRQPDAPHRSFDLACEWTVRGEELHSKCRWSPYEGWRLRGRALAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8N5</accession>
    <name>A0A3Q8I8N5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_090020900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8N5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1700"/>
    <dbReference type="OrthoDB" id="273263at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="580" mass="62332" checksum="6D25860CD2166A3A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I939</accession>
    <accession>E9BAT7</accession>
    <name>A0A3Q8I939_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adaptin N terminal region family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Adaptin-related protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC21_0765</name>
        <name evidence="9" type="ORF">LDBPK_110990</name>
        <name evidence="8" type="ORF">LdCL_110015700</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859075.1">
        <property type="nucleotide sequence ID" value="XM_003859027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I939"/>
    <dbReference type="GeneID" id="13389856"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110015700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1220"/>
    <dbReference type="OMA" id="QVEMMWS"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP53001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="991" mass="108494" checksum="79492D5E6C3BBEF8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I987</accession>
    <name>A0A3Q8I987_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_150020800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I987"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1870"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000025">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000043">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="601"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="681"/>
            <end position="685"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="940" mass="103774" checksum="8E46B2BE9985D0E9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9E6</accession>
    <name>A0A3Q8I9E6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal region of Chorein, a TM vesicle-mediated sorter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_160013100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0940"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF140">
        <property type="entry name" value="PEROXIN_FERLIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="82"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1667"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1932"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2138"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2171"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2404"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2510"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2606"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2901"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3049"/>
            <end position="3152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3219"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3441"/>
            <end position="3464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4353"/>
            <end position="4377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="5327"/>
            <end position="5354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="5403"/>
            <end position="5520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1453"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2141"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2178"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2406"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2521"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2612"/>
            <end position="2628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2908"/>
            <end position="2919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3064"/>
            <end position="3073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3111"/>
            <end position="3148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3452"/>
            <end position="3464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="4357"/>
            <end position="4374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="5334"/>
            <end position="5344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="5407"/>
            <end position="5419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="5440"/>
            <end position="5454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="5494"/>
            <end position="5503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="5508"/>
            <end position="5518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="5664" mass="606196" checksum="E3539F41C1A16301" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAW2</accession>
    <name>A0A3Q8IAW2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPPDE putative peptidase domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_090020000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAW2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1610"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24180" checksum="40EB716DED93FA37" modified="2019-04-10" version="1">MHATKSGVTTLSASAGKSDVPAMPAGYEDAAGQPNAVFVNVYDIMKSNSWLWSVGLGVHHAGIQVYDKEYQYGRCEEGSGVRVVEPRHSPPHIFREQFFVGQTQLSALEVRELVATLEQRDTWQGNKYHLVKHNCIHFAHALCEALLPPHVRVAQMRTALPSTYQSAYMEEVEVDGQQYSLPVLIPPHVSRLGSYAASYLPESVLQLLDSMDNPFSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBA2</accession>
    <accession>E9BFJ5</accession>
    <name>A0A3Q8IBA2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L32</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L32 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_34655</name>
        <name evidence="6" type="ORF">LDBPK_212090</name>
        <name evidence="5" type="ORF">LdCL_210026600</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2016" name="Cell Rep." volume="16" first="288" last="294">
            <title>2.8-A Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Matzov D."/>
                <person name="Halfon Y."/>
                <person name="Zackay A."/>
                <person name="Rozenberg H."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="27373148"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2016.06.014"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.80 ANGSTROMS)</scope>
    </reference>
    <reference evidence="5 9" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860726.1">
        <property type="nucleotide sequence ID" value="XM_003860678.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JCS">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="f=1-133"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JCS"/>
    <dbReference type="PDBsum" id="6AZ3"/>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBA2"/>
    <dbReference type="SMR" id="A0A3Q8IBA2"/>
    <dbReference type="GeneID" id="13386550"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210026600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2480"/>
    <dbReference type="OMA" id="GPHNTAK"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP49423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="3JCS"/>
        </source>
    </evidence>
    <sequence length="133" mass="15341" checksum="736476D943C14523" modified="2019-04-10" version="1">MVKPTVSKAIVKKRTKRFTRHRYELFPQLSSSWRKPRGEDSPVRRRYKGQKAMPNKGYGSDRATKYITPSGFRSFPINNVEDLYMLVMQNRKYAGVISHTVGARTRKAIARKAMELDVRLANGNAKLRKIANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC39</accession>
    <name>A0A3Q8IC39_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-finger protein, conserved</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Zinc-finger_protein_conserved/GeneDB:LmjF.30.2360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_300029200</name>
        <name evidence="9" type="ORF">LDHU3_30.3210</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC39"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300029200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3210"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5432261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="546" mass="60655" checksum="BDC1CA7925EFAC69" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC49</accession>
    <name>A0A3Q8IC49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_220010000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC49"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0680"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="728" mass="78102" checksum="9CBCDCC825F92951" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IC63</accession>
    <name>A0A3Q8IC63_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridylate synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260017000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IC63"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1420"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="976" mass="103828" checksum="C32B62915498CFB0" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICM8</accession>
    <accession>E9BI54</accession>
    <name>A0A3Q8ICM8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudouridylate synthase-like protein</fullName>
            <ecNumber evidence="3">4.2.1.70</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_31620</name>
        <name evidence="4" type="ORF">LDBPK_260410</name>
        <name evidence="3" type="ORF">LdCL_260009600</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.70" evidence="3"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861630.1">
        <property type="nucleotide sequence ID" value="XM_003861582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICM8"/>
    <dbReference type="GeneID" id="13388875"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0530"/>
    <dbReference type="OMA" id="FIPRHCC"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000036">
        <property type="entry name" value="Pseudouridylate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF26">
        <property type="entry name" value="SYNTHASE I, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="696" mass="76536" checksum="32A13C5107B6A78B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICP0</accession>
    <name>A0A3Q8ICP0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310030800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICP0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310030800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4070"/>
    <dbReference type="OrthoDB" id="266657at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="840" mass="90807" checksum="DA4046723BB41EBD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID75</accession>
    <name>A0A3Q8ID75_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250013700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID75"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250013700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1050"/>
    <dbReference type="OrthoDB" id="273176at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1021" mass="108905" checksum="D15450C9384E54C6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDZ9</accession>
    <accession>E9BDA9</accession>
    <name>A0A3Q8IDZ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Ysine decarboxylase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ysine_decarboxylase-like_protein/GeneDB:LmjF.17.0 735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_37650</name>
        <name evidence="5" type="ORF">CGC21_4060</name>
        <name evidence="4" type="ORF">LDBPK_170880</name>
        <name evidence="2" type="ORF">LdCL_170014800</name>
        <name evidence="3" type="ORF">LDHU3_17.1290</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000040">
        <property type="protein sequence ID" value="TPP55085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859942.1">
        <property type="nucleotide sequence ID" value="XM_003859894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDZ9"/>
    <dbReference type="SMR" id="A0A3Q8IDZ9"/>
    <dbReference type="GeneID" id="13393359"/>
    <dbReference type="KEGG" id="ldo:LDBPK_170880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1290"/>
    <dbReference type="OMA" id="INAHRTK"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000098">
        <property type="entry name" value="Ysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000048">
        <property type="entry name" value="Ysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP55085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="322" mass="35340" checksum="FAD6AD0D0CC4018D" modified="2019-04-10" version="1">MVVAAVFTIKLRDGEAEQQFLDAFAPLQQHSVRNEPGTLTYELHQVFENGQPVPLQYLVLERYSSMRDFEEIHLKSAPLQNLFKVVAGIAVEEQKLTVYSNVASQPAMDSRPQVWSDKDTEDPLLQKGVLVFAGARSGSKPAYTQEAKALAKYIVEEAKQPVVYGGGTVGVMGELAKEAHALNGKIISIIPNALSESEVSGPMIGDRIYTTATMSERKSIMFAHANTVVALPGGVGTFDELLEVITLFQLNAYRPKIGIVNVEGFFDPFVALLRHLMAEGFLEEKVFDFLVIAPTAIEVMETLKSFVPPPSPASTLIWTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE70</accession>
    <name>A0A3Q8IE70_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase, putative</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_32730</name>
        <name evidence="5" type="ORF">LdCL_220010400</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE70"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0720"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="312"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="439" mass="46465" checksum="294AFEAD606E6C5F" modified="2019-04-10" version="1">MSSFQAHVAKLARAAESVSADAEQAPPAVAIPLREAAQSLPPHIIAATDPVKLNKQASIFRCPAWAGLPSRPFHLHCVRGKVPYPALGLQRFPYYLFGKNPVCDYVLEHPSISSVHAALIFNKEHVCFVLLDLGSTNGVRLEGKRVEPRKPIPIAVGSVLQFGYSTRTYELRAGAPPQLKRLREDGDEDTAAQRHGSGLASADSGLCEADKVSLSAAVAGTATCPATAPSAVIASATSAATAVSPAPEGQVANEPRTSSTTAEAATSSAHGAVTSDVGRMAEPAATTVMHATADATGGSPAEAATASAAAEYAPIHLFQLVIKHKDVENPISRGRNKGEIITRSRADALDMARYILADHRRRVPVAPDLGFSPWTPEEFVAAVDEYCEMSAKKKRGDLGVVEKGTFADEIDKAAFRLRRGEVSAPVETQLGVHLLYRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE71</accession>
    <name>A0A3Q8IE71_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LdCL_290005000</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE71"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290005000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0010"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF172">
        <property type="entry name" value="ISOMERASE, MITOCHONDRIAL, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYU80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="296" mass="32442" checksum="F383DFAB1E6494E7" modified="2019-04-10" version="1">MRCFRASCCAPPPRSRACSTVASVPDTSDLIIVRESPIDNVVLLEMNSGRANVLTPKFISAFLNKLSDLCDPDKSRCSGIILTSKNPGVFSAGLDLNELNTNLSQDRFAHYWSQFQKLFTTLHALPVPLVGAINGHAAAAGCIVALACDYRVMARRHPTKPAHLTIGIAAAKHGFVVPSYVAASMEHVVGFRKAEELLCTGLLLPADEALQVGLVDEVVEHHDEAVVPCLQFMEKLLELPSPAPYWMIKDMSRRHILAPLCTPALRTQDTVSFYNLFSNPQVKKKLAEHAQKFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEE7</accession>
    <accession>E9BJ69</accession>
    <name>A0A3Q8IEE7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit RPN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_30730</name>
        <name evidence="7" type="ORF">LDBPK_271370</name>
        <name evidence="6" type="ORF">LdCL_270020500</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861990.1">
        <property type="nucleotide sequence ID" value="XM_003861942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEE7"/>
    <dbReference type="GeneID" id="13386724"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2110"/>
    <dbReference type="OMA" id="ILRVHQH"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="83"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00075103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP47504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="334" mass="37873" checksum="7CB34A480BAC62F5" modified="2019-04-10" version="1">MPLAAAKTPINATAATKRAEAEQLTRLMTLYRAVCVRHDELGMEIVLNDILAFLTSTHQHEQAEAFIATCNITLPHRANNQAARYFYYVGLTRALRLEYVDAHQCLQQALRKAPERAFGFRIAATKLSLVVQLLLGEIPPRSDFLAKDMRDSLAPYLQLASCVRFGQVDRFMTVLREHQVAFEHDRTHSLILRVHQHVIKTGLRRICQAYSRISISDVCSKLAMSNVADAEYILSKAIHDGVIDAVLDNEKGELISSDSIDVYSTSEPLHALQRRIQFLNLTHNDAKRAMRYDVTDPEIIEERRKEAKAERDELERAIQDESTGMDNVNFEDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEH7</accession>
    <accession>E9BG79</accession>
    <name>A0A3Q8IEH7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">EF-hand domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_17415</name>
        <name evidence="5" type="ORF">LDBPK_230590</name>
        <name evidence="4" type="ORF">LdCL_230011400</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860960.1">
        <property type="nucleotide sequence ID" value="XM_003860912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEH7"/>
    <dbReference type="GeneID" id="13389921"/>
    <dbReference type="KEGG" id="ldo:LDBPK_230590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230011400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0830"/>
    <dbReference type="OMA" id="EMHPAEL"/>
    <dbReference type="OrthoDB" id="265839at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="307" mass="32076" checksum="227E5AC88C39EDB7" modified="2019-04-10" version="1">MSRTAETVEELARRYYLTTALVEEAGRLFDTYAGSGDAPPANSNEEPFITVPGLQRLMVKMGTPISQHGVVELLRFFGSAAAVAVKEVELSDGPANGQQSPAVKGARSPVAATAPASQQPSSRQRKKKSGATAQKTGAKDAFESSTKLGADHSAGCGASSGTASANSSPLAAPLHVAAPPSAVTAEGMNFSAFVYFLLVYPELSQRPSGMAATASTTNAATRSGLHVSIPELFATIDADADGVWSVHDLRHAAEVCVREDDGLLQEDPDLCHLAEMHPAELAVALHELDVDGDGVVTLDDVRQALYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEH8</accession>
    <accession>E9BM58</accession>
    <name>A0A3Q8IEH8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="3 15">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CGC21_36265</name>
        <name evidence="22" type="ORF">LDBPK_303150</name>
        <name evidence="21" type="ORF">LdCL_300037100</name>
    </gene>
    <organism evidence="21 25">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21 25" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 25">LdCL</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="15">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="3 15"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863026.1">
        <property type="nucleotide sequence ID" value="XM_003862978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEH8"/>
    <dbReference type="SMR" id="A0A3Q8IEH8"/>
    <dbReference type="GeneID" id="13385735"/>
    <dbReference type="KEGG" id="ldo:LDBPK_303150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300037100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4190"/>
    <dbReference type="OMA" id="WFEESSN"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000009">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6 15" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11 15 21" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12 15" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8 15" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5044537151" description="S-adenosylmethionine decarboxylase beta chain" evidence="20">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044537152" description="S-adenosylmethionine decarboxylase alpha chain" evidence="20">
        <location>
            <begin position="90"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="16">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="16">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="16">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="19">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="18">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU81115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CBZ36336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP45862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="382" mass="42946" checksum="00F2A5D9CCDC73F1" modified="2019-04-10" version="1">MNVCSNTTKDPLTLMAMWGSMKGYNPEQGFSFEGPEKRLEVILRCTLETHVDGLRSLDDSVWSGVVGSLNAQIVSRESNECINSYVLTESSLFVMKNRIILITCGTTTLLNSIPNILEAISAVRGELEWVSFMHKNYSFPWMQKGPHTSLADEFATLKQHFPTGKPYIFGPVDSDHYFLFCYDDIIRPCSSEDDTQLSMTMYGLDKEQTKHWFSDRFISTSAETAAIRAATHLDRVVDGTWTLHDLQFEPCGYSINAIRDEEYQTMHITPEDHCSFASYETNSRAANYSDRMKKVLGVFRPQRFTVIVFLDPESPVGKAYNEGKGIGVEPEYYPEYNLLHRTTNEFAPGYVAMKINYVRTAAVEETDTAVGGAEPGAEGGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEN1</accession>
    <name>A0A3Q8IEN1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase zeta catalytic subunit</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LdCL_230023100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2120"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000336">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000031">
        <property type="entry name" value="Putative DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="2222"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="680"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="822"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1251"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1350"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1502"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1930"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1978"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2023"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2813"/>
            <end position="2867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1281"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1302"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1374"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1395"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="2041"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2831"/>
            <end position="2844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYU79043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3085" mass="328013" checksum="835438B46E340678" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEP0</accession>
    <name>A0A3Q8IEP0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_280024100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEP0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280024100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2520"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001527">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="211"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="584" mass="62658" checksum="478FDC057FDBABCD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEY7</accession>
    <name>A0A3Q8IEY7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330028000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEY7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330028000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3030"/>
    <dbReference type="OrthoDB" id="267168at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="573" mass="59136" checksum="F030DB02A5F2A32A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF73</accession>
    <name>A0A3Q8IF73_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_340007700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0400"/>
    <dbReference type="OrthoDB" id="273731at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU82358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1338" mass="148848" checksum="2B2A52125F594064" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFC5</accession>
    <name>A0A3Q8IFC5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L13, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">60S_ribosomal_protein_L13_putative/GeneDB:LmjF.29.2460/GeneDB:LmjF.29.2470</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L13e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_24825</name>
        <name evidence="9" type="ORF">CGC20_24830</name>
        <name evidence="10" type="ORF">CGC21_28765</name>
        <name evidence="11" type="ORF">CGC21_28770</name>
        <name evidence="12" type="ORF">CGC21_28775</name>
        <name evidence="5" type="ORF">LdCL_290031900</name>
        <name evidence="6" type="ORF">LDHU3_29.3820</name>
        <name evidence="7" type="ORF">LDHU3_29.3830</name>
    </gene>
    <organism evidence="5 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFC5"/>
    <dbReference type="SMR" id="A0A3Q8IFC5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3830"/>
    <dbReference type="OrthoDB" id="277928at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU80753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5431974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5431975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP50652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP50653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP52878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP52880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="220" mass="24747" checksum="719C4AF497ACBABB" modified="2019-04-10" version="1">MPKGNNAIPHVHQKKHWNPCSSQKGNVKVFLNQPAQKHRRRRLRLLKAKKVFPRPLKALRPQVNCPTVRHNMKRRLGRGFSPAELKAAGLNPQYAATIGIRVDSRRKNKSEEGMNVNVQRLKTYMSKLVLFPMNHKKVQKGEASEEEVKAATQDRSRFGDAAVGAVVYPSAETPRAVSAEEKSMCVYAFLKKNHSAVRFFGARSARAARKEAAKEEKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFL7</accession>
    <accession>E9BP27</accession>
    <name>A0A3Q8IFL7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_322760</name>
        <name evidence="10" type="ORF">LdCL_320033400</name>
        <name evidence="11" type="ORF">LDHU3_32.3460</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863689.1">
        <property type="nucleotide sequence ID" value="XM_003863641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFL7"/>
    <dbReference type="GeneID" id="13390977"/>
    <dbReference type="KEGG" id="ldo:LDBPK_322760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_322760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320033400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3460"/>
    <dbReference type="OMA" id="FHYLRRN"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5433033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="302" mass="36122" checksum="54C2B655828BF713" modified="2019-04-10" version="1">MMRRSSLLFSGGMVEYHEWHLHEPLLQNYEGWRILDNPKYEQKSDAYIYDFMGSVRHLDPIIDDPRLTHKQRVCRLYRWSLKEIQMWMIQLNAHKLNLAHKVIRRRFEKYRYVTDPATCDMMVRQTQKYLRDNANFHYMRRNNSSPWSTYTLANPMFHPDNSLVYDHWTHPEVMWYDDAKLHRWTAHHPLYAGPGEASERFGDMDVAPHLRGLVWAMFMSLFAWCFYQLLGGPGMRDDKHFEEWTQQFDENLAGALYAEERNSRSRNSVLRGDWDRILGVSSTLDGFYRNNLSVVDKANYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFM8</accession>
    <name>A0A3Q8IFM8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_6875</name>
        <name evidence="4" type="ORF">CGC21_35670</name>
        <name evidence="1" type="ORF">LdCL_300022800</name>
        <name evidence="2" type="ORF">LDHU3_30.2440</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFM8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2440"/>
    <dbReference type="OrthoDB" id="271002at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="165" mass="18732" checksum="A6F53B08234A9F96" modified="2019-04-10" version="1">MSLYSEIVSDQLPAAISAVKSHLAKQSPSQLARIVFTEFITFLRKYWAWAMYFIILRKLYRILSRTNKRSSKPNRIKRSSASIPDSKDSVADLVSTPRTVDIAFLTDTAEYAPSKNQMIVGDGVIVINRNDRYVEVYERKNVAKVGSVEAEVKALLKEFAARNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGI0</accession>
    <accession>E9BNC7</accession>
    <name>A0A3Q8IGI0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone chaperone Rttp106-like, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Histone_chaperone_Rttp106-like_putative/Pfam:PF08 512</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_320220</name>
        <name evidence="3" type="ORF">LdCL_320007100</name>
        <name evidence="4" type="ORF">LDHU3_32.0300</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863441.1">
        <property type="nucleotide sequence ID" value="XM_003863393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGI0"/>
    <dbReference type="GeneID" id="13390016"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0300"/>
    <dbReference type="OMA" id="PLENWGQ"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000670">
        <property type="entry name" value="Histone chaperone Rttp106-like, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000007">
        <property type="entry name" value="Histone_chaperone_Rttp106-like_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="2">
        <location>
            <begin position="337"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="527" mass="58212" checksum="F0B630D3DB0B2A68" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGK0</accession>
    <name>A0A3Q8IGK0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280005700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0100"/>
    <dbReference type="OrthoDB" id="271587at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1888" mass="215454" checksum="A713F373C4AFDBE9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGP9</accession>
    <name>A0A3Q8IGP9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_320006600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGP9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0250"/>
    <dbReference type="OrthoDB" id="249149at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10144" checksum="978027B3ADD61A34" modified="2019-04-10" version="1">MLSTTRYACCASAAAGKKFSFSEKMQRLQADPEHALSGPEYAFMRDRLAEYRKLQQTYAVKQTEVERARKAANMCGLEFTGKGSPSRIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHH8</accession>
    <name>A0A3Q8IHH8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_290032900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHH8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290032900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3950"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001310">
        <property type="entry name" value="Putative serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU80763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="501" mass="56214" checksum="1BD8A97BEF273929" modified="2019-04-10" version="1">MAQVAEESRALESLVFRNKYRQIKSIGKGSFGEAVLVRSKSDGKRYVAKAIDSISMTPKERRDVQNEIRILAAVDHPNIIRYHEHFEDDTLIFIIMEYADGGDLSSRIKEAKKQDVPQPFDPNLAMFWFLQICMALKYLHDNHILHRDLKTANIFLTSKNVVKLGDFGISTILQNTMACAKTVCGTPYYFSPELCQSKPYNNKSDVWALGVVFYETLTLHRPFNAKTLKDLLKKILAGNYDPIPTTIPVEMRSLCASLLQVNYLQRPSINRILESSYVQSTLRSFSEDLARQVEKDRTDFEARKLSEREKHAQSSPVKEAVARMPQEPAKPQLSEREQMAMLRGMDREKMKAMLAKQAAEEKSAPKTAAAPEQMGHPDVDDDGDYIAQKKAMVQNTKEIVGKSNLGGHPEEFGDGPADSAPQVETITMANGRTVLASNVRDHLEAEMGSELLNCAVELYNSGMMSGLTNSEMQHELSELLGPKFAHNSNAITKLAVWEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIH3</accession>
    <name>A0A3Q8IIH3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_290006200</name>
        <name evidence="4" type="ORF">LDHU3_29.0190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIH3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0190"/>
    <dbReference type="OrthoDB" id="2117703at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056855">
        <property type="entry name" value="ATP-grasp_IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038752">
        <property type="entry name" value="IQCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465:SF0">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24923">
        <property type="entry name" value="ATP-grasp_IQCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IQCH-like ATP-grasp" evidence="2">
        <location>
            <begin position="446"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="830" mass="92079" checksum="4EB5A9ECBC5015E9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIJ5</accession>
    <name>A0A3Q8IIJ5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_350056300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIJ5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350056300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6750"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="9">
        <location>
            <begin position="405"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="584" mass="65348" checksum="10F22737F778D2BC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIU9</accession>
    <name>A0A3Q8IIU9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Memo-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360017300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIU9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360017300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1560"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.830.10:FF:000005">
        <property type="entry name" value="AmmeMemoRadiSam system protein B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="370" mass="41649" checksum="B6F6AC852D60893A" modified="2019-04-10" version="1">MKPHKQQRTCTKHPIPSHNTSATARHSSGRLFQNTVQPSATRMRFVRPATHAAPHGRGWYEAIPERLKVTIDDYFSEATHCYDEEGHECARMTGLIAPHAGMSYSGRTAAETFAVFRDYLYAKGSKGSELERIFILGPSHTKGFEGCELSAASAYETPFGRLRVDTAVVDRVITDLRKAGVGAATASRRTDEAEHSIEMETPYLSHILHYPPTTTGAPAQPAAGRVAIVPIIVGWTDRQDEKAICDVLKPYMDDARNFFIFSSDFCHWGERFSYTYHYKRSEYPNIGDSIIAMDHAAMELLEKRDLERWYAYLQMTKNTICGRAPISIGMQRWADEMNKARVKFVHYSQSNKCKDADDSSVSYAAAIIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ31</accession>
    <name>A0A3Q8IJ31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer row dynein-assembly protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_320013300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ31"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320013300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0970"/>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF26">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN ODA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="597" mass="65711" checksum="038B87FA340DF2DA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJP5</accession>
    <name>A0A3Q8IJP5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_21380</name>
        <name evidence="2" type="ORF">LdCL_320043900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJP5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323790.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320043900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4790"/>
    <dbReference type="OrthoDB" id="246054at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="437" mass="47274" checksum="9B4BBEB8DDA13659" modified="2019-04-10" version="1">MTTLPVLHLKATSLQNVTIAADLSDTTATLYTFLRSTPSAAETELALQPFLESLHAAPSSGRAALMRRPNHRLVQLLESVAVDGVFRCTPHVLPALARHSDRWLHRLGYPSMDGEAADSTAAVDSAAHAASGSRRSASPPTAAPFSFMRVRATDMHQYVDPYSAYEADYVGRQEAAHSAHVDAFASGEAHLPKNGSAAESSGLQHRDTAQPHEEASSVSAEVSALTVPGDEPQRSELAPSASHAATPAPKAALTSAPAIHPVLHLIANQVVQQQEEGEKTGRGSAEERAHPSSSHAVLDEKLQRLMAQLNEAETQLTDAMAEKEAAEQVWLPYYSRLKTSRMYVNELKSRLQSAASLYLLQRYERETLQQAHVGVAMESMSLQLVLRDVRARLEDEQRSSLTDDHQQATESDMLAQQLSAVLAVPAAASQRNAACHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJR5</accession>
    <name>A0A3Q8IJR5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enolase, putative</fullName>
            <ecNumber evidence="2">4.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320045100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJR5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320045100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5040"/>
    <dbReference type="OrthoDB" id="10009078at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="608" mass="63545" checksum="5DE8A4DB82878B79" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJV6</accession>
    <accession>E9BE07</accession>
    <name>A0A3Q8IJV6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">QA-SNARE protein putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">QA-SNARE_protein_putative/GeneDB:LmjF.19.0120</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">SNARE domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_9260</name>
        <name evidence="8" type="ORF">CGC21_19530</name>
        <name evidence="6" type="ORF">LDBPK_190110</name>
        <name evidence="4" type="ORF">LdCL_190006100</name>
        <name evidence="5" type="ORF">LDHU3_19.0120</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860190.1">
        <property type="nucleotide sequence ID" value="XM_003860142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJV6"/>
    <dbReference type="SMR" id="A0A3Q8IJV6"/>
    <dbReference type="GeneID" id="13386002"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0120"/>
    <dbReference type="OMA" id="CIQQVAK"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5429397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP41867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="229" mass="26069" checksum="98AA41861F38EF76" modified="2019-04-10" version="1">MPLENGEVLSRCVQQVAKACSDAQSSVKELGTGRDAIARDRLRRIRLLVQQCNSRVEELLSDAEPFLESLRQQYAQQKAVFELINAEATRRERQTFRQTDPASMREGDLDALEPQVTFCEARPLNVSEFHTEEAIQREKLQSAREVESDVMDLKMAYQEFHSLVHQQQESLDRVTNNVTESRSLIERGHDQIQGATRRQRSFRKIGCISGAVVIVIMTIVIIVVTVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILI1</accession>
    <accession>E9BRF5</accession>
    <name>A0A3Q8ILI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_343570</name>
        <name evidence="1" type="ORF">LdCL_340045100</name>
        <name evidence="2" type="ORF">LDHU3_34.5820</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864516.1">
        <property type="nucleotide sequence ID" value="XM_003864468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILI1"/>
    <dbReference type="GeneID" id="13387395"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340045100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5820"/>
    <dbReference type="OMA" id="TMRCESE"/>
    <dbReference type="OrthoDB" id="271988at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5433955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="285" mass="31214" checksum="82B5B0C0A95E5093" modified="2019-04-10" version="1">MERRSEWLASLRSTLPQFSKRSAAPLERGQAAAILGSAPRRTLEEAVSSHNTTSSLLLPSQWREQATQRLITTLHGIVPPLQVQQTDYFLCSLIHPSYVQVSTMRCESDALRRRVQQELRRTVCMPLELTMTGSKSLRLLRELTHYVEQGAAAAAASARARATLPAAPVAEKSEERYPSCGPASWSSYPLDASWPELNGADSTAFVQAFRRAGLESLVLYDKSFFAPSPTSTDINGTGSAEVSLAAFTALCGSIELVSGWSSLLQFVDRVAGEQRGLERTTDDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILM8</accession>
    <name>A0A3Q8ILM8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSP1 C-terminal conserved region containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360086300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILM8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360086300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9750"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF5">
        <property type="entry name" value="PSP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="151"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="241" mass="27073" checksum="DF7798471ACCE5E3" modified="2019-04-10" version="1">MLATLTDITNVQASLPQPPKGKVAAANVAHVSPATVRQSVAQHNPYKWQCLPAGTYSAAEMMADMEDACTLPVQELFQEKEDRAPPPPGGPPVCNTLVQFKCHQAEYVSSMVVDKGQYVVVQGDRGIDIGVVIRINTNSQKTYVERTGPVGSILRHATQREVDYWATDLKDAEAMAAAFCQAKARSHGLPMEIAYAEYQFDKKKLTFYYEARTRIDFVQLLKELYREYGCRIWMEKLRNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILT7</accession>
    <name>A0A3Q8ILT7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">60S_ribosomal_protein_L2_putative/GeneDB:LmjF.32. 3900/GeneDB:LmjF.35.1430/GeneDB:LmjF.35.1440</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Ribosomal Proteins L2, C-terminal domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_0305</name>
        <name evidence="16" type="ORF">CGC20_0310</name>
        <name evidence="12" type="ORF">CGC21_21505</name>
        <name evidence="13" type="ORF">CGC21_6245</name>
        <name evidence="14" type="ORF">CGC21_6250</name>
        <name evidence="7" type="ORF">LdCL_320046500</name>
        <name evidence="8" type="ORF">LdCL_350019300</name>
        <name evidence="9" type="ORF">LdCL_350019400</name>
        <name evidence="10" type="ORF">LDHU3_35.1890</name>
        <name evidence="11" type="ORF">LDHU3_35.1900</name>
    </gene>
    <organism evidence="7 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILT7"/>
    <dbReference type="SMR" id="A0A3Q8ILT7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320046500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.1900"/>
    <dbReference type="OrthoDB" id="268636at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5434166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5434167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP44417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP46403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP46404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="260" mass="28273" checksum="7896A12A83DA59E3" modified="2019-04-10" version="1">MGKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHEAGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNVLPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLPSGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRGVARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKAVKGAWHPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INI3</accession>
    <name>A0A3Q8INI3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CGC21_13030</name>
        <name evidence="1" type="ORF">LdCL_360020000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INI3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1840"/>
    <dbReference type="OrthoDB" id="258140at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TPP48256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="184" mass="20746" checksum="3B07A3B23D9CB72B" modified="2019-04-10" version="1">MYCTAAVPGVPSDGTFTQDPRLYRSQFTPAACSSCPLKVQEVLCAEMEARTRLVCDALTDFQRIVSLCVTERHGRWVMSVADGRPRSGWSCPKCGWTEDDVCTFSSHRQMRTSGEVYSETLLREPCLTPLCDEVELHGSQPHRCRYADDAAMRLGRQHVFQREYGSMLQRIKSASQGIQESVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8INS5</accession>
    <accession>E9BI17</accession>
    <name>A0A3Q8INS5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC21_31450</name>
        <name evidence="12" type="ORF">LDBPK_260050</name>
        <name evidence="11" type="ORF">LdCL_260005400</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861593.1">
        <property type="nucleotide sequence ID" value="XM_003861545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8INS5"/>
    <dbReference type="SMR" id="A0A3Q8INS5"/>
    <dbReference type="GeneID" id="13388838"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0060"/>
    <dbReference type="OMA" id="TQSYLRM"/>
    <dbReference type="OrthoDB" id="240895at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001108">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000878">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP41059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="296" mass="32433" checksum="DC4B8273D51DE516" modified="2019-04-10" version="1">MDKYALGPVIGEGQFGSVRMATVKATGQTVAVKLLHVPRLTEGIPHPVARELLIASRVASPFLVKTIEIAPYGSHMAVVMERCMEDLACVLRKCSPAHPLPLLLTQSYMRMLLTALHALHSSGILHRDVKPSNCFVAVDGCLKLGDFGLSRPLCSDMSHEVVSRWYRAPELLFGQRRYGGEVDLWAAGCVFAELLRGHGRPFFTGDGDISQIAKIFDVFGTPTGGTCSFYRQLPDWEKVSFEEKKGTGLRVLLPFVPPEALDLLTKMLALDPASRCSAAEALSHPFFALSDILLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQR9</accession>
    <name>A0A3Q8IQR9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_280028500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IQR9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282340.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3170"/>
    <dbReference type="OrthoDB" id="264404at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="912" mass="97372" checksum="29744C35F3CCC715" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITS9</accession>
    <name>A0A3Q8ITS9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330006100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITS9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0140"/>
    <dbReference type="OrthoDB" id="266685at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33403" checksum="CEF4CA031CBEC0D0" modified="2019-04-10" version="1">MPSTAAKVRFNASRMREHLLGDTSESGRSESSHSPSLEATLPPPHLVRDPCYGVCLVWRPVEEPPLPRCIHTASQALEGDAEATGYRDEPLACAAARRDATTSTAATALQLRSPPVKAQSPRKTIRARESPPRGQLLRRGKGGIDDVLRNAREAQRLFYTLQEHRLQAEYRRSQGSLRQELDQQRQYKCMVQLAEYQAELVNIFGHTMQDAVADSFFDDGSDSVLAALQRKRGEAPSTRSAFYSAKHRGHCSVAGSLGVGARRGSAERALPPAASTRESSVAQERHAFQRALEEVRGGRRCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ITT7</accession>
    <accession>E9BPV9</accession>
    <name>A0A3Q8ITT7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_330300</name>
        <name evidence="10" type="ORF">LdCL_330007900</name>
        <name evidence="11" type="ORF">LDHU3_33.0350</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863854.1">
        <property type="nucleotide sequence ID" value="XM_003863806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ITT7"/>
    <dbReference type="GeneID" id="13392251"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0350"/>
    <dbReference type="OMA" id="PWANCIV"/>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001781">
        <property type="entry name" value="WD domain, G-beta repeat, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU81995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5433208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="511" mass="55711" checksum="0F3298FDCF851E69" modified="2019-04-10" version="1">MAGGSQPHRKRPRQGVLVDPLSREIYQMVVRQLHHDGFLAAASAVCDATGVVVGNVEDEGDRLARVVAAGLSVNEMERRAEEEFQFTQVVERFLSASKLYMPLSLSSRWLVGRRCLRMRERFMSASLGGVVRDISFSPDGAYVACAGTNGLAAIFSLETIEDLSALDEARAANRARALDGSRDAGSFGSGETAPKGSAIRNANEVTELAMVRRFHEHTQSVEVMRFHPTKPIVLSGGREGILYLRNYAYPDSKVVLKIHDTVPIRDASFHPSGEYIVVAANHHLPRLINVRTEKVLTPPGTYASSTAHTGPQWESEDSGSTATSYRPTDRGAQHSAALSSVCFAPDGRTMMSTSLDGTWMLYDGVSGRVIYRAESAHSGVPVTSVVYSRTGNVVLTAGMDSTARLWDLRRLHATSRNYQSPEVTSFGEPTKCECRSIRAVFSANESHVHCHDSTLLAVHSYCVYTGAVDCTVTTQPSFMQRGLAASPWANCIVTGGDDSRLRLWTPAWLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVX3</accession>
    <name>A0A3Q8IVX3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neurobeachin/beige protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_360023500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360023500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2360"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="3469"/>
            <end position="3580"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="3627"/>
            <end position="3917"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="4129"/>
            <end position="4161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="940"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2315"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3101"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3993"/>
            <end position="4059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2315"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2338"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3101"/>
            <end position="3112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3113"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="4011"/>
            <end position="4026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4367" mass="467814" checksum="07FF6E3C99A49269" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IW35</accession>
    <name>A0A3Q8IW35_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_360036000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IW35"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360036000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4110"/>
    <dbReference type="OrthoDB" id="271885at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="591" mass="66311" checksum="485AA5424C5B2772" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IWE4</accession>
    <accession>E9BUP8</accession>
    <name>A0A3Q8IWE4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_19580</name>
        <name evidence="12" type="ORF">CGC21_14980</name>
        <name evidence="11" type="ORF">LDBPK_365400</name>
        <name evidence="9" type="ORF">LdCL_360061200</name>
        <name evidence="10" type="ORF">LDHU3_36.7220</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865654.1">
        <property type="nucleotide sequence ID" value="XM_003865606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IWE4"/>
    <dbReference type="SMR" id="A0A3Q8IWE4"/>
    <dbReference type="GeneID" id="13388540"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360061200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7220"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000005">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="106"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5435119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ38977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP48646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP49639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="209" mass="24088" checksum="780D04BE442DFDC4" modified="2019-04-10" version="1">MASIEIPPEDRQHIDYLADLFAVIVAIEQIEKANRRDLINQDQYDTTVRRLLEKYKNTVAHLQGARNPYFTTIDDFFDKYCARFLAARATIRDGPMSSPNENNARFLARQSVECSDHFITLLDSLRLQQTSVDVLNPPLGDLLQVLRKLGLSKEEFCVRLQNWQRRLDSMSAADMLDESAARDFAYDLDRGYACFKAFLESDPTLSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4Y3</accession>
    <name>A0A3S5H4Y3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_020006100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4Y3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0170"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001206">
        <property type="entry name" value="Exportin T (TRNA exportin)-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001414">
        <property type="entry name" value="Exportin T (TRNA exportin)-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="11">
        <location>
            <begin position="109"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="12">
        <location>
            <begin position="407"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU75611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128086" checksum="02285F660B2076C1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H516</accession>
    <name>A0A3S5H516_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 100 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_020012400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H516"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0850"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="539"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="708"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="817" mass="90795" checksum="86D6352C660B1EE1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H542</accession>
    <name>A0A3S5H542_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLD domain protein, conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030009300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030009300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0440"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF126">
        <property type="entry name" value="CONSERVED TLD DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1515"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1691" mass="177079" checksum="AED2324E6369099C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5I2</accession>
    <accession>E9B8E1</accession>
    <name>A0A3S5H5I2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15 20">ATP synthase F1, alpha subunit</fullName>
            <ecNumber evidence="15">3.6.3.14</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="16">ATP_synthase_F1_alpha_subunit_putative/GeneDB:Lmj F.05.0500/GeneDB:LmjF.05.0510</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">ATPase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CGC20_24350</name>
        <name evidence="23" type="ORF">CGC20_24355</name>
        <name evidence="24" type="ORF">CGC20_24360</name>
        <name evidence="20" type="ORF">CGC21_9490</name>
        <name evidence="21" type="ORF">CGC21_9495</name>
        <name evidence="19" type="ORF">LDBPK_050510</name>
        <name evidence="13" type="ORF">LdCL_050010000</name>
        <name evidence="14" type="ORF">LdCL_050010100</name>
        <name evidence="15" type="ORF">LdCL_050010200</name>
        <name evidence="16" type="ORF">LDHU3_05.0570</name>
        <name evidence="17" type="ORF">LDHU3_05.0580</name>
        <name evidence="18" type="ORF">LDHU3_05.0590</name>
    </gene>
    <organism evidence="15 26">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="19 25" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 26" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 26">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="28" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="27" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="15"/>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858238.1">
        <property type="nucleotide sequence ID" value="XM_003858190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5I2"/>
    <dbReference type="SMR" id="A0A3S5H5I2"/>
    <dbReference type="GeneID" id="13391369"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0580"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="274756at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000002">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000004">
        <property type="entry name" value="F-type H+-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="11">
        <location>
            <begin position="176"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="12">
        <location>
            <begin position="406"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU75955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU75956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU75957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5427307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAC5427308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAC5427309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CBZ31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP44061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TPP44062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TPP51849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TPP51850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TPP51851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="574" mass="62549" checksum="73A7B4C6E63C363B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5P9</accession>
    <accession>E9B8P9</accession>
    <name>A0A3S5H5P9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_similar)_p utative/Pfam:PF00642</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_060380</name>
        <name evidence="7" type="ORF">LdCL_060008900</name>
        <name evidence="8" type="ORF">LDHU3_06.0470</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858346.1">
        <property type="nucleotide sequence ID" value="XM_003858298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5P9"/>
    <dbReference type="GeneID" id="13391653"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060008900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0470"/>
    <dbReference type="OMA" id="GSRCKYI"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000068">
        <property type="entry name" value="Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5427419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44600" checksum="B0E08F5D434EEEC3" modified="2019-04-10" version="1">MSQLLPRLFPAFLLSPTDTLVSFPSAAMIPQRQKPGGRVKRHWQKKKSLYDEYLADSGDSEGTGADEEREETFECEQYCVHMDVNILIQQTVQNIVQSVCLEDPDGFAIFGDHELICFAAAVKHNSSIMSLQIRYLDVSDVSLIPLCKALEQHPSIRALDLSGTHGGEGTSKALRQLVCTNPNIIFMRLEDTIVNPKDASIIEKATRYNSMSCPDPNNNPFHLGLLRRMSAMDEEHKFHEQLHARPWLLGNGPSNQKRFKKTVLSTAASSHIGGEICAQFIQGRCPYGSRCKYIHPERTVALKNAVASSLYNRAEQSGGGDAVSTAFSTTSVSRQRLQSRLRPPAFMLKKPEQCEREQENYEISMESPPAEDAPSTQPPVSSWWVMSVTVVCCCVIIVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Q8</accession>
    <accession>E9B8R2</accession>
    <name>A0A3S5H5Q8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_060520</name>
        <name evidence="10" type="ORF">LdCL_060010300</name>
        <name evidence="11" type="ORF">LDHU3_06.0620</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858358.1">
        <property type="nucleotide sequence ID" value="XM_003858310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Q8"/>
    <dbReference type="GeneID" id="13391662"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060520"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0620"/>
    <dbReference type="OMA" id="GHRWSPI"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="9">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="8">
        <location>
            <begin position="253"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5427433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ31635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="545" mass="58155" checksum="1C637B273CC779D5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H627</accession>
    <name>A0A3S5H627_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_080005800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H627"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080005800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0110"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU76310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1133" mass="124248" checksum="08ABF113FA8EA67D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H652</accession>
    <accession>E9B9F3</accession>
    <name>A0A3S5H652_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small ubiquitin protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Small_ubiquitin_protein_putative/GeneDB:LmjF.08.0 470</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ubiquitin-2 like Rad60 SUMO-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_23225</name>
        <name evidence="6" type="ORF">CGC21_0400</name>
        <name evidence="5" type="ORF">LDBPK_080480</name>
        <name evidence="3" type="ORF">LdCL_080009700</name>
        <name evidence="4" type="ORF">LDHU3_08.0540</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812628">
        <property type="protein sequence ID" value="CAC5427697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799595">
        <property type="protein sequence ID" value="CBZ31892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000034">
        <property type="protein sequence ID" value="TPP49107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000057">
        <property type="protein sequence ID" value="TPP54977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858613.1">
        <property type="nucleotide sequence ID" value="XM_003858565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H652"/>
    <dbReference type="SMR" id="A0A3S5H652"/>
    <dbReference type="GeneID" id="13391977"/>
    <dbReference type="KEGG" id="ldo:LDBPK_080480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0540"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000408">
        <property type="entry name" value="Small ubiquitin protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="117" mass="12740" checksum="1E4E2BD0AFA87D33" modified="2019-04-10" version="1">MEHPEHTNQHPEGNNNTEAPAPVKAEAAAAVSAQQISLKVVNADGAEMFFKIKRGTQLKKLIDAYCKKQGISRGSVRFLFDGAPIDEMKTPEDLGMEDDDVIDAMVEQTGGCVVRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6Q8</accession>
    <accession>E9BBQ4</accession>
    <name>A0A3S5H6Q8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC/TSA family/Thioredoxin-like, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_4500</name>
        <name evidence="3" type="ORF">LDBPK_140190</name>
        <name evidence="2" type="ORF">LdCL_140006800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859391.1">
        <property type="nucleotide sequence ID" value="XM_003859343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6Q8"/>
    <dbReference type="SMR" id="A0A3S5H6Q8"/>
    <dbReference type="GeneID" id="13391388"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0250"/>
    <dbReference type="OMA" id="NGKIAWR"/>
    <dbReference type="OrthoDB" id="241436at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000460">
        <property type="entry name" value="Thioredoxin-like, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="199" mass="22406" checksum="57ECC04E305B59B6" modified="2019-04-10" version="1">MTDIDVKTYSDDASLGKEAPTIESAHPIKGEKITITEDKIYVLYFFNTFYRGADVCNDEFTTLSEEMADKAVFVAISTDADIAKTEKYLGKEIIDENTKKRLRLDPSHICYDEGKAVSKSYAEVSNLSVMSCPMAFVVKDGKVAWRQQFLQTHTVNQSNFREQLSRVLAGEELESNGPRPKVEMEEEEAEGMDGDMSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H705</accession>
    <name>A0A3S5H705_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_170010900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H705"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.0840"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002305">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="591"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="910" mass="97539" checksum="1F03EF7395B968C5" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7A0</accession>
    <accession>E9BFE5</accession>
    <name>A0A3S5H7A0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_34430</name>
        <name evidence="8" type="ORF">LDBPK_211590</name>
        <name evidence="7" type="ORF">LdCL_210021400</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860676.1">
        <property type="nucleotide sequence ID" value="XM_003860628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7A0"/>
    <dbReference type="GeneID" id="13386521"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210021400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1890"/>
    <dbReference type="OMA" id="RERMIPQ"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="359"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP49378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="483" mass="54048" checksum="72EE2935BE59420E" modified="2019-04-10" version="1">MPALSADAADTISLVRQLQLLDDNTIRLLEQLFTNRLNGELVTSLVDGREESLAVALFRLCAGTHAEHILGYSLRFLADLVYADRKIGAQLGRGDLVKEFGGHPASVLLQIASSHSESLGIANPAIYLAATALRYGEYEGNETAFKDFFALARHTFAPETLQVTDVAFTVQACVQLARRKDFRPLFFQASLVSCIPHLLTDIVSSDSAGIIQVIYETLLLSWLLSFEYEGLVLLVRERMIPQLHRVLQRVQKEKCVRVTLMTLLNMVEAERKYMNKLLNPSSEEWVDSRIYQLGRLHQSETPGQQISTFKKGPSLVAEMVSVGMIKTLSQVSRRKFGDEDINAMVDQLNAALEKSMQVLTSFSQYRGEVLSGVLEWTPVHTSTKFWKEKAVNVEDNGYEVLVALGKVLRESKDELTLAVGCHDLGEIIRYHPTGRNLLTLAPMAGVKECVMMLMSHPNPDVAKEALLCTQKIMVQRWEYMQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7H9</accession>
    <accession>E9BJ67</accession>
    <name>A0A3S5H7H9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Snf7_putative/Pfam:PF03357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_271350</name>
        <name evidence="3" type="ORF">LdCL_270020300</name>
        <name evidence="4" type="ORF">LDHU3_27.2080</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861988.1">
        <property type="nucleotide sequence ID" value="XM_003861940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7H9"/>
    <dbReference type="SMR" id="A0A3S5H7H9"/>
    <dbReference type="GeneID" id="13386722"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2080"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5431259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="215" mass="25320" checksum="CA166607192A7BBA" modified="2019-04-10" version="1">MGLTDLFRRETPQERIRMYKRQLDRTCRDLDRERNKLSTQERKIMMEMKKMAKQDQVDAVRIMARDLVRTRKYNQKMYRMRTQIQGVSLRMQTMQSSAQMADAMKGVTKAMRSMNKKMNIPEVQKIMREFEKQNEMMGMKEDMMNDAVDEVMDDDGMEEEETEQEIQKVMDEAGLEFRTKVGVTDTALPQKSTETQGETDEELDARLAALKASMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7J7</accession>
    <accession>E9BJU2</accession>
    <name>A0A3S5H7J7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CGC20_13025</name>
        <name evidence="20" type="ORF">CGC21_22550</name>
        <name evidence="18" type="ORF">LDBPK_282210</name>
        <name evidence="16" type="ORF">LdCL_280027200</name>
        <name evidence="17" type="ORF">LDHU3_28.2990</name>
    </gene>
    <organism evidence="16 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="18 21" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 22" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 22">LdCL</strain>
        </source>
    </reference>
    <reference evidence="24" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862320.1">
        <property type="nucleotide sequence ID" value="XM_003862272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7J7"/>
    <dbReference type="GeneID" id="13387056"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2990"/>
    <dbReference type="OMA" id="HDMSPDG"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAC5431604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CBZ35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP40420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TPP54351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="386" mass="41167" checksum="C5A3B70AED2BC6A7" modified="2019-04-10" version="1">MAQIIGTSPEDLRRAADALVQGKLVAIPTETVYGLGGNALIGSAVKSIYAVKGRPPTDPLICHVYTLDGARKLWDLKWDEGAVELACTIGAALWPGPLTIVCKASPTLPDCVTGGSGYVGARIPNNPITLKLLEMADVPVAAPSANTFGHVSPTTAQHVYDDLAARDPELLIIDGGQSAIGIESTVAKVEANDLVVVLRRGCITVSMIHRAIADRYPQTRVEIRDTRIMCDPAKAPMVSPGQLLTHYSPHVPSSLLTPGSLAALTASADVPVYVHRGKDVVPLCETVVLDFNGYLSRFRDTCLFYHDMSPDGNPEEGCYAVFDALRATETIKGAKGLVFPLISEWPHDKAKEDLLTAMEDRLFRAASGVTAVLINEAAPASARHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7K9</accession>
    <name>A0A3S5H7K9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_290014700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7K9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1380"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003907">
        <property type="entry name" value="ABC transporter-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="60"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="720" mass="79173" checksum="3B29290BDB58124B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7W9</accession>
    <accession>E9BR07</accession>
    <name>A0A3S5H7W9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_21415</name>
        <name evidence="5" type="ORF">CGC21_26340</name>
        <name evidence="4" type="ORF">LDBPK_342090</name>
        <name evidence="2" type="ORF">LdCL_340028600</name>
        <name evidence="3" type="ORF">LDHU3_34.3510</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864368.1">
        <property type="nucleotide sequence ID" value="XM_003864320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7W9"/>
    <dbReference type="GeneID" id="13392777"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3510"/>
    <dbReference type="OMA" id="FMHFNHR"/>
    <dbReference type="OrthoDB" id="269728at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ37686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP40114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="132" mass="14806" checksum="AE6BCABF2B90AB3E" modified="2019-04-10" version="1">MAVLDYLFYAGVLLLAHALYMAYSIREQLQASHHSHGHIPAISFGGHNVSITAMMVPITLEVLAGTLLGIAGFAHRHKMQDARLCDVTKYLRYDNQMNSGVGFIHFNHRGTVACKRDELKEECKPLVQKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H811</accession>
    <accession>E9BT42</accession>
    <name>A0A3S5H811_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeobox associated leucine zipper, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Homeobox_associated_leucine_zipper_putative/Pfam: PF02183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_355230</name>
        <name evidence="4" type="ORF">LdCL_350058100</name>
        <name evidence="5" type="ORF">LDHU3_35.6990</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865100.1">
        <property type="nucleotide sequence ID" value="XM_003865052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H811"/>
    <dbReference type="SMR" id="A0A3S5H811"/>
    <dbReference type="GeneID" id="13387978"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350058100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6990"/>
    <dbReference type="OMA" id="RLQHYEP"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5434553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9741" checksum="93BE0366A68DCAC2" modified="2019-04-10" version="1">MSYRSSEAKKEEFRKYLESTQVVDALTRVLVNLYEEEEKPEDPVDYIKRVLGGASSADYEALQQENARLRAEVESLKKQLSGQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPX7</accession>
    <name>A0A3S7WPX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070012800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPX7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0970"/>
    <dbReference type="OrthoDB" id="267702at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="581" mass="60849" checksum="E2CC7339AC122E0C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ21</accession>
    <name>A0A3S7WQ21_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal region of Chorein, a TM vesicle-mediated sorter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_070018300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_071330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.1580"/>
    <dbReference type="OrthoDB" id="271287at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2542" mass="276280" checksum="F28133E04B8820FA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRZ1</accession>
    <accession>E9BAZ7</accession>
    <name>A0A3S7WRZ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyoxalase II, putative</fullName>
            <ecNumber evidence="7">3.1.2.6</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Glyoxalase_II_putative/GeneDB:LmjF.12.0220</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_23915</name>
        <name evidence="10" type="ORF">CGC21_9945</name>
        <name evidence="9" type="ORF">LDBPK_120200</name>
        <name evidence="7" type="ORF">LdCL_120007300</name>
        <name evidence="8" type="ORF">LDHU3_12.0310</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812632">
        <property type="protein sequence ID" value="CAC5428263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000044">
        <property type="protein sequence ID" value="TPP43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000031">
        <property type="protein sequence ID" value="TPP44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859134.1">
        <property type="nucleotide sequence ID" value="XM_003859086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRZ1"/>
    <dbReference type="SMR" id="A0A3S7WRZ1"/>
    <dbReference type="GeneID" id="13390117"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120007300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0310"/>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF139">
        <property type="entry name" value="HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5428263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ32422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="295" mass="32573" checksum="82886AD0B1283C38" modified="2019-05-08" version="1">MRNYCTKTFGSAFSVTVVPTLKDNFSYLINDHTTHTLAAVDVNADYKPILTYIEEHLKQQGNADVTYTFSTILSTHKHWDHSGGNAKLKAELEAMNSTVPVVVVGGANDSIPAVTKPVREGDRVQVGDLSVEVIDAPCHTRGHVLYKVQHPQHPNDGVALFTGDTMFIAGIGAFFEGDEKDMCRAMEKVYHIHKGNDYALDKVTFIFPGHEYTSGFMTFSEKTFPDRASDDLAFIQAQRAKYAAAVKTGDPSVPSSLAEEKRQNLFLRVADPAFVAKMNQGNAHALMMYLYNACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW71</accession>
    <accession>E9BES2</accession>
    <name>A0A3S7WW71_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calpain cysteine protease family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cysteine peptidase, Clan CA, family C2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_29230</name>
        <name evidence="5" type="ORF">LDBPK_201230</name>
        <name evidence="4" type="ORF">LdCL_200016800</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860464.1">
        <property type="nucleotide sequence ID" value="XM_003860416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW71"/>
    <dbReference type="GeneID" id="13386251"/>
    <dbReference type="KEGG" id="ldo:LDBPK_201230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_201230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1540"/>
    <dbReference type="OMA" id="NNRWSFY"/>
    <dbReference type="OrthoDB" id="268518at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000058">
        <property type="entry name" value="Cysteine peptidase, Clan CA, family C2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000296">
        <property type="entry name" value="Putative calpain-like cysteine peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="Smp-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="173"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="687" mass="78298" checksum="1F00C011A37C511D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWB0</accession>
    <name>A0A3S7WWB0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_22730</name>
        <name evidence="14" type="ORF">LdCL_210007800</name>
        <name evidence="15" type="ORF">LDHU3_21.0300</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWB0"/>
    <dbReference type="SMR" id="A0A3S7WWB0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0300"/>
    <dbReference type="OrthoDB" id="268883at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000156">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000010">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="231"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU78491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5429763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP54753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="471" mass="51763" checksum="4E16DFA66C6653CE" modified="2019-05-08" version="1">MATRVNNLLSHIAIRDSDSEEMRYIKQRLALASLATQFTMSSEKMKQLTMYMIHEMVEGLEGRPSTVRMLPSFVYTSDPAKATGVYYALDLGGTNFRVLRVSLRGGKVDDRTDSKFVIPKSALVGDATDLFDFIAQSVKKMMSENAPDDLEKRVPLGFTFSFPVDQKAVNKGLLIKWTKGFSTKNVEGNDVVELLQASLRRVRVNVNVVALCNDTVGTLVARYFVDTDVQVGVIIGTGSNACYFERASAVTKDPAVSARGNAVTPINMECGNFDSKYKYALPITVYDDEMDAITPNRENQRQEKLVSGMYLGEISRRLIVHLAQLGCLPRGLVDGLCRPWAFESKHMGMIAADQMPGLQFTRELIKRIAGVDVTDMSDLHTIREACCLVRNRAAQQGAVFTAAPMLKTRTQGLATVAVDGSVYEKTPSFQRLYQECITSILGSTSNVKVVLQRDGSGVGAAMICALAANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYZ6</accession>
    <accession>E9BHK6</accession>
    <name>A0A3S7WYZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Complex 1 protein (LYR family) protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Complex 1 protein (LYR family), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Complex_1_protein_(LYR_family)_putative/Pfam:PF05 347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_8580</name>
        <name evidence="3" type="ORF">LDBPK_251020</name>
        <name evidence="1" type="ORF">LdCL_250015500</name>
        <name evidence="2" type="ORF">LDHU3_25.1300</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861432.1">
        <property type="nucleotide sequence ID" value="XM_003861384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYZ6"/>
    <dbReference type="GeneID" id="13388678"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251020"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251020.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250015500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1300"/>
    <dbReference type="OMA" id="NTYIMRR"/>
    <dbReference type="OrthoDB" id="268736at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP40718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="162" mass="18404" checksum="4AD34E239409DF20" modified="2019-05-08" version="1">MLRSSAPLCTLGGSIVHSKALVAPVSEVVIRDAGTHLPGIPHANRVCRSYRQWLKLAVLCPPSALCDLNEHAQMNERFVIILRQKFREGAALRDPDQIAVAVQSCERSLAMFRFLAADGAKRKFPEAKPRLNLHKMGFLEMGKLNYKQMVKEYWNTYVLRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ65</accession>
    <name>A0A3S7WZ65_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER-Golgi trafficking TRAPP I complex 85 kDa subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250022000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2070"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1750"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2270"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1676"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2301" mass="245457" checksum="4C6B78B77EE734E8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X393</accession>
    <name>A0A3S7X393_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300018500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1710"/>
    <dbReference type="OrthoDB" id="272946at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1781"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1990" mass="209877" checksum="BCA936B4A1CFC971" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3E5</accession>
    <accession>E9BLK3</accession>
    <name>A0A3S7X3E5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_35330</name>
        <name evidence="3" type="ORF">LDBPK_301100</name>
        <name evidence="2" type="ORF">LdCL_300016200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862823.1">
        <property type="nucleotide sequence ID" value="XM_003862775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3E5"/>
    <dbReference type="GeneID" id="13385530"/>
    <dbReference type="KEGG" id="ldo:LDBPK_301100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300016200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1430"/>
    <dbReference type="OMA" id="MRHWVWD"/>
    <dbReference type="OrthoDB" id="268958at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600677" evidence="1">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="250" mass="29138" checksum="6627071C73A72259" modified="2019-05-08" version="1">MRRLACLASATALSGLSVAATAANPAASTTVPARFIYTTWGSVPCEGWACNESWLKRITSQSEYRSFDFWHVPQTDVPAGLKLNAVERYLLSSLENDAARLLHVSWCEDFDSYWRDRVNSLEMLYKTIYTDDHLFYRYIFGNCTHKTAEKEHMLRKLNYLKNILFWACRTERCYTSIAKARYYVQRCVWNALERERYLCACVEAVDSFGKKVPEELRHKAMPELEVALVSMRHWVWDCPNGKRTFTRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3I6</accession>
    <name>A0A3S7X3I6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300028500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3I6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3120"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="138"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="433"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1003" mass="107980" checksum="0B6FB52F2127EAD8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3U3</accession>
    <name>A0A3S7X3U3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_300038600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3U3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300038600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4390"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003770">
        <property type="entry name" value="ATP-dependent RNA helicase DHR1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002147">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="543"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="455"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU81130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116056" checksum="AA9048DD39B759A9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X423</accession>
    <name>A0A3S7X423_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X423"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0210"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24188" checksum="CDE6C7DA69215CB1" modified="2019-05-08" version="1">MDTAAFTAERRSGGAPATATSPHAKAASRDDRGIPAALEAPLGTTSTSFPRPSPQWMRIQNSTRALHAWEAKYAVVEADAQAEMEAAVGGNAALTEDLQHLCREDALLSKDEAALRGEDGALQADGAAVDGQSRAAAAQALVAASTNARRRQALREAQREFAQTQARHADSLHSLTAEMRQVEASTAGAEAQAQLLVQLIADKERKLALDTDSIRSRERDRLAPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4L3</accession>
    <name>A0A3S7X4L3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310024500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4L3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310024500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2980"/>
    <dbReference type="OrthoDB" id="252244at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="709" mass="76121" checksum="0D8B3D7DADF6CDE2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4T0</accession>
    <name>A0A3S7X4T0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310032800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4T0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312480.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310032800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4460"/>
    <dbReference type="OrthoDB" id="273570at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1226" mass="132971" checksum="2F4776894A8F7A4D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X5W6</accession>
    <name>A0A3S7X5W6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_320033800</name>
        <name evidence="3" type="ORF">LDHU3_32.3520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X5W6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320033800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.3520"/>
    <dbReference type="OrthoDB" id="267508at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5433037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26198" checksum="698E9FEA68C1FD74" modified="2019-05-08" version="1">MAATPPALLLAEEQRRLLDQFEFHVIQERGDTSVVWVGSAMRSGPTSTNNGSVSGTTPSSSASSGTSSPFACAPSVAPSKAVPPDSEQVARVTRFDLTAPHGGGRVPPLTGAKCDPLQRMEPAQSGVAMNSRAQELEAPTPPSLHVIAAAPLLHDNLSIRKGDLASPVTGVSVSSSHQPSRGWRTHVGGDSAVPLGELLRHVDADALTGATQTSVDEKCKELAERLLRMSAEADAVALAMNHDVVSPLEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6N3</accession>
    <name>A0A3S7X6N3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_330021900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6N3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2290"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="536"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="678" mass="71431" checksum="49AE83A0404D315E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6Z0</accession>
    <name>A0A3S7X6Z0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330027700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6Z0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330027700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3000"/>
    <dbReference type="OrthoDB" id="267698at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="541" mass="55114" checksum="8FA70E9BA555552F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7Z6</accession>
    <accession>E9BR15</accession>
    <name>A0A3S7X7Z6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_21375</name>
        <name evidence="3" type="ORF">CGC21_26380</name>
        <name evidence="2" type="ORF">LDBPK_342170</name>
        <name evidence="1" type="ORF">LdCL_340029400</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864376.1">
        <property type="nucleotide sequence ID" value="XM_003864328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7Z6"/>
    <dbReference type="GeneID" id="13392785"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340029400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3620"/>
    <dbReference type="OMA" id="PYNGQLK"/>
    <dbReference type="OrthoDB" id="275869at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="334" mass="38382" checksum="7B1F36EE6EF39FD6" modified="2019-05-08" version="1">MLRKSGRRLALEGERQFFYPGNSPMQSTGGLPFYGNLYAGRVDSQNYVPPRQGGSGLLEVDKSLWDNPATRQKLQSCPYFALSDQVMFHNMDPVYLDPGLLSPEEHQLLLLFSRAYYEKWAAIHRRPPHALPRLRITYGSSKLLDEILFLLDVHPDVCEVLKKEYAVDDSTLIGMNPNLWSSAYLDPANMDHLSGRVLEFAGVPEPKRKKFFLLLDQMRRIKVHRRDLPNGEERTDVVPFCYGVTLYDFCKFLGITPYSGQLKVYDYVDLQGTARSETLKDEDSYFDYLVALFYRADVRSATLTDLADASDHTCRYTVTVEPFTTADRRVGRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8A9</accession>
    <name>A0A3S7X8A9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_340041200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8A9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340041200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5410"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1209" mass="131122" checksum="0EF3AF33B806B0BA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9X6</accession>
    <name>A0A3S7X9X6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350047900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9X6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350047900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5670"/>
    <dbReference type="OrthoDB" id="267088at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="742" mass="77581" checksum="C5625342383A5FB3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBS9</accession>
    <name>A0A3S7XBS9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360061700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBS9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360061700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7270"/>
    <dbReference type="OrthoDB" id="272437at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019088655" description="MRH domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27949" checksum="A96CDE801E0D4878" modified="2019-05-08" version="1">MGCRSSCMLWLAVAALAVLTLQLRSAAAAPMDLSNPVEHNHFLLLAPYGASHRSGAGADGENTARYVQLSNGSRFVCETASTKRREPLDAKSYPLRHQMESLMTVMRRSDHPCVHYAEENYVTVYCWDNEVREDALSENKGRSLGRRRIDGPQIYWTSNDAFGRYVATVYGDGDECPYDKGRRIETEVRFHCRYSEFENPIPYMSLHESSQCRYMLRLLSSKFCSVPQLDHPSEEETVRCQMLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8N0</accession>
    <accession>A0A3S7WPD9</accession>
    <name>E9B8N0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_060190</name>
        <name evidence="2" type="ORF">LdCL_060006800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858327.1">
        <property type="nucleotide sequence ID" value="XM_003858279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B8N0"/>
    <dbReference type="GeneID" id="13391712"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060006800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0230"/>
    <dbReference type="OMA" id="LEHEWAW"/>
    <dbReference type="OrthoDB" id="273896at2759"/>
    <dbReference type="PhylomeDB" id="E9B8N0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="587" mass="61736" checksum="F855C9BD20E0AE9E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>E9BA77</accession>
    <accession>A0A3Q8I8M2</accession>
    <name>E9BA77_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_100290</name>
        <name evidence="9" type="ORF">LdCL_100008200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858868.1">
        <property type="nucleotide sequence ID" value="XM_003858820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BA77"/>
    <dbReference type="GeneID" id="13392207"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100008200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0420"/>
    <dbReference type="OMA" id="HPAGLPY"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="PhylomeDB" id="E9BA77"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="448"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="929" mass="98200" checksum="81B6B3FF2080C1D3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>E9BAT0</accession>
    <accession>A0A3S7WRQ6</accession>
    <name>E9BAT0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUB domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_110920</name>
        <name evidence="3" type="ORF">LdCL_110014700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859068.1">
        <property type="nucleotide sequence ID" value="XM_003859020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BAT0"/>
    <dbReference type="GeneID" id="13389542"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1140"/>
    <dbReference type="OMA" id="YFGEQQS"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="PhylomeDB" id="E9BAT0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="174"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="620" mass="66541" checksum="DD4311FE1C66BA67" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBU3</accession>
    <accession>A0A3S5H6R6</accession>
    <name>E9BBU3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_140580</name>
        <name evidence="6" type="ORF">LdCL_140011300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859429.1">
        <property type="nucleotide sequence ID" value="XM_003859381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBU3"/>
    <dbReference type="GeneID" id="13391414"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0810"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="PhylomeDB" id="E9BBU3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002401">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="852"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1174" mass="126899" checksum="9BC7BCB44355111C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>E9BC99</accession>
    <accession>A0A3Q8IA19</accession>
    <name>E9BC99_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_150580</name>
        <name evidence="3" type="ORF">LdCL_150010900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859583.1">
        <property type="nucleotide sequence ID" value="XM_003859535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BC99"/>
    <dbReference type="GeneID" id="13392931"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0730"/>
    <dbReference type="OMA" id="EWVCQAC"/>
    <dbReference type="OrthoDB" id="10258312at2759"/>
    <dbReference type="PhylomeDB" id="E9BC99"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038929">
        <property type="entry name" value="CCDC13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31935:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="542" mass="57391" checksum="802D67AB6798A3D0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>E9BE61</accession>
    <accession>A0A3S5H758</accession>
    <name>E9BE61_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_190660</name>
        <name evidence="9" type="ORF">LdCL_190011600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860244.1">
        <property type="nucleotide sequence ID" value="XM_003860196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BE61"/>
    <dbReference type="GeneID" id="13386056"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0740"/>
    <dbReference type="OMA" id="MFPEVVF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="PhylomeDB" id="E9BE61"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000027">
        <property type="entry name" value="DNA-directed RNA polymerase, alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="442" mass="47428" checksum="6FC6EB007AABF5D1" modified="2011-04-05" version="1">MSKPRRDVNKVQIGYHRAENTETVSSPHTYAYSSGKSVPSTTKPDKPTVSNIRIASAVAGLPPSRFAANAPVKREKNDEESESATAAASSASSSLLHGAASEARTTVDGFPWSTRRVERMSFEMQNVSPPISNLFRRVLTTEVPTLAFDRVLIEENDSPVLDELLSHRLGLVPVAGPVMKMHYITESNQASFSNLDPSRVLLFELDATGAKDAAVTPVYSRQLQWVPLPGQDKKTGAVAGACQTGREEYAGAAGATEHSADDDDDAVFLVHPDILLSKLGPGQRIKLKAIAVKGLGAVHAKWSPVSACYYEMKTSVELCERLTGSAAEALVKSCPAGVFGYEGGQKGAAATVVAPEKCTLCRECLRSDGKGAEAAASEGDRVRVQKEKTHVLFHIESVGQLHPAQILRFGLRLFAERCRALAEMVQSTEVRVADASAKSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFH3</accession>
    <accession>A0A3Q8IBZ9</accession>
    <name>E9BFH3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_211870</name>
        <name evidence="16" type="ORF">LdCL_210024400</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860704.1">
        <property type="nucleotide sequence ID" value="XM_003860656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFH3"/>
    <dbReference type="GeneID" id="13386466"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210024400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2240"/>
    <dbReference type="OMA" id="YVDHFEH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="PhylomeDB" id="E9BFH3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000172">
        <property type="entry name" value="serine/threonine-protein kinase Nek1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="358"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU78652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="800" mass="89873" checksum="B18E53D4604D4D3C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHI1</accession>
    <accession>A0A3S7WYX7</accession>
    <name>E9BHI1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA repair protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LDBPK_250770</name>
        <name evidence="15" type="ORF">LdCL_250013000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861407.1">
        <property type="nucleotide sequence ID" value="XM_003861359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BHI1"/>
    <dbReference type="GeneID" id="13388653"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0970"/>
    <dbReference type="OMA" id="LLRYPFC"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="PhylomeDB" id="E9BHI1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000081">
        <property type="entry name" value="DNA repair protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.10:FF:000010">
        <property type="entry name" value="Putative DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000077">
        <property type="entry name" value="Putative DNA repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="12">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="791"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="925"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU79409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122451" checksum="7613E1CDEFD1FABA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIH5</accession>
    <accession>A0A3S7WZW5</accession>
    <name>E9BIH5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">40S ribosomal protein S33, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_261630</name>
        <name evidence="4" type="ORF">LDBPK_261640</name>
        <name evidence="1" type="ORF">LdCL_260022000</name>
        <name evidence="2" type="ORF">LDHU3_26.2050</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861749.1">
        <property type="nucleotide sequence ID" value="XM_003861701.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024329240.1">
        <property type="nucleotide sequence ID" value="XM_024473469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIH5"/>
    <dbReference type="GeneID" id="13388996"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261630"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2050"/>
    <dbReference type="OMA" id="QGQLFER"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="328" mass="37180" checksum="BE54E7CB1E042448" modified="2011-04-05" version="1">MEMSIEALVEGLAVLQQATALDFSGNVEGAVEMYIAAVTRLDAVAEMLPADLAETVKRNTEAIRRKIDMLRRSRWTREQTTLFPSFTTQFVPVPIPIEDYRVPRSPFSRVFWLMRLLRRSIHQGAFFTPSLYVSREVWMQDGCGASLRFVGAKIKYTSALCSAMEPLRSMTTLGDIEKTEMHLRKFVDVERELRSTLDSEIGQVKDAKPQKKSVWGALAKKAKLWTHQESNYDVCLTWASSALEQGQLFERWHIYFAQAVKGLSPVPPGIQLILDLLQHIGIQLYSGLCVFLLHDMTILVERYQSKCQKSVTRLLPVEPKLESGGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>E9BME8</accession>
    <accession>A0A3S7X433</accession>
    <name>E9BME8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_310260</name>
        <name evidence="6" type="ORF">LdCL_310007700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863116.1">
        <property type="nucleotide sequence ID" value="XM_003863068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BME8"/>
    <dbReference type="SMR" id="E9BME8"/>
    <dbReference type="GeneID" id="13385838"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310260"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310007700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0320"/>
    <dbReference type="OMA" id="VMRDMCC"/>
    <dbReference type="OrthoDB" id="66977at2759"/>
    <dbReference type="PhylomeDB" id="E9BME8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001737">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001780">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF111">
        <property type="entry name" value="RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="75"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="287"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="912" mass="103462" checksum="96DC64AC5086AFDA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMV1</accession>
    <accession>A0A3S7X4M4</accession>
    <name>E9BMV1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleosome assembly protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_311770</name>
        <name evidence="5" type="ORF">LdCL_310025000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863268.1">
        <property type="nucleotide sequence ID" value="XM_003863220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMV1"/>
    <dbReference type="GeneID" id="13389442"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310025000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3050"/>
    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="PhylomeDB" id="E9BMV1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="403" mass="44841" checksum="A4DCC3E998663812" modified="2011-04-05" version="1">MPSQVHVDPIARTGSDASEASSSEVDMVAVMTEMTVAERRRVYALQGLLKEYYEVRQRLRAEIAALANECAAENQKLFAVRKEIVTGARDITEEEMQRIGRTAAPTEPDKKEDAAPAKKGVKFVDPVDEKQNSALVKAAASPSGGIPAFWLTAMSNSEAVNSMITEKDRDALMHLTDIERGFVEGDPEKGDRLVFHFSPNEYFTNETLTKEYHTEYDEDHGEPRITDVVGCDINWKSSKKNLTVTVKQKKQRNKKTGQMRVVEREEPCESFFNFFSPPNPDDDDDEDGDDEDFLEQEMEMDVEVGTALTQAVVPRAIFYYTGEAVVETGKELREQYGFGNSEDEEDEESDSDKEDEDEDEAPAGASNFRNIVRQRGGGATPGGRGGRGGAVGQQPPQQECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPF1</accession>
    <accession>A0A3S5H7T5</accession>
    <name>E9BPF1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_324010</name>
        <name evidence="2" type="ORF">LdCL_320046100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863812.1">
        <property type="nucleotide sequence ID" value="XM_003863764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPF1"/>
    <dbReference type="GeneID" id="13391575"/>
    <dbReference type="KEGG" id="ldo:LDBPK_324010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320046100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5140"/>
    <dbReference type="OMA" id="PLWLWTH"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="PhylomeDB" id="E9BPF1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="916" mass="101215" checksum="940A9D0C1E89B4A3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ62</accession>
    <accession>A0A3Q8ITZ0</accession>
    <name>E9BQ62_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_331310</name>
        <name evidence="2" type="ORF">LdCL_330019300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863957.1">
        <property type="nucleotide sequence ID" value="XM_003863909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ62"/>
    <dbReference type="GeneID" id="13392352"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330019300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.1960"/>
    <dbReference type="OMA" id="RETYWKH"/>
    <dbReference type="OrthoDB" id="267979at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ62"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="569" mass="59787" checksum="8CA94ADF4F977C8D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BS33</accession>
    <accession>A0A3Q8IIX0</accession>
    <name>E9BS33_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain/ubiE/COQ5 methyltransferase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_351570</name>
        <name evidence="4" type="ORF">LdCL_350020600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864742.1">
        <property type="nucleotide sequence ID" value="XM_003864694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BS33"/>
    <dbReference type="GeneID" id="13387622"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2090"/>
    <dbReference type="OMA" id="IPEAIVW"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="PhylomeDB" id="E9BS33"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000349">
        <property type="entry name" value="Methyltransferase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF15">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="351" mass="40674" checksum="827BC75358448E3B" modified="2011-04-05" version="1">MSGDAAERASGSAVVNGAPSGHSATSEIQQRHKGFIEPSDDVVMETARKALAREGRDAIPEAIVWSWETTAPPILARGKQNIYDLTDDIPKHVKPFWYHEYYQQREYFRLQREKRPLKERIKLWAGVLTAMAVAGAVLTFFRVWVEQPREIRQLREELLQHTYGRVLELAAGHGQNIGAYPYAVHEVVLTDSNPQQLQAMRYRIPHTAYPKYDVKRVRSETLDNFKDGEFDCVVDMFGLCHLRDPVMALRQMQRVVKPSGMILLLEHGASPYPPVNWFLDYFAQQHKVNTHGCKWNSPIRQYLQESRLEVKEMRNMHYGTTYYVVAYPEVLEAYKDHEKEAEQVKERSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>E9BUU6</accession>
    <accession>A0A3S7XBU2</accession>
    <name>E9BUU6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin, N-terminal domain family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_365890</name>
        <name evidence="2" type="ORF">LdCL_360066300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865701.1">
        <property type="nucleotide sequence ID" value="XM_003865653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BUU6"/>
    <dbReference type="GeneID" id="13388588"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360066300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7800"/>
    <dbReference type="OMA" id="YKYVLLY"/>
    <dbReference type="OrthoDB" id="79090at2759"/>
    <dbReference type="PhylomeDB" id="E9BUU6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000245">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54346" checksum="476639AAB608C1F5" modified="2011-04-05" version="1">MTDAAARDAYTAYGVDLIRTAGLLLRTTPSTIYRASILFQRFEASVETHFRSQYISALDMPAYRNCLNEDLKRAQLELLAASSPTGSPSMTEKTRDAPSKPAYPAGVEYLVPNHVQLKMRTGLVPLVDLHAPLDYCIHHLSDHEDIMYLVAACLLIATKMEDPSTRIRAVVNVCMRLSLRRSGTPVNEQSKPSLARYEDFKACVVEAEEVVLHQLGFQTFVESPYKYVLLYLNILSEPASDDAQSGIGAVRGDPSAGANGTTRPRAAAVAKTARPPAALTQWMIRAVQVVNDLPRCRRLLAVPADALAIYAIQQSCPPDLTLPDKWSTAFGVSERLLKAISYRYGVYSSNSVGSRPATAALADARALSTVPLYRTVAERDQYNLAMEQLKVARETAAEASAKTSLSVSPAPPPPPSSSGAAGPLPASFANPASIEELRDLIGASLPSDAVHGASRRRSRHDDDENILVRRSKHEKRHHRRHNDDGELRRRRHHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q9N6B0</accession>
    <accession>E9BKP1</accession>
    <name>Q9N6B0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARL-3A</name>
        <name evidence="18" type="ORF">CGC20_25640</name>
        <name evidence="19" type="ORF">CGC21_28020</name>
        <name evidence="17" type="ORF">LDBPK_290950</name>
        <name evidence="15" type="ORF">LdCL_290015300</name>
        <name evidence="16" type="ORF">LDHU3_29.1300</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2000" name="J. Cell Sci." volume="113" first="2065" last="2074">
            <title>LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity.</title>
            <authorList>
                <person name="Cuvillier A."/>
                <person name="Redon F."/>
                <person name="Antoine J.C."/>
                <person name="Chardin P."/>
                <person name="DeVos T."/>
                <person name="Merlin G."/>
            </authorList>
            <dbReference type="PubMed" id="10806117"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MHOM/SD/00/Khartoum LSB51.1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2003" name="Cell. Microbiol." volume="5" first="717" last="728">
            <title>Abortive infection of Lutzomyia longipalpis insect vectors by aflagellated LdARL-3A-Q70L overexpressing Leishmania amazonensis parasites.</title>
            <authorList>
                <person name="Cuvillier A."/>
                <person name="Miranda J.C."/>
                <person name="Ambit A."/>
                <person name="Barral A."/>
                <person name="Merlin G."/>
            </authorList>
            <dbReference type="PubMed" id="12969377"/>
            <dbReference type="DOI" id="10.1046/j.1462-5822.2003.00316.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">MHOM/SD/00/Khartoum LSB51.1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 21" key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="9">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="10">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="AF185069">
        <property type="protein sequence ID" value="AAF25826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF187854">
        <property type="protein sequence ID" value="AAF29898.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862512.1">
        <property type="nucleotide sequence ID" value="XM_003862464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9N6B0"/>
    <dbReference type="SMR" id="Q9N6B0"/>
    <dbReference type="GeneID" id="13387250"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1300"/>
    <dbReference type="OMA" id="EGMEWVC"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000281">
        <property type="entry name" value="ADP-ribosylation factor-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAF29898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU80590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5431803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP50815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="179" mass="20211" checksum="A66224B85DCEBBCA" modified="2000-10-01" version="1">MGLLTLLRKLKKSETEPRMLILGLDNAGKTSILRKLSDEDPTTTQATQGFNIKSINCEGFKLNMWDIGGQKAIRTYWPNYYDEVDCLIYVVDAADRRRLEETAAELDTLLQEEKLREAPVLIFSNKCDLATALSPENVSTALNLHSLRDRTWSIQKCSAKTGEGLHEGLEWAVKNLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9R2</accession>
    <name>A0A3Q8I9R2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140006100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9R2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0150"/>
    <dbReference type="OrthoDB" id="273617at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="357" mass="37503" checksum="98752D0177F966DA" modified="2019-04-10" version="1">MSVPPPPPAAIPLPSLATAVPLPPSCVVPPPPSASAAPPPPPMATVPLPPAEATPPPPSAPLIPPPPASVIPLPQPPGINAAVSAAPPPPSAIAAAPLLPEASPPPPTSTVAPPPPVQAAPALAEPPPVQPISVEAWRTLEGATREPVPNLAATRYLAVEERVRDEVCRLFILSEYDVGTLMVNIVQSLQHVGRHDVGLLRNDNSTAFTITQSTAHARQGDTLVEQRRHAVADAIERINQAGSDAERAFAEVAQRVAATAPPVAPAKDAPTAAAPAFRKSAYELLMEQIAATRRGRSPQNRRIASPEERPKRAAGGAGCVEYPTSYNGSYLLRRYGGTYDPQRQYSHYRYYGFPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAC7</accession>
    <name>A0A3Q8IAC7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">2.4.2.10</ecNumber>
            <ecNumber evidence="5">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_160010500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="4"/>
    <dbReference type="EC" id="4.1.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAC7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0670"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000183">
        <property type="entry name" value="Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000058">
        <property type="entry name" value="Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375:SF1">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="15">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU77634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="457" mass="49739" checksum="7073218D4A7928C2" modified="2019-04-10" version="1">MSFFDLLNERAKRSLLCVGLDPRAKTAAAAVEECKRLIEQTHEYAAAYKPNAAFFEFFGAEGWAALSEVIRAVPAGIPVVLDAKRGDIADTADAYATSAFKHLNAHAITASPYMGSDSLQPFMRYPDKAVFVLCKTSNKGSNDLQCLRVGDRYLYEAVAERAEGPWNVNGNVGLVVGATDPVALARVRARAPTLWFLVPGIGAQGGSLKASLDAGLRADGSGMLINVSRGLARAADPRAAAKELCEEINAIRFAKGASVELAKALVDSHCVRFGNFTLKSGKSSPIYIDLRRLVTYPTIMRLVAREYAKVLRHYKFDRIAGLPYAALPIASAISNEMNVPLIYPRREAKIYGTKAAIEGEYKKGDRVVIIDDLVSTGETKVEAIEKLRSAGLEVVSIVVLVDRDMGAKAFLNKLGYDFEAVVGLHQLLPLWRKSNAITSQQEADVRAFLGQWKQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBT7</accession>
    <accession>E9BGE3</accession>
    <name>A0A3Q8IBT7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_17080</name>
        <name evidence="3" type="ORF">LDBPK_231290</name>
        <name evidence="2" type="ORF">LdCL_230020000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861022.1">
        <property type="nucleotide sequence ID" value="XM_003860974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBT7"/>
    <dbReference type="GeneID" id="13390222"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231290"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230020000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1690"/>
    <dbReference type="OMA" id="MVELHIF"/>
    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="48657" checksum="E61EA9B58865E95D" modified="2019-04-10" version="1">MVELHIFDFDGTIFFSPVADPNALAAALVASGDLGAEDAAAAAKRLHGELRCPVSSGGLGWYQSLSTLSPPAVPERPAEATWFVEPILTHMRAIVKTRNSLTKERRPNVGTHPAAATVDMPLIYVLTGRDVKYCDRIWTLLQQAGLDKEVEDVLLKPTETAGTVKYKLNRFFSLIQYHRPARVFYYEDRVEQGRVLLEGMRALEEVLYTDVSDKNNGIDSGGNGYWKADRVGVVTFDVTGGAAEDASTTTLPPLTALNTPQPAVVPCAERDGATCQGTDGRNAHLSPIASSLRTSPYSLLRDACYPVDRRALFGSSSPTDTLPEAKVSAALDQAERQARQWVERTVQFYNSKSACQDRGRGQGGRPAAGGKQSTAAVTTTASGSKADTAAVCDARALRTAVSFAVPPPFVFVMVLVPPALCGRSTSILSGEQLVAVLRTLEEEKRALENSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICE5</accession>
    <accession>E9BIR4</accession>
    <name>A0A3Q8ICE5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_32535</name>
        <name evidence="2" type="ORF">LDBPK_262530</name>
        <name evidence="1" type="ORF">LdCL_260031200</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861837.1">
        <property type="nucleotide sequence ID" value="XM_003861789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICE5"/>
    <dbReference type="GeneID" id="13389085"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3250"/>
    <dbReference type="OMA" id="KLWRECL"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="143" mass="16512" checksum="2B811E122FBD32BC" modified="2019-04-10" version="1">MSAAREDSAPCAVPSKLWRECLKQFDYGPDRPKGACEAHRTKFYDCVKDWTARTQHKSYSYTQFELPKSCGHEAEKLHQCMMMNMFEVSHCQRDMAVLKRCAARADPEVRKYLQDDEAIAGLENDIEEATGLKRLWYKAIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICN8</accession>
    <accession>E9BD11</accession>
    <name>A0A3Q8ICN8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial RNA binding complex 1 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_24635</name>
        <name evidence="2" type="ORF">LDBPK_161600</name>
        <name evidence="1" type="ORF">LdCL_160021000</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859844.1">
        <property type="nucleotide sequence ID" value="XM_003859796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICN8"/>
    <dbReference type="GeneID" id="13393223"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160021000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1900"/>
    <dbReference type="OMA" id="AFFGFWD"/>
    <dbReference type="OrthoDB" id="275939at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP51095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="62976" checksum="590632B2DDD49482" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICX1</accession>
    <name>A0A3Q8ICX1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260016300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICX1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260016300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1350"/>
    <dbReference type="OrthoDB" id="264964at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="428" mass="46630" checksum="B8003EB37522D4A7" modified="2019-04-10" version="1">MAERANARADNVSRLRALLQSCPAHERRKLFPKPHPHPRRDVWPPATPVDPPSRYPSASARIKKSAASDTYRFLSSAVIESVQQGASRRAAADTQDATDECSAKGPQEKGYYDSPCWYSAPPGTWMDATYFIAHQSNRWNSLFHDLYYIRNEPTAPLLRCPACVGQRLRDGVAAQPRSESASLSAPCAAAEVPPASSSSPLWMAPAELHRHLNFIHAGELFTPHELKLYNAQVLHELRYSCGLAPAPTPADGEIGTGVAPGVRKTQPARVILVADVANIELGSPGELLEMLLSPKLLRVFSDFPVAFCATHELFVPVISKTLHTLYQLARLHPASTLHVFFANTSLESGDLLTSSYLNDLLLASPRCAVPPVVLLTADLQQQRALKEVHGAPAHGIGNGGHVRWVKPLTAAQLVFDLYAALESSQSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICY9</accession>
    <accession>E9BNH3</accession>
    <name>A0A3Q8ICY9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centrin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Centrin_putative/GeneDB:LmjF.32.0660</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">EF-hand domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_33660</name>
        <name evidence="8" type="ORF">CGC21_19905</name>
        <name evidence="7" type="ORF">LDBPK_320690</name>
        <name evidence="5" type="ORF">LdCL_320012400</name>
        <name evidence="6" type="ORF">LDHU3_32.0850</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863487.1">
        <property type="nucleotide sequence ID" value="XM_003863439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICY9"/>
    <dbReference type="GeneID" id="13390299"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0850"/>
    <dbReference type="OMA" id="MIQFARS"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5432825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ36801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="209" mass="22960" checksum="14D1F71203705D1A" modified="2019-04-10" version="1">MSTAAKKGPRTGTNKSAKGSIVCAAPGTDAKHTAASSPFTPATLLEVPPEYKQQLRQAFDKFDDSGKGFIPAHEVVVALYALGYDVGSAELQQLLQEVGAAGAESIDFNDFYNVLVLKMSKKESKTESVRAFKQMDRDDKGYIGLEDLRSMSDSLHMNLTDDELSEMIQFARSVGYHTPAQGQSEFDARDMLAVSETEYLRLMKRANVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID23</accession>
    <accession>E9BH85</accession>
    <name>A0A3Q8ID23_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16690</name>
        <name evidence="4" type="ORF">LDBPK_242230</name>
        <name evidence="3" type="ORF">LdCL_240027900</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861312.1">
        <property type="nucleotide sequence ID" value="XM_003861264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID23"/>
    <dbReference type="GeneID" id="13391472"/>
    <dbReference type="KEGG" id="ldo:LDBPK_242230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240027900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2720"/>
    <dbReference type="OMA" id="HAWNGLV"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="326" mass="36602" checksum="1F5E6D925C17BC90" modified="2019-04-10" version="1">MASSSCSPYGHSTSTRDYLFRSLYLRREMLLLTTHGIASALTPAEEDEDERQPSVANSVGSTTSPLRDVLLLPPLYCLDGLSLTPSANDGPAFGVDPMLAPDHAWNGLVQVRSPSSPWHRGCFAFYVYFPSRYPFEPPIIELTGPLRSHPLVQERCLQHLDQLSGAGDHLSEISSCAAQRDSPAKDTSTATPSETVKRVFVPFEEVYSTIDPMRVSVMMVLIRHMRLIFLPAEWPSSWRSPSMETDRDSGGVNRVLARRDVERRSVTQEVLLLKPFEQYLGTEVMQHFLDVWKASEGDTGDDMTDTVTKYNADWYTREVLPHLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID45</accession>
    <accession>E9BNS8</accession>
    <name>A0A3Q8ID45_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">NAD+ synthase, putative</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_20425</name>
        <name evidence="8" type="ORF">LDBPK_321750</name>
        <name evidence="7" type="ORF">LdCL_320023000</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863591.1">
        <property type="nucleotide sequence ID" value="XM_003863543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID45"/>
    <dbReference type="SMR" id="A0A3Q8ID45"/>
    <dbReference type="GeneID" id="13390641"/>
    <dbReference type="KEGG" id="ldo:LDBPK_321750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_321750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320023000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.2210"/>
    <dbReference type="OMA" id="NKDEDFY"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000246">
        <property type="entry name" value="NH3-dependent NAD+ synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD/GMP synthase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ36906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP43686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="293" mass="32540" checksum="E29CFEC20A108420" modified="2019-04-10" version="1">MPVAPLHPELQRMLKENRRARAFDPGAWIEMKCAKLNDYMRRCGLKACVTSVSGGIDSAVVLAMCARAMRAHNSPIKKNVGLCQPIHSSDWALRRGKENIAACGATEVVVDQTALHTELVTLVEKAVGIDGGAFARGQLRSYMRTPTGFYVAQLLTQEGTPAVVMGTGNKDEDFYLGYFCKAGDGVVDVQIISDLHKSEVFLVAEVLGVPENTRHAAPSADLWEAQTDEDELGFPYDFVEFFTEWYLKQLETAKLEFLNSLSDEARDQFERYVAACELVHRRNAHKLQGQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID59</accession>
    <name>A0A3Q8ID59_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_250006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID59"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0220"/>
    <dbReference type="OrthoDB" id="263052at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23807" checksum="E18CECDCB308C217" modified="2019-04-10" version="1">MADAAGTLLLSLEVEAAAARNAELSQTIEMLQDEVLRLRRANASLLACDARHCPKVSRQPAEKPSATAGECRDESSAAADAREVFVILDDLLFEMADIRSRIIPDERVDLRPRAFDAETTVAAHATRCLEEARKLKEALVVKQHSVAVQVSELRRALGEQAEANQKQTAAAALQCTMLERKYAEMKRRYDEAVSRQDELLLNRVIQSPTQPSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDD2</accession>
    <name>A0A3Q8IDD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_270021200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDD2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270021200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2180"/>
    <dbReference type="OrthoDB" id="260455at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.110">
        <property type="entry name" value="GNAT acetyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042573">
        <property type="entry name" value="GNAT_acetyltra_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027365">
        <property type="entry name" value="GNAT_acetyltra_YdfB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31143">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31143:SF2">
        <property type="entry name" value="FR47-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12746">
        <property type="entry name" value="GNAT_acetyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="437" mass="47505" checksum="A2770CC365FD6113" modified="2019-04-10" version="1">MLANTRTPPFPVCLPTQTQTSKAYTTTARSDHRRIGRLCESNASLRGSSPAARTLPSPLSLKCDVNADGPCECARNSSVASRHDKGSVCCAWRGGGGGVWSRCSAPCQVRRTHATGAFTKQRAHFHHPRHAFFYLGRRCVYAFRFLFGSDLFSCANSVCRAHALTCRYSAAFTPVCYAYHQGDMPARKQESEAVKALFHYPCHSFIVRSALEGHMGQVTVRGSSAAATLRARITVGVFTVLAGAPDAELVSGITTSLVVPVQPEWIPLIEAHSPALKPYIRYPMVTATGSFDVRRLQQYAAACPAAYVIEPITEALAERTRKMKWSFDLCGNFRDAADFAARGIGFVALERATGNIAAGASSFAICDGGVEVEVDTAESHQRRGLALACSARLILECLKRGLYPNWDAHVPHSAHLAEKLGYTRGTPYKAYVEELPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDG4</accession>
    <accession>E9BHW5</accession>
    <name>A0A3Q8IDG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dullard-like phosphatase domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">NLI interacting factor-like phosphatase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NLI_interacting_factor-like_phosphatase_putative/ Pfam:PF03031</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CGC20_26275</name>
        <name evidence="9" type="ORF">LDBPK_252110</name>
        <name evidence="7" type="ORF">LdCL_250026900</name>
        <name evidence="8" type="ORF">LDHU3_25.2580</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">LdCL</strain>
        </source>
    </reference>
    <reference evidence="13" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTDSPL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861541.1">
        <property type="nucleotide sequence ID" value="XM_003861493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDG4"/>
    <dbReference type="GeneID" id="13388787"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2580"/>
    <dbReference type="OMA" id="GSRQRVH"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000015">
        <property type="entry name" value="CTD small phosphatase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="6">
        <location>
            <begin position="177"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP48836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="366" mass="39509" checksum="FD1270C93F3B8CD7" modified="2019-04-10" version="1">MDGERETNATPTSFFRGVSEKLESQQQEQQTSSSGRLTAASSSSINAMPASPYRGGGAGGGATPPSSATTTPTSTVTPVSTLITQVSQHAPSSLQQQRSAGGHTGGYGDSSGTDGSGNAHAGPRVAGGSTGGSTGSRQRVHATELVERARYIRNQPKNTSPIDASAHPSLLPEPLPAVRNKKCLILDVDETLVHSSYQNTGRYDVHLPIALDRDTHVNVYVAFRPHLHRFLEAVAPLFEVVIFTASLSTYCDPLMDSIDKQRILGSLRLFREHCSVVGTTYVKDLSLLGRNLEQVAIIDNSPIAYLFQQRNAIPITSWFDDSRDEELLRLIPVLEALAEADTVYDVLDNYNALLQLQQLHENSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDH6</accession>
    <accession>E9BPE4</accession>
    <name>A0A3Q8IDH6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_35245</name>
        <name evidence="8" type="ORF">CGC21_21450</name>
        <name evidence="7" type="ORF">LDBPK_323940</name>
        <name evidence="5" type="ORF">LdCL_320045400</name>
        <name evidence="6" type="ORF">LDHU3_32.5070</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863805.1">
        <property type="nucleotide sequence ID" value="XM_003863757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDH6"/>
    <dbReference type="SMR" id="A0A3Q8IDH6"/>
    <dbReference type="GeneID" id="13391568"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323940.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320045400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5070"/>
    <dbReference type="OMA" id="MSENEWR"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000006">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5433158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ37122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP43891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="99" mass="11800" checksum="5F2C6D7169B64922" modified="2019-04-10" version="1">MPAKPAQDFFSLDANGQREALIIIKKLQCKILYSDKYYDDVFEYRHVILPKDLARLVPTSRLMSEMEWRQLGVQQSQGWVHYMIHKPEPHVLLFKRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDU5</accession>
    <name>A0A3Q8IDU5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260016700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260016700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1390"/>
    <dbReference type="OrthoDB" id="266281at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1704"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1728" mass="181605" checksum="240020D0D70B3D7C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDX4</accession>
    <accession>E9BII1</accession>
    <name>A0A3Q8IDX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase subunit V, putative</fullName>
            <ecNumber evidence="1">1.9.3.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cytochrome_c_oxidase_subunit_V_putative/GeneDB:Lm jF.26.1710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_5300</name>
        <name evidence="4" type="ORF">CGC21_32150</name>
        <name evidence="3" type="ORF">LDBPK_261690</name>
        <name evidence="1" type="ORF">LdCL_260022500</name>
        <name evidence="2" type="ORF">LDHU3_26.2110</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5431006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP52043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861755.1">
        <property type="nucleotide sequence ID" value="XM_003861707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDX4"/>
    <dbReference type="GeneID" id="13389002"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2110"/>
    <dbReference type="OMA" id="MKRFCIP"/>
    <dbReference type="OrthoDB" id="256337at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP41199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="196" mass="22283" checksum="398C70DFB58D1CED" modified="2019-04-10" version="1">MKRFSIPTLAVVPFARTFFGKGWDNAALDTIYSSMLRKPEVNDRIRTQYASTMDPRDADVLRRLGEVSKENKTFIRVFLPPHLGDPHRLLKCYSLMAYPILDDKGGQLKVEMDGCKLDAFADPDDDYSKVVIPHMELVEYLAKSLLETMKWEATPRGAASLLESLYRGAEIPDHVFQTPAVIERLESYKDGNKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK6</accession>
    <accession>E9BJF5</accession>
    <name>A0A3Q8IEK6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein_phosphatase-like_protein/GeneDB:LmjF.27.2 320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_272250</name>
        <name evidence="2" type="ORF">LdCL_270029900</name>
        <name evidence="3" type="ORF">LDHU3_27.3400</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862076.1">
        <property type="nucleotide sequence ID" value="XM_003862028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK6"/>
    <dbReference type="SMR" id="A0A3Q8IEK6"/>
    <dbReference type="GeneID" id="13386811"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270029900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3400"/>
    <dbReference type="OMA" id="CLLHDRP"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000064">
        <property type="entry name" value="Protein phosphatase 2C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF843">
        <property type="entry name" value="PHOSPHATASE 2C, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="314" mass="34363" checksum="14D70C1518CFDC3E" modified="2019-04-10" version="1">MPLKGLSALKGNTQTILISPVRDKYSILMEDDKIRAGASSMQGWRSTMEDAHAVYLSLPNMPGNIRDEDCAIAAVFDGHCGSKFAQSCAANIRDWLTSTDAFKKGNFEKALKDAYCTGDVALHKAMPNELSGCTGNCVLIIQNHLYCANTGDSRAVLCRNGEAIALSEDHKPTNPAERERIMKAGGFVQAGRVNGILSLSRAFGDYAFKDMSLKPEQMAITVTPDVFHTELTPHDEFVIVACDGIWDMMTNEKAVEFVRNEVADHGDISLACERLMNACLASTPTSYGTDNMTIIILQFKSLFLKKVESKFSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFC6</accession>
    <name>A0A3Q8IFC6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_250021500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFC6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1960"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001431">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF106">
        <property type="entry name" value="NIMA-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="454"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU79494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="940" mass="100441" checksum="F35C48D1868699E9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGL6</accession>
    <accession>E9BPF8</accession>
    <name>A0A3Q8IGL6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_21525</name>
        <name evidence="2" type="ORF">LDBPK_324090</name>
        <name evidence="1" type="ORF">LdCL_320046900</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863819.1">
        <property type="nucleotide sequence ID" value="XM_003863771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGL6"/>
    <dbReference type="GeneID" id="13391582"/>
    <dbReference type="KEGG" id="ldo:LDBPK_324090"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_324090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320046900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5260"/>
    <dbReference type="OMA" id="HFYAYMK"/>
    <dbReference type="OrthoDB" id="270286at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18709">
        <property type="entry name" value="PIN_VapC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62385" checksum="1D8CFF43C73754F1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH18</accession>
    <accession>E9BP73</accession>
    <name>A0A3Q8IH18_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_34915</name>
        <name evidence="10" type="ORF">CGC21_21145</name>
        <name evidence="9" type="ORF">LDBPK_323230</name>
        <name evidence="7" type="ORF">LdCL_320038300</name>
        <name evidence="8" type="ORF">LDHU3_32.4090</name>
    </gene>
    <organism evidence="7 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863734.1">
        <property type="nucleotide sequence ID" value="XM_003863686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH18"/>
    <dbReference type="SMR" id="A0A3Q8IH18"/>
    <dbReference type="GeneID" id="13391260"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320038300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4090"/>
    <dbReference type="OMA" id="KWWFNKS"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5433081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TPP43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="308" mass="34995" checksum="47D5291C0B1B2467" modified="2019-04-10" version="1">MLTEILDIDEHLATLNRCENIGEADVKRLCLKAKEIFTSEENVHKIPAPCTIVGDIHGQFYDLLELFRVGGEIPDTNYVFMGDFVDRGYHSVESFLLLLVLKIKYSRRVALVRGNHESRQITQVYGFYDECLRKYGSINVWRYCTDVFDLLPLASVVEGKIFCVHAGLSPSIQTVDQMRSIRRNCEVPHEGAMCDLLWSDPEDIDGWGLSPRGAGYLFGGDVVCQFNETNKLDLICRSHQLVMEGYKAMFNDTLVTVWSAPNYCYRCGNVASILELDEHLNKNFKIFEAAPAEAREAGQRNEVPAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH58</accession>
    <name>A0A3Q8IH58_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KATNIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_260024900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2520"/>
    <dbReference type="OrthoDB" id="304622at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027859">
        <property type="entry name" value="KATNIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14652">
        <property type="entry name" value="DUF4457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KATNIP" evidence="2">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1815" mass="189085" checksum="C2FF7D2CFEB6026D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH71</accession>
    <accession>E9BAA5</accession>
    <name>A0A3Q8IH71_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_100600</name>
        <name evidence="2" type="ORF">LdCL_100012800</name>
        <name evidence="3" type="ORF">LDHU3_10.0920</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5428020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858896.1">
        <property type="nucleotide sequence ID" value="XM_003858848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IH71"/>
    <dbReference type="SMR" id="A0A3Q8IH71"/>
    <dbReference type="GeneID" id="13392223"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100012800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0920"/>
    <dbReference type="OMA" id="EHRSSEM"/>
    <dbReference type="OrthoDB" id="277025at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd23678">
        <property type="entry name" value="RESC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058722">
        <property type="entry name" value="RESC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26170">
        <property type="entry name" value="RESC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-editing substrate-binding complex 5 protein" evidence="1">
        <location>
            <begin position="60"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="431" mass="47774" checksum="F38A31D97A8F2A3A" modified="2019-04-10" version="1">MPRNRLVVACNASTAGRPAQSLALSVSLSTTLRSSTALALTKSLVNITTHRGSRHSLLHTAVRRYTNVLYRLPPTQTIPTHSPSGEEVDTELFVRQVQNFFEVLRRSQLIERFYEMKSCPYYECLFTNDLFFQHHDLIIPMPKHGREHRSAEISETIRYMRGWGATGDVNHVLQDVKGGRASGGDFISTTHGMLMGYGTSRTNKLSMMTLTGAIAPSEAAAEQARALCVEPIEMLPDSPPLSDVIAFAGQRTFVISDTEHGHNAAQQAVKRIQKVPWQIIKLEPGCSFFSHLGGVNYVYDVLCDQDFPLSMERLGESGMNPFPVEWSEPRKLGITMRSICMTARFTRGTMNAGGYANSRGHAASSFNYNSRDISKNSRLFVGGSRKHGDQMAPLAAQLEADEIQKPVHQPIPRYAAPMHRRGTVVPTEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH90</accession>
    <name>A0A3Q8IH90_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dual specificity protein phosphatase, putative</fullName>
            <ecNumber evidence="11">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_340027200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="11"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340027200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3330"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002139">
        <property type="entry name" value="Dual specificity protein phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001882">
        <property type="entry name" value="Putative dual specificity protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF524">
        <property type="entry name" value="SPECIFICITY PROTEIN PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="404"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="1225"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1382" mass="152525" checksum="FEA2D6F41EDDFF4F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHH5</accession>
    <name>A0A3Q8IHH5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_110015300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHH5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110015300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1180"/>
    <dbReference type="OrthoDB" id="273860at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="413" mass="42817" checksum="8BCAE5E61E148191" modified="2019-04-10" version="1">MPAASSSVGHVRGSASSMASNSTEGGFGTGAGGGADAERRPPPRLRYFFECFVPDEDASDAQSLSEVWRHMEPLNPFHYLELWCGVDGAAAAPTTAAGPGWVKPEPPAELNAFTDGDRVTDGSASKVEDNTAKKEAQDGALPCSPARITGGALITRAAQNALQRTLRTVGLPDELSCMVMLSARIPPGARLTRKQEKILRLRAQRRPPPPRPIRRGAKVFVPVPAVLVSAAENGMPAGSTRGGGGLLDVTALGPRVMRLAPAGFADAAAGVDSAGYSKVPSAVSVMGEFAFDDDDEDEKYFHSGRRAGMKRGRHGVEDERLDDGDAPLINSGRWGLDGSAGGGLGGSAGATAAAGAAGGAVTAQGDEVEEDRDEEDVFSTGMVDDDDDENMASEDDVQEDGESFGGDEGDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIG9</accession>
    <accession>E9BT02</accession>
    <name>A0A3Q8IIG9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_7830</name>
        <name evidence="11" type="ORF">LDBPK_354830</name>
        <name evidence="10" type="ORF">LdCL_350053300</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865060.1">
        <property type="nucleotide sequence ID" value="XM_003865012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIG9"/>
    <dbReference type="GeneID" id="13387938"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350053300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6350"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000054">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ38381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP44733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="354" mass="38456" checksum="ABB068390F49345F" modified="2019-04-10" version="1">MPNTYCYLDITIGGKPKRERVVLELFADVTPKTCENFRQLCLGNDGKKVEGTEVPMTYQGCTFHRVIPGFMIQGGDFTNHNGTGGVSIYGEKFEDENFTIPCDKSGLLAMANAGANTNGSQFFITTAPATHLTGRHVVFGRVVRGMNTVRAVEQTPTGANDKPVADCVIAGCGTLDALPEEEPASDGDMYPDYPEDAESPMVDAKRIEAGESIRQIGNSHFKNAAYDSAIEKYAKAVRYLNQVENKEVHPEVDAKLIACYNNHAMCAIKLQQWSEARHTASLALSVDAKNAKAFFRRGTAALKAGDADGAVEDLTQAHQIEPENAEITAKLSEAKEKVKAQKAKLAANLKKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIM0</accession>
    <accession>E9BC80</accession>
    <name>A0A3Q8IIM0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_1740</name>
        <name evidence="4" type="ORF">LDBPK_150390</name>
        <name evidence="3" type="ORF">LdCL_150008800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859564.1">
        <property type="nucleotide sequence ID" value="XM_003859516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIM0"/>
    <dbReference type="GeneID" id="13392916"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150008800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0490"/>
    <dbReference type="OMA" id="GARDMVC"/>
    <dbReference type="OrthoDB" id="266440at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="494" mass="54535" checksum="DEA7FA310D876FB2" modified="2019-04-10" version="1">MSSEVEELLARHQRRFAVYEEFLRTDNKTLPPPPRSPSPQQREQQRQHQTAPSEAVLSTHSVSGRDAHYVSGTSAGDHNEERVGRSRDRGGHSSPGARAPKTATTSTTSVADVARAIAAHGSPVEPTRSYASIEAGTPPSLQRRSTSRSPCDAHTTAAATSVARHRTSAGELDDIDYLIGERLRSAGRYRLALTPDAAYIKSQAWALRRDQVKEALRREQEDAKLRECTFRPQLGPAAMEGTRDAEAASNGSGGHCPDVGAVKVSVTEDPGVSQHLARLEKARRHRRETETRLNGSNAHHWTSRSTVPHEFQLGLRVAESIPSLRKPYMPITSLGGDLSTATSLQRHEREEIVKRASAAQRRRSFSSAPPSHVRDRRGSRPRSPLPTTTDAARRSVNGEQKKPRRQKGLPRTRQRFFSSTTLIPDAAHGEAYAPEPQRSCLEVGARDMVCYLTNQLTHKDAIIQEQVENLERLHRELDAAMETLHQIASLGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIR4</accession>
    <name>A0A3Q8IIR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350011600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0810"/>
    <dbReference type="OrthoDB" id="273888at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1546" mass="156865" checksum="EC1DE929550B21FD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJI5</accession>
    <name>A0A3Q8IJI5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300028600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300028600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3130"/>
    <dbReference type="OrthoDB" id="247078at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="853"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="940"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1304" mass="139629" checksum="32E7390DDD0DA13C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKJ6</accession>
    <accession>E9BNB5</accession>
    <name>A0A3Q8IKJ6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_33385</name>
        <name evidence="5" type="ORF">LDBPK_320100</name>
        <name evidence="3" type="ORF">LdCL_320005900</name>
        <name evidence="4" type="ORF">LDHU3_32.0160</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5432766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863429.1">
        <property type="nucleotide sequence ID" value="XM_003863381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKJ6"/>
    <dbReference type="SMR" id="A0A3Q8IKJ6"/>
    <dbReference type="GeneID" id="13390004"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0160"/>
    <dbReference type="OMA" id="EYCAFKR"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000317">
        <property type="entry name" value="NLI interacting factor-like phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5432766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ36743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="231" mass="27144" checksum="5FB83FF567F966E7" modified="2019-04-10" version="1">MADGPPRFFTKPEEYVGVNNHRRTLFLDMDETLVHCYFEKPTFFIDTNEDFFQFTLEDDPSVTYYAFRRPGLNEFLYQCAEHYDMRIFTAGEDLYARTLLRWLLPDNLIDESRWYTRDACVGDGYGRLIKNLSMLDGFQFEERTALILDDSAPDNVYPHQNALAIPRFAPQTGRTDEENYGRMQADRGLEMFGRMLCGEHFTRCDDVRVPIARFYALIRTYTRSSTAKSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKR6</accession>
    <name>A0A3Q8IKR6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340013000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKR6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340013000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1230"/>
    <dbReference type="OrthoDB" id="272469at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="768" mass="83946" checksum="2CA7E990FC40CE6D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILA8</accession>
    <accession>E9BFJ8</accession>
    <name>A0A3Q8ILA8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SET domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SET_domain_containing_protein_putative/Pfam:PF008 56</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_21910</name>
        <name evidence="5" type="ORF">CGC21_34670</name>
        <name evidence="4" type="ORF">LDBPK_212120</name>
        <name evidence="2" type="ORF">LdCL_210026900</name>
        <name evidence="3" type="ORF">LDHU3_21.2520</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860729.1">
        <property type="nucleotide sequence ID" value="XM_003860681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILA8"/>
    <dbReference type="GeneID" id="13386553"/>
    <dbReference type="KEGG" id="ldo:LDBPK_212120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_212120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2520"/>
    <dbReference type="OMA" id="PTACEDW"/>
    <dbReference type="OrthoDB" id="255786at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="198"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="385" mass="44009" checksum="E4BC822AAF7DA604" modified="2019-04-10" version="1">MSPVLVPTACENWSLNIDDESTRRFWWNNTYSITLWEETLNIEKQTETITDGDVWSKFIDLQLRCAFKICSICHSPEGNDDMKICCYCGNTVHENCSEPAAPEQIMWKPANLAYVEHMRACFQCQAVDYKEPSAPQSPSECDNARRAAKRALTISDEYPPATVERIQELLQQAETTSNDAVLLGELKSLVQSYFQSPQSLRFLRKERVASKGGGIGVVAAQKIPAFSIIGVYPGYLDFMSGEQAKCGRPVPKYALMEYNCANYFNEVFVELQTTFTPFINEPNVDEKSNCAWIQEPHRKNGRLSVICVRDIQEGEELTIGYGPIYPRTYPYCYDAYACHQIEGHATHPCYSLWHWPTLQEADARFVCYIGYIEKEDCYVLWKNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILE8</accession>
    <name>A0A3Q8ILE8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-Casp domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cleavage and polyadenylation specificity factor, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Cleavage_and_polyadenylation_specificity_factor_p utative/GeneDB:LmjF.34.3430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_20885</name>
        <name evidence="10" type="ORF">LdCL_340041000</name>
        <name evidence="11" type="ORF">LDHU3_34.5370</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000015">
        <property type="protein sequence ID" value="TPP46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILE8"/>
    <dbReference type="SMR" id="A0A3Q8ILE8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340041000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5370"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="8">
        <location>
            <begin position="258"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="9">
        <location>
            <begin position="489"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU82688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5433919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="756" mass="84041" checksum="702D06C1096B0DBB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IPL1</accession>
    <accession>E9BUN0</accession>
    <name>A0A3Q8IPL1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Delta tubulin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Tubulin delta chain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Tubulin/FtsZ family, GTPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_14890</name>
        <name evidence="8" type="ORF">LDBPK_365220</name>
        <name evidence="7" type="ORF">LdCL_360059400</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865636.1">
        <property type="nucleotide sequence ID" value="XM_003865588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IPL1"/>
    <dbReference type="GeneID" id="13388522"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360059400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6990"/>
    <dbReference type="OMA" id="QCVTRGE"/>
    <dbReference type="OrthoDB" id="10250004at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ38959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP48628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="562" mass="60096" checksum="69D36D35C99E6459" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISJ9</accession>
    <name>A0A3Q8ISJ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310018400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISJ9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1920"/>
    <dbReference type="OrthoDB" id="264571at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="629" mass="68717" checksum="336F30BB7D62D37B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVF4</accession>
    <accession>E9BSN0</accession>
    <name>A0A3Q8IVF4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">KH domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Pre-rRNA-processing protein PNO1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_7245</name>
        <name evidence="7" type="ORF">LDBPK_353590</name>
        <name evidence="6" type="ORF">LdCL_350040900</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864939.1">
        <property type="nucleotide sequence ID" value="XM_003864891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVF4"/>
    <dbReference type="GeneID" id="13387816"/>
    <dbReference type="KEGG" id="ldo:LDBPK_353590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350040900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.4710"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000082">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ38259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP44616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="221" mass="24473" checksum="0A412967D2BCD9F5" modified="2019-04-10" version="1">MFSEAVATVSSAGDGETKAPAAKTAAVPFVRETRSIKIPHHRFPPLKKVWMEVYTPIVEQCKLEIRMNLKTRSVDLRTSPSTSTAEGDQSGNASKVMLQKAEDFVKAVIAGFDVRDAVALLRMDDVYIEGFEIKDVRANLQGDNLSRCIGRISGSHGKTKYTIENVTRTRIVVADTKIWIMGTTQNIRVARDAICDLIRGSPASKVYTRIRAVMNRVNNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IVL2</accession>
    <accession>E9BT07</accession>
    <name>A0A3Q8IVL2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase (Branch 1) family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily (Branch 1), putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Histidine_phosphatase_superfamily_(Branch_1)_puta tive/Pfam:PF00300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_14350</name>
        <name evidence="5" type="ORF">CGC20_15940</name>
        <name evidence="6" type="ORF">CGC21_7855</name>
        <name evidence="4" type="ORF">LDBPK_354880</name>
        <name evidence="2" type="ORF">LdCL_350053800</name>
        <name evidence="3" type="ORF">LDHU3_35.6400</name>
    </gene>
    <organism evidence="2 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000047">
        <property type="protein sequence ID" value="TPP44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865065.1">
        <property type="nucleotide sequence ID" value="XM_003865017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IVL2"/>
    <dbReference type="GeneID" id="13387943"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350053800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6400"/>
    <dbReference type="OMA" id="LWFRAFF"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF33">
        <property type="entry name" value="PEPTIDASE S54 RHOMBOID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044599621" evidence="1">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP47856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="335" mass="36523" checksum="8C10E16892FFC863" modified="2019-04-10" version="1">MFFWMVVALLVAIAIVVTPAGKLAAAKCQLYAHGVVFMAKAEDLPKAYRGTNYIRMNTVGDGTGGKRMIRVIFIRHGQSVWNSLFNSCNLGLPVRVAKAAAREFTDFFTNPFGSCIIDSPLSSKGKREAQDLASFMRTAKTKISFDPRTSVVVSSNLRRAMETALIGVSPRLTVTQERIVMDSSLQEGSQNIDAQSLSTEPGKIAPCKLGTITHPLELAVVFDPYLNAGNRVAGVDVYQRMDEFIMHLFGGSGEANLVPAAGGSNAALKEVIVVGHSGYFRSFFRRFLPPHSTHISKKSKMQNCAVVAFELTRDESSDEVAVEESTLKVLYKGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H4W0</accession>
    <name>A0A3S5H4W0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_010010800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H4W0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0660"/>
    <dbReference type="OrthoDB" id="273214at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="2">
        <location>
            <begin position="456"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="624" mass="67598" checksum="41D1DA5AD9F5D0CD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H590</accession>
    <accession>E9B7Z1</accession>
    <name>A0A3S5H590_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_040250</name>
        <name evidence="6" type="ORF">LdCL_040008000</name>
        <name evidence="7" type="ORF">LDHU3_04.0320</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812624">
        <property type="protein sequence ID" value="CAC5427159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858088.1">
        <property type="nucleotide sequence ID" value="XM_003858040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H590"/>
    <dbReference type="SMR" id="A0A3S5H590"/>
    <dbReference type="GeneID" id="13390699"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0320"/>
    <dbReference type="OMA" id="AEADICT"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU75804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5427159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28039" checksum="D2F44AC708F9723C" modified="2019-04-10" version="1">MALPSPTSSASAPPSSRDKASYCLQQAQAAKAAGNAALQAGNPRGASFEYKKVYLYLAEYLPSDVAQSASSVALGYSNGGGSNADGNSGLVQMLQQQQRRKQPKNVAAAAVTGHESSASPSTAEEAALLKLQEEMTQLYATTLNNLALAHMKLGRYQEGVKCATAVLEQPALRAALDAGAEQCTSARFSDTPAGKALLRRAACYVKLSDWALAEADIRTLRRATPEGAPAASGGDALDTAVVQLTQAVEQGRKAEAAKEKKMMRLMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5F9</accession>
    <accession>E9B8A2</accession>
    <name>A0A3S5H5F9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_24530</name>
        <name evidence="4" type="ORF">CGC21_9310</name>
        <name evidence="3" type="ORF">LDBPK_050120</name>
        <name evidence="1" type="ORF">LdCL_050006100</name>
        <name evidence="2" type="ORF">LDHU3_05.0150</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000038">
        <property type="protein sequence ID" value="TPP44025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000058">
        <property type="protein sequence ID" value="TPP51885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858199.1">
        <property type="nucleotide sequence ID" value="XM_003858151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5F9"/>
    <dbReference type="GeneID" id="13391349"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0150"/>
    <dbReference type="OMA" id="CESMFAC"/>
    <dbReference type="OrthoDB" id="249874at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000564">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU75917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5427269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP44025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="338" mass="37791" checksum="9E4E301EE75C3237" modified="2019-04-10" version="1">MLRRTSRQLRPVAAVGLAVVGAGDGTRQRNSLQRLLRDHDEGVAANAKGTITVTSTYDVESALYYDQYNMAVMPCVSGGAARQALRAKLIESGAVAGVRERLLAPWQAEGERRVVVFGCRSVAYLKRQLLADTTHSFLIVDPSLKELMGAAAALTPAFARRVFFLRCESMFTCLQVLQPETADVAVVPMPVPFWSKHGSHRRLVHFDFYCAAHSVLRVREAPTDPRGVVLFTDCEPYAAFMMEHLEEAKLVVPYTRKNPAQLFQRWLPQDELIEDVEGGAQRRRREFPKQRDEDVVALAAAKSGATTPDARRLLSAYNYSRKYYRDFAEERVQQAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5L6</accession>
    <name>A0A3S5H5L6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_050015900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU76012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5L6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_051060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.1180"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="478" mass="55221" checksum="286C9E3723243FD0" modified="2019-04-10" version="1">MLRRASVLLSLRPSEAYRQLVLRGDISTDENQISALPVFDRLYDDLVKYTKESKRIGVPKRQVELRPPNRLGIIPSLFLRREQEKKVEQALSDDNKAVYHPLSHVKGLYVWGGVGCGKTMLMDLLYDNAPPEIRKRRLHFHQFMLDMQKTSNSIRYKSKEEMQDPANRTNMVRYNISDNRRRTPDAEINLFDEVAQRMISDVELLCFDEVAVSDVAHAMILKRLFHSFYKIGLVVIFTSNRPLEDLYKDGLNRGGFIPFIDLVKKQCVIHHMKSNVDHRLLGHQADTYLTPMSSENNSKFQKLFLEMCKAMPATERKLEVFGRDVIVPRACGGVCYFHFYELCGGEKSAADYEVIAKTFHTIFINGVPQFPYENSDVKSRFLLLIDTLYGHRCKVMIHAAVEPPQLQAPKEEAAGRIEGDAQRFDQLSEFERESGNKLVDADDSAFQMDRCVSRLYEMRTKEYLEIPHEPQEVDLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5Q3</accession>
    <name>A0A3S5H5Q3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L19, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L19e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_24360</name>
        <name evidence="6" type="ORF">LdCL_060009200</name>
        <name evidence="7" type="ORF">LdCL_060009400</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5Q3"/>
    <dbReference type="SMR" id="A0A3S5H5Q3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060009200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.0510"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU76073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="245" mass="28072" checksum="5C5C7170515E2057" modified="2019-04-10" version="1">MVSLKLQARLASSILGCGRARVWLDPNEAVEIQNANSRKSVRKLIKDGFIIRKPVKVHSRARWRKMKEAKDMGRHNGVGRREGSREARMPSKELWMRRLRILRRLLRKYRADKKIDRHVYRDLYVRAKGNVFRNKRNLVEHIHKIKNEKKKERQLAEQLAAKHLRDEQNRNKARKQELRKREKERERARRDDAAAAAQKKKADAAKKSAAPAAKSAAPAAKSAAPAAKVAAPATKGAAPVKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5T3</accession>
    <accession>E9B8V5</accession>
    <name>A0A3S5H5T3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_060950</name>
        <name evidence="2" type="ORF">LdCL_060014600</name>
        <name evidence="3" type="ORF">LDHU3_06.1090</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858401.1">
        <property type="nucleotide sequence ID" value="XM_003858353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5T3"/>
    <dbReference type="SMR" id="A0A3S5H5T3"/>
    <dbReference type="GeneID" id="13391755"/>
    <dbReference type="KEGG" id="ldo:LDBPK_060950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_060950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1090"/>
    <dbReference type="OMA" id="IPCQCGW"/>
    <dbReference type="OrthoDB" id="277391at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="449" mass="48861" checksum="0C7C53074D896972" modified="2019-04-10" version="1">MTQKLLLAEGLDLLRQCEQREYDVDRTKLRISSSSRYRSELGRLLQSYDTVYHQYVRGIQILNYVRHTALADKNPQNAQYSKNLSEFCAAKITAYMTRCSNIIRKTDSILVPIEQIDLITKEGYTPEDTVYLQDGITYPLSRKEKIIAKEFTLTAGTYVLTLKNRDDYTLAAPEVDVTLVVLPQRGSGLEPSRVEMKLPCQCGWRKVVGVVDVATVQLEIRYSGIRDAHIDVLFQKWCAIEDIGRSGGAASGPGPALSPSTFDSGDCNSVCKPPPNRGGNGGAAGGVSHHSCTPTNVSASDAGAPAHQQPQQWVNSLPQLPDDELATLANYNVPSASLPRVSDRPANDSEAASSAAPSSAEDPWTTLANLNVPYAPTTRNAPSAASVMRVPEPVEVNPAGMTCRQRLDKIHQLMDAWPSIGVVACALPAEPQSFMQGVHALPFPRELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5U9</accession>
    <name>A0A3S5H5U9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cysteine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_060018000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5U9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_061280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1430"/>
    <dbReference type="OrthoDB" id="271433at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF61">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU76159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31796" checksum="2D5817B6ECDE091D" modified="2019-04-10" version="1">MKSPGRCVRFARTPLTTCRPRMKRLIKSLQHFSMTSSEHVESFSKMTLRDFGFYVSDADAMRYVADEAYPIAERAFQLENALHQCRLSASTAQVSPMAWKSSSSDTLGCSTLYQDEAVTLCWFVLPPGKALPLHDHPGMTVWQRAMHGRLHLCSITREADSQTGTGASTAPINGTVVFDGELDGVGDAIPASDVLGFTPADGDGGGMLHEIRNIDATQPALFVDIISPPYNQAPSNIVCGYYTAEPLDATATLLPALAADCGVRHQLKAGDKVRLHPRINYSGPAMNAFLHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6W0</accession>
    <accession>E9BCI5</accession>
    <name>A0A3S5H6W0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ERAD-associated E3 ubiquitin-protein ligase HRD1, putative</fullName>
            <ecNumber evidence="14">6.3.2.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="16">Ring finger domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC21_1275</name>
        <name evidence="15" type="ORF">LDBPK_151460</name>
        <name evidence="14" type="ORF">LdCL_150019900</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="14"/>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859669.1">
        <property type="nucleotide sequence ID" value="XM_003859621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6W0"/>
    <dbReference type="SMR" id="A0A3S5H6W0"/>
    <dbReference type="GeneID" id="13393050"/>
    <dbReference type="KEGG" id="ldo:LDBPK_151460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_151460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.1780"/>
    <dbReference type="OMA" id="ANLTMFT"/>
    <dbReference type="OrthoDB" id="263722at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000703">
        <property type="entry name" value="ERAD-associated E3 ubiquitin-protein ligase HRD1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP47673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="478" mass="52752" checksum="5C1D9F81823DB3DB" modified="2019-04-10" version="1">MVGRTSVVAYVVSSFLACSLFLADYANTYREFYPAMVALANSSSFRLLIVNTAIAFTVVLWMVLQWCFFGQLNASEETALLTSFTLYTVECVVVPLYMDQPIISAASFFFLFTLAWRVLHKLASERVTTLSTVQMTWISATRMPAYLCFAIICDVGLLTWMIKTRPELNEEKASMHYSMILIYMLLLSSSLRSTVHFASLFVLRGQHTLLPFVADAVTSIAESLLFVSVYAYIFYKAALPLLLLRGFVGHVLRIFEKTSGLAEFLVLARRVRNSMPDATAEDLARDVRCTICYEDMVPGGGTKRLPCGHCYHIDCLERWLEGHSTCPYCRANIMQMRGGDGSAVPPTAEAEPAPAGVVEGAAVPEAQEGTPAHQQPTDTSDDMEAEIREAYERYRQQLCPPPPAASSAAATGSHPVATGAGSGSPHRTTPPPSDGMTTPQTADQLKMKAYQEYHKRLREAERELQVALQLAEEAGYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6W4</accession>
    <name>A0A3S5H6W4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_160005600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6W4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0070"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="680"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU77584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="959" mass="103567" checksum="E85BB4264F9B2F0D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7J1</accession>
    <name>A0A3S5H7J1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="3">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_280017000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3 4">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7J1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1560"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000048">
        <property type="entry name" value="Electron-transfer-flavoprotein, alpha polypeptide, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018700489" description="Electron transfer flavoprotein subunit alpha" evidence="5">
        <location>
            <begin position="17"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="268"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="325" mass="33693" checksum="9F0D878821DDCDC5" modified="2019-04-10" version="1">MLRATALSLGKALVIAEMVGGKVSPATLSAITGAAKVGPVAVLVAGASAKAEAQVLAKIKSVASVLVTVGEQYSHGLPEEYAPLIDVAVRANDYTHVFAGTSAFGKNVIPRAAARQSCMPIPEVTEIVDENTFVRQTYAGNAITTIKSSDKIKYCTLRGTAFERAELDGGSAAVAELAATPEVGKAKFLEDQLSTSDKPDLMTAATVISGGRGMKNGDNFKMLEELASPLNAAVGATRAVVDAGYVPNEMQVGQTGKTVAPNFYLACGISGAIQHVAGMKDSKVIAVVNTDEEAPFFQIADYGIVDDLFKVVPALTEKVKAANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7T0</accession>
    <accession>E9BP93</accession>
    <name>A0A3S5H7T0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_34990</name>
        <name evidence="17" type="ORF">CGC21_21215</name>
        <name evidence="16" type="ORF">LDBPK_323430</name>
        <name evidence="14" type="ORF">LdCL_320040200</name>
        <name evidence="15" type="ORF">LDHU3_32.4320</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812652">
        <property type="protein sequence ID" value="CAC5433100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ37071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000003">
        <property type="protein sequence ID" value="TPP47343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863754.1">
        <property type="nucleotide sequence ID" value="XM_003863706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7T0"/>
    <dbReference type="GeneID" id="13391280"/>
    <dbReference type="KEGG" id="ldo:LDBPK_323430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320040200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4320"/>
    <dbReference type="OMA" id="FWEIAQG"/>
    <dbReference type="OrthoDB" id="10263060at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU81893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5433100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ37071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP47343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="425" mass="46936" checksum="D110B1AFD85D9C9A" modified="2019-04-10" version="1">MPGSPVDRKPEASRNGGQKGAAEHLQPPRRPSKTPSEEGAESPLRQSQELSETPTTAATGTSASIVIDPTKDLWQNITRNVKDANVEQTETSLVMVGASGSGKTTLLHRIYTSFQSSSSGSGPKRVKATTALDYSFARRSERNVAPVAHFWEIAQGTQFSQLLDIVLTPENVHAVAAAVVVDASEEGLPVAWETATYWLRRLDQRVSDISQRMKAKGSTTPAKILTRAQKAIGLDHPDLKRMRLSGIPTVLVVNKIDAFRGDMQQLKLLCRSMRYLAHLYGAHVVFTSEQESVRWRALMNFTLFQAPFDPKYLQTDPERSAVLLTVDRDSFLDIGDPDVSRLGGSVSTGDAELDRWKAPFDEAFPPKKLNEEDKVVDDPFIRRLYDTAEGGFGDPVIDALRKQKDEELEQYRKKSSNAANASKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7T8</accession>
    <name>A0A3S5H7T8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heat shock protein 83-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_330009100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7T8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0550"/>
    <dbReference type="OrthoDB" id="276124at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU82004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="700" mass="80467" checksum="5A587F8F7389B64C" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNT5</accession>
    <accession>E9B828</accession>
    <name>A0A3S7WNT5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_2755</name>
        <name evidence="3" type="ORF">LDBPK_040630</name>
        <name evidence="2" type="ORF">LdCL_040011900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000037">
        <property type="protein sequence ID" value="TPP51483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858125.1">
        <property type="nucleotide sequence ID" value="XM_003858077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNT5"/>
    <dbReference type="GeneID" id="13390736"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0850"/>
    <dbReference type="OMA" id="EFMSIIW"/>
    <dbReference type="OrthoDB" id="274904at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="200" mass="23355" checksum="B5C5B55CE8F2E9D6" modified="2019-05-08" version="1">MTMNFGNMTLGGAMATFGGQSNPMCNYTSPLAKKFVYKEVGKVYYPLRRHVFRTKVRTAAEIRFNEIVKRYMKEKMAFKRGCYAATITNTVELDHMGSIIPKDEYEVKRLTSYMTSKKMSNDYKKHMQELWTRVLFVCESTNLVGVTENAMHQNSRPGTDEEFMSIIWYSSFVTTLMAFVVTLCIWWYRYGQAPQYAEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNY4</accession>
    <accession>E9B897</accession>
    <name>A0A3S7WNY4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LDBPK_050070</name>
        <name evidence="14" type="ORF">LdCL_050005600</name>
        <name evidence="15" type="ORF">LDHU3_05.0100</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
            <location evidence="2 13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812625">
        <property type="protein sequence ID" value="CAC5427264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858194.1">
        <property type="nucleotide sequence ID" value="XM_003858146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNY4"/>
    <dbReference type="SMR" id="A0A3S7WNY4"/>
    <dbReference type="GeneID" id="13391346"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0100"/>
    <dbReference type="OMA" id="HAMDTEI"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF90">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU75912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5427264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10661" checksum="3BF030D86DA09C4F" modified="2019-05-08" version="1">MPLKYLEMSYNADMPKDMIKEAQNLIIEAFETESLENAVATHIKREFVKRYKGVWHCVVGKNFGSFVTHEMKGYIYITWGQISILLWKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPN3</accession>
    <name>A0A3S7WPN3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_060017600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPN3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060017600"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9453" checksum="346090AEBBF3E62C" modified="2019-05-08" version="1">MSNRGGQARASPHRSPSRRKEPSLAHQSQQPYPADGRLGPIESACKTPTRKLEEDHCSGAAARSAYKLNKQLFRKLPDLERRGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQW5</accession>
    <accession>E9BA34</accession>
    <name>A0A3S7WQW5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial trigger factor protein (TF) C-terminus family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Bacterial trigger factor protein (TF) C-terminus, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Bacterial_trigger_factor_protein_(TF)_C-inus_puta tive/Pfam:PF05698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_7795</name>
        <name evidence="5" type="ORF">CGC21_36650</name>
        <name evidence="4" type="ORF">LDBPK_091490</name>
        <name evidence="2" type="ORF">LdCL_090021300</name>
        <name evidence="3" type="ORF">LDHU3_09.1750</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812629">
        <property type="protein sequence ID" value="CAC5427938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000053">
        <property type="protein sequence ID" value="TPP42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858827.1">
        <property type="nucleotide sequence ID" value="XM_003858779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQW5"/>
    <dbReference type="SMR" id="A0A3S7WQW5"/>
    <dbReference type="GeneID" id="13392169"/>
    <dbReference type="KEGG" id="ldo:LDBPK_091490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090021300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1750"/>
    <dbReference type="OMA" id="AMAKEHK"/>
    <dbReference type="OrthoDB" id="273179at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="139" mass="16205" checksum="D87C083FD0DCD081" modified="2019-05-08" version="1">MPVDYSKKLDALRELYERVQQKDANIPEDVYAAAGVKNKARLKDIEKEISTTKKKVSQEVKKVTNEEIEKEYEALAKEHNMTVEEFKETVMGKGRQPALGSEFSERHAAQRRERAEQRDLKETRRQVERGDFDMAVDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQW6</accession>
    <name>A0A3S7WQW6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_090021800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQW6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_091540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090021800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.1810"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16319" checksum="8DA1CCAE1BB89F09" modified="2019-05-08" version="1">MIRRTWCLCRCLSVDQVAKIVKAKQSCSDAVRNIQLIDVRSTAEVAATGMIPSAINVPLPVLRDVLSQDGILEDDEFEFFFGGARPVQGVTQMVLYCAHGVRSAIACEIAEELGFENVGNFSGSWAQWYHAYGTPSTSAAAPESLHTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSF2</accession>
    <name>A0A3S7WSF2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_130010900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSF2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130010900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0740"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="627"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="704" mass="75915" checksum="D0E388ECE5298AF6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WST4</accession>
    <accession>E9BBR6</accession>
    <name>A0A3S7WST4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_4565</name>
        <name evidence="7" type="ORF">LDBPK_140310</name>
        <name evidence="6" type="ORF">LdCL_140008100</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859403.1">
        <property type="nucleotide sequence ID" value="XM_003859355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WST4"/>
    <dbReference type="GeneID" id="13391095"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140008100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0400"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000058">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP46214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="285" mass="32191" checksum="2495765A7D055E2D" modified="2019-05-08" version="1">MSHRYDSRTTTFSPEGRLYQVEYAVEAIQQAGTVIGVCTKDGVVLAGEKMVPHPLFDSENMQDKNTSGEKMYKIAEHIGCSVAGVTSDAYALLNYARLSALRHQYTFQEPMAIEDLCRILCDEKQLYTQYGGVRPYGVSFLLVGWDRYYGYQLYSTEPSGDYSAWSAYAIGQNDQVAHSLLKKDWHENMTLEDGMLLALRVLGKTMDTAKIDLARVEVAVMRKVPASNVDQLLDPFKHHPKTTPQFQILALSELKPHAERADQAREAEEQAEAERQRQQEQALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT67</accession>
    <accession>E9BC15</accession>
    <name>A0A3S7WT67_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_5070</name>
        <name evidence="2" type="ORF">LDBPK_141330</name>
        <name evidence="1" type="ORF">LdCL_140019200</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859500.1">
        <property type="nucleotide sequence ID" value="XM_003859452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT67"/>
    <dbReference type="GeneID" id="13391131"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140019200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1670"/>
    <dbReference type="OMA" id="VQQQYCT"/>
    <dbReference type="OrthoDB" id="260148at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP46315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="205" mass="22088" checksum="ACE9479C8271EFCA" modified="2019-05-08" version="1">MTSCERNSSRRPAPLALGVVVSVALVLLGVCGVPAQAATVTDLKNAIKNELSRIDIGMTDFYSSLSVSPTVQQQYCTTAITSRAAGLSLTMESLSTPYGVLATEYGFLIYKDTFVFGPSIKLIGASAWPNGTLTTDIQSGKNILVPYLTNTVVFVTGIIENGDGKQNILPMMRSMMVDSYLCAYMHMNVADLYRNTFRAAFAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTR5</accession>
    <accession>E9BCK8</accession>
    <name>A0A3S7WTR5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginine N-methyltransferase, type I</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L11 methyltransferase (PrmA) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_25335</name>
        <name evidence="7" type="ORF">LDBPK_160040</name>
        <name evidence="6" type="ORF">LdCL_160005300</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000028">
        <property type="protein sequence ID" value="TPP51235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859692.1">
        <property type="nucleotide sequence ID" value="XM_003859644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTR5"/>
    <dbReference type="GeneID" id="13393060"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0040"/>
    <dbReference type="OMA" id="CIHVDYT"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000030">
        <property type="entry name" value="Arginine N-methyltransferase, type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000607">
        <property type="entry name" value="Arginine N-methyltransferase, type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF102">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="182"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="365" mass="40515" checksum="00EB202926962D89" modified="2019-05-08" version="1">MQHQEDYASNASKDDQYFESYADLSVHKVMLRDRPRMDFYKALLTDRSVIEGKVVVDVGSGSGILSCWAAQSGAAHVFSLEASSIAKLQQRVFADNGLSGRVTVIASTVEKLVAAGVEAFLNEHPCVRLHGGVALVVSEWMGFYLFHECMLPSVLRARDFFHDVNAALQSSLTVCMLPSHGRLLVAPITLKPYYAETFAAFWDSVDGVSLHALGKLDFEEHIDATSPLVDVMPQRSLLHDGVVFWEGCFDTLAVGELANIVAARTFDFSTSVTGASARASLDETGRFTVEGFTLWFQVSYGDAILDTSPLAPPTHWKQTTVLLPREFRDEKTVSFHRLNEHLELTLRLTAEDLAQRCYKIEFELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUZ0</accession>
    <name>A0A3S7WUZ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PA26 p53-induced protein (Sestrin), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_180011700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0860"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU77994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1308" mass="136724" checksum="923902C0663B0FDC" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVU3</accession>
    <name>A0A3S7WVU3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_200008550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVU3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200008550"/>
    <dbReference type="OrthoDB" id="10464269at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13713" checksum="979A968257376C24" modified="2019-05-08" version="1">MPATPLSFHTSDRGHLRVLTGSSTHGASGAQIDAALRMSVVIPSMAWRQSEPRQCRRVRHPWDGQCASLTRTYLTRPSHCPAGGVVGSLGHPDGGTAWRPAQWERLCGDLRGGDGGRSLSPRRCSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVZ5</accession>
    <name>A0A3S7WVZ5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_200013500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVZ5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1090"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003509">
        <property type="entry name" value="Putative ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="477"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="768" mass="82134" checksum="3A17DDECF5441234" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WW17</accession>
    <name>A0A3S7WW17_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200014600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WW17"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.1220"/>
    <dbReference type="OrthoDB" id="263620at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="692" mass="75945" checksum="85474C808C1146A6" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWQ0</accession>
    <accession>E9BFE2</accession>
    <name>A0A3S7WWQ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_22165</name>
        <name evidence="4" type="ORF">CGC21_34415</name>
        <name evidence="3" type="ORF">LDBPK_211560</name>
        <name evidence="1" type="ORF">LdCL_210021100</name>
        <name evidence="2" type="ORF">LDHU3_21.1850</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860673.1">
        <property type="nucleotide sequence ID" value="XM_003860625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWQ0"/>
    <dbReference type="GeneID" id="13386454"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1850"/>
    <dbReference type="OMA" id="YGQWEVE"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5429891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP49375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="358" mass="38988" checksum="7C3EDC7F325374DF" modified="2019-05-08" version="1">MRCVRALLHGKLSYPVGTGRLALGTELLPLFPSNDIFYDPPKLRYRLDQDGYLYFKNTVPRDVVNAALDDLATQMRECGLTLDEDRARQAELHGFAMGVPYPSTSGGELPPPNIHHTDTIRNAVSGTSVMATVRQVFGGAVQATALQTLHLGAPGESFGFRMPSVFLNRGTKLALVAIVPLHDTPLHMGTPLLVRSSNSHDTYAQLRKTYGQWEVEGDSIRGDGCYTENPAELSPFGKLPGTDDTTGASIIVDVNPFVSSALEAGDVLLTTVYTMQSFLTNQTNCWRLMAEAVWCMDGDDVGLDPRYMGSAAPGLAAWTERRDDPTVYPKSLMEAKKEWGLVPDLAAVTMDESKTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXI7</accession>
    <name>A0A3S7WXI7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_220021900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXI7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_221460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.2100"/>
    <dbReference type="OrthoDB" id="272371at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="730" mass="77050" checksum="AF524EFCEC50243C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXN0</accession>
    <name>A0A3S7WXN0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_230015400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXN0"/>
    <dbReference type="SMR" id="A0A3S7WXN0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230015400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1190"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="119"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="573"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="695" mass="77197" checksum="B7091D06A2BA4C9F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXY1</accession>
    <name>A0A3S7WXY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230025400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXY1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231830.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2410"/>
    <dbReference type="OrthoDB" id="10356415at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22234" checksum="601B5D3BB89F7D0D" modified="2019-05-08" version="1">MHFGDDDVKKLSPTNQAMRNIDHMEPEMHLASGLRCEEVSVIHSPVPRRAVWMMRVFACISMLLSAALFVLWVIFAFAFGLLLTAAHGTALGAFVVTAFVISIFGAVAYLLTTLFVAVLLQCSLCYRCRSSNATRLSCYEAAMCALILLFSCALSCFTGFLLADSRSDQNMKMLTAMCVLTTFCTVSFGAFSVLLVMHGVPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0C8</accession>
    <accession>E9BIV8</accession>
    <name>A0A3S7X0C8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_1445</name>
        <name evidence="5" type="ORF">CGC20_33235</name>
        <name evidence="3" type="ORF">LDBPK_270230</name>
        <name evidence="1" type="ORF">LdCL_270007200</name>
        <name evidence="2" type="ORF">LDHU3_27.0290</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000019">
        <property type="protein sequence ID" value="TPP43935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861881.1">
        <property type="nucleotide sequence ID" value="XM_003861833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0C8"/>
    <dbReference type="SMR" id="A0A3S7X0C8"/>
    <dbReference type="GeneID" id="13389142"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0290"/>
    <dbReference type="OMA" id="VVPKPRW"/>
    <dbReference type="OrthoDB" id="274902at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP46163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="187" mass="21565" checksum="F92BA8937A538275" modified="2019-05-08" version="1">MSSGALGRGSFHSVVAGANPRRIPTYYNSAYELIQLHRAHREVTRNFLVRDKVFDNKFPGCSLANGLFKMVPNKRGNFHTRELTESIRHRTIWAQRIQQQRTINAAILDDATKVLSPAQMEDRFSYRTPDAAAYFSPQEYTAANNWPNYWQHPTEKHVVPRPRWRREPELGGITRVRDAVATPIADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X168</accession>
    <accession>E9BK55</accession>
    <name>A0A3S7X168_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CGC20_13995</name>
        <name evidence="31" type="ORF">CGC21_21625</name>
        <name evidence="29" type="ORF">LDBPK_280150</name>
        <name evidence="27" type="ORF">LdCL_280006400</name>
        <name evidence="28" type="ORF">LDHU3_28.0180</name>
    </gene>
    <organism evidence="27 33">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="29 32" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 32">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="27 33" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 33">LdCL</strain>
        </source>
    </reference>
    <reference evidence="35" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="30" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">FDAARGOS_360</strain>
            <strain evidence="31">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="34" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="28" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862116.1">
        <property type="nucleotide sequence ID" value="XM_003862068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X168"/>
    <dbReference type="GeneID" id="13386852"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0180"/>
    <dbReference type="OMA" id="CVLYYSA"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="AYU80168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAC5431397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CBZ35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="TPP40614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="TPP54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="528" mass="57529" checksum="A1565EC83155F236" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1H2</accession>
    <accession>E9BJI9</accession>
    <name>A0A3S7X1H2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-grasp domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ATP-grasp domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_22075</name>
        <name evidence="8" type="ORF">LDBPK_281180</name>
        <name evidence="7" type="ORF">LdCL_280016400</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862217.1">
        <property type="nucleotide sequence ID" value="XM_003862169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1H2"/>
    <dbReference type="GeneID" id="13386953"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1470"/>
    <dbReference type="OMA" id="YTLKCLD"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="247"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP54256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="785" mass="86485" checksum="A214A939A6739984" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X202</accession>
    <name>A0A3S7X202_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280035400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X202"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280035400"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25174" checksum="DE128335F07F38BC" modified="2019-05-08" version="1">MSAAFSRRFVASSPGTPLAPAATSTSSPTNAKAMRTPPNHQMTTPSVDFVADRVDASVPRQLERRTKRQEGLARAKDRTIVQPEGRARELGDAPAVAAAASENTSSQAATVTVYLDDLEQLRRDAHALKVLVQHHRAAQAAHGLFTPFIPPTPTTTTAAAPSAVSDISTTLRFVREALSYVLSHPSCAAGPSSTMRVLQPTTVAEGYRSSGILSDAAKELADLMRRYAASTCHDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2L7</accession>
    <name>A0A3S7X2L7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_290022900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2L7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290022900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2500"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019471218" description="Transmembrane 9 superfamily member" evidence="8">
        <location>
            <begin position="46"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="681" mass="76498" checksum="877AB665FC9AA99A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3B5</accession>
    <name>A0A3S7X3B5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferric reductase transmembrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_300021600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3B5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2140"/>
    <dbReference type="OrthoDB" id="260856at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000202">
        <property type="entry name" value="Putative ferric reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="580"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="928"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118451" checksum="2CD17113361C3CD0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X402</accession>
    <name>A0A3S7X402_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_310006000</name>
        <name evidence="2" type="ORF">LDHU3_31.0140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X402"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0140"/>
    <dbReference type="OrthoDB" id="258045at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9397" checksum="FDAE45725E3C9721" modified="2019-05-08" version="1">MLRLAIARRQLQRQLYAGGIAYGAAFAARNEHDATAYQRATALYSPASTSIRRRKWHVERQNAYAAKRKLMGAMARNELGMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X466</accession>
    <name>A0A3S7X466_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310010500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X466"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0730"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003652">
        <property type="entry name" value="Uncharacterized protein LmxM_30_0480b_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019114457" evidence="2">
        <location>
            <begin position="24"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="384" mass="41733" checksum="40B3ACA06CACA81C" modified="2019-05-08" version="1">MLRCTALVQLRVLCLTMLPDGGALTPALRKLGYTPYTLRSTYQQGHASTHPIEWSQLLDGKTNALPAKVLADYDAVVGPPGAMVYDVLLRQAPSYTKVILVEETEKDKWAEKYDTYLERLQISTKRASKNRITQAFQNMIAKMVVGGDASGAPAAASAGPRSSLSTRHSRSLMISSSGDLRRSFAAEAAELKRGFCGSKAPSPTSASDPSEDSRGTAKARHAKKESNASDGELQHPRAVALQLYEESVRVSIPPSALLVYRYGDGWEPLCSFLDKPVPSIPFPEYEDGLRVLGNLQERIDRAHTLQYVVGGICVLCVLMTVLPRCEGIVEFVKSLYTDYQVAFGADSAACARTTAGGDCSKTEVETFETAWQKRGGSVTRTAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4H5</accession>
    <accession>E9BMT6</accession>
    <name>A0A3S7X4H5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_11440</name>
        <name evidence="2" type="ORF">LDBPK_311620</name>
        <name evidence="1" type="ORF">LdCL_310023300</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863253.1">
        <property type="nucleotide sequence ID" value="XM_003863205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4H5"/>
    <dbReference type="GeneID" id="13389427"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311620.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2830"/>
    <dbReference type="OMA" id="LGIYNQR"/>
    <dbReference type="OrthoDB" id="275968at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ36564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="186" mass="21832" checksum="FF6E0F1AA67CA411" modified="2019-05-08" version="1">MLQYTSSARQALRATALVLSFFPLGYTCGPKNKQVFFPPNNLDGRTTHQMRKLQGSTDKHPGLVPRDKLKLHCEFCRFHWIQDTLVVRCAAHPKEHNQREIWLEPTWTWGKQQPYQYYKYMPVNINPRTGMPLAREDAKSMNNERRSQGLPTKTRLLEQERRGISRAITGLGIYNQRWQTRFPFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X679</accession>
    <name>A0A3S7X679_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHQ1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_320045600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X679"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320045600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.5090"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000080">
        <property type="entry name" value="Protein SHQ1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHQ1-like CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Shq1 C-terminal" evidence="2">
        <location>
            <begin position="357"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="577" mass="63390" checksum="7843432FE5D3AFAB" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X722</accession>
    <name>A0A3S7X722_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330031400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X722"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330031400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3490"/>
    <dbReference type="OrthoDB" id="277340at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="525" mass="57047" checksum="922811E3AE0BA803" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8R1</accession>
    <accession>E9BRK5</accession>
    <name>A0A3S7X8R1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of DNA damage checkpoint protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LDBPK_344070</name>
        <name evidence="15" type="ORF">LdCL_340050100</name>
        <name evidence="16" type="ORF">LDHU3_34.6380</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5434004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864566.1">
        <property type="nucleotide sequence ID" value="XM_003864518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8R1"/>
    <dbReference type="SMR" id="A0A3S7X8R1"/>
    <dbReference type="GeneID" id="13387445"/>
    <dbReference type="KEGG" id="ldo:LDBPK_344070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_344070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340050100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.6380"/>
    <dbReference type="OMA" id="YICNDQA"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU82774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5434004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ37884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="410" mass="43938" checksum="7B8426B98C0581B7" modified="2019-05-08" version="1">MSTTAYALVANERQYPLQVGKNVVGRSSVPVEGVSFINLESPLAAISRMQAFVDIGANGDAWISDCNSTNGTFLSIRPGPGIRLEANRYYQLSPGCRIVFGDVVCTFETLSEALQAPEHPEHPLTSLSLPTRKTESLGVIDAFTDSAAKTTPLRHPSKQANAHRSNVPYLDESGSLSREPAALRETVSTTKKAPRRERREPTAPSPPLKRTKVESAAPSSSLKVETAATAKATTAARAHAARPHVCLTGMDSDERAAVTKRVRELKGRVVDDITKANLLVVAAPPVRTPKFIVAVARGIPVVSVDYICNRRAALDDARHHIVGLKTDQHTYTAAELKKVIYRKDASPLLQGVSFNIAALSTKTKSVAAEIISSSGGEVVSTKKGGGTALTDEQLDKLYDSILRGKVSDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA31</accession>
    <name>A0A3S7XA31_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zeta toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_350057000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA31"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350057000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6830"/>
    <dbReference type="OrthoDB" id="271259at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF2">
        <property type="entry name" value="2-PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33546" checksum="1D015AAE09335CAF" modified="2019-05-08" version="1">MSSKYDVIKVKVHLSDVHYYVLSRFLLSRMLMFCRVPEDTAVRISLDVKKHFVNTERTSITQAELEDYIRCSMIAAGFAQEHAQLFSVVTQFHAERIPLILFIAGPERCGKTTLAHLLAARINCSTVINAEVLRDISASIDDSLPSFAVSETSSPDSTPSMLRGVEVSAAVAAEVDKAVREGQAIIVEGENLSFAGFHRFLEPSFQFSTGAVILGLVMDTCGSEAETDASHAYVKALPNLQPVFSTERLTVFAADMVDLAKGVSGIPTVYVARCTTVADNVCLSVFLHDIVVKRIIAELKRRGRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XA97</accession>
    <name>A0A3S7XA97_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAP domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360005500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XA97"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0120"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="322" mass="34712" checksum="562100F5F5B30A54" modified="2019-05-08" version="1">MDPVKRRLVYVADENEVLLSDLSGTPPTRQSRHTQLLVPLSPPTSSQQSPHSVSPPPRPVDATAEAAPVATADKALLVSYDGFLLTGGSGRFSTPRDAAQAADIRDALKTCRSFLKGFLNAARPESESTESCSSGASSSTYMEEEDSDLEETSSDDSPVSRPRATKAARARPPHSHIHNPTQMTVAELKELLRNRGLSIAGNKACLVKRVQKLRAHESERALETGPLRLGAGQRTLQGSLRHETKLNSGVSVLSPPLSPLPSQRKSPNCHTTDEKNNSIWGALVHAGSRLFRGGARASWGFHTRPPEDADDAPLSTRRRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAE3</accession>
    <name>A0A3S7XAE3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial ATP synthase epsilon chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_360011700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAE3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0840"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="266" mass="30315" checksum="92EDEF2D00D3A6AA" modified="2019-05-08" version="1">MMCDLRPLILSFSVSSPVCLLAAIVWPVPLSRVFVHAGHNVGVRVYHVPFIVLFSLKLPRLCCGCTFNPPPAESDTLPAIPLSTSPWTYANKWQRNTKTRLPCCPLPYQEQWWSLSLRVSSRLSPPMYLPLSTAPDTVLSPPTSPRPKRTEAVASIRACRSTHSYRAIFRHRFLWFHLRRLSVLQYRGSLSPMMLRRSLIALNWRDQGISYVKYLNVTTEALHMATKDKARAKYSRFSAPNYVAMKNDSTGAMEEVKKVPAFTKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBU4</accession>
    <name>A0A3S7XBU4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360065800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBU4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360065800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7740"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14594" checksum="1CCD2888362CCEB6" modified="2019-05-08" version="1">MAAAARVRFAAKQSVRTTPVKGADTGVMDPLTVELYTLSIVKDAPRELLLDAERRQWQYRTSSAEAAKEEDEEEDSVPADEADIISEAAERRVDDDKSHSQLYTVELEGAGLVSGSTAIEAALKTRSIVPLASGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBX7</accession>
    <name>A0A3S7XBX7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_360067900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360067900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7980"/>
    <dbReference type="OrthoDB" id="278628at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="CDD" id="cd23515">
        <property type="entry name" value="MPSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019058455" evidence="2">
        <location>
            <begin position="16"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1865" mass="204439" checksum="57F6CB632BBC8BA7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC66</accession>
    <name>A0A3S7XC66_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homocysteine S-methyltransferase, putative</fullName>
            <ecNumber evidence="9">2.1.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_360073400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.10" evidence="9"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC66"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360073400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8710"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000002">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019319391" evidence="7">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU84018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36562" checksum="10D2D8CB7B55A4DC" modified="2019-05-08" version="1">MENHHFLCWGLLANWKVGGMEAYLADPNQVVMLDGGLATELETRGCDLLDPLWSGKVLLESPQRIRDVALAYLRAGARCIITASYQITPQSLMEHRGLTEDAAVAAIEESVRIAQSVRERHLKEKPQAAPVFVAGSVGPYGAYLADGSEYRGDYVRSAEEFKEFHRLRIAALLRAGADVLAIETQPSAAEVRAIVALLQEEHPNCRAWVSFTTSRISPVEAISDGTKWADIISFLEKAPQVVAVGVNCIPMAEASAVLAHLHTLTTMPLVVYTNSGESYDTVTRTWHPIPMRDGTTLSLAALAREWASHGARLVGGCCRTGPSDIAGAAAALDSAGFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>E9B818</accession>
    <accession>A0A3S5H5B1</accession>
    <name>E9B818_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_040530</name>
        <name evidence="8" type="ORF">LdCL_040010800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799591">
        <property type="protein sequence ID" value="CBZ31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858115.1">
        <property type="nucleotide sequence ID" value="XM_003858067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B818"/>
    <dbReference type="GeneID" id="13390726"/>
    <dbReference type="KEGG" id="ldo:LDBPK_040530"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040010800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0710"/>
    <dbReference type="OMA" id="VPCGDIF"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="PhylomeDB" id="E9B818"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU75832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="592" mass="63861" checksum="763AFD608EE26375" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9B8H7</accession>
    <accession>A0A3S7WP93</accession>
    <name>E9B8H7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_050870</name>
        <name evidence="2" type="ORF">LdCL_050013800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799592">
        <property type="protein sequence ID" value="CBZ31550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858274.1">
        <property type="nucleotide sequence ID" value="XM_003858226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13391324"/>
    <dbReference type="KEGG" id="ldo:LDBPK_050870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0960"/>
    <dbReference type="OMA" id="CLVRVRW"/>
    <dbReference type="OrthoDB" id="273921at2759"/>
    <dbReference type="PhylomeDB" id="E9B8H7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1706"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1792"/>
            <end position="1802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ31550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1938" mass="204714" checksum="1CD4CD4CC88B50D6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BBR5</accession>
    <accession>A0A3Q8IBX5</accession>
    <name>E9BBR5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_140300</name>
        <name evidence="2" type="ORF">LdCL_140008000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859402.1">
        <property type="nucleotide sequence ID" value="XM_003859354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BBR5"/>
    <dbReference type="GeneID" id="13391094"/>
    <dbReference type="KEGG" id="ldo:LDBPK_140300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_140300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0390"/>
    <dbReference type="OMA" id="CFMYDAM"/>
    <dbReference type="OrthoDB" id="278326at2759"/>
    <dbReference type="PhylomeDB" id="E9BBR5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26345" checksum="6547E567A623011E" modified="2011-04-05" version="1">MGSWDSAYEDDAMDTRKLYCKALVHASGGSRLARDWIAGCAALTSPDPSLIYTALQHAATEADVEELREHILGRLLGQESPRRGGRSGGSRDNEVRTNFGMCAESEKEVVVPGTGNVAAERAVAPNCAGQPSIHERDGEDGASEAASPPITSEGIRDAEHYLLQRSREVRCFMYDAMTASLFHSNNDLRTVEAARRHTFWIGLAQFGLSFDELTALWRLVEAELLLKKEKIKVLGQPWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9BEE7</accession>
    <accession>A0A3S7WVN3</accession>
    <name>E9BEE7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline/Carnitine o-acyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_191570</name>
        <name evidence="7" type="ORF">LdCL_190021500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860330.1">
        <property type="nucleotide sequence ID" value="XM_003860282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BEE7"/>
    <dbReference type="GeneID" id="13386154"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190021500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1910"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="PhylomeDB" id="E9BEE7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000017">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="195"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="865" mass="97124" checksum="269521020DD246C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BFF9</accession>
    <accession>A0A3S7WWS0</accession>
    <name>E9BFF9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_211730</name>
        <name evidence="2" type="ORF">LdCL_210023100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860690.1">
        <property type="nucleotide sequence ID" value="XM_003860642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BFF9"/>
    <dbReference type="GeneID" id="13386532"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210023100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2040"/>
    <dbReference type="OMA" id="LWAHEAP"/>
    <dbReference type="OrthoDB" id="267675at2759"/>
    <dbReference type="PhylomeDB" id="E9BFF9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="666" mass="69142" checksum="4FF570F5280000DF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGC3</accession>
    <accession>A0A3Q8ICJ7</accession>
    <name>E9BGC3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_231040</name>
        <name evidence="2" type="ORF">LdCL_230017200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861003.1">
        <property type="nucleotide sequence ID" value="XM_003860955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGC3"/>
    <dbReference type="GeneID" id="13390202"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1400"/>
    <dbReference type="OMA" id="TYSMPID"/>
    <dbReference type="OrthoDB" id="272606at2759"/>
    <dbReference type="PhylomeDB" id="E9BGC3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="776" mass="86001" checksum="4DD7354E744912E0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIF2</accession>
    <accession>A0A3S7WZV2</accession>
    <name>E9BIF2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MORN repeat/FYVE zinc finger containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_261400</name>
        <name evidence="8" type="ORF">LdCL_260019600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861727.1">
        <property type="nucleotide sequence ID" value="XM_003861679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13388973"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1710"/>
    <dbReference type="OMA" id="CAGERHG"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="PhylomeDB" id="E9BIF2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="995"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1446"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1782"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2035"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2107"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2213"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2290"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1364"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1789"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2038"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2220"/>
            <end position="2229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2290"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2313"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2348"/>
            <end position="2363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2421" mass="257004" checksum="DF79123C153248E8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>E9BIL4</accession>
    <accession>A0A3Q8IDS4</accession>
    <name>E9BIL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_262030</name>
        <name evidence="2" type="ORF">LdCL_260025900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861788.1">
        <property type="nucleotide sequence ID" value="XM_003861740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BIL4"/>
    <dbReference type="GeneID" id="13389035"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.2660"/>
    <dbReference type="OMA" id="NLPMVFD"/>
    <dbReference type="OrthoDB" id="272429at2759"/>
    <dbReference type="PhylomeDB" id="E9BIL4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="755" mass="79539" checksum="0F84B6C827B2814B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJG8</accession>
    <accession>A0A3S7X110</accession>
    <name>E9BJG8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_272380</name>
        <name evidence="2" type="ORF">LdCL_270032200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862089.1">
        <property type="nucleotide sequence ID" value="XM_003862041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJG8"/>
    <dbReference type="GeneID" id="13386824"/>
    <dbReference type="KEGG" id="ldo:LDBPK_272380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270032200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.3610"/>
    <dbReference type="OMA" id="YVEMCKE"/>
    <dbReference type="OrthoDB" id="751084at2759"/>
    <dbReference type="PhylomeDB" id="E9BJG8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="570" mass="57738" checksum="88BD2A206CE5461A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKL8</accession>
    <accession>A0A3S7X260</accession>
    <name>E9BKL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase complex I subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_290720</name>
        <name evidence="1" type="ORF">LdCL_290011900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862489.1">
        <property type="nucleotide sequence ID" value="XM_003862441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKL8"/>
    <dbReference type="GeneID" id="13387228"/>
    <dbReference type="KEGG" id="ldo:LDBPK_290720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0990"/>
    <dbReference type="OMA" id="TIADEPW"/>
    <dbReference type="OrthoDB" id="270329at2759"/>
    <dbReference type="PhylomeDB" id="E9BKL8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018072">
        <property type="entry name" value="Conotoxin_a-typ_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60014">
        <property type="entry name" value="ALPHA_CONOTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ35796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="278" mass="31354" checksum="6A8828A1BAB26BCF" modified="2011-04-05" version="1">MLLRASASSTLRTRGGSCCSGVCTGLYGFGCLTVQQRFIEYWGSGVTGRTQPYAQGDMIPRVDNMRYPVNKATSAAASLTGNQSCIAYDTSNIFRVEGFSPLEKEHYQSLRGSTRHKVEPLPPHIGKDVMVLLKSMSEEGLLEEYWWTRVVKDFPSLKTPCTAEFKSAWEKFYAEASGVAHDDEAVKAISRPFLQTQMQKNYIAYAMVWRLAERLCEAFDAAPQLTVYERRGGRLAVERVTKLMLDTIADEPWAHQETTSPLHVDISNFRAWHEAGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>E9BKQ0</accession>
    <accession>A0A3Q8IF28</accession>
    <name>E9BKQ0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_291040</name>
        <name evidence="3" type="ORF">LdCL_290014400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862521.1">
        <property type="nucleotide sequence ID" value="XM_003862473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BKQ0"/>
    <dbReference type="GeneID" id="13387259"/>
    <dbReference type="KEGG" id="ldo:LDBPK_291040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290014400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1420"/>
    <dbReference type="OMA" id="MRYMLTD"/>
    <dbReference type="OrthoDB" id="271210at2759"/>
    <dbReference type="PhylomeDB" id="E9BKQ0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62869" checksum="A77BF613C397373F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMH4</accession>
    <accession>A0A3S7X491</accession>
    <name>E9BMH4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_310510</name>
        <name evidence="3" type="ORF">LdCL_310010600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863141.1">
        <property type="nucleotide sequence ID" value="XM_003863093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMH4"/>
    <dbReference type="GeneID" id="13385862"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0740"/>
    <dbReference type="OMA" id="FLQRPYC"/>
    <dbReference type="OrthoDB" id="260642at2759"/>
    <dbReference type="PhylomeDB" id="E9BMH4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="154"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="590"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="822" mass="89037" checksum="E3938C792598DA5F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPL0</accession>
    <accession>A0A3Q8IF25</accession>
    <name>E9BPL0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_332720</name>
        <name evidence="2" type="ORF">LdCL_330034300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864096.1">
        <property type="nucleotide sequence ID" value="XM_003864048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPL0"/>
    <dbReference type="GeneID" id="13392492"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332720"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330034300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3860"/>
    <dbReference type="OMA" id="NECLFWW"/>
    <dbReference type="OrthoDB" id="267814at2759"/>
    <dbReference type="PhylomeDB" id="E9BPL0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="579" mass="59921" checksum="144EE57AEFFB26E4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPX4</accession>
    <accession>A0A3Q8IDL0</accession>
    <name>E9BPX4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_330450</name>
        <name evidence="1" type="ORF">LdCL_330010000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863869.1">
        <property type="nucleotide sequence ID" value="XM_003863821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPX4"/>
    <dbReference type="GeneID" id="13392266"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330010000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0700"/>
    <dbReference type="OMA" id="AWRAQWA"/>
    <dbReference type="OrthoDB" id="272603at2759"/>
    <dbReference type="PhylomeDB" id="E9BPX4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24262" checksum="DACED0BE2B1AAB69" modified="2011-04-05" version="1">MHDRTLSGSGHHRTAVATWSYLLPSLRQNVEQAVPDTLYEKLLTDEVPLTPAESRQLADAHRLLRFELQKRIGLLEDSLADAALPYLLQWPALFQRAWLRLPMDQGSASVTDAKRDAVVPAPPSFVHAPAALPITEWAPTLSPASPSACSNGLIGRGALVPRLAQLTRHVIRCVEEDLGRLEHGSEPREDGAPRSRRQVTLEAAWRAQWASLLSWHAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQE7</accession>
    <accession>A0A3Q8IGP7</accession>
    <name>E9BQE7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_332170</name>
        <name evidence="2" type="ORF">LdCL_330028700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864042.1">
        <property type="nucleotide sequence ID" value="XM_003863994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQE7"/>
    <dbReference type="GeneID" id="13392438"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3150"/>
    <dbReference type="OMA" id="RWILHIL"/>
    <dbReference type="OrthoDB" id="271945at2759"/>
    <dbReference type="PhylomeDB" id="E9BQE7"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44850" checksum="C5AB44B52C8E83A0" modified="2011-04-05" version="1">MTSVSSSATAVAEQQAMPSADTIQQLQEAFSFVRHEREDVRKMAIRGIAAHSKENRDLWLFLASPQYGRSCIDSLLQYLHAGGKPVLGDILTILVNCSADGSCAEMLVQRKVVRKAMRLLDGMERSDQPEPYVRSVQELTLMLLNNLTSSHVTAIDDFLQRDDEDMRGFYLGKLQVYYERFLSAMEAEAAKKAEDEEAAAQAGGNSAKPKPASSLASSHRDLSRWILHILLNLTRTLDGQELLLEDEDWRGTLSSSLSSPNPRHRSLAAQCYRNCGCSPKPLYGLILKSDALVTAVDRLNCKEPIEDIQRSLAEFIASMLESEDGMARLESVNAKRVLSEALGASQAAHAAKAAATAASCVEMAEDDGVPVAATATVTLAPSVIEFLQQSVLPYLEDIVDAYIAPGSDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>E9BR67</accession>
    <accession>A0A3Q8IIP5</accession>
    <name>E9BR67_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_342690</name>
        <name evidence="8" type="ORF">LdCL_340034900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864428.1">
        <property type="nucleotide sequence ID" value="XM_003864380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BR67"/>
    <dbReference type="GeneID" id="13392837"/>
    <dbReference type="KEGG" id="ldo:LDBPK_342690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_342690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340034900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4620"/>
    <dbReference type="OMA" id="DYELQPN"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="PhylomeDB" id="E9BR67"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000021">
        <property type="entry name" value="Ubiquitin-related modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ37746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11054" checksum="94CC1F8BA7BD8D20" modified="2011-04-05" version="1">MQMTHRKIKVVLSGGCELLFDKEVNITLADVVPVGATVAQLIDLLRRGYVKERPELFVDATGANVRPGILVLVNGCDAEVLGGVEHVLEDGDEVEFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>E9BT24</accession>
    <accession>A0A3S7XA73</accession>
    <name>E9BT24_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_355050</name>
        <name evidence="1" type="ORF">LdCL_350059300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865082.1">
        <property type="nucleotide sequence ID" value="XM_003865034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BT24"/>
    <dbReference type="GeneID" id="13387960"/>
    <dbReference type="KEGG" id="ldo:LDBPK_355050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350059300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7120"/>
    <dbReference type="OMA" id="QYVWESC"/>
    <dbReference type="OrthoDB" id="272461at2759"/>
    <dbReference type="PhylomeDB" id="E9BT24"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ38403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27344" checksum="E6AE35D64C36FDFB" modified="2011-04-05" version="1">MRSGRCRLPPAVAARSLLSPFGIGVSKRIALVGSGNSITALLVKENVPAGTPLLLAPDAALLTCQGALDADVDGLVPPPAEMLELLKRDTAQLDHVYLAYYLSLRCFTKTEDWFSGQIHRFKDGGSTSQEDAASSRIWERFAQKYVTAPAPVFLAALQYVWESCFCKPATEADSSSAPLTAALAVAPVVDVAVQSRNAANSALTATTAKALKETYLRGDITGARQALLAKNDASVYWVLTAITDIAVGGEVSVSSESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BTD4</accession>
    <accession>A0A3S7XAG1</accession>
    <name>E9BTD4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KREPA4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_360750</name>
        <name evidence="2" type="ORF">LdCL_360012400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865191.1">
        <property type="nucleotide sequence ID" value="XM_003865143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BTD4"/>
    <dbReference type="GeneID" id="13388077"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.0940"/>
    <dbReference type="OMA" id="MEDVYDG"/>
    <dbReference type="OrthoDB" id="262039at2759"/>
    <dbReference type="PhylomeDB" id="E9BTD4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28736" checksum="11EC21F65E253A02" modified="2011-04-05" version="1">MRHCYRLFTGSRNITTASSSGPTMSLREATRLAKIAGCVDSANGSSSSLLRRCTDPACAQDRKVTSSSASWEEIKRRQHQVFNERHLTAENAIAVTVSCVNMAHLSVYVHAVQCGYPASHAPGPSGEGVPGKRTIATATLTNQSCAVLLLWVSMGSPELLAVRCALSPGAVETCWRAAPAAESSDTTKAGGTSQTAAPSSMLSEKDKLRRIKAWAEELTLHRWVVASGQLRMEDVYDGDLQKVVTVPVLEVARDHFKGSVRALPPGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2D1QVA3</accession>
    <accession>E9BNI4</accession>
    <name>A0A2D1QVA3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin 9, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cyclin CYC9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cyclin, N-terminal domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_19970</name>
        <name evidence="4" type="ORF">LDBPK_320800</name>
        <name evidence="3" type="ORF">LdCL_320013600</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2017" name="PLoS Pathog." volume="13" first="E1006615" last="E1006615">
            <title>Cell cycle stage-specific transcriptional activation of cyclins mediated by HAT2-dependent H4K10 acetylation of promoters in Leishmania donovani.</title>
            <authorList>
                <person name="Chandra U."/>
                <person name="Yadav A."/>
                <person name="Kumar D."/>
                <person name="Saha S."/>
            </authorList>
            <dbReference type="PubMed" id="28938001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1S</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KY445837">
        <property type="protein sequence ID" value="ATP16463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863498.1">
        <property type="nucleotide sequence ID" value="XM_003863450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2D1QVA3"/>
    <dbReference type="SMR" id="A0A2D1QVA3"/>
    <dbReference type="GeneID" id="13390310"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320800.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1000"/>
    <dbReference type="OMA" id="CYWHEFV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000187">
        <property type="entry name" value="Putative cyclin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ATP16463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP43595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="296" mass="32962" checksum="AA7DEA1376D0FECE" modified="2018-01-31" version="1">MSSSPSSPVHSSPASTGFAAPYLPSFTRRYFRLSQSAFVISDYLVRKFRLTESVLLTSLCYWHEFVAAHGLRKANEIVLATTCVFLAAKVEHAHIRLARLVEAAFDLDVNTTAPAELEQWCRAVLDVELVLCDTIRFDFVRIFPLADTLRSVQTLAEAGQLQDAARQEIGTAVRRVFLFSFVTPLCIKVSMQRLCTSILYMIVTAARRELVTAFQSIWSAPEAEFPDEAELEGITAVLMDVFAYLHKKFGVPALDDVNEARYKRCRSQHGNDAGVASSVFSSASADFTPLMKMSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9J3</accession>
    <accession>E9BBI0</accession>
    <name>A0A3Q8I9J3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">EF-hand domain pair family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_33450</name>
        <name evidence="5" type="ORF">LDBPK_131060</name>
        <name evidence="4" type="ORF">LdCL_130015900</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859317.1">
        <property type="nucleotide sequence ID" value="XM_003859269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9J3"/>
    <dbReference type="GeneID" id="13390744"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1290"/>
    <dbReference type="OMA" id="FPQFATM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU77183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="202" mass="21983" checksum="924DB40A3C1EBE40" modified="2019-04-10" version="1">MQKLSETEQKELKEIFDLIDSDQSGVISLQELRKLMAALHLKPTEQELEEVFEETCSLPSITKASAGSPSASSLPLPPSFIAAAAPHDGSVVNNSHSDINASSEATAAAASACMVTFPQFATMMARRVQSEYTAKQLRNAFQLFESPDMPEGFVSTSVLAHALATYGSKKLDKEEIDRLMAAIDPNNTGRVNYYEFVDTVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAG8</accession>
    <name>A0A3Q8IAG8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_160020400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160020400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1830"/>
    <dbReference type="OrthoDB" id="273740at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1468" mass="157288" checksum="9E2EEFEA874F3EA2" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAS5</accession>
    <name>A0A3Q8IAS5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinonprotein alcohol dehydrogenase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200011500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0820"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1520" mass="157654" checksum="9663D644D8000F83" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAY2</accession>
    <name>A0A3Q8IAY2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_100006500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAY2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0230"/>
    <dbReference type="OrthoDB" id="273454at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="372" mass="38074" checksum="6818023203989FBD" modified="2019-04-10" version="1">MSDMNMDMRIHNMKYTSGLESGPFTSEGVLSTNADPAHDYEASATALGAHSTLFHALAAVEEDDDGENSNDVLLRLLNEVRAVESDGDDDEVEVIDKGSDENAAGALALRHGEEPAKPYMPPYTAVPRGGGAIIAGGFTVEGNASYSSAASLPPPPPPPPPPPPPPPAYSTPSMAPRSPYANCYSGIPHLSTTPGSKPPPPSFAEAMATAHGTPASLLGRSVPSQECSPMLANYVPPMPAAPQETVLLRNSNGVFLLQPISKPTPPYTPPAGSTSPPVSPLPRYSLPPAAASTLNTAAANGFLGSSMVQAGARASSITEPLHYAPFGPAGGSPYLSATVPYSHDVGSVRGTPSLGTAPPPYACGAPRGPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB96</accession>
    <accession>E9BDZ5</accession>
    <name>A0A3Q8IB96_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_38965</name>
        <name evidence="4" type="ORF">CGC21_5480</name>
        <name evidence="3" type="ORF">LDBPK_181640</name>
        <name evidence="1" type="ORF">LdCL_180021700</name>
        <name evidence="2" type="ORF">LDHU3_18.2100</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="4" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000025">
        <property type="protein sequence ID" value="TPP50606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000027">
        <property type="protein sequence ID" value="TPP55192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860178.1">
        <property type="nucleotide sequence ID" value="XM_003860130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB96"/>
    <dbReference type="SMR" id="A0A3Q8IB96"/>
    <dbReference type="GeneID" id="13393466"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180021700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.2100"/>
    <dbReference type="OMA" id="GSTTMNH"/>
    <dbReference type="OrthoDB" id="274715at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="CDD" id="cd22648">
        <property type="entry name" value="Q4D6Q6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665:SF2">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39665">
        <property type="entry name" value="PARAFLAGELLAR ROD COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU78093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5429381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP55192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="118" mass="13226" checksum="E179E120C81E8BEF" modified="2019-04-10" version="1">MSEMNLIVNITCNPPVISIFGPIKESTIDRLNETIPNSCSTTNTGKTPFALVRKDDPPHWFGELRTQFATEDIGTSMLFISVLDALEEEGVWKLRGSTSLSHDCNKTTYKFFFVRGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBM3</accession>
    <name>A0A3Q8IBM3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_130005400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IBM3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_130040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.0060"/>
    <dbReference type="OrthoDB" id="264095at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="294" mass="32754" checksum="A9AA928A8A903A3A" modified="2019-04-10" version="1">MLDSCRSDASQALLRWGFSDAAAGSSANFALPPTDGTPTDGRQDTSPAYRASVISELLKQGKDSQQMLAVGKSAARETEELWRTAELEEYKLRLAQARNRLLRGRLAKLTRERHEQAQHVLLSHNQNSADIVGSKRAAASQIGPSPDDYDYTNDIVEARRQLDQCTKELEESQLRLHQLQQYHLGQLSGHLQPMMTANDALRTTENFLDPETNMAVRATVVDSLLEVNRALKPLSVQHDGLQSMEGVLPCLDNVATLWDRLAVQNFVVGRINRLFTCMCPTTPPLTLLKDTNMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICJ6</accession>
    <name>A0A3Q8ICJ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_26080</name>
        <name evidence="1" type="ORF">LdCL_250031200</name>
        <name evidence="2" type="ORF">LDHU3_25.3040</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICJ6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252530.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250031200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.3040"/>
    <dbReference type="OrthoDB" id="268503at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP48797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="261" mass="30470" checksum="2E33689C28777CA4" modified="2019-04-10" version="1">MAELLSKKTWRLRDVLFNEGTEQVVRVLKIDHPFRRQRITIVPTPRYAREAYLTDWVYQPYVKEHIMYVSNDIYNPFYVFLCRSLLRKGKFPEYAYFHPMGLPDCVDVNLSRRAFIKKEQPFKTPMSTILMTTNHFRDSHHPWVSRRTVNIVGEQYVVHPKEDKQSMVFVLPPAYVPDVVNTLQGLGFAVADTVTASIGDAAIINKLNSWSDKCQLLVLGYLWFLLALFIIGESRHIRQLFQDYKRELIEKAGKDPAKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICL4</accession>
    <name>A0A3Q8ICL4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_230010300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICL4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230010300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0700"/>
    <dbReference type="OrthoDB" id="312032at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32522">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32522:SF5">
        <property type="entry name" value="ABC3 TRANSPORTER PERMEASE PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="7">
        <location>
            <begin position="978"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122464" checksum="4D763EF21896CAE7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICT3</accession>
    <name>A0A3Q8ICT3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_170012300</name>
        <name evidence="2" type="ORF">LdCL_170012400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICT3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_170690.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170012300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1010"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42619" checksum="8235C8E8CA1B228F" modified="2019-04-10" version="1">MASEDIIIFLDALENTVNSIRGDGSAKKTLFTTGCVCPDGVGLDLSAYKDSKNPDDIVAWWGNIGAMKPCPGQKDGADWHDADGFLVRAPLFGGDAAVKRVEMTAPRSLIRGTAAFQAPGYPPLVTTVKQVALSRNGRAVFFCDREGHGVKKYNVDTKEVVPLLSSDVLAALADGLTEEEARASLVEPNSDEDKCRFCVGITLDEKHNQIFFTLKGPSKGGKGRILAAPYYFQRRHLASITAANTSTSEGVIDPKTVVTLLDHLPEPIDLLLDSEENYLYWTDRGDDAAGGNSLNRAPVTYDPCSGQPQLGERELLIRGFNEAIGLAWAANLVDCMRLPKNKETLRQYMYVTDMRHLWRCDLKARTKEVVYKCGPRNVLTGVEVLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICU2</accession>
    <name>A0A3Q8ICU2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_310039400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICU2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310039400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5320"/>
    <dbReference type="OrthoDB" id="266774at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="669"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="936" mass="102154" checksum="89BC09CBD723D70B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICY1</accession>
    <name>A0A3Q8ICY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter transmembrane region/ABC transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_240020300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240020300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1140"/>
    <dbReference type="OrthoDB" id="272342at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF273">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1231"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1351"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1491"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1593"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1626"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2371"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2441"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2547"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2640"/>
            <end position="2660"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1410"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1702"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="2385"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="2847"/>
            <end position="3301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="818"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="973"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2236"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2747"/>
            <end position="2837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3013"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3120"/>
            <end position="3157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="915"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2239"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2763"/>
            <end position="2787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2813"/>
            <end position="2826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU79235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="3330" mass="355613" checksum="430AF089CF3F742B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IED3</accession>
    <name>A0A3Q8IED3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MutS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_290023900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IED3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291840.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2640"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1096" mass="117913" checksum="DC9ACC138E0E2BE4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEK0</accession>
    <accession>E9BEB1</accession>
    <name>A0A3Q8IEK0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-related protein 2, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Actin-related_protein_2_putative/GeneDB:LmjF.19.1 200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_191190</name>
        <name evidence="2" type="ORF">LdCL_190017000</name>
        <name evidence="3" type="ORF">LDHU3_19.1430</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860294.1">
        <property type="nucleotide sequence ID" value="XM_003860246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEK0"/>
    <dbReference type="SMR" id="A0A3Q8IEK0"/>
    <dbReference type="GeneID" id="13386106"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191190.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190017000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1430"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="392" mass="43729" checksum="155DB2358E0B7AE6" modified="2019-04-10" version="1">MRLHRAQPLEKKALCGDDLAATGALAMVELTYPMRNGVVHNMDAMQVIWDYALCERLPALVGPSGGSTARWRYEDGLAWLQDRPLQLSEPPNMSLRQRCDLLGLFFEKYGLSAIQTVQQGILSLFANGTERGVVVECGEGLSHCTPVFDGFVLATAQRLVDVAGRAVTERLGQVLGHQQPHRRYQRRVPTGSDIGAMSHASWLFNDMNTLRQIKEHYCFVAHRRNGLEDRLTRETSALHRDCVLPDGTSCRLGPERFAAPEVLFNPQEIDHECDGIATALWKSIEAADIDVRAALYENIILSGGSTLLPGFGARLQREMKSFYLTEKLNGDPARMARCPIRVKEPQRRQHMVYMGGALLAELSQDQPERWLSRSAYEEGGTSAIIARYHGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEN2</accession>
    <accession>E9BEF4</accession>
    <name>A0A3Q8IEN2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein_kinase_putative/GeneDB:LmjF.19.1610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_191640</name>
        <name evidence="10" type="ORF">LdCL_190022200</name>
        <name evidence="11" type="ORF">LDHU3_19.1980</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860337.1">
        <property type="nucleotide sequence ID" value="XM_003860289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEN2"/>
    <dbReference type="SMR" id="A0A3Q8IEN2"/>
    <dbReference type="GeneID" id="13386148"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190022200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1980"/>
    <dbReference type="OMA" id="HLWEEDT"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC5429555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="278" mass="31361" checksum="2DF8DAF43BAEB727" modified="2019-04-10" version="1">MSARRSRLRRVRWLPHQRIVVLKEVDLWAEDCVTEGVDVVAERLWRMRMDASRNGRAQYLAEYLALHVDSSRHYQWLLSNYGPSLRDVLLTSSLTPFTEERCKGVLRRVLLALDQLHRVSMYVHADVSLGNVLTSPSSCDDVVLGDLESVSPIGAVPRGCLGSYLFMAPERLVDGALPLAPHDDIWAFGIVCYNLLTWDVTHPWCALGTESDHSENYWAFLDLMSKAKDVPPCQLLLQSPLSRCSKEALTFVAVCLSWDPACRPSAAELLQHSWMLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEZ2</accession>
    <name>A0A3Q8IEZ2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminomethyltransferase folate-binding domain/Glycine cleavage T-protein C-terminal barrel domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_240023700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEZ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240023700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2220"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="391" mass="42738" checksum="53B4BED1BBF1D178" modified="2019-04-10" version="1">MKPLVPFVCRLPSRRILRVRGTDVHEFLQGIFTNDLRELHPAGSMYGCFLYFTGRVLCDAHLYQCKQVHEGQASILVDVHERSAAGLFDHLTEMKMRKKVHIDDVGKELVVLATLEETFADAQRSSDSASGCDARASSVTPLSPETLEERHTECFPDPRNDALFTRPPPPSSSSSTSASDSVDTAAASATAAPPSSSPPAAVTPPSWFLRRCVVPATWAPPFSSPDPYTTLLYSRGIGEGPDVFKHNKSLPFEGNLDFLKGVSFHKGCYVGQELTHRTHVMLVTRKRTVPLHFGPASVDPPAAGAITDEGTVTKTRPVEVGEPLYSAAKEKIGEVTGVCGQVGIGLFRLRYVDKATRTVPGLQLKDGTPVQSHLPDWWPRKEVKKLLKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFA4</accession>
    <name>A0A3Q8IFA4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">VIT family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC21_28605</name>
        <name evidence="7" type="ORF">LdCL_290028400</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFA4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290028400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3200"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="296" mass="31395" checksum="207DA49424C6C196" modified="2019-04-10" version="1">MVDCASDRQYQARCAYGNPEKSIEIHGAKMETFNVDIRKNGAMRNRAMVLSGLAGLCTAAGTVAVAVGAPQLLGRLRGVRDAPCMILWTVAGGLCLAYVSTSSFSFERAIYDLEFRREMWEIENHLSGEVQEMLSIYKSQGLTEEEALIVTRIFARQKTVFANLMMVEELGYSRLEPPTTSEAVTNVGVPAVMGFVIGVATPLLCLAAALRASSCGQGSMSAGGGGVVCGPSAVTTQAKLLGASIFCMCTAVLSYVQTEVFFGAYAHAPVLLRTTVSNAAGIGSVFGLSYVAARWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFI5</accession>
    <name>A0A3Q8IFI5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGAP1-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350049300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350049300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5840"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="896"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1291" mass="145644" checksum="202B9ABEC9C8B6E4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFM0</accession>
    <name>A0A3Q8IFM0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_310024700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFM0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310024700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3010"/>
    <dbReference type="OrthoDB" id="267328at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU81374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="382" mass="42890" checksum="9374DDFE2EF13CF0" modified="2019-04-10" version="1">MASETSVALGVGVTLALFVLFAVALVFFGVYTNDSRTRSFEREREQRVELVRQRQRQEQEQWRERRLRDVVLLLIERGEALEGVSLAFQLPNRPEVSARRTLRSRRGVNSVRQNLEIELADEQENSRLDEEARRIARMPLHELLANGRPQNADAGPDVMQMLLDGQEIQRHTTSEDDSDFYLNDEDTTPASVTPFLSRQANEEARLGRGGGETAPPTPLQSAAPAPGQPQPQQGDGPTSTNVAAGEREIDARTAAVLLQEQRLRESRELALLQELRREKRRKYRKTAEEVYGQGADYEHNPANDALLRIQVVNGGGTPGSPLWRFLTPLTSLRGNRSRRDKKSAFDGLSPQESTVYQRENTGLPKSPASGKKKNRSFEVAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFP1</accession>
    <name>A0A3Q8IFP1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260012700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260012700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0910"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1735"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="930"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1737"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1793"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2038" mass="212775" checksum="E476A9025041E3E1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG44</accession>
    <name>A0A3Q8IG44_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_300041200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG44"/>
    <dbReference type="SMR" id="A0A3Q8IG44"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300041200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4740"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU81156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="392" mass="43126" checksum="656BAC1B5ED072B6" modified="2019-04-10" version="1">MSVHSILFSSEHVTEGHPDKLCDQVSDAVLDACLAGDPFSKVACESCAKTGMVMVFGEITTKAVLDYQKIVRNTIKDIGFDSADKGLDYESCNVLVAIEQQSPDICQGLGNFDSEDLGAGDQGMMFGYATDETETLMPLTYELARGLAKKYSELRRDGSLEWARPDAKTQVTVEYDYDTREGKQVLTPKRVAVVLISAQHDEHVTNDKISVDLMEKVIKAVIPANMLDAETKYWLNPSGRFVRGGPHGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSIVAGGLARRCLVQLAYAIGVAEPLSMHVETYGTGKYDDAKLLEIVKQNFKLRPYDIIQELNLRRPIYYETSRFGHFGRKDELGTGGFTWEVPKKMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHN6</accession>
    <name>A0A3Q8IHN6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_360052100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHN6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360052100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6100"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001266">
        <property type="entry name" value="Hypothetical_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="9">
        <location>
            <begin position="79"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="824" mass="93255" checksum="BDB47D0D75946F99" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHR3</accession>
    <name>A0A3Q8IHR3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_340039200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHR3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340039200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5170"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="392"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU82670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="664" mass="71753" checksum="F75C6A95FAB96DD9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8II62</accession>
    <accession>E9BJR7</accession>
    <name>A0A3Q8II62_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_13165</name>
        <name evidence="13" type="ORF">CGC21_22420</name>
        <name evidence="11" type="ORF">LDBPK_281960</name>
        <name evidence="9" type="ORF">LdCL_280024600</name>
        <name evidence="10" type="ORF">LDHU3_28.2570</name>
    </gene>
    <organism evidence="9 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 15" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="13">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862295.1">
        <property type="nucleotide sequence ID" value="XM_003862247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8II62"/>
    <dbReference type="GeneID" id="13387031"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281960.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280024600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2570"/>
    <dbReference type="OMA" id="WFPGTSG"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5431580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ35601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP40448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP54325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="225" mass="25548" checksum="4AE8FBC72C306C02" modified="2019-04-10" version="1">MSDIFPESHPEHPLNLIPELCRKFYDLGWATGTGGGISIKMGENYYIAPSGVQKERIMPNEIFVLNASQDVVEEPRTEKQLKISECTPLFFNAYRLRGAGACLHTHSANCVLISLLCDREFRISHIEMIKGIINNETKKALGFRDTLVVPIIENTDFEKDLTASMAECMERYPESCAVLVRRHGMYVWSDTWQKAKGAVECIDYLMGLAIRMRTLGLEWEPKDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIU7</accession>
    <accession>E9BN63</accession>
    <name>A0A3Q8IIU7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_2725</name>
        <name evidence="6" type="ORF">CGC21_10820</name>
        <name evidence="4" type="ORF">LDBPK_312930</name>
        <name evidence="2" type="ORF">LdCL_310037600</name>
        <name evidence="3" type="ORF">LDHU3_31.5100</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000005">
        <property type="protein sequence ID" value="TPP41335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863378.1">
        <property type="nucleotide sequence ID" value="XM_003863330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIU7"/>
    <dbReference type="GeneID" id="13389712"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312930"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310037600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5100"/>
    <dbReference type="OMA" id="TIKECTM"/>
    <dbReference type="OrthoDB" id="273662at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="624" mass="66740" checksum="4E24E52DF1E2D106" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJA6</accession>
    <name>A0A3Q8IJA6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DREV methyltransferase, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DREV_methyltransferase_putative/GeneDB:LmjF.30.11 00</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_300016800</name>
        <name evidence="2" type="ORF">LDHU3_30.1500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJA6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1500"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="307" mass="34936" checksum="AFE69132A68E1603" modified="2019-04-10" version="1">MQGLSKDLQLYISGHRGRPALIYEPRTSLVEPSLLQLFEACNCDAETTAFLIRSRNMSVWKLMLADFLSVFLSRTTAQGMVGRGMMFVYSTEQIRRLLRPPQAPLVSPLPPDFQFDSLLDIGAGDGGVTANIAPLFKKVYVTEFSASMRWRLRRRGYEVLPHDDPFHMNTAERLLDRRYFDVIACNNVLDRADMPETLLREMRDSLKPNGLLVLAVVLPWCPFVEDGPRQKRPSEILPMQGGECCRGASFEQSMSKLVENVLVPMGFEVVRWTRLPYLCEGNLRIEYAVLNDAVFILRKRGDVESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJA9</accession>
    <name>A0A3Q8IJA9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 4 gamma, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360070600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJA9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360070600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8370"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="758" mass="83949" checksum="F2211CBE4A5E9FE4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IKC7</accession>
    <accession>E9BN43</accession>
    <name>A0A3Q8IKC7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_10925</name>
        <name evidence="3" type="ORF">LDBPK_312730</name>
        <name evidence="2" type="ORF">LdCL_310035300</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863360.1">
        <property type="nucleotide sequence ID" value="XM_003863312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IKC7"/>
    <dbReference type="GeneID" id="13389692"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310035300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4840"/>
    <dbReference type="OMA" id="WPSVEGP"/>
    <dbReference type="OrthoDB" id="261190at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="577" mass="60246" checksum="C1323A8AEE096EE1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IL41</accession>
    <accession>E9BFA3</accession>
    <name>A0A3Q8IL41_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_22345</name>
        <name evidence="16" type="ORF">CGC21_34245</name>
        <name evidence="15" type="ORF">LDBPK_211170</name>
        <name evidence="13" type="ORF">LdCL_210016800</name>
        <name evidence="14" type="ORF">LDHU3_21.1380</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860634.1">
        <property type="nucleotide sequence ID" value="XM_003860586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IL41"/>
    <dbReference type="SMR" id="A0A3Q8IL41"/>
    <dbReference type="GeneID" id="13386437"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1380"/>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="266388at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000086">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5429852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP49341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP54676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="132" mass="13905" checksum="45EDD0DA38EDC56C" modified="2019-04-10" version="1">MATPRSAKKSARKSGSKSAKCGLIFPVGRVGGMMRHGQYARRIGVSGAVYLTAVLEYLTAELLELSVKAAAQSGKKRCRLNPRTVMLAARHDDDISSLLKNVTLSHSGVVPNISKAMAKKKGGKKGKATPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILM4</accession>
    <name>A0A3Q8ILM4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dopey, N-terminal, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_320042000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_323610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320042000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.4560"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1 N-terminal" evidence="6">
        <location>
            <begin position="289"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1469"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2935" mass="310212" checksum="A31C995CD2558FB8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMR4</accession>
    <name>A0A3Q8IMR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Amastin-like surface protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Amastin-like_surface_protein-like_protein/GeneDB: LmjF.24.1250/GeneDB:LmjF.24.1280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16250</name>
        <name evidence="2" type="ORF">LdCL_240017900</name>
        <name evidence="3" type="ORF">LdCL_240018200</name>
        <name evidence="4" type="ORF">LDHU3_24.1550</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMR4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240018200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1550"/>
    <dbReference type="OrthoDB" id="256081at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF4">
        <property type="entry name" value="AMASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5430461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="186" mass="20057" checksum="61385AFFD265A9CE" modified="2019-04-10" version="1">MPACLAYYTGAMCFTIIHFLAWAFAFVATPTAQFQTPGHGCYTMWGYRQFCGNVPYDLTGDAAFGCARRTSTMRCGAAFGVMASVCGFAGLVSAIVLNTQIQFPVIVPFVLAAVCIPCTMISWACVASVYNLTMCGDRFGSKYPYTAGFALMVASWGLELIAVVILACTTWTRPPKEEENAADAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IMS0</accession>
    <name>A0A3Q8IMS0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_350043600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IMS0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_353850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350043600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5020"/>
    <dbReference type="OrthoDB" id="274958at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="147" mass="17720" checksum="85C3840C2AFF6B9C" modified="2019-04-10" version="1">MSQLWVKRAKAEMTRHSRVLETINRVFPMPFEERRSRVGMTSYATYRWLRYFPVILVPVVVMGTLLETRDNPQEHVFTSLHLWLADHGVFRHDTVKALNPAFEDERRSIEWKTNDRKWRFTGMDMPSEREIREFAAINIDRQSRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IN54</accession>
    <name>A0A3Q8IN54_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, putative</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_350059100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IN54"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_355070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350059100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.7100"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF649">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35735" checksum="7A42D74AE4CF1AA9" modified="2019-04-10" version="1">MLIVYNIGTAVGYIVVIGEIFTPMLPVIRLYVPWLSSSSHIMIASWSLVMLPLSCLPKVSHLYVTSFLAIAATFFISGIIVYRYFVPLSSAPAARNSEEDIKYFCVSRRSLLALPVVMFAFDCQSLVFQVWTELAYPSRGSMAKVATVSVLVTSLVYGVVGFFGYMANTPHVHGNILTNYDPMRDRLFAIGETFYSITVNVAYVLILIPCRDAIFQMWYGFSHTHESLEIPHHSNLLVSVLLSFFCLCLALLAPGFLYIVALMGAFCSSTLCFTYPALFRQRLHILGLAPYAGYERLAVWAMYFFGFSGAMMGFFVLVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IP44</accession>
    <accession>E9BIC0</accession>
    <name>A0A3Q8IP44_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_5045</name>
        <name evidence="5" type="ORF">CGC21_31880</name>
        <name evidence="4" type="ORF">LDBPK_261080</name>
        <name evidence="2" type="ORF">LdCL_260016400</name>
        <name evidence="3" type="ORF">LDHU3_26.1360</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812646">
        <property type="protein sequence ID" value="CAC5430945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000018">
        <property type="protein sequence ID" value="TPP51992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861695.1">
        <property type="nucleotide sequence ID" value="XM_003861647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IP44"/>
    <dbReference type="GeneID" id="13388941"/>
    <dbReference type="KEGG" id="ldo:LDBPK_261080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_261080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260016400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1360"/>
    <dbReference type="OMA" id="DIKWMMN"/>
    <dbReference type="OrthoDB" id="275747at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5430945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP41145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP51992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="126" mass="14614" checksum="C394AE9CB6595A54" modified="2019-04-10" version="1">MLRRTQASLFRRTPVRLSGGELYHPPKLEDIPPSSATKGFFGAYNGGLVMLRFIDLKWMMNRAVELGREYYISAPTLYLFLWMFCWKGFVIMRYGDGNPPRHVDWNTEEAGYLPQGFEQTKVTKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IQY7</accession>
    <name>A0A3Q8IQY7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LdCL_280036400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_283110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280036400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.4120"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000013">
        <property type="entry name" value="Dynein Heavy Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000007">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000015">
        <property type="entry name" value="Dynein heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000010">
        <property type="entry name" value="Dynein heavy chain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000017">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000019">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002429">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000020">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000014">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000014">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1489"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1771"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2130"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1203"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2742"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2972"/>
            <end position="3020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYU80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="4227" mass="474160" checksum="87B835C49DB8E988" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IS34</accession>
    <accession>E9BV84</accession>
    <name>A0A3Q8IS34_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CGC20_18615</name>
        <name evidence="19" type="ORF">CGC21_38845</name>
        <name evidence="17" type="ORF">LDBPK_367280</name>
        <name evidence="15" type="ORF">LdCL_360085400</name>
        <name evidence="16" type="ORF">LDHU3_36.9660</name>
    </gene>
    <organism evidence="15 21">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="17 20" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 21" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 21">LdCL</strain>
        </source>
    </reference>
    <reference evidence="22" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">FDAARGOS_360</strain>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="23" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5435316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000001">
        <property type="protein sequence ID" value="TPP49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865838.1">
        <property type="nucleotide sequence ID" value="XM_003865790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IS34"/>
    <dbReference type="SMR" id="A0A3Q8IS34"/>
    <dbReference type="GeneID" id="13386693"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360085400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9660"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF246">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE-LIKE 1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044516118" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="340"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU84134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC5435316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CBZ39163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TPP53385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="477" mass="52358" checksum="B3C9C363498B9C2C" modified="2019-04-10" version="1">MQRSFLAFVVCAILFCVASAEVQVATKDNFDKIVSGDLTLVKFYAPWCGHCKTLAPEFIKAADMLAGIATLAEVDCTKEESLAEKYQIKGFPTLYIFRNGEKVKDYDGPRTAAGIASYMKAHVGPSIKAISKAEELEELKKETFPVCVVKTASADSEMASMITKVADSLRTQMNFVLVTDAAISPNDAMESVTVYRKNAEREAYTGAAPMTAESVKRFLATAVLDYFGELGQESFQKYMEANKGKPLGWVFVDKNTDPALKGSLVAVAEKYRSQVLLTFIDGDQYRPVSRQLGIPEDAKFPAFVVDFERRHHVMETYTPVTAESVAAFVEKYIKGETKQTLMSDAIPAKETVNGLTTVVGQTFAKYTDGTQNVMLLFYAPWCGHCQKLHPVYEKVAKSLESENVIIAKMDATTNDFDREKFEVSGFPTIYFIPAGKPPIVYEGGRTADDIKAFVKSHLTASAAPSGGPSGNSDEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IST7</accession>
    <accession>E9BN14</accession>
    <name>A0A3Q8IST7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_312440</name>
        <name evidence="2" type="ORF">LdCL_310032400</name>
        <name evidence="3" type="ORF">LDHU3_31.4420</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812651">
        <property type="protein sequence ID" value="CAC5432667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863331.1">
        <property type="nucleotide sequence ID" value="XM_003863283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IST7"/>
    <dbReference type="GeneID" id="13389663"/>
    <dbReference type="KEGG" id="ldo:LDBPK_312440"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_312440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.4420"/>
    <dbReference type="OMA" id="PEMEMEY"/>
    <dbReference type="OrthoDB" id="273040at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5432667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="538" mass="58200" checksum="EA2B7A79E87F6173" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IWH0</accession>
    <name>A0A3Q8IWH0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_360068200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IWH0"/>
    <dbReference type="SMR" id="A0A3Q8IWH0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360068200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8010"/>
    <dbReference type="OrthoDB" id="270207at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="231" mass="25145" checksum="DE930C406D0F54BB" modified="2019-04-10" version="1">MRCFSTKSTASKEGFHGSASGKGSNSVPVKSSALFIEALSKRRTIYNLGNKLSQSHKEVIEIIEGTIRECPSSFNIKSSTVVILFGADHQKVWNIVKAALKKVTSEEQYAQSEMKVNNSFAAGAGTILFYEDGAAIKMQQKAFPRYAANVPTFSQQSSAMAQFAVWSALAQDGIGASLQHYNELIEADLRAAFDVPEEWQLIAQMPFGSIETPADKKARNSDEGRVVVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5V9</accession>
    <name>A0A3S5H5V9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallo-peptidase, Clan ME, Family M16C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_070006000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H5V9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0140"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000057">
        <property type="entry name" value="Pitrilysin-like metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000080">
        <property type="entry name" value="Pitrilysin-like metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000106">
        <property type="entry name" value="Pitrilysin-like metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="4">
        <location>
            <begin position="496"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115406" checksum="99C7D7A53C1CF6F7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H5X1</accession>
    <name>A0A3S5H5X1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_070007900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0360"/>
    <dbReference type="OrthoDB" id="273557at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000021">
        <property type="entry name" value="Putative ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="5925"/>
            <end position="6266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="867"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="960"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1312"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1389"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1634"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1751"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1789"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1880"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2094"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2268"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2325"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2566"/>
            <end position="2637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2953"/>
            <end position="3091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3464"/>
            <end position="3538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3612"/>
            <end position="3638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4140"/>
            <end position="4261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4301"/>
            <end position="4459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4594"/>
            <end position="4725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4746"/>
            <end position="4791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4920"/>
            <end position="4945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="5085"/>
            <end position="5107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="5126"/>
            <end position="5164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="5640"/>
            <end position="5668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="5602"/>
            <end position="5630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="867"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="914"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1394"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1634"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1645"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1816"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1884"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2098"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2123"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2292"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="2338"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2567"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2955"/>
            <end position="2970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2972"/>
            <end position="2986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2994"/>
            <end position="3013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="3026"/>
            <end position="3035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="3039"/>
            <end position="3056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="3466"/>
            <end position="3477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="3508"/>
            <end position="3522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="3612"/>
            <end position="3621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="3622"/>
            <end position="3631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="4155"/>
            <end position="4164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="4223"/>
            <end position="4240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="4316"/>
            <end position="4364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="4399"/>
            <end position="4409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="4419"/>
            <end position="4452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="4594"/>
            <end position="4606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="4610"/>
            <end position="4641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="4656"/>
            <end position="4665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="4679"/>
            <end position="4691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="4716"/>
            <end position="4725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="4771"/>
            <end position="4782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="4920"/>
            <end position="4938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="5126"/>
            <end position="5140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="5653"/>
            <end position="5668"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="6233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU76197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="6266" mass="671125" checksum="CB3123709B64204B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6J6</accession>
    <name>A0A3S5H6J6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_110016900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6J6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110016900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1310"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF448">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="174"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="323" mass="36233" checksum="7B7980322CB1E1C5" modified="2019-04-10" version="1">MDVASRSKLDEASGGSIKGNAVFEASGRHDACAVANVLAPPPKIDAAGGNVVEVDHGAADSDHGFESRSEQPLASCCVDTRRYPDSWRHTRPRRYAFERPLHSYQIAGQMYCLVVIILFWSSVFAAYVLLYTQDKQDCLAELVAFSTLFGAGVVCVYMFFFWLSFKDCTDRSNSGELCMFCRRRTHVDSKHCKACNKCVEGFDHHCKWLNVCVGRENYIAFFCFVSGSVFTSFTTLGSVICLLARWWHVLAERHSAYFRAGPVVLCIVLLVGIVPIVHLFGFHIYLHFILRTTTYQHIVGKREETFQIPAEEAAPKKTSCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6T4</accession>
    <name>A0A3S5H6T4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter aATP11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_140021900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6T4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0450"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF301">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="111"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="506" mass="55709" checksum="1419C54D2A5DC3C3" modified="2019-04-10" version="1">MPTAATGKSAMPYPNESAHGHEWEYDSPNRDGAELLEEQAYAAEVEGHKKKAAATSEDSQKGVDPFDFSVNSPEQRIARMDRERAERVQRRRTELNFFQRWFSYILPYGGVVASGINLASSCIGAGIIALPSAFNAAGIIVAMIYMVVIAYLTIYSYILLAIVAKKTGLRNYEQIARTLMGPGAGYFLAFCLWFLSFGAEVSYAISLKDVLTAFLDASETAPAYLQTLSGQRVMTFVLWLVAMLPLCLPKEINSLRYFSCVAIVFIVYFVIAMVVHSAQNGLRADPRPEIRMFTTGNTAVSGMSTFIFAFLSQLNAYESYEEMNNPTPLRLTLGATISVGIVFVLYFLAGLFGYLDFGTEMTGSALKKYNPVKDVMMGVGYVGILFKLCVGFGLHMIPVRDAIYHCVRVDVHTFAWWKNACVCAFMALLSLVAGLFIPSINVVFGLVGGFSGGFIGFIYPSFMVMYSGNWSLSSVGWFHYLSTYFLLIVGVVGVVWGTASSIYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6T6</accession>
    <accession>E9BC49</accession>
    <name>A0A3S5H6T6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_1900</name>
        <name evidence="4" type="ORF">LDBPK_150080</name>
        <name evidence="2" type="ORF">LdCL_150005700</name>
        <name evidence="3" type="ORF">LDHU3_15.0110</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859533.1">
        <property type="nucleotide sequence ID" value="XM_003859485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6T6"/>
    <dbReference type="SMR" id="A0A3S5H6T6"/>
    <dbReference type="GeneID" id="13392896"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0110"/>
    <dbReference type="OMA" id="YEPWEHM"/>
    <dbReference type="OrthoDB" id="277583at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="CDD" id="cd23643">
        <property type="entry name" value="mS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059199">
        <property type="entry name" value="mS23-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP47798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="321" mass="36665" checksum="7B22DB9389420934" modified="2019-04-10" version="1">MRRSSSCLYKIPKNMGVAPRFDTWNEKYEPWEHLKRMGRLAGTGFYIPPEWYNHFRMFPPINHNFQQEKTLNPHNASEPTQDDTDHLSVERIALRDELARKSRLLASEGMRYYNVFWIRKPLDRMERHYYELKRKGVAHSVAIKRVLQMFYDDLTVKKRVAAIQAEEAKLSGKYISMREATVLMGVLTQLQKEQLTPHQVTLLAKEQREKAQAGEAFAATVERSTETVADAAKDAAEGDEVMSADSLAELLSTEADLDDSSPSISYKVTIHETEHDSVKQLQELALDHTGKSDWYTGASPVLHVEEPMPTKRTPASKQTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H763</accession>
    <name>A0A3S5H763_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pteridine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_190014100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H763"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190014100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1070"/>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF51">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="673" mass="73683" checksum="0E7C153AE66CC04D" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7B8</accession>
    <name>A0A3S5H7B8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_17390</name>
        <name evidence="2" type="ORF">LdCL_230011900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7B8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230011900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0890"/>
    <dbReference type="OrthoDB" id="272219at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP50295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="344" mass="37263" checksum="EB85B8196612796A" modified="2019-04-10" version="1">MSAPTASAMRLVMDSAASDNGNNSSVMQTPVPPTGTTLFLREEGSRTFVPVYHQSSVTLRDLAEEFNISSVLECDAHGNVQPRAVAFDSPSDVLHSGRHYIARRDARAEAGNSYVTFRGKILVKEYELEHPTPPASRNIETPTIAGDGVESASLAHKIYSAPAATPFPDKPSVRQGYNEEYRSSISRALALSSERKRPREDASRTSAEGSAASEGCQQRSQAQRTEEPQLSSATLPGSESVLQDCTNGACAPLTLPGKSSNVQSSSETAMEDISIDEPAQRSLRFIPFSETASDGSETYVTLEDLQRLCQEAATQEEEFQKRHNAATDILESARRVLFTTGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7C2</accession>
    <accession>E9BGE5</accession>
    <name>A0A3S5H7C2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_17945</name>
        <name evidence="4" type="ORF">CGC21_17070</name>
        <name evidence="3" type="ORF">LDBPK_231310</name>
        <name evidence="1" type="ORF">LdCL_230020200</name>
        <name evidence="2" type="ORF">LDHU3_23.1710</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861024.1">
        <property type="nucleotide sequence ID" value="XM_003860976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7C2"/>
    <dbReference type="SMR" id="A0A3S5H7C2"/>
    <dbReference type="GeneID" id="13390224"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1710"/>
    <dbReference type="OMA" id="CTMRCVS"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5430264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP50231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP51297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="487" mass="54004" checksum="35D30094ECDBDD05" modified="2019-04-10" version="1">MLSQSSGTPFTGEIPDKETLHEVMRYMPYNRRTLTAMRCVSRPFRSAVQSPQSPWAPHKEIMVSRYGQCIIFNAQEDERGRSNYSLYSISSIGRKFRTHSAKLLGRYHALVANGLSRLVLHHAPVENSFFEPLGALTNLRELELVSCRGVTSLGDASRIKSLESLTIVFCPVEPDGVSGLHLSNLKKLTLRSCSKLSNLNAIHSETCASLVDVHVESCGVYDDTSSAFFSDLSSNLRTLDLTATFIDTALTQIPKEALESLTTLLMSETPLHSMTLNTLKTSLAKNLVHLSLDGCEEIADLSALGSLKKLRFLDVSRLSVLQDIECVAQCTQLEMFRCAATDLNNITFLKNMEHLRVLDATNTALTDYTLIHLEESPELDTVVLTGCLYISSINAFHQCPKIRRILCGRTAVTNEGVEMLTECATLEELDLKMTNVTDVNRLADCPSLKVINVCGSIMMQDAIQRLLDKPSVEVICDSFEEGDYMDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7C5</accession>
    <accession>E9BGK1</accession>
    <name>A0A3S5H7C5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC20_17705</name>
        <name evidence="8" type="ORF">CGC21_16820</name>
        <name evidence="7" type="ORF">LDBPK_231870</name>
        <name evidence="5" type="ORF">LdCL_230025900</name>
        <name evidence="6" type="ORF">LDHU3_23.2460</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812643">
        <property type="protein sequence ID" value="CAC5430320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000023">
        <property type="protein sequence ID" value="TPP51249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861079.1">
        <property type="nucleotide sequence ID" value="XM_003861031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7C5"/>
    <dbReference type="GeneID" id="13390517"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230025900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2460"/>
    <dbReference type="OMA" id="MPNNQVS"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001209">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5430320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP50181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP51249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="220" mass="23819" checksum="B07456D0671A96BA" modified="2019-04-10" version="1">MEILKKTAAFRVQKQVEGRPAEEVTQLSLSGVPALPELWSPYTHLTHLLLICMKPKLVSLDILGLNKLQALRLLDVSDNAVAVTSPPPAVPSLVRLLMPNNQVSSLEEVSRLAQSFPNLEVLDVVDNDVDTPAHFASVFGAFPKLVALNSRTRDGTEVVVEDSDETDSDEECEDSSDEESDDEVGQTGSSGSTGSETEEESEGDAEPTAKRTRTEDEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7F0</accession>
    <name>A0A3S5H7F0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Not1 N-terminal domain, CCR4-Not complex component/NOT2 / NOT3 / NOT5 family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LdCL_250024900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7F0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250024900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2380"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000014">
        <property type="entry name" value="Not1_N-terminal_domain_-_CCR4-Not_complex_component/NOT2_/_NOT3_/_NOT5_family_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="503"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU79528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="634" mass="71762" checksum="34EC26B6A77A7BCC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7G8</accession>
    <name>A0A3S5H7G8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260028800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7G8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260028800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3020"/>
    <dbReference type="OrthoDB" id="272738at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="774"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137452" checksum="DAC66985262142E4" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7X6</accession>
    <accession>E9BRB4</accession>
    <name>A0A3S5H7X6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_26895</name>
        <name evidence="8" type="ORF">LDBPK_343160</name>
        <name evidence="7" type="ORF">LdCL_340040500</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP40225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864475.1">
        <property type="nucleotide sequence ID" value="XM_003864427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7X6"/>
    <dbReference type="GeneID" id="13387354"/>
    <dbReference type="KEGG" id="ldo:LDBPK_343160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_343160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340040500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.5330"/>
    <dbReference type="OMA" id="CVTIHSE"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000049">
        <property type="entry name" value="Glucose-6-phosphate 1-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP40225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="301" mass="33097" checksum="3A1A5576E3CC42E0" modified="2019-04-10" version="1">MVAFTPDSRGRNCVTIHSEDGSSVTVYEQGAHVSSWKTKDGKEHLYLSPTAIFADRTALRGGVPLIFPQFGAYGPLQPSHGFARIRSWSIEDAQSGRASFSLRVPLCELLPEDSSLTDSPQSAVNLLYTICFSNTELKLRMKVTNTSEEQSAPFQFAFHTYFAVSDVSKTVVSGVNRSPFVDNCKARGNPNTQPSPPEQLWIIRGEHDRVYPDQACAIVLQDLGTKTTLQISSPNLSDVCLWNPGESKCAAMKDMPPDGYKHFVCVEHGKMLKKVVVPPCSSWTGTQEIAIIAESPRESNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WP68</accession>
    <name>A0A3S7WP68_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_050012400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029504">
        <property type="protein sequence ID" value="AYU75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WP68"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_050730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_050012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_05.0820"/>
    <dbReference type="OrthoDB" id="265509at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="741" mass="80139" checksum="B7BAF9085E335E1E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPU9</accession>
    <accession>E9B916</accession>
    <name>A0A3S7WPU9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_1005</name>
        <name evidence="7" type="ORF">CGC21_10245</name>
        <name evidence="5" type="ORF">LDBPK_070200</name>
        <name evidence="3" type="ORF">LdCL_070009400</name>
        <name evidence="4" type="ORF">LDHU3_07.0530</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000059">
        <property type="protein sequence ID" value="TPP45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858462.1">
        <property type="nucleotide sequence ID" value="XM_003858414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPU9"/>
    <dbReference type="GeneID" id="13391785"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070200.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070009400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0530"/>
    <dbReference type="OMA" id="MEIAYTK"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIN1-type PH" evidence="2">
        <location>
            <begin position="381"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="512" mass="57175" checksum="F24371F56CECA01F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPW4</accession>
    <accession>E9B960</accession>
    <name>A0A3S7WPW4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_1110</name>
        <name evidence="6" type="ORF">CGC21_10350</name>
        <name evidence="4" type="ORF">LDBPK_070670</name>
        <name evidence="2" type="ORF">LdCL_070011600</name>
        <name evidence="3" type="ORF">LDHU3_07.0810</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029506">
        <property type="protein sequence ID" value="AYU76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812627">
        <property type="protein sequence ID" value="CAC5427582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799594">
        <property type="protein sequence ID" value="CBZ31783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000059">
        <property type="protein sequence ID" value="TPP45280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000029">
        <property type="protein sequence ID" value="TPP52479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858506.1">
        <property type="nucleotide sequence ID" value="XM_003858458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPW4"/>
    <dbReference type="SMR" id="A0A3S7WPW4"/>
    <dbReference type="GeneID" id="13391807"/>
    <dbReference type="KEGG" id="ldo:LDBPK_070670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_070670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_070011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_07.0810"/>
    <dbReference type="OMA" id="AVYPTVH"/>
    <dbReference type="OrthoDB" id="273080at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="195" mass="20139" checksum="73B841082C85C484" modified="2019-05-08" version="1">MLNCFFGAELKPDGVPISFTIPKGTTLVITQCAVTSVVPPQQSTDAGASSSPAVAAKAYSPVTLCVQGHGLPTRFAVCSLSPAQHITYCPLQLLFSKPVSFVLVPQTGSTAAAGASSSPSPAPHPGKKTRRNQKHNKTAAGAHGAGAEATAAYPTVHLTGYYERAADEDEEDGSMAMDAMESSDDGENDDLSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ47</accession>
    <name>A0A3S7WQ47_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-activating enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_080007200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQ47"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080007200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0290"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000669">
        <property type="entry name" value="SUMO-activating enzyme subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000864">
        <property type="entry name" value="SUMO-activating enzyme subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000014">
        <property type="entry name" value="Ubiquitin-activating enzyme-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="275"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="4">
        <location>
            <begin position="896"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1095" mass="113750" checksum="B31FA3B07E081E53" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQ83</accession>
    <name>A0A3S7WQ83_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080011300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0700"/>
    <dbReference type="OrthoDB" id="273869at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35614:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2042"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2114"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2306"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2358"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2653"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2807"/>
            <end position="2891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1748"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1843"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1881"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2118"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2170"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2228"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2375"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2417"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2439"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2457"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2502"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2547"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2590"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2657"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2675"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2818"/>
            <end position="2831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2851"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2870"/>
            <end position="2880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2891" mass="305182" checksum="C873D37797E9B619" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQQ7</accession>
    <name>A0A3S7WQQ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_090013500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090013500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0960"/>
    <dbReference type="OrthoDB" id="2104158at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1998"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2194"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2272"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2358"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2530"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2644"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3061"/>
            <end position="3083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3607"/>
            <end position="3630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3738"/>
            <end position="3788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3853"/>
            <end position="3894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3959"/>
            <end position="3984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4236"/>
            <end position="4282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4565"/>
            <end position="4611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4702"/>
            <end position="4742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4986"/>
            <end position="5023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5131"/>
            <end position="5161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5204"/>
            <end position="5299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5313"/>
            <end position="5343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="2002"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2014"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2221"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2282"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2536"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2663"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3607"/>
            <end position="3622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3860"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3959"/>
            <end position="3971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4257"/>
            <end position="4281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4579"/>
            <end position="4591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4702"/>
            <end position="4715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4725"/>
            <end position="4737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="5004"/>
            <end position="5017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="5131"/>
            <end position="5145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5146"/>
            <end position="5155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="5204"/>
            <end position="5218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="5242"/>
            <end position="5261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5266"/>
            <end position="5279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="5459" mass="566159" checksum="BBBD7436EBF76342" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRV5</accession>
    <name>A0A3S7WRV5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_120008500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0460"/>
    <dbReference type="OrthoDB" id="267941at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1793"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1985"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1870"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1902"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1922"/>
            <end position="1931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2005" mass="206343" checksum="23CD92A921E8566E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRY5</accession>
    <accession>E9BB40</accession>
    <name>A0A3S7WRY5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY4 N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_27480</name>
        <name evidence="4" type="ORF">LDBPK_120600</name>
        <name evidence="3" type="ORF">LdCL_120011700</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799599">
        <property type="protein sequence ID" value="CBZ32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000046">
        <property type="protein sequence ID" value="TPP53917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859177.1">
        <property type="nucleotide sequence ID" value="XM_003859129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRY5"/>
    <dbReference type="GeneID" id="13390130"/>
    <dbReference type="KEGG" id="ldo:LDBPK_120600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0930"/>
    <dbReference type="OMA" id="HSYDRTA"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059022">
        <property type="entry name" value="MINDY4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26038">
        <property type="entry name" value="Dimer_MINDY4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY4 N-terminal dimerisation" evidence="2">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="617" mass="64135" checksum="86C8991745BAC18A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WS54</accession>
    <name>A0A3S7WS54_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_120018800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU77047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120018800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.1400"/>
    <dbReference type="OrthoDB" id="266284at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1697" mass="180121" checksum="7F1CE61A240807B9" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSL9</accession>
    <name>A0A3S7WSL9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_130018100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSL9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1540"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="837" mass="90986" checksum="F720C524E22DCDB2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSS0</accession>
    <accession>E9BBL9</accession>
    <name>A0A3S7WSS0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_33585</name>
        <name evidence="2" type="ORF">LDBPK_131560</name>
        <name evidence="1" type="ORF">LdCL_130018700</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859356.1">
        <property type="nucleotide sequence ID" value="XM_003859308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSS0"/>
    <dbReference type="GeneID" id="13390783"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131560.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130018700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1610"/>
    <dbReference type="OMA" id="CCQRMVL"/>
    <dbReference type="OrthoDB" id="263223at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP45226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="246" mass="27172" checksum="39C0E4BFBF758FBA" modified="2019-05-08" version="1">MRSALITSILEKVENEVRQRLHDAAALTSPGPSSAVAPPTLLSLLTPEDWSAVRRSLREDATLPPIAASATDEVESASASFQPAAASELLQYVQMRCAELPMRLQIEALLTRRYEHLLRQHTRELVTLSEHMALISRTPPTLAPAPRGFSEPAPNLAQLPVDVRALLAEEEMGPRLERCQARICDLEAMARQDAEAKVRCCQRMVLLSEFVQALVRHAMAHVLKGEEEPKSNAAVATKRPRTEQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSZ0</accession>
    <name>A0A3S7WSZ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_140011200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSZ0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.0800"/>
    <dbReference type="OrthoDB" id="273805at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="260" mass="28641" checksum="E734FFEB3493ECAC" modified="2019-05-08" version="1">MTSKGSPVRSGASLTADELEEKLATLHNYLSTPYRARAEAILQRRRQREARASLNRSHKVLQGPEGANPGRVPLERVSVPFHSPASIQNPSPAEKKGNSVEKAPDESRMRVAADISTTPTEFKSKCDSEDEVSKRDGSSGLSEPSPTACAPAQALPMDPHTRRYVQQLEWQVKMLADALQQERERLAEVDARVVQPLLRLADAALQQQVQLECALASCRARERDERGPLREEVCSERDVNLLCKSLGDILKEGREGSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WTR7</accession>
    <name>A0A3S7WTR7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MORN repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_160006000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WTR7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0120"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="698" mass="77196" checksum="C616F9104CBB468C" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WU24</accession>
    <accession>E9BCW9</accession>
    <name>A0A3S7WU24_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide cyclase / dehydrase and lipid transport, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Polyketide_cyclase_/_dehydrase_and_lipid_transpor t_putative/Pfam:PF03364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_161150</name>
        <name evidence="6" type="ORF">LdCL_160016600</name>
        <name evidence="7" type="ORF">LDHU3_16.1410</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812636">
        <property type="protein sequence ID" value="CAC5428975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859802.1">
        <property type="nucleotide sequence ID" value="XM_003859754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WU24"/>
    <dbReference type="GeneID" id="13393202"/>
    <dbReference type="KEGG" id="ldo:LDBPK_161150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_161150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160016600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.1410"/>
    <dbReference type="OMA" id="REHCTIG"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5428975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="370" mass="39560" checksum="EA75DF77F24FF18C" modified="2019-05-08" version="1">MELSRLLHRYHSSSSTVSAPATTSSNELPGTRREEGLLPPLPPPPQQQQAAGNSTVAKAQAAIAAAAALKRHVNTSASLTASSASSTRPEAADGAAGSPTHGCKAATSQAYRASSSSSDSRHHVQVYREHCTIGWSPDEFYSVVADVEHYSAFLPWCAGSEVHTTRRVRVPRDARRLPPSPAAAASPLATGCEAAESELVDAIEMTTTLTIGFSFLKEQYTSRVTLYPGRKIVAALYDEEDVDVEAAPQNTSRASSAAAALSRDSNSALGTGSGDGFVLSFFRKAASTAGVAAKRSILRHLRCEWEFAPVEGKPNTVDVLFFVSFEFKNPMYRHLIMNNVVGLMTRSFERRCESLYGPPSATKVSLPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUJ9</accession>
    <accession>E9BDE4</accession>
    <name>A0A3S7WUJ9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_37525</name>
        <name evidence="4" type="ORF">CGC21_4215</name>
        <name evidence="3" type="ORF">LDBPK_171220</name>
        <name evidence="1" type="ORF">LdCL_170018300</name>
        <name evidence="2" type="ORF">LDHU3_17.1710</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="8" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000030">
        <property type="protein sequence ID" value="TPP51744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000040">
        <property type="protein sequence ID" value="TPP55060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859977.1">
        <property type="nucleotide sequence ID" value="XM_003859929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUJ9"/>
    <dbReference type="GeneID" id="13393255"/>
    <dbReference type="KEGG" id="ldo:LDBPK_171220"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170018300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1710"/>
    <dbReference type="OMA" id="PVHEDIN"/>
    <dbReference type="OrthoDB" id="260688at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5429175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP51744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP55060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="118" mass="13982" checksum="74C4BF17282919C9" modified="2019-05-08" version="1">MLRSLHRAAPLAVTATTTTLSTPAVPFALQTAARTKYVRQPSAQWDPVHEDINAHVKRRIPGETRVDRVRRFAREWRNVELELGVYKDSRGREIKYRKTFVYRYTYPNAFDEFWWPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUN9</accession>
    <accession>E9BDG8</accession>
    <name>A0A3S7WUN9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LDBPK_171460</name>
        <name evidence="9" type="ORF">LdCL_170020800</name>
        <name evidence="10" type="ORF">LDHU3_17.1980</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812637">
        <property type="protein sequence ID" value="CAC5429199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799604">
        <property type="protein sequence ID" value="CBZ33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860001.1">
        <property type="nucleotide sequence ID" value="XM_003859953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUN9"/>
    <dbReference type="GeneID" id="13393279"/>
    <dbReference type="KEGG" id="ldo:LDBPK_171460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170020800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1980"/>
    <dbReference type="OMA" id="FYQAAGH"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF25">
        <property type="entry name" value="CYTOCHROME B5 HEME-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044600653" evidence="7">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC5429199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19281" checksum="47E89DBD9341EFC4" modified="2019-05-08" version="1">MLEHDWSGGVLAVLALLVVTACGVISSCDVCGLSIVKQVMAPSDRSDGGVPEATAVRSSPSTATETPMLELDDRPRGAAAGKANKYVEEFYQAAGHLRCPQLQRYTQEEVARHRTKDDLWIVVDSNVLNVSAFVPHHPGGDVILDGVGGQDMATVFAYFHDPSTVRLMLSFCIGRILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVC7</accession>
    <accession>E9BE58</accession>
    <name>A0A3S7WVC7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Core histone H2A/H2B/H3/H4 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Histone H3 variant, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Histone_H3_variant_putative/GeneDB:LmjF.19.0630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_9015</name>
        <name evidence="8" type="ORF">CGC21_19275</name>
        <name evidence="6" type="ORF">LDBPK_190630</name>
        <name evidence="4" type="ORF">LdCL_190011300</name>
        <name evidence="5" type="ORF">LDHU3_19.0710</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812639">
        <property type="protein sequence ID" value="CAC5429449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000033">
        <property type="protein sequence ID" value="TPP41818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000027">
        <property type="protein sequence ID" value="TPP51004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860241.1">
        <property type="nucleotide sequence ID" value="XM_003860193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVC7"/>
    <dbReference type="GeneID" id="13386053"/>
    <dbReference type="KEGG" id="ldo:LDBPK_190630"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190011300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0710"/>
    <dbReference type="OMA" id="RKYQHST"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000077">
        <property type="entry name" value="Histone H3 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="53"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5429449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP41818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP51004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="145" mass="16519" checksum="AA24FEA03BB4FFF1" modified="2019-05-08" version="1">MAGVTKAAVVASHPKKNVASRKMNKKSRSMAKKEAKAMRGGTADSKRRRHWRPGTVALREVRKYQHSTEMLIARSPFRRLVKEIMSTFKDTMHMRHSALEAMQDATESYLVSLLSDANLCTIHAKRVTLYPKDLQLALRLRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WVU1</accession>
    <name>A0A3S7WVU1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_200010400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WVU1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200570.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0680"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000435">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="358"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="552" mass="59483" checksum="E2C2F8CBFE144DA5" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWC8</accession>
    <name>A0A3S7WWC8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210008500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWC8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210370.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210008500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0390"/>
    <dbReference type="OrthoDB" id="248669at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018988961" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34727" checksum="8FBA83780F328DAD" modified="2019-05-08" version="1">MACLLLALCILPDPAAAVVGSLNGASARSPSVAPHIGDLVPLSMYIRTKRQIRHSFISVADQQLAVDEEAVVDDAAGNVEAATAAEVLRPKDLDLPSLGATRGKHKNQVVRLLPPASSPRFGINKAVTIVANSTLRAAGQSLQEDTALQQSDLAFRFSVGRGLHKESTWLPLAARKKYTSQLSETLAGRLHEMQAAQAADAAAERQRDKEAAEAMDNTAAAAAAQKVQYLSRVTFFFGYRKGDLQKMTSFSIAAQYSPEVKPGVELQFLWSEHRPYNPNRAVTLCSAVAVLVSMITVLAVFHPSSRSMLLFSQRIVAVRAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXK3</accession>
    <name>A0A3S7WXK3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_230011600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WXK3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0850"/>
    <dbReference type="OrthoDB" id="264829at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="882" mass="93615" checksum="19F003FBA94FD230" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXX8</accession>
    <name>A0A3S7WXX8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA polymerase theta (Helicase domain only), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LdCL_230023600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230023600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2200"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000004">
        <property type="entry name" value="DNA polymerase theta (Helicase domain only), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="887"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="670"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1464"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1477"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1868" mass="194810" checksum="D6F253AB2FB80517" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY05</accession>
    <accession>E9BGI0</accession>
    <name>A0A3S7WY05_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ran-binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ran-interacting Mog1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC21_16905</name>
        <name evidence="5" type="ORF">LDBPK_231660</name>
        <name evidence="4" type="ORF">LdCL_230023800</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000022">
        <property type="protein sequence ID" value="TPP50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861059.1">
        <property type="nucleotide sequence ID" value="XM_003861011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY05"/>
    <dbReference type="GeneID" id="13390259"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230023800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2220"/>
    <dbReference type="OMA" id="ECSSAWM"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="213" mass="23237" checksum="3829C100C9253168" modified="2019-05-08" version="1">MAATHTVDLYGGAMRISLPQTMIDVSDFRQVPDNQEVYTDADTGASVIVELLRRQTHVCNFEAGAFFYHDLAKDNGCAPESISQEETCTLPPSAFPLLATSAAPAAPAECGPVAPQSCDFACLTTGLQRISKYTNEKGKENEVFVGLAVLRFTPPVSTEILVSVSCPTWLHPESSEARVVKRLLTEQERLQLLYTAVASLEVVEWGLFVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYM4</accession>
    <name>A0A3S7WYM4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_240028200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYM4"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_242260.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240028200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2780"/>
    <dbReference type="OrthoDB" id="270484at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="5">
        <location>
            <begin position="96"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="4">
        <location>
            <begin position="774"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112532" checksum="D05BE3A1DEFEE4A0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ62</accession>
    <name>A0A3S7WZ62_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_250020600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ62"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250020600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1840"/>
    <dbReference type="OrthoDB" id="271488at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU79485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9842" checksum="A32469FFE30824F9" modified="2019-05-08" version="1">MYATATTVHRNRRPYPPQDTSKHYTEVPPATVRQCNAIHRIIKRLGREVAFDEYEPVEKVVVVIIFLLIVTLAIGGPMYIICYALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0K2</accession>
    <accession>E9BJ10</accession>
    <name>A0A3S7X0K2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC20_32930</name>
        <name evidence="6" type="ORF">CGC21_31020</name>
        <name evidence="4" type="ORF">LDBPK_270760</name>
        <name evidence="2" type="ORF">LdCL_270014200</name>
        <name evidence="3" type="ORF">LDHU3_27.1180</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_360</strain>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861932.1">
        <property type="nucleotide sequence ID" value="XM_003861884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0K2"/>
    <dbReference type="GeneID" id="13389193"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1180"/>
    <dbReference type="OMA" id="KEKCCIP"/>
    <dbReference type="OrthoDB" id="267284at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP46102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP47562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="196" mass="22472" checksum="2A4DB1E30D9CE44A" modified="2019-05-08" version="1">MESRTKFKADTPVQLPPAIDPVREHYPFCIVWSPIPVLSWILPFVGHTAVCDSQGRIYDFQGAYRIGQDRMLFGNPVKYWDVSRDYIPSFYNADQHNSAEREEAVKREVAAYDAALMSTISHFRQTEVYNFFTNNCHSFVAASMNEQQLKKQHMGIVSIAIGMMRHGRYISFSRFLKAHLPSVLLVVIILILATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1I0</accession>
    <accession>E9BJM2</accession>
    <name>A0A3S7X1I0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amastin surface glycofamily protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Amastin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_22215</name>
        <name evidence="4" type="ORF">LDBPK_281510</name>
        <name evidence="3" type="ORF">LdCL_280019800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862250.1">
        <property type="nucleotide sequence ID" value="XM_003862202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1I0"/>
    <dbReference type="GeneID" id="13386986"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1930"/>
    <dbReference type="OMA" id="NLSSWVM"/>
    <dbReference type="OrthoDB" id="266115at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297:SF6">
        <property type="entry name" value="AMASTIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33297">
        <property type="entry name" value="AMASTIN-LIKE SURFACE PROTEIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP54284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="540" mass="57801" checksum="D6C6C409FC92B9B4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1K8</accession>
    <name>A0A3S7X1K8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280021100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1K8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2110"/>
    <dbReference type="OrthoDB" id="267665at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17521" checksum="40DC0A48752BF9C0" modified="2019-05-08" version="1">MAPKAKPDRMAGGPSSASKSATDPMLQGTYEQDESNDLEASTDEIAAFEARLRHQQQHGRGNSAAARNISSAPTSGAPRRSSAPVTNSAHRPHPSSSAAPSAAAGASYAAPHRTADRGASEEEHAAQTQRGEDIEDVRRLEDRFRGGDDDDSDEETVARRRKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2L6</accession>
    <name>A0A3S7X2L6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_290021100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290021100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2260"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000056">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000040">
        <property type="entry name" value="Putative phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019185772" description="1-phosphatidylinositol 4-kinase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="2658"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="2070"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="2356"/>
            <end position="2642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU80647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2658" mass="290505" checksum="52592CCD45D45B6D" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2W2</accession>
    <name>A0A3S7X2W2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_300005600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2W2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0110"/>
    <dbReference type="OrthoDB" id="275697at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="240" mass="27847" checksum="55B1722FFD191F2A" modified="2019-05-08" version="1">MQRCLARLFQAGVHTPHGSRYNAARMKNWPVQEVPQNFSFTNEQRFKAKAVPRDTGKIPRDFLLSVLYRNQPCEVASLWEHCLNDPQIVLDSKRHLREVLQQARAEGFVSFEKDAVTDRWVCHLTRERFEEVRALVGARAEAQDLYSGLRGASAKETSAYSESFREMNEDTKREHLRLLSEQVADTTTHLRKFQRMEMDYLPYTDLNGKVNFMWWYEMSDTRDATALPEAAAEGSPKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4J0</accession>
    <name>A0A3S7X4J0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MYND finger containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_310023900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4J0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310023900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.2920"/>
    <dbReference type="OrthoDB" id="3202243at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU81366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="478" mass="53827" checksum="1DB92CC327620369" modified="2019-05-08" version="1">MTDESRDSSPETGDDRPPVNHDSVLRYPFREMRMEWFDDYMDNISPSKRVAVATRLMDCLMAHTVLHEDPFLEKAVTFIYNRVATHETFRNMTGVFGEAHDVFRIVCMTAKFTVSNASEKNALLNLLDQHCTRFQAAAQKTKSESSETLIAAAGHVTECVCSLRKNMASAEAFRRLMDSIKFLFFTVNTRNGVSPYSSNGKLLFNTFVCCDGCPCYAKLRTGPTVFLRDMEKIKVLDCVMIAAVNAKDARMHDTTSKFLHNFCKDFMENPHLDDIGHLVHNGRLFYCRTALFDALDNIESISSPQSDIADLPSAKTFTLDRIVLALLWVKSEVKEIRLLCNLVPTLNEALSSAEAAYSRLDCEDVLQVVYTLKEHILAVFLALSAPEYHLAVHSRDVFVGKQADMKCASPSCPGTTKDLLKCSGCDVTFYCSPECQKADWDKHKNFCHEIESRRSQPASPTIVYGPVQVLKPVSRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4Y8</accession>
    <name>A0A3S7X4Y8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_310039700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_313140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310039700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.5350"/>
    <dbReference type="OrthoDB" id="266368at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1587"/>
            <end position="1619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1777" mass="187386" checksum="C4649CB889081DE3" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6U6</accession>
    <name>A0A3S7X6U6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330028500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6U6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330028500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3130"/>
    <dbReference type="OrthoDB" id="272761at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19511" checksum="E34B327813B14500" modified="2019-05-08" version="1">MSAHGPSEVAAAAESTPMSSSLSSSSPSSSLPAPSAVGTLPACCTEAFKEHYRRGEVPRFGCYDPVYLRQAFDTSPTLDSAMRNPTHASFFPPFSYLVRTYADHGAASSSSPLASRIAGGAPAVDEDADQDAVTLTADRARPVHSWEHITSAEDMWNGPPLTMKVPPASDYERILLDRPPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7B0</accession>
    <name>A0A3S7X7B0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation transporter, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Cation_transporter_putative/GeneDB:LmjF.33.3200</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">ZIP Zinc transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_9755</name>
        <name evidence="6" type="ORF">LdCL_330041100</name>
        <name evidence="7" type="ORF">LDHU3_33.4830</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812653">
        <property type="protein sequence ID" value="CAC5433543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000006">
        <property type="protein sequence ID" value="TPP55357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7B0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330041100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4830"/>
    <dbReference type="OrthoDB" id="1100342at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5433543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP55357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="334" mass="35522" checksum="E0065D6462239C75" modified="2019-05-08" version="1">MTHNGTPWPPSCEATENENYSSAWHVVALFVILGCSLLGTVLPILGKRVSAFRVPEYAYAIGKSVATGVVLGVALIHMLKPANESLTSDCMPSALRNFSKPLAYIICIASVAAMHSLEACLRVFFDGFGAVRDLPIASGESQHLLSGSQAGGHHFHPSAPAFDSWKSSGGLQILSAVLLEFGVSLHSLFVGLTVGMCADAELYTLMCALSFHQFFEGVALGSRLVDAALTLRTEYVLAAVFVLSAPLGTAVGIMCVCEHIINTKGSMYLLTQGILDSVCAGILLYIGFQLLVGDFYADMQSTVHNVRSPRGFLLAMLVALWAGVSIMALIGQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X7Y3</accession>
    <accession>E9BQY0</accession>
    <name>A0A3S7X7Y3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_341810</name>
        <name evidence="1" type="ORF">LdCL_340025700</name>
        <name evidence="2" type="ORF">LDHU3_34.3110</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864341.1">
        <property type="nucleotide sequence ID" value="XM_003864293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X7Y3"/>
    <dbReference type="GeneID" id="13392750"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341810.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3110"/>
    <dbReference type="OMA" id="ARREYNP"/>
    <dbReference type="OrthoDB" id="272254at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5433764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="315" mass="33660" checksum="E48C3FEC47D9B00F" modified="2019-05-08" version="1">MSCAQVDMSDTQAAPSRAKSRRTCAVYFGATTFVEIDDDPSTITLEELCEAFGTPWESGMHVKHRATGRVVVTLPFEPLPTLEEVSDVIIKAESTTATTHTGDLTVPTAYDNAEEDVDGAEEGETTYAVVYDLVTPTPPGDNGDSELAAAVAAAGLSENLSADSDGASNIGETMRKLVELGAAELLTAEPLSVSQARREYNPPDAPGLLRRIVYPASEYSPYRLDRDPLYDGKLSLYRSPAVTASFASGPSPVSCTGSHALPTQDFGEGGLYTSYLDSYDLSCPMREPFVRSFAAGKAALVMPLSDEEHHRIFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8Q7</accession>
    <name>A0A3S7X8Q7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Generative cell specific 1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LdCL_350009600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X8Q7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0610"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018928">
        <property type="entry name" value="HAP2/GCS1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10699">
        <property type="entry name" value="HAP2-GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Generative cell specific-1/HAP2" evidence="13">
        <location>
            <begin position="146"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="868"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU82846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="917" mass="97756" checksum="72619546F98C7088" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAL6</accession>
    <accession>E9BTK0</accession>
    <name>A0A3S7XAL6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Adenylate kinase, putative</fullName>
            <ecNumber evidence="5">2.7.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_13010</name>
        <name evidence="6" type="ORF">LDBPK_361410</name>
        <name evidence="5" type="ORF">LdCL_360019600</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865257.1">
        <property type="nucleotide sequence ID" value="XM_003865209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAL6"/>
    <dbReference type="GeneID" id="13388142"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1790"/>
    <dbReference type="OMA" id="TIAHFST"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ38579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP48252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="220" mass="24775" checksum="69A2C32C7964C4AC" modified="2019-05-08" version="1">MPLFIILFGPPGSGKGTVSHLLVKEYGFVHLSAGNLLREEVLKKSPLGLRCAEIMSEGSLIPDELVVDLVCNRLSEPAAQKHGILLDGFPRTLRQAEVLRARGFKFDMMILLDVSPEILLNRCLSRRLDPVTGRIYNLKSDPPSPDVVDRLQIRSDDTKEKHERRMQIYNSQKATLIAHYSDIIIEIDADPEINVVFKELQKKINKRLQGTTTQVPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAL8</accession>
    <name>A0A3S7XAL8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360018100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAL8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360018100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1640"/>
    <dbReference type="OrthoDB" id="272477at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035155">
        <property type="entry name" value="DUF5393"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17371">
        <property type="entry name" value="DUF5393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="773" mass="82440" checksum="8B89D58785DFE049" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XB69</accession>
    <name>A0A3S7XB69_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_360040600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XB69"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_363380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360040600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.4640"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU83691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="536" mass="58099" checksum="D9D0449BAFDD9402" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XC77</accession>
    <name>A0A3S7XC77_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(A)-specific ribonuclease PARN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360074100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XC77"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_366630.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360074100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.8800"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000347">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000300">
        <property type="entry name" value="Poly(A)-specific_ribonuclease_PARN_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="510" mass="58413" checksum="55F3B4493FB12577" modified="2019-05-08" version="1">MDITRFNQLVALPDFAREVERCEFCAIDQEMTGVDVTGVSAPFGAPPEAVYHAKRAAVVVYNAFQMGIALFTKTENNTYEVRPYNFYLLNDSGDLRLNLSVVSFLAANHLNFQTWLTSGLPFCNEQEEAAYEEKLQMPFTDHAEQQIADALIEAIDEWMPAGNEPLVRELPCVIDLARRLQSFLYRRYDSRIAVNYDGKPYLGQKIKFTLTKLDTNEWISEKEKRRLQCERDRGQQLGFRLFWKILVQSRKPIVGHNFMQDVMFMIHMHETPISQDYLEFKKVLQRTLPSIYDTKTMATKLTGDDAFPVTHLEPLYQECRRRAGFSSDQFTQEYRLPPGFYGYNDSAVKLQSKAHEAAYDAYMTGIAFSLMHKLYPGAFMEMKNFISAFGSAYFFCVDTDDQLVNPSTFILKCAVPCHSEEIEALFFATEDITTKATENGKVDMKKLSYQVNGLAISEGAKNYSSFCVRMKQAMGIDDLHRRLQSLRDKELSPSTNVNPLLLDLITLHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XCH5</accession>
    <accession>E9BV68</accession>
    <name>A0A3S7XCH5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CG1104 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_38780</name>
        <name evidence="4" type="ORF">LDBPK_367120</name>
        <name evidence="3" type="ORF">LdCL_360083800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000055">
        <property type="protein sequence ID" value="TPP53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865822.1">
        <property type="nucleotide sequence ID" value="XM_003865774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XCH5"/>
    <dbReference type="GeneID" id="13386677"/>
    <dbReference type="KEGG" id="ldo:LDBPK_367120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_367120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360083800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.9490"/>
    <dbReference type="OMA" id="FRCHVEV"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP53372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="737" mass="80351" checksum="4116B0D46B218676" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJ63</accession>
    <name>A0A451EJ63_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">propionyl-CoA carboxylase</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LdCL_010005500</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJ63"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0070"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0092">Biotin</keyword>
    <keyword evidence="5 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="5"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="124"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYU75516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="665" mass="73891" checksum="AD3F2FF672763168" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJH1</accession>
    <name>A0A451EJH1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_020008600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJH1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020008600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0430"/>
    <dbReference type="OrthoDB" id="273887at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114862" checksum="7B7F6CAD0CE231C0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>E9BCM5</accession>
    <accession>A0A3S7WTS6</accession>
    <name>E9BCM5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial ornithine carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LDBPK_160210</name>
        <name evidence="11" type="ORF">LdCL_160007000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029515">
        <property type="protein sequence ID" value="AYU77598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799603">
        <property type="protein sequence ID" value="CBZ33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859709.1">
        <property type="nucleotide sequence ID" value="XM_003859661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BCM5"/>
    <dbReference type="GeneID" id="13393081"/>
    <dbReference type="KEGG" id="ldo:LDBPK_160210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_160210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_160007000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_16.0270"/>
    <dbReference type="OMA" id="VYRESGW"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="PhylomeDB" id="E9BCM5"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000099">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="96"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="192"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU77598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CBZ33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32536" checksum="4695339B39A96ADD" modified="2011-04-05" version="1">MGLWNDFVAGTAGGCAGVLIEHPFDTIKVLLQTYGGTRYTGYTDCVTKLFRQDGVIGFYRGVTARLFASGFEHAWVLATYKWTLRLIGAGDRPTLPQILLGGCGSGVAATLCLTPFELVKCRLQADDSKGQRRYRGSLDCAQQVVREHGFKGLYKGGFAMLCREVPGSVAWCGTYDTLKSWMTPEGVPTQSLPLWKLMIAGGCSGVAFWTAFYPSDLVKTRIQVDPAYEKLSLWGAMTRVYQKEGLRALYRGWTLTAARSFPSNAVIFGVFDSCNRALSCESTLTADVPSTLSGHGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGS9</accession>
    <accession>A0A3S7WY64</accession>
    <name>E9BGS9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_240670</name>
        <name evidence="1" type="ORF">LdCL_240011700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861157.1">
        <property type="nucleotide sequence ID" value="XM_003861109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGS9"/>
    <dbReference type="GeneID" id="13390843"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240011700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.0800"/>
    <dbReference type="OMA" id="SWMGYRS"/>
    <dbReference type="OrthoDB" id="252468at2759"/>
    <dbReference type="PhylomeDB" id="E9BGS9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="762" mass="84105" checksum="AA6CBFB518A31109" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGV0</accession>
    <accession>A0A3S7WYC1</accession>
    <name>E9BGV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_16070</name>
        <name evidence="4" type="ORF">LDBPK_220690</name>
        <name evidence="3" type="ORF">LDBPK_240880</name>
        <name evidence="2" type="ORF">LdCL_240013800</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861178.1">
        <property type="nucleotide sequence ID" value="XM_003861130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGV0"/>
    <dbReference type="GeneID" id="13390864"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220690"/>
    <dbReference type="KEGG" id="ldo:LDBPK_240880"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_240880.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240013800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.1040"/>
    <dbReference type="OMA" id="PCCVLGF"/>
    <dbReference type="OrthoDB" id="242944at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="344" mass="37805" checksum="AF718EE5E672351E" modified="2011-04-05" version="1">MRAAPTRLAPSTAVPLCGSHCGSRAYHFAAAGAAGWRRRRRLAGVSVTTTHTVAPAVSALPFSLSTARRTYYWPYPENLVPEGATASPFQSSPVPSVRERIIREYALGPLFGSRTPCCVLGFADTARDVVACKRDVRRWVARALGKSEADVELGSLVQAKEMLLHRSGTDESPRLGDGPGSRPDAERRRVTRYARLPVQARTLLEVYLPGEEHGEVDAAADADAVILAHGYFLQEQLHRHMTTTASSGTDPTVLSDSEGSQREKPVRKLQSHCQGYSERNDEADVESSVAALHDVCGVIYCEVPVLDESDFVFDQLCGKEVDEETTERVTDRWTRRVMQQQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>E9BH48</accession>
    <accession>A0A3Q8IMV3</accession>
    <name>E9BH48_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_241860</name>
        <name evidence="5" type="ORF">LdCL_240024200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861276.1">
        <property type="nucleotide sequence ID" value="XM_003861228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BH48"/>
    <dbReference type="GeneID" id="13391198"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240024200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2290"/>
    <dbReference type="OMA" id="VQFFADC"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="PhylomeDB" id="E9BH48"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26560" checksum="3E9E923A3100BE62" modified="2011-04-05" version="1">MDSDLSAEIARIEAELAQDAELRQQQQQQQQQLAPQLSQQPPASLFGFGQTAPAQPQQQQQQLFHTQPPQPQQQPSNPFNVNASPFMPTPQQPDYSQQQQQQQQPIGSAGQAAAQACAPTPIIHSFSKDTDSRSIFIGNLPRGTDGTPATTPEELVQFFADCGNILNCTVLKDRATGEPKGTAYIEFADYTAMGKAIDTKNNANFKGSTIIVCVSTSPIFYLQVSSVKLLKPMQRPRAWRGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJC1</accession>
    <accession>A0A3Q8ICU1</accession>
    <name>E9BJC1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_271910</name>
        <name evidence="3" type="ORF">LdCL_270026300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862042.1">
        <property type="nucleotide sequence ID" value="XM_003861994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJC1"/>
    <dbReference type="GeneID" id="13386777"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271910"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270026300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.2890"/>
    <dbReference type="OMA" id="IADAYCI"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="PhylomeDB" id="E9BJC1"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000098">
        <property type="entry name" value="Rab-GTPase-TBC domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF212">
        <property type="entry name" value="RELATED TO THE N TERMINUS OF TRE ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="400"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1025" mass="108228" checksum="140CC4A5E65D282F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BJK4</accession>
    <accession>A0A3Q8IQI6</accession>
    <name>E9BJK4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_281330</name>
        <name evidence="2" type="ORF">LdCL_280017900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862232.1">
        <property type="nucleotide sequence ID" value="XM_003862184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BJK4"/>
    <dbReference type="GeneID" id="13386968"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1680"/>
    <dbReference type="OMA" id="GCTYGVC"/>
    <dbReference type="OrthoDB" id="240081at2759"/>
    <dbReference type="PhylomeDB" id="E9BJK4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="49640" checksum="163256B23934B99D" modified="2011-04-05" version="1">MSISATAPVGKWVIVRSDRLVLSVDKTDHVYVVGRGRQLPSAQLLSHKYASREHLAVVWHPPHLYMIQEGKNPSFLGASCTPVPRLNDAAAVESDESAPSLWQRAPVRFSATAAAKEATAHQSAGGIITVDVPLCDPLTVTQAPDRHAIDAATVHFPEELALPTLTVRFEGTEVAREDATAAATTRTTAEMLAVPSVRALGGGDDDNDELSDEERKASRPSNGRTGGGEGAAAANGSGKPGWRGLLDVALQQQQQQDMSDSSPAAQVKEARSESQRSLGAVAPSAQAPFGSASEKAPAPACADPAPHKLGIWEWKNHIEGKGSDPMPWRKYNLAVAALLEKAYQDTSLAKIKIPDSAMFGKPDAKGYTYGVCFAEKALDGAMIQYSLKEPSKFCVIRRTGGPPVDRKRAKKAHVIASPPSSEDSESNSEDSCSDDSEAEESAISSSLSINSSTSSDGTPPKKRRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9BLV9</accession>
    <accession>A0A3S7X3K9</accession>
    <name>E9BLV9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_302160</name>
        <name evidence="3" type="ORF">LdCL_300027100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862928.1">
        <property type="nucleotide sequence ID" value="XM_003862880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BLV9"/>
    <dbReference type="GeneID" id="13385636"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300027100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2920"/>
    <dbReference type="OMA" id="MVDGHIC"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="PhylomeDB" id="E9BLV9"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042411">
        <property type="entry name" value="WDR27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="851" mass="89384" checksum="25225C0FD400A4C7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSV0</accession>
    <accession>A0A3S7X9T5</accession>
    <name>E9BSV0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptojanin (N-terminal domain), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_354300</name>
        <name evidence="4" type="ORF">LdCL_350048100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865008.1">
        <property type="nucleotide sequence ID" value="XM_003864960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSV0"/>
    <dbReference type="GeneID" id="13387886"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354300.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350048100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.5690"/>
    <dbReference type="OMA" id="YLPCEAL"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="PhylomeDB" id="E9BSV0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="465"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ38329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110584" checksum="D9F72EE7C2484FAE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I9X0</accession>
    <accession>E9BC25</accession>
    <name>A0A3Q8I9X0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_5120</name>
        <name evidence="3" type="ORF">LDBPK_141430</name>
        <name evidence="2" type="ORF">LdCL_140020200</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000026">
        <property type="protein sequence ID" value="TPP46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859510.1">
        <property type="nucleotide sequence ID" value="XM_003859462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I9X0"/>
    <dbReference type="GeneID" id="13391377"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141430.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140020200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1780"/>
    <dbReference type="OMA" id="PESMPSQ"/>
    <dbReference type="OrthoDB" id="272310at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ32801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="622" mass="66075" checksum="A0FC865C70FFCFD1" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICC8</accession>
    <name>A0A3Q8ICC8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_220014700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICC8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.1190"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000017">
        <property type="entry name" value="Prp18 domain containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="443"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="552" mass="58723" checksum="AF703DBDB170C879" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICT6</accession>
    <accession>E9BI71</accession>
    <name>A0A3Q8ICT6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPR repeat/Pentatricopeptide repeat domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC21_31685</name>
        <name evidence="6" type="ORF">LDBPK_260580</name>
        <name evidence="5" type="ORF">LdCL_260011500</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861646.1">
        <property type="nucleotide sequence ID" value="XM_003861598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICT6"/>
    <dbReference type="GeneID" id="13388892"/>
    <dbReference type="KEGG" id="ldo:LDBPK_260580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260580.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.0770"/>
    <dbReference type="OMA" id="NCYSEMR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF24">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="148"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU79660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="395" mass="43656" checksum="09C0A1D0BD082309" modified="2019-04-10" version="1">MYRCGLPLSTPRHVPAALAHSGKGVVRRNGGATWTARRSFTSSTTLRSYPPVSELPSSTPAAPSPLPFISAFTASDAAETAAVPSADTSSPLGTGTTAAATATVNDLHGDEVPLNTPAEVEEAFACSVQARTVSNVQLRRYIDHLPPKDYSLALAAVKGAKAAGLRISASTYEALLSSLMSGGQLRASMELYQVMIKQHMAPTPNMYAALMEMCLQRGMPKACQSLFDDMQQRGVRPAARNYELMITSLSAEVPPQWARAIEVFDRISRERRSRITAKTYNALMRVYMNMDPFDWRVVYNCYSEMRNRRPRVPLEWESYLILCEALRKGNAGYVRRGMAYIDAWIAVTPLRSWNFLIGAMAYLAFMMVLKSIVGYFVVWYYESSVPSTSDSVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ICZ3</accession>
    <name>A0A3Q8ICZ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_130019600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ICZ3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130019600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1720"/>
    <dbReference type="OrthoDB" id="267427at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="877"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1057" mass="110915" checksum="7AFE241F78BB68CC" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDG3</accession>
    <name>A0A3Q8IDG3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain in Dock180 and Zizimin proteins, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_290006000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290006000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0160"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000008">
        <property type="entry name" value="Tb-292 membrane associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000415">
        <property type="entry name" value="Tb-292 membrane associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052293">
        <property type="entry name" value="SRRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239:SF41">
        <property type="entry name" value="MEMBRANE ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239">
        <property type="entry name" value="PROTEIN CBG20215-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1503"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2300"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1515"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2300"/>
            <end position="2318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2596" mass="295195" checksum="1BD0DAC014D3E805" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDQ1</accession>
    <accession>E9BK50</accession>
    <name>A0A3Q8IDQ1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_280100</name>
        <name evidence="2" type="ORF">LdCL_280005900</name>
        <name evidence="3" type="ORF">LDHU3_28.0130</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862111.1">
        <property type="nucleotide sequence ID" value="XM_003862063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDQ1"/>
    <dbReference type="GeneID" id="13386847"/>
    <dbReference type="KEGG" id="ldo:LDBPK_280100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280005900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0130"/>
    <dbReference type="OMA" id="YRSTWRV"/>
    <dbReference type="OrthoDB" id="269837at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="77" mass="9220" checksum="5468DBEC60B82677" modified="2019-04-10" version="1">MKQPYRSTWRVYLPGLFVMSIFSVVVYFSRTRSDVVKYGYDFVPIYSEDGKLEGFTHPVLVKAGNQYREMEEERRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE14</accession>
    <name>A0A3Q8IE14_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Holliday-junction resolvase-like of SPT6/SH2 domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_330040100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333250.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330040100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4730"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000023">
        <property type="entry name" value="Holliday-junction_resolvase-like_of_SPT6 /SH2_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000113">
        <property type="entry name" value="Holliday-junction_resolvase-like_of_SPT6 /SH2_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Spt6 YqgF" evidence="3">
        <location>
            <begin position="695"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6 SH2" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1457" mass="163256" checksum="573CB2B85DE8E15A" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IE31</accession>
    <name>A0A3Q8IE31_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ciliary BBSome complex subunit 2, N-terminal/Ciliary BBSome complex subunit 2, middle region/Ciliary BBSome complex subunit 2, C-terminal, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_300011200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IE31"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300610.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300011200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0790"/>
    <dbReference type="OrthoDB" id="2120021at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055381">
        <property type="entry name" value="BBS2_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23351">
        <property type="entry name" value="BBS2_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14782">
        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="8">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="7">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="10">
        <location>
            <begin position="522"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 C-terminal helix bundle" evidence="9">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU80857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="654" mass="71303" checksum="4A8DE60EBE3E6B08" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEA5</accession>
    <name>A0A3Q8IEA5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_340020700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340020700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2240"/>
    <dbReference type="OrthoDB" id="272187at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2377"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2380"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2434"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2455"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2495"/>
            <end position="2505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2611" mass="276919" checksum="0E7E0780B73CC9A9" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEE6</accession>
    <name>A0A3Q8IEE6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_190007800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_190280.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190007800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.0320"/>
    <dbReference type="OrthoDB" id="265803at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1367" mass="145305" checksum="19D59CA45EF3AFDA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEJ3</accession>
    <accession>E9BKD9</accession>
    <name>A0A3Q8IEJ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_281010</name>
        <name evidence="1" type="ORF">LdCL_280014700</name>
        <name evidence="2" type="ORF">LDHU3_28.1220</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862200.1">
        <property type="nucleotide sequence ID" value="XM_003862152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEJ3"/>
    <dbReference type="GeneID" id="13386936"/>
    <dbReference type="KEGG" id="ldo:LDBPK_281010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_281010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280014700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.1220"/>
    <dbReference type="OMA" id="MRYYLAN"/>
    <dbReference type="OrthoDB" id="239319at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5431481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="189" mass="22390" checksum="1A6EA52FED9D2ED2" modified="2019-04-10" version="1">MFWTSTVLCARALVDRKSPQLWGAPGAPIIRMRGHHVTWKFQSYDMFVEHTHRRRNSDIRLLHYLGKHCPHPQKSLWSPDTPVTQDRHLFMLTTIDVDAFKYWFGVKRCRLSVGPWNILAKSGLLPPSHKQNSKIMPKPIFDKEQLMRYYLANRKDQRQMEREDYLNYKNSMVKSPEERAAERPVAPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFD0</accession>
    <accession>E9BFM0</accession>
    <name>A0A3Q8IFD0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_16765</name>
        <name evidence="6" type="ORF">CGC20_7720</name>
        <name evidence="5" type="ORF">CGC21_32905</name>
        <name evidence="4" type="ORF">LDBPK_220010</name>
        <name evidence="2" type="ORF">LdCL_220006200</name>
        <name evidence="3" type="ORF">LDHU3_22.0190</name>
    </gene>
    <organism evidence="2 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812642">
        <property type="protein sequence ID" value="CAC5429974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799609">
        <property type="protein sequence ID" value="CBZ34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000032">
        <property type="protein sequence ID" value="TPP45396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000032">
        <property type="protein sequence ID" value="TPP52541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000030">
        <property type="protein sequence ID" value="TPP54141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860751.1">
        <property type="nucleotide sequence ID" value="XM_003860703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFD0"/>
    <dbReference type="GeneID" id="13386573"/>
    <dbReference type="KEGG" id="ldo:LDBPK_220010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220010.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0190"/>
    <dbReference type="OMA" id="SIHIQDN"/>
    <dbReference type="OrthoDB" id="276915at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP52541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="244" mass="28167" checksum="E86C1DC0E7CD3EF6" modified="2019-04-10" version="1">MDKSHVTELIQRWRVLKGNLTEKASELETVRKSLQELEGEHAKMTQQWDLEKETIRNTSSAIEAQVANKKDELQRIKQETQELHRKVEERRRRNEEHQLVLSKRKLIVDARVKEAEEKDAAARERLTTFQRSRDEARERLLAAVRKHEAAIPQDQAAHEDKVLQLKSRIAETLAAIDAEAKSWALEQAMKEWNEKSNARKHILDEVAAAEEGKDAWADLLREANSIHIQDNLTVLAELRAIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFL6</accession>
    <accession>E9BT08</accession>
    <name>A0A3Q8IFL6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_14345</name>
        <name evidence="3" type="ORF">LDBPK_354890</name>
        <name evidence="1" type="ORF">LdCL_350053900</name>
        <name evidence="2" type="ORF">LDHU3_35.6420</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000013">
        <property type="protein sequence ID" value="TPP47855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865066.1">
        <property type="nucleotide sequence ID" value="XM_003865018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFL6"/>
    <dbReference type="GeneID" id="13387944"/>
    <dbReference type="KEGG" id="ldo:LDBPK_354890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_354890.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350053900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.6420"/>
    <dbReference type="OMA" id="AYWFKPE"/>
    <dbReference type="OrthoDB" id="276884at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP47855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="389" mass="44114" checksum="D46AF3483B0917DE" modified="2019-04-10" version="1">MHNRVVFYKPLQRQPLSGRIGELMPLGTHPLLCFNPDTVRRMCSRYGVPVDDVVAALRDASGDVNLATELLEQRLDIEVGFGSYGLVCLESYAPETFCLVSYNLPTFASTQADEVLDAIHELTLSAAELPLDTPRDRLVDKFINHWTTEDDVPCADMLRSYNITVQNILLLPFGDYGVQGFHVLLPVKKETPNIGVAAAACCMDLRTGIHNRFRFHVERIADSVSEHVVQEMLHYNQGVHLLRQPYWFRPEYSVEEFIRFKESLLQPSASTFEMRYAFLFAPQYALPHYRNIVEMEKLKIAQHKYEKHYEDFTAPGKWLTSDNAQLQTVAAGGGGSNVPGGAMHNHTNDPASIRTAMETRTGPLRRTLAQSMQAHGDRVFSRFYRNNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFU7</accession>
    <name>A0A3Q8IFU7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_230017600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFU7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_272290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1430"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18623">
        <property type="entry name" value="GH32_ScrB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="396"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="527" mass="59857" checksum="5E920F80CADDC32E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG22</accession>
    <accession>E9BNJ6</accession>
    <name>A0A3Q8IG22_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC21_20025</name>
        <name evidence="14" type="ORF">LDBPK_320920</name>
        <name evidence="13" type="ORF">LdCL_320014800</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000009">
        <property type="protein sequence ID" value="TPP43606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863509.1">
        <property type="nucleotide sequence ID" value="XM_003863461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG22"/>
    <dbReference type="GeneID" id="13390322"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320920"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320920.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320014800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.1210"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000133">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="231"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ36824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP43606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="499" mass="56726" checksum="8E6C7F87908250CC" modified="2019-04-10" version="1">MEQALIEAAILKALSSAERVLSTDVADSIRADHQDIVGAGKSLEADNYIRSEMEQRMVLRLSNEAQQIMESGSPEYLVWCLLQDGRISQEDVAAKLGKEATGVALTNGIKSKMFKTIKENGKVFLERVPRSDNVVDAVRESLKQAAAAADEVDTKTLETLKKRKLAAMEAKKVFVYTKGAAYAPERAAKAVGDLTREMLVDGSWKNRQFKEYNFSAQGAEVGGGALHPLLKVRQEFREILMELGFQEMDTQHWAEVSFWNFDSLIIPQQHPARDLQDTFFLSKPETSKVNDLEYVARVKAQHEESFRTPWKLEEASRNVLRTHTTGSSAFVLKNIAKFAIRGPDGKLHFSPGRYYSIDRVFRNEEMDRTHLCEFHQVEGFVIDRDISLAKMMHTFDSFFRRIGVSQLRFKPAFNPYTEPSMEIFGFHTGLNKWIEVGNSGLFRPELLRPMGFEDGVTVMAWGLSLERPTMIKYGINNIHELFGHRVDIRFIKRAAIARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IG64</accession>
    <accession>E9BIX0</accession>
    <name>A0A3Q8IG64_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)/RNA_recognition_motif_(A.k.a._RRM_RBD_or_RNP_domain)_p utative/Pfam:PF00076/Pfam:PF14259/Pfam:PF13893</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_270360</name>
        <name evidence="4" type="ORF">LdCL_270008400</name>
        <name evidence="5" type="ORF">LDHU3_27.0440</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861893.1">
        <property type="nucleotide sequence ID" value="XM_003861845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IG64"/>
    <dbReference type="SMR" id="A0A3Q8IG64"/>
    <dbReference type="GeneID" id="13389154"/>
    <dbReference type="KEGG" id="ldo:LDBPK_270360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_270360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270008400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.0440"/>
    <dbReference type="OMA" id="KMHAFIP"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="378"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5431144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="495" mass="53433" checksum="5E89D49836F9131A" modified="2019-04-10" version="1">MMNVKQAKAWEDISLCRSVSTISSSASTAEATAGNDVSSFLFEDYRDDAFSTKSRCKHWLSVGHLGLTTTDAELKSLFYPYGADEAFTAWEGAIMTGFVGFDSPEMADLAAQKMHAFVPRGQSQALTVHAVTLEEVSQAHSKSPKSLLAALCSECPTQGISAMIRRSKSPVAVARDVAMEVARASPVILQRLLAALSDLSPQWFGFASFTEELLKSLLGLLLEAGELNAAQTINCGTVAGNLFQMKMTTGDPYYLAGRLLLKAGHRLGQLEGICALAHTCAMIPNCHMSRASFWAQVADIATKVTDPEASHALLGHLRRYTKTSAHVATTATSLLSSSVSSPSVFSTMPCAPATATQQQLVRQLVPLQYPRQDEMKRRTIYVSHLPGLLPQSMLLELLTTAGPVNKVRICAGAGYCTLFAFVEMRTLEGAQRAMCMNGLQLMGFAIRVQTARNAVQDVLEEDARFDANGALIQPCLFGVSQAPLSKCLSPAEWIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGM5</accession>
    <accession>E9BUT4</accession>
    <name>A0A3Q8IGM5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphorylated CTD interacting factor 1 WW domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Phosphorylated CTD interacting factor 1 WW domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_15160</name>
        <name evidence="4" type="ORF">LDBPK_365770</name>
        <name evidence="3" type="ORF">LdCL_360065100</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ39013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865690.1">
        <property type="nucleotide sequence ID" value="XM_003865642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGM5"/>
    <dbReference type="GeneID" id="13388576"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365770.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360065100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7670"/>
    <dbReference type="OMA" id="IEPHHAS"/>
    <dbReference type="OrthoDB" id="193787at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCIF1 WW" evidence="2">
        <location>
            <begin position="344"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PCIF1 WW" evidence="2">
        <location>
            <begin position="494"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ39013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="657" mass="70977" checksum="AFCF3CBD8362C43E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IHY2</accession>
    <name>A0A3Q8IHY2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC20_6825</name>
        <name evidence="4" type="ORF">CGC21_35725</name>
        <name evidence="1" type="ORF">LdCL_300024000</name>
        <name evidence="2" type="ORF">LDHU3_30.2580</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_360</strain>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IHY2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301870.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300024000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2580"/>
    <dbReference type="OrthoDB" id="269638at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP43331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="118" mass="13773" checksum="9730590269BDE336" modified="2019-04-10" version="1">MKKYIGRQLRPSQLAAELLPPDQMWCTVCHQAVERRRFREHAAMLGHRLGRKKMNKLKYVSLSMWERHRGASLDNESAHEGSIEQEFARYQADQRRREQVSVAAAWGPSRPPSRGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IIZ5</accession>
    <accession>E9BL39</accession>
    <name>A0A3Q8IIZ5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CGC20_24895</name>
        <name evidence="12" type="ORF">CGC21_28700</name>
        <name evidence="10" type="ORF">LDBPK_292420</name>
        <name evidence="8" type="ORF">LdCL_290030200</name>
        <name evidence="9" type="ORF">LDHU3_29.3610</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000010">
        <property type="protein sequence ID" value="TPP50666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862660.1">
        <property type="nucleotide sequence ID" value="XM_003862612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IIZ5"/>
    <dbReference type="SMR" id="A0A3Q8IIZ5"/>
    <dbReference type="GeneID" id="13385363"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290030200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3610"/>
    <dbReference type="OMA" id="FCDARED"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU80736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5431959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ35967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP50666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP52865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="267" mass="29037" checksum="4F2BA5C1B42DEC80" modified="2019-04-10" version="1">MFRYSHLIRCAAQPVVKACQVGPVVTLTINRPTQLNALNRAVSESLMENLEKYDKDPSCSAFIITGEGRAFVAGADIKSMKDRTFSEGVLSNDFQALTRIRTIGKPIIAAVNGFALGGGCELAMSCDIIVASEEAKFGQPEIKLATIPGLGGTQRLTRMIGKARAMEWVLLGNTYTAAEAERAGIVSRVVKHEELMPTAMFMAEKIASYSQIAVKLAKMAVNESQETLLAAGLAYESMVFNSTFSTHDRKEGMTAFVEKRAPQFQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJ24</accession>
    <name>A0A3Q8IJ24_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_360014300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJ24"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360930.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360014300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1230"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001279">
        <property type="entry name" value="ATP-dependent RNA helicase DEAH12 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF269">
        <property type="entry name" value="SPLICING FACTOR ATP-DEPENDENT RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="203"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="420"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="944" mass="103798" checksum="FF04BE078633C130" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IJB7</accession>
    <name>A0A3Q8IJB7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_360029000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IJB7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362330.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360029000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.3110"/>
    <dbReference type="OrthoDB" id="266608at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="643" mass="68605" checksum="7EB893B1D82F06AD" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ILB5</accession>
    <name>A0A3Q8ILB5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 4-phosphate 5-kinase alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_340037400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ILB5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_044320.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340037400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.4970"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000018">
        <property type="entry name" value="Phosphatidylinositol-4-phosphate-5-kinase-likep ro tein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU82652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="546" mass="61059" checksum="B6434AAE71EA8E1F" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IRK5</accession>
    <accession>E9BUL4</accession>
    <name>A0A3Q8IRK5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_14810</name>
        <name evidence="3" type="ORF">LDBPK_365060</name>
        <name evidence="2" type="ORF">LdCL_360057800</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865620.1">
        <property type="nucleotide sequence ID" value="XM_003865572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IRK5"/>
    <dbReference type="GeneID" id="13388506"/>
    <dbReference type="KEGG" id="ldo:LDBPK_365060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360057800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.6780"/>
    <dbReference type="OMA" id="FMLVGTQ"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP48612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="472" mass="51859" checksum="8F8510593C493D0F" modified="2019-04-10" version="1">MTSGYCSYASASGSGHERVTRILVVGEASVGKTLLIRRLCDHIFGDTSITSTDEVSAPESPYQSQSAVADDDLGPKWGPTVGIAVDALKRTTTVLDDTVTIPNVAMSTPYDTAAMTRYTAPPSNFHSGENGNYPSCSVYGTPCSTSGYGGSNSVLQYRGQGFVGSNTSFALPHLVASASPPRRQTVLQTVEFHELGGTHGYRDVARMLLRNIHYDGVMFVYHRRSLTSTLYLKEWYRWIRSVLSASPDIGSDYGAEANKPAKSSKTMPRFMLVGTQLPGDELPAAAAGLAKTTAETLHMACGAISDETLLDGNLEVKLRALQSPQTLTQRRGVRHALGKVLRRLAWPYHVWWCVSHPFFLLSKQYQEELGPRSRLGACGSRVVERFVWLLYQAEQALMYVMAVILFGPYQEAVVLGHSRLKQTLEEMLKDELCVSQAHVCRLDSNMSLQSSLDDVVAFFDILLRQDAPDEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ISN5</accession>
    <accession>E9BMV2</accession>
    <name>A0A3Q8ISN5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_11365</name>
        <name evidence="3" type="ORF">LDBPK_311780</name>
        <name evidence="2" type="ORF">LdCL_310025100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863269.1">
        <property type="nucleotide sequence ID" value="XM_003863221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ISN5"/>
    <dbReference type="GeneID" id="13389443"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310025100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.3070"/>
    <dbReference type="OMA" id="PFMAERA"/>
    <dbReference type="OrthoDB" id="273856at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP42588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="375" mass="40922" checksum="64CA64C9F7F7799B" modified="2019-04-10" version="1">MACAVPSPGTSQVVTCPSTLTSPVKIDQEWSITTSSATHATPIPQAPVATLCTLSKASATTTPVADGTHAFLQPSPVSAMSAIRRFLRRSSIMVPFMAERAAKEVVVLPPPIHRLYRQADETRRSLVRRADFLASCGENELAAENADACVSADREASAKVDRPRGDVFDFTWTRKEVNAMRMQQREYLRRQRGSPHAPVLVRMNELASNLLNDGDWEQMEKASPTVAAVAAPAVHANVANIVAGLCTRAIPQAEYIRSVFNYRMSVLQKRINAVPTGVVVPAVVQATMTLDELSESHSGESIPKYKKDKATSKKALSPTTAPTVTFPHPGVPFTYQDLAQDPLLLTAEQRADRRAALLHRRTLSEEVYGQPVPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IT00</accession>
    <name>A0A3Q8IT00_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Utp14 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_320006400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IT00"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320006400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0230"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="606"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="998" mass="110671" checksum="FCF14AE2CA2A7BD6" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IUI3</accession>
    <name>A0A3Q8IUI3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_340018500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IUI3"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1980"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20104" checksum="BBD4B86C93AA08AD" modified="2019-04-10" version="1">MEIADRPLSEIIKEQKIDKELRRRHRGSQSGGSNDKKSVSRQGNSSQRQRHNNNKSASGSRSRGSGDRSGGNKPESGRRRFRTDGGRRRAGNTVSAGSGSFGASRRRLADREGRRRRGALGGDNGNGGFGRGRDRDNNDRRGVKSAPRRRRISGAERNERNRNRDRRSALSRSRFDRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IUL7</accession>
    <name>A0A3Q8IUL7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_340025800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IUL7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341820.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340025800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.3120"/>
    <dbReference type="OrthoDB" id="2126250at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32522">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32522:SF3">
        <property type="entry name" value="ABC3 TRANSPORTER PERMEASE PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU82536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1128" mass="124159" checksum="2E813EE9A03E1ADB" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H526</accession>
    <name>A0A3S5H526_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-finger of acetyl-transferase ESCO, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_030006700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H526"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030170.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0170"/>
    <dbReference type="OrthoDB" id="267539at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="2">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="727" mass="75747" checksum="A38D7A08F055B662" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H632</accession>
    <name>A0A3S5H632_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein (LRRP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_080006700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H632"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_080180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080006700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.0210"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF61">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU76319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58581" checksum="D346234334966C73" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6F4</accession>
    <accession>E9BA69</accession>
    <name>A0A3S5H6F4_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_36000</name>
        <name evidence="11" type="ORF">CGC21_23800</name>
        <name evidence="10" type="ORF">LDBPK_100210</name>
        <name evidence="8" type="ORF">LdCL_100007400</name>
        <name evidence="9" type="ORF">LDHU3_10.0340</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029509">
        <property type="protein sequence ID" value="AYU76628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812630">
        <property type="protein sequence ID" value="CAC5427975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799597">
        <property type="protein sequence ID" value="CBZ32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000036">
        <property type="protein sequence ID" value="TPP46653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000045">
        <property type="protein sequence ID" value="TPP51581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858860.1">
        <property type="nucleotide sequence ID" value="XM_003858812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6F4"/>
    <dbReference type="SMR" id="A0A3S5H6F4"/>
    <dbReference type="GeneID" id="13392200"/>
    <dbReference type="KEGG" id="ldo:LDBPK_100210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_100210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_100007400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_10.0340"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000004">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="302"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU76628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5427975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP46653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP51581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="473" mass="52612" checksum="3FF9A1DC6D59F85E" modified="2019-04-10" version="1">MSRTLYTLYEAPTGYAIFKVRTTEEIGAEDVALQKELQSFSTFSPWVKLVSFAPFESPENALEDAVCISENLISTFLNNFLTAAFAKKVAKNEANWELGVQDPKLGSAIHDELNIPVLCNETVAEISRCIRLHAEKLLPEHNEGDVPRAQCGLGHAFSRNKVKFNVHRSDNMIIQASALMEHMDKGVNLLGMRVKEWYGWHFPELAKEVPEPLKYANVALLIGNRNSLEAVPEEDVKAQLGDILEGDEALAARVYEKAVTSMGGDMAEVDWDCIRTFAKRVASLGQYRVALAQYLVDKMMLVAPNLTQLMGQTIGAKLISKAGSLTNLAKSPASTIQILGAEKALFRALKKKKGNTPKYGLIFHSSFIQRASKENRGKISRYLANKAALACRIDCFMDAPPTVFGEKLREQVEARLNFFDTGNKPPSNKAAMAEALEQYQRILRKRDRKQADEDAEETPKKKSRKVVAASESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6K0</accession>
    <accession>E9BAX1</accession>
    <name>A0A3S5H6K0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LDBPK_111350</name>
        <name evidence="5" type="ORF">LdCL_110019400</name>
        <name evidence="6" type="ORF">LDHU3_11.1670</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859108.1">
        <property type="nucleotide sequence ID" value="XM_003859060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H6K0"/>
    <dbReference type="GeneID" id="13389808"/>
    <dbReference type="KEGG" id="ldo:LDBPK_111350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_111350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110019400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.1670"/>
    <dbReference type="OMA" id="KNWPNTG"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU76905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC5428236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CBZ32396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="436" mass="50139" checksum="6C1FB6C0E4D7A09B" modified="2019-04-10" version="1">MYDSRSSGVHDVAPRDEVDFMYEGPHQVLPGAHPLPLFHPNNSVTRPPVSPYLPSPQRPHPYFTHELPELPHFQTTRPIVYTVGTMKQRIVAPVFDLSNNVTHTRELDPFIFGFYPETEEMAKNLSYWLVRCQNFSSKWDYENREIWRKAKKNWPNTGMGMARVGDRKNHAHPWGAQSKPVKPWNMLMPTMDVKTWSKSNRMLVTLKMLQGKLQIVERLTLPEPTQEAYLQLCRTMGWDVRHTGGGALFMDGGSRLTPSSEYDRAFFFGSFFNGRNKLVRPTLLCDEPYDYNRTSSKARTKGPKGQKNPIPINRFNAYDALTHDTLIITEGALMQLEDEMYTHKLAILPPHIRAQLPERGFLDSEVLGDVPPALQTVQMEAAARTEEAERAMYAPYYDNPYHPWKDEGEASYAVDAVEGTVQRYIKSRKTSWMMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H6L0</accession>
    <name>A0A3S5H6L0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fusaric acid resistance protein-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_120011100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029511">
        <property type="protein sequence ID" value="AYU76971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_120540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_120011100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_12.0860"/>
    <dbReference type="OrthoDB" id="265582at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509:SF9">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="764"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1282"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1450"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1522"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1290"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1523"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1546"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1613"/>
            <end position="1627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU76971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1917" mass="203110" checksum="C0AB4B211B209C29" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H707</accession>
    <name>A0A3S5H707_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170012250</name>
        <name evidence="3" type="ORF">LdCL_170012500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H707"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170012250"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1270"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU77830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16350" checksum="F26D2CC77B8CE23E" modified="2019-04-10" version="1">MRSRSTLEPPTLPCHRPPVAWREAAVDTRRRGTAPTRASQHGLCLEPSPPTRLAVPPHSRSPFVPVAAWCISRGGAGSLHRWAARAGRDVLESRWRLVDRMDGAGVLAVSGRSDATPSRVWPSASVAMRRPDFATSQALGPVTAGSGSGTWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H721</accession>
    <name>A0A3S5H721_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily protein (MFS), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_180005300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H721"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180005300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0050"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU77930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="538" mass="57679" checksum="ED43EF8FFF5EE4B8" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H784</accession>
    <accession>E9BEK1</accession>
    <name>A0A3S5H784_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin/FtsZ family, GTPase domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Zeta tubulin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_29555</name>
        <name evidence="8" type="ORF">LDBPK_200540</name>
        <name evidence="7" type="ORF">LdCL_200010100</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029519">
        <property type="protein sequence ID" value="AYU78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799607">
        <property type="protein sequence ID" value="CBZ33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000023">
        <property type="protein sequence ID" value="TPP49945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860394.1">
        <property type="nucleotide sequence ID" value="XM_003860346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H784"/>
    <dbReference type="GeneID" id="13386181"/>
    <dbReference type="KEGG" id="ldo:LDBPK_200540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_200540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_200010100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_20.0640"/>
    <dbReference type="OMA" id="RLYFTEP"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004058">
        <property type="entry name" value="Zeta_tubulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01520">
        <property type="entry name" value="ZETATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP49945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="605" mass="65834" checksum="692E30E5F86DCA53" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7F3</accession>
    <accession>E9BI00</accession>
    <name>A0A3S5H7F3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_9200</name>
        <name evidence="2" type="ORF">LDBPK_252460</name>
        <name evidence="1" type="ORF">LdCL_250030400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861576.1">
        <property type="nucleotide sequence ID" value="XM_003861528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7F3"/>
    <dbReference type="GeneID" id="13388822"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250030400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2940"/>
    <dbReference type="OMA" id="YSCHAKW"/>
    <dbReference type="OrthoDB" id="242756at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="364" mass="39709" checksum="29A71330BC0DB565" modified="2019-04-10" version="1">MTSNRDAKRHGFRYGAPAAVVDPLLSFLFDLRRMEDTVLSTLDHIGVRRRDLPRPFGGGSSASPPEVPATADDDAAVFSEAPSLRMPASDPIDAYAYEIAANSSDAHDVSVVGVIHQLLSWLDSNSSSSQLSSPPSQQLLTIFAAAVGAGADVFLRDAATLEDTHVERTFKRPKPDKSVASPTFDGETLACGDDSTARLVGTLTAGDIHAAVQEWRGYERLLKSSVAEMKTTLAAVTAARPNSSYSCHAKWIERTRSDGKSTFVVPASAVLKRNYEELISLNDALATCQAAVHAAYVALEDNLDVLLEEAQTVDRQERLFQHHVSVARRECAALHELRRRIKQVRKTLERCAHGQRGRPKVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H7V2</accession>
    <name>A0A3S5H7V2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_330034400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H7V2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330034400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3870"/>
    <dbReference type="OrthoDB" id="273455at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1052" mass="109754" checksum="492037BD96B5F606" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H816</accession>
    <accession>E9BTE5</accession>
    <name>A0A3S5H816_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_12755</name>
        <name evidence="4" type="ORF">LDBPK_360860</name>
        <name evidence="3" type="ORF">LdCL_360013600</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865202.1">
        <property type="nucleotide sequence ID" value="XM_003865154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H816"/>
    <dbReference type="GeneID" id="13388088"/>
    <dbReference type="KEGG" id="ldo:LDBPK_360860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_360860.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.1130"/>
    <dbReference type="OMA" id="GYMVIRE"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU83430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP48201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="557" mass="61541" checksum="DD5D346D638EB706" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S5H823</accession>
    <accession>E9BTR9</accession>
    <name>A0A3S5H823_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_362100</name>
        <name evidence="1" type="ORF">LdCL_360026500</name>
        <name evidence="2" type="ORF">LDHU3_36.2720</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865325.1">
        <property type="nucleotide sequence ID" value="XM_003865277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S5H823"/>
    <dbReference type="SMR" id="A0A3S5H823"/>
    <dbReference type="GeneID" id="13388211"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362100.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360026500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2720"/>
    <dbReference type="OMA" id="QWRINHA"/>
    <dbReference type="OrthoDB" id="264067at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU83555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5434780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11794" checksum="4404AEA1EC996A85" modified="2019-04-10" version="1">MTESAEALQRRINYAIENQMAPPETNYISELLAASLALDNSNEQLRLLDYRWQTYLDKQYVQSQHLDEFLEGLVQHLLKKKPDRPLEELLLYLECERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNM1</accession>
    <name>A0A3S7WNM1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_020010400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_020490.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020010400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_02.0610"/>
    <dbReference type="OrthoDB" id="267783at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1721"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1582"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1600"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1673"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1729"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1744"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1813"/>
            <end position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU75654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2114" mass="218498" checksum="462AB1885A1C6D15" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WNQ2</accession>
    <name>A0A3S7WNQ2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_040009600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029503">
        <property type="protein sequence ID" value="AYU75820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WNQ2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_040410.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_040009600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_04.0540"/>
    <dbReference type="OrthoDB" id="271173at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="359"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU75820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="672" mass="68894" checksum="E9FB4161D0EF1113" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WPM6</accession>
    <accession>E9B8Y1</accession>
    <name>A0A3S7WPM6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_19800</name>
        <name evidence="7" type="ORF">CGC21_24005</name>
        <name evidence="5" type="ORF">LDBPK_061210</name>
        <name evidence="3" type="ORF">LdCL_060017200</name>
        <name evidence="4" type="ORF">LDHU3_06.1360</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029505">
        <property type="protein sequence ID" value="AYU76151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812626">
        <property type="protein sequence ID" value="CAC5427502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799593">
        <property type="protein sequence ID" value="CBZ31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000054">
        <property type="protein sequence ID" value="TPP49718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000039">
        <property type="protein sequence ID" value="TPP54794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858427.1">
        <property type="nucleotide sequence ID" value="XM_003858379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WPM6"/>
    <dbReference type="SMR" id="A0A3S7WPM6"/>
    <dbReference type="GeneID" id="13391766"/>
    <dbReference type="KEGG" id="ldo:LDBPK_061210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_061210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_060017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_06.1360"/>
    <dbReference type="OMA" id="SFLMTVH"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000020">
        <property type="entry name" value="Nuclear transport factor 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5427502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP49718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP54794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="135" mass="16097" checksum="AFA8047144071FFF" modified="2019-05-08" version="1">MEQGAFNDVAKKALEFRNRYYKMLDDPQDRLNVAGLYAPDVPMVCEWNGHPLSTVDDVRNYISALPKTSHQIDMVDAQPLPDNQDGDSFLLTVHGIVTYNDEHRREFYQRMVIRRFEQRYYILNDYYRWLSERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQD7</accession>
    <name>A0A3S7WQD7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_080014000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029507">
        <property type="protein sequence ID" value="AYU76392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQD7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_080014000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_08.1210"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12506" checksum="AD4A0417563A56F0" modified="2019-05-08" version="1">MERCETVKTFSPTPPSVQALGASLAEVYTASPLAANTPVHANFQGARYICDETVVGMSLIQSVYGKRLLCAMGGCGRSAKVCDPIGCIVARWLPGKALSPDFALAEKLFRRMTAMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WQN6</accession>
    <accession>E9B9W1</accession>
    <name>A0A3S7WQN6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_36970</name>
        <name evidence="2" type="ORF">LDBPK_090740</name>
        <name evidence="1" type="ORF">LdCL_090012500</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029508">
        <property type="protein sequence ID" value="AYU76514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799596">
        <property type="protein sequence ID" value="CBZ32034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000042">
        <property type="protein sequence ID" value="TPP41709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858754.1">
        <property type="nucleotide sequence ID" value="XM_003858706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WQN6"/>
    <dbReference type="GeneID" id="13392050"/>
    <dbReference type="KEGG" id="ldo:LDBPK_090740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_090740.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_090012500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_09.0880"/>
    <dbReference type="OMA" id="PHWIRES"/>
    <dbReference type="OrthoDB" id="239229at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU76514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ32034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP41709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34125" checksum="F4EB3BF39F55C369" modified="2019-05-08" version="1">MSSKLINAVCTMATRECVAELALFHRALRTLHPTLPLYLGCSSEVRDAAEAATDATSQLRALYDDAHVRWVLCLDQYGPVISRAEMERQRGVWYPARHTDFMMEKANLMELALMTAEPSTPTVAFLDCDIILLRELPCVPAAAAVALSPHWIRESDEAIFGAFNGGYVVASTPEVLWEWRQATQTSRYFDQASLEHVAAVFERRAQLHRLPPQHNYGFWRLLQSRCGSVAEEAKRFSIAPAPSPGSEQQPAPMAVHYDGAPLCSVHTHFLMPDPPRDVRLFNAVLKRWLGRCAATNPVCAAVLAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WRI8</accession>
    <accession>E9BAK1</accession>
    <name>A0A3S7WRI8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NGG1 interacting factor 3-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NGG1_interacting_factor_3-like_protein/GeneDB:Lmj F.11.0130</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NIF3 (NGG1p interacting factor 3) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_30645</name>
        <name evidence="7" type="ORF">CGC21_1140</name>
        <name evidence="5" type="ORF">LDBPK_110130</name>
        <name evidence="3" type="ORF">LdCL_110006200</name>
        <name evidence="4" type="ORF">LDHU3_11.0150</name>
    </gene>
    <organism evidence="3 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 9" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="4" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029510">
        <property type="protein sequence ID" value="AYU76782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812631">
        <property type="protein sequence ID" value="CAC5428115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799598">
        <property type="protein sequence ID" value="CBZ32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000048">
        <property type="protein sequence ID" value="TPP39800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000035">
        <property type="protein sequence ID" value="TPP53076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003858991.1">
        <property type="nucleotide sequence ID" value="XM_003858943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WRI8"/>
    <dbReference type="SMR" id="A0A3S7WRI8"/>
    <dbReference type="GeneID" id="13389499"/>
    <dbReference type="KEGG" id="ldo:LDBPK_110130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_110130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_110006200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_11.0150"/>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC5428115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP39800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP53076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="279" mass="29932" checksum="8D96A0019127198A" modified="2019-05-08" version="1">MALLQRVVQVMQEVAPLSLADHSWDNVGVLLESPAPNKSNAIMLTIDLTPEVMEECLEKNVEVILAYHPPLFRPVKRLTLQDPKQRIILQAASAGMSIYAPHTSLDAAEGGINDWLASLVAGDGAYTASPIQPTSSYAPNAAEATKATGMGRLVKLKEEVEFCSMVGSLKQQLGLATVRVALPDSWEPSHKVSSVALCAGSGTSVFRLLRLPVHVLLSGEMSHHDVLAATAAGQAVILCEHTNTERGFLKAVLQRTLQAKLEGTTVLVSDKDRDPLAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WSP8</accession>
    <accession>E9BBL0</accession>
    <name>A0A3S7WSP8_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Squalene monooxygenase</fullName>
            <ecNumber evidence="13">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC21_33685</name>
        <name evidence="16" type="ORF">LDBPK_131360</name>
        <name evidence="15" type="ORF">LdCL_130020900</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="20" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="13"/>
    <dbReference type="EMBL" id="CP029512">
        <property type="protein sequence ID" value="AYU77233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799600">
        <property type="protein sequence ID" value="CBZ32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000031">
        <property type="protein sequence ID" value="TPP45246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859347.1">
        <property type="nucleotide sequence ID" value="XM_003859299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WSP8"/>
    <dbReference type="GeneID" id="13390774"/>
    <dbReference type="KEGG" id="ldo:LDBPK_131360"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_131360.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_130020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_13.1870"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 13 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Squalene epoxidase" evidence="14">
        <location>
            <begin position="210"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYU77233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP45246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="569" mass="63513" checksum="247A8215342D6945" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT68</accession>
    <name>A0A3S7WT68_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_140019700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT68"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140019700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1720"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001449">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="450"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="806"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="849"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1071"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1097" mass="113777" checksum="047E80BC8B1DE38F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WT74</accession>
    <name>A0A3S7WT74_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_140019800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WT74"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141390.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1740"/>
    <dbReference type="OrthoDB" id="252229at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="357" mass="38172" checksum="65A4A9957279E2A1" modified="2019-05-08" version="1">MYNPALPNHYRDVVFAAYVRRRQREEAAAAQQQRQPNALASALSASSLAAPSMASVNAPLLGLSAEELHQHRIKESAALGIQRAVMMEKEALEVEHKQRRLEGRDARSRISSRLDKLKALAAKSKAATGVSASVDAGGAVLQPDDPSSPTSSPFDAEAAPSAPLMFQRSSLAAGGYVMTAADPSLPGMLLRTNTRSAVQGKPSSTLLLRFLHDSPVLGWNKAAIAEASTFSSAESSLCVPVLAQVQQLCCRFGFVRSMAARVYAEDVVTAALARARSQTSVETQVPSAEEVRREQLRVWVRFDSVTEAFKAAESLAKEVPPATPAGLPVFAVAFYPTGLYDSDALELREEDLLAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUL5</accession>
    <name>A0A3S7WUL5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase (GlcNAc), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_170017200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029516">
        <property type="protein sequence ID" value="AYU77874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WUL5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_171120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_170017200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_17.1560"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE (GLCNAC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="638" mass="71822" checksum="5130CE0363D07CA7" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WUZ6</accession>
    <name>A0A3S7WUZ6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_180013600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180850.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180013600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1100"/>
    <dbReference type="OrthoDB" id="273711at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1543"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1746"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2207"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2487"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2559"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2713"/>
            <end position="2732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2803"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1749"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2504"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2721"/>
            <end position="2731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2810"/>
            <end position="2823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="2877" mass="303669" checksum="0B6ECA0AA289473E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WV04</accession>
    <accession>E9BDU3</accession>
    <name>A0A3S7WV04_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AN1-like Zinc finger containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">AN1-like_Zinc_finger_containing_protein_putative/ Pfam:PF01428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_181130</name>
        <name evidence="6" type="ORF">LdCL_180016500</name>
        <name evidence="7" type="ORF">LDHU3_18.1430</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812638">
        <property type="protein sequence ID" value="CAC5429329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860126.1">
        <property type="nucleotide sequence ID" value="XM_003860078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WV04"/>
    <dbReference type="SMR" id="A0A3S7WV04"/>
    <dbReference type="GeneID" id="13393440"/>
    <dbReference type="KEGG" id="ldo:LDBPK_181130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181130.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180016500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1430"/>
    <dbReference type="OMA" id="CHKRFCS"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5429329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="356" mass="38541" checksum="32745BDAFBAE4C2D" modified="2019-05-08" version="1">MQVGVYDRDDQMCQYEGCTEIDLLPARCSNCDKRFCTHHLSHNAHHCPAVTDVRVGTCPICYRVVPLEYPRQRVDEAVSRHIDRGCRDVPQGSLFYGGAVAKGRPGQASGRRLGGPIRPCSIQGCHEASETRVKCDQCGQTFCLQHRGPLQHHCRAAAATRSAVASSPSDRDAGMLVSLPGDKAASVACLLTHPANTPEKAVGKATELPSDMVTCLVCFLIPTSVFKKDCNAGCEEFEPVPSFFMFMPKNTALGRLLDTAVDRAAMSSPAVRTGKPWNLFAVTLPIHAEAEAAYYSPLPLSTVVRKSVVGMAERTIVFLSPLQALPESVIKVVKDLDRKGSWPSPSLSSSQGCQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWD2</accession>
    <accession>E9BF39</accession>
    <name>A0A3S7WWD2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_33970</name>
        <name evidence="4" type="ORF">LDBPK_210540</name>
        <name evidence="3" type="ORF">LdCL_210010200</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860571.1">
        <property type="nucleotide sequence ID" value="XM_003860523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWD2"/>
    <dbReference type="GeneID" id="13386363"/>
    <dbReference type="KEGG" id="ldo:LDBPK_210540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210010200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0580"/>
    <dbReference type="OMA" id="CAYQRYF"/>
    <dbReference type="OrthoDB" id="263797at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="496" mass="52942" checksum="F1E207AFC3E28D5F" modified="2019-05-08" version="1">MDQLAVDLSALRELVLQHQHQQRLANDTHVGVDAVAVPSALSASTSAATVTTTADKLRQLQRELGALTEQLHAEKAASAQRLLQQRCDAASLQELLDQAARADEKVADLTSQLTEWKRRCQAVEEAHAGCTGQYESVREQVECVQRHVAETQAQHAVLTARATEAQRLVSKLADEKAQLQGTLRSRDAALLRLSGVELDRDEARARVQAFEAQHAEWVAEVCAYQRYFDSAREEYVRGLRHVAAVRQEHEALREALTQSEARCVHWEKLFTDLSAGACAGFAATPADASTEEAAADISGASSAVIAVGVAEDGSPSSGGCCDASDCFDHPTSPFDAAFVPLLEAKVADLALRLCDAQARADAAERTAEDLSRLSLADSTLLIHLKSLVCALRPQVDGVADHNAQLQARLLAAESFTDALMQHVVRLGEAFADEASQRCWLTAASSASAIGGGGGVDVLSGGSGGRGSETTLPPATPPSALTQSRRHRLRTRVLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWM2</accession>
    <accession>E9BFE0</accession>
    <name>A0A3S7WWM2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ring finger domain family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ring finger domain/RING-H2 zinc finger/Zinc finger, C3HC4 type (RING finger) containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_34405</name>
        <name evidence="8" type="ORF">LDBPK_211540</name>
        <name evidence="7" type="ORF">LdCL_210020900</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ33966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860671.1">
        <property type="nucleotide sequence ID" value="XM_003860623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWM2"/>
    <dbReference type="GeneID" id="13386519"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211540"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211540.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210020900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1820"/>
    <dbReference type="OMA" id="WITLGHY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU78616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP49373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="276" mass="28389" checksum="4FB669DBB217E4D1" modified="2019-05-08" version="1">MFPSGFPSSAAGSGNNTAGATAPHMHVHTVVINVGDTDGTAVGGNAGVADVFSGVPATVSAVMTAAMDLSDLPGLIDLLSDTTPASTAAREWHAESCPPFSPEEVISTFDVVQPPLSSPVTATASTSRRETDGADTAASPSPPAPEAKECAICLEPLFRTSVVRSAPESGESMPNSAPPLSELSTADREKPATASQSPPLQSQAPSSPPSVPPPDAAASSDATRPLAHDDTAEAAKDAKTVREVYCGHRFHESCILRWITLGHYSCPLCRSPFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWV0</accession>
    <name>A0A3S7WWV0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LdCL_210022500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWV0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210022500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1980"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="3">
        <location>
            <begin position="126"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="479" mass="53407" checksum="57E6379951FFFB10" modified="2019-05-08" version="1">MFHISRAVRCNALATAIAGRTSLSDAIRQVQKVWNLDFKDGPVTTSTLTFNDEPDPAAPIFHVLDLQGGVFVEEKADSGAAAATPSTVNEAGKTELQSAELGQVFRYHAKDETSVITREVAERMMSAMLTHNTIDKIMLEAQRQGRISFYMTMFGEEAAVIGVAAGLASNDELFAQYREAGILTYRGYTIPEFIAQCMGNCECDLKGRQMPIHYGSKRLNAQMVSSPLATQIPHGAGAGYAFRLENQALERRLPTGTLLSTIPEARICATFFGEGAASEGDFHAGLNFASTVGSHTLFFVRNNGYAISTPTHSQYMGDGILSRAVGYGMPAARVDGLDALAVYHTVRKAREMILNNHRPVLVEALTYRLSHHSTSDDSTAYRSRDEIEHFAETFSPIERFERFMAERGWWTPEQSTEVVERTRREVLSELRRQEKLPAWPVSTLCDDVFEHLTPELERQRAQLVEHYQAHRSIYDQEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WWW7</accession>
    <accession>E9BFI1</accession>
    <name>A0A3S7WWW7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_21990</name>
        <name evidence="5" type="ORF">CGC21_34590</name>
        <name evidence="4" type="ORF">LDBPK_211950</name>
        <name evidence="2" type="ORF">LdCL_210025200</name>
        <name evidence="3" type="ORF">LDHU3_21.2340</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="9" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812641">
        <property type="protein sequence ID" value="CAC5429929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799608">
        <property type="protein sequence ID" value="CBZ34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000021">
        <property type="protein sequence ID" value="TPP49410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000035">
        <property type="protein sequence ID" value="TPP54605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860712.1">
        <property type="nucleotide sequence ID" value="XM_003860664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WWW7"/>
    <dbReference type="GeneID" id="13386543"/>
    <dbReference type="KEGG" id="ldo:LDBPK_211950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211950.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210025200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.2340"/>
    <dbReference type="OMA" id="DEHEVEC"/>
    <dbReference type="OrthoDB" id="261305at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5429929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP49410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP54605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="241" mass="27279" checksum="6FEB4028D57765B0" modified="2019-05-08" version="1">MKIFSTLGRPGTLATTKPKKGEVVLASPEATVSKYKGAIKQHKKALKELHACTERFTRALAAVAASLQFLTSDTHIPVMVQSSGALASGIEEVQDGVLLQDLMEELDYSLSTRFKQIAEDQRELKESRERKSKAEKTLMLLRSQCDKLQLKKDVDAKMQALYLTKTQKRDEHEVECTRLRAEFEDAFHDFTTRFGILVYEDMKGLMEHLHRVLSALSYQVRKCKDNILAHPITPKPIAEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WX34</accession>
    <name>A0A3S7WX34_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_220010500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029521">
        <property type="protein sequence ID" value="AYU78748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WX34"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_220420.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_220010500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_22.0730"/>
    <dbReference type="OrthoDB" id="278676at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="891" mass="96858" checksum="332EECA054DC9FE8" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WXJ3</accession>
    <name>A0A3S7WXJ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_230010600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230520.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230010600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.0730"/>
    <dbReference type="OrthoDB" id="273634at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1382"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="661"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU78929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1417" mass="155477" checksum="80F5A7EAD97D7DFA" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WY56</accession>
    <name>A0A3S7WY56_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside 2-deoxyribosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_230027000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU79082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WY56"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231980.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230027000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.2590"/>
    <dbReference type="OrthoDB" id="269441at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070694">
        <property type="term" value="F:5-hydroxymethyl-dUMP N-hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051239">
        <property type="entry name" value="2'-dNMP_N-hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15364">
        <property type="entry name" value="2'-DEOXYNUCLEOSIDE 5'-PHOSPHATE N-HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15364:SF0">
        <property type="entry name" value="2'-DEOXYNUCLEOSIDE 5'-PHOSPHATE N-HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16951" checksum="EF63CD4DAE0EB7E2" modified="2019-05-08" version="1">MATPKTIYIAGPAVFHPDNGEAYYNNVRALMKEKRVVPLIPVDNIATGALSIRNKNIDMIRACDAVIADLSPFRSKEPDCGTAFELGYAAALGKLLLTFSTDTRPMVEKYGGEMADGLSVENFGLPFNLMLHDGTDVFDSFEAAFAHFVEHHLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WYG9</accession>
    <accession>E9BH30</accession>
    <name>A0A3S7WYG9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RING-H2 zinc finger family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Ring-box protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Ring-box_protein_putative/GeneDB:LmjF.24.1610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CGC20_12205</name>
        <name evidence="17" type="ORF">CGC21_16435</name>
        <name evidence="15" type="ORF">LDBPK_241680</name>
        <name evidence="13" type="ORF">LdCL_240021900</name>
        <name evidence="14" type="ORF">LDHU3_24.2050</name>
    </gene>
    <organism evidence="13 19">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 19" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="21" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
            <strain evidence="17">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="14" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029523">
        <property type="protein sequence ID" value="AYU79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812644">
        <property type="protein sequence ID" value="CAC5430497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799611">
        <property type="protein sequence ID" value="CBZ34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000021">
        <property type="protein sequence ID" value="TPP44963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000020">
        <property type="protein sequence ID" value="TPP52292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861258.1">
        <property type="nucleotide sequence ID" value="XM_003861210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WYG9"/>
    <dbReference type="SMR" id="A0A3S7WYG9"/>
    <dbReference type="GeneID" id="13391180"/>
    <dbReference type="KEGG" id="ldo:LDBPK_241680"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_241680.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_240021900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_24.2050"/>
    <dbReference type="OMA" id="AECGITW"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000846">
        <property type="entry name" value="Ring-box protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC5430497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CBZ34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP52292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="119" mass="13108" checksum="08578A30425082FD" modified="2019-05-08" version="1">MSAEPTSTTAAASNAAPPQTLMPGGRQLFTVEEFYPVYFSAWERETGLCSICCNQVEGPCVVCQSNAEATSAECSITWGECGHAFHTHCIEKWLKTRPVCPLDNKEWKDRSDWNTSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZ14</accession>
    <name>A0A3S7WZ14_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Protein phosphatase, putative</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Protein_phosphatase_putative/GeneDB:LmjF.25.0750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CGC20_26850</name>
        <name evidence="6" type="ORF">LdCL_250013100</name>
        <name evidence="7" type="ORF">LDHU3_25.0980</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZ14"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250780.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250013100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0980"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000073">
        <property type="entry name" value="Putative phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC5430653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP48951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="406" mass="45111" checksum="7234EF47ECDED458" modified="2019-05-08" version="1">MGIPLPKPVMTQLQERYGNAIFRCGSNCVNGYRETMEDAHLTYLTDSWGFFGVFDGHVNDQCSQYLERAWRSAIEKESIPMTDERMKELALRIDQEWMDSGREGGSTGTFFVALKEGNKVHLQVGNVGDSRVVACIDGVCVPLTEDHKPNNEGERQRIENCAGRVENNRVDGSLAVSRAFGDREYKLGSGSQLEQKVIALADVQHKDFTFDSNDFVLLCCDGVFEGNFPNEEVVAYVKQQLETCNDLAEVAGRVCEEAIERGSRDNISCMIVQFKDGSDYAAEPHTTVVPGPFSAPRNSGFRKAYESMADKGNTTVGALLEKRYDTLKAAEALTPEETEELSQFENGPEAKLTGAERQKWFSNYFQKLCEAASNGPSDQMERLQSLQQQAGIPLSILLSLMGEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZF7</accession>
    <accession>E9BI05</accession>
    <name>A0A3S7WZF7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_26090</name>
        <name evidence="14" type="ORF">CGC21_9225</name>
        <name evidence="13" type="ORF">LDBPK_252510</name>
        <name evidence="11" type="ORF">LdCL_250031000</name>
        <name evidence="12" type="ORF">LDHU3_25.3020</name>
    </gene>
    <organism evidence="11 17">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11 17" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="14" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="14">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861581.1">
        <property type="nucleotide sequence ID" value="XM_003861533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZF7"/>
    <dbReference type="GeneID" id="13388827"/>
    <dbReference type="KEGG" id="ldo:LDBPK_252510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252510.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250031000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.3020"/>
    <dbReference type="OMA" id="WAHVLFN"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5430829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CBZ34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP40847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="250" mass="28830" checksum="C23D23697DD84843" modified="2019-05-08" version="1">MPVCIECGHGVPRIIKPDTETVERCGECGHICDICYEFGDVQIWIDVVLLRHRAWAHVLFNQTDYYTKLVIFVLCCVVEAVVVHSLTVLKAIPFFTDDLENSSLYTPERQVRSLQLVRIIQSSFLPLMNYPSAIPHLFIFTFTENALVASIATWLGRFFYRSYGHREHLWFVEAALASYAKLSYVLFLIWAIPPSMLPMVDFVYVLWLGCAFTVLGFDRHWMYPVAAVLICVCARALFRYLTKWSPQVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7WZQ1</accession>
    <name>A0A3S7WZQ1_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260014600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7WZQ1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_260900.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260014600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.1150"/>
    <dbReference type="OrthoDB" id="242938at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU79691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="77509" checksum="51A0DD8AE571C405" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X0N9</accession>
    <accession>E9BJ47</accession>
    <name>A0A3S7X0N9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_32745</name>
        <name evidence="16" type="ORF">CGC21_30835</name>
        <name evidence="14" type="ORF">LDBPK_271150</name>
        <name evidence="12" type="ORF">LdCL_270018000</name>
        <name evidence="13" type="ORF">LDHU3_27.1810</name>
    </gene>
    <organism evidence="12 18">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="12 18" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">LdCL</strain>
        </source>
    </reference>
    <reference evidence="20" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
            <strain evidence="16">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="13" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029526">
        <property type="protein sequence ID" value="AYU80009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812647">
        <property type="protein sequence ID" value="CAC5431238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799614">
        <property type="protein sequence ID" value="CBZ35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000016">
        <property type="protein sequence ID" value="TPP46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000016">
        <property type="protein sequence ID" value="TPP47525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861968.1">
        <property type="nucleotide sequence ID" value="XM_003861920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X0N9"/>
    <dbReference type="SMR" id="A0A3S7X0N9"/>
    <dbReference type="GeneID" id="13389230"/>
    <dbReference type="KEGG" id="ldo:LDBPK_271150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_271150.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_270018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_27.1810"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC5431238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TPP47525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="529" mass="57732" checksum="AA618C029D806C35" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1S9</accession>
    <accession>E9BJU4</accession>
    <name>A0A3S7X1S9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CEP76 C2 domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">CEP76_C2_domain_containing_protein_putative/Pfam: PF15627</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_282230</name>
        <name evidence="4" type="ORF">LdCL_280027400</name>
        <name evidence="5" type="ORF">LDHU3_28.3020</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862322.1">
        <property type="nucleotide sequence ID" value="XM_003862274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X1S9"/>
    <dbReference type="GeneID" id="13387058"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282230.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280027400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3020"/>
    <dbReference type="OMA" id="RRWWSEY"/>
    <dbReference type="OrthoDB" id="5527234at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056289">
        <property type="entry name" value="CEP76_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24654">
        <property type="entry name" value="CEP76_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="79"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5431606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="627" mass="69038" checksum="28EF6F7A13111BA4" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X1X6</accession>
    <name>A0A3S7X1X6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_280032400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280032400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.3700"/>
    <dbReference type="OrthoDB" id="245103at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1556" mass="165075" checksum="4A8E389B3281E62F" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X299</accession>
    <name>A0A3S7X299_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinesin, putative</fullName>
            <ecNumber evidence="12">3.6.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LdCL_290014200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.4" evidence="12"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290014200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.1450"/>
    <dbReference type="OrthoDB" id="249110at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000042">
        <property type="entry name" value="Kinesin family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="26"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="391"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="657"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="743"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1348"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1459"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYU80579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1665" mass="192823" checksum="2797B68450533E80" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2R6</accession>
    <name>A0A3S7X2R6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_290031600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2R6"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292550.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290031600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3790"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000021">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="386"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="462"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="724" mass="81348" checksum="11F56071CEDF0E2E" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2W5</accession>
    <accession>E9BL64</accession>
    <name>A0A3S7X2W5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_28815</name>
        <name evidence="4" type="ORF">LDBPK_292670</name>
        <name evidence="2" type="ORF">LdCL_290032800</name>
        <name evidence="3" type="ORF">LDHU3_29.3940</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812649">
        <property type="protein sequence ID" value="CAC5431984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799616">
        <property type="protein sequence ID" value="CBZ35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000014">
        <property type="protein sequence ID" value="TPP52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862685.1">
        <property type="nucleotide sequence ID" value="XM_003862637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2W5"/>
    <dbReference type="GeneID" id="13385388"/>
    <dbReference type="KEGG" id="ldo:LDBPK_292670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_292670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290032800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.3940"/>
    <dbReference type="OMA" id="SYIDEMP"/>
    <dbReference type="OrthoDB" id="276733at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF6">
        <property type="entry name" value="CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5431984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="340" mass="37986" checksum="5233D87CC05DC2EF" modified="2019-05-08" version="1">MTDKSVYGGLFQDPPYLSSDPDPKKTDPYDKKDAIPSRYLGKNMTIGGRVPPGQHPDAYFDKRFLTLASSEQNGGKPVDYDESKRLTAASKTNTKNAISDKEFCYSSYPEKSTGPGSYYGCFQNRPYEYMTEPWDDGKSKKKRTTKTKEEEPTHLPNIKTNPTKKGTYGYPGLLLSNPSYDDDWKKDYAAAEANRARRERKQGPAPKALGPPFHIPGVSHSYIDEMPNTGVSAVYAAYEAPADSAAAKRKAKREAAAAPTLVHERAFYGSANRSGEPGCLNPFPNVWVHPDETQPSKFALRKQAQKEKEEAARQPKRTEVWRPNSFGKTSVVSSCLRRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X2Z0</accession>
    <name>A0A3S7X2Z0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300007500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X2Z0"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300240.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300007500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0380"/>
    <dbReference type="OrthoDB" id="298589at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="596" mass="66710" checksum="F6A1B0A65C52D09A" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3B7</accession>
    <name>A0A3S7X3B7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ama1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300019900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3B7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_301470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300019900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.1880"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU80944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19622" checksum="7558813C9D89B474" modified="2019-05-08" version="1">MPQGQYSQKPNGGPTQPVKTRPGQSVYTGNPMNAPGSRNAVHSRDADWHYSLCVCCDDMDSCCEACCCFTCQVSRQCNMFMYNRREIHWPYCLLMTLCDVSLFFFSVTCVFASETRRLARERYGISGSGIDDCCIGYWCRTCSAQQVLLEMTAMNEFPGATCYEAAPQPAANRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3K1</accession>
    <name>A0A3S7X3K1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calpain-like cysteine peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_300025700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302040.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300025700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.2770"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001552">
        <property type="entry name" value="Calpain-like cysteine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF423">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN (LRRP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="272"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1354" mass="148516" checksum="EEE93D2030F4C709" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X3S8</accession>
    <name>A0A3S7X3S8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_300037000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X3S8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_303140.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300037000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.4160"/>
    <dbReference type="OrthoDB" id="272213at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="698" mass="76514" checksum="A1C3BF8FE53FD3D2" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4A1</accession>
    <name>A0A3S7X4A1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CGC21_11855</name>
        <name evidence="8" type="ORF">LdCL_310015000</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4A1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310910.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310015000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1430"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="83"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU81279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TPP42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="480" mass="52375" checksum="753BE1657C2C6EA1" modified="2019-05-08" version="1">MSKPSESIPAQAEGEVLSDSLIDGNPGNAVDKHPSGEQGNHLHKNGSLTASSSHNDNGADAAKPGRNIIFRFTGWLIPYGGVISNCFSLGSVTLGGGIISMPSSFAMSGIIMSVIYLVVITAATVYTMTLLGYAMKATGCKTFEELSLVLFGRGWDYFVGFVLWLSCFGTAVAYISAVSSLITPILEKSPGTPAYLLTTSGNRLITSLIWLVFMVPVVIPKRVNSIRYVSAIGVFMVLYFAVTIVVHSSMNGLKEGMRGDMKYFTSGNEAVYGLSIFIFSFLCQAVTGSVYFEQRPRPSVRQLTIASAISMTVCMVLYIFTGVFGYFDFADDTQDSILYNFDPVHQPYMMIAYIGMLIKICAAFAMNMLPCRNFAYHCLNWDLETVPYWKHTIAILTMAVATLVCGLFIPSINTAFGLVGSLCGGFIGFIFPAYFWMYSGNWSLSSVGIWHWLATYFLVVAGVIAVVFGTVSTVYFSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X4C9</accession>
    <accession>E9BMP2</accession>
    <name>A0A3S7X4C9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5-like Heme/Steroid binding domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cytochrome b5-like Heme/Steroid binding domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CGC21_11660</name>
        <name evidence="4" type="ORF">LDBPK_311180</name>
        <name evidence="3" type="ORF">LdCL_310018500</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000006">
        <property type="protein sequence ID" value="TPP42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863209.1">
        <property type="nucleotide sequence ID" value="XM_003863161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X4C9"/>
    <dbReference type="SMR" id="A0A3S7X4C9"/>
    <dbReference type="GeneID" id="13385928"/>
    <dbReference type="KEGG" id="ldo:LDBPK_311180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_311180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310018500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.1930"/>
    <dbReference type="OMA" id="LMSARWR"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ36520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="121" mass="13143" checksum="720975BC3F428E10" modified="2019-05-08" version="1">MPPTDEPCVRVSYKNSHYLVPVEFILRVHPGGQQLILQYVNQDITQAFVDARHSDTAVQLLEQWMEGAPAGPRRIMPSSAAATEAPLNGHGGDGRYAQMIWNALVFGIAGASATAAVLCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6A2</accession>
    <name>A0A3S7X6A2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LdCL_330005600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6A2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330005600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0080"/>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001167">
        <property type="entry name" value="Hypothetical_protein_-_conserved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF3">
        <property type="entry name" value="TOG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYU81972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="695" mass="75790" checksum="6C95CB3122C11FEE" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X6T5</accession>
    <name>A0A3S7X6T5_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_330021600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X6T5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331500.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330021600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2230"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="589" mass="64712" checksum="D2C98490B7CDA92B" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X749</accession>
    <accession>E9BPP4</accession>
    <name>A0A3S7X749_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC21_37080</name>
        <name evidence="3" type="ORF">LDBPK_333060</name>
        <name evidence="2" type="ORF">LdCL_330037900</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000007">
        <property type="protein sequence ID" value="TPP53565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864130.1">
        <property type="nucleotide sequence ID" value="XM_003864082.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13392526"/>
    <dbReference type="KEGG" id="ldo:LDBPK_333060"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_333060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330037900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.4440"/>
    <dbReference type="OMA" id="ICGACIM"/>
    <dbReference type="OrthoDB" id="273057at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615:SF6">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35615">
        <property type="entry name" value="PRESENT IN THE OUTER MITOCHONDRIAL MEMBRANE PROTEOME 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP53565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="1593" mass="169499" checksum="3F04715E2DA04374" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X8Q9</accession>
    <name>A0A3S7X8Q9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_350007900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_350290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350007900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.0380"/>
    <dbReference type="OrthoDB" id="272972at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037727">
        <property type="entry name" value="MCAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35248:SF2">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35248">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1436" mass="144958" checksum="ABCD96F751211381" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7X9C1</accession>
    <accession>E9BS50</accession>
    <name>A0A3S7X9C1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CGC20_0170</name>
        <name evidence="5" type="ORF">CGC21_6380</name>
        <name evidence="4" type="ORF">LDBPK_351750</name>
        <name evidence="2" type="ORF">LdCL_350022400</name>
        <name evidence="3" type="ORF">LDHU3_35.2310</name>
    </gene>
    <organism evidence="2 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">LdCL</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="10" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="3" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812655">
        <property type="protein sequence ID" value="CAC5434197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000003">
        <property type="protein sequence ID" value="TPP44443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000029">
        <property type="protein sequence ID" value="TPP46376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864759.1">
        <property type="nucleotide sequence ID" value="XM_003864711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7X9C1"/>
    <dbReference type="GeneID" id="13387639"/>
    <dbReference type="KEGG" id="ldo:LDBPK_351750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_351750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350022400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.2310"/>
    <dbReference type="OMA" id="KWGFLFK"/>
    <dbReference type="OrthoDB" id="238257at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5434197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ38079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP44443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TPP46376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="140" mass="15716" checksum="F1AD27DED938F9CD" modified="2019-05-08" version="1">MLRTRLSLAPMLSKATRLQLGNIKTEYGTVSTAAGSVEKWGFLFGGNMYPIVSISFSIFMVCATVVVVATYQQYRDMAIVTEHISYEDVKDRCLTPMPGWARLRSFSMATPQGPATFRDPTPLDWLPFELKLGYVKQSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XAQ9</accession>
    <accession>E9BTR6</accession>
    <name>A0A3S7XAQ9_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CGC20_28920</name>
        <name evidence="18" type="ORF">CGC21_13325</name>
        <name evidence="16" type="ORF">LDBPK_362070</name>
        <name evidence="14" type="ORF">LdCL_360026200</name>
        <name evidence="15" type="ORF">LDHU3_36.2690</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14 20" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">LdCL</strain>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="17" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">FDAARGOS_360</strain>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="22" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="15" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000002">
        <property type="protein sequence ID" value="TPP42242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000054">
        <property type="protein sequence ID" value="TPP48315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865322.1">
        <property type="nucleotide sequence ID" value="XM_003865274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XAQ9"/>
    <dbReference type="SMR" id="A0A3S7XAQ9"/>
    <dbReference type="GeneID" id="13388208"/>
    <dbReference type="KEGG" id="ldo:LDBPK_362070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_362070.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360026200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2690"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYU83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC5434777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CBZ38645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TPP42242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TPP48315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="247" mass="28142" checksum="6602772FB825D4A8" modified="2019-05-08" version="1">MTSKVILLFDVDGTLTPPRNPETLDMKQTLAKVRAAGFKLGVVGGSDFAKQKEQLGESILEDFDYVFSENGLLAYKDGKEFHRNSLLKALGNEKVVAFVKKCLHLIADLDIPVQRGTFVEFRNGMFNVSPIGRNCSQQERDEFEQLDKERHIREKLIRNLKEAFPDYPLAYSVGGQISFDVFPKGWDKTYCLQFVENDFQTIHFFGDKTSEGGNDYEIYTDCRTIGHSVKTYKDTIAILESLLEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBH2</accession>
    <name>A0A3S7XBH2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LdCL_360046900</name>
        <name evidence="12" type="ORF">LDHU3_36.5340</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812656">
        <property type="protein sequence ID" value="CAC5434977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBH2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_364000.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360046900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.5340"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000003">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5434977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="377" mass="41569" checksum="4AB69AFEE7E7655C" modified="2019-05-08" version="1">MSASLKKTALHSFHLAQQAKMDAFAGYHMPISYGRFGVLKEHLYTRQVAGIFDVSHVGQYEVRGADREKFMEHVTPVDLQRTRAGQGALTMLTNAQGGIKDDCIVTRMADHLFLVLNAGCKEKDVAHMERVLREGAMKGADVQLVPLDRSLIALQGPQAAAILSEFMDDVPDMGFMQCRQRVSIKGMEVQVTRCGYTGEDGFEMSVSNTDIVAFVELLMSRKAEMIGLGARDSLRLEAGLNLYGHELTEDINPVAARFMWAISKRRMAEGGFIGYEPIKYFRDNASKGAVPRLRVGLVSTGPVAREKTVIEVGGKPVGEVTSGCPSPCLKKNIAIGYLDRKLAKDGAKVDLVVRGRRVAAEVVTPRFVPTRYYRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3S7XBW9</accession>
    <name>A0A3S7XBW9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LdCL_360061000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3S7XBW9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_365380.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360061000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.7200"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000216">
        <property type="entry name" value="Kinesin-like protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="9"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="433"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="625" mass="71244" checksum="10021240B6A152A0" modified="2019-05-08" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJH9</accession>
    <name>A0A451EJH9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane amino acid transporter protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_020009500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029501">
        <property type="protein sequence ID" value="AYU75645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJH9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_020009500"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="298" mass="32462" checksum="C999D226F4FCC2EE" modified="2019-05-08" version="1">MLPLCLPRRVASLRYFSIIGVTLVICFVLAVVAHSSTAGLPHLHELKYFATGIDAVNGLTLFIFAFLGHGLCFRLFDEMRHPSARDLLLDACGSVSLIGMLCFVVGFFGYAEFGLDISGSILKYYHVRSDPMMLAAYMGILLKICVAYALSGQACRLPIFYILKNDIDSCPYQLHLGITAPLCVCSLILGLLMPDINIGFNLLGSMCGGVLAFLLPSFLVYLGGWTLHRVGWVRMGLTYVNMIAGVLAIVFGTAVTIGDMVKRYGWAAAGTYERGVVRVAAHEVALLGAWWHATHTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A451EJM2</accession>
    <accession>E9B7N4</accession>
    <name>A0A451EJM2_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_030160</name>
        <name evidence="2" type="ORF">LdCL_030006600</name>
        <name evidence="3" type="ORF">LDHU3_03.0160</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029502">
        <property type="protein sequence ID" value="AYU75692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812623">
        <property type="protein sequence ID" value="CAC5427047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799590">
        <property type="protein sequence ID" value="CBZ31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857982.1">
        <property type="nucleotide sequence ID" value="XM_003857934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A451EJM2"/>
    <dbReference type="GeneID" id="13390356"/>
    <dbReference type="KEGG" id="ldo:LDBPK_030160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_030160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_030006600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_03.0160"/>
    <dbReference type="OMA" id="KPQQETF"/>
    <dbReference type="OrthoDB" id="265203at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU75692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5427047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="192" mass="19826" checksum="4863A4D8437795CB" modified="2019-05-08" version="1">MSSPYSPPRAVVTDNSKDDAFLVKDLTLLMAALRLNNSDDWAGKPQQETFRVYETMPPVATAQPSPCSADVGDAARGSSPHDSDKSDASSDSLSTLMTGYVHAVRALHAFDAQMAADGIRESATAEAGHTGGGVVGAEEEATTPCKAAADDGSSSAANTKRAEAAAPVDMAELLAAPDLLPCLMIDEQGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>E9B785</accession>
    <accession>A0A3S5H4T8</accession>
    <name>E9B785_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LDBPK_010210</name>
        <name evidence="7" type="ORF">LdCL_010007100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857834.1">
        <property type="nucleotide sequence ID" value="XM_003857786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B785"/>
    <dbReference type="SMR" id="E9B785"/>
    <dbReference type="GeneID" id="13390030"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010210"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010210.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010007100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0230"/>
    <dbReference type="OMA" id="NRMAMLA"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="PhylomeDB" id="E9B785"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.110:FF:000012">
        <property type="entry name" value="UBA/TS-N_domain/CUE_domain/Domain_of_uncharacterized_function_(DUF1771)/Smr_domain_containing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="564"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="5">
        <location>
            <begin position="813"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU75532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CBZ31108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="898" mass="96008" checksum="BBFE67F17574FD3D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>E9B7D0</accession>
    <accession>A0A3S5H4W3</accession>
    <name>E9B7D0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_010660</name>
        <name evidence="5" type="ORF">LdCL_010011600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029500">
        <property type="protein sequence ID" value="AYU75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799588">
        <property type="protein sequence ID" value="CBZ31153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003857879.1">
        <property type="nucleotide sequence ID" value="XM_003857831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9B7D0"/>
    <dbReference type="GeneID" id="13389720"/>
    <dbReference type="KEGG" id="ldo:LDBPK_010660"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_010660.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_010011600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_01.0740"/>
    <dbReference type="OMA" id="FEEWCRP"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="PhylomeDB" id="E9B7D0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="903"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="924"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ31153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1109" mass="117122" checksum="A906296AD25D4CC7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BDJ3</accession>
    <accession>A0A3Q8IB11</accession>
    <name>E9BDJ3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARF-like 2-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_180120</name>
        <name evidence="1" type="ORF">LdCL_180006100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU77938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799605">
        <property type="protein sequence ID" value="CBZ33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860026.1">
        <property type="nucleotide sequence ID" value="XM_003859978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BDJ3"/>
    <dbReference type="GeneID" id="13393476"/>
    <dbReference type="KEGG" id="ldo:LDBPK_180120"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_180120.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180006100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.0130"/>
    <dbReference type="OMA" id="EGCFDYE"/>
    <dbReference type="OrthoDB" id="302784at2759"/>
    <dbReference type="PhylomeDB" id="E9BDJ3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU77938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14520" checksum="A2F17C44ED56571C" modified="2011-04-05" version="1">MDTEEGEFIICGNGGSSEDAAFDAVVGVIEDFMISFDPEQVWQSVPPLHTVSDDHDQHTVYTSFLEKVDQELDAHVLAACPEYKSIEEVVTLLQKRHEDITEEVWAFVSEGCFDYEAFMEQWKEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BED6</accession>
    <accession>A0A3S5H773</accession>
    <name>E9BED6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-RNA processing PIH1/Nop17, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LDBPK_191470</name>
        <name evidence="4" type="ORF">LdCL_190020500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">LdCL</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029518">
        <property type="protein sequence ID" value="AYU78254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799606">
        <property type="protein sequence ID" value="CBZ33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003860319.1">
        <property type="nucleotide sequence ID" value="XM_003860271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BED6"/>
    <dbReference type="GeneID" id="13386131"/>
    <dbReference type="KEGG" id="ldo:LDBPK_191470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_191470.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_190020500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_19.1790"/>
    <dbReference type="OMA" id="AYCVDVV"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="PhylomeDB" id="E9BED6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF8">
        <property type="entry name" value="PIH1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU78254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CBZ33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="365" mass="39733" checksum="7294F7F9391383E8" modified="2011-04-05" version="1">MLTASGLMVGFAFVAKTADESCSYIVNVCGHDSVGPPLARSMNAVDTEYVEHRGVDNLIIPISVSEPKETKSGDYAYCVDVVVHTLLIKKCSPGHRLLQHLTEKLVTLSMEWIRNECGVQLLPRSCRIAGNPLYYDDTVETSKSMTSIIENAAALLQRKSNSSFTRKNEQDTIPDALDLMKAQVPECKQPRIREVISTPAIKKGFLVDGNARLYGPDGSSEGSGKAPDPLSHIPQSLRERCQIIDTRNVEGLTVPPAKTLKSVDKTANTHTSGTIVAPTSELQGKDEASWARFSIERTGEKVIVRFLVPDSVSSLHDIDLSATKGTLEINGSVTQLPVPIVTDDVQAKFVKSTRILIVTCMIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BGC6</accession>
    <accession>A0A3S7WXU3</accession>
    <name>E9BGC6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_231080</name>
        <name evidence="8" type="ORF">LdCL_230017900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799610">
        <property type="protein sequence ID" value="CBZ34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861006.1">
        <property type="nucleotide sequence ID" value="XM_003860958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BGC6"/>
    <dbReference type="GeneID" id="13390205"/>
    <dbReference type="KEGG" id="ldo:LDBPK_231080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_231080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230017900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_23.1440"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="PhylomeDB" id="E9BGC6"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000005">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="447" mass="50939" checksum="EE99BF87452AE72C" modified="2011-04-05" version="1">MGPSSSGSSVAAPFMRHYRAGLLRSTPARLAMNLHASDLSTPDRATVNSANKKEFKTALCNELVNKITAQGYYPMSQFVKDCLTHPQYGYYAAKKNVIGSEKADFITAAEIPFFGDVLAAWVMDAWQKMGTPRVLHLVEMGPGRGTLMRTMLKQIQYSNPHLLHFLQIHLVEVGAARREEQKRALTEFQTAQGKIKWWMDLESLPFSLEPTVFIANEYFDALPVAQFRYTERGWVETCVEVDTDPGTEAHFRLVHAPSGSMSAYLIPDDIRTKGKTGDCVEVNTVGMQTMETLMKKMIDCQKAACLLIDYGKDDHMHSTLRGIRGHRFVDPLLSPGEVDLSCWVSFRQLRWALERLEVARRHLKWFPVMTQHEFLLENGIDIRLAHVIKDEETKTALKVLQNYRRLMDKEEMGESYKVFAFQTRNFPNVSPFFAEMPLPPLPQRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>E9BHM6</accession>
    <accession>A0A3Q8INE9</accession>
    <name>E9BHM6_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CGC20_2335</name>
        <name evidence="14" type="ORF">CGC20_26645</name>
        <name evidence="12" type="ORF">CGC21_25565</name>
        <name evidence="13" type="ORF">CGC21_8675</name>
        <name evidence="10" type="ORF">LDBPK_251220</name>
        <name evidence="11" type="ORF">LDBPK_340460</name>
        <name evidence="6" type="ORF">LdCL_250018000</name>
        <name evidence="7" type="ORF">LdCL_340009700</name>
        <name evidence="8" type="ORF">LDHU3_25.1560</name>
        <name evidence="9" type="ORF">LDHU3_34.0630</name>
    </gene>
    <organism evidence="10 16">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 16" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="1589" last="1589">
            <title>Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.</title>
            <authorList>
                <person name="Shalev-Benami M."/>
                <person name="Zhang Y."/>
                <person name="Rozenberg H."/>
                <person name="Nobe Y."/>
                <person name="Taoka M."/>
                <person name="Matzov D."/>
                <person name="Zimmerman E."/>
                <person name="Bashan A."/>
                <person name="Isobe T."/>
                <person name="Jaffe C.L."/>
                <person name="Yonath A."/>
                <person name="Skiniotis G."/>
            </authorList>
            <dbReference type="PubMed" id="29150609"/>
            <dbReference type="DOI" id="10.1038/s41467-017-01664-4"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS)</scope>
    </reference>
    <reference evidence="6 17" key="5">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 17">LdCL</strain>
        </source>
    </reference>
    <reference evidence="18" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="19" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="8">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">FDAARGOS_360</strain>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="9">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812645">
        <property type="protein sequence ID" value="CAC5430699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000004">
        <property type="protein sequence ID" value="TPP39959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000022">
        <property type="protein sequence ID" value="TPP48910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861452.1">
        <property type="nucleotide sequence ID" value="XM_003861404.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864211.1">
        <property type="nucleotide sequence ID" value="XM_003864163.1"/>
    </dbReference>
    <dbReference type="PDB" id="6AZ1">
        <property type="method" value="EM"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="a=1-120"/>
    </dbReference>
    <dbReference type="PDBsum" id="6AZ1"/>
    <dbReference type="AlphaFoldDB" id="E9BHM6"/>
    <dbReference type="EMDB" id="EMD-7024"/>
    <dbReference type="SMR" id="E9BHM6"/>
    <dbReference type="GeneID" id="13388698"/>
    <dbReference type="GeneID" id="13392620"/>
    <dbReference type="KEGG" id="ldo:LDBPK_251220"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340460"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_251220.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340460.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250018000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340009700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.1560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.0630"/>
    <dbReference type="OMA" id="CASAYEM"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000678">
        <property type="entry name" value="Ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU79458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5430699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5433597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ37529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP39959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP40737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TPP48910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TPP50493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6AZ1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13046" checksum="0F1910117908B4CB" modified="2011-04-05" version="1">MPPKAGQTKKAKMEAANKGAKKTTKKWSKGQSREALQNAVMFDKETYDKLRSEVPKYKLITPSIISDRLKIAVSIAAAGLKQLCREKLIRLVSCSSKTRVYTRIVQAAPAEAAAAAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMG4</accession>
    <accession>A0A3Q8IEN7</accession>
    <name>E9BMG4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_310400</name>
        <name evidence="2" type="ORF">LdCL_310009100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863132.1">
        <property type="nucleotide sequence ID" value="XM_003863084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="13385852"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310400.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310009100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0480"/>
    <dbReference type="OMA" id="WRWADAS"/>
    <dbReference type="OrthoDB" id="273429at2759"/>
    <dbReference type="PhylomeDB" id="E9BMG4"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1380" mass="149647" checksum="50BE30DC8ED54CBF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>E9BMJ0</accession>
    <accession>A0A3S7X476</accession>
    <name>E9BMJ0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_310670</name>
        <name evidence="2" type="ORF">LdCL_310012400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029530">
        <property type="protein sequence ID" value="AYU81253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799618">
        <property type="protein sequence ID" value="CBZ36468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863157.1">
        <property type="nucleotide sequence ID" value="XM_003863109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BMJ0"/>
    <dbReference type="GeneID" id="13385878"/>
    <dbReference type="KEGG" id="ldo:LDBPK_310670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_310670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_310012400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_31.0970"/>
    <dbReference type="OMA" id="PRAGHFF"/>
    <dbReference type="OrthoDB" id="278744at2759"/>
    <dbReference type="PhylomeDB" id="E9BMJ0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="CDD" id="cd23742">
        <property type="entry name" value="RESC12-12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU81253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="924" mass="101298" checksum="FAB8D0710F3552CD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>E9BNI0</accession>
    <accession>A0A3Q8IFR4</accession>
    <name>E9BNI0_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pan3 C-terminal knob domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LDBPK_320760</name>
        <name evidence="9" type="ORF">LdCL_320013200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029531">
        <property type="protein sequence ID" value="AYU81623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799619">
        <property type="protein sequence ID" value="CBZ36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863494.1">
        <property type="nucleotide sequence ID" value="XM_003863446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BNI0"/>
    <dbReference type="GeneID" id="13390306"/>
    <dbReference type="KEGG" id="ldo:LDBPK_320760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_320760.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_320013200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_32.0960"/>
    <dbReference type="OMA" id="YVFHSVD"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="PhylomeDB" id="E9BNI0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000003">
        <property type="entry name" value="Pab1p-dependent poly(A) ribonuclease subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001015">
        <property type="entry name" value="Pab1p-dependent poly(A) ribonuclease subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000004">
        <property type="entry name" value="Pab1p-dependent poly(A) ribonuclease subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="8">
        <location>
            <begin position="325"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYU81623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="481" mass="54543" checksum="54424925862DDAD0" modified="2011-04-05" version="1">MNPVTGGIPGVANGAQMMSPTFPSPHSLYSPQHHMDVYRTNGSLSLAADPFPATPYTPISSLFMSPSVRNSLTTPHSVRPRRPVTHVTSSKFSMYTTIYNLEPEPKPSVMMPKVRMQIYQTSARYTGKDILLRRLVNVPVKEEECAAVKEALRQYRHPNLVPLTNLFATEEFVMGSTDVIMEYRYMSGAKSLQEAFFTEGRRATEGLLWSFTCQLVGLLRSFHETLIPLHGLHWSKIIYVETTGRFYFTGLGLTDLLEPRGTTVQQHILMKQDIQALGFILFQLASRNLNAKLETFTNKQPLPGFSQSFWELIKTCLEGHADSAQLCHALGERMSMEVGHQEGHTDFLMSQCQKEMHNGRVMRLLIKLSFALESPAEVHEYTSENQRYVLRLFNQFLFNQVDEQNRVNVDWGHVYHCLNKLDIGSDETIQLIGTDTSNTVLVVSYADLRAMLDSVFDRVQQVSQMTTDVDPQRYTMTPGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPH0</accession>
    <accession>A0A3Q8IEZ5</accession>
    <name>E9BPH0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_332310</name>
        <name evidence="2" type="ORF">LdCL_330030100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864056.1">
        <property type="nucleotide sequence ID" value="XM_003864008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPH0"/>
    <dbReference type="GeneID" id="13392452"/>
    <dbReference type="KEGG" id="ldo:LDBPK_332310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_332310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330030100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.3350"/>
    <dbReference type="OMA" id="MACPTEK"/>
    <dbReference type="OrthoDB" id="267177at2759"/>
    <dbReference type="PhylomeDB" id="E9BPH0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="767" mass="81865" checksum="BA2611F62EAF6DE3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>E9BPT2</accession>
    <accession>A0A3S5H7T6</accession>
    <name>E9BPT2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="3">2.7.7.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LDBPK_330030</name>
        <name evidence="5" type="ORF">LdCL_330005200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="3"/>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863827.1">
        <property type="nucleotide sequence ID" value="XM_003863779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BPT2"/>
    <dbReference type="GeneID" id="13391592"/>
    <dbReference type="KEGG" id="ldo:LDBPK_330030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330030.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330005200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0040"/>
    <dbReference type="OMA" id="YSKNRMM"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="PhylomeDB" id="E9BPT2"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ37144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="556" mass="62340" checksum="65BADC2CA4D146B1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQ98</accession>
    <accession>A0A3Q8IHT9</accession>
    <name>E9BQ98_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_331670</name>
        <name evidence="2" type="ORF">LdCL_330023300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799620">
        <property type="protein sequence ID" value="CBZ37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003863993.1">
        <property type="nucleotide sequence ID" value="XM_003863945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQ98"/>
    <dbReference type="GeneID" id="13392388"/>
    <dbReference type="KEGG" id="ldo:LDBPK_331670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_331670.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330023300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.2510"/>
    <dbReference type="OMA" id="FARHWTE"/>
    <dbReference type="OrthoDB" id="272988at2759"/>
    <dbReference type="PhylomeDB" id="E9BQ98"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU82145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="512" mass="56145" checksum="105C1C104B331BED" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQL3</accession>
    <accession>A0A3Q8IH98</accession>
    <name>E9BQL3_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="10">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor 4 homolog</fullName>
            <shortName evidence="10">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LDBPK_340590</name>
        <name evidence="13" type="ORF">LdCL_340011500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">LdCL</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="10"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864224.1">
        <property type="nucleotide sequence ID" value="XM_003864176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQL3"/>
    <dbReference type="GeneID" id="13392633"/>
    <dbReference type="KEGG" id="ldo:LDBPK_340590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_340590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1000"/>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="PhylomeDB" id="E9BQL3"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000187">
        <property type="entry name" value="Translation factor GUF1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002566">
        <property type="entry name" value="Translation factor GUF1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="129"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="259"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYU82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CBZ37542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="834" mass="90553" checksum="FDDD0654A3824812" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BQT6</accession>
    <accession>A0A3Q8IN62</accession>
    <name>E9BQT6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LDBPK_341350</name>
        <name evidence="1" type="ORF">LdCL_340019500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799621">
        <property type="protein sequence ID" value="CBZ37615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864297.1">
        <property type="nucleotide sequence ID" value="XM_003864249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BQT6"/>
    <dbReference type="GeneID" id="13392706"/>
    <dbReference type="KEGG" id="ldo:LDBPK_341350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_341350.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340019500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.2110"/>
    <dbReference type="OMA" id="RDTIWQA"/>
    <dbReference type="OrthoDB" id="261449at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU82473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ37615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9691" checksum="EBD04358744B3A23" modified="2011-04-05" version="1">MELQEVDHLLEELTALLVSQESGRDDAAIEPAILNAVADYVEGVDSTGAGLEQLRQALEAAVGEDGNSAKQRMKAAGCGRAIRLLRDAVSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>E9BSE0</accession>
    <accession>A0A3Q8IGC1</accession>
    <name>E9BSE0_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_352700</name>
        <name evidence="2" type="ORF">LdCL_350031900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029534">
        <property type="protein sequence ID" value="AYU83069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799622">
        <property type="protein sequence ID" value="CBZ38169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003864849.1">
        <property type="nucleotide sequence ID" value="XM_003864801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BSE0"/>
    <dbReference type="GeneID" id="13387727"/>
    <dbReference type="KEGG" id="ldo:LDBPK_352700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_352700.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_350031900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_35.3450"/>
    <dbReference type="OMA" id="HEIWKLK"/>
    <dbReference type="OrthoDB" id="266402at2759"/>
    <dbReference type="PhylomeDB" id="E9BSE0"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="667" mass="71489" checksum="996A049CFB7F00A6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>E9BTQ8</accession>
    <accession>A0A3Q8IG15</accession>
    <name>E9BTQ8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LDBPK_361990</name>
        <name evidence="2" type="ORF">LdCL_360025400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029535">
        <property type="protein sequence ID" value="AYU83544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799623">
        <property type="protein sequence ID" value="CBZ38637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003865314.1">
        <property type="nucleotide sequence ID" value="XM_003865266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E9BTQ8"/>
    <dbReference type="GeneID" id="13388200"/>
    <dbReference type="KEGG" id="ldo:LDBPK_361990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_361990.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_360025400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_36.2590"/>
    <dbReference type="OMA" id="HSILGQP"/>
    <dbReference type="OrthoDB" id="265900at2759"/>
    <dbReference type="PhylomeDB" id="E9BTQ8"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 36"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU83544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ38637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="414" mass="43724" checksum="E4BA921937F1FDFE" modified="2011-04-05" version="1">MKRRDVSAPPHRSYAASTGSSTTTMSSASPPAISTMCVDVRELLRHTAAASKDAPSDAQAAVSGRQRYTAVAPSAAPSQPPRQPQATPPPCPKESTFWSPSYPPWGGFAVNSGPPPLSPTDATILHSILGQPTVQKTVLSGFDQVIARTSSPLTREPRTRRPSVASTSLPPMDNSPTWGTPAYAGDSVQTFEVGAATPLSSLSEKDTPPPTPLRDMMETYLDGEGLHSAGAAASMDFSPAAQRTMKSILEQLNSYASGLAAAHTRAATEMPTSSYRGGVAVWPITFRQAAMQVSAAGPSAASPLPFSGASVHRRKGGAVATRSTVAQLWRQCPALAASTFSRVDTSPQRSQDTVQAVVAPPQGLAYDRPHAAADRSTVPLRKAVQSLPRTVPPAFRRQLQFAEEAPTTRRPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8I8V9</accession>
    <accession>E9BBZ3</accession>
    <name>A0A3Q8I8V9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LDBPK_141110</name>
        <name evidence="2" type="ORF">LdCL_140016800</name>
        <name evidence="3" type="ORF">LDHU3_14.1380</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029513">
        <property type="protein sequence ID" value="AYU77360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812634">
        <property type="protein sequence ID" value="CAC5428651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799601">
        <property type="protein sequence ID" value="CBZ32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859478.1">
        <property type="nucleotide sequence ID" value="XM_003859430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8I8V9"/>
    <dbReference type="GeneID" id="13391437"/>
    <dbReference type="KEGG" id="ldo:LDBPK_141110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_141110.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_140016800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_14.1380"/>
    <dbReference type="OMA" id="AHNPTQS"/>
    <dbReference type="OrthoDB" id="271029at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU77360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC5428651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CBZ32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22804" checksum="76CC8774E18D3440" modified="2019-04-10" version="1">MELYLLPETDSFSQVFLRPTFAVPFSVMTSLTLAANYFMEKSTVESSSAPAVLVTATFCVNVFSFTLFIASITFSNSTQITRAIALGQSPPMKLSVLRSLPWPLSVVCGGQGDRKLVPFVLYSLIFPGTLVVASLHLISLGVNGLENSLFWQLPLQRYLAWSMLWRLVVATAVFTTNYLAAHNPTQSVLIPSTDTYRQPSNVGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAC8</accession>
    <name>A0A3Q8IAC8_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_210015900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAC8"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211090.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210015900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1290"/>
    <dbReference type="OrthoDB" id="262994at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028110">
        <property type="entry name" value="TMEM254"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14934">
        <property type="entry name" value="TMEM254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22306" checksum="2412D4298CE1B9B0" modified="2019-04-10" version="1">MPSEPKRATNGGTPAAAAAEAVQSSSRSDRLPYRHPLRLYLPVVIAFVLLNNLAFRVEVDATGKNLALPEYVRAIAMERYALRRAMAAGQVPTEPIPFNAFLFFEESVMGALLQAGLFLFRSLSGIQAVCVLAWLIHLFELGVCFRICWSCNASFAVTLRYMFCTCVGGFTQLSPLIKARDAWVEEMRATAAVTAAPQSKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAF5</accession>
    <name>A0A3Q8IAF5_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LdCL_210022000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">LdCL</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IAF5"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_211640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210022000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.1950"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="435"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU78627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="708" mass="78865" checksum="4EA31DE47933E241" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IAR4</accession>
    <name>A0A3Q8IAR4_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine peptidase, Clan CA, family C2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LdCL_210006500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">LdCL</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP029520">
        <property type="protein sequence ID" value="AYU78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_210160.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_210006500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_21.0170"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000034">
        <property type="entry name" value="Putative calpain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000262">
        <property type="entry name" value="Putative calpain-like cysteine peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF421">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="716"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYU78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1626" mass="180145" checksum="606E50E9C9740E1B" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IB35</accession>
    <accession>E9BJT9</accession>
    <name>A0A3Q8IB35_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein DPCD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CGC20_13040</name>
        <name evidence="8" type="ORF">CGC21_22535</name>
        <name evidence="6" type="ORF">LDBPK_282180</name>
        <name evidence="4" type="ORF">LdCL_280026900</name>
        <name evidence="5" type="ORF">LDHU3_28.2960</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4 10" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">FDAARGOS_360</strain>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="11" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="5" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPCD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812648">
        <property type="protein sequence ID" value="CAC5431601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799615">
        <property type="protein sequence ID" value="CBZ35623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000012">
        <property type="protein sequence ID" value="TPP40423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000012">
        <property type="protein sequence ID" value="TPP54348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862317.1">
        <property type="nucleotide sequence ID" value="XM_003862269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IB35"/>
    <dbReference type="GeneID" id="13387053"/>
    <dbReference type="KEGG" id="ldo:LDBPK_282180"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_282180.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280026900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.2960"/>
    <dbReference type="OMA" id="PILCEME"/>
    <dbReference type="OrthoDB" id="10256139at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026224">
        <property type="entry name" value="DPCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921:SF1">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14913">
        <property type="entry name" value="DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02065">
        <property type="entry name" value="PROTEINDPCD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYU80373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC5431601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CBZ35623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TPP40423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TPP54348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="198" mass="22314" checksum="E0DBE60BB7363AFD" modified="2019-04-10" version="1">MLAEPKSSVIRGDRKHITSKFTDGSELVEEYDVVTDSLLLRKRRTRNALGGFSEWSIEVGTEAPSRNLDRALIAESSGSPVVVRQDTKESYVVRIRNLPYPKDVFSVAVEREDGDSVGKIVVRTSNRKYFKRLAIPDLERARIPLESAHLSYDVQHQTLIIQYKKPLSVLTAEAAARKERASMPSKRVDDSSPDCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IBN3</accession>
    <name>A0A3Q8IBN3_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_230009950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029522">
        <property type="protein sequence ID" value="AYU78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_230450.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_230009950"/>
    <dbReference type="OrthoDB" id="265333at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1439" mass="153488" checksum="C4ED124474F701A7" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID49</accession>
    <accession>E9BHA9</accession>
    <name>A0A3Q8ID49_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CGC21_8130</name>
        <name evidence="2" type="ORF">LDBPK_250050</name>
        <name evidence="1" type="ORF">LdCL_250005400</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 5" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">LdCL</strain>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FDAARGOS_361</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799612">
        <property type="protein sequence ID" value="CBZ34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000018">
        <property type="protein sequence ID" value="TPP40628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861336.1">
        <property type="nucleotide sequence ID" value="XM_003861288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID49"/>
    <dbReference type="GeneID" id="13391505"/>
    <dbReference type="KEGG" id="ldo:LDBPK_250050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_250050.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250005400"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.0060"/>
    <dbReference type="OMA" id="MTGNPHT"/>
    <dbReference type="OrthoDB" id="259598at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU79333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CBZ34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TPP40628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <sequence length="171" mass="18739" checksum="868A8F18CEBEF362" modified="2019-04-10" version="1">MELASNFSLLHAKLSKLGFRDWDSVSEGDVMTGNPHTYSLFLQFLYHRFPAATAALIRKHDWFILEHSDENVGAATVRLLAAETGEVHGISGAQFGRCKYASAKVAMCHSLLRLLRSLTPQPSTERPPARVPIASRSPMSACKPAAALPAQPFAAALVDKRRRALNSLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID60</accession>
    <name>A0A3Q8ID60_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain, G-beta repeat, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LdCL_180019800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029517">
        <property type="protein sequence ID" value="AYU78074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID60"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_181440.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_180019800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_18.1840"/>
    <dbReference type="OrthoDB" id="2162425at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002564">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYU78074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="910" mass="97175" checksum="FC84AEE53ECFD798" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8ID63</accession>
    <accession>E9BIS0</accession>
    <name>A0A3Q8ID63_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-grasp domain/D-ala D-ala ligase C-terminus/SET domain containing protein, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">SET domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC21_32565</name>
        <name evidence="11" type="ORF">LDBPK_262590</name>
        <name evidence="10" type="ORF">LdCL_260031800</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_361</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029525">
        <property type="protein sequence ID" value="AYU79862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799613">
        <property type="protein sequence ID" value="CBZ35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000017">
        <property type="protein sequence ID" value="TPP41282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003861843.1">
        <property type="nucleotide sequence ID" value="XM_003861795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8ID63"/>
    <dbReference type="GeneID" id="13389091"/>
    <dbReference type="KEGG" id="ldo:LDBPK_262590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_262590.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_260031800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_26.3350"/>
    <dbReference type="OMA" id="FKHFQLK"/>
    <dbReference type="OrthoDB" id="2017037at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000093">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000078">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="119"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="344"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="8">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYU79862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CBZ35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP41282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="516" mass="58885" checksum="6C08DCDF54AABFF3" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDB6</accession>
    <accession>E9BC72</accession>
    <name>A0A3Q8IDB6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication Factor A 28 kDa subunit, putative</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Replication protein A C terminal family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Replication_Factor_A_28_kDa_subunit_putative/Gene DB:LmjF.15.0270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CGC20_30050</name>
        <name evidence="11" type="ORF">CGC21_1780</name>
        <name evidence="10" type="ORF">LDBPK_150310</name>
        <name evidence="8" type="ORF">LdCL_150008000</name>
        <name evidence="9" type="ORF">LDHU3_15.0400</name>
    </gene>
    <organism evidence="8 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="8 14" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="16" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">FDAARGOS_360</strain>
            <strain evidence="11">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="15" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029514">
        <property type="protein sequence ID" value="AYU77442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812635">
        <property type="protein sequence ID" value="CAC5428728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799602">
        <property type="protein sequence ID" value="CBZ32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000033">
        <property type="protein sequence ID" value="TPP47774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000037">
        <property type="protein sequence ID" value="TPP53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003859556.1">
        <property type="nucleotide sequence ID" value="XM_003859508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDB6"/>
    <dbReference type="GeneID" id="13392910"/>
    <dbReference type="KEGG" id="ldo:LDBPK_150310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_150310.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_150008000"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_15.0400"/>
    <dbReference type="OMA" id="CNELNYH"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000455">
        <property type="entry name" value="Replication Factor A 28 kDa subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU77442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC5428728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CBZ32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TPP47774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TPP53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="257" mass="27550" checksum="404A049BB1A4F96C" modified="2019-04-10" version="1">MLASTPGSNFGGAVASSNNSGGQQPQRRMHPIRPLTIKQMLEAQSVGGGVLVVDGREVTQATVVGRVLGYENANMASGGGAITAKHFGYRITDNTGMLVVRQWIDADRMQEPLPLNTHVRASGTVNVWQQNPIVTGTVVSMADSNEMNYHMLDAILTHFRLTQGNKRAPSSGVSIQNTASAVGMHNMLPGGDIKVLLTDLLVSFIKQHGSSGAGMSMDELTTSAQRYGFTHGDVRTAMRTLAAEGKVYQTHDNRFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDF1</accession>
    <name>A0A3Q8IDF1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ domain/C2H2 type zinc-finger (2 copies)/Zinc-finger of C2H2 type/Zinc-finger double-stranded RNA-binding, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LdCL_250028700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029524">
        <property type="protein sequence ID" value="AYU79566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDF1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_252290.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_250028700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_25.2770"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYU79566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="377" mass="43748" checksum="67515B5B20B759A4" modified="2019-04-10" version="1">MGEGRIRCYYEVLEVERKATYDEIRAAYKKKSLQYHPDKNYGNQEEAAMRFKEVQNAYSILSDADERAWYDSHREAILRGGDGTGDADELNLYEFFTAGCFDGFDDSESGFYAVYRKVFDMLIEEESDYDSRAKLWPGFGTSTSDWADVQKFYGHWRNFGTYKTFTWKDEYKVNEMEDRYSRRMAGRINSKARDGAKKEYVRTVQSLAQFVYRRDPRVKAELERQEEEEQAKREERERQEIERLKRRREANERVWAEAAEREAREEAERAARGEAMDGSILEMLYEKERQTKEMMRGNGGAGAHTAGFAMLGGDDDEVVTVFNCPACKKQFKSENQYKEHVRSNKHKTKLKQLAAKGTDVAALMGEKVEGSSGGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IDL9</accession>
    <name>A0A3Q8IDL9_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_280005500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029527">
        <property type="protein sequence ID" value="AYU80159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IDL9"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280060.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_280005500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_28.0080"/>
    <dbReference type="OrthoDB" id="277129at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="485" mass="51477" checksum="0233C875E9BB9E8B" modified="2019-04-10" version="1">MRRLGRRTLTSLALTAARRWIESQEPCTAEAIRELLQQAEKEQERRELAVDQRKVVFTAASSGDHHARIAAAETFDVAAAGLPRPPNFCYMNVSVDFACMVDAPEVVWFNMCKANGFTPSSVKAGSVHMLGGMVCHQRLGGGYIQVILGCIPDLETDSFTFDAVPDKDEIAAAGRAPPAVAFAMLDAGLTLQYEQVLSAHLSSLSSSLGKECPLVGGLYPPVGSVIGGGDPSGKLEDSIFFINDRVYRGSAAAVVLRSKLLKAHAASVVPSISLGSASVTDVACEGGVATVRALNNRLAMEVVKEVYSLPEIAEKPSKVFLGLRHGDVHVPVSFVGHPDSGELSCTLPPGISLVQSDTVDFLVDDVELDTEMAASLLINMEKRIAPIFVEKDINVAREARRNIVASSTAAFHFSHGGLNTVAKPEIPAVSLGSAGAIFAPSILQRCVGRSCPNAGFFSPGQVATVADLTSIFPRSSTYCFMQGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEF6</accession>
    <accession>E9BM18</accession>
    <name>A0A3Q8IEF6_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical_protein_conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CGC20_6460</name>
        <name evidence="5" type="ORF">CGC21_36085</name>
        <name evidence="3" type="ORF">LDBPK_302750</name>
        <name evidence="1" type="ORF">LdCL_300033100</name>
        <name evidence="2" type="ORF">LDHU3_30.3670</name>
    </gene>
    <organism evidence="1 7">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="1 7" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 7">LdCL</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">FDAARGOS_360</strain>
            <strain evidence="5">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="8" key="6">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FDAARGOS_361</strain>
        </source>
    </reference>
    <reference evidence="9" key="7">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="2" key="8">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000008">
        <property type="protein sequence ID" value="TPP43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLC01000011">
        <property type="protein sequence ID" value="TPP45826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862986.1">
        <property type="nucleotide sequence ID" value="XM_003862938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEF6"/>
    <dbReference type="SMR" id="A0A3Q8IEF6"/>
    <dbReference type="GeneID" id="13385695"/>
    <dbReference type="KEGG" id="ldo:LDBPK_302750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_302750.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300033100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.3670"/>
    <dbReference type="OMA" id="DILDHWV"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318447">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC5432299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CBZ36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TPP43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TPP45826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000318447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="234" mass="27222" checksum="8C6FC3659E9FD54F" modified="2019-04-10" version="1">MLRQSSLLRFSTFALNPETSRAPHGPPRGLINRYISMGLPPWAAWCNRVNRHALYRMSDVSPRSFLPKAPHEMDVIWMNERIRERVRTSRQVQHVYRQLKYPFVKTGIHYSDTLDHWVQVPMVEAAMFEIEKDGGFDNFILKRSGPELRSTYGERIRRHLLVRQKETQKNFVLDQQAKTLAGVAHAELMKATSEEELDAVLSKYGMDAEEFKRLMAKRVMEQRKSLATAGLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEM7</accession>
    <accession>E9BLF8</accession>
    <name>A0A3Q8IEM7_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LDBPK_300640</name>
        <name evidence="7" type="ORF">LdCL_300011500</name>
        <name evidence="8" type="ORF">LDHU3_30.0820</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Genome Res." volume="21" first="2143" last="2156">
            <title>Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Decuypere S."/>
                <person name="Clark T.G."/>
                <person name="Coombs G.H."/>
                <person name="Cotton J.A."/>
                <person name="Hilley J.D."/>
                <person name="de Doncker S."/>
                <person name="Maes I."/>
                <person name="Mottram J.C."/>
                <person name="Quail M.A."/>
                <person name="Rijal S."/>
                <person name="Sanders M."/>
                <person name="Schonian G."/>
                <person name="Stark O."/>
                <person name="Sundar S."/>
                <person name="Vanaerschot M."/>
                <person name="Hertz-Fowler C."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22038251"/>
            <dbReference type="DOI" id="10.1101/gr.123430.111"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2011-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhao B.P."/>
                <person name="Ren Z.A."/>
                <person name="Li C.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2011-02" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance.</title>
            <authorList>
                <person name="Downing T."/>
                <person name="Imamura H."/>
                <person name="Sanders M."/>
                <person name="Decuypere S."/>
                <person name="Hertz-Fowler C."/>
                <person name="Clark T.G."/>
                <person name="Rijal S."/>
                <person name="Sundar S."/>
                <person name="Quail M.A."/>
                <person name="De Doncker S."/>
                <person name="Maes I."/>
                <person name="Vanaerschot M."/>
                <person name="Stark O."/>
                <person name="Schonian G."/>
                <person name="Dujardin J.C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">BPK282A1</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="4">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">LdCL</strain>
        </source>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP029529">
        <property type="protein sequence ID" value="AYU80860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812650">
        <property type="protein sequence ID" value="CAC5432081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FR799617">
        <property type="protein sequence ID" value="CBZ36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_003862778.1">
        <property type="nucleotide sequence ID" value="XM_003862730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEM7"/>
    <dbReference type="SMR" id="A0A3Q8IEM7"/>
    <dbReference type="GeneID" id="13385485"/>
    <dbReference type="KEGG" id="ldo:LDBPK_300640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_300640.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_300011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_30.0820"/>
    <dbReference type="OMA" id="KMVYDEA"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000008980">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU80860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC5432081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CBZ36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="216" mass="25021" checksum="CB40ADD2B4D22F65" modified="2019-04-10" version="1">MSEYQLDVGLLTVTDVSTVSGPMRREEDLMSSCTNALKALLGEFVDLPTEVKKTKYESATTLVQLPQPVMQLPREKAPPKTKPLTAWQKFALKKGIDIHRKKANRVFDEDRQVWKDKWGKRAREDRDKYDWLREVKPGYMPAEDGGDPFLDDRRAKQARLEKQKKKEEHNKRRSEHLMQAQEEVKHLSAAARNLATASNGKFEKTKKFKKNTKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IEY1</accession>
    <name>A0A3Q8IEY1_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LdCL_290005700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IEY1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_290080.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290005700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.0110"/>
    <dbReference type="OrthoDB" id="270382at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYU80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13688" checksum="6A8D443C0C560AFC" modified="2019-04-10" version="1">MSHSPFLTALYADVQSRLPLWITQYVKPVSDGAFAVSSTWTDDSGAQLQRLFIAVEASDTNNISEAVLTEWIALVEAWQTAHKEDEVSCFVGFVDLAGTVSYYRCETAVAGVLRSKPDDHLTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IF77</accession>
    <name>A0A3Q8IF77_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_290022800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">LdCL</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP029528">
        <property type="protein sequence ID" value="AYU80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IF77"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_291720.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_290022800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_29.2470"/>
    <dbReference type="OrthoDB" id="266893at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYU80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="1012" mass="105214" checksum="0C450B8ECB8C72DA" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IFB2</accession>
    <name>A0A3Q8IFB2_LEIDO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CGC20_2120</name>
        <name evidence="11" type="ORF">LdCL_340013900</name>
        <name evidence="12" type="ORF">LDHU3_34.1340</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">LdCL</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Vavikolanu K."/>
                <person name="Vyas G."/>
                <person name="Nadendla S."/>
                <person name="Aluvathingal J."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-02" db="EMBL/GenBank/DDBJ databases">
            <title>FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.</title>
            <authorList>
                <person name="Duncan R."/>
                <person name="Fisher C."/>
                <person name="Tallon L.J."/>
                <person name="Sadzewicz L."/>
                <person name="Sengamalay N."/>
                <person name="Ott S."/>
                <person name="Godinez A."/>
                <person name="Nagaraj S."/>
                <person name="Nadendla S."/>
                <person name="Sichtig H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">FDAARGOS_360</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Camacho E."/>
                <person name="Gonzalez-de la Fuente S."/>
                <person name="Rastrojo A."/>
                <person name="Peiro-Pastor R."/>
                <person name="Solana JC."/>
                <person name="Tabera L."/>
                <person name="Gamarro F."/>
                <person name="Carrasco-Ramiro F."/>
                <person name="Requena JM."/>
                <person name="Aguado B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CP029533">
        <property type="protein sequence ID" value="AYU82420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LR812654">
        <property type="protein sequence ID" value="CAC5433643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="RHLD01000026">
        <property type="protein sequence ID" value="TPP50450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IFB2"/>
    <dbReference type="SMR" id="A0A3Q8IFB2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_280730.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_340013900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_34.1340"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000318821">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000601710">
        <property type="component" value="Chromosome 34"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000047">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF396">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYU82420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC5433643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TPP50450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000318821"/>
        </source>
    </evidence>
    <sequence length="300" mass="34450" checksum="BEB57C29D82A9237" modified="2019-04-10" version="1">MSESVFPLVQSIVEKMLTGGDNRFQRQILIKEEEIRAVLRAVREVFMSQPMLLEIRPPVRVCGDTHGQYYDLLRIYEKCGFPPYSNYLFLGDYVDRGKHSVETIVLQFCYKIVYPENFFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLSPDLTSVASVMDIERPCDVPDRGILCDLLWADPEDDVQGFLESDRGVSYLFGEDIVNDFLDMVDMDLIVRAHQVMERGYGFFASRQLVTVFSAPNYCGEFDNDAAVMNIDDKLQCSFLIIPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IGQ7</accession>
    <name>A0A3Q8IGQ7_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LdCL_330011500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">LdCL</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP029532">
        <property type="protein sequence ID" value="AYU82028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3Q8IGQ7"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdBPK_330600.1"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LdCL_330011500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:LDHU3_33.0880"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000274082">
        <property type="component" value="Chromosome 33"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYU82028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000274082"/>
        </source>
    </evidence>
    <sequence length="579" mass="63473" checksum="A4463C8BB0EE6D5E" modified="2019-04-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-04-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3Q8IH11</accession>
    <name>A0A3Q8IH11_LEIDO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LdCL_260017200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Leishmania donovani</name>
        <dbReference type="NCBI Taxonomy" id="5661"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Leishmaniinae</taxon>
            <taxon>Leishmania</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16549" last="16549">
            <title>A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.</title>
            <authorList>
                <person name="Lypaczewski P."/>
                <person name="Hoshizaki J."/>
                <person name="Zhang W.-W."/>
                <person name="McCall L.-I."/>
                <person name="Torcivia-Rodriguez J."/>
                <person name="Simonyan V."/>
                <person name="Kaur A."/>
                <person name="Dewar K."/>
                <person name="Matlashewski G."/>
            </authorList>
            <dbReference type="PubMed" id="30409989"/>
            <dbReference type="DOI" id=".1038/s41598-018-34812-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2